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<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ95</accession>
    <name>K9YZ95_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-carboxymethyl-2-hydroxymuconateDelta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.3.10" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217956.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0063"/>
    <dbReference type="EnsemblBacteria" id="AFZ52224">
        <property type="protein sequence ID" value="AFZ52224"/>
        <property type="gene ID" value="Cyan10605_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0063"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.65"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_3"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="28879" checksum="6929FC4361BF3226" modified="2013-03-06" version="1">MAQRYVRVKTITGQTYYGRLQLNRTVEVLDAPPWLNGKVTDLILQESDYRLLPPCAPSKIVAVGKNYSAHAAEMGSDIPKEPLIFLKPPSAIIAHEQAVIYPKQSQRVDFEGELALIIGDRTKNCSIEDAKDKIWGYTIANDVTARDLQKKDGQWSRAKGFDTFCPLGPWIVRELTSGARIQTYINEDENEPKQSALLSDMVFSPEELVAYISQIMTLLPGDVILTGTPEGIAPLQVGDSVTVEIESIGKLTNFIEASPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZC2</accession>
    <name>K9YZC2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Cyan10605_0129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218018.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0129"/>
    <dbReference type="EnsemblBacteria" id="AFZ52286">
        <property type="protein sequence ID" value="AFZ52286"/>
        <property type="gene ID" value="Cyan10605_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0129"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.131"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_3"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="304"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="554" mass="62302" checksum="7A246E4596763567" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZF1</accession>
    <name>K9YZF1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218021.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0132"/>
    <dbReference type="EnsemblBacteria" id="AFZ52289">
        <property type="protein sequence ID" value="AFZ52289"/>
        <property type="gene ID" value="Cyan10605_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0132"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.135"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_6_3"/>
    <dbReference type="OMA" id="YILGPRN"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="4"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="567" mass="62066" checksum="8F1467A6ACB4F0E0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZJ0</accession>
    <name>K9YZJ0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrin alpha subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218098.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0210"/>
    <dbReference type="EnsemblBacteria" id="AFZ52366">
        <property type="protein sequence ID" value="AFZ52366"/>
        <property type="gene ID" value="Cyan10605_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0210"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.220"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567085_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0401">Integrin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="481" mass="52037" checksum="A7F25E5EA74F00C2" modified="2013-03-06" version="1" precursor="true">MVVNLASGLSAITSSSNSQTHLVWAENSFLWYAKYDENSETWQEARAISKLENQDISNIQLLYEDNLIQEGNTEAKQPGFVVTWQQGSDNDSDFYYTAGKYDEQGELQWLANPQAITSDQVGDLEPTSIIYQGDVFLVGSKVDFLNQANQAIKEDTDLYFQRFTINDSLFYDGDVTPPLASYSPQLIQQGVITNLIPVNNTPQTVNTFNSNAGQGIGAQSDSSESESEAVVPEYSFAWGGGLEFSVDLLEVLKAKDNVPKGIVSKILTPFIKGVEIEVSLKGGQNSSSNTIIGSSGDNLNPYLSVEAKTTFEGKEVKKIATLVAAPEVEGEELVEESAQKEVSEATGNKGENENEGGEKEGSAFSVSLGIESEWSFDRETLLLNEIFDSITLTFEVDFPLVKVPLVEVSAFGDIGASFYVQAEPLPDGDYQPPLSAILEVLGGEILGAGVASLVGAVGNAMPKAQLRCPQLTVMNLPLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZN3</accession>
    <name>K9YZN3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218106.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0220"/>
    <dbReference type="EnsemblBacteria" id="AFZ52374">
        <property type="protein sequence ID" value="AFZ52374"/>
        <property type="gene ID" value="Cyan10605_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0220"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.229"/>
    <dbReference type="eggNOG" id="COG5626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137225_1_0_3"/>
    <dbReference type="OMA" id="WEWLIPH"/>
    <dbReference type="OrthoDB" id="1845842at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018741">
        <property type="entry name" value="DUF2288"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10052">
        <property type="entry name" value="DUF2288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11180" checksum="70BE9ACF6128425E" modified="2013-03-06" version="1">MSDFKAQLKEQLAEVDWKDLIPHAQRDALIIVHPQLDLIEVGCAIALDDTFLVQNWISEQLIKKPSSEELSNWNEEPEIKFKTLIVQPFVIASVIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZN7</accession>
    <name>K9YZN7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218111.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0225"/>
    <dbReference type="EnsemblBacteria" id="AFZ52379">
        <property type="protein sequence ID" value="AFZ52379"/>
        <property type="gene ID" value="Cyan10605_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0225"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.234"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_2_3"/>
    <dbReference type="OMA" id="TGSWHVG"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="18467" checksum="8C6F76178F5F4CEB" modified="2013-03-06" version="1">MEKTKLLFVCLGNICRSPSAENIMNHLIEKKGLAEKFECDSAGTSNYHIGSPPDRRMKEAARKRGIELRGKARQIEEFDLEYYDLILAMDKSNYHNILALDPKGKYKHKVKLMCDFAKNFTDQEVPDPYYGGESGFNYVIDLLLDACQGLLDYCQEKMVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZZ5</accession>
    <name>K9YZZ5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218220.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0342"/>
    <dbReference type="EnsemblBacteria" id="AFZ52489">
        <property type="protein sequence ID" value="AFZ52489"/>
        <property type="gene ID" value="Cyan10605_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0342"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.358"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088196_1_0_3"/>
    <dbReference type="OMA" id="EFRHRGE"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="26330" checksum="8F8CA57306CBFD20" modified="2013-03-06" version="1">MQTLDNLTLNNQVLSSQPLRIIAIGDSLVYGYGDKEGGGWVERLRRHWMNSPQDHVLYNLGIRGDRTSQVKKRLSLEFSYRGEIRNKYPDLIIMSVGVNDTPRLGHNQGRNQTSYEQFSVEINSLLDQAQELAPVMFVGMIPVDEDKMPFLDCFYFNLRDQYHYKEITKQACQLRNIPYLDTFDLWMSRGENWRKSQMSPDGLHPNVKGYETLFQEIQQWQPIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z035</accession>
    <name>K9Z035_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fe(3+)-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0385"/>
    <dbReference type="EnsemblBacteria" id="AFZ52529">
        <property type="protein sequence ID" value="AFZ52529"/>
        <property type="gene ID" value="Cyan10605_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0385"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.407"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_3"/>
    <dbReference type="OMA" id="RDRQFLG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="40"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="387" mass="43582" checksum="CC859583B2B3AFBB" modified="2013-03-06" version="1">MLLKMCNLKGKVIYLRLLKIILIKYQLSLARHIMVESVILQVKAVSKKFSAKQLPAVNQVSFDLKQGELLGLLGPSGCGKTTLLRMIAGFERLSEGSIFLANNIVAGDSMWVEPEKRKTGMVFQDYALFPHLSVADNIAFGLKTKKPRPNNQEIKQRVAEVLQLVGLSGLEKRYPHELSGGQQQRIALARALAPQPELILLDEPLSNLDVQVRERLRHEVRSILKSTNTAAIFVTHDQSEAMAIADKIGVMQDGKLLQLGTPEDIYTCPQCRFVAEFVTQANFVQATRQGDVWCTELGEWSLNLPVNYQEGELMFRQEDVILHPDEEGVTVIQEREFLGREYRYCLETKSGKRLHARTDVKTQLPVGTKVKLDVIPESAQIFPLIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0E0</accession>
    <name>K9Z0E0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="5" type="synonym">rpl4</name>
        <name evidence="7" type="ordered locus">Cyan10605_0524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218397.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0524"/>
    <dbReference type="EnsemblBacteria" id="AFZ52666">
        <property type="protein sequence ID" value="AFZ52666"/>
        <property type="gene ID" value="Cyan10605_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0524"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.554"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_3"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="23828" checksum="257B94CC0E6750AB" modified="2013-03-06" version="1">MVNCVVKNWQGEQVGETTLEMKVAKAENAEHIVHRALVRQLHNQRQGTVSSKTRAEVRGGGRKPWRQKGTGRARAGSIRSPLWRGGGVIFGPKPRDFDMKMNRKERKLAIRTAFMDRVEDLIVVENFDQIATPKTKEVVSALTRWGVEEDAKVLIVVNDSIPENLYLSARNLPTVKMIKHDCLNVYDILYADKIVATSEAITKIQEVYCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F7</accession>
    <name>K9Z0F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem II oxygen evolving complex protein PsbP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217924.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0031"/>
    <dbReference type="EnsemblBacteria" id="AFZ52192">
        <property type="protein sequence ID" value="AFZ52192"/>
        <property type="gene ID" value="Cyan10605_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0031"/>
    <dbReference type="eggNOG" id="ENOG502ZCA9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039569_2_0_3"/>
    <dbReference type="OMA" id="FLYPNGW"/>
    <dbReference type="OrthoDB" id="1496478at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002683">
        <property type="entry name" value="PsbP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="SSF55724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939010" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PsbP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20759" checksum="1756FD4C857E5D52" modified="2013-03-06" version="1" precursor="true">MLKSIATFIVIILTVTLSACVSPTGGLNPYVDGADGYKFLYPNGWMAVDVKEASEGVDVVFRDFIERSENLSVIISDVNKNMDLSDLGSPTDVGYRFMQIVNQDTNNQREAELISAEKREQNLEDYYLLEYKVKLGDNQYRHNLASVVTKNGKLYTFNISTTESRWENVENRFKTIVKSFTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N9</accession>
    <name>K9Z0N9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ordered locus">Cyan10605_0135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218024.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0135"/>
    <dbReference type="EnsemblBacteria" id="AFZ52292">
        <property type="protein sequence ID" value="AFZ52292"/>
        <property type="gene ID" value="Cyan10605_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0135"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.139"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134083_0_0_3"/>
    <dbReference type="OMA" id="FNTFQHV"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11493" checksum="CC9CBED8E0BBF59D" modified="2013-03-06" version="1">MTSTILASTIVAPNKSSQVTRKPYPNYKVIVLNDDFNTFDHVANCLIKYIPNMTPDYAWQLTNQVHFEGQALVWSGPLEQAELYHQQLRREGLTMAPLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T9</accession>
    <name>K9Z0T9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218505.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0635"/>
    <dbReference type="EnsemblBacteria" id="AFZ52774">
        <property type="protein sequence ID" value="AFZ52774"/>
        <property type="gene ID" value="Cyan10605_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0635"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_2_3_3"/>
    <dbReference type="OMA" id="HESSLIW"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018342">
        <property type="term" value="P:protein prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="30583" checksum="9CF0FE69B169F698" modified="2013-03-06" version="1">MVALHRQVLESRPDSFRGWFQQAEELKCQGFLIEALHSFDRALQYYQHDYYSWYYRGQILEEINSFLEAINSYKKACEIKSNNYWAWYNQGCIWQEKIENYQESIICFFNALKNKPEDYWSIYHLAKAYYAQKKYLLSLNYLQQALKIRPHDYWSYYWQGVCQQKLHQWQNARYSYQKALEIKPSDYWTLKQLATLAEIQCLYQDAIAFYSQLEEMGEDTEDIYYKLAQYHQILGNKSQALHYQQLITTKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U1</accession>
    <name>K9Z0U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0678"/>
    <dbReference type="EnsemblBacteria" id="AFZ52816">
        <property type="protein sequence ID" value="AFZ52816"/>
        <property type="gene ID" value="Cyan10605_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0678"/>
    <dbReference type="eggNOG" id="ENOG5032SGV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040989_0_0_3"/>
    <dbReference type="OMA" id="ENITSMM"/>
    <dbReference type="OrthoDB" id="1710742at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="29566" checksum="288D5B23197BE6A1" modified="2013-03-06" version="1" precursor="true">MKFSYLIKSRFSYLSFFLIFSSLLTPLSIISFLEKPVIAREDSLNFISRGEGVFTLEGRQQTKISSVSFNTTNNQNGQVSIILNNNQTINFDGRVSRQNANQLRIQVTNSGMATASGVLLLEHNDNDIVLLEGKGYLDSQGFSIIFRNRNANLPPVTKYSPLNLIQRGQGLLNIQGRQNQQLNFVSVQVNSQGKADISLGLQNGDRISFGGQESHRDSTNIKIRLTNSSSASADGFMNIRYGANNSIINLVGDGEIDGQPFLVNFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z170</accession>
    <name>K9Z170_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218682.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0819"/>
    <dbReference type="EnsemblBacteria" id="AFZ52951">
        <property type="protein sequence ID" value="AFZ52951"/>
        <property type="gene ID" value="Cyan10605_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0819"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.861"/>
    <dbReference type="eggNOG" id="ENOG5033DK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2863300_0_0_3"/>
    <dbReference type="OMA" id="FTEWNDE"/>
    <dbReference type="OrthoDB" id="2084056at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="7236" checksum="77F80AA78D8BFA30" modified="2013-03-06" version="1">MTTKLAEIKEMIFQLPPEEINQLIREVNETISTKDFMKLAETGFQEWNDPEEDIYNNDTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z197</accession>
    <name>K9Z197_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218072.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0184"/>
    <dbReference type="EnsemblBacteria" id="AFZ52340">
        <property type="protein sequence ID" value="AFZ52340"/>
        <property type="gene ID" value="Cyan10605_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0184"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.191"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388705_0_0_3"/>
    <dbReference type="OMA" id="FWLDAGS"/>
    <dbReference type="OrthoDB" id="207660at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="679" mass="78527" checksum="FC9501B56E709600" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A4</accession>
    <name>K9Z1A4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ordered locus">Cyan10605_0811</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0811"/>
    <dbReference type="EnsemblBacteria" id="AFZ52944">
        <property type="protein sequence ID" value="AFZ52944"/>
        <property type="gene ID" value="Cyan10605_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0811"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.854"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_3"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="36"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ52944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="34376" checksum="1B3ECE6F48EDE37E" modified="2013-03-06" version="1">MTITIKTDSETKVVTLTNTECNIYQSVSLSPFTSYRVGGKAQWYAEPKSWNDIQAIFTWLQKEQMPFTCLGGGSNLLISDRGIEGLVLNTRHLKQYLIDEDNLTITVGAGYPLPKLAWKAAKKGWQGLDWAVGIPGTVGGAVVMNAGAHKGCMADIFKSAIVAYSDGRIETLSKEDLEYSYRSSRLQKENALVLQATLNLESGQSKEEMMALTTSNFKMRKQTQPYDKPSCGSVFRNPKPQAAGWLIEQIGLKGHQIGGAQVAHRHANFILNAGNATARDIFNLIQYVQEKVEENWSILLHPEVKFLGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B0</accession>
    <name>K9Z1B0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9 10">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">miaB</name>
        <name evidence="14" type="ordered locus">Cyan10605_0859</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218722.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0859"/>
    <dbReference type="EnsemblBacteria" id="AFZ52991">
        <property type="protein sequence ID" value="AFZ52991"/>
        <property type="gene ID" value="Cyan10605_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0859"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.903"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_2_3"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="143"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="383"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="451" mass="51414" checksum="B6E246AF81D3FF77" modified="2013-03-06" version="1">MNQEKRLYNITTFGCQMNKADSERMAGILENMGFEFTEDPNQAKVLVYNTCTIRDNAEQKVYSYLGRQAKRKHQEPDLTLVVAGCVAQQEGEQLLRRVPELDLVMGPQHANRLDSLLEQVFAGNQIVATEPIHIYEDITKPRRESEVSAWVNIIYGCNERCSYCVVPNVRGVEQSRTPEAIKAEIEELAKQGYKEITLLGQNIDAYGRDLPGVTETGRHKHTLTDLLYYIHDIEGIERIRFATSHPRYFTERLIKACYELPKVCEHFHIPFQSGDNEILKAMKRGYTHERYRDIIAKIREYMPDAAISADAIVGFPGETEEQFQNTLKLVEDIGFDQLNTAAYSPRPNTPAAEWENQIDEQEKSDRLQRLNHLVAIKAGERSLRYQDRIEEVLVEDINPKDTTQVMGRTRGNRLTFFAGNLAELKGKVVSVKITEVRAFSLTGNALSLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E7</accession>
    <name>K9Z1E7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218762.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0901"/>
    <dbReference type="EnsemblBacteria" id="AFZ53031">
        <property type="protein sequence ID" value="AFZ53031"/>
        <property type="gene ID" value="Cyan10605_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0901"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.946"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_4_0_3"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="34160" checksum="738B9C5C72E8F74B" modified="2013-03-06" version="1">MGYIISTVNMKGGVGKTTLTVNLATCLAKGFGKKVLVLDLDAQISATLSLLPPHEFGKLRKKRKTLSYLIDLVVQPNPYAKLSIHDIITPSICDLPQLSLLPGDIELYDEYLVSEMLHQQAVKENKSNDFEWVWNNFERNLIHNILQPVINDYDFIIMDCAPGYNLLTRSAIAASDFYILPARPEPLSLVGIQLLERRIKRLKENHQEDNPLKLQLLGVVFILSESGLFGRYDKYYEQVKRRVKQDFTIDKIFASDIPMDVNVAKAVDLFIPVTLASPNCNGSKAFYKLTQEFLGKIEAINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E9</accession>
    <name>K9Z1E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218132.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0249"/>
    <dbReference type="EnsemblBacteria" id="AFZ52400">
        <property type="protein sequence ID" value="AFZ52400"/>
        <property type="gene ID" value="Cyan10605_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0249"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.258"/>
    <dbReference type="eggNOG" id="ENOG50330YA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175390_0_0_3"/>
    <dbReference type="OMA" id="IFIEWAN"/>
    <dbReference type="OrthoDB" id="1957989at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="9183" checksum="426D31B59E7F546B" modified="2013-03-06" version="1">MRKQIIQYTSSLDALIAIAKRLSIYENQHKMDSEDFFNKYNQGKFSDDAIFIEWANDYRHYIALHQELQERLNNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K6</accession>
    <name>K9Z1K6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">Cyan10605_0470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218343.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0470"/>
    <dbReference type="EnsemblBacteria" id="AFZ52612">
        <property type="protein sequence ID" value="AFZ52612"/>
        <property type="gene ID" value="Cyan10605_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0470"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.498"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_2_3"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="38799" checksum="C4A9DC92F6AA3D34" modified="2013-03-06" version="1" precursor="true">MKTNTLSVNRILNPTGWLLLILLTLILSTLSFVSLDKNQTLPLWIATLISGILGYIVVPILQKIKASQIIQEDGPQSHLKKAGTPTMGGIFFIPTGLIIALIMANFSPNVIALVLLTFAYSFIGWVDDWQILRKKTNLGLTPKQKLILQVGFAIIFCVWMFFTQPASITNVTLPFNIILPLSFLFWFVAVFVMVAESNATNLTDGVDGLAGGTGAIAFLGLGILIANSHPDLLIFCLAISGSCLGFVLHNRNKASVFMGDTGSLALGAGLAGVGILSENLWALFIISLLFFIESLSVIAQVTYYKATKDSEGKGKRLFKMAPIHHHLELSGWSETQIVGIFYIINTILVLMVVSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X0</accession>
    <name>K9Z1X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neutral amino acid ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218890.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1033"/>
    <dbReference type="EnsemblBacteria" id="AFZ53159">
        <property type="protein sequence ID" value="AFZ53159"/>
        <property type="gene ID" value="Cyan10605_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1033"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1095"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_0_3"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="286" mass="30648" checksum="86F348F9297E4CFA" modified="2013-03-06" version="1" precursor="true">MDSTIFQALFNGLAVGSIIALAAVGLTLTMGILRLSNFAHGDFLTVGAYLTWWINHFGLNIWLSMAIALLGTILIMLAGEQLLWKPLRKQKASSTSLIIVSIGLALFLRNGILFIWGGSNQNYDLPLVEALDFGGLKIAYYRLIVIIVTILAIVGLHLVLQKTKMGKGMRAVADNIDLARVSGINVEQIVLFTWVLTAILTATGGGLYGLITAVRPNMGWFLILPIFASVILGGIGNIYGAIAGGLIIGVAQELSVFIVGSEYKLGVALLIMIVILLVRPQGIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z230</accession>
    <name>K9Z230_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="5" type="synonym">rps13</name>
        <name evidence="8" type="ordered locus">Cyan10605_0503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218376.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0503"/>
    <dbReference type="EnsemblBacteria" id="AFZ52645">
        <property type="protein sequence ID" value="AFZ52645"/>
        <property type="gene ID" value="Cyan10605_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0503"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.533"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_3"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="14360" checksum="4F23A4F721216185" modified="2013-03-06" version="1">MARISGIDLPRDKRVEIGLTYLYGIGLTTSQKILAATGVNPDTRVRDLSDEDVTKLRNYIEENYQIEGDLRRLEAMNIKRLGDIGTYRGRRHRQGLPVRGQRTKTNARTRRGRRIAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z246</accession>
    <name>K9Z246_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="5" type="synonym">rpl16</name>
        <name evidence="9" type="ordered locus">Cyan10605_0518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218391.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0518"/>
    <dbReference type="EnsemblBacteria" id="AFZ52660">
        <property type="protein sequence ID" value="AFZ52660"/>
        <property type="gene ID" value="Cyan10605_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0518"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.548"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_3"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15851" checksum="1916711956D0AEB6" modified="2013-03-06" version="1">MLSPRRTKFRKQHRGRMKGNAYRGNSINFGDFALQAIEPCWITSRQIEAARRAITRYVRRGGKLWIRVFPDKPVTMRPAETRMGSGKGNPEFWVAVVKPGRIMFEIAGIPEATAREAMRLAAQKLPIKTKFVTRAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z264</accession>
    <name>K9Z264_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218548.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0679"/>
    <dbReference type="EnsemblBacteria" id="AFZ52817">
        <property type="protein sequence ID" value="AFZ52817"/>
        <property type="gene ID" value="Cyan10605_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0679"/>
    <dbReference type="eggNOG" id="ENOG502Z8IN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104980_1_0_3"/>
    <dbReference type="OMA" id="HFRSRMN"/>
    <dbReference type="OrthoDB" id="1691688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021399">
        <property type="entry name" value="DUF3038"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11237">
        <property type="entry name" value="DUF3038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="24279" checksum="9976E9B880CE88D4" modified="2013-03-06" version="1">MTDSNTELINQEKSDKSEITILKTLPDLILPPPSGMMRVQQQLDLLLLALEALQLGGSEYMLAIGKELELNPIIKNRLSLWRLRCSNPWRKCYTRESLSLAQVKALTLITVKCAKKFVLPIRQLLVAAQQMEDKGMPLENNFRLSEYFSRFRSHFLRRMNHRRAKVSIYASSPDELNKLALSLLEELLFYTGIRGEERLWVKIFDGEVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z293</accession>
    <name>K9Z293_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218583.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52852">
        <property type="protein sequence ID" value="AFZ52852"/>
        <property type="gene ID" value="Cyan10605_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0716"/>
    <dbReference type="eggNOG" id="ENOG5033GBZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2733282_0_0_3"/>
    <dbReference type="OMA" id="NHLWQKI"/>
    <dbReference type="OrthoDB" id="1988529at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="71" mass="8368" checksum="A14EFC2B91CE66C5" modified="2013-03-06" version="1">MSIVDLIKAEIDNIPENKLAELYQYIKKLVKPEKTLNHLWQKIDELGEDEDQLSMEEIVSLVKEVRENKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D0</accession>
    <name>K9Z2D0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219090.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1243"/>
    <dbReference type="EnsemblBacteria" id="AFZ53361">
        <property type="protein sequence ID" value="AFZ53361"/>
        <property type="gene ID" value="Cyan10605_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1243"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1310"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_9_3"/>
    <dbReference type="OMA" id="ICINAGG"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="35077" checksum="DB262D901AE20A10" modified="2013-03-06" version="1">MEKIKIRGINHHYQFIKTQQDLTKPVLVFIHGWLLSHHYWLPLIEQIKHEYSCLTYDLKGFGLSQWDENTSVNNSEFDLSGYAQDLKILLQELAIEKAWLVGHSLGGSVALWTADICREKVTGVFCVNAGGGIYLQEEFERFRKAGENLVKFRPSWFVNVPFFDFIFSRMMVKRPLGRQWGKQRLKDFLSANEQAAIASLLESTTEEQVHYLPQIVSRLSQPVYFIAGKQDKVMEVQYVKHLASFHQLFQQNQKNVYEIDNCGHFAMLEHTQQVKDYILEIMIEHSSQNEILAEFTPSKGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L3</accession>
    <name>K9Z2L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218349.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0476"/>
    <dbReference type="EnsemblBacteria" id="AFZ52618">
        <property type="protein sequence ID" value="AFZ52618"/>
        <property type="gene ID" value="Cyan10605_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0476"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.504"/>
    <dbReference type="eggNOG" id="COG1035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038110_0_0_3"/>
    <dbReference type="OMA" id="WTGIVST"/>
    <dbReference type="OrthoDB" id="708486at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FrhB_FdhB_N" evidence="1">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FrhB_FdhB_C" evidence="2">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="397" mass="44679" checksum="09B38C225C102826" modified="2013-03-06" version="1">MTVINSHRKAKALKQGSRRPAKDLCSECGLCDTYYIHYVKEACAFINQQITELETIAHGRSRDLNNENDLYFGVHQEMMSAKKIEPIEGAQWTGIVSTIACEMLTQGLVEGVVCVQNSDEDRFQPKPIIATTTEEILGAKVNKPTLSPNLSVLEQIEQSGMKRLLVIGVGCQIQALRAVEDKLGLEKLYVLGTPCVDNVTRAGLQKFLETTSKSPDTVVAYEFMQDFRVHFKHEDGSVEKVPFFGLKTNQLKDVFAPSCMTCFDYVNSLADLVVGYMGAPFGWQWIVVRNDIGREMLDLVKNQLHTQPVISRGDRTQAVQNSIPAYDQGVTLPMWAAKLMGVVIEKVGPKGLEYARFSIDSHFTRNYLYVKRNYPEKLKDHVPEYAEKIVSQYKLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q2</accession>
    <name>K9Z2Q2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ordered locus">Cyan10605_1314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219158.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1314"/>
    <dbReference type="EnsemblBacteria" id="AFZ53429">
        <property type="protein sequence ID" value="AFZ53429"/>
        <property type="gene ID" value="Cyan10605_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1314"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1387"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_3"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="144"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="430" mass="46242" checksum="B0EB8EBF87DB8545" modified="2013-03-06" version="1">MLEQESMLIEDITAREILDSRGKPTVEAEVRLESGAVGIAQVPSGASTGTFEAHELRDGDSRRYEGKGVLKAVDNIIEKITPVLLSLDAFDQVAVDTAMIDRDGSTNKKNLGANAILAVSLANAKAAAAELGIPLYRYLGGPLANVLPVPMMNVLNGGSHANNNVDFQEFMIMPVGAESFSEALRWGAEIFGCLSKVLKDKNLLTGVGDEGGYAPNLGSNQEALDLLVAAIESAGYKPGTDVALAMDVAASEFYKDGQYVYDGSAHSPSEFIAYLEELVSKYPIISIEDGLQEEDWDNWKILTEKLGSKIQLVGDDLFVTNPTRLQKGIDLGVANSILIKLNQIGTLTETLRTIDLATRKGYTSVISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEHELGDRAIYAPKVGLGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W1</accession>
    <name>K9Z2W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218419.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0547"/>
    <dbReference type="EnsemblBacteria" id="AFZ52688">
        <property type="protein sequence ID" value="AFZ52688"/>
        <property type="gene ID" value="Cyan10605_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0547"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.578"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_10_2_3"/>
    <dbReference type="OMA" id="RPENWRL"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="10986" checksum="56AF9A57EADE7BFF" modified="2013-03-06" version="1">MPTIKFIKENKEVVAADGANLREKALQNNIDIYKWRGKLINCGGYGQCATCVVEIVEGMENLSPKTDFETRKLKKKPENYRLACQTLVNGPISVNTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z324</accession>
    <name>K9Z324_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218853.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0993"/>
    <dbReference type="EnsemblBacteria" id="AFZ53122">
        <property type="protein sequence ID" value="AFZ53122"/>
        <property type="gene ID" value="Cyan10605_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0993"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1050"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_3_3"/>
    <dbReference type="OMA" id="RRDQLPN"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="8">
        <location>
            <begin position="263"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="8">
        <location>
            <begin position="335"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="42933" checksum="375E94317F8F45BB" modified="2013-03-06" version="1">MSIVKLSGLQALISEISQTHNLPRTSVEEALREALFKGYERFRRSKLGEKAHSMLPPEYFDNFRVELDLEEEGFRVLALKMVTDSVEDPDHQIALAEVQEFNEEVQLGNEVLVDVTPEQKDFGRMAAMQTKQVLQQKLKEQQRAIIQAEFTELEGTVLSAKVLRFEGQSVIMTVQSAYGRPEVEAELPRGEQLSSDNYRANATFKVYLKRVKEGVHRGAQLIVSRADAGLVVYLFANEVPEIEEGIIRIVAISREANPSKPDITARTKIAVDTLERDVDPVGACIGARGSRIQAVVNELKGEKIDVIRWSPDPATYIANALSPAKIDIVELIDPDEKQSLVVVPDNHFSLAIGKDGQNVRLAARLTGWKIDIKKKSDYLNEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z389</accession>
    <name>K9Z389_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218564.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0697"/>
    <dbReference type="EnsemblBacteria" id="AFZ52833">
        <property type="protein sequence ID" value="AFZ52833"/>
        <property type="gene ID" value="Cyan10605_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0697"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_38_3"/>
    <dbReference type="OMA" id="ETIVATW"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="253"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="511"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="633" mass="74002" checksum="991E1CA906B5886D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z397</accession>
    <name>K9Z397_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ordered locus">Cyan10605_1520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219356.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1520"/>
    <dbReference type="EnsemblBacteria" id="AFZ53629">
        <property type="protein sequence ID" value="AFZ53629"/>
        <property type="gene ID" value="Cyan10605_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1520"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1615"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_3"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="268" mass="28402" checksum="49744249C477264A" modified="2013-03-06" version="1">MSFKLGVIGGGVMAEAIISRLLAQNIYIASEIIISDPALSRRQWWEEKYQVETTTDNQRVLDDSQVLLLAIKPQIFERVVEGLTINPHRHIPLILSILAGTSLSQLERAFASLPIIRVMPNTPALVGQGMSAIAPNGKVSESQLSLALSLFEAIGSVIQVPEYQMDAVTGLSGSGPAFVALMIEALADGGVASGLPRAIALELAVQTVLGTAELVKQKNLHPALLKDQVTSPGGTTIAGVAALEEKGFRSAVISAVKSAYLRSQELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F1</accession>
    <name>K9Z3F1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="19" type="ordered locus">Cyan10605_1608</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219443.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1608"/>
    <dbReference type="EnsemblBacteria" id="AFZ53716">
        <property type="protein sequence ID" value="AFZ53716"/>
        <property type="gene ID" value="Cyan10605_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1608"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1708"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_3"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
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</entry>
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            <dbReference type="PubMed" id="23277585"/>
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
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                <person name="Goodwin L."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">PCC 10605</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0841"/>
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        <property type="protein sequence ID" value="AFZ52973"/>
        <property type="gene ID" value="Cyan10605_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0841"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="GYYWSKP"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="EAL_dom"/>
    </dbReference>
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        <property type="entry name" value="EAL_sf"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GGDEF"/>
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    </dbReference>
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        <property type="entry name" value="Response_reg"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="184"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="326"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="589" mass="68251" checksum="1444BAB40CA6E6AA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T7</accession>
    <name>K9Z3T7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219593.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1764"/>
    <dbReference type="EnsemblBacteria" id="AFZ53866">
        <property type="protein sequence ID" value="AFZ53866"/>
        <property type="gene ID" value="Cyan10605_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1764"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1872"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075279_2_0_3"/>
    <dbReference type="OMA" id="WEKQNRC"/>
    <dbReference type="OrthoDB" id="1187677at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="28221" checksum="8AC45479ADD4F015" modified="2013-03-06" version="1">MVTQIQIPTGNEVEFIPKPDVSHLITEDDTPVDNFGSAKQQRFLTSILYHARKEVIFLADANVGIYYSIGKPPIVPDFFLSLNVTTPENFWEKNHRCYLIWEFGKPPEFALEIVSNKVGGELEEKLKIYQDMRVSYYGVYDPQKYLSDQVLKIFKLTGIHYQETSDTWLEGVNLGLTVWEGEFENVNGVWLRWCDQSGNLLLTGDESVQKAILEQKEQEKRAEKAEKELQELKEKLRQQGINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V5</accession>
    <name>K9Z3V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218794.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0933"/>
    <dbReference type="EnsemblBacteria" id="AFZ53063">
        <property type="protein sequence ID" value="AFZ53063"/>
        <property type="gene ID" value="Cyan10605_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0933"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.981"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108009_0_0_3"/>
    <dbReference type="OMA" id="NQAFHDR"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="21381" checksum="1C43003CFD0B6624" modified="2013-03-06" version="1">MYSEENQFRRVPKAPFERRAYAFLIDFIIVWIFSSLVTNIFLELVIFVLLWFIFRVIIVQINKGQSLGRWAMDLKIADIRRKRQPSMVSMSKREGVIALIAFTAMIGLKINFKDSLLMVLLLTPIIVDGLTIFSDDEYNQAFHDRLCDTIIIQTRRGFSLDLRLKKLFKEAKETWQKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z406</accession>
    <name>K9Z406_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate transport 45kD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219206.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1363"/>
    <dbReference type="EnsemblBacteria" id="AFZ53477">
        <property type="protein sequence ID" value="AFZ53477"/>
        <property type="gene ID" value="Cyan10605_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1363"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1438"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037398_3_0_3"/>
    <dbReference type="OMA" id="GPKKDMA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="440" mass="48446" checksum="CF3BC835C498885D" modified="2013-03-06" version="1" precursor="true">MSKLSRRKFIFTTGATALTTAILHGCAQGGGNQTTTENTTPENAPVISPEDAPEVTGAKLGFIALTDAAPLIIAKEKGFYAKYGMPDVEVIKQASWGTTRDNLVLGSASGGIDGAHILTPMPYLISMGTVTDGKPTPMYILARLNVNGQGIMLGNNYKDLKVGLDTSPLKEAFTKVTDPKVAMTFPGGTHDCWIRYWLAAGGLEPGKDVSTIVVPPAQMVANVKVNAMESFCVGEPWPLQTVNQGVGYQAITTGQLWKDHPEKAFGMRKDWVDANPKAAKALLMAVLEAQQWCDKPENKEEMCQIVSKREWFKVPFEDIIDRSKGIYNYGNGDPTFEDTELMQKYWTDNASYPYKSHDLWFLTENIRWGYIPADTDTKKIVDEVNREDLWREAATALGVPESEIPTSPSRGVETFFDGITFDPENPQAYLDSLKIKTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z411</accession>
    <name>K9Z411_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two component response regulator sensor histidine kinase/response regulator subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219211.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1368"/>
    <dbReference type="EnsemblBacteria" id="AFZ53482">
        <property type="protein sequence ID" value="AFZ53482"/>
        <property type="gene ID" value="Cyan10605_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1368"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2408319_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="92" mass="10590" checksum="B00C682003241CBC" modified="2013-03-06" version="1">MAILFGVLTICKDISEQKAIEFALRTSEARWQFALDGASHGVWDVNLVTNETYYSPKFMEMLGYELGEWGNSFDDWHKYRYNRSHPHGAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z458</accession>
    <name>K9Z458_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219256.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1415"/>
    <dbReference type="EnsemblBacteria" id="AFZ53527">
        <property type="protein sequence ID" value="AFZ53527"/>
        <property type="gene ID" value="Cyan10605_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1415"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699832_0_0_3"/>
    <dbReference type="OMA" id="HGWHEGR"/>
    <dbReference type="OrthoDB" id="1496330at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="44686" checksum="4D9E3C65F38B5E14" modified="2013-03-06" version="1">MIERIGQWLKLIPTTIQPYDPEKDDVKGKNGDSTATHPVVKDGDLEFLFYQLLEGVANGWQESRIEQFFEKLEPRISLETWLDWLQRYRNQLIKSSHGHSQLAVRMIRLGELTATLPFMRGVGDLAYEIGKELLNQTTSNNFVNSFNSHHQENIDKNIDKIEDKTPINEVTESLTAKINSPTSLGELLSLLQKDENFASEIAHQLNLNTVDPSVIIAKIVEQTESDSLPIFSGSISEELVEYLFNLGLEKASAGDFEEALISWNQAVTLNPDFAPAWHNKGSALAYLNRLPEAVQSFEQAIALNVNDLDSWYDRGSALFSMGQWQEAIISWERVIGIQPNHYQAWYHRGLALEKLKKLGDALNSYGKCLSINPLFTPAQKRQEKLNLLLSSNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z460</accession>
    <name>K9Z460_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1247"/>
    <dbReference type="EnsemblBacteria" id="AFZ53365">
        <property type="protein sequence ID" value="AFZ53365"/>
        <property type="gene ID" value="Cyan10605_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1247"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1315"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456943_0_0_3"/>
    <dbReference type="OMA" id="TQWTVEL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="545"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="662" mass="72566" checksum="DDB28AF6CE42798C" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z479</accession>
    <name>K9Z479_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1047"/>
    <dbReference type="EnsemblBacteria" id="AFZ53173">
        <property type="protein sequence ID" value="AFZ53173"/>
        <property type="gene ID" value="Cyan10605_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1047"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1108"/>
    <dbReference type="eggNOG" id="COG3751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477954_0_0_3"/>
    <dbReference type="OMA" id="KIGFECY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="451"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="570" mass="65777" checksum="AD95E50636E43B79" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A8</accession>
    <name>K9Z4A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem II S4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218924.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1069"/>
    <dbReference type="EnsemblBacteria" id="AFZ53193">
        <property type="protein sequence ID" value="AFZ53193"/>
        <property type="gene ID" value="Cyan10605_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1069"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1131"/>
    <dbReference type="eggNOG" id="COG2302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075687_0_0_3"/>
    <dbReference type="OMA" id="MSRSKMV"/>
    <dbReference type="OrthoDB" id="1477108at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017506">
        <property type="entry name" value="PSII_S4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03069">
        <property type="entry name" value="PS_II_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="28804" checksum="208D3D131C9922E6" modified="2013-03-06" version="1">MLPREELLKRVENKEDIARVIDKAEKAVKTWELVVTDFLSPPVLAEVNEIFASLTEVKIVCWGGYPQAERQRVGIHREEVYAGVAEIPLMALDVAGNFLFDTATHRDFLGAILGTGIVRDKIGDIIVLGERGAQVIVTPEIGEFLETSLTQVRSVPVKTGKIDLSDLKIRPPKKKEMTTVEASLRLDAIASFGFGISRSKMADAINNGDVRVNWKEITQPSYNVKDGDLVSFRGKGRLEIGAIALTKKERYRINLTRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F7</accession>
    <name>K9Z4F7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219749.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1928"/>
    <dbReference type="EnsemblBacteria" id="AFZ54024">
        <property type="protein sequence ID" value="AFZ54024"/>
        <property type="gene ID" value="Cyan10605_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1928"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2049"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066599_0_0_3"/>
    <dbReference type="OMA" id="QTCCLKT"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="88"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="353" mass="38232" checksum="ED1F355F3B7ED1BE" modified="2013-03-06" version="1" precursor="true">MPSDRPLQRRQVLRLATLATGASLFPSACRAINSTVADNKVTAQSASSSPLNPPQISKVVLVYNEDRSAGTRQALDLLQPTGLKGKTVFLKPNYNTGDPAPAATDSQLLETLIQEFQGAQVGEMTIGDRSGMADTRQAMEQKGVFQLGEKYGVKTLVFDEMEAEKWQYISAEGTHWQKGFAFARPILDSEAIVNTCCLKTHQYGGHFTLSLKNSVGMVAKYVPGDSFNYMGDLHSSAHQRLMIAEINQAYKPSLVLLDGVEAFVNGGPASGKKVRSNVILAGVDRVAIDVVAIALLRLLGTTNQVSNGSIWELEQIQRAVELGLGIGQSEQIEFITPDAKSRGIVDQIRPLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K3</accession>
    <name>K9Z4K3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219794.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1974"/>
    <dbReference type="EnsemblBacteria" id="AFZ54069">
        <property type="protein sequence ID" value="AFZ54069"/>
        <property type="gene ID" value="Cyan10605_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1974"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2095"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="317" mass="35032" checksum="125E9DAA0BE67F2F" modified="2013-03-06" version="1">MITVEKLSKNYGSTQAIKDISFSVEKGSILGLLGANGAGKTTTMRILSGYIPATTGKAIIDGFEVHENPLAVRERIGYLPENPPLYPEMTVTEYLDFVGKIKNIPRCDRTSSLKKAIELCQIEDRANSIIGKLSKGYRQRVGIAQAIIHDPPVIILDEPTVGLDPRQIIEVRNLIKSLAKEKTIILSTHILPEVTMTCDTVTIINQGMVIATGKTEELLQQLNNKGYHLEVEGEVNGLTSKLKKIEAIDKIIIEPITGIDNRFIIKLSLKNDSEVGKEIASMLVHEGVGIYEMRRLKASLEEVFLQLTTQENISVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K9</accession>
    <name>K9Z4K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219052.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53323">
        <property type="protein sequence ID" value="AFZ53323"/>
        <property type="gene ID" value="Cyan10605_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1204"/>
    <dbReference type="HOGENOM" id="CLU_2421990_0_0_3"/>
    <dbReference type="OrthoDB" id="1657577at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10974" checksum="AB879AB0FE7D1C3E" modified="2013-03-06" version="1">MKKAGWDCLRHYEIIAQGCAPYFLDIRELPYLTMHRFPRYEVLKLMQIADNYLETENLDLDNYLTSFESLLNYTKKYLTTKSLAQYFVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R6</accession>
    <name>K9Z4R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219434.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1599"/>
    <dbReference type="EnsemblBacteria" id="AFZ53707">
        <property type="protein sequence ID" value="AFZ53707"/>
        <property type="gene ID" value="Cyan10605_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1599"/>
    <dbReference type="eggNOG" id="ENOG5032QUC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105713_0_0_3"/>
    <dbReference type="OMA" id="GMLEDLC"/>
    <dbReference type="OrthoDB" id="1798945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="204" mass="23336" checksum="96BBE8488DDA77E6" modified="2013-03-06" version="1">MSQEIKQINKPKLLIGEGKDEIRFFQSFLKYLNICDMMVESYNGKDNLYSYLKTLVLRPNFSQLVSIGITRDADNKPIEDLFKSICSALKRANLSNPNNLSKSSKGTPKINIFILPDNQNSGMLETLCLKSLKNDISMNCVDKYFDCIRQKSDIFPKNIDKAKIHAWLASREIPDKRLAEASEVGYFDFNNSAFDNLKEFIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S5</accession>
    <name>K9Z4S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219874.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2060"/>
    <dbReference type="EnsemblBacteria" id="AFZ54149">
        <property type="protein sequence ID" value="AFZ54149"/>
        <property type="gene ID" value="Cyan10605_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2060"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2189"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023736_3_1_3"/>
    <dbReference type="OMA" id="FELHYHL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="402" mass="45659" checksum="1A687BBD8B98BBA9" modified="2013-03-06" version="1">MVHNSNISLAMIVKNEAHNLPKCLDSVKDIVGEMIIVDTGSTDNTKEIGINYGAKVYDYQWNDDFAQARNFGLQYVSGDWVLVLDADEVFNPKIISQITPLMEKDDCLVINLIRHEIGTVSSPYSSLSRLFRRHPQISFSRPYHALIDDSVIALQEKEKQWKIFDSNEVAIAHYGYQPEVIAQQEKAQKARKAMESYLAQNPHDAYVCSKLGALYVSLGEIKKGLKLLKTGLKSSLATSTTLFELHYHLANAYVKEGQISLAVKHYQKAIASPILGKLKLGAYHNFGSLCYQRGQYQQALNLYRQCIIIEPHYAFAYYNLGLTHRAMGNISLAMETYRQSIKLNPEYPWAYQNLGVLLLQQGYMEESAEVFQKAYNLHKQQNRPVAENLKEELKLVGLNLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W3</accession>
    <name>K9Z4W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219182.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1339"/>
    <dbReference type="EnsemblBacteria" id="AFZ53453">
        <property type="protein sequence ID" value="AFZ53453"/>
        <property type="gene ID" value="Cyan10605_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1339"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1413"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_7_3"/>
    <dbReference type="OMA" id="VHGMGLA"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="742" mass="82441" checksum="9DF6B849646BB144" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X3</accession>
    <name>K9Z4X3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219941.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2128"/>
    <dbReference type="EnsemblBacteria" id="AFZ54216">
        <property type="protein sequence ID" value="AFZ54216"/>
        <property type="gene ID" value="Cyan10605_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2128"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2264"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_2_2_3"/>
    <dbReference type="OMA" id="YGDQLWA"/>
    <dbReference type="OrthoDB" id="880710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4 5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27784" checksum="5ABD167680B5F219" modified="2013-03-06" version="1">MKPYQKIIIQECGEPLVQIPEQDFYLETPSAYARLGADYQGKSPYFLRAGVLDKLLIAKEELKKINPHWKIRIFDAYRPVSIQKFMVEYTFNSICKEREINVDILGEEEKEKIYQEVFKIWAIPSDNPLTPPPHSTGGAIDLTIMDENKQSIPMGGEIDELSPVSLPDYYLDARDEPEKTYHQHRQILLQIMTKAGFHRHREEWWHFSYGDQMWAWLENEANPQSHYIAKYGKYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X7</accession>
    <name>K9Z4X7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_1526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219362.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z4X7"/>
    <dbReference type="STRING" id="755178.Cyan10605_1526"/>
    <dbReference type="EnsemblBacteria" id="AFZ53635">
        <property type="protein sequence ID" value="AFZ53635"/>
        <property type="gene ID" value="Cyan10605_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1526"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1621"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_3"/>
    <dbReference type="OMA" id="MVRVHHL"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="354"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="470" mass="51695" checksum="C5AF85008273A95D" modified="2013-03-06" version="1">MKHHTKIVATIGPASNSPEIIKQMVMAGMSVARLNFSHGTYEDHAQIVSLLRRVSEELDTPITLLQDLQGPKIRVGQLPSGQVEIKQGDKLTLIPENWEQTGENIITIDYPYLAEEAEIGTQILLDDGLLEFKIVAIEKPMVICEVIEGGILKSRKGVNLPSLNLRLPSMTEKDKKDLKFGLSQGVDWVSLSFVRRAQDIITLKQFLAQNNAQDTPVIAKIEKPQAVDNLEEIINECDGIMVARGDLGVEMSPEKVPLLQKQIISLCNRQVKPVITATQMLDSMIRSPRPTRAEASDVANAIIDGTDAIMLSGESAVGSYPVKAVEMMAKIALSVEPNLNFTNHPPSLSDETHALSEALNAIDKTMSLKFIVAYTKSGYSAIIAAGERSKTPVLALTVEDKVYHRLNLVWGVKPILIDQEPLNFEDLLNQVETVIHRRNLAKKGDRILIMAGIPTGISKGTNFLKIHVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y2</accession>
    <name>K9Z4Y2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ordered locus">Cyan10605_1694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219524.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1694"/>
    <dbReference type="EnsemblBacteria" id="AFZ53797">
        <property type="protein sequence ID" value="AFZ53797"/>
        <property type="gene ID" value="Cyan10605_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1694"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1798"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_3"/>
    <dbReference type="OMA" id="WIPSFGY"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="34903" checksum="03105D7B3B67D956" modified="2013-03-06" version="1">MAGSIVNADVWISEYITPYDIYAHGITSILAHKKTPYQEMYIVESGAYGKALVLDGKWQSCTGDEFLYHEALVHPAMVNHPNPENVLILGGGEGATTREVFRWHSVKQAKMVDIDGDVVEACKEYLPEMHQGSFDDPRLDLVIGDAFEVIDNSEAKWDVIISDLSDPIEEGPSFQLFTQEYFARLKKILRENGIVVIQAGPIAPANLHIHGRLVNTLKTVFSNVHSYFAPTCTYGSSWGFAIASEATFETRPNPEKVDLLLEQKTTADFRSFDGISLLGMLQTPGYVRQCIEKETEVYTMTKPPKFFGKGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z542</accession>
    <name>K9Z542_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(P)ppGpp synthetase I, SpoT/RelA</fullName>
            <ecNumber evidence="6">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219589.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1760"/>
    <dbReference type="EnsemblBacteria" id="AFZ53862">
        <property type="protein sequence ID" value="AFZ53862"/>
        <property type="gene ID" value="Cyan10605_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1760"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1867"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_3"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="407"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="675"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="751" mass="86156" checksum="1BB54A9F1989C284" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z569</accession>
    <name>K9Z569_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphoribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the phosphoribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.19" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219287.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1447"/>
    <dbReference type="EnsemblBacteria" id="AFZ53558">
        <property type="protein sequence ID" value="AFZ53558"/>
        <property type="gene ID" value="Cyan10605_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1447"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1535"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033590_1_0_3"/>
    <dbReference type="OMA" id="GLKMRAT"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00478">
        <property type="entry name" value="PHRIBLKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00567">
        <property type="entry name" value="PHOSPHORIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="5">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="335" mass="38195" checksum="C83CE9445CB5BFF6" modified="2013-03-06" version="1">MTQDRVVIIGVAGDSGCGKSTFLRRLEDLFGKEFMTVICLDDYHSLDRKGRKEAGVTALDPKANNFDLMAEQIAALKNGQAIDKPIYNHETGEIDPPERIEPNKVIVIEGLHPFYDERVRNLVDFGVYLDISEEVKIQWKIQRDMAERGHTYEDVLASINARKPDFTAYIEPQKQYADIVIQVLPTQLIEDKEGKILRVRLIEKEGIEHFEPTYLFDEGSTIDWRPCGRKLTCAYPGLKMYYGPDNYMGNEVSILEIDGQFDNLEEIIYVESHLSRTGTKYYGEMTELLLKHKDYPGSNNGTGLFQVLVGLKMRETYEKLTGSATFSTEEEVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z580</accession>
    <name>K9Z580_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Cyan10605_2213</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220024.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2213"/>
    <dbReference type="EnsemblBacteria" id="AFZ54299">
        <property type="protein sequence ID" value="AFZ54299"/>
        <property type="gene ID" value="Cyan10605_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2213"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2352"/>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094161_0_1_3"/>
    <dbReference type="OMA" id="DCLTVWL"/>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ54299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="21833" checksum="AA8546EB0890994E" modified="2013-03-06" version="1">MSITLVTGAANSGKSEWAEYLASQCQKPVIYIATGLKNDHDIEWQKKIEQHQIRRPENWQTLEIPYNLVDAIALNFSDNCILVDSLGTWVANYLDKNNDDWQKEINHLLETCREYKGEIIFVGEETGWGVVPAYELGRLFRSRLGNLIRLVGGIANSVYLMVGGYAVDVAKLGINLTSVQDKIIGSQQDKKFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A6</accession>
    <name>K9Z5A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219462.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1628"/>
    <dbReference type="EnsemblBacteria" id="AFZ53735">
        <property type="protein sequence ID" value="AFZ53735"/>
        <property type="gene ID" value="Cyan10605_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1628"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1728"/>
    <dbReference type="eggNOG" id="ENOG50313FK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891796_0_0_3"/>
    <dbReference type="OMA" id="ALPFWGI"/>
    <dbReference type="OrthoDB" id="1788123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="15292" checksum="553D2649D2471040" modified="2013-03-06" version="1">MVLTLENLIAMAEDQLTEYSTDARKIEKLRRKIGIALNFQEQQKLKQELLNKMPQGFWAKKIESQRQSFALPFWGIGGLGLLLGISSQQYLDFLAPAIAIPIAIKIQQYGWKLQAQKLLLKTFEDIEKRIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G1</accession>
    <name>K9Z5G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde decarbonylase</fullName>
            <shortName evidence="1">AD</shortName>
            <ecNumber evidence="1">4.1.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fatty aldehyde decarbonylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarbonylation of fatty aldehydes to alkanes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:21440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83563"/>
            <dbReference type="EC" id="4.1.99.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="1">Binds 2 metal cations per subunit. The catalytic dinuclear metal-binding site could be either a di-iron or a manganese-iron cofactor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde decarbonylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.5" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219522.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1692"/>
    <dbReference type="EnsemblBacteria" id="AFZ53795">
        <property type="protein sequence ID" value="AFZ53795"/>
        <property type="gene ID" value="Cyan10605_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1692"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1795"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106729_0_0_3"/>
    <dbReference type="OMA" id="GEQEAHD"/>
    <dbReference type="OrthoDB" id="924133at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990465">
        <property type="term" value="F:aldehyde oxygenase (deformylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009924">
        <property type="term" value="F:octadecanal decarbonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00931">
        <property type="entry name" value="Aldeh_decarbonylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022612">
        <property type="entry name" value="Ald_deCOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11266">
        <property type="entry name" value="Ald_deCOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04059">
        <property type="entry name" value="Ald_deCOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="26316" checksum="2CBE3A6CDA6E78B3" modified="2013-03-06" version="1">MQQLVEPTIDFNSDVYKDAYSRINAIVIEGEQEAHDNYMDMIPMLPNHEKELASLAKMEFRHKKGFQSCGRNLSVTPDMDFAQKYFAELHSNFQKAKEEGKIVTCLLIQALIIEAFAIAAYNIYIPVADPFARKITEGVVKDEYLHLNFGEEWLKANFEASKAELEEANRQNLPIIWRMLNEVEKDAKTLGMPKEELIEDFMISYGEALANIGFSTREIMKMSSYGLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G6</accession>
    <name>K9Z5G6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219707.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1882"/>
    <dbReference type="EnsemblBacteria" id="AFZ53982">
        <property type="protein sequence ID" value="AFZ53982"/>
        <property type="gene ID" value="Cyan10605_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1882"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_3_1_3"/>
    <dbReference type="OMA" id="ETVNIHQ"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="8721" checksum="36073B8A4DEEC31A" modified="2013-03-06" version="1">MKITNIQQAKSQLSKLIEAVLQGEDVIISKAGKPLVKIIPYTANSEPRKPGYWKGKVTMAEDFDTLPESIINSFTGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L3</accession>
    <name>K9Z5L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54032">
        <property type="protein sequence ID" value="AFZ54032"/>
        <property type="gene ID" value="Cyan10605_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1936"/>
    <dbReference type="HOGENOM" id="CLU_3198783_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="45" mass="5128" checksum="CCAAF562FD94F8C2" modified="2013-03-06" version="1">MGIREIVDNSSDLEFRIVRLMLVPIEIELTFIKEIATIPLVSAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q1</accession>
    <name>K9Z5Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA m(5)U-1939 methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1798"/>
    <dbReference type="EnsemblBacteria" id="AFZ53900">
        <property type="protein sequence ID" value="AFZ53900"/>
        <property type="gene ID" value="Cyan10605_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1798"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1907"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_3"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="450" mass="51011" checksum="09FF4ECAC1F04875" modified="2013-03-06" version="1">MIKQGDLVEVEIDDVSSEGSGVARVDQQVVFIPNTVTGDRISSRIVRVKKKYAQGQLEEFRKNSAYRIRPRCIVADKCGGCQWQHINYSYQLQLKQNQVKETLTRIGGFADLQVEPIISGEDLSYRNKVNYPLGVSHTGQIKAGYYRQGSHQIVNINQCPIQDQRLNPLLAEIKQDLQQLQIPIYDEKNHKGALRHLCFRIGKNTGEILLTLVSAELSDDAMDKQAEKWMKRYPNLVGVTLNYNPQKTNVIFGQKTELLAGRPYLIEQFARLNYHLRAETFFQVNTTVAEDLLTAILNKLSLTGEETVLDLYCGVGTFTLPFAQKVKKAIGVESYSLSIEQAQRNAEINNIDNVEFITETTETFLPTLETKPDLVILDPPRKGCQTEVIESLKQIKSNFILYISCHPATLARDLQLLCQEGDYRIMFVQPADFFPQTPHVETAVILTRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R6</accession>
    <name>K9Z5R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosylceramidase</fullName>
            <ecNumber evidence="3">3.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.45" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219642.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1813"/>
    <dbReference type="EnsemblBacteria" id="AFZ53915">
        <property type="protein sequence ID" value="AFZ53915"/>
        <property type="gene ID" value="Cyan10605_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1813"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1924"/>
    <dbReference type="eggNOG" id="COG4354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006322_1_0_3"/>
    <dbReference type="OMA" id="HDLGAPN"/>
    <dbReference type="OrthoDB" id="139229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014551">
        <property type="entry name" value="B_Glucosidase_GBA2-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028944">
        <property type="entry name" value="Beta_gluc_GBA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydr_116N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF608" evidence="1">
        <location>
            <begin position="417"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="802" mass="91278" checksum="1D92138A2D305A99" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R8</accession>
    <name>K9Z5R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219812.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1993"/>
    <dbReference type="EnsemblBacteria" id="AFZ54087">
        <property type="protein sequence ID" value="AFZ54087"/>
        <property type="gene ID" value="Cyan10605_1993"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1993"/>
    <dbReference type="eggNOG" id="ENOG5032RRI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137322_0_0_3"/>
    <dbReference type="OMA" id="WYRTIIK"/>
    <dbReference type="OrthoDB" id="1813584at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17912" checksum="55E51E24573318DB" modified="2013-03-06" version="1">MLRQFSDLTLEVDGRYAQDYELQFLEDYLDSHQLRMSAYIKIRDNAQAICDRVKEEKQKLHPNWKDYYVTCLRDMVDLLRYSATALLFDDMERLRTNMLLWFQTISRAYNFTDDNIETYDLLLKVVPEFLTPEEAKYAIPAFELNCAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z601</accession>
    <name>K9Z601_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220292.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2488"/>
    <dbReference type="EnsemblBacteria" id="AFZ54569">
        <property type="protein sequence ID" value="AFZ54569"/>
        <property type="gene ID" value="Cyan10605_2488"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2488"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112860_0_0_3"/>
    <dbReference type="OMA" id="EPMGRTD"/>
    <dbReference type="OrthoDB" id="1346306at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="205" mass="23022" checksum="E7697CD08D28A618" modified="2013-03-06" version="1">MNIESIVTNRDYTLIIDKSGSLNSDDGKGKTRWEIAQESTIALAKKCDELDSDGITVYLFSGRFRRYDNVNSDKIREIYAQNEPMGSSDLKSVLQDALDNYFQRKAEGKAKENGETILVITDGIPDEPKEIIRLIINASQKIDRDEELGISFIQIGQDVKAKEYFKALDDLLQEAGAKFDIVDTITMDDLDNMSLTDVLLNAVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z624</accession>
    <name>K9Z624_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220317.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2513"/>
    <dbReference type="EnsemblBacteria" id="AFZ54594">
        <property type="protein sequence ID" value="AFZ54594"/>
        <property type="gene ID" value="Cyan10605_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2513"/>
    <dbReference type="eggNOG" id="ENOG50314X7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099250_1_0_3"/>
    <dbReference type="OMA" id="SWDKEPG"/>
    <dbReference type="OrthoDB" id="1977258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021855">
        <property type="entry name" value="PAM68-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34575">
        <property type="entry name" value="PTHR34575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11947">
        <property type="entry name" value="DUF3464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="18157" checksum="9740FF6CF49A6963" modified="2013-03-06" version="1">MPSPANRNSLPFEPKKSKNKKVNDKNLSQPKETQRNQTESKVAKSNKGGNSLQGIPEVVSKRMVRRMAVFSGIPTAMGIFSFFAFYAIVSQEWFKIPNTAVLLVSMGLFGLGVLGLSYGILSTSWDEERVGSWWGWSEFVLNFGRFTSAWRNNRQKSLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z662</accession>
    <name>K9Z662_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO and MBR like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219790.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1970"/>
    <dbReference type="EnsemblBacteria" id="AFZ54065">
        <property type="protein sequence ID" value="AFZ54065"/>
        <property type="gene ID" value="Cyan10605_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1970"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2091"/>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117162_0_0_3"/>
    <dbReference type="OMA" id="LPYALWG"/>
    <dbReference type="OrthoDB" id="1679387at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17925" checksum="6F711EF9FF074AD5" modified="2013-03-06" version="1" precursor="true">MLLPSWLVIGAIALLLSIVINRIPADDLRWFFRLKRPSWLTFEFLIPFIWIFIFVCLVLSASLVWDSNINLFPKIMLMSSYAILQVSILAYTRVMCAVRSLVVGTAIGAFGFFIGLILAFFVAKVDSSALTLLMPYLLWSPIGTYVTWAMIPLNRNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z675</accession>
    <name>K9Z675_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219635.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1806"/>
    <dbReference type="EnsemblBacteria" id="AFZ53908">
        <property type="protein sequence ID" value="AFZ53908"/>
        <property type="gene ID" value="Cyan10605_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1806"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1916"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="218" mass="24075" checksum="0354B5F59449E5D0" modified="2013-03-06" version="1">MSKSDIAIAVENLRFSWSPQTSVLNSCSLTVPKGELWMLLGNNGCGKSTLLRLLANLLIADEGHIYTDSPLGFVFQNPDHQLVMPTVAADIAFGLVSEKLSLSQIKVRVREALCAVNLLELEDRPIYALSGGQKQRIAIAGAIARHCQVLLLDEPTALLDPDTQIELVALVQKIVKERNITALWVTHRLEELNYADGYFLLKEGKVVSQGNPRELFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B4</accession>
    <name>K9Z6B4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ordered locus">Cyan10605_2642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2642"/>
    <dbReference type="EnsemblBacteria" id="AFZ54716">
        <property type="protein sequence ID" value="AFZ54716"/>
        <property type="gene ID" value="Cyan10605_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2642"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2807"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_3"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="34547" checksum="C6B7D2AC73A12AFA" modified="2013-03-06" version="1" precursor="true">MREIDQKLIVICGATASGKSALALEIAQKLDTLIISADSRQVYRDFDIGTAKPSPLEQKLVPHYLIDICHPQEVLTVAQYQGYAQDIIEKSRSIPLMVGGTGLYIKSVTKGLKIPPVAPQAKLRSQLETYSQQERYAFLQKIDPISCEKIHPNDDTRTIRALEVYYVTGKTISAQQGENPPSYPILHLGLHCEREFLRQRIATRTKKMLEMGLVEETEFLISKYDIDLPLLNTLGYAEIKQYLQGEISLSEAQDLIITHTCQFAKRQQTWFNGYPEIVWLDVSSSQLVPNAWEKIYQFIHKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L7</accession>
    <name>K9Z6L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220558.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2768"/>
    <dbReference type="EnsemblBacteria" id="AFZ54836">
        <property type="protein sequence ID" value="AFZ54836"/>
        <property type="gene ID" value="Cyan10605_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2768"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2939"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_0_0_3"/>
    <dbReference type="OMA" id="IRLQPNY"/>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938690" evidence="1">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="234" mass="25072" checksum="C355EEB4D99381AE" modified="2013-03-06" version="1" precursor="true">MLFNQSKLLLTIGCFGLLSMQPVLAQEQMLKTITVTGEGIERIPTTIANVQLGVEIQGENASQVQEEVAQKSNSLVNLLKSRSVQRLQTSGIQLSPNYSYNDNQRKLIGYVATNLVSFELPIDKVGAVLDESVKVGATRIDNVTLSAEEDAIASAQEKALVKATASAQKQANVILQTLNLTAQEIVTINVNGANSPNPVMMPKMRSAMDASVANTPVVGGEQTVSASVTLQIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P0</accession>
    <name>K9Z6P0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoamylase</fullName>
            <ecNumber evidence="5">3.2.1.68</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.68" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219940.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2127"/>
    <dbReference type="EnsemblBacteria" id="AFZ54215">
        <property type="protein sequence ID" value="AFZ54215"/>
        <property type="gene ID" value="Cyan10605_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2127"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2263"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_3"/>
    <dbReference type="OMA" id="WVTEMGV"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019156">
        <property type="term" value="F:isoamylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="158"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="688" mass="79019" checksum="09669516C5BD4E23" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R3</accession>
    <name>K9Z6R3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219813.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1994"/>
    <dbReference type="EnsemblBacteria" id="AFZ54088">
        <property type="protein sequence ID" value="AFZ54088"/>
        <property type="gene ID" value="Cyan10605_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1994"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2117"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568819_0_0_3"/>
    <dbReference type="OMA" id="GMCSTCH"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="17721" checksum="C158F4C5D8F14C9D" modified="2013-03-06" version="1">MAKTIRLDPLGKETAIKTNDNLLSGLLKNELNVMQECGGRGMCSTCHVYIKEGMESLSPLNRREKRTLEVITTCKMNSRLACQARVIGDGVVVELPSGMYLSQIDDVESLIGRRAQQNILHPISGKILVEEGKLITRSMITQLSDTKGEVSKYLAQSVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U5</accession>
    <name>K9Z6U5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Photosystem II protein D1</fullName>
            <shortName evidence="16">PSII D1 protein</shortName>
            <ecNumber evidence="16">1.10.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Photosystem II Q(B) protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">psbA</name>
        <name evidence="19" type="ordered locus">Cyan10605_2194</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2</text>
            <dbReference type="Rhea" id="RHEA:36359"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.10.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="16">The D1/D2 heterodimer binds P680, chlorophylls that are the primary electron donor of PSII, and subsequent electron acceptors. It shares a non-heme iron and each subunit binds pheophytin, quinone, additional chlorophylls, carotenoids and lipids. D1 provides most of the ligands for the Mn4-Ca-O5 cluster of the oxygen-evolving complex (OEC). There is also a Cl(-1) ion associated with D1 and D2, which is required for oxygen evolution. The PSII complex binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cellular thylakoid membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="16">Tyr-164 forms a radical intermediate that is referred to as redox-active TyrZ, YZ or Y-Z.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Cyanobacteria usually contain more than 2 copies of the psbA gene.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Herbicides such as atrazine, BNT, diuron or ioxynil bind in the Q(B) binding site and block subsequent electron transfer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16 17">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.9" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220005.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2194"/>
    <dbReference type="EnsemblBacteria" id="AFZ54280">
        <property type="protein sequence ID" value="AFZ54280"/>
        <property type="gene ID" value="Cyan10605_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2194"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2331"/>
    <dbReference type="eggNOG" id="ENOG502Z9WG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054206_1_0_3"/>
    <dbReference type="OMA" id="IGIWCYL"/>
    <dbReference type="OrthoDB" id="586809at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:chlorophyll binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:oxygen evolving activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
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        <property type="term" value="P:response to herbicide"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PSII_PsbA_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
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        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005867">
        <property type="entry name" value="PSII_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PTHR33149"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REACTNCENTRE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="SSF81483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="13 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 16" id="KW-0359">Herbicide resistance</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 16" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="16" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_5023445951" description="Photosystem II protein D1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Quinone (B)" evidence="16">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>ChlzD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
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        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[CaMn4O5] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:189552"/>
        </ligand>
        <ligandPart>
            <name>Mn</name>
            <dbReference type="ChEBI" id="CHEBI:18291"/>
            <label>1</label>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>PD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="site" description="Tyrosine radical intermediate" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes free radical intermediate" evidence="16">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022646"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ54280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="347" mass="37940" checksum="EDBFC01CB4F19526" modified="2013-03-06" version="1">MANIAQNSSSLNYDSLWDRFCRWITSTNNRIYLGWFSVLMIPTAFVAAIAFIIAFVAAPGVDVDGIREPVMGSLLSGNNIATAAVVPTSAAIGLHFYPLWEAGSIDEWLYNGGTYQMIIFHFLIAVWAYLGRLWELSERLGMRPWIAIAFSAPAAAVTSVLLVYPIGQGSFSQGMPLGIVGTFNFMIVLQAEHNILMHPFHMLGVAGVLGGALLSVMHGSLVTSSLIRETTEDISQNEGYQFGQQEMTYNLIAGHVGYLGRLLIPSLAFNNSRSVHFLLAIFPTIGIWFASLGISSVAFNLNGFNFNHSILDSNNHVIPTDADMINRANLGFEAMNAPNTHNFPNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z5</accession>
    <name>K9Z6Z5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.3091"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DO-GTPase2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="37780" checksum="8E8E3718EC245C4A" modified="2013-03-06" version="1">MLSRILQPLIKKQTLKVTMLGHAGVGKTSLLCAMYDQFDQIIGKTNLQLTPDDDTKTILDQRLKQLKESAQQNSIKIRGGLESTTTARTYNFDLGKTGVTPSIELQFQDYPGDYCVNENLQEVEKFIKESVAIIIAIDTPALIENNSQWHEELNQPQVIYDLFKSSFADLDSPKLVIFAPVKCEKYLRESTGENQLVTTIQEKYSNLLSFFRSDALVPHVAVVMTPVETLGSVDFSRVEEDQNHQPIFYFRKPNPNLFYEPKNSDQPLRYLLRFLLKLHLQKRKMSFLELIFMMLDRDKTFLNAMSEFSNGCRNNGAFTIFQGANLLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z702</accession>
    <name>K9Z702_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2852"/>
    <dbReference type="EnsemblBacteria" id="AFZ54919">
        <property type="protein sequence ID" value="AFZ54919"/>
        <property type="gene ID" value="Cyan10605_2852"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2852"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3031"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154867_0_0_3"/>
    <dbReference type="OMA" id="LVWNING"/>
    <dbReference type="OrthoDB" id="1608722at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="263" mass="29538" checksum="32FE0A80F44F2EBB" modified="2013-03-06" version="1">MPLRVEYIQSLHYLLPLTHFLSMIPKIVNPLNYPLAVFVAGVCLFFGVRFANVSSFLMLPISISVGVIGSGFLANNSLNNDNKINLDNRALEEELELAKQESNLLIKKAENLRLEAKNLLHDAHQMDLLTAIEYGCDRTFELPEKIEYLSKKLSGSDSLLSEEELEEKLKTNLKKQQSANGLALKQLRQIESNLRRNIDLAKQGKSAREAQVFALTNILTESAGVLQQLQNKLRTSDLTNSQALQDLQDLTQELSSLLTMNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z741</accession>
    <name>K9Z741_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4351 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2306"/>
    <dbReference type="EnsemblBacteria" id="AFZ54390">
        <property type="protein sequence ID" value="AFZ54390"/>
        <property type="gene ID" value="Cyan10605_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2306"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2450"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071039_1_1_3"/>
    <dbReference type="OMA" id="WILVHIE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025587">
        <property type="entry name" value="DUF4351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14261">
        <property type="entry name" value="DUF4351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4351" evidence="1">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="41201" checksum="D56C9BCBB8D58B58" modified="2013-03-06" version="1">MSSYLNKYLQNNLNPETYRIVMTEINANYDEPWKEAIGEYFDRFLEFFFPQVYHLIDWLKPPISLDKELQKITADSDDSKRLVDKLFQVWLKNNQPVWILVHIEVQSQYDSDFNQRMFIYHYRTFDLYRKPVISLAILGDEKEKWRPSNYGYDLGGCKLNLDFPVIKLLDYQEKWEELERDLNPFAIMIMAHLKTKTTTSNLTEREQWKWYLIRSLYDKNFSKLEIVKLFKFIDAMMTLPPLLQQSLNKKVIEYEEEKVMPLISPFEQMAEERGLAKGLEKGLEQRIEKEKELIIRLLTRKLGTINTDLQTQVKALNIEDLETLAEDLFDMNSIEDLQQWLSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z750</accession>
    <name>K9Z750_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220693.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2912"/>
    <dbReference type="EnsemblBacteria" id="AFZ54974">
        <property type="protein sequence ID" value="AFZ54974"/>
        <property type="gene ID" value="Cyan10605_2912"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2912"/>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166740_4_1_3"/>
    <dbReference type="OMA" id="FDERNYV"/>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8054" checksum="B75F45A4DB69F946" modified="2013-03-06" version="1">MKINYYSDTDSLYIHLSDQPSIDSQEISEGVVLDYDEKGNLVGIDIDNASKKVQLNELILNQLPSNIMKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I8</accession>
    <name>K9Z7I8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220400.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2602"/>
    <dbReference type="EnsemblBacteria" id="AFZ54677">
        <property type="protein sequence ID" value="AFZ54677"/>
        <property type="gene ID" value="Cyan10605_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2602"/>
    <dbReference type="eggNOG" id="ENOG5033MZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992955_0_0_3"/>
    <dbReference type="OMA" id="IVILEQY"/>
    <dbReference type="OrthoDB" id="1864931at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938645" evidence="2">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="29780" checksum="97B06765407EDC64" modified="2013-03-06" version="1" precursor="true">MKKLSPLIILSLLLLSGCGVFGGGGSDNQANITPTPPQQPTPDGENQQENPEETVIEENMGSTNSVPNALIPSTNPKERLNQISQGRGDPFGSIRPPAVVKVSASQPVPPSAVAKAILREPVSNVSEGVNNAGNSNTASGRNSQNPTLSKDGTPISDQKFDAEGNVIPYAPPEPKEAESIVISGIADLQGQNIAFVTTPWDNMTRSVRVGDTLSSQDSGVMIRVKDIRFTYPQTIALRDNNQIVYQNINDSNGIVVLEQYGQQVTKEIVGVQQDPVESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P4</accession>
    <name>K9Z7P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Clan AA aspartic protease, AF_0612 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220465.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2668"/>
    <dbReference type="EnsemblBacteria" id="AFZ54742">
        <property type="protein sequence ID" value="AFZ54742"/>
        <property type="gene ID" value="Cyan10605_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2668"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2833"/>
    <dbReference type="eggNOG" id="COG3577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153957_0_0_3"/>
    <dbReference type="OMA" id="HELRSCE"/>
    <dbReference type="OrthoDB" id="1701901at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022274">
        <property type="entry name" value="Peptidase_asp_AF0612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03698">
        <property type="entry name" value="clan_AA_DTGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="13715" checksum="094842BEEE44AF27" modified="2013-03-06" version="1">MGLVFSEIQLRNPSKSNLQPIKVNALADSGAVHLCIPEHIKIQLQLNEVDQKEVTLADGSRKLIGYVGPIEIKFKNRIGFSGALVMGDQVLLGAIPMEDMDLIIIPSNRKLDVNPNSPNIASSIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S0</accession>
    <name>K9Z7S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220172.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2365"/>
    <dbReference type="EnsemblBacteria" id="AFZ54448">
        <property type="protein sequence ID" value="AFZ54448"/>
        <property type="gene ID" value="Cyan10605_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2365"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_4_3"/>
    <dbReference type="OMA" id="MSPKYPV"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8321" checksum="2E2B336536550546" modified="2013-03-06" version="1">MGKLRILSGKEVCQILATYGFKQIRQKGSHIIMQKIIENGTITVPIPNHDTIRMGTLQSIIRQSQIPRKEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U3</accession>
    <name>K9Z7U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2385"/>
    <dbReference type="EnsemblBacteria" id="AFZ54468">
        <property type="protein sequence ID" value="AFZ54468"/>
        <property type="gene ID" value="Cyan10605_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2385"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2531"/>
    <dbReference type="eggNOG" id="ENOG502Z9KQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083821_0_0_3"/>
    <dbReference type="OMA" id="FDQRQQN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045398">
        <property type="entry name" value="DUF6515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20125">
        <property type="entry name" value="DUF6515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="317" mass="34881" checksum="89ACE9E0E737AD40" modified="2013-03-06" version="1">MLVKNWWAIPTLQTLYLQEFIMKLTNKPFIFIITVLLTILTILSDVAYAGRGGGRGGGGRSGGGARTSSVQRSSSSRSSRGGGASPRVSSGTSLQNRGNLSNSSSRQSSRQSSRSNAQSNRNDVRSDRQSTRQTNQGDRQSNRSDAQSNRQDNAANRQDDRSQNQGNRQENRTDRQGNRQDGMTNRQNNRQDFVNDNWYGGGWYGGGYYTPPGWGAWAGLAGLTTGLIIGATVNETPPYYDTVYIGSSSYIYSDGVYMQPVNDNYIVVAPPTGVVVNYLPDGCTLIQDGDFQYYDCAGIYYEAVYQDGATVYRVIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X2</accession>
    <name>K9Z7X2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ordered locus">Cyan10605_3185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220952.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3185"/>
    <dbReference type="EnsemblBacteria" id="AFZ55234">
        <property type="protein sequence ID" value="AFZ55234"/>
        <property type="gene ID" value="Cyan10605_3185"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3185"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3395"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_3"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="355"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="427" mass="46093" checksum="03CB7D2E1D508D8B" modified="2013-03-06" version="1">MSKTNLEFLADTDPAIAEIIANELQRQRGHLELIASENFTSPAVMAAQGSVLTNKYAEGLPGKRYYGGCKFVDQAEDLAIERAKQLFGAAMANVQPHSGAQANFAVFLTLLNPGDKIMGMDLSHGGHLTHGSPVNVSGKWFEVCQYGVSKETERLDYDQIRELALKERPKLIICGYSAYPRIIDFEKFRAIADEIGAYLLADIAHIAGLVATGHHPNPVPHCDVVTTTTHKTLRGPRGGLILTRDAELGKKLNKSVFPGTQGGPLEHVIAGKAVAFGEALKPEFKTYCGQVIANSKALGNQLVNRGFKLVSGGSDNHLNLVDLRSIGMTGKVADQLLGEISITANKNTVPFDPESPFVTSGIRLGTPAETTRGLTEEDFTEVANIIADCLLNPDDADVKANCIKRVEALCDRYPLYPHLQIPVPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z816</accession>
    <name>K9Z816_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221054.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3290"/>
    <dbReference type="EnsemblBacteria" id="AFZ55336">
        <property type="protein sequence ID" value="AFZ55336"/>
        <property type="gene ID" value="Cyan10605_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3290"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3505"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_3"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="40021" checksum="A4E90BBCEFED3AD6" modified="2013-03-06" version="1">MGKRNLLVTGGAGFIGSNFVSYWHDKHSEDNIVVLDALTYAGNLNNLSSLKDSPCFTFVHGNICDRTLVEKILEDYSINTVAHFAAESHVDRSIYSPETFINTNVIGTFTLLETFRIHWLKHNQSSDYRFLHVSTDEVYGSLSPEDPAFTENTPYAPNSPYSASKAGSDHLARAYYHTYKLPTIITNCSNNYGAFHFPEKLIPLMCINILLGKPLPVYGDGQNIRDWLYVGDHCSALDTVINYGVAGETYNIGGNNEVKNIDLVNIICQIMDEIAPSLPVKPSQELITFVKDRPGHDRRYAIDSSKIQRELGWKPQATLESGLRTTLQWYVDNPQWWQPLLSEDYQKYYAQVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z820</accession>
    <name>K9Z820_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220433.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2636"/>
    <dbReference type="EnsemblBacteria" id="AFZ54710">
        <property type="protein sequence ID" value="AFZ54710"/>
        <property type="gene ID" value="Cyan10605_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2636"/>
    <dbReference type="eggNOG" id="ENOG5032TXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120382_0_0_3"/>
    <dbReference type="OMA" id="RGSAKQH"/>
    <dbReference type="OrthoDB" id="1531522at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="16130" checksum="7DA6318C30AC549E" modified="2013-03-06" version="1">MKLSEQIQDQEIRLNIAQDCVELMEAQVEAKTGVTGILFKTLYKGIKSISPNYAQKAIFGLIPPISQAINPLWDEGIEKGNPVTYLQSNPTLTANTILSVTDGRIQKTANKIIKVSYEKIRNSLQDEIEQVVPQLAEILGKYANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z848</accession>
    <name>K9Z848_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220463.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2666"/>
    <dbReference type="EnsemblBacteria" id="AFZ54740">
        <property type="protein sequence ID" value="AFZ54740"/>
        <property type="gene ID" value="Cyan10605_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2666"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2831"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345782_0_0_3"/>
    <dbReference type="OMA" id="ELYILEM"/>
    <dbReference type="OrthoDB" id="209140at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="308"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="910" mass="106889" checksum="EDCFB052996AF129" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z884</accession>
    <name>K9Z884_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2712"/>
    <dbReference type="EnsemblBacteria" id="AFZ54785">
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        <property type="gene ID" value="Cyan10605_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2712"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2878"/>
    <dbReference type="eggNOG" id="COG5464">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069065_0_0_3"/>
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    <dbReference type="OrthoDB" id="987684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022573">
        <property type="entry name" value="DUF2887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11103">
        <property type="entry name" value="DUF2887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="268" mass="31362" checksum="4D7BDA7359DC0ED5" modified="2013-03-06" version="1">MKTDSIFYELFANLPETFFALLNLPNNVVQEYKFCSQELKQLAKRIDGVFLPQTETKPIYFVEVQFQKDENLYHRLFTEIFVYLGQYKPVQDFRAVVVWADEKMDYSLPVYYQFFQDMGKVDIIYLNQLNVNPSKDIGLEIIKLIVSSEDQAKTQVDYLFNLAQTNVETETKQKDIIELVEKILVYKFTNYSLEELDKMFTLSDFKKTKFYQDTFSQGKIEGEIEGKIKTIPNLVRLGLTPEQIAEALDLSLDLINQLTEHNNQGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A9</accession>
    <name>K9Z8A9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55431">
        <property type="protein sequence ID" value="AFZ55431"/>
        <property type="gene ID" value="Cyan10605_3389"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3389"/>
    <dbReference type="HOGENOM" id="CLU_1632635_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938652" evidence="1">
        <location>
            <begin position="33"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="16224" checksum="D34BEA28B73E93A0" modified="2013-03-06" version="1" precursor="true">MIKNLLKYSSVAIAGVTALSLPILMSQNSAQAGQGGLAAAVSFTVDSNQNVNGVAAAVGIGKTDAAASAFFEVDPVDGFFNGSATALGSSSPITIDEINAIDINFIESSGDRGDRDLDIAQENEIDGLALIASNGDLIGGGVITFGSVIDAFTDGGGLLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E7</accession>
    <name>K9Z8E7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55002">
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        <property type="gene ID" value="Cyan10605_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2940"/>
    <dbReference type="eggNOG" id="ENOG5032SJK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064424_0_0_3"/>
    <dbReference type="OMA" id="MIPANSP"/>
    <dbReference type="OrthoDB" id="1958921at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29159" checksum="F89616CE42450B4C" modified="2013-03-06" version="1" precursor="true">MLYPHRLISFVCLSIFSSTPLIFSPKVEAQNVSVSEDNSVMEIAQATQADMLYNQMNQYMGAAFQGIPVFANGLGQMQTMQNEQQLYTLLQQLIPIATNVAGNFNQAYQIGQQLTPMIPANSPYATIVQQWTLLNGQGANTFASWIDTLMPMQQALQTQNVSQMESAIAQMQNAVNQTITLANGLQAVTQQTNNILASYQNAQATANSVNYGNDMTMAEYEMMSRMSNMMHETNMSIINNMGSDGEWRYNYSTGEDEYIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H2</accession>
    <name>K9Z8H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221172.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3412"/>
    <dbReference type="EnsemblBacteria" id="AFZ55454">
        <property type="protein sequence ID" value="AFZ55454"/>
        <property type="gene ID" value="Cyan10605_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3412"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3636"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024175_0_0_3"/>
    <dbReference type="OMA" id="CPYRHLV"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024012">
        <property type="entry name" value="Dnd_restrict_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04095">
        <property type="entry name" value="dnd_restrict_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="63"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="311"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="485" mass="56144" checksum="8FADFD0B6DB05EE9" modified="2013-03-06" version="1">MKTEQNTYQRELINWQKLIQIFSAKQRHKVAEKRNKYSVYPLNKYPQYPSELILRDYQNQAVINWMKNQGRGTLKMATGSGKTITALAIATELYQYINLEVLLVICPYRHLVLQWEKEAKKFNLSPLLAFQSVYNWQSDLSQQLYQIHQKKQNFLTIITTNSTFISERFQSQLPFFPQKTLIVGDEAHNLGSPRFVSCLPKNISLRLALSATPERHFDNDGTDLLIDYFGAVLQPEFTLAKALKKQALVKYNYYPILVELNQYEALKYAKLTKRIGWILSENNNLEDNPQLKSLLLQRSRLVATAENKLVALKELMQNHQNMKATLFYCGDGSMNNNEKQLAAVTRILGKELNYRVNTYTAETPIEERETIKQQLITGELQGIVAIRCLDEGIDIPMINNAVILASSSNPRQFIQRRGRILRPYKGKKEANLFDMIVIPPILERDIWQVEKSLMKKELGRLIEFAKLAKNADEAHKVLNLIQEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K7</accession>
    <name>K9Z8K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3002"/>
    <dbReference type="EnsemblBacteria" id="AFZ55062">
        <property type="protein sequence ID" value="AFZ55062"/>
        <property type="gene ID" value="Cyan10605_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3002"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3198"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_5_1_3"/>
    <dbReference type="OMA" id="RATYYIT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="163" mass="18188" checksum="B1C4170879572AD7" modified="2013-03-06" version="1">MVDLTMALFARLKVNVNETIDLLRNWKLTLFRGQKMTRYNISSGTPWESLVGYSRAVKIGPYVHVSGTTATTPEGITGIDNPYEQTIQALKNIEAALEEAGAKLTQVVRTRIYVTDISRWEEVGLAHGKFFGEIRPASSMVEVSKLISPELLVEIEADAYVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N4</accession>
    <name>K9Z8N4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220675.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2889"/>
    <dbReference type="EnsemblBacteria" id="AFZ54955">
        <property type="protein sequence ID" value="AFZ54955"/>
        <property type="gene ID" value="Cyan10605_2889"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2889"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3070"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038557_1_0_3"/>
    <dbReference type="OMA" id="FQRLFRW"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="61"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="45027" checksum="38BC1D2CF34FE190" modified="2013-03-06" version="1">MNVTLKDKKSNYDNYVIETDEDTPEEYDADNSSLYPYDPLKTDIDIRENPYTVFELKRRCDKGQIILDPEFQRNPNIWTQEQKSKFIESIILNFPLPYWYVKQTQDGKYIIVDGLQRTSAIRDFIDNNFKLTGLKTLSVLNDNYFDNLKQLKGDYETRIEDKKISLYVIPYSASSKVVYDIFERVNTGGTQLNRQEIRNCIFAGKATKLLKKLSEQEYFKQAIDYGFSPKRMKDRELILRYLAFKIFDDNEDYQGDMSDFIEEAMKKINLMSDDKIDELIKDFERVMKLTYDFFGKENFRLPNDKSRGKVNMIMFESISYFFSTHSDQFLQQHKEIIKQNFLKLRQNQEYVGFIKRVRNDKNIVIRRFDLAQQILGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R2</accession>
    <name>K9Z8R2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221266.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3516"/>
    <dbReference type="EnsemblBacteria" id="AFZ55549">
        <property type="protein sequence ID" value="AFZ55549"/>
        <property type="gene ID" value="Cyan10605_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3516"/>
    <dbReference type="eggNOG" id="COG1604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474621_0_0_3"/>
    <dbReference type="OMA" id="WRRPLHI"/>
    <dbReference type="OrthoDB" id="436319at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="585" mass="66313" checksum="1BB0CC819254D329" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S2</accession>
    <name>K9Z8S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3526"/>
    <dbReference type="EnsemblBacteria" id="AFZ55559">
        <property type="protein sequence ID" value="AFZ55559"/>
        <property type="gene ID" value="Cyan10605_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3526"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057823_2_1_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="19121" checksum="540329FE4FD937BA" modified="2013-03-06" version="1">MLDYYKNNAIKYYHNTVNIYMRSIYREFLSLLPKHCKIVDLGGGSGRDTPYFLKQGYQVTAVDGSAEMVKLSSELTGQSTFLMTFDELNYDNYFDGVWACASLLHVPRTKISTILSLIINALKFQGILYLSFKYGTEERIEANRFFCDYNEQLLADLLTDLDIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S6</accession>
    <name>K9Z8S6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220719.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2938"/>
    <dbReference type="EnsemblBacteria" id="AFZ55000">
        <property type="protein sequence ID" value="AFZ55000"/>
        <property type="gene ID" value="Cyan10605_2938"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2938"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3126"/>
    <dbReference type="eggNOG" id="COG1805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058618_0_0_3"/>
    <dbReference type="OMA" id="WVSPGQW"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="285" mass="32576" checksum="D12448DC09B66A0D" modified="2013-03-06" version="1">MKVFQDARDYQILFLSLFLSLGVVNRDWTLSPIRVVLIIIACLLVQFLCESLTHYQQKINTLINKNYNEKILESISFQGWKSALITSLGLSLLLRANDISTLVIASAIAIASKFIFKYHNKHFFNPANFGIIGVLLLTNDGWISPGQWGSDWLYLGLFLATGAMVLKKVGRWETTAVFLSTYGILEAIYNYYLGWNFEVLLHQLMTGSLLVFAFFMLSDPRSIPDGKNGRIIWAIVIAFLGFILGNLFFINNGVFWSLFIISPLTILFDLIWKGNRFRWRYSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Y1</accession>
    <name>K9Z8Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEP motif putative anchor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220550.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54828">
        <property type="protein sequence ID" value="AFZ54828"/>
        <property type="gene ID" value="Cyan10605_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2760"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2931"/>
    <dbReference type="eggNOG" id="ENOG5032WFH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111496_0_0_3"/>
    <dbReference type="OMA" id="GATHCEG"/>
    <dbReference type="OrthoDB" id="2049991at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026374">
        <property type="entry name" value="Cyano_PEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04155">
        <property type="entry name" value="cyano_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="20229" checksum="64BE05846D20DD7D" modified="2013-03-06" version="1" precursor="true">MRINSIISVSIASSTILLSLLGLSSDKVNALTLAIANTTMCSLSDLDVSIACEGAFAGNNENQDLSGLFNVSNWTQYAKVDGDSGTSNGLTVNGGGTSSTWSLTGIDFNSFDIMAILKGGPTFSAYLLDSAGLNWNTDGILKGNYKPGPGLSHFTIYTSAKTPQPVPEPLTILGTGLALGLGGLFKSKQKQKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z986</accession>
    <name>K9Z986_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRISPR-associated protein Cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220884.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3112"/>
    <dbReference type="EnsemblBacteria" id="AFZ55165">
        <property type="protein sequence ID" value="AFZ55165"/>
        <property type="gene ID" value="Cyan10605_3112"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3112"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3316"/>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063836_0_0_3"/>
    <dbReference type="OMA" id="WNDFSGL"/>
    <dbReference type="OrthoDB" id="1403079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="5">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="43368" checksum="E057B303ED183BF2" modified="2013-03-06" version="1">MNINPLSSLGNLTWTNKNDLVILEFELVAGKDYYLCFDYSKGLHAWFLDQVRQLSSDLSQRLHDYPEEKAFSISRLQGNLIESDDKILLKQNSLYTWYLSIFSQELIQWLKIWFNQFPSHLGLYHAPLQIQKVKFFSPPTTYENLWKEKIETNFCFTFLSPTSFRRNNHHYPLPHPPNLFHSYLRRWNQFSQKVFSQDSFLDWIDKFVIIRRYHLESKKVAGGKKGSVTGFIGSLELYLGHKYQDYPEFTQLYSALCRFAPYCGTGHKTTFGLGHTRLEWVDIYQNNNNSLEDKLSQRIDELVDIFLKKKNGKGGNRTKNICLNYANIIARKELRQSLKDIATELEMPYETVKTYSKRATKILSSSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E3</accession>
    <name>K9Z9E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221065.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3302"/>
    <dbReference type="EnsemblBacteria" id="AFZ55347">
        <property type="protein sequence ID" value="AFZ55347"/>
        <property type="gene ID" value="Cyan10605_3302"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3302"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3516"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107556_0_0_3"/>
    <dbReference type="OMA" id="GSYIRNW"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23454" checksum="5B04EBC4B80BE4AE" modified="2013-03-06" version="1">MLDFPPLGKQKPPKIFHKPYLTFSFFLIIGLTFGLVNPLGLSKNQSLQAQTIPVRASWRQASFPVENFQAYTSGFGYRIHPVTGQRQFHGGLDLAAPLGSYVRSWWGGQIIHLSDHTACGTMIKIRSGNWTHVYCHLMGSVEKTSQGLVLLDRSGGIILRQGQNVPSGARIGRVGMTGRTTGPHLHWELRYKGDRIDPADILRQMFAQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H8</accession>
    <name>K9Z9H8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ordered locus">Cyan10605_2983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220762.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2983"/>
    <dbReference type="EnsemblBacteria" id="AFZ55043">
        <property type="protein sequence ID" value="AFZ55043"/>
        <property type="gene ID" value="Cyan10605_2983"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2983"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3177"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_2_3"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="531" mass="57792" checksum="DFA1E56B815F814D" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K5</accession>
    <name>K9Z9K5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_3365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221125.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3365"/>
    <dbReference type="EnsemblBacteria" id="AFZ55407">
        <property type="protein sequence ID" value="AFZ55407"/>
        <property type="gene ID" value="Cyan10605_3365"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3365"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3583"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_0_3"/>
    <dbReference type="OMA" id="LHGHSWV"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14591" checksum="4CD219F34315D1EA" modified="2013-03-06" version="1">MDEWIIYKEITFEAAHKLPHHDGKCARLHGHSWKARIYVRSNHLINEGTKQGMVMDYGDIRAYVQPILDQYLDHYYLNESLGLENPTSEAIALWLYNKLESMGMPNLYAVEIQETCTAAARYMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA43</accession>
    <name>K9ZA43_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid segregation oscillating ATPase ParF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220941.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3172"/>
    <dbReference type="EnsemblBacteria" id="AFZ55223">
        <property type="protein sequence ID" value="AFZ55223"/>
        <property type="gene ID" value="Cyan10605_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3172"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_5_6_3"/>
    <dbReference type="OMA" id="HLASVWH"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="21880" checksum="3FA73F3C5D70A7A3" modified="2013-03-06" version="1">MLIAIASLKGGVGKTTTAIHLAAYLQTDQPTLLVDADRNRSALVWAREEKLPFTVASQAGSAPFMATHKHIVTDMRGGPEEDDFVDLAKGNDLMIIPTTPNHLDLDATIKAVEMLKKHNVNNYKILLTKVDSRTSNSRTAKYFLKEQNLPLFKTEIPLLIAFERASQHGKTVKDYSDDRAKVAWKKYRDVGKEIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA58</accession>
    <name>K9ZA58_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Late competence development protein ComFB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221198.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3440"/>
    <dbReference type="EnsemblBacteria" id="AFZ55480">
        <property type="protein sequence ID" value="AFZ55480"/>
        <property type="gene ID" value="Cyan10605_3440"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3440"/>
    <dbReference type="eggNOG" id="ENOG5032TXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591784_0_0_3"/>
    <dbReference type="OMA" id="YENTMEC"/>
    <dbReference type="OrthoDB" id="1935367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019657">
        <property type="entry name" value="ComFB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10719">
        <property type="entry name" value="ComFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="19736" checksum="96B8EA05C5864D93" modified="2013-03-06" version="1">MVSEPQTYKNVMEAFVQEEIEFQLQNNKALSRSADYINLLEVATFALNRLPCYYASSIEGIERQRRRIKEKRELKQKISFVVSQAFAAVERDPLRRSTPIIEEDKKDIFDEARSAVYQAKDTLPETELSWIISFMEAFLTNITYNSVSAEEVVKLYYLLYYYWQENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ23</accession>
    <name>K9YZ23_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217908.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0015"/>
    <dbReference type="EnsemblBacteria" id="AFZ52176">
        <property type="protein sequence ID" value="AFZ52176"/>
        <property type="gene ID" value="Cyan10605_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0015"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.16"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_0_1_3"/>
    <dbReference type="OMA" id="WGYTGNA"/>
    <dbReference type="OrthoDB" id="295054at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="436" mass="48342" checksum="F42D8685DDF413A5" modified="2013-03-06" version="1">MNNNFSVPSLETIKKQLHNQDLEFIEIFDWGQESPWKECIEASELKNGLPRYIIVPNTNKMLSQFLKICCKNKWRILPLGNGSKLHWGNLPSGASVLVSTHKLNKIIEHAQDDLTITVQSGMKIKDLQDFLASFNQFLPIDPIYSQFATVGGVVATANTGSLRQKYGGVRDLILGISFFRSDGEEAKAGGKVVKNVAGYDLMKLFTGSYGNLGIITEVTFRLFPVPSDSITLLLTGGQEKINQLQKKICASALTPTSADLLSESLINGLNLNFSLGLALRFQGIEESVSQQSARVKQWAEDIGLLIHQWDSEKELDLWTRLKDMVFQGANNRGIICKVGILPTKIAELFALTQGSGFVNMGTGVGYVCLPKGIKNHQVRGIRNFCQDNEGYLTVLESGASTIKQEIEPWGYVGNGLEMMKKIKSNFDPFNIFVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ37</accession>
    <name>K9YZ37_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217923.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0030"/>
    <dbReference type="EnsemblBacteria" id="AFZ52191">
        <property type="protein sequence ID" value="AFZ52191"/>
        <property type="gene ID" value="Cyan10605_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0030"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.32"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_3"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="465" mass="51527" checksum="420E0ABD4AAAD9E9" modified="2013-03-06" version="1">MSENTVTVKNDSRHELRELVSSQLQILLEQNNLEGVKALLLPVQPVDIAEAIESLPSQMQLIAFRLLNKTEAIDVYEHLDYTVQQSLIEQFKRQEVIDIVDKMSPDDRAHLFDELPASVVSRILEQLSPEERQATNLILGYEEDTAGRIMTPEYISLKQNLTVEQTLEKIRSLAPNSELVYYMYVVDQSRHLVGIVSLRDLVLHEPQQTLENIMTKDVIYVKTDMDQEEVARLIQRYDLLALPVVDKELRLVGIVTVDDVIDVLEQEATEDIYALGAVSSDGDNYFQTNLFTVARRRVTWLLVLLLTNTVTGSIIGAQEDVLTQVTVLAAFIPLLIGTGGNIGTQSSTVVIRGLSTDEISDLGPAKVVFREAIAGLLLGLILGLLATIWAYFLPQTDKNIIVSLSVGISLIAISTLASISGSALPFLFRRLGLDPALMSAPFITTAVDVLGVLIYFNIARLMLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZB2</accession>
    <name>K9YZB2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218008.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0118"/>
    <dbReference type="EnsemblBacteria" id="AFZ52276">
        <property type="protein sequence ID" value="AFZ52276"/>
        <property type="gene ID" value="Cyan10605_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0118"/>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016729_0_0_3"/>
    <dbReference type="OrthoDB" id="1419511at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="772" mass="84182" checksum="EACE50E4F194342E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZH1</accession>
    <name>K9YZH1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter, inner membrane subunit CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218078.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0190"/>
    <dbReference type="EnsemblBacteria" id="AFZ52346">
        <property type="protein sequence ID" value="AFZ52346"/>
        <property type="gene ID" value="Cyan10605_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0190"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_1_1_3"/>
    <dbReference type="OMA" id="IASFMIR"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="29513" checksum="23DF2403CAD7684C" modified="2013-03-06" version="1">MKLSLDEYVYLDSLIHRWQSKPKLIALLSLIFCFAFIQRLSFLPVIIFITVILYSLSKLPIKYLISRLRYPGIFILAVIFLLPFLVGETTIFSWGFFSIKQEGCLLILLVITRFLCIITTTLVLLGTSPFLTILKTLRSLGLSPIISDMMLLTYRYLEQMGDRILSMRRALKLKGFNFHQFSSRNLRIMSQLIGSLLVRSYDESKLVYQAMILRGYGYNSQRKNRHEQNIKISDWIACYSVVVISVSIIILQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZP7</accession>
    <name>K9YZP7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA_e1_thiolCys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218121.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0236"/>
    <dbReference type="EnsemblBacteria" id="AFZ52389">
        <property type="protein sequence ID" value="AFZ52389"/>
        <property type="gene ID" value="Cyan10605_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0236"/>
    <dbReference type="eggNOG" id="COG3597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699647_0_0_3"/>
    <dbReference type="OMA" id="QICFREV"/>
    <dbReference type="OrthoDB" id="854111at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_e1_thiolCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA_e1_thiolCys" evidence="2">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="394" mass="43269" checksum="2DC3A1CAB618BDC0" modified="2013-03-06" version="1">MKVKEIDQNILGQTTEVLINKKKAKGKIIAIADHSTHQQVCIQIEEGKMGVWIPALALVDYDKLAVSVSSNILEQVVKLPQDFFVSVQKKAEQDITSLVDFADNLAKNINNKVASDIQLINSAVEKAQKLIEKTTQEIAKSGENSIKFINQYLAETNSAIGKILNQISDIIQNFSNETFRKCIAMAMKVAEDSFDSAKKVVDKLRQEYPKEKSFKIAQRLINRSTIFSLGFGIAMDGFNFAESLTKLSIGLDLAKNAALLSELVYQIGIAYGFNDINKITKGEAIAIIALCLGIDILQQLGLKALTEPSSIVSIPIKAVSNVALFQLVGYASCLYFDIKVNGAENPLVSGKAYQQFTDKLRIYLDETLSETEKLADIVKDAISIKQQVPALATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J1</accession>
    <name>K9Z0J1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RE_BsaWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217969.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52237">
        <property type="protein sequence ID" value="AFZ52237"/>
        <property type="gene ID" value="Cyan10605_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0077"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.78"/>
    <dbReference type="eggNOG" id="ENOG5031KXF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993256_0_0_3"/>
    <dbReference type="OMA" id="DCAFIGK"/>
    <dbReference type="OrthoDB" id="1108810at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041551">
        <property type="entry name" value="RE_BsaWI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18643">
        <property type="entry name" value="RE_BsaWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RE_BsaWI" evidence="1">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28788" checksum="A6CD36FACA22E596" modified="2013-03-06" version="1">MSSLLKQEKQILKMIKSRYYMIPILSKLDEYIDKYGLEKSLDYLNKILILAKDDVEILLDKRILAGEIKDKSQARKSIAGNAFSLLIKYLFLTLKENKFIKSNVFVTSNPKQYKLISDIVTIKVDNETQKPDMDLAIYSINKENELNKCLILSLKTSLRKKSEQICAWKLLLEIATSDNPIKEKYNISYEHKNMPLVGFATVNFYDEINNPQHRGMFKFFDVAFIGKPLNAEFINNLSDLPRFVNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K9</accession>
    <name>K9Z0K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217989.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0098"/>
    <dbReference type="EnsemblBacteria" id="AFZ52257">
        <property type="protein sequence ID" value="AFZ52257"/>
        <property type="gene ID" value="Cyan10605_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0098"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.101"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_2_3"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022299">
        <property type="entry name" value="Tscrpt_reg_NtcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03697">
        <property type="entry name" value="NtcA_cyano"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="25103" checksum="09060E74E1828908" modified="2013-03-06" version="1">MQSLSMSEQPLASVFRQIGAGIYTPVVEKFERGKTIFFPGDPAERVYFLMKGAVKLSRVYEAGEEITVALLRENSVFGVLSLITGQKSDRFYHAVAFTPVELLSAPIEHFQRSLKENPELSRLMLQGLSSRILQTEMMIETLAHRDMASRLVSFLLILCRDFGIPSPSGITIDLKLSHQAIAEAIGSTRVTVTRLLGELRQENLITINKKKITVHNPVALSQQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N6</accession>
    <name>K9Z0N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase with Chase2 sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218482.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0612"/>
    <dbReference type="EnsemblBacteria" id="AFZ52751">
        <property type="protein sequence ID" value="AFZ52751"/>
        <property type="gene ID" value="Cyan10605_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0612"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.645"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013805_0_0_3"/>
    <dbReference type="OMA" id="IIPICKH"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="454"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="762" mass="85388" checksum="78934DFB6CA94722" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R7</accession>
    <name>K9Z0R7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218480.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0610"/>
    <dbReference type="EnsemblBacteria" id="AFZ52749">
        <property type="protein sequence ID" value="AFZ52749"/>
        <property type="gene ID" value="Cyan10605_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0610"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.643"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_0_0_3"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025826">
        <property type="entry name" value="Co_AT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12557">
        <property type="entry name" value="Co_AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Co_AT_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="23282" checksum="6F1025ECACD94405" modified="2013-03-06" version="1">MNKSITTEDYKKKMQRRKEVQDKRLANMKSEKGLIIVNTGDGKGKTTAALGMVMRSLGHGYKVAIIQFIKGAWEPAEKEVLEKWSGQLEFYAMGEGFTWETQDREKDILMANKAWEKAKDFILNPKYKLVLLDEINIALKLDYLNLEEVLKILQQKPQDSHVILTGRGAKKELIEMADLVTEMKLIKHPFKEQGIKAQPGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S5</accession>
    <name>K9Z0S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218527.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0658"/>
    <dbReference type="EnsemblBacteria" id="AFZ52796">
        <property type="protein sequence ID" value="AFZ52796"/>
        <property type="gene ID" value="Cyan10605_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0658"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.693"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992953_0_0_3"/>
    <dbReference type="OMA" id="IWLSRGM"/>
    <dbReference type="OrthoDB" id="1343259at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="31136" checksum="2D388A8A2DE9F84C" modified="2013-03-06" version="1">MLNTLILTILVITQVLGDVCLSEAMKIHGEITSFAPNVIIDVIYYLFTSPFFYFGLGSLTISWFIYLFAVSKMDLSYVLPIHASSYICNALLAWLILGENVSFLRWFATGFISVGVFIVGYSQYREKKKLKQLSSHVTVTPKDKVSPVFAFISSGVFLPTVWLGVIVMVLADSMGDLLNAKGMRQIATLKKFAVEDIFRWVVGIFTNLYIIIGVSCQAIALLLFLSLLSWDDLSFVRPASAVGYLITIISAKYILHEKISKGRWIGISCILLGVVTLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z106</accession>
    <name>K9Z106_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218149.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0267"/>
    <dbReference type="EnsemblBacteria" id="AFZ52417">
        <property type="protein sequence ID" value="AFZ52417"/>
        <property type="gene ID" value="Cyan10605_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0267"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.277"/>
    <dbReference type="eggNOG" id="ENOG502Z830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092370_1_0_3"/>
    <dbReference type="OMA" id="ILESFHC"/>
    <dbReference type="OrthoDB" id="1564747at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="27250" checksum="D20734C43E2376A2" modified="2013-03-06" version="1">MLLGKFDTIGEKTINKIAEMAFKSQIKSAKYLSVQVKTNPQQLAKGILESLDIDGNGLMMRENLPLEKMRITLNDIAVSPFKALMGNVELTQPSRGKARIILNETDIETILNVDNLNSKLGQYPTASKVFFKRVDFRILSDGRIAIKAKLKEQNSNKLESICLIIKPRICQHKKGIILDEFACTQGESWSATVVKILLAEVGKVLNLENLLIDGIYLQVDKISISEGKLNLFANAGITHLPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z147</accession>
    <name>K9Z147_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyanobacterial porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218017.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0128"/>
    <dbReference type="EnsemblBacteria" id="AFZ52285">
        <property type="protein sequence ID" value="AFZ52285"/>
        <property type="gene ID" value="Cyan10605_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0128"/>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018575_1_0_3"/>
    <dbReference type="OMA" id="YHLEGLY"/>
    <dbReference type="OrthoDB" id="1383921at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939033" evidence="2">
        <location>
            <begin position="33"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="578" mass="62422" checksum="9C4C9A056C905457" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z169</accession>
    <name>K9Z169_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">Cyan10605_0776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218640.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0776"/>
    <dbReference type="EnsemblBacteria" id="AFZ52909">
        <property type="protein sequence ID" value="AFZ52909"/>
        <property type="gene ID" value="Cyan10605_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0776"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.817"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_5_2_3"/>
    <dbReference type="OMA" id="GIEATDY"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="459" mass="50650" checksum="3543B4A7D56B61FC" modified="2013-03-06" version="1">MFNWFRRKKENKENIEQKPPVVEDKQSNAPSETSEIQSQPSLEWAKAAYANIQKQKQEIPENSEDERVASVENNLSAEEKNVDSSSMVEEKTEEVKENAPAWMQKSDRLSALKETAIETEKEEETTLDEDFVWSAQVLESQGRTPDDVSEEEFTWLRKLRQGLGKTRRNFVNQLKSVIGQGPLNQNAIEQIEAMLYSADVGYEATEYIVNTLQNKLKEESIASEDAIASLKEILQQVLDEPLQKLTKTEFEPEAGKLNIWLLTGVNGVGKTTTIGKLAHLAKTSGYNCVIAAADTFRAAAVEQVKVWGERTNTPVIANEGKNTDPAAVVFDGINAAIARNADILLVDTAGRLQNKKNLMEELAKIRRIIDKKAVDANIESLLVLDATLGQNGLKQAQVFSEAAQLTGVVLTKLDGTAKGGVALGVSRDLGLPIRFIGAGEGIEDLRPFSSYEFVEALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z177</accession>
    <name>K9Z177_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218218.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0340"/>
    <dbReference type="EnsemblBacteria" id="AFZ52487">
        <property type="protein sequence ID" value="AFZ52487"/>
        <property type="gene ID" value="Cyan10605_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0340"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.356"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_3"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="412"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="59290" checksum="9822065C95129CC8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B9</accession>
    <name>K9Z1B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52527">
        <property type="protein sequence ID" value="AFZ52527"/>
        <property type="gene ID" value="Cyan10605_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0382"/>
    <dbReference type="eggNOG" id="ENOG5033BV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181367_0_0_3"/>
    <dbReference type="OMA" id="RKITIMN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7257" checksum="92935EA2DBC5D60B" modified="2013-03-06" version="1" precursor="true">MLFSGIMTALIGLMLGLAVSEISQRVHRRNIVIIGGGVLGFVLGFTYQGIKQEKDERQKEYEDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C8</accession>
    <name>K9Z1C8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218107.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z1C8"/>
    <dbReference type="STRING" id="755178.Cyan10605_0221"/>
    <dbReference type="EnsemblBacteria" id="AFZ52375">
        <property type="protein sequence ID" value="AFZ52375"/>
        <property type="gene ID" value="Cyan10605_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0221"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.230"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_3"/>
    <dbReference type="OMA" id="TMAPHSE"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="466" mass="53491" checksum="5F81F6A58F71E23B" modified="2013-03-06" version="1">MALSEKDFIREYINDDIYASVDLSKAMPKYRFPDKENEPRHVYQLIHDELMLDGNARQNLATFCQTWLEPEVHQLMDECIDKNMVDKDEYPQTAELESRCVHMLADLWNSPDAVNTMGCSTTGSSEAAMLGGLAMKWRWRKKMEAQGKPTDKPNLICGPVQICWHKFARYWDIELREIPMEENRLLMTPEEVIKRCDENTIGVVPTLGVTFTCGYEPVKAVSDALDKLQDEKGWDIPIHVDGASGAFLAPFCVPELEWDFRLPRVKSINTSGHKFGLAPLGCGWIIWRDKEDLPEELIFKVNYLGGEMSVFALNFSRPGGQIICQYYNFLRLGKEGYRKIQMACYETAQYLAEEIAKMEPFEILYNGDEKSGIPAISWKIKDGYDTKGYTLYDFADRLRSRGWQVPAYSLPANCQHMVIQRILVRHGVSRDLASLLVEDMKRCLDYLDKHPISKPLTAQEATGYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E0</accession>
    <name>K9Z1E0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218752.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0891"/>
    <dbReference type="EnsemblBacteria" id="AFZ53021">
        <property type="protein sequence ID" value="AFZ53021"/>
        <property type="gene ID" value="Cyan10605_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0891"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.936"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_2_1_3"/>
    <dbReference type="OMA" id="TWLWVKL"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="324" mass="36870" checksum="643751D6B729B6AF" modified="2013-03-06" version="1">MPIYYFWGDDDFTMMQEINALKEKNLDLNWLQFNFEKFAGDKEEFIREAFLQAMTPPFGSGDRIVWLVNTTICQSCSEDLLTEIQRTIKQIPDTTHLLLTSEKKPDGRIKSTKLVNQYAQVKEFSLIPPWQTDILIKKVEGMVAQKELKITKEGIKILANCVGNDSRLLWQELDKLSLYQGENKQPINEEIVKSLVNVSNQNSLQLAQAILQQNIPLALQLVQDLISLNEPALRIVATLVGQFRTWAIVKTMVESGEKDEKAIAENADISNPKRIYFLKQETKNISAQKLLSSLPILLELEANLKSGHDPLIALETKIIQLCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F3</accession>
    <name>K9Z1F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase, type 2</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218293.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0418"/>
    <dbReference type="EnsemblBacteria" id="AFZ52562">
        <property type="protein sequence ID" value="AFZ52562"/>
        <property type="gene ID" value="Cyan10605_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0418"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.442"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_1_3"/>
    <dbReference type="OMA" id="TYVPQCT"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15721" checksum="A2297E040367453F" modified="2013-03-06" version="1">MAKTQTQNKTQEIHSTTSHPHKSEIQVTETRPWGSFTTLEEGFGYKIKRIEVNPGHRLSLQMHHHRSEHWIVVSGTAKVVCGDEEKILAANQSTYVPQCTAHRLENPGVIKLVIIEVQNGEYLGEDDIIRFQDDYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J3</accession>
    <name>K9Z1J3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218765.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53034">
        <property type="protein sequence ID" value="AFZ53034"/>
        <property type="gene ID" value="Cyan10605_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0904"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.949"/>
    <dbReference type="eggNOG" id="COG3542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088365_0_3_3"/>
    <dbReference type="OMA" id="ERSHWHR"/>
    <dbReference type="OrthoDB" id="1565693at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="19393" checksum="55C0A04F75C9B460" modified="2013-03-06" version="1">MTKNAQYWIDKLDLQKHPEGGYYRENYRCLDMVNNDNFLAKYNGARNASTAIYYLLLNDEFSAFHLLKSDEIFHFYSGSSLDVHIINSQGDYQLIKLGNNPEENEVLQLVIPQNSWFAAAVSQPNSYSLIGCTVAPGFDFNDFTLGKKEDLLKIFPQHQTIIERFTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R9</accession>
    <name>K9Z1R9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218040.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0151"/>
    <dbReference type="EnsemblBacteria" id="AFZ52308">
        <property type="protein sequence ID" value="AFZ52308"/>
        <property type="gene ID" value="Cyan10605_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0151"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.157"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023761_0_0_3"/>
    <dbReference type="OMA" id="LGGDQFW"/>
    <dbReference type="OrthoDB" id="497029at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="47223" checksum="3AD1F83CE4E1CBEF" modified="2013-03-06" version="1">MDSYFDLVILSNGPGEITTWVLPIVKQIRSLSTINQENLRISLILSPCPHATGNEVNIARKLPEINRILGAENFFSFLLWGKTIDNWEWYQRGLVLFLGGDQFFTVVIAKRLGFLSLVYAEWDARWYKYIDYFALMQQSILDKIPSYFHGKCHLVGDLMADITSNNLQNIGSNETVKIGLLPGSKSAKLTQGVPFLMAIASYIYKYSNNVEFIIPVAPTITPEILASYGKKENNNLIEQLGNITGELITINKQLYLQTSDGIKIKLITKFPCYEEITQCQLCLTTVGANTAQLGSLTMPMIVLIPTYQLTAMKSWDGILGLLANLPIIGDYFAKLINWIVIQYTVKNKKLYAWPNIWAKKEIVPELIGHLKVEEVGNLVLDLLNNEDKLKQIKSDLQKLRGSAGASEKISQIVANVINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V1</accession>
    <name>K9Z1V1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">Cyan10605_1010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1010"/>
    <dbReference type="EnsemblBacteria" id="AFZ53139">
        <property type="protein sequence ID" value="AFZ53139"/>
        <property type="gene ID" value="Cyan10605_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1010"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1068"/>
    <dbReference type="eggNOG" id="COG1586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_0_3"/>
    <dbReference type="OMA" id="HTWPEKG"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023381700" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023381701" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="146" mass="16202" checksum="9A04B065FA95BA52" modified="2013-03-06" version="1">MSLLAKTVWSELRRMNKVGTHLVVDAWQAPADLLNSPERIRQGLLDAIEAGKATLIDICVHQFSPHGVTATVTLAESHIAIHTWPEYGYFAADLFFCGQGQPKEAMKVLQTALEAKQATMREIDRGFPEVFASQNTTNMFEELVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V6</accession>
    <name>K9Z1V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0426"/>
    <dbReference type="EnsemblBacteria" id="AFZ52570">
        <property type="protein sequence ID" value="AFZ52570"/>
        <property type="gene ID" value="Cyan10605_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0426"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.449"/>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_2_3"/>
    <dbReference type="OMA" id="LWDGIRN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16653" checksum="22E8215136222E8C" modified="2013-03-06" version="1">MKSEPNVYSIDDLEREKRTIWDGVRNYQARNYLQQMQVGDIAFFYHSNCKSPSIVGLMMIIEANLPDPTQFDPKSSYFDPKATVEHPRWFTVRVQYQEKFSQVISLTTLKTKFSGDELLIVRKGNRLSVIPVAEEIAHKIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z220</accession>
    <name>K9Z220_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ordered locus">Cyan10605_0290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218170.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0290"/>
    <dbReference type="EnsemblBacteria" id="AFZ52438">
        <property type="protein sequence ID" value="AFZ52438"/>
        <property type="gene ID" value="Cyan10605_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0290"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.300"/>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
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                <person name="Eisen J.A."/>
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            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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            <strain evidence="3">PCC 10605</strain>
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            <dbReference type="EMBL" id="AFZ52725.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="768" mass="86983" checksum="9BC8B51E42632F30" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E7</accession>
    <name>K9Z2E7_CYAAP</name>
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        <submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
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                <person name="Goodwin L."/>
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                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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    <dbReference type="STRING" id="755178.Cyan10605_1200"/>
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        <property type="protein sequence ID" value="AFZ53319"/>
        <property type="gene ID" value="Cyan10605_1200"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_1_3"/>
    <dbReference type="OMA" id="YPDEEAQ"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="13007" checksum="100BC19D4CDCBB01" modified="2013-03-06" version="1">MAIKNIQKSKVNAILEIFKEKIVTIYQDELIQLILFGSRARGDAKQDSDIDILIVLKNFNQDKHKYEKMINLVSDLCLEYDLLISCVYVNESQFKSEKSPLMINIHKEGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P3</accession>
    <name>K9Z2P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218728.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0866"/>
    <dbReference type="EnsemblBacteria" id="AFZ52997">
        <property type="protein sequence ID" value="AFZ52997"/>
        <property type="gene ID" value="Cyan10605_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0866"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.909"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_4_3"/>
    <dbReference type="OMA" id="SGSIMQY"/>
    <dbReference type="OrthoDB" id="1560019at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="26435" checksum="67FBA022792D1DEF" modified="2013-03-06" version="1">MIELYYWATPNGHKITIFLEEAHLDYKIIPVNIAKGEQFNPDFLKISPNNRIPAIIDTEPTDKKESISIFESGAILLYLAQKTGKFLSSDIRQYAKTLEWLFWQVGGLGPMAGQNHHFGLYAPEKIPYAVDRYVKETNRLYGVLNKQLEGKDYIVGDYSIADMACYPWIVPYANQQQDITEFPHLEAWFKRMGEREGVIRAYKIAEQFKQPTVTEDSRSILFGQTASTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P6</accession>
    <name>K9Z2P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1362"/>
    <dbReference type="EnsemblBacteria" id="AFZ53476">
        <property type="protein sequence ID" value="AFZ53476"/>
        <property type="gene ID" value="Cyan10605_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1362"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1437"/>
    <dbReference type="eggNOG" id="ENOG502ZC76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089598_0_0_3"/>
    <dbReference type="OMA" id="IQINIGQ"/>
    <dbReference type="OrthoDB" id="1708551at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="238" mass="26945" checksum="A0D912D673EF266F" modified="2013-03-06" version="1">MVKHKSEIISHILTPAIKLWVRSQLQEIETLNIEIHAGDRQILRGKIEQVFLSAEKANYQGICINHAQVKTEEIAVNLGGILRGKPLKLLHPIFAEGEINLKKKDIQKSLASKLLSQGLIDLLALLLDYKGIKNPESILEKYSFYWQNVTLYTEKVIIEGQIKNQKEELSNINITTGLTLKNDHTLLFNPIEINSILFPEMVIIKEFEVDLGNDVAITDLILNEEELSCQGKIKIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S7</accession>
    <name>K9Z2S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tocopherol O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219240.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1399"/>
    <dbReference type="EnsemblBacteria" id="AFZ53511">
        <property type="protein sequence ID" value="AFZ53511"/>
        <property type="gene ID" value="Cyan10605_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1399"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1478"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_0_1_3"/>
    <dbReference type="OMA" id="LLDQWSH"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050342">
        <property type="term" value="F:tocopherol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="MTs_g-TMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="96"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="1">
        <location>
            <begin position="155"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="328" mass="36726" checksum="008966E76B6EA050" modified="2013-03-06" version="1">MFLYYALGVLLISVIIGVVIYLLTPRTFETPETVATSYDEWTEDGILEFYWGEHIHLGHYGSPPRRKDFLEAKADFVHEMVKWGGLDKLPRGTKVLDVGCGIGGSTRILAKDYGFEATGITISPKQVQRATELTPEGVSAKFQVDNALDLSFPDNSFDVVWSIEAGPHMPDKNKYAQEMMRVLKPGGTLVVADWNQRDDRKVPLNWWERIVMRQLLDQWSHPSFSSIEGFSEQIAETGLVDGDVVTADWTQETLPSWLESVWQGIVRPEGIIKFGLSGFIKSLREVPTMILMRVGFGSGLCRFGMFKAVKAKSATSTKEANTNEVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W0</accession>
    <name>K9Z2W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1381"/>
    <dbReference type="EnsemblBacteria" id="AFZ53494">
        <property type="protein sequence ID" value="AFZ53494"/>
        <property type="gene ID" value="Cyan10605_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1381"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471537_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="578" mass="66727" checksum="A53961A3971D38AD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z6</accession>
    <name>K9Z2Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218828.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0967"/>
    <dbReference type="EnsemblBacteria" id="AFZ53097">
        <property type="protein sequence ID" value="AFZ53097"/>
        <property type="gene ID" value="Cyan10605_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0967"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1021"/>
    <dbReference type="eggNOG" id="ENOG5032RN6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141457_0_0_3"/>
    <dbReference type="OMA" id="NRVSEFF"/>
    <dbReference type="OrthoDB" id="1812225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12723" checksum="263DDAE549AEAA6F" modified="2013-03-06" version="1">MNYQSNGNKFFQTGEGDNNFLEYIQSLTPETIAQLSKPQSSEVFQVMERNIVGMLGSLPPEHFGVMVSTSRENLGRLLASAMMSGYFLRNAEQRMNFEKAFMAGESHDEQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z305</accession>
    <name>K9Z305_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219320.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1480"/>
    <dbReference type="EnsemblBacteria" id="AFZ53591">
        <property type="protein sequence ID" value="AFZ53591"/>
        <property type="gene ID" value="Cyan10605_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1480"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1572"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_0_3"/>
    <dbReference type="OMA" id="VINRRDM"/>
    <dbReference type="OrthoDB" id="1083771at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="31998" checksum="0C907189063E39BD" modified="2013-03-06" version="1">MAIIQWYPGHISKAERQLKEQLKRVDVVLEVRDARIPLASHHPQLKQWIGDKPRLLVLNREDMISDSLRKEWQEWFGAQGEIPFFTNAKDGKGVKAVKKASQSMEKQVNERRRSRGMLPRPVRAVVIGFPNVGKSALINRLLQRKIVASARKAGVTKQLQWVRISDQLELLDAPGVIPWKLENQEDALKLAICEDIGEAAYDNQLVAADFVDLLVKLGSDEVLKSRYGLDPLEMTGEEFIYELAARKYKNDKERVARQLLQDFRKGYLGSVSLEYPPVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z330</accession>
    <name>K9Z330_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219293.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1453"/>
    <dbReference type="EnsemblBacteria" id="AFZ53564">
        <property type="protein sequence ID" value="AFZ53564"/>
        <property type="gene ID" value="Cyan10605_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1453"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1541"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_3"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="247"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="41673" checksum="AFC01563E48CBA25" modified="2013-03-06" version="1">MIPLQQQRAWVNINHHNLTHNVKVLKQWLNSGTKLMTVIKADAYGHGAVKVAQTVIKAGVDAVAIATLLEGIELRQAGIEAPILILGAINTADEVKEIVKHNLEATLCSPHQAQVFADTLQSLNYVLPVHLKLDTGMSRLGTHWHNAVDFVKYVQQFPQLQLKSVYSHLATADEEDTTVMKLQQSRFEEAIFALKSANISIPCLHLANSAGTLCDRSLHYDLVRVGLALYGLYPAPHLRHTVPLKPVLEVKARITQIKTIPAHTGVSYGHTFRCDRPLKIAVVGIGYADGIPRLLSNKMNVIVQGKLAPQIGNITMDQLMIDVTAFPDLEVGEIVTLLGEEGEIVISADDWANAIGTISWEILCSFKHRLPRINLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z386</accession>
    <name>K9Z386_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">Cyan10605_1509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1509"/>
    <dbReference type="EnsemblBacteria" id="AFZ53619">
        <property type="protein sequence ID" value="AFZ53619"/>
        <property type="gene ID" value="Cyan10605_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1509"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1602"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_7_1_3"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="23998" checksum="E7B72D0A160001E0" modified="2013-03-06" version="1">MIPDNICQCSTGFVMTFSLLISFGLILFAYLLGSIPTGYLVALVLKGIDIREYGSGSTGATNVLRTVGKGAALTVLLIDMLKGILAVASVKLFFIYGGGEILPIQWQDWLIAIASLLAVLGHSKSIWLKFSGGKSAAISLGILLTMNPFLGLGTLGVFVIVLSISKIVSLSSISAAIAVNILMWLLQPTAPYIVFAIIAASYVIIRHRSNIDRILSGKEPRIGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D4</accession>
    <name>K9Z3D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218836.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0975"/>
    <dbReference type="EnsemblBacteria" id="AFZ53105">
        <property type="protein sequence ID" value="AFZ53105"/>
        <property type="gene ID" value="Cyan10605_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0975"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1029"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_6_0_3"/>
    <dbReference type="OMA" id="IGVGINW"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="31011" checksum="9F2F8BABC84A8042" modified="2013-03-06" version="1">MNKIVFNLPETFAYNLFKLNQIDCYLYDTLTSTNDQAWLLEKQNNIPFPFVVIARQQTAGKGQRGHIWRSHLGGLYLSLGLELNLPVNCLHHLTLFSASAIASEFNNIKIPVAIKWLNDLILEGRKLGGILWETKIEKSIIKKAVIGIGINYQNNSPANGISLNDYLCVGQNPDIDSIEKIGFLAIKAIINGYYFYKNYGIDFVVKTYNSLLYNHKETALINQQKGEILGVNKNANLLIKISSQNAKTIIKFPPEKYSISYNKNSQGYFVLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E1</accession>
    <name>K9Z3E1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218841.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0980"/>
    <dbReference type="EnsemblBacteria" id="AFZ53110">
        <property type="protein sequence ID" value="AFZ53110"/>
        <property type="gene ID" value="Cyan10605_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0980"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1035"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055594_1_0_3"/>
    <dbReference type="OMA" id="AKRQCGR"/>
    <dbReference type="OrthoDB" id="1887294at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="37023" checksum="0319DDC1D719F294" modified="2013-03-06" version="1">MSPRKLSDGDRQEILSLYRNTNETTSTLAVRFGVSSSTVSRFLKNSLTETEYEDLIQEKRLARTAKNPEEEMEEKIIDHSSKDSKENDNDIDEYSSVIKEDQEKAQLNLDFEEENENLSLSSETQELEPISLHQDNTSVIPKIQLKEEDTRANNVMLDVQPEETEINEEEEEVLESVQVLAAMYGEDMEDEIEDIEEDEEDFEDEEIEKKLIVSNPMAESQLQVLPLENATFPKVCYLVIDRYAELVTKPLKDFGHLGKIPGSEILQLTLPIFDNHKVAKRFCDRKGKVIKVPDGKMLQKTSIYLKAKGISRILIDGKIYSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E6</accession>
    <name>K9Z3E6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219433.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1598"/>
    <dbReference type="EnsemblBacteria" id="AFZ53706">
        <property type="protein sequence ID" value="AFZ53706"/>
        <property type="gene ID" value="Cyan10605_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1598"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148731_0_0_3"/>
    <dbReference type="OMA" id="GLEWELF"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="11743" checksum="C3E597B7FB144BDC" modified="2013-03-06" version="1">MKKIHIALSTHNLKESIEEYSKRLSASPIIIIENEYALWKTETVNFSVRQDKSVKQGSLRHLGWEDSEATTFSQEIDVNGIVWENFNEQNQLQEIENLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I2</accession>
    <name>K9Z3I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1024"/>
    <dbReference type="EnsemblBacteria" id="AFZ53150">
        <property type="protein sequence ID" value="AFZ53150"/>
        <property type="gene ID" value="Cyan10605_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1024"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138407_0_0_3"/>
    <dbReference type="OMA" id="DHRENNP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15736" checksum="E7517C518B4AA8E8" modified="2013-03-06" version="1">MPSRIKIEPHLSLQELEQGYRKAKQGIEKIHYQVIWLLAQGKRTSYVSHVTGYSLSWIYELVRSYNRSGAKMLGDQRQHNRGRKPLLDDQQLALLYQRLQSPPDDQGLWNGVKVAKWLTQLLDRTIFSSKRMGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K9</accession>
    <name>K9Z3K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1208"/>
    <dbReference type="EnsemblBacteria" id="AFZ53327">
        <property type="protein sequence ID" value="AFZ53327"/>
        <property type="gene ID" value="Cyan10605_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1208"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1275"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001721_3_1_3"/>
    <dbReference type="OMA" id="GCYQAND"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="283"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="471"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="676" mass="79807" checksum="B47864ED2DF0CB21" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M3</accession>
    <name>K9Z3M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219528.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1698"/>
    <dbReference type="EnsemblBacteria" id="AFZ53801">
        <property type="protein sequence ID" value="AFZ53801"/>
        <property type="gene ID" value="Cyan10605_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1698"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1804"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_103_0_3"/>
    <dbReference type="OMA" id="HGKICRD"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="88" mass="9912" checksum="90858B16D365E3E1" modified="2013-03-06" version="1">MTTGNTSEFPILSERELEILELVATGLTNHDIADKLEISKRTVDNHISNILSKTKTDNRVELVRWALQWGKICLDEVNCCTLPSVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q1</accession>
    <name>K9Z3Q1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219558.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1728"/>
    <dbReference type="EnsemblBacteria" id="AFZ53831">
        <property type="protein sequence ID" value="AFZ53831"/>
        <property type="gene ID" value="Cyan10605_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1728"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1835"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_0_3"/>
    <dbReference type="OMA" id="KLNRGPN"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="457" mass="50886" checksum="1C2346CED413E4B8" modified="2013-03-06" version="1" precursor="true">MEKKPRHRKKVNHLFKWLSPGIFVKRWLLTSIIGAFMIALGLAIWSNLTPVFRIFEFIFNTLDQITNYIPSHISGPLVLFLGLFLLLWGQTRTLGSITEVLKPDKDEELIDVLWHYRRLNKGTKIVAIGGGTGLSTLLRGLKEYSANITAIVTVADDGGSSGRLRREMGILPPGDIRNCMAALADEEKLLTELFQYRFTAGEGLNGHSFGNLFLTAMTNITGDLEGAIAKSSKVLAIQGKVLPATLEDVTLWARLEDGRVIYGESNIPDAGGKIVELGCNPTNPPATPAVVKAIQQAEYIILGPGSLYTSIIPNLLVPEIREAILNSSAPKIYVCNIMTQKGETDGYTVSDHIKAIDKVCGKKIFDAVLVQGRQPSPEALRKYAEKHCHPVYLDREEVEKLGRRIVKANVMSENRDSAYVRHDPQLLGKVLFRWYSNMPKSKFVKNSKQFLMDISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R5</accession>
    <name>K9Z3R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1669"/>
    <dbReference type="EnsemblBacteria" id="AFZ53774">
        <property type="protein sequence ID" value="AFZ53774"/>
        <property type="gene ID" value="Cyan10605_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1669"/>
    <dbReference type="HOGENOM" id="CLU_208303_0_0_3"/>
    <dbReference type="OMA" id="TTHFITA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="56" mass="6384" checksum="0269581A67B12D9C" modified="2013-03-06" version="1">MTTHFISTEIALPANPLILKQEIEQTLNQQGKPLRWAITSVNEIEKKVKVEAIITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S4</accession>
    <name>K9Z3S4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219126.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1282"/>
    <dbReference type="EnsemblBacteria" id="AFZ53397">
        <property type="protein sequence ID" value="AFZ53397"/>
        <property type="gene ID" value="Cyan10605_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1282"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1354"/>
    <dbReference type="eggNOG" id="COG4370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035659_0_0_3"/>
    <dbReference type="OMA" id="SGGFIYM"/>
    <dbReference type="OrthoDB" id="368220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019994">
        <property type="entry name" value="CHP03492"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39517">
        <property type="entry name" value="PTHR39517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03492">
        <property type="entry name" value="TIGR03492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="431" mass="48291" checksum="C34254933C46FB43" modified="2013-03-06" version="1">MNRRLLVISNGHGEDVIAVKIIQELWKLQKINFSSDSNQEYCPINITALPMVGEGFAYQKIDIPLLGKVQKMPSGGFIYMDGRQLWKDIKSGLVGLTLHQYQQVKQWSREGGLILAVGDILPLLWANLSGVNYFFVGTAKSEYYLRNEEGWLEDVSIVDRFLGSIYYPWERWLMSSKSCLGIFPRDSLTVESLQNYGIRAYDYGNPMMDDVDISFSPVQNPDDEYTLKVLLLPGSRLPEALDNWQLILSAVDSLLEIQDLDLRFVGAIASSLNLNVFAEIAQKFQWKPIQKKSVNIPIEDPDKMILTKNKAQLILSQNSYAQSLQYCDISIAMAGTATEQFVGLGKPAIAFAGTGAQYNPKFAKNQSRLLGISLQLVENPQQVKDKVQELLSNPDLWQSISVNGKKRLGSAGGAKKIARELLSKLTQRSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W6</accession>
    <name>K9Z3W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218989.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1138"/>
    <dbReference type="EnsemblBacteria" id="AFZ53260">
        <property type="protein sequence ID" value="AFZ53260"/>
        <property type="gene ID" value="Cyan10605_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1138"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135680_0_0_3"/>
    <dbReference type="OMA" id="EWLYEQM"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="19147" checksum="3BD052B3680CF34F" modified="2013-03-06" version="1">METIYIPQLLKMPEQTMEIKLCDRISGLTTLTPVKGIFQVRHGGNFLDLQLQADTILTLTCDRCLQTFNYRLEVDTSEIIYLKYEAELNQYYPPEREITGEDLWESLPPDGELIIEEWIYQQLSLAIPLRSLCSNDCQPPGKTSTDNNKNDKRWSALANLKSLMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X4</accession>
    <name>K9Z3X4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219628.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1799"/>
    <dbReference type="EnsemblBacteria" id="AFZ53901">
        <property type="protein sequence ID" value="AFZ53901"/>
        <property type="gene ID" value="Cyan10605_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1799"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1908"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_3"/>
    <dbReference type="OMA" id="LHQRERF"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="276" mass="30124" checksum="F4711361280B6C1E" modified="2013-03-06" version="1">MTVAQSSSISQFWQETFALNKRLFIQLKRRPSTLVAGVIQPFMWLILFGALFRGAPQGLFGNDLNYAQFLAPGIIVFTAFSGALNAGLPVMFDREFGFLNRLLVAPLTSRFSIVMASVIYIITLSLIQTAVIVIASAFIGAGLPSFAGLSAIALIVFLIVLGVTGLSLGFAFALPGHIELIAVIFVINLPLLFASTALAPLSFMAKWLQIVASLNPLTYAIEPIRYIYQNSDWSLSSVVMNTPWVDFSLVTVLSILLTFDLVILLTIKPLLSRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X5</accession>
    <name>K9Z3X5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219561.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1731"/>
    <dbReference type="EnsemblBacteria" id="AFZ53834">
        <property type="protein sequence ID" value="AFZ53834"/>
        <property type="gene ID" value="Cyan10605_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1731"/>
    <dbReference type="eggNOG" id="ENOG5032SHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166142_1_0_3"/>
    <dbReference type="OMA" id="IFLWRWE"/>
    <dbReference type="OrthoDB" id="1951831at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021883">
        <property type="entry name" value="LPA1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11998">
        <property type="entry name" value="DUF3493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10245" checksum="1A51FAFEFD0F94EF" modified="2013-03-06" version="1">MNNNSDNQKNNKLSSEKYAYLKAEAQAPYKGLRKFIYLGLGASGAIGAFIFFAQLLAGKNVSDNIYNLFVQITVIAIMVFLYRWEDRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z431</accession>
    <name>K9Z431_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219231.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1389"/>
    <dbReference type="EnsemblBacteria" id="AFZ53502">
        <property type="protein sequence ID" value="AFZ53502"/>
        <property type="gene ID" value="Cyan10605_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1389"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896350_0_0_3"/>
    <dbReference type="OrthoDB" id="2147998at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="36412" checksum="A392AAB3FC3DD77C" modified="2013-03-06" version="1">MLINEKLISSLEYISEVRKNLPEELSKMTEILNDIRENLNNVIEKNNNKQEEVVRQLIEVQKKLSNFPQIIITQQGLLQIKMVAVSNKIKQLNETMINQQKELNSPMQTLNGYFDKFEQQLEKMKTHHLQILGEGITIFNELWESLQANHESIEITWQSTQQEIEILSEKVNYLEEVIEYNLENFTNQINDYQEDINSNLEDNLKPKLANYSTDLEELLEQSINNIEQKISSFRENSEENIEKARFLFKDKINNFREELTTLIESDSALEKLKDHDSLFTDNSKEIEIFIEKLKKLITDIEEVGESLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z454</accession>
    <name>K9Z454_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamentous hemagglutinin family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219701.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1876"/>
    <dbReference type="EnsemblBacteria" id="AFZ53976">
        <property type="protein sequence ID" value="AFZ53976"/>
        <property type="gene ID" value="Cyan10605_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1876"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1991"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239210_0_0_3"/>
    <dbReference type="OMA" id="RIRANNI"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05860">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01901">
        <property type="entry name" value="adhes_NPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Haemagg_act" evidence="2">
        <location>
            <begin position="53"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1626" mass="176503" checksum="2B90E89D9DACFE2C" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z469</accession>
    <name>K9Z469_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219104.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1259"/>
    <dbReference type="EnsemblBacteria" id="AFZ53375">
        <property type="protein sequence ID" value="AFZ53375"/>
        <property type="gene ID" value="Cyan10605_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1259"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1330"/>
    <dbReference type="eggNOG" id="ENOG5032YG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167648_0_0_3"/>
    <dbReference type="OMA" id="VQHYLPS"/>
    <dbReference type="OrthoDB" id="1854191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="11355" checksum="3454053D1979ECD9" modified="2013-03-06" version="1">MKKSLSHSIKKIYRKEPISAFIIIFGFVDSILGGFEERWTLLSLGLLIATTGLFMRWLQTTKPQKITTVSRTRRYLPPSRNSLTPLPPLKRKRDYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z489</accession>
    <name>K9Z489_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1858"/>
    <dbReference type="EnsemblBacteria" id="AFZ53959">
        <property type="protein sequence ID" value="AFZ53959"/>
        <property type="gene ID" value="Cyan10605_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1858"/>
    <dbReference type="HOGENOM" id="CLU_2536958_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9746" checksum="8A292C545DF8CCAE" modified="2013-03-06" version="1" precursor="true">MKQIFNLFYMITFIYSISFSAYLGWWILRDWKALEYSHNVEKNYDVSIHHRINLVAEGTGFLLLNCLTAMSVIGLNINNRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C8</accession>
    <name>K9Z4C8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Light-independent protochlorophyllide reductase subunit B</fullName>
            <shortName evidence="11">DPOR subunit B</shortName>
            <shortName evidence="11">LI-POR subunit B</shortName>
            <ecNumber evidence="11">1.3.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">chlB</name>
        <name evidence="14" type="ordered locus">Cyan10605_1486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:28202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10002"/>
            <dbReference type="Rhea" id="RHEA-COMP:10004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83348"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.3.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; bacteriochlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Protochlorophyllide reductase is composed of three subunits; ChlL, ChlN and ChlB. Forms a heterotetramer of two ChlB and two ChlN subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ChlB/BchB/BchZ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219326.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1486"/>
    <dbReference type="EnsemblBacteria" id="AFZ53597">
        <property type="protein sequence ID" value="AFZ53597"/>
        <property type="gene ID" value="Cyan10605_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1486"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1578"/>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025470_0_0_3"/>
    <dbReference type="OMA" id="TTFQARD"/>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="UniPathway" id="UPA00669"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016636">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030494">
        <property type="term" value="P:bacteriochlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036068">
        <property type="term" value="P:light-independent chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019685">
        <property type="term" value="P:photosynthesis, dark reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00353">
        <property type="entry name" value="ChlB_BchB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005969">
        <property type="entry name" value="Protochl_reductB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016209">
        <property type="entry name" value="Protochlorophyllide_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000163">
        <property type="entry name" value="PCP_ChlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01278">
        <property type="entry name" value="DPOR_BchB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="12">
        <location>
            <begin position="12"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PCP_red" evidence="13">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="429"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="57318" checksum="992BDC4AE2AD9145" modified="2013-03-06" version="1">MKLAYWMYAGPAHIGTLRIASSFKNVHAIMHAPLGDDYFNVMRSMLERERDFTPVTASVVDRNVLARGSQEKVVDNIVRKDKEEKPDLIVLTPTCTSSILQEDLENFVQRAQLNSNSDVLLADVNHYRVNELQAGDRTLEQIIQFYLQKAQKKGDVVTEKTPHPSVNIIGISTLGFHNNHDCTELQRLMRDLGIEVNLILPDSASVHDLKKIPSAWFNLVPYRELGLMSARYLEEEWGMPYVDITPMGVVETARCVRKIQQILNGLGANVDYEEFIEHQTLYVSQAAWFSRSIDCQNLTGKKAVVFGDNTHAVAMTKILAREMGIHVVLAGTYCKYDGDWFTQQVSEYCDRVLISDDNGEIADAIAKIEPAAIFGTQMERHVGKRLNIPCGVISAPIHIQNFPIGYKPFMGYEGTNQIADLVYNSFTLGMEDHLLEIFGGHDTKEVITKGISADSDLNWDTEAQKELNKVPGFVRGKVKRNTEKFARDRGFEKITLEVLYAAKEAVSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G1</accession>
    <name>K9Z4G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1361"/>
    <dbReference type="EnsemblBacteria" id="AFZ53475">
        <property type="protein sequence ID" value="AFZ53475"/>
        <property type="gene ID" value="Cyan10605_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1361"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1436"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_3"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="27939" checksum="8A0BE9FB3C107041" modified="2013-03-06" version="1">MERVQKILREWGIASRREGEKMILEGRVKVNGITVKLGDLASAQRDKIEVDGKLLTSQRKPSLIYLLLNKPKGYICTCDDPRQRKTVMDLLPAELRIGCGIHPVGRLDRNSSGALILTNDGALTVHLTHPRYNHPKTYSVTLRGKIPHRFIKKWAEGFMWEGKKTLPAEININYQDEQKTQMQITLREGRNRQIRKIAELFGYPVISLHRSAIAFLNVSSLSTGEYRYLTTKEVNYLKELHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I4</accession>
    <name>K9Z4I4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219022.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1172"/>
    <dbReference type="EnsemblBacteria" id="AFZ53293">
        <property type="protein sequence ID" value="AFZ53293"/>
        <property type="gene ID" value="Cyan10605_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1172"/>
    <dbReference type="eggNOG" id="ENOG503376Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683652_0_0_3"/>
    <dbReference type="OMA" id="YYVAAWI"/>
    <dbReference type="OrthoDB" id="2043615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="18705" checksum="3DF378E38BC7F4B7" modified="2013-03-06" version="1">MKVGEIIRIIVFALVGFFVMMWLQPFLYEQRFFGVIKSIPIRDWIQQYYVAAWIVFGFSVLFTVLWYIILLKNQGGSADSFKLLWVVGAGLLVLVVSLAVYFNNQDENGELIQETMFSMIGLFLFDSLFLLYWLPTVTSTPGLLKRKTVPFAIPVNDLMNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L5</accession>
    <name>K9Z4L5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219254.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1413"/>
    <dbReference type="EnsemblBacteria" id="AFZ53525">
        <property type="protein sequence ID" value="AFZ53525"/>
        <property type="gene ID" value="Cyan10605_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1413"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1494"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_3"/>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="82"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="350"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="652" mass="71216" checksum="35CCC4C7369605FD" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y8</accession>
    <name>K9Z4Y8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrate ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219207.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1364"/>
    <dbReference type="EnsemblBacteria" id="AFZ53478">
        <property type="protein sequence ID" value="AFZ53478"/>
        <property type="gene ID" value="Cyan10605_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1364"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1439"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_1_3"/>
    <dbReference type="OMA" id="CSIWPMI"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005889">
        <property type="entry name" value="NtrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01183">
        <property type="entry name" value="ntrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="29921" checksum="F5BC35D8B3EF9EF2" modified="2013-03-06" version="1">MANSSINLRLRKKNPLSFLYSKKVIRPAVAIIVFLVIWQIVCTGQNSNLPSPVQVFEDTYPLIIDPFFDNGGTDKGLAIQIFASLTRVAIGFSLATIVGIGLGILIGANKIIYDAVDPIFQVLRTIPPLAWLPIALAAFQEAEPSAIFVIFITAIWPIIINTTVGVQKIPQDYTNVSRVLKLSKTEYFFNILFPASVPYIFTGLRIGIGLSWLAIVAAEMLIGGVGIGFFIWDAYNSSLMSEIIIALIYVGIVGLLLDRFVGFIASIVVPGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z500</accession>
    <name>K9Z500_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="4" type="ordered locus">Cyan10605_1714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219544.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1714"/>
    <dbReference type="EnsemblBacteria" id="AFZ53817">
        <property type="protein sequence ID" value="AFZ53817"/>
        <property type="gene ID" value="Cyan10605_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1714"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1821"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134083_1_1_3"/>
    <dbReference type="OMA" id="HQNEMAL"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="10597" checksum="100EED2C28CCCA9B" modified="2013-03-06" version="1">MATQVIQNPQTKANSEKKHHPGYRVLLHNDSFNTMEYVVETLMETVGMSEPQAVSVMMEAHTNGVGLVTVCALEHAEFYCESLKSKGLTSTIEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z538</accession>
    <name>K9Z538_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219257.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1416"/>
    <dbReference type="EnsemblBacteria" id="AFZ53528">
        <property type="protein sequence ID" value="AFZ53528"/>
        <property type="gene ID" value="Cyan10605_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1416"/>
    <dbReference type="eggNOG" id="ENOG50316C6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1977470_0_0_3"/>
    <dbReference type="OMA" id="IDGFHEW"/>
    <dbReference type="OrthoDB" id="1816820at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="15349" checksum="14E61388FBFB5B58" modified="2013-03-06" version="1">MWGKFQQSELRIEVSADEKKLKDSLLNIEQLEKWFFPLKFQDKRPNQLESGDKFIIKLGLVEVRNEVEIINSNCIRFLLSGGIDGYQEWCWGDEWIQSRLEGVSILPLNFAQTMNLLRLRTFVGAEIGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A4</accession>
    <name>K9Z5A4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219649.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1820"/>
    <dbReference type="EnsemblBacteria" id="AFZ53922">
        <property type="protein sequence ID" value="AFZ53922"/>
        <property type="gene ID" value="Cyan10605_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1820"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1931"/>
    <dbReference type="eggNOG" id="COG3596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057498_0_0_3"/>
    <dbReference type="OMA" id="PFATMPV"/>
    <dbReference type="OrthoDB" id="546910at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="391" mass="42873" checksum="628BE66C95239E87" modified="2013-03-06" version="1">MKLPSVRDTAKKALNLFRVDEEEIKKILAEVRSQLPTTEALLIGKPQAGKSSIVRGLTGVGKEIVGQGFRPHTQHTERYAYPSEDLPLLIFTDTVGLGDINNSTEVIIEELTAELERESKKARILILTVKINDFATDSLKMVAENLQKKYPQIPCLLVVTSLHELYPNCDTNHPDYPPTFSEIDRAFIEIKNTFQGLFDQAVLIDFTLEEDEYNPVFYGLEALRDSLAELLPSAEAQTIHKLLDQTVDSQLGSIYRDVARRYILAFSIMAGTVAAVPLPFATMPVLTALEVTMVGVLGQLYGQKISASQAGGILSAIAGGFLAQAIGRELIKFVPGFGSVVAASWAGAYTWALGEGACVYFGDLMGGKKPDPNQIKEVMKDAFDNAKKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I5</accession>
    <name>K9Z5I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219727.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1904"/>
    <dbReference type="EnsemblBacteria" id="AFZ54002">
        <property type="protein sequence ID" value="AFZ54002"/>
        <property type="gene ID" value="Cyan10605_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1904"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2021"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_2_2_3"/>
    <dbReference type="OMA" id="FFNNKQT"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="21925" checksum="EE62BECB0B7B8A48" modified="2013-03-06" version="1">MGINLQKGQRISLKKEAPKLEQLMCGLGWDVAKKKGGFLSGLFTTDFDLDASVLCLNQDGKIKSNSEIVFFGNLRHYSDAINHMGDNLTGAGDGDDEQILVKLPLIPQNIHKLVFVVNIYNALERSQDFSQVENAFVRLVNLSNNQEIARYTLSGNGYQGKTGMIMAEIARVGDDWEMMAKGEGFQVKSLGDVMKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J2</accession>
    <name>K9Z5J2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif putative anchor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220138.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54414">
        <property type="protein sequence ID" value="AFZ54414"/>
        <property type="gene ID" value="Cyan10605_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2330"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2474"/>
    <dbReference type="eggNOG" id="ENOG5033111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094506_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026374">
        <property type="entry name" value="Cyano_PEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025193">
        <property type="entry name" value="DUF4114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13448">
        <property type="entry name" value="DUF4114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04155">
        <property type="entry name" value="cyano_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938626" evidence="1">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4114" evidence="2">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="26396" checksum="F3D257246CC5DFEB" modified="2013-03-06" version="1" precursor="true">MNKFLSLSFTPLAVTATVASIALSSGSAQAVTIGPPAAGEQSLQTILDNISSPGAITVQSDAEFFKPNSSNSATSSIVIEFAGNAANNVLGIYNSIGGTMVDIFGGGATQGSKVFLNFSGGNLGLFDINNNAIGNGTFNGFGTNFGFYLRGVNQQVLYSQSAANPNGFDAMAAFSGADNQTTLTLPPNNSSGTFDGGDWIFAWEDSYLGDGDYNDFVVHVSDIEAVPEPLTILGTGLALGLGGLFKSKQSKKQSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P0</accession>
    <name>K9Z5P0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Photosystem II protein D1</fullName>
            <shortName evidence="16">PSII D1 protein</shortName>
            <ecNumber evidence="16">1.10.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Photosystem II Q(B) protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">psbA</name>
        <name evidence="19" type="ordered locus">Cyan10605_0832</name>
        <name evidence="20" type="ordered locus">Cyan10605_2424</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2</text>
            <dbReference type="Rhea" id="RHEA:36359"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.10.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="16">The D1/D2 heterodimer binds P680, chlorophylls that are the primary electron donor of PSII, and subsequent electron acceptors. It shares a non-heme iron and each subunit binds pheophytin, quinone, additional chlorophylls, carotenoids and lipids. D1 provides most of the ligands for the Mn4-Ca-O5 cluster of the oxygen-evolving complex (OEC). There is also a Cl(-1) ion associated with D1 and D2, which is required for oxygen evolution. The PSII complex binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cellular thylakoid membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="16">C-terminally processed by CtpA; processing is essential to allow assembly of the oxygen-evolving complex and thus photosynthetic growth.</text>
    </comment>
    <comment type="PTM">
        <text evidence="16">Tyr-161 forms a radical intermediate that is referred to as redox-active TyrZ, YZ or Y-Z.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Cyanobacteria usually contain more than 2 copies of the psbA gene.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Herbicides such as atrazine, BNT, diuron or ioxynil bind in the Q(B) binding site and block subsequent electron transfer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16 17">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.9" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218695.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0832"/>
    <dbReference type="EnsemblBacteria" id="AFZ52964">
        <property type="protein sequence ID" value="AFZ52964"/>
        <property type="gene ID" value="Cyan10605_0832"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54506">
        <property type="protein sequence ID" value="AFZ54506"/>
        <property type="gene ID" value="Cyan10605_2424"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0832"/>
    <dbReference type="KEGG" id="can:Cyan10605_2424"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2568"/>
    <dbReference type="eggNOG" id="ENOG502Z87P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054206_1_0_3"/>
    <dbReference type="OMA" id="CQWVTDT"/>
    <dbReference type="OrthoDB" id="382342at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010242">
        <property type="term" value="F:oxygen evolving activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009635">
        <property type="term" value="P:response to herbicide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09289">
        <property type="entry name" value="Photosystem-II_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01379">
        <property type="entry name" value="PSII_PsbA_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036854">
        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005867">
        <property type="entry name" value="PSII_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PTHR33149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00256">
        <property type="entry name" value="REACTNCENTRE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="SSF81483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01151">
        <property type="entry name" value="psbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="13 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 16" id="KW-0359">Herbicide resistance</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 16" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="16" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_5035011685" description="Photosystem II protein D1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5035011686" evidence="16">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Quinone (B)" evidence="16">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>ChlzD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[CaMn4O5] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:189552"/>
        </ligand>
        <ligandPart>
            <name>Mn</name>
            <dbReference type="ChEBI" id="CHEBI:18291"/>
            <label>1</label>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>PD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>[CaMn4O5] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:189552"/>
        </ligand>
        <ligandPart>
            <name>Mn</name>
            <dbReference type="ChEBI" id="CHEBI:18291"/>
            <label>1</label>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="site" description="Tyrosine radical intermediate" evidence="16">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes free radical intermediate" evidence="16">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by CtpA" evidence="16">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ52964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFZ54506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="356" mass="39373" checksum="DBF3D83E09DE7EDF" modified="2013-03-06" version="1">MTTTLQQQQQLSAWEQFCQWITSTNNRLYVGWFGVLMIPCLLTATTCFIIAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGVFCYMGRQWELSYRLGMRPWICVAYSAPVSAATAVFLIYPIGQGSFSDGMPLGISGTFNFMFVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLGAWPVIGIWFTAMGISTMAFNLNGFNFNQSILDSQGHVIGTWADVLNRANIGIEVMHERNAHNFPLDLASAEPVSAPVING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q3</accession>
    <name>K9Z5Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">Cyan10605_2440</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell inner membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220244.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2440"/>
    <dbReference type="EnsemblBacteria" id="AFZ54521">
        <property type="protein sequence ID" value="AFZ54521"/>
        <property type="gene ID" value="Cyan10605_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2440"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2585"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_3_1_3"/>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="OrthoDB" id="1996371at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFZ54521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="27806" checksum="6CD41411C9D5EF72" modified="2013-03-06" version="1">MKNFVSSFFGAVIFYSRIPLPSFISISFFKIALWLPWIGVLLASLLSVFALILDVIGFPPLTKIVLLVFAWICVTGGLHFDGAIDAGDAWGVQGDQKKRLEVMQDSRVGAYGLISGIFLVLLKIVSLYELSIPLWWGLMISMSWGRWGQLGAIALYPYVREEGKGAFLKKDLNFPLDGIIGSLFIIFLIIIQIYFLGNSLTQVITTNIIGASISLMMGWLIQKPLGGHTGDTYGATVEWSEALILCFLSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S3</accession>
    <name>K9Z5S3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220223.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2417"/>
    <dbReference type="EnsemblBacteria" id="AFZ54499">
        <property type="protein sequence ID" value="AFZ54499"/>
        <property type="gene ID" value="Cyan10605_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2417"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2561"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_3"/>
    <dbReference type="OMA" id="ESFSAWH"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="49322" checksum="258012FBE511FEE1" modified="2013-03-06" version="1">MNFLLFYPTQPKKFIQRILVLLCCFNLLFVTGCQNINNQQISDNTITKITFWHGINPPENREIFNELLTEFNDNNPDIQVEALYVGQPDEQLPKIIASIAANQPPDILWYVPQLTGKLVKLQALKPLQDWWNNSSIKEEIDPAMLPTMELNDSIWSVPFATNNTAMFYRPSLFEEAGITDTPKTWDEFQQVAEKLTIDSNNDGVNEQNGVLLAVGKGEFTVFVWLPFIFSANGEITADNRPNIINEGTEKTLQLAQKLVAKKVAILSAPDRGYELDNFINGKVAMQITGPWTLAQLNQTGIDYDVFPLPMINQPATVLGGENLFVFKTNQEREEASLKFLEFILSEKFQTQWALKTGYLPININAQNSPEYQQFVQANPVIKVFLEQMKYAKSRPIIAQYPSLSENLGRAIESVLLGEKTPENALQEAQKRLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U0</accession>
    <name>K9Z5U0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219667.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1838"/>
    <dbReference type="EnsemblBacteria" id="AFZ53940">
        <property type="protein sequence ID" value="AFZ53940"/>
        <property type="gene ID" value="Cyan10605_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1838"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1951"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029517_1_1_3"/>
    <dbReference type="OMA" id="NWGYTLY"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="35"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="387" mass="45481" checksum="E5091FC17A23944B" modified="2013-03-06" version="1" precursor="true">MKYLKLISLFLATVLIFYSWSKWSYSQPIVDNRGEIRGVWLTNIDSEILFSSQNTQNAIASLKELNFNSLYPTVWNWGYTLYPSQVAEKVIGSKIDPHEGLQNRDVLAEIITKAHQSNMRVIPWFEFGFMAPADSVLATSHPQWLTRRKDDSEIWMEGKTHERVWLNPLHPQVQEFITDLVVEIVTNYDIDGIQFDDHFGYPSEFGYDSYTTGLYRREHQGKLPPLDYLDPEWIEWRSHKITEYMETLFHKIKAIKQNVIVSVSPNPQEFSKEMFLLDWAKWERKGFIEELIVQIYRDNMEAFNRELVQKDLQLAKDHIPTAIGILTGLKGRPVNLDLIEAQINTTREQNFAGVSFFFYESLWNIASETPQERQEFWAKIFSDKEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W4</accession>
    <name>K9Z5W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2043"/>
    <dbReference type="EnsemblBacteria" id="AFZ54132">
        <property type="protein sequence ID" value="AFZ54132"/>
        <property type="gene ID" value="Cyan10605_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2043"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2170"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_3"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="410" mass="44817" checksum="0C239BE3C28260CC" modified="2013-03-06" version="1">MREIFFNVKTFIILWLGQLFSAVGSAMTYFTLTLWVWQKTESATAIALILVFYQLPQVIITPLTGILIDRTSRKQLLIISDTGSAFCTISVGILAFLGTLQVWHIYLIASVIGCFGNIQSLTYSTLIPLILPEKHHTRASSMGAMVVYGAGIISPALAGVLFPLIGLFGITLIDMGTFAIAFCFILMIHIPHTIKQDQEKVNHLSNLTFGFRYIYSHPELLSMVIMVSLFSFFNDISETLYQPMILAKTDSNSQILGIVVAGGGLGGVVGGLIVSVWGGFKKLRRGIFTGFLGTGISILILALASLPSFWIIARFAWSFHHPLMMSSYMAIWYAKIPHHLQGRVFGADYLIGILVTTCSSLTAGVLSDRIFEPLLQSQYSLPSGSGMAFLIAISATIIILVSSKVANILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y0</accession>
    <name>K9Z5Y0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219705.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1880"/>
    <dbReference type="EnsemblBacteria" id="AFZ53980">
        <property type="protein sequence ID" value="AFZ53980"/>
        <property type="gene ID" value="Cyan10605_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1880"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1995"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_0_3"/>
    <dbReference type="OMA" id="MHERIRF"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11757" checksum="ED557B5E0BE4C6A0" modified="2013-03-06" version="1">MIPNKNQINISHHAISQLCQKYHIKKLALFGSVLRDDFTSQSDIDILVEFIEGKTPGFRFIEIQDKLTQLLGRTVDLNTAQDLSCYFRDEVVNNAQVIYEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y1</accession>
    <name>K9Z5Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219872.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2058"/>
    <dbReference type="EnsemblBacteria" id="AFZ54147">
        <property type="protein sequence ID" value="AFZ54147"/>
        <property type="gene ID" value="Cyan10605_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2058"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_5_2_3"/>
    <dbReference type="OMA" id="RPNIPYT"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939122" evidence="7">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="82"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="276" mass="30678" checksum="9B806281C02C598E" modified="2013-03-06" version="1" precursor="true">MFKYYRKLVYLLTSIFVASSLIITDVQPSNAIPWQELIFRGIQLIQINNISDQQEREIGGQIRQQLISQGKVKLYRDENLSAYVNQIGRRLVAVSGRPNIPYRFEIVDNPQVNAFATMGGYIYLHTGLITAADNEAELASVIAHEIGHVVARHSQKQMQQQAVTQGLLSVAGLDRTQVVQLGVALAVDLPYSRQDEYEADTLGLEMLKGAGYAPQAMVDFMRKLAKTGGRTPTLLSTHPASGDRAIALEQKIPASRGYQGDGLDEQAYRYQIRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y2</accession>
    <name>K9Z5Y2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220319.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2515"/>
    <dbReference type="EnsemblBacteria" id="AFZ54596">
        <property type="protein sequence ID" value="AFZ54596"/>
        <property type="gene ID" value="Cyan10605_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2515"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="VWGWDFG"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26958" checksum="95EBC74464C77849" modified="2013-03-06" version="1">MEVVLAKILVVDDDIHITNLITRFLRQKQYLVEYANDGQKARDIFKHFHPDLVILDINLPDTLGYNLCAEMQENNDVFVLMLTSRTDVEDKKKGFSTGADDYLTKPFDLEELEFRIQAILRRRRIIKSVGGETLDFGDLVINPETREVKVKTQSITLTSLEFDLLYFLASNPNRVWSREDLVNNVWQSNPMGDNRVVDVHIGQIRRKIELDSEATRHISTVRGVGYKFEIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z621</accession>
    <name>K9Z621_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2556"/>
    <dbReference type="EnsemblBacteria" id="AFZ54636">
        <property type="protein sequence ID" value="AFZ54636"/>
        <property type="gene ID" value="Cyan10605_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2556"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2713"/>
    <dbReference type="eggNOG" id="ENOG502ZS06">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174539_0_0_3"/>
    <dbReference type="OrthoDB" id="2198833at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="13636" checksum="4EF3DC8DB6DC1D5A" modified="2013-03-06" version="1">MNKKNKKLITITHIPTSKIIARGFEGWGFMAFEGNYYIRLKYIRTTGFQFSYIPRFCIYKFLYVWLHLKVKDYKEEFIAWMYVIPNPLLPFIWFRIGLPRNHHALKIEIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z626</accession>
    <name>K9Z626_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219575.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1745"/>
    <dbReference type="EnsemblBacteria" id="AFZ53848">
        <property type="protein sequence ID" value="AFZ53848"/>
        <property type="gene ID" value="Cyan10605_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1745"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1852"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_3"/>
    <dbReference type="OMA" id="YPQDAQV"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="39450" checksum="7B6BB6F9B6F4C26E" modified="2013-03-06" version="1" precursor="true">MKKIIIVGSGIVGSAIAYELSNNSEFDITLIDEKNPGTGATGAALGILMAIISLKTKGRAWKLRELSLKRYKTLISELENFTGLSIPHNRQGIVKLLFTEEQLQRYAKLAQFRASQGYKLDIWDQSLLKFHCPEINTSSIVGAVYSPDDWQVSPTFLTKALVKGASMKGVKCIFGEKVKGLNIRSENHTEVILENQSLSADIVIIATGLGTSSLLESLHIPIEIKPVLGQALLVKYDQWQSKEDFNPVITGNDIHIAPMGNNEFWLGATVEFPDSKGEVIAKDQLLQNLRSDAIAFCPSLAQAPIMLSWTGKRPRPEGKSAPIIEKLEPYKNIILATGHYRNGVLLAPATALIIKEMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C4</accession>
    <name>K9Z6C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit sodium/proton antiporter, MrpE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220017.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2206"/>
    <dbReference type="EnsemblBacteria" id="AFZ54292">
        <property type="protein sequence ID" value="AFZ54292"/>
        <property type="gene ID" value="Cyan10605_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2206"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155299_0_0_3"/>
    <dbReference type="OMA" id="GWYEVHR"/>
    <dbReference type="OrthoDB" id="2067905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="15108" checksum="DB746E61318AAA82" modified="2013-03-06" version="1">MILHLIFRLGIWFLLTSDLSPANIMIGVAIAFILPKPRIGLADIKEWLKILAKMLIVFPQAYWEALEIMLFPHRYEGLNMEKVPAGRSPLLIFLDIFFITFTPKTVVVKYHKEGWYEVHRIDRKQLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E8</accession>
    <name>K9Z6E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XisH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220479.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2682"/>
    <dbReference type="EnsemblBacteria" id="AFZ54756">
        <property type="protein sequence ID" value="AFZ54756"/>
        <property type="gene ID" value="Cyan10605_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2682"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2847"/>
    <dbReference type="eggNOG" id="ENOG5030IHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132053_0_0_3"/>
    <dbReference type="OMA" id="YVIQYRR"/>
    <dbReference type="OrthoDB" id="1722526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014919">
        <property type="entry name" value="XisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08814">
        <property type="entry name" value="XisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16903" checksum="AEEEF883DE2D3FB4" modified="2013-03-06" version="1">MPAKDVYHDIVKNALIKDGWMILAAPYTIEYEDDNLYADLLAQKTLLAQQQDRKIVVEIKSFLNPSPMNDFQNALGQYLLYRDFLNFSHKNYELYLAVKSSVFNSFFQRKSIQAVIKHYGVDFIVFNQNREEIISWVKLSNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M4</accession>
    <name>K9Z6M4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ordered locus">Cyan10605_1958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1958"/>
    <dbReference type="EnsemblBacteria" id="AFZ54053">
        <property type="protein sequence ID" value="AFZ54053"/>
        <property type="gene ID" value="Cyan10605_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1958"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2079"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_220736_2_0_3"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="368" mass="41249" checksum="C88228B3A6A96E7D" modified="2013-03-06" version="1">MELSELKKDISIISERLGKTQDYLDLPNLNAQIRDLEQVAAQPEFWEAGEKAQETLQQLNDFKSLWDTFHQWQSSLEDTKAIVELLEMELDSELFNEAQCNLKSLAQDLDKWELQQLLSGTYDQKGAILTINAGAGGTDAQDWAQMLLRMYTRWAENQNYRVTLTELSEGDEAGIKSATLEIDGKYAFGYLKGEKGTHRLVRISPYNANGKRQTSFAGVDVMPSLGEEAIKIDIPEKDLEVTTSRAGGKGGQNVNKVETAVRIVHIPTGIAVRCTQERSQLQNKEKALAILKGKLLVILEEQRAKAIADIRGDIVEAAWGNQIRNYVFHPYQLVKDVRTNVETAAVDDVLDGNLEAFIEAYLRESTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P1</accession>
    <name>K9Z6P1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220141.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2333"/>
    <dbReference type="EnsemblBacteria" id="AFZ54417">
        <property type="protein sequence ID" value="AFZ54417"/>
        <property type="gene ID" value="Cyan10605_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2333"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2477"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_1_0_3"/>
    <dbReference type="OMA" id="YSARTHY"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="10127" checksum="E0D10D8CB692AC60" modified="2013-03-06" version="1">MTWKIEFSRNTLKDAKKLKSAKLDGNLKELLNILKSNPYEPPYEKLSGNLKGYYSRRINIKHRLVYRVDDNNKTIKILSVWSHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R2</accession>
    <name>K9Z6R2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2755"/>
    <dbReference type="EnsemblBacteria" id="AFZ54824">
        <property type="protein sequence ID" value="AFZ54824"/>
        <property type="gene ID" value="Cyan10605_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2755"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183313_0_0_3"/>
    <dbReference type="OMA" id="EGYMFTH"/>
    <dbReference type="OrthoDB" id="1632646at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="237" mass="27313" checksum="99B99A0AF4B0053B" modified="2013-03-06" version="1">MSNSNWFEKIPSWVWWSLTPYFGGFSFIYAGWKIKNNRWVLWGIVFIFGSIITGGFIGSFSNFLILIMPLIQLATAFKFKQEFLVKTAPKNILISSLEIAESIAKYRGKIDINNCSQDDLVYGLGLPIVYANDLQLLKEEGYMFTHLEELVDLVGIPEQILRRIEPLIIFTYDINKETDISWRRLNSLSIQELVSHGIDDVNAEKIVSERNQKGAYKSLLDIKKRTGIPINIYRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S1</accession>
    <name>K9Z6S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54442">
        <property type="protein sequence ID" value="AFZ54442"/>
        <property type="gene ID" value="Cyan10605_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2359"/>
    <dbReference type="HOGENOM" id="CLU_3024528_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="55" mass="6281" checksum="FC915EDA653EC657" modified="2013-03-06" version="1" precursor="true">MALAFILPMIMPLKWQRQTFILYFQLSQLEVSIAQAQPTASNAMIDLLTKAIQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S5</accession>
    <name>K9Z6S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase with Chase sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220561.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2771"/>
    <dbReference type="EnsemblBacteria" id="AFZ54839">
        <property type="protein sequence ID" value="AFZ54839"/>
        <property type="gene ID" value="Cyan10605_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2771"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2943"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_85_1_3"/>
    <dbReference type="OMA" id="MGDGAMI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="439"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="745" mass="84616" checksum="8B9A688860963802" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T9</accession>
    <name>K9Z6T9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PKHD-type hydroxylase Cyan10605_2787</fullName>
            <ecNumber evidence="7">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2787"/>
    <dbReference type="EnsemblBacteria" id="AFZ54854">
        <property type="protein sequence ID" value="AFZ54854"/>
        <property type="gene ID" value="Cyan10605_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2787"/>
    <dbReference type="eggNOG" id="COG3128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106663_0_0_3"/>
    <dbReference type="OMA" id="FPPLFNC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00657">
        <property type="entry name" value="Hydroxyl_YbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041097">
        <property type="entry name" value="PKHD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023550">
        <property type="entry name" value="PKHD_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41536">
        <property type="entry name" value="PTHR41536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18331">
        <property type="entry name" value="PKHD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="29243" checksum="AE9BE3B34DE60717" modified="2013-03-06" version="1">MDEIRTIIYFSRHLQEIFWFLLRAEALFYMILQLENILTPEILQTINHQLEEAKFIDGKKTAGWHAVKVKNNEQLSNQFSEIRNLEKIIYQALNENIVFQMATIPKKIHSLRFSRYSQGMGYGSHVDDALMKEGRTDISFTIFLNSPQEYEGGELILEEVNEERSFKLSTGTIIFYPSYSLHRVETVTKGVRKVVVGWIESWIRDVQKREILFDLDTVRRSIFHKQGKTAEFDLLSKSYSNLLRFFADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z721</accession>
    <name>K9Z721_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220089.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54365">
        <property type="protein sequence ID" value="AFZ54365"/>
        <property type="gene ID" value="Cyan10605_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2281"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2423"/>
    <dbReference type="eggNOG" id="ENOG50334NS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193729_0_0_3"/>
    <dbReference type="OMA" id="MSLIHWD"/>
    <dbReference type="OrthoDB" id="2088321at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="7419" checksum="662AC426F9A541B9" modified="2013-03-06" version="1">MSVVHWDKSVLSLHLKEIIEDHNRGDRTALAGLGAILVGTVVIPATAKMAKPILKQIIKGGLSISHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E6</accession>
    <name>K9Z7E6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ordered locus">Cyan10605_2212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220023.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2212"/>
    <dbReference type="EnsemblBacteria" id="AFZ54298">
        <property type="protein sequence ID" value="AFZ54298"/>
        <property type="gene ID" value="Cyan10605_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2212"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2351"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_3"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="40943" checksum="E9D7C5FF34352FA3" modified="2013-03-06" version="1">MDVNGKPYRTIWLKSDNPEIVQVIDQRFLPHQFVIEDLVTLEDVCDAIASMHVRGAGVIGASGAYGMYIASLEAKRNNISDIQSFLINASEKLKATRPTAVNLSWAVNRQLEAIIPLKDDIEAIITKTLQIANTVADEDVDFCQNIGKHGVRLIEEISQRKQGETVNILTHCNAGWLGCVDNGTATSPIYEAHRRGIKVHVWVDETRPRNQGSTLTAWELGQQGINHTIIPDNAGGHLMQHGLVDIVIVGSDRTTYTGDVANKIGTYLKAVAAKDNNVPFYVALTYSAFDWNISDGVKQIPIEQRDATEVKYIKGLHEGKIKEVLIAPENSPAANYGFDVTPARLITGLITERGICQASKEGIFSLYPEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M7</accession>
    <name>K9Z7M7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="7" type="ordered locus">Cyan10605_2509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220313.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2509"/>
    <dbReference type="EnsemblBacteria" id="AFZ54590">
        <property type="protein sequence ID" value="AFZ54590"/>
        <property type="gene ID" value="Cyan10605_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2509"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2660"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_3"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="74"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="326"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="466" mass="51211" checksum="2508C67241A75F8E" modified="2013-03-06" version="1">MLLTEKLSGEKLVNSSNSPSPNQRLLPLTAKINDKNHLEIGGCDVVDLVKQYGSPLYILDEKTLRTCAIQYRDAFKEYYPGESQVIYASKAWSCMAIVSILASEGIGFDVVSGGELFTTTKALEMSGYNGDDIKEKIYLHGNNKSIAELELAIDAGCKIIVDNWLELETLAQLTAKKEQSAKILIRLTPGIECHTHEYIRTGSIDSKFGFDLNQLEAVFTFIKEQNFIECIGLHAHIGSQIFELEPHNDLGGVLADWFKKALDYGLPLTELNVGGGLGIRYTESDDPPSIADWVKTVATAVTKACEERGLALPKLIAEPGRSMVATSCITAYTVGGKKVIPDVRTYISVDGGMSDNPRPITYQSLYQMAIASKMDQEHSETVTVAGKHCESGDILIKDIQLPDTNPNDILVVFATGAYNYSMASNYNRIGRPAAVLVNEGESSLIIRRETYDDLVRQDLLPTRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P7</accession>
    <name>K9Z7P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220333.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2529"/>
    <dbReference type="EnsemblBacteria" id="AFZ54610">
        <property type="protein sequence ID" value="AFZ54610"/>
        <property type="gene ID" value="Cyan10605_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2529"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503191_0_0_3"/>
    <dbReference type="OMA" id="PKQGYEY"/>
    <dbReference type="OrthoDB" id="1201323at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="310"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="541" mass="59402" checksum="13E130990DBB49A8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X0</accession>
    <name>K9Z7X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase (NAD(P)(+))</fullName>
            <ecNumber evidence="3">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220217.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2411"/>
    <dbReference type="EnsemblBacteria" id="AFZ54493">
        <property type="protein sequence ID" value="AFZ54493"/>
        <property type="gene ID" value="Cyan10605_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2411"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2555"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_3"/>
    <dbReference type="OMA" id="WHKLIEQ"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="454" mass="49786" checksum="ADD34C58F206041D" modified="2013-03-06" version="1">MAIATVNPTTEETLKIFTPLTAEEIEKKLHLAETTFQQYRLTSFAHRREKLLKAGEILENNARKWAEIITLEMGKPIKQALAEIKKCALVCRYYAENAESFLKPKTIASDASYSVINYQPLGIILAVMPWNFPFWQVLRFATPALMAGNVGLLKHASNVPQCANAIASIFLEAGFPEGVFQSLLITSNQVEGVLRDKRVKAVTLTGSELAGRKVASVAGDELKKSVLELGGSDPFIVTKSANIEEAVKVAVTARMLNNGQSCIAAKRFILEDAIAPKFTELLLQEYQKLKIGNPFDETVDIGPLATANILEDIVQQVDETIAKGAKVLIGGKPLEGKGYFYPPTILTDIPVNSPGMNEEFFAPVALIFTVKNIEEAIILANSTNFGLGASIWTNNQTEIDLAVRDIEAGSVFINGMVKSDPRLPFGGIKRSGYGRELSMEGMLEFMNIKTVWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z0</accession>
    <name>K9Z7Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein, PhoT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220236.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2432"/>
    <dbReference type="EnsemblBacteria" id="AFZ54513">
        <property type="protein sequence ID" value="AFZ54513"/>
        <property type="gene ID" value="Cyan10605_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2432"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2576"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30934" checksum="281D20E35E1EBAD9" modified="2013-03-06" version="1">MEESYKNQEDYQQQEPVLQLRDVDIYYGNYKAVRGVNLDIAKNQITAFIGPSGCGKSTILRCLNRLNDLISSFKLKGRVTYHGQDLYHKDIDPVEVRKRIGMVFQRPNPFPKTIYDNIAYGARVNGYKGDMDELVETSLRRAVLWDEVKDKLGESGFSLSGGQQQRLCIARTIAAQPEVVLMDEPCSALDPISTLKIEELMHELKENYTIVIVTHNMQQATRVADMTAFFNAEAIGDKGNKIGYLVEFDRTEKIFSDPREEATRDYVSGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z855</accession>
    <name>K9Z855_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221094.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3333"/>
    <dbReference type="EnsemblBacteria" id="AFZ55376">
        <property type="protein sequence ID" value="AFZ55376"/>
        <property type="gene ID" value="Cyan10605_3333"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3333"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3550"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_6_3_3"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="462" mass="50111" checksum="BEA0811D4C46B6A0" modified="2013-03-06" version="1">MTIPNNEKLSIRTEAQEFLKLAVPLAGAQVAQLTTGFADTVMMGHLGNEILAAGGLASITFFSIMIATSGIVMGVTPLVATAYGAENKTDIEQFTRQGLWLSLLLSIPIMVATAHFDSLVSGLGLDETMLKSVKTYLDIMLWGLFPALGFAMLRGVVSALSQARPIFLIVTIGTGLNILGNYVLGFGALGFPRLELAGLALASTVTLWGMFVALIIYLSVSHHFESYKFFSSLYQLKPKKLWKLFKIGLPIGVFSTLEIGTYTVVSYLVAEFGANGLAAHQIVFQTINIIYMVPLGMSFAATARVGKWFGQNNMVGIRQAGLVGIVLGTLWTTVIVVVLLVFPQQIVGLYIDVLKPESEPIVSLAVSILRVGAIAHIFDGVQKIAYGALQGLQDTRVPMILSFLFYWCIGLICGYWLAFSWNLDVIGLWLGLLIAVAIASVVFVWRFQALGMNNIRIKLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z876</accession>
    <name>K9Z876_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220498.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2702"/>
    <dbReference type="EnsemblBacteria" id="AFZ54775">
        <property type="protein sequence ID" value="AFZ54775"/>
        <property type="gene ID" value="Cyan10605_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2702"/>
    <dbReference type="eggNOG" id="ENOG502ZBUS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128328_0_0_3"/>
    <dbReference type="OMA" id="LANLPYW"/>
    <dbReference type="OrthoDB" id="1685614at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010840">
        <property type="entry name" value="YqiJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07290">
        <property type="entry name" value="DUF1449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="27377" checksum="6F6F2525F79853A5" modified="2013-03-06" version="1">MLFDIANLTYWIFLGIGVLLFLFVIISGGGEDQDLDTDVNFDSDIDVDTDVDFDADVDGDVDGDIDHNLKTDLDEGVEATIFSFLSWFGLGKCPLMILLAIDFSTWGVTGWFLNVLVGGLLNAIPTGFIGFLIFFLSFCFSVWVGRVLSVPIGKIFANAGENVEGDRLVGCSGEVTSSKVPYIVEGRIAQADILDSASNLVTVEICLPEWAQVIPSKGQEVLIIEKRQHCFLAIAKDSSDQDKWFNSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A0</accession>
    <name>K9Z8A0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220677.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2891"/>
    <dbReference type="EnsemblBacteria" id="AFZ54957">
        <property type="protein sequence ID" value="AFZ54957"/>
        <property type="gene ID" value="Cyan10605_2891"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2891"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3072"/>
    <dbReference type="eggNOG" id="COG4634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150003_3_2_3"/>
    <dbReference type="OMA" id="PPKFIYL"/>
    <dbReference type="OrthoDB" id="1805280at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12962" checksum="8B44A355FB0D00F0" modified="2013-03-06" version="1">MKLLLDENLSDRIIHKIIDLYPDSHHVKTLSLLNTDDSLIWEFAKFNDFVIVSKDSDFHQRSLLYGYPPKFIYLRIGNNPTSKIVEILRDNFSIIREFYNSETESILILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D4</accession>
    <name>K9Z8D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HtrA2 peptidase</fullName>
            <ecNumber evidence="2">3.4.21.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.108" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220562.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2772"/>
    <dbReference type="EnsemblBacteria" id="AFZ54840">
        <property type="protein sequence ID" value="AFZ54840"/>
        <property type="gene ID" value="Cyan10605_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2772"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_2_3"/>
    <dbReference type="OMA" id="THGWVLE"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="302"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="43091" checksum="6A08A186CA7BA907" modified="2013-03-06" version="1" precursor="true">MNKLISQIFVSSSLLIMGTALGVWGSRQLATLNQSSVSDTIPPETSLQPVANSVFPPFKQSSPQKQGNFNFISEVAQKVGPAVVRIEATRQVSFNNSENFEHPLFKHFFPEQIPFERTERGTGSGFIVSDDGLIMTNAHVVEGTSFVSVLLPSGKTYEGRVLGIDSMTDVAVVKITAENLPTVILGKAKNLIIGEWAIAIGNPLGLDNTVTVGIISAKDRSSSEVGVSDKRVKFIQTDAAINPGNSGGPLLNARGEVIGINTAIRADAQGLGFAIPIETASRIAEQLYTTGKASHPYIGIQMITLNQDTIKNDNIPQNLGFENVPEKGVLVVKVMENSPASQAGFLPGDVINNVNNIEVLTAQDVQEQVEISTIGEVIPIRIDRQGKFITLKVYPAEFPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U0</accession>
    <name>K9Z8U0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220734.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2953"/>
    <dbReference type="EnsemblBacteria" id="AFZ55015">
        <property type="protein sequence ID" value="AFZ55015"/>
        <property type="gene ID" value="Cyan10605_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2953"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3142"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="IIFIDIM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="13740" checksum="646C528436EF1985" modified="2013-03-06" version="1">MSTVLLVEDSIPTRKMISELLTKQGFNVEVATDGIQALEVLPNLRPDLVILDIIMPKMNGYEVCRKIKSDPQTKDLPVIICSSKGEDFDRYWGIKQGADAYIAKPFREKELIATIKQFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V9</accession>
    <name>K9Z8V9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyanate ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220876.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3104"/>
    <dbReference type="EnsemblBacteria" id="AFZ55157">
        <property type="protein sequence ID" value="AFZ55157"/>
        <property type="gene ID" value="Cyan10605_3104"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3104"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3308"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037398_3_1_3"/>
    <dbReference type="OMA" id="WDGHPCC"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="538" mass="59130" checksum="8F02C7038A3BF1E3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z989</accession>
    <name>K9Z989_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220673.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2887"/>
    <dbReference type="EnsemblBacteria" id="AFZ54953">
        <property type="protein sequence ID" value="AFZ54953"/>
        <property type="gene ID" value="Cyan10605_2887"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2887"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3068"/>
    <dbReference type="eggNOG" id="ENOG5032J5S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2014260_0_0_3"/>
    <dbReference type="OMA" id="KNHIGES"/>
    <dbReference type="OrthoDB" id="1860980at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="146" mass="17036" checksum="EC5370DC984789B4" modified="2013-03-06" version="1">MIKIEIFINEISLSCCIQIVKNNDEQNKIYLDSTESKTGLENWLEKNCQLSQFQYDESSSSPPTDNQTILRNSSRFEKIGREYDGRSIYREKKTGYYWYVDNLHCGEAAHLEVFDSHGKKHIAESNLEGNIDKTKSDPDKRIDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z997</accession>
    <name>K9Z997_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">Cyan10605_2901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220682.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2901"/>
    <dbReference type="EnsemblBacteria" id="AFZ54963">
        <property type="protein sequence ID" value="AFZ54963"/>
        <property type="gene ID" value="Cyan10605_2901"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2901"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3089"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_3"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="294"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="476"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="625" mass="69535" checksum="A36A6805DA733095" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A7</accession>
    <name>K9Z9A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220692.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2911"/>
    <dbReference type="EnsemblBacteria" id="AFZ54973">
        <property type="protein sequence ID" value="AFZ54973"/>
        <property type="gene ID" value="Cyan10605_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2911"/>
    <dbReference type="eggNOG" id="ENOG5032YHH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171899_0_0_3"/>
    <dbReference type="OrthoDB" id="2039087at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9923" checksum="D6F7F4EB5DDFB40B" modified="2013-03-06" version="1">MSEYKFTQYFENDVLLKRPYLKKEWCIRVIQNPLKCEPQENNRFRFWGIIPEFDNKILRVITLENKTTIHNAFPDRRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D4</accession>
    <name>K9Z9D4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">Cyan10605_3291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221055.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3291"/>
    <dbReference type="EnsemblBacteria" id="AFZ55337">
        <property type="protein sequence ID" value="AFZ55337"/>
        <property type="gene ID" value="Cyan10605_3291"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3291"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3506"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_3"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="31972" checksum="0D3FC3009A191FFE" modified="2013-03-06" version="1">MLVDSLFLLKFQSPGPILFELGPISLRWYGFLIASAVLIGVILSQKLATYRRVDPELIGDLVIWLVIGAIPAARIYYVLFEWQNYAQHPQDIIAIWQGGIAIHGAIIGGAIAGLIFAKTHRQSFWQLTDIIAPSLILGQAIGRWGNFFNSEAFGTPTDLPWKLYIPPNNRPLQYINFDYFHPTFLYESIWNILVFMLLISLFFWGIKHSNKLKVGTISFVYLIAYSCGRVWIEGFRTDSLMFGYLRVAQLVSLGAIAFGIFGLIWLYGLKKSLPDVYKPTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V0</accession>
    <name>K9Z9V0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HcyBio domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221215.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3460"/>
    <dbReference type="EnsemblBacteria" id="AFZ55497">
        <property type="protein sequence ID" value="AFZ55497"/>
        <property type="gene ID" value="Cyan10605_3460"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3460"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3685"/>
    <dbReference type="eggNOG" id="COG1900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043239_0_0_3"/>
    <dbReference type="OMA" id="WVRGCYF"/>
    <dbReference type="OrthoDB" id="390505at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002708">
        <property type="entry name" value="HcyBio"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01837">
        <property type="entry name" value="HcyBio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HcyBio" evidence="1">
        <location>
            <begin position="16"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="389" mass="42421" checksum="C68920DBDA19B382" modified="2013-03-06" version="1">MRTINEINEKILQKKARVCTIEELKAKVKKIGIKKTYEKVDVICAGTFEPMESSGAILNLGHTDPPMKIRHCWLDGVPAYAGFGAVDLYLGATALPDVNDAENTVIPEKGGAHVIESLIAGNSVSVKAIGQVTDCYPRASFDATININSINQFYLYNPRNLYQNFIVGVNGGDRILYTYLGPLLPRLGNAVYSNIGALSPLLNDPYLEAIGIGTKIFLGGAEGMITWEGTQHFPLQKRSTNGTPIGPASTLALVGDAKKMDRKWVRGCYFKNYGASLMLGVGIPFPVLNEKIVENCAVEDKDIYAPVMDFSIPRRVRPSFGLVNYAQLKQGKIKIEGQIVKVASVASLYLSRQVAETLKQWILDGKFTLTEAVSPLPSSTTFISQDGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Z8</accession>
    <name>K9Z9Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221264.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3514"/>
    <dbReference type="EnsemblBacteria" id="AFZ55547">
        <property type="protein sequence ID" value="AFZ55547"/>
        <property type="gene ID" value="Cyan10605_3514"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3514"/>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122734_0_0_3"/>
    <dbReference type="OMA" id="YRILYFF"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="14918" checksum="5BD70B11BB8B693F" modified="2013-03-06" version="1">MPQIKIIFYQEQNGKVPLLEWLDRLPNKVQTKCFVKLERLSQLGHELRRPEADLLRDNIYELRIGFQVINYRILYFFYKNQAIIVSHGLTKEKRVPPLEIDKAITNKNKFEQNPELHTYYQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA04</accession>
    <name>K9ZA04_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ</fullName>
            <ecNumber evidence="2">2.1.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA Cm32/Um32 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmJ</name>
        <name evidence="4" type="ordered locus">Cyan10605_3132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42936"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10290"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42932"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10289"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.200" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3132"/>
    <dbReference type="EnsemblBacteria" id="AFZ55183">
        <property type="protein sequence ID" value="AFZ55183"/>
        <property type="gene ID" value="Cyan10605_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3132"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3338"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_3"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="30531" checksum="F3AD84F006F69E6C" modified="2013-03-06" version="1">MINGRILECFFPSYRSHHLATMTVIDSVRIVLVEPAGERNIGSIARVMRNMGLTKLVIVNPHCNPLSEEAKVMAVHGVEVLEKAKIVNSIPSALQGCQRAIATTARERGIPTPLEKPRDVMGWLLEENINSALVFGPEDRGLSNQELSYAQRFVCIPSNPEYPSLNLAQAVGVCAYELYQEFLNQNQKTVIDTETEKQDDLADLKALEGYYQHLESVLLQVNYLYPHTAKATMEKIKRIVNRSDLKTQELAMLRGMLRQVEWGIKSHTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAH1</accession>
    <name>K9ZAH1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3557"/>
    <dbReference type="EnsemblBacteria" id="AFZ55590">
        <property type="protein sequence ID" value="AFZ55590"/>
        <property type="gene ID" value="Cyan10605_3557"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3557"/>
    <dbReference type="HOGENOM" id="CLU_3215169_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="44" mass="5039" checksum="E8BFEB60922176A6" modified="2013-03-06" version="1">MLIINKNIFSNLNSAINYYLSLSDCLIVAGETELVNLFWDKLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAK9</accession>
    <name>K9ZAK9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221151.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3391"/>
    <dbReference type="EnsemblBacteria" id="AFZ55433">
        <property type="protein sequence ID" value="AFZ55433"/>
        <property type="gene ID" value="Cyan10605_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3391"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3611"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066336_2_0_3"/>
    <dbReference type="OMA" id="ETLECDY"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044213">
        <property type="entry name" value="At2g44920-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47200">
        <property type="entry name" value="PTHR47200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938731" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17235" checksum="8A98411A391C6B81" modified="2013-03-06" version="1" precursor="true">MVFSQVISLVLALIIAFFSVSPSAEALDYTKRDLAEVDFSGQNLTDATFNKTNLRSANLSQSDLQGVSFFGANMDSINLEGANLTNSILDSARLTRANLRNAVLEGAFATNTKFEGANIEGADFTDVILRPDVEEMLCEKAKGVNPTTGRKTRDTLYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAT3</accession>
    <name>K9ZAT3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3467"/>
    <dbReference type="EnsemblBacteria" id="AFZ55503">
        <property type="protein sequence ID" value="AFZ55503"/>
        <property type="gene ID" value="Cyan10605_3467"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3467"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="OMA" id="KDELYGM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="14833" checksum="C094B8FBFE2FD043" modified="2013-03-06" version="1">MVGKRQEAKGKSVKIFFDIKDFKMSEIKDFKDLIIWQKGMEIAEQCYFVTKKFPKEELYGMVLQIRKSSSSIPANISEGYGRKSSRDYKRFLSIAQGSVNETETHLLLSARVGLCTLKDIETIINNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ13</accession>
    <name>K9YZ13_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217903.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0010"/>
    <dbReference type="EnsemblBacteria" id="AFZ52171">
        <property type="protein sequence ID" value="AFZ52171"/>
        <property type="gene ID" value="Cyan10605_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0010"/>
    <dbReference type="eggNOG" id="ENOG5033ENJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2552574_0_0_3"/>
    <dbReference type="OrthoDB" id="1955589at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9545" checksum="99A41B8D85F2F526" modified="2013-03-06" version="1">MRIIETKINITDEHLLNIKLPEDITVGEYEIAIIINPVTKSTNSHPINQLAGKVKAFKNINSVEWQKEIRGEWDEIRLSDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZG3</accession>
    <name>K9YZG3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ordered locus">Cyan10605_0185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0185"/>
    <dbReference type="EnsemblBacteria" id="AFZ52341">
        <property type="protein sequence ID" value="AFZ52341"/>
        <property type="gene ID" value="Cyan10605_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0185"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.193"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_3"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="10"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="87"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="534" mass="58670" checksum="6E023FAAF534ED95" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZH3</accession>
    <name>K9YZH3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="7" type="ordered locus">Cyan10605_0157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218046.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0157"/>
    <dbReference type="EnsemblBacteria" id="AFZ52314">
        <property type="protein sequence ID" value="AFZ52314"/>
        <property type="gene ID" value="Cyan10605_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0157"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.163"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_3"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="13529" checksum="D37601634ACB01A1" modified="2013-03-06" version="1">MSDKVANIVEELKTLTLLEASELVKQIEEVFGVSAAAPAGGMMMMAPGAAAPAEEVEEKTEFDVILDSFGDAKMGVLKVVRAITGLGLKEAKELVESAPKAIKEGINKEEAENIKKQLEEAGGKVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZX2</accession>
    <name>K9YZX2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="5" type="ordered locus">Cyan10605_0316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218196.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0316"/>
    <dbReference type="EnsemblBacteria" id="AFZ52464">
        <property type="protein sequence ID" value="AFZ52464"/>
        <property type="gene ID" value="Cyan10605_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0316"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.329"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_3"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="31848" checksum="4DBAB91A12AEEF3A" modified="2013-03-06" version="1">MEAIKIGIIGGSGLYKMEALQNIEEITIETPFGKTSDNLITGTLDGEKVVFLPRHGRNHHLLPSELPFQANIYALKQLGVEYIISASAVGSLQKEIKPLDLVIPDQFIDRTKNRPATFFGEGIVAHVAFGHPTCPQLGKILAKAITNLNLEDIELHEGGTYICMEGPAFSTIAESNLYRSWGASIIGMTNLTEAKLAREAEIAYATLALVTDYDCWNPEHDHVTVETVIQNLHQNAVNAQKVIRETVKLIAENPFVSKAHSALKDAIITPLNNAPEATKEKLSLLLKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0A1</accession>
    <name>K9Z0A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218357.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0484"/>
    <dbReference type="EnsemblBacteria" id="AFZ52626">
        <property type="protein sequence ID" value="AFZ52626"/>
        <property type="gene ID" value="Cyan10605_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0484"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.513"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="37384" checksum="C101BD5FE686637C" modified="2013-03-06" version="1">MSSDVIVVEKLHKNYGQVQAIKNISFRVKAGEIFGLLGPNGAGKTTTIRCLTTLAKPDGGEVLVGGVSAITQPKKVREIIGYVAQEVAIDKVLTGRELLNLQASLYHLPASCRKERIDQLLQLLGLQEYCDRQCGTYSGGIRKRLDLAAGLLHKPKVLILDEPSVGLDIESRMIIWDFLRQLKKSGTSVLITSHYLEEIDALADSLAIIDQGEVIAQGSPSSLKDRLGGDRITLRIREFTPESEVETAKNQLSSLPFVQEIIINQAQGNSLNLIVKPQNNSLTTIEKTLTEANLPIFSISQSRPSLDDVYLAATGRTLMDAEIEGINKRDLKAEKKQAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0C5</accession>
    <name>K9Z0C5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218350.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0477"/>
    <dbReference type="EnsemblBacteria" id="AFZ52619">
        <property type="protein sequence ID" value="AFZ52619"/>
        <property type="gene ID" value="Cyan10605_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0477"/>
    <dbReference type="eggNOG" id="ENOG502Z83E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074052_0_0_3"/>
    <dbReference type="OMA" id="QIWSGII"/>
    <dbReference type="OrthoDB" id="1049330at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938568" evidence="1">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="28643" checksum="33215707B5BD0099" modified="2013-03-06" version="1" precursor="true">MNKTNKFLLLILLGLSLNITQFKQVKAQSNNIPSNLLEIVTKIDSAANNKDIELLAENISPEFASSDGINSESLQEYLEKMWSKYPDLKYTTSIESWEEKQGELSAVTLTKIEGSYESGGKKFVLNSEIKANQYFSNNQLIKQDIISEKTEITSGENPPQARVNLPAKVNVGQEFDFDVILEEPVGSDIVLGGVSEEKVSPSLYLEPSSIELDALTAGGIFKRVKLPVTDNQDHWYSVILIRDGGIRMITQRVKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D4</accession>
    <name>K9Z0D4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218360.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0487"/>
    <dbReference type="REBASE" id="58413">
        <property type="entry name" value="M.Cap10605ORF487P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52629">
        <property type="protein sequence ID" value="AFZ52629"/>
        <property type="gene ID" value="Cyan10605_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0487"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.516"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_6_0_3"/>
    <dbReference type="OMA" id="DPPYYVK"/>
    <dbReference type="OrthoDB" id="1206955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="283" mass="33365" checksum="5513D276D02BDDC5" modified="2013-03-06" version="1">MIKSPLRYPGGKSRAIDYLCQHLPDDFSEYREPMVGGGSMFIYLKQKNPGLKIWINDLNPELYLFWKIAQSDLVNLVNEIKKCKENYQDGKQLFRELTTVNIENLTDLERATRFFILNRITFSGTVESGGFSQGAFEKRFTDSSIERLELLEQILKDITITNLDFENVIKDNSNNAFLFLDPPYYNNAKSKLYGKKGNLHSEFNHKKFINIIKKCQHKWLITYDNCKFIKDNFVEYYLQEWELQYGMNNYKKSSVPKGKELLIMNYLPSIQDKQNQQLTLNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M0</accession>
    <name>K9Z0M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroorotase</fullName>
            <ecNumber evidence="1">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218425.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0553"/>
    <dbReference type="EnsemblBacteria" id="AFZ52694">
        <property type="protein sequence ID" value="AFZ52694"/>
        <property type="gene ID" value="Cyan10605_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0553"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.583"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_3"/>
    <dbReference type="OMA" id="ASTTWMH"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="417" mass="46021" checksum="E608D77769A6741E" modified="2013-03-06" version="1">MNQTLLFQQIRTLDPVSGFDQVTDILIDDNKIQEISPKIELTDDSAKIIDGNGLILAPALVDLFCHSGEPGYEERETLQTLNASAKAGGVSRVAILPNTLPVVDNPNTVTWIQNKTKSLETNFDCWGSLTKNLEGNTIAELADLAESGVVGFTDNRPHSNLQLVRKLLEYAQPFHLPIALCPTNLQLKGKGVVRECRTSIRLGLIGNPEIAETVAIASLLEIVALTKTPIHLMNISTARGVDLIKRAKEEQLPVTGSVNWHHLILNIETIASYNPHLRFDPPLGTEIDRLGLLEGIKTGVIDAISINHTPYTYEEKTVAFADAPSGSIGLELALPLLWQNLVITGELSASQLWKALSVNALKCLYQEPLKIQIGQRAEFIVFAPQQPWQITPNQLKSLSYNTYWLEKEIKGKILCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R3</accession>
    <name>K9Z0R3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218475.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0605"/>
    <dbReference type="EnsemblBacteria" id="AFZ52744">
        <property type="protein sequence ID" value="AFZ52744"/>
        <property type="gene ID" value="Cyan10605_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0605"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.638"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="KARKYEV"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="270" mass="30978" checksum="F603EEE34B1656D7" modified="2013-03-06" version="1">MVCIAIIEGNPHLRSLLGWHLQQVGYIINQCGSIQQAKQNLANQSPTLVVLDSDLPDGDGFEFCQWLCQCHQPLILMLSAQTTEKDVVKGLKAGADDYLKKPFGMQEFLARVESLLRRFRTNNAPLSLDFGDLKIDLVQRRVEFRGQFIDLTPQEFSLLYVLSQAQGIPLSRSELLRKAWPEAIENQRTIDTHVLSLRKKIELDPRQPNVIQTVRNVGYRFNLEALQKQSYYLPPENITPSNNNHHSLNHNSHYSYNNNGRVFHDKVMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z136</accession>
    <name>K9Z136_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218647.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0783"/>
    <dbReference type="EnsemblBacteria" id="AFZ52916">
        <property type="protein sequence ID" value="AFZ52916"/>
        <property type="gene ID" value="Cyan10605_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0783"/>
    <dbReference type="HOGENOM" id="CLU_2632206_0_0_3"/>
    <dbReference type="OrthoDB" id="2049946at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="8896" checksum="0648FB16ADB52571" modified="2013-03-06" version="1">MKKNNNGNYINLSSQDFKDYHYPSPEKFNSPSLHRDLQSFSQQVSYLSALHTNGKISTSVAYFKLDHLWQSLNSVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B6</accession>
    <name>K9Z1B6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218727.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0865"/>
    <dbReference type="EnsemblBacteria" id="AFZ52996">
        <property type="protein sequence ID" value="AFZ52996"/>
        <property type="gene ID" value="Cyan10605_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0865"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_6_4_3"/>
    <dbReference type="OMA" id="PHVEMRK"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16689" checksum="89C6A6E8421F94C6" modified="2013-03-06" version="1">MQPEIIIGDYQQLKTECNLIRYRVFVIEQNVPETLELDDRDSICIHLLLKLNNYYIGTGRIDLQQQGKIGRLAVLPSFRNKGYGQIILHNLELVARENQLNSVWLNAQKQSLNFYLKSGYNTISDEFLEANIPHLKMIKYFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D6</accession>
    <name>K9Z1D6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218747.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0886"/>
    <dbReference type="EnsemblBacteria" id="AFZ53016">
        <property type="protein sequence ID" value="AFZ53016"/>
        <property type="gene ID" value="Cyan10605_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0886"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.931"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_0_1_3"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="263" mass="30734" checksum="7E2455C03B52FDA3" modified="2013-03-06" version="1">MKIATWNVNSIRTRQEHVKNWLLEHDIDIICLQETKVIDQDFPVETFNDIGYKTYIYGQKSYNGVAIFSKKPLDKIDYGFSGILEKNADNLDEQKRVISGVFNNIRIVNLYVPNGNSVGSEKYEYKLTWLKKLSEYLIELKDKHSEEILVCGDFNIALEDIDIYNPKGKKDHIMASIPERDSLTNIMDLGFRDAFRKFTQEGNHYSWWDYRHGGFSKNRGWRIDHIYLTSSLYEKASNCYIDINPRKLEKPSDHAPVVCEFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K2</accession>
    <name>K9Z1K2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tic20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217955.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0062"/>
    <dbReference type="EnsemblBacteria" id="AFZ52223">
        <property type="protein sequence ID" value="AFZ52223"/>
        <property type="gene ID" value="Cyan10605_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0062"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.64"/>
    <dbReference type="eggNOG" id="ENOG502ZXE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094758_1_0_3"/>
    <dbReference type="OMA" id="IFACLPY"/>
    <dbReference type="OrthoDB" id="1828578at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510">
        <property type="entry name" value="PTHR33510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17935" checksum="5A0B3B8C9F85FB8A" modified="2013-03-06" version="1">MNWRTSSTDWKDRLFASLVYLFPLYYALEFGSFLFGQFPFLQLIIIPLYPLILINQIPFGGFILFIVLFAAVVRNARISHFIRFNTMQAILIDILLILVGLVFNVIFRGLGTSLLTETISNALFLGTLVACGYGIFQSASGKYAEMPTISEAAYSQVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T2</accession>
    <name>K9Z1T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium uptake protein, TrkH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218850.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0990"/>
    <dbReference type="EnsemblBacteria" id="AFZ53119">
        <property type="protein sequence ID" value="AFZ53119"/>
        <property type="gene ID" value="Cyan10605_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0990"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1047"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_0_1_3"/>
    <dbReference type="OMA" id="MFIGSAP"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="445" mass="48809" checksum="2360F19F50C173B3" modified="2013-03-06" version="1" precursor="true">MTIARTICLGFIAVISVGTILLMMPFAVETGNWGSFITALFTSTSAVCVTGLIVVDTGTYFSFWGELIILCLIQIGGLGYMTTSTFLILLIGKKFDFRQKIAISESFDRPFLQGSRNLVISIFVTTFILEIIATIVLYSIFSQDYGWKQGLWLAIFHSVSAWNNAGFSLFPDSLIQYQSSIPINIVITALIILGGIGYQVIIEVFLWFLDFFKQKVHPHYEFSLNFKVVTRTTLILLILGTVGFFITELHNNNTLAELPFKDKIITAWFQSVTTRTAGFNSIDIGAMTKAGLFITIGLMFIGASPSGTGGGIKTTTLSILYNSTKAVLRGQEQVVMHKREVPVSLILKAMAVVFGSGVTVVCITFFISLLHSDFEFQSIFFEVVSAFATVGLSTGITSSLSVLAKLAIVFTMYLGRVGVLLFMAAIVGDPQPSRIEYPEENLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z5</accession>
    <name>K9Z1Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218145.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0263"/>
    <dbReference type="EnsemblBacteria" id="AFZ52413">
        <property type="protein sequence ID" value="AFZ52413"/>
        <property type="gene ID" value="Cyan10605_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0263"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923530_0_0_3"/>
    <dbReference type="OMA" id="FIDHHAI"/>
    <dbReference type="OrthoDB" id="1267669at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="37633" checksum="14DE152181C0B121" modified="2013-03-06" version="1">MLISDLKGGLFKYEVKDYYAILGLPISASPKDIRLRYLKLAYQLHPDTNQAETRENREKASTILSKLVNPAYENLYKDKLRKECQLIFSEISMRLAPMAKEMTLSGEIPKKLLREEANFNKMYQDLIETLAKEQYQDLSKLAVKIGLLSELNMIYLVRQKQGELGKVMGGASSNVEPKIAVSEPIITAAPEQSGNTGVSQQVEEKEEKVPVSRLEKLISSAKNHIEQFNPDAALFDLREAVKIDANSAVAHAMLGSVYLLQNNLPYGRIHINKAVGIDSNNPTVKKAQEELKQKEKKSSTGKTDGKKTESKGSDKEKSKDKKGKKEPPKIFGIPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A0</accession>
    <name>K9Z2A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218249.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0373"/>
    <dbReference type="EnsemblBacteria" id="AFZ52518">
        <property type="protein sequence ID" value="AFZ52518"/>
        <property type="gene ID" value="Cyan10605_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0373"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.393"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131947_0_0_3"/>
    <dbReference type="OMA" id="ILMFESE"/>
    <dbReference type="OrthoDB" id="1639891at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021503">
        <property type="entry name" value="DUF3110"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11360">
        <property type="entry name" value="DUF3110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="14425" checksum="1EF2406CD7D36851" modified="2013-03-06" version="1">MKVYVLLYNVGTDNEGIHTLQIGNKDMVLMFESEDDATRYALLLEAQDFYSPTVESLNSEEIEEFCTGAGYEWKLVTEGMLEIPPEINVEDTDWKESADYPDDVSSEAQMSAFELERIRRQLEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A1</accession>
    <name>K9Z2A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219060.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1212"/>
    <dbReference type="EnsemblBacteria" id="AFZ53331">
        <property type="protein sequence ID" value="AFZ53331"/>
        <property type="gene ID" value="Cyan10605_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1212"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1279"/>
    <dbReference type="eggNOG" id="COG3914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022025_0_0_3"/>
    <dbReference type="OrthoDB" id="370520at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="377"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="543"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="746" mass="87566" checksum="2A4D69A80FF2573A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D3</accession>
    <name>K9Z2D3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ordered locus">Cyan10605_1183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219033.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1183"/>
    <dbReference type="EnsemblBacteria" id="AFZ53304">
        <property type="protein sequence ID" value="AFZ53304"/>
        <property type="gene ID" value="Cyan10605_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1183"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1249"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_3"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="463" mass="50614" checksum="86175A945C5F4B56" modified="2013-03-06" version="1">MNRIEKDSIGEIEVKSDRLWGAQTQRSLHHFSIGEDMMPIEVIRAFAIVKKASAMANEELGKLPLEKAKLIIQVADEILQGKLDEHFPLYVWMTGSGTQTNMNVNEVISNRAIQIVGGELGSKNPIHPNDDVNMSQSSNDTFPTAMNVASAIAIQERLIPKVKKLRDALAEKAQAWKNIIKIGRTHLQDAVPLSLGQEFSGYVGMLDDNLTRINQALPHVYQLALGGTALGTGINAPIGFATKSAHHIANITGLPFVSAPNKFTVMGSHDAIVSLSGTLKTLACSLYKIANDIRFLACGPRAGLNELELPANEPGSSIMPGKVNPTQCEALAMVAVQVMGYDTAVSFAGASGMLDMNVYKPMMIYNILQSIKILSDSCNNFTDFTIKEMKPNRQRIEELVNQSLMLVTALTPKIGYDKASKIAHLAYEKNITLKEATLELGYLTATEFDDCIDLRQMAYPHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E0</accession>
    <name>K9Z2E0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219100.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1253"/>
    <dbReference type="EnsemblBacteria" id="AFZ53371">
        <property type="protein sequence ID" value="AFZ53371"/>
        <property type="gene ID" value="Cyan10605_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1253"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1322"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065264_1_0_3"/>
    <dbReference type="OMA" id="IPMATYY"/>
    <dbReference type="OrthoDB" id="1705475at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938561" description="TPM_phosphatase domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="25138" checksum="98BACEAAEBAD6465" modified="2013-03-06" version="1" precursor="true">MNKIKYIFAYFCLSLLLLFNVGINTAFATGVYDLPVINAGEDVWVYDDADAISRATEGKLTSMLQDLAKDTGNEVRMVVINRLDYGQTIDSLATELFQTWYPTPDSAKNQTLVVVDTLSNKGAIASGDGVSNLLTPEISESLVKETLPYSLKDLQYNQALISAGDRLVAVLSGQDDPGAPQVEEISIEGTFTTAEETDDRSATIWTIVLLVLATVIPMVTYFWYVGFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E6</accession>
    <name>K9Z2E6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218289.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0414"/>
    <dbReference type="EnsemblBacteria" id="AFZ52558">
        <property type="protein sequence ID" value="AFZ52558"/>
        <property type="gene ID" value="Cyan10605_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0414"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.438"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_2_0_3"/>
    <dbReference type="OMA" id="NIFWVIE"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21390" checksum="263A7D6E095F449F" modified="2013-03-06" version="1">MLTPTKWTLDDYHKMIDAGILCDRIVEFIKGDIVEMSPEKPLHRYTNHNTVKYLRSLLQEKAEVMEAHPITLTDSEPEPDVVITRTPDELYFTRHPYPEDIYWLIEIADSTLAKDLGIKKQIYAEVGIQEYWVIDLVNQKIHVFRHPNQGDYQSKSELIEGIISPLAFPDIRVTVAKLINSSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H8</accession>
    <name>K9Z2H8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-2,4-diaminobutyrate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219135.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1291"/>
    <dbReference type="EnsemblBacteria" id="AFZ53406">
        <property type="protein sequence ID" value="AFZ53406"/>
        <property type="gene ID" value="Cyan10605_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1291"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1364"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_3"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033983">
        <property type="term" value="F:diaminobutyrate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="507" mass="56350" checksum="22E197C8958C5438" modified="2013-03-06" version="1">MSSSSQARPFDRYFLTAQTESIESYQEAIALTQELIVNNILQEDKPYFGLNPSLLQESFRDFCPKNFTQQDYPQIEPELAEIIRHGAMVTHPACVAHLHCPPLIPAIAAELIIGSLNQSMDSWDQSPSATILEQQLTRWLCDLFGYSNSADGTFTSGGTQSNLMGLLLARDNYAKTHLKWHIQRQGLPPEAQQFRIFCSDVAHFTIRQGAAILGLGENGVIPIETDENFQLKPEILSAKLRTLQQDNLRPIAIVATAGTTDFGSIDPLPELAKIARDHGLWFHVDAAYGGALKLSQNHGHKLKGIELADSITVDFHKLFYQPISCGAFLLKNQANFGLIKLHADYLNPESNEAQGIPDLVTKSIQTTRRFDALKLWLSLKTLGVETFGEMIDSTIELAGAIALIIAEDAELELANIPTINAVVFRYQPSQGTATEIDRINEQIPKKLMLEGKGIIAQTQVKGRNYLKFTLLNPLTTLKDLQKLLIEIKSLGQTLHTTDINHELKKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J4</accession>
    <name>K9Z2J4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218683.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0820"/>
    <dbReference type="EnsemblBacteria" id="AFZ52952">
        <property type="protein sequence ID" value="AFZ52952"/>
        <property type="gene ID" value="Cyan10605_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0820"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_6_1_3"/>
    <dbReference type="OMA" id="EIWLVRF"/>
    <dbReference type="OrthoDB" id="1924690at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12873" checksum="CE05D03C6E40E217" modified="2013-03-06" version="1">MIPKIREIWLVSFSFSDLTATKLRPALVIANHREEIIIIGIFSKIPHETLKETWVLVSENNPQFQETGLKKTSLIRADKIATLSQFVFKKKLGVLSVDLMEKVNLALKKSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K3</accession>
    <name>K9Z2K3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218339.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0466"/>
    <dbReference type="EnsemblBacteria" id="AFZ52608">
        <property type="protein sequence ID" value="AFZ52608"/>
        <property type="gene ID" value="Cyan10605_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0466"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.494"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_3"/>
    <dbReference type="OMA" id="QGVSFIT"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="25008" checksum="887E69B2422249AA" modified="2013-03-06" version="1">MTVFFIGAGIGDADHLTVKAHRLISQADVIIYDALIDNQILQLVPENCLQIPVGKRGGKVSTPQETINQLLAQYAPVYKTIIRLKGGDPGIFGRINPEIETLQAINTDYELIPGISSSIAAPLLANIFLTEKENSHGFMVVTGHDPNLLNWQVLSQVDTLVILMGSKNLPIIVDKLQEYGRSHLFPIAIIKQAGNSQQQIWKGTLGNIVEQTVNISLSPCIIVIGKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L7</accession>
    <name>K9Z2L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219123.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1279"/>
    <dbReference type="EnsemblBacteria" id="AFZ53394">
        <property type="protein sequence ID" value="AFZ53394"/>
        <property type="gene ID" value="Cyan10605_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1279"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905262_0_0_3"/>
    <dbReference type="OrthoDB" id="1902185at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="307" mass="33229" checksum="2B545A1C51CF84C9" modified="2013-03-06" version="1" precursor="true">MNNYQVLSPQHLPLILLTSLWLLTPQKVSAGAIEISIDPYNDSGYETIPLESNQSPNDNTHASPKPNLSVIDKENISSEGIYYVKGNSPPPPPQIVDGNLIQSNQSLPAIPPLNEPYSPQQTADVNPRNITPTNELSVSVSPLNVTPSTENTTSNNAPTTNKIVVENSNNSIRNISVSPQNSNSNSVSVNNNSNNSSMDNLGKRRNLREILVFSNSTNSENIKNNGNNMPSESLQSSSNNSQTVYKVLAKTNGNNQEVGVKSLYPEAFKTNYQGQSLLQVGVFSTQENAEQVSQSLANIGVKAIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M1</accession>
    <name>K9Z2M1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ordered locus">Cyan10605_0845</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218708.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0845"/>
    <dbReference type="EnsemblBacteria" id="AFZ52977">
        <property type="protein sequence ID" value="AFZ52977"/>
        <property type="gene ID" value="Cyan10605_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0845"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.888"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_3"/>
    <dbReference type="OMA" id="LWLDWQI"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="267"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="640" mass="73917" checksum="D64B003495A88873" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P2</accession>
    <name>K9Z2P2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpD</name>
        <name evidence="8" type="ordered locus">Cyan10605_1304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219148.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1304"/>
    <dbReference type="EnsemblBacteria" id="AFZ53419">
        <property type="protein sequence ID" value="AFZ53419"/>
        <property type="gene ID" value="Cyan10605_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1304"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1377"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_3"/>
    <dbReference type="OMA" id="KCFNTLQ"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="6">
        <location>
            <begin position="79"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="113"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="36495" checksum="0B6224836E259EF3" modified="2013-03-06" version="1">MDKDWSDLLKQLLEKQSLTETQAGELMTGWLKEEISPALSGAILTAIQAKGVCAEELAGMARILQNQSLQSEKIDYSEAVIDTCGTGGDGASTFNISTAVAFVASAAGVKVAKHGNRSASSKVGSADVLEYLGIKLNVSDKIAKEALSEVGITFLFAPGWHPAMKSVAPIRKELKIRTIFNLLGPLVNPLYPTGQVIGVYDSQFINPVAEALKLLSINRGVVLHGREKLDEAGLGDITDIALLNEGEITTTTINPQELNLHHESLAALKGGNVEENATILSSVLQGKGTKAQTEVVALNASLALQVAGLIPFGKHLQGIEKCLDIIASGKPWDKLTELVNFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V3</accession>
    <name>K9Z2V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0777"/>
    <dbReference type="EnsemblBacteria" id="AFZ52910">
        <property type="protein sequence ID" value="AFZ52910"/>
        <property type="gene ID" value="Cyan10605_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0777"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.818"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_3"/>
    <dbReference type="OMA" id="NAKAWLF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="23089" checksum="80B95FB518D019CF" modified="2013-03-06" version="1">MSVLADDYPEVADSDLVRNCQQGNKTSFRLLYQRYHHKVRATLYKLCGSEVLDDLQQEVFLKVWKSLPQLRNPKYFSTWLYRICWNVAYDQGSSKKRELQRHQANINQTKQSLEYSLAKSSNNHQELLKLHYQELVARGLQHLSLDHRAVIVLHDLEDLPQQEIAEILSIPLGTVKSRLFKARKNLRQFLELEGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X2</accession>
    <name>K9Z2X2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">Cyan10605_0947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218808.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0947"/>
    <dbReference type="EnsemblBacteria" id="AFZ53077">
        <property type="protein sequence ID" value="AFZ53077"/>
        <property type="gene ID" value="Cyan10605_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0947"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1000"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_0_0_3"/>
    <dbReference type="OMA" id="LYPPQNR"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="335" mass="38570" checksum="C89281A2931BA5C1" modified="2013-03-06" version="1">MTALYLTEPGTKVHYKNQTFTIKKNQTYTCRLSELELLVILPGVQLTDAVISALLDQGIEAIFLRQDGQFRGRLQASFASNPLIRLAQYRTVETSFGLAFAQKFAYGKIRNQRALLQIKNRATKGKIAQLSESIDTINVYQLQLKNIDKPRTRDELMGIEGISARSYYQALQHFFPPHWQFNGRNRRPPKDPINALLSWGYGVLLARIFAVCVKAGLDPYLGFFHSIQPYRPNLVLDLMEEFRPILVDYAVISLIQSQMLDIADFQPSSDGQGIWLSVTAKKLLLRELEERMNQYLLYPPQNRKLKLNQIFLEQARMLARCLLESSLDYEPFFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z343</accession>
    <name>K9Z343_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0875"/>
    <dbReference type="EnsemblBacteria" id="AFZ53005">
        <property type="protein sequence ID" value="AFZ53005"/>
        <property type="gene ID" value="Cyan10605_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0875"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.920"/>
    <dbReference type="eggNOG" id="ENOG50331T6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649332_0_0_3"/>
    <dbReference type="OMA" id="VEPEMYV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="18748" checksum="0946512CC4E05F7F" modified="2013-03-06" version="1">MKSRKTEQIFMELLIQLTAETSHFPVTAVSVLIVGFIAAVGIGSIAWYNSNRVVGWKGEGEKPEQNQNYDKREKSANYDRNITSAETAARIRREGENFKSIPESDASTDTTGGYTVSREGLVNNYAVEPEMYVNQPGDLREKEEAEKVARARELKEVNSDDGDKGVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z344</accession>
    <name>K9Z344_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ordered locus">Cyan10605_0639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218509.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0639"/>
    <dbReference type="EnsemblBacteria" id="AFZ52778">
        <property type="protein sequence ID" value="AFZ52778"/>
        <property type="gene ID" value="Cyan10605_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0639"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.675"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_3"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="218"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="34822" checksum="9491F801EFFD2092" modified="2013-03-06" version="1">MSNPNESFLPIIPVAPPDFKSGFIAIIGRPNVGKSTLMNELVGQKVAITSPVAQTTRNRLRGILTTPSAQIIFVDTPGIHKPHHELGKVLVQNAVSAINNVDLVLFVVDASQPAGGGDRYITDLLLKSKTPVILGLNKSDLQGSKKESLNESYQEICQENWQMINFSAITGEGLDKLQQELINKLDVGPYYYPPDLVTDQPERFIIGELIREQILLHTREEIPHSVAVTVEKVVEETKITKIYAAISVERSSQKGIIIGQKGQMLKTIGTASRQQMQKLLSGKVYLELFVKVEPKWRQSRLRLAEFGYQVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z368</accession>
    <name>K9Z368_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)H-quinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="7">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H dehydrogenase I, chain 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NDH-1, chain 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ndhD</name>
        <name evidence="10" type="ordered locus">Cyan10605_1542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219378.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1542"/>
    <dbReference type="EnsemblBacteria" id="AFZ53651">
        <property type="protein sequence ID" value="AFZ53651"/>
        <property type="gene ID" value="Cyan10605_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1542"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1637"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_0_3"/>
    <dbReference type="OMA" id="RIACSSV"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00491">
        <property type="entry name" value="NDH1_NuoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022997">
        <property type="entry name" value="NADH_Q_OxRdtase_chain4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
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            <end position="25"/>
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        </location>
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        </location>
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            <end position="231"/>
        </location>
    </feature>
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            <end position="263"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="525" mass="57617" checksum="005A20576CDCAB0D" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z378</accession>
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            <fullName evidence="3">Resolvase RNase H domain protein fold protein</fullName>
        </submittedName>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="15234" checksum="BA62048379AD8BEF" modified="2013-03-06" version="1">MIFLGFDPGRDKCGLAIVTIDKQILWHEVIKSEDAIASIQQLWSKYQPNKLIIGNLTTSQEWKQKIIDKLNLSSAIEFVDEKNSTLEARGLYWQMYPPKGLGRLIPQSLKVPPRPIDDLVAILLVERYIDKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">SSU ribosomal protein S1P</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="123"/>
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        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="33544" checksum="2337EA1B9B2F4A28" modified="2013-03-06" version="1">MTANSHSSASNNLSFSMDDFSQALEQEQYDYHFKQGDVVRGKVFEYSSDGVYVDIGGKSPGFVPQTEVDWRGSSNVKEVLPLEQEFDFVIIKEQDAEGQVKLSRRQLFIDQAWDNLKEIEEKGAIVQMLVTGVNRGGVFGEVQGLKGFIPKSHLTQKEDLETLIDQTVDTNILQLDQKENKLVLTQRNIARSSALSQLKENEVVAGKIAKIQPYGVFVDFGGVSGLLHIKQISEGKVNALESFFQIGEEVKVVIMEIDTFKNRISLSTKILETYPGEFLENKEAVMANAEERLANKKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B1</accession>
    <name>K9Z3B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0729"/>
    <dbReference type="EnsemblBacteria" id="AFZ52863">
        <property type="protein sequence ID" value="AFZ52863"/>
        <property type="gene ID" value="Cyan10605_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0729"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="15274" checksum="28DE2622A8FB51A9" modified="2013-03-06" version="1">MSNELYYVQKGMKINYHQNRNINPIIQERLGVSWENIVSFCQHFKIKELALFGSILRDDFSVNSDVDFLITLSSDTNLNWTYFQLMEEELRNMINREIDIIFKENLEKSANWIRKKEILSTAEVIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J8</accession>
    <name>K9Z3J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoVT/AbrB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219041.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1193"/>
    <dbReference type="EnsemblBacteria" id="AFZ53312">
        <property type="protein sequence ID" value="AFZ53312"/>
        <property type="gene ID" value="Cyan10605_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1193"/>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150554_3_0_3"/>
    <dbReference type="OMA" id="DKDEWEW"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10634" checksum="05E7249B48CDE58B" modified="2013-03-06" version="1">MIENTIHTRLVKIGNSQGVRLPKTLLEIAKIKDQIDLSIEDGTIIIRASEENKVRLNWAKSFQEMASENDDQLLDSDTQTLSYWDEQEWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S0</accession>
    <name>K9Z3S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1674"/>
    <dbReference type="EnsemblBacteria" id="AFZ53779">
        <property type="protein sequence ID" value="AFZ53779"/>
        <property type="gene ID" value="Cyan10605_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1674"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1777"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_5_1_3"/>
    <dbReference type="OMA" id="QRQTQII"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="91"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="430" mass="48133" checksum="44C306DED6833FF9" modified="2013-03-06" version="1" precursor="true">MKKSVSPLLQGFIWGGCFTLTAAVSGFVGMTVALKSPLPVNIEPFTEKLQALKRFGLSALFTSPLEQSTNILVMGIDRVPNAEGIDKFTGRSDTMLLVRLEPETHTLKMLSIPRDSRVRLPNGAYTKINGANARGGVPLVKEVIQDNLNGVTVDHYIRVTTDAFKKLVDLVGGVEVYVPVDMQYIDRTQGLYIDLKQGKQVLNGEEAEQFARFRQDNLGDIGRVQRQQILLKALGDKMRSPQMIFKTPQIIDLLQEEIDTDLTSSQIMTLAGFALGLDKKDIRMLMLPGRPSYPREYQLSYWLISEENKQSVIEEYLQIENATPYNRLSPSRIRIAIKNATPNRQLDDKLAELLGENGYRNVYISQKSTIPTTTTQIIVQKGDNESAQQIQRVLNFGELEYSSTGDIDSDITIILGTDAEKLLEENSFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z4</accession>
    <name>K9Z3Z4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219019.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1169"/>
    <dbReference type="EnsemblBacteria" id="AFZ53290">
        <property type="protein sequence ID" value="AFZ53290"/>
        <property type="gene ID" value="Cyan10605_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1169"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914376_0_0_3"/>
    <dbReference type="OrthoDB" id="2218770at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="304" mass="36351" checksum="46772DD13FB5B480" modified="2013-03-06" version="1">MFSKHENKCPICGTQYQINQEKCTVCYWDLGIYLNYKKQSPEKLIKTAEKWARIAFSKIRQYRKERNELRKKMEESPNFTQELFEIKLRLSDIERKLENLSPEQPLSTNIKEELKQEIISEVKAEIREIIQESLKKLPINHISNQDNQFDNSSYTIETEFIENKENYPEKSPNLEKIPNIEINQYEQYILEQYYNNPEFLEQYAYKVNATKKTLEDIYLNKANQIVFQESHQSDYWIVELKNGGYCLLPDLNLKINTNLKAIKTIFELNNYQDNISKNFRVLKTAKVMEINNQWQLTEKGVLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z417</accession>
    <name>K9Z417_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219044.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1196"/>
    <dbReference type="EnsemblBacteria" id="AFZ53315">
        <property type="protein sequence ID" value="AFZ53315"/>
        <property type="gene ID" value="Cyan10605_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1196"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1262"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_3_0_3"/>
    <dbReference type="OMA" id="MRIVSFT"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10804" checksum="BFF85BE8109210E4" modified="2013-03-06" version="1">MFSYEITSPTEARNGLFKLLDKVVEDHQVFIINRRQGENVALIAESDLRSLVETVYLFRNPANSHHLFEALEESMTGKIKPQSLEELKEELGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z437</accession>
    <name>K9Z437_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219069.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1221"/>
    <dbReference type="EnsemblBacteria" id="AFZ53340">
        <property type="protein sequence ID" value="AFZ53340"/>
        <property type="gene ID" value="Cyan10605_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1221"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1288"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_1_3"/>
    <dbReference type="OMA" id="WAMMSIG"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="9"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="548" mass="61011" checksum="82D161BD61BBC957" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z463</accession>
    <name>K9Z463_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdhA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219261.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1421"/>
    <dbReference type="EnsemblBacteria" id="AFZ53532">
        <property type="protein sequence ID" value="AFZ53532"/>
        <property type="gene ID" value="Cyan10605_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1421"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1502"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_1_3"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="38505" checksum="169A4ECADE5103F1" modified="2013-03-06" version="1">MVKERTIPKFDSSKVKINKEESLMYYEDMVLGRMFEDKCAEMYYRGRMFGFVHLYNGQEAVSSGIIKSMRPGEDYVCSTYRDHVHALSSGVPAKEVMAELFGKATGCSKGRGGSMHMFSAEHKLLGGYAFIGEGIPVALGAAYQSMYRRKVLGETDFDQVTACFFGDGTTNNGQFFECLNMAALWKLPILFVVENNKWAIGMAHERAASQTEIYKKASVFNMEGYEVDGMDLLAVRDVAQKAIARARAGEGPTLIETLTYRFRGHSLADPDELRDPAEKEFWNAKDPIIQFGKYITDNKIATREELDAIDKKINALIEEAVEFAESSPEPDGSELYRYVFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z494</accession>
    <name>K9Z494_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219139.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1295"/>
    <dbReference type="EnsemblBacteria" id="AFZ53410">
        <property type="protein sequence ID" value="AFZ53410"/>
        <property type="gene ID" value="Cyan10605_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1295"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1368"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056337_0_0_3"/>
    <dbReference type="OMA" id="PFYPQYF"/>
    <dbReference type="OrthoDB" id="1163028at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="43913" checksum="8E4FB709817496D4" modified="2013-03-06" version="1" precursor="true">MKTISQKMIIGLFFCVFLSLFSEVLLSPFYPLFFSKVFGVQDLSYAGYYIFICRLTVVLFTPIWGFLAKRFEARKLLSVGQLGAAVMTAMMALTQNVYQFTFITVLLLIFKSSYFLLYPLIIELGGEHRRSTLTGVYQAVFHGAIVSSTVVGAWVLNLQHPLHLFYGVALGDVLQFALCFMLLKNIPKLNQQKNIAKNVDSGKNPWGFIIAIGLVVLTFQLANNLVRPYFTAYVTEPTPFGVDLITSSFLFLIPSVMAIASMPFIRRFATSSRLSMLYTTGIMLLIGSLYLQGFSQSLPIFVMARVIYGFFLAITQGVLELKLFENSKSNHLHFNYGLITSFANIGHLGAPLLASSLVNSYGLAFPLIAAATLCILNLALAKLTIFRLKLSEGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C4</accession>
    <name>K9Z4C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219169.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1325"/>
    <dbReference type="EnsemblBacteria" id="AFZ53440">
        <property type="protein sequence ID" value="AFZ53440"/>
        <property type="gene ID" value="Cyan10605_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1325"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1399"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_3"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="3" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="126"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="503" mass="55240" checksum="F4383FE3D168C823" modified="2013-03-06" version="1">MLSSLIWLPIFGAIIVCFLPSFKNTLIYRNIAFIIAIATLIINIIIGSNFDISLFDTQFTESFSWLNWLGLGYDLGVDGLSLPLISLNSLLTLIAIYISPKDIQRPRFYYGMILLLTGGVAGAFLAENLLLFFLFYEVEIVPLYFLIAVWGGAKRGYAAMKFLLYTALSGFLVLISFLGLVWFSGEPTFAFEPLKSHALPVGTQVLLLIPLLIGLFIKIPIFPFHTWLPDAHVEASTPVSVLLAGVLLKLGTYGLLRFGVGFFLEGWLVVAPYLAFLAGISALYGAMCAIAQKDMKKVVAYSSIAHMAYVLLAASATTRLSLQASILQMVSHGLISAMLFILVGIVYKKTGSRDVNYLRGLLNPEKGLPVTGSLMILAVMASCGIPGMVGFISEFLVFRGSFPIFPIPTLLCLIGTGLTAVYFLLMVNRVFFGRLTPELSNLPRVLWSERIPALILAVLIILFGLQPHFISRWSETQASLIFYGGEENVSFVLGSLNTFSHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H7</accession>
    <name>K9Z4H7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219219.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53490">
        <property type="protein sequence ID" value="AFZ53490"/>
        <property type="gene ID" value="Cyan10605_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1377"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1454"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_3_3"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="27447" checksum="D7F49982B79E8E1E" modified="2013-03-06" version="1" precursor="true">MTLFQLFFLVFIFLVTSIIGVVTGSNSLITVPVMLEFGISPTDAIATNMFALIFMSIGGTIPFLKGDILKQRQDIPLLSILTVIGSILGALLVLIIPAETMPLLISVFMIAVLIFSIINKNKGVEKQEKSSPLMEKIGYFLTFLLGVYGGFFSGGYVTTLTATFIGCLNMTFVEAVAITKVLNIFSSLIATAIFMSQGLVDYQLGIILGITMFFGAILGAKWALKMSNLWLKRIFMITVIILAIRNIIGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R2</accession>
    <name>K9Z4R2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219859.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2045"/>
    <dbReference type="EnsemblBacteria" id="AFZ54134">
        <property type="protein sequence ID" value="AFZ54134"/>
        <property type="gene ID" value="Cyan10605_2045"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2045"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2173"/>
    <dbReference type="eggNOG" id="ENOG5030KQZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1737514_0_0_3"/>
    <dbReference type="OMA" id="AIADFEC"/>
    <dbReference type="OrthoDB" id="1929995at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="154" mass="17665" checksum="10AC735F591E369E" modified="2013-03-06" version="1">MFNLQRLCLDTNVYIIGIEDVDSPEAKILKAIGYFGKDNTTIDAEIILSHEVIDQIRRVGKYLWNKDKTGFAISLIWSRLNFHYVDVDFRWRELSSKIVSQGVIPTEDVEIYLTAKLGLCDCFVSSNRGLIKAIADFECLTPSEFVNKYFESIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y4</accession>
    <name>K9Z4Y4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 11">Photosystem II reaction center protein Z</fullName>
            <shortName evidence="10">PSII-Z</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">psbZ</name>
        <name evidence="13" type="ordered locus">Cyan10605_1531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cellular thylakoid membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">Associated with the photosystem II complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the PsbZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219367.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1531"/>
    <dbReference type="EnsemblBacteria" id="AFZ53640">
        <property type="protein sequence ID" value="AFZ53640"/>
        <property type="gene ID" value="Cyan10605_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1531"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1626"/>
    <dbReference type="eggNOG" id="ENOG5032ZB0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195286_1_0_3"/>
    <dbReference type="OMA" id="NWEQSKS"/>
    <dbReference type="OrthoDB" id="2012567at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042549">
        <property type="term" value="P:photosystem II stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00644">
        <property type="entry name" value="PSII_PsbZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002644">
        <property type="entry name" value="PSII_PsbZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036512">
        <property type="entry name" value="PSII_PsbZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34971">
        <property type="entry name" value="PTHR34971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01737">
        <property type="entry name" value="Ycf9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161055">
        <property type="entry name" value="SSF161055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03043">
        <property type="entry name" value="PS_II_psbZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="3 10 11" id="KW-0674">Reaction center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="6860" checksum="F4799DC5C84DD8BB" modified="2013-03-06" version="1" precursor="true">MGVIFQLVLTALVLFSFLMIVYVPVAYASPQNWEQSKPLLYLGSGIWLALVVAVAVLNFFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y9</accession>
    <name>K9Z4Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219961.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54236">
        <property type="protein sequence ID" value="AFZ54236"/>
        <property type="gene ID" value="Cyan10605_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2150"/>
    <dbReference type="eggNOG" id="ENOG502Z7IV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448857_0_0_3"/>
    <dbReference type="OMA" id="LRYYMYW"/>
    <dbReference type="OrthoDB" id="495619at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="600" mass="69365" checksum="2EA32368844BA6EC" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z522</accession>
    <name>K9Z522_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219954.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2142"/>
    <dbReference type="EnsemblBacteria" id="AFZ54229">
        <property type="protein sequence ID" value="AFZ54229"/>
        <property type="gene ID" value="Cyan10605_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2142"/>
    <dbReference type="HOGENOM" id="CLU_1072493_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="29990" checksum="8531BA9C88C98244" modified="2013-03-06" version="1">MFKYNFPFFFLIIIIFEIIKIPVPFISFVKSAKAEKFKSNICDSSQLEANFELKESSIYICTNNEEKQLIQINTNTHEKILSLRAFGSFPTYGATEGNYDDPDSKIYNISPFDFKVIQASIITKIEPVISTQYLPKEVEISILQGLLEENAIASCQPRKPVAVFETEQDNIYICIEEKDNVNAIEMNYLQISKKSQEEINNIPAHLTNNFSYETETKNNKKYVVSYRGLKIYENQKSIEEIPIKNIYLSHPDYTEEDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z526</accession>
    <name>K9Z526_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/lipoate A/B protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219959.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2148"/>
    <dbReference type="EnsemblBacteria" id="AFZ54234">
        <property type="protein sequence ID" value="AFZ54234"/>
        <property type="gene ID" value="Cyan10605_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2148"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2282"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_5_3_3"/>
    <dbReference type="OMA" id="HQGDLTY"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28528" checksum="44BC4556DEF3A681" modified="2013-03-06" version="1">MFLNQKPVWRLIPLFCASGKLQMAIDLWLLKQHKEKNHPPSLRFYTWNPPAISIGVSQKRHIPPHWQNLTYENQPLEIVKRPTGGRGVLHQGDLTYSVVTSYSQGTVTETYEEICQFLILGWKKLGLSLHLGKPKQKYLNSANCFSLATNADLMDDKGNKFIGSAQLRQGKYILQHGSMMLKCDRTTSLGDCTLYEQVFNSSPPQINIPSGLILPKIVNVLVEAAAECFQCRFEIQPLSVEEITEITETILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z595</accession>
    <name>K9Z595_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ordered locus">Cyan10605_2228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220039.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2228"/>
    <dbReference type="EnsemblBacteria" id="AFZ54314">
        <property type="protein sequence ID" value="AFZ54314"/>
        <property type="gene ID" value="Cyan10605_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2228"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2369"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_3"/>
    <dbReference type="OMA" id="QANFYQV"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="77"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="86"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="40301" checksum="6A65E35A39130F37" modified="2013-03-06" version="1">MVNSNSANITESDLIQGTVIASQANFYQVRLDSNESLLCTRPTRLKKIGQSVFVGDRVLVKSTEFERGAIASVLPRETELERPPIANAQQILLVFALEEPTLDPVQLSRFLVKAESTKLKLLLGLNKVDLICPEKQKAWQERLCAWGYEPYFFSVQTSQGVPSLQKVLANKITILAGPSGVGKSSLTSLLIPEIEVRVGEVSGKLQKGRHTTRHVELFELPSGGYIADSPGFNQPHFDFSVESLVNYFPEARARLAENTCKFHNCIHKDEPDCAVKGDWERYPYYLKFLEEAIAFQEATAHKKDEESTVKTKFKANGKKYTEPKLESKKYRRVSRKVSNQKLEDLYNLQNLDSDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A7</accession>
    <name>K9Z5A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chorismate lyase</fullName>
            <ecNumber evidence="1">4.1.3.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.40" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220090.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2282"/>
    <dbReference type="EnsemblBacteria" id="AFZ54366">
        <property type="protein sequence ID" value="AFZ54366"/>
        <property type="gene ID" value="Cyan10605_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2282"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2424"/>
    <dbReference type="eggNOG" id="COG3161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098450_0_0_3"/>
    <dbReference type="OMA" id="AESWWNQ"/>
    <dbReference type="OrthoDB" id="1274776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008813">
        <property type="term" value="F:chorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002800">
        <property type="entry name" value="Rv2949c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01947">
        <property type="entry name" value="DUF98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="22834" checksum="C355298145CF558B" modified="2013-03-06" version="1">MILKTENIVTSWHKLENIWQGGEELVKIGLPHSQLAPPWQILLLGDGSPTRHLRLLTSETIKVDIIDMSLVGNSHDNAPADIEKVPGPRLRRQVWLKTASGKRLAYASSWWEASQVDDYLQNRNLPIWESLSSLHTELYRDIQGIYYGHSQALEEGFGEKGAFWGRHYLFWHARKPLTLIYEVFSPYLTKYLGDMNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F4</accession>
    <name>K9Z5F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2290"/>
    <dbReference type="EnsemblBacteria" id="AFZ54374">
        <property type="protein sequence ID" value="AFZ54374"/>
        <property type="gene ID" value="Cyan10605_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2290"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2432"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109783_0_1_3"/>
    <dbReference type="OMA" id="VCKPVGM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="21945" checksum="82266CA65233E5CF" modified="2013-03-06" version="1" precursor="true">MVLSILCVSLIWFSGGNKILHADTLPNDLGKAVTEIENLDEMRSHLASFLESTPDKPTPDTFKQVCKPVGMKMKQLGEENGWQTKQIAKKYRNPNHAPQNLQEVMALAKFEQDENLKGFWQPEIVDGVKGTKYYRRINVESSCLACHGLKNERPSFVQQKYPQDLAYNFHVGDLRGMYSVFIPEDAIEALKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F6</accession>
    <name>K9Z5F6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219517.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1687"/>
    <dbReference type="EnsemblBacteria" id="AFZ53790">
        <property type="protein sequence ID" value="AFZ53790"/>
        <property type="gene ID" value="Cyan10605_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1687"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1790"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_0_1_3"/>
    <dbReference type="OMA" id="HVCGNIY"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22224" checksum="71397BF830324F0A" modified="2013-03-06" version="1">MSVSPKTVMKWTRADLELLPENDYRYEIIDGELYVTRAPHWKHQICITKIATVLDIWSSQSKLGEAIINPSIIFSDDNNVIPDLIWISHERLKSCVDEAGHFTSVPELVIEVLSQKSNDIKRDKEIKLKLYSNRGVREYWIVDWQLKQVEVYRRVQSQLRLVMTLMEGDSISSALLPDFSCQISEFFSTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I4</accession>
    <name>K9Z5I4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ordered locus">Cyan10605_2363</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220170.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2363"/>
    <dbReference type="EnsemblBacteria" id="AFZ54446">
        <property type="protein sequence ID" value="AFZ54446"/>
        <property type="gene ID" value="Cyan10605_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2363"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2509"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_4_0_3"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="340"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="629"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="724"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="892"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="734"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1180"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="AFZ54446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132310" checksum="95D4DDC23A99ACDF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M5</accession>
    <name>K9Z5M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219597.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1768"/>
    <dbReference type="EnsemblBacteria" id="AFZ53870">
        <property type="protein sequence ID" value="AFZ53870"/>
        <property type="gene ID" value="Cyan10605_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1768"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1876"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_4_2_3"/>
    <dbReference type="OMA" id="MPEMGRM"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10953" checksum="4351590797FCA024" modified="2013-03-06" version="1">MAYRVVWSPKAVEDVEAIAAYIARDSPSYAAAVVQKVIEITDELTQDATKGRLIPEIEESKVMEQFAYSYRLLYRIEGETVTVAALIHGKRLLYLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N9</accession>
    <name>K9Z5N9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M, neutral zinc metallopeptidase, zinc-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219782.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1962"/>
    <dbReference type="EnsemblBacteria" id="AFZ54057">
        <property type="protein sequence ID" value="AFZ54057"/>
        <property type="gene ID" value="Cyan10605_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1962"/>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339403_0_0_3"/>
    <dbReference type="OMA" id="FAQFWYD"/>
    <dbReference type="OrthoDB" id="258121at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="815" mass="96087" checksum="E9036F51C66520B6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P4</accession>
    <name>K9Z5P4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_1788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219617.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1788"/>
    <dbReference type="EnsemblBacteria" id="AFZ53890">
        <property type="protein sequence ID" value="AFZ53890"/>
        <property type="gene ID" value="Cyan10605_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1788"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1896"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_1_3"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ53890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="361" mass="39032" checksum="C37B03B1B9518471" modified="2013-03-06" version="1">MTDIDLLMMNRCIQLAKQAEGKTSPNPLVGAVIVKNGEIVGEGYHPQAGLPHAEVYALKQAGERAKNATVYVNLEPCNHYGKTPPCTEALIGAGVKRVVVGMIDPDERVSGRGIKRLAESGIEVKIGVAEDACLRLNEAFIHRVKTGLPFGVFKYAMTLDGKIATDTGHSQWITGKSARHFVHELRSISSAVIIGGNTLRRDNPLLTTHGLTSHNPLRVVITASFDLPTSAQLWQQDTAKTVVFTTPQPDSSLKDSLLSQGVEIVEIANLNTTMVMENLAKRGCNSVLWECGGNLAKDAIASGNIQKIYCFIAPKIIGGKGLFSPIGDMKIDNMNNALALKNTSIRQIDADFLIEGYLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R0</accession>
    <name>K9Z5R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219435.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1600"/>
    <dbReference type="EnsemblBacteria" id="AFZ53708">
        <property type="protein sequence ID" value="AFZ53708"/>
        <property type="gene ID" value="Cyan10605_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1600"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1699"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063816_1_0_3"/>
    <dbReference type="OMA" id="FMTTHSQ"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="40321" checksum="EC35ED6223F8CC9D" modified="2013-03-06" version="1">MFTNLTVKNFRCFQNLTLNNISRLNLIGGMNNVGKTSLLEAIFLLLGANIPDLSLRINMFRGIEQFTNNYETMWGWLFNNKKIDNIIELIAKNKNETKPEILTINLSSENFSLSPQQNMQDKPKSLSSLTTELIPNKLNLTYKKGDLKVDSSLMVTPDGLITGKREPIYLKPGIFISSKLRSNREDTERFSNLEKKKRQDKIVNILQLLEPRLERLAVLIEGGLPMIAGDIGIGELIPIAYMGEGISRLLSIILAIATTENGVVLIDEIENGLHYSKITDIWKGIDLISRQTNTQIFATTHSFECITSAHQAFNNDSNYDFTYHRLERVNDFIQVFSYDKETINTSVEMNFEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R1</accession>
    <name>K9Z5R1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photosystem II D2 protein</fullName>
            <shortName evidence="13">PSII D2 protein</shortName>
            <ecNumber evidence="13">1.10.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Photosystem Q(A) protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psbD</name>
        <name evidence="16" type="ordered locus">Cyan10605_1808</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2</text>
            <dbReference type="Rhea" id="RHEA:36359"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.10.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="13">The D1/D2 heterodimer binds P680, chlorophylls that are the primary electron donor of PSII, and subsequent electron acceptors. It shares a non-heme iron and each subunit binds pheophytin, quinone, additional chlorophylls, carotenoids and lipids. There is also a Cl(-1) ion associated with D1 and D2, which is required for oxygen evolution. The PSII complex binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cellular thylakoid membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.9" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219637.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1808"/>
    <dbReference type="EnsemblBacteria" id="AFZ53910">
        <property type="protein sequence ID" value="AFZ53910"/>
        <property type="gene ID" value="Cyan10605_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1808"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1918"/>
    <dbReference type="eggNOG" id="ENOG502Z8JK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077965_0_0_3"/>
    <dbReference type="OMA" id="RWFQLGG"/>
    <dbReference type="OrthoDB" id="410807at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010242">
        <property type="term" value="F:oxygen evolving activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01383">
        <property type="entry name" value="PSII_PsbD_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036854">
        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005868">
        <property type="entry name" value="PSII_PsbD/D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PTHR33149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00256">
        <property type="entry name" value="REACTNCENTRE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="SSF81483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01152">
        <property type="entry name" value="psbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="11 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>ChlzD2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>PD2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a plastoquinone</name>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <label>Q(A)</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="351" mass="39428" checksum="8CC868BD6D2A32EC" modified="2013-03-06" version="1">MTIAVGRAPERGWFDVLDDWLKRDRFVFVGWSGILLFPCAYLALGGWLTGTTFVTSWYTHGLASSYLEGANFLTVAVSSPADVFGHSLLFLWGPEAQGDFTRWCQIGGLWTFVALHGAFGLIGFMLRQFEIARLVGIRPYNAIAFSAPIAVFVSVFLMYPLGQSSWFFAPSFGVAGIFRFILFFQGFHNWTLNPFHMMGVAGVLGGALLCAIHGATVENTLFQDGEQANTFRAFEPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLGFNLRAYDFVSQELRAAEDPEFETFYTKNILLNEGLRAWMAPQDQPHERFVFPEEVLPRGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R3</accession>
    <name>K9Z5R3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220254.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2450"/>
    <dbReference type="EnsemblBacteria" id="AFZ54531">
        <property type="protein sequence ID" value="AFZ54531"/>
        <property type="gene ID" value="Cyan10605_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2450"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2595"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_7_3"/>
    <dbReference type="OMA" id="TGKAYNW"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="27941" checksum="A71EEED4F398B5D2" modified="2013-03-06" version="1">MGKNILVIGGNKGIGEGFVHKLMSYSDVEILFVTYRCRETAQNLFNLVDLYPQKIIPLEVDVTQEGAIASSSKTIQSHVDKLHLVINCVGILHEENLFPEKSLKHINSDNLLRYFQVNTIPTALWAKHLMPLFKHSDKTIFAIISAKVGSIEDNRLGGWYGYRASKAALNMLIKNIAIEYNRVVKNTTVVALHPGTTDTNLSKPFQANVSPEKLFSVEKCTQQLLSIINHLTPENNGQFVNWDGNILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z5</accession>
    <name>K9Z5Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2483"/>
    <dbReference type="EnsemblBacteria" id="AFZ54564">
        <property type="protein sequence ID" value="AFZ54564"/>
        <property type="gene ID" value="Cyan10605_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2483"/>
    <dbReference type="eggNOG" id="ENOG5032W26">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133139_0_0_3"/>
    <dbReference type="OMA" id="WINPIVF"/>
    <dbReference type="OrthoDB" id="1786052at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="16684" checksum="AEE8AD428E6B001E" modified="2013-03-06" version="1">MNLTPLIGITTSIFLLSQNPTQDKFNTLKRTLENYNFNVKIEPPPLRSTYGLLQVKNRTIWINPIVFDLQIALPTLIHEATHAAQLCAGKNEITALNLSLSPPNIARPYFTHYNHGLRRHLEAEAYAVQTHPEGYDLVISLLNKHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z608</accession>
    <name>K9Z608_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2541"/>
    <dbReference type="EnsemblBacteria" id="AFZ54621">
        <property type="protein sequence ID" value="AFZ54621"/>
        <property type="gene ID" value="Cyan10605_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2541"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2696"/>
    <dbReference type="eggNOG" id="COG2324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068465_0_0_3"/>
    <dbReference type="OMA" id="FGMPYQN"/>
    <dbReference type="OrthoDB" id="1515153at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33171" checksum="B1FE5206D38BD893" modified="2013-03-06" version="1">MIFGINLREIFTTKAGYFLIGHIVAMAFGLAGLLLVLPHPEFIANLPPIGQSAFSWSMIGGGVIYMILGWSAIAVYAYTQLGLWHWLGFMLPALSISLTSELLGTSTGFPFGAYHYLSGLGYKIAGLVPFTIPLSWFYLGFSSYLITRVGLNRLDIPNWLKDLGAIAFGALLLTSWDFVLDPAMSQTSVPFWQWDQPGEFFGMPYQNFIGWFATGAIFMSVATLIWRVKPLQWEKISLTIPTAVYLGNFGFAMIMSIGAGFYVPIFLGILLGVIPLIIFLRLAYKEETSDNNRQLVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z633</accession>
    <name>K9Z633_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220327.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2523"/>
    <dbReference type="EnsemblBacteria" id="AFZ54604">
        <property type="protein sequence ID" value="AFZ54604"/>
        <property type="gene ID" value="Cyan10605_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2523"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2675"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083538_0_0_3"/>
    <dbReference type="OMA" id="CVITRRA"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="32613" checksum="9A55462676A27AD9" modified="2013-03-06" version="1">MECIVNRRAKFSASHRYWLPELSEAENQQRFGANSRFPGHGHNYVLYVSLIGELDKYGMVQNLSEVKKVIKEEVTSQLDYSYLNDTWAEFQQTLPTTENIAKVIWERLSPHLPLVDIQLYEHPQLWVNYQGNNMEATLTVQTHFSAAHRLALPELSLEENTEIYGKCARVNGHGHNYHLEVSVTGEMDARTGMIVDLGELQKAINDYVVEPFDHTFLNKDIPYFADVVPTAENIAVYIAQLLKDPIASLGVELDKVKLIESPNNSCEIYCRKGVLNQSPANHQVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z634</accession>
    <name>K9Z634_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219585.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1756"/>
    <dbReference type="EnsemblBacteria" id="AFZ53858">
        <property type="protein sequence ID" value="AFZ53858"/>
        <property type="gene ID" value="Cyan10605_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1756"/>
    <dbReference type="eggNOG" id="ENOG5030QVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420172_0_0_3"/>
    <dbReference type="OMA" id="AFDFTQM"/>
    <dbReference type="OrthoDB" id="1432905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="22188" checksum="B41A469388DB6F17" modified="2013-03-06" version="1">MTDFLATFNQIIDKSSSNPSTKNVYEALISAEKYANQNKIKYDFSQLLGSWQLCFITGTKKSQQQRGNFLKNGFYLPAIASIIINYSIPENLQQNKNQGIIENIVKFGLVQFNVSGVCKFINNKNILAFDFLYLKMFILGAKIYETEIRGGKENETTFWDASLKDLAFFRYFLVDENFICARGKGGGLAFWKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A1</accession>
    <name>K9Z6A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation factor SUA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219987.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2176"/>
    <dbReference type="EnsemblBacteria" id="AFZ54262">
        <property type="protein sequence ID" value="AFZ54262"/>
        <property type="gene ID" value="Cyan10605_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2176"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2312"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_3"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="24468" checksum="4264C41B996A6AE0" modified="2013-03-06" version="1">MAILYELNPDNPQSRSIEQIASALKDGAIMLYPTDTVYAIGCDINVKSAVEKVRTLKRLANDKPLTFLCSSLSKISEYAIVTDEAYYIMKRLIPGPYTFLLPATKLVPKLVMSPKRKTTGIRVPDQNVCQAILTTLNNPVISTSAHINDEEGYSPSDDWEKAKLFDYFDKLVDIIIDDYTDPGYQVSTILDFSTENPAVVRQGLGWEELEKWFNFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C7</accession>
    <name>K9Z6C7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ordered locus">Cyan10605_2599</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220397.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2599"/>
    <dbReference type="EnsemblBacteria" id="AFZ54674">
        <property type="protein sequence ID" value="AFZ54674"/>
        <property type="gene ID" value="Cyan10605_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2599"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2760"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_3"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="409"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="717"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ54674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="811" mass="89916" checksum="DD7C0AF3AE4C1147" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G1</accession>
    <name>K9Z6G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220057.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2246"/>
    <dbReference type="EnsemblBacteria" id="AFZ54332">
        <property type="protein sequence ID" value="AFZ54332"/>
        <property type="gene ID" value="Cyan10605_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2246"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2387"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_3"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="4">
        <location>
            <begin position="32"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="36978" checksum="EBB31D1B517AD64C" modified="2013-03-06" version="1" precursor="true">MTDFQIRRRDFLYGLAGLSGSVIASQLPFESASAQAMRLNGAGASFPAPLYQRWFVEYNRINRNVQVNYQSVGSGAGVKQFMGGTVDFGASDVAMKDDEISKVSRGVVLLPVTAGSIVIAYNNKDVSNLKLSRQQLVDVFLGKIKDWKQLGASKSKPIKVIHRSDGSGTTAVFTSHLSAINSEWKSKVGEGKTVQWPGGIGAKGNEGVTATIMQTDGAIGYVEYGFAKNNNLKTAQLQNKAGKYVTPTLENASKTLSQVTLPANLRAFIPDPTGDSSYPIVTYTWILAYKKYSDAKKAEALKNVLKWCVSKTGGQQYSSQLGYVPLPDNVIQKVTQAINTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H2</accession>
    <name>K9Z6H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220442.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2645"/>
    <dbReference type="EnsemblBacteria" id="AFZ54719">
        <property type="protein sequence ID" value="AFZ54719"/>
        <property type="gene ID" value="Cyan10605_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2645"/>
    <dbReference type="eggNOG" id="ENOG502ZC4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968768_0_0_3"/>
    <dbReference type="OrthoDB" id="1560347at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="30897" checksum="7EAF95FD24D2F181" modified="2013-03-06" version="1">MEIQHIKILLKLLGKDNYQGKIGDVKPNTKTNIEQTQKLCYELYNNKLIHLKEKNVTIKINNNGQQVLNNRENRNKLEINILKKCKNREIRISKINIIPASKRDLLIDKLVKENLIDITKKIIHVELTDKGKQYLAEEYLAEGLGHINLTKAVFNNYLNFIRDYFIGKIPPKIKEKITPDDILKTIIRLDRTLNTDNYLPIFHLRNEYKSLLSRDELDSMIFELQKENKISLSRLVDASQYSAEEYDTGIPQSIGYPIFYLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J5</accession>
    <name>K9Z6J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2675"/>
    <dbReference type="EnsemblBacteria" id="AFZ54749">
        <property type="protein sequence ID" value="AFZ54749"/>
        <property type="gene ID" value="Cyan10605_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2675"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2840"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_2_0_3"/>
    <dbReference type="OMA" id="PPYEAFC"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_2" evidence="5">
        <location>
            <begin position="256"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="4">
        <location>
            <begin position="339"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Omp85" evidence="3">
        <location>
            <begin position="429"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="759" mass="83543" checksum="86C136A6DBD27585" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L1</accession>
    <name>K9Z6L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC exporter membrane fusion protein, DevB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2303"/>
    <dbReference type="EnsemblBacteria" id="AFZ54387">
        <property type="protein sequence ID" value="AFZ54387"/>
        <property type="gene ID" value="Cyan10605_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2303"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031364_1_0_3"/>
    <dbReference type="OMA" id="KQWAIAV"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014315">
        <property type="entry name" value="ABC_heterocyst_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02971">
        <property type="entry name" value="heterocyst_DevB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="433" mass="47187" checksum="63DB06425058381A" modified="2013-03-06" version="1">MGEAKISIMEKYGKSITIIATAFGVIMMVGLGLYVVSQRKPNVSSENEISQPVPITSIGGLGRIEPRTEVINVSPSPSLAGARVKTLLVKEGDWLKKGDIIAYTSDYDLKKAELERAKKELTVAQENLNIVKAGAKEGSINAQKAIVSQLQAELQGAIATDRAKINRLQAQLASEREERQATIDRLQAEKNNAQAQLNRYEQLAKEGVISASELDDRQLTLETADKRYQEALAIYRKTISTLSEEINEAQALATQRVNTLNKQIASAQATLNEISEIRPVDVAQAQAQVESAIALVNQAEVDLDLTIIKAPIDGEIIDINAYPGENISSDQGIVEIGNTQEMIVVAEIYESDISKVKLGQETQIRSENNSFDGIITGKITEISSKIGKKDVLETDPAASVDARVVEVKIAINPEDNNKIKNLIYSQVIVNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W8</accession>
    <name>K9Z6W8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">Cyan10605_2817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220606.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2817"/>
    <dbReference type="EnsemblBacteria" id="AFZ54884">
        <property type="protein sequence ID" value="AFZ54884"/>
        <property type="gene ID" value="Cyan10605_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2817"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2994"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_3"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="28046" checksum="4F9597289DBA3201" modified="2013-03-06" version="1">MGNENIVLLSSREIEKMRQVGKLAAQLLDHLEKMVKPGISTYELNEEAEKWTKAHGAKSAPLGYGKPPFPASICTSVNDVICHGIPDKKQILKDGDIINIDVTPILDGYHGDTSRTFFVGTPSPIAKKLVEVTEECMYRGINAVRPGGKIGDIGAAIQEYAESQGFSVVRNFVGHGVGRVFHTPPQIPHYGKKGTGKKLRPGMVFTIEPMINEGTWEAEMGDDGWTAYTKDRKLSAQFEHTVAVTNDGVEILTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z4</accession>
    <name>K9Z6Z4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ordered locus">Cyan10605_2069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219883.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2069"/>
    <dbReference type="EnsemblBacteria" id="AFZ54158">
        <property type="protein sequence ID" value="AFZ54158"/>
        <property type="gene ID" value="Cyan10605_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2069"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2198"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_3"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="329" mass="37932" checksum="9D675EC4E5705162" modified="2013-03-06" version="1">MNKVDYLRISLIDRCNFRCQYCMPEGEELKYLLSSEILSCSELLILLKEVFIPLGFTKFRLTGGEPLLRPDLREIIEEINLLPETQDIALTTNGYLLTEQAQILYDAGLRRINISLDSLNPKNFDLIIGRKNRNFWQKTWLGIQKAYEVGFNPLKLNVVIIPNINDHEILDLAQLTIDKNWHVRFIEFMPIGNEKLFTEKAWIPSEDIREMIRKKWGLEEANILGHGPADVFKIPNSKGTLGFISQMSECFCDRCNRIRLSADGWLRPCLLNETGQINLKNDLRKGITTEEIRKKVADLLLIKPEINFKERNSGTDSGIYKRTMSQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z765</accession>
    <name>K9Z765_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220139.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2331"/>
    <dbReference type="EnsemblBacteria" id="AFZ54415">
        <property type="protein sequence ID" value="AFZ54415"/>
        <property type="gene ID" value="Cyan10605_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2331"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2475"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_0_3"/>
    <dbReference type="OMA" id="EWQANGR"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="26349" checksum="9EA8B2D5CAA4BD3A" modified="2013-03-06" version="1">MFFSDSQFFNNSLPSPDLISCPQGVNTTIHVSAYSTFKRYIDILGGFVGLVITALIFIPIAIAIKWDSQGPVLYSQIRCGLNGKPFRIWKFRSMYSDADQKKHLVENKAKGHIFKNDQDPRITRVGAFLRKTSLDEFPQFWNVLLGDMSLVGTRPPTICEVSHYSSRHWLRLRVKPGITGEWQVNGRSLVDDFEQIVSLDLQYQRKWSIWYDLALIIATVKVVLLRKGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z786</accession>
    <name>K9Z786_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220159.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2351"/>
    <dbReference type="EnsemblBacteria" id="AFZ54435">
        <property type="protein sequence ID" value="AFZ54435"/>
        <property type="gene ID" value="Cyan10605_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2351"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2495"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663455_0_0_3"/>
    <dbReference type="OrthoDB" id="1426043at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASPASE_P20" evidence="2">
        <location>
            <begin position="72"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="414" mass="45754" checksum="B73F4A0FAE4B6D0F" modified="2013-03-06" version="1" precursor="true">MKKFNFIGNFAMMIPTALSMATPYAIASCGLIFGMSNSAFSQDYQISINEKIRESFSLSQQAYLISQRQTSEKRVALVIGNSNYQHGSKLRNAVNDANDVAKSLRDLNFEVILLTNGNLKSMDQSLERFYRELEKGAVGLFYYAGHGIQVNGENYLIPVDARLDRESEVNYETLPLGKLLAAMEETDNNVNIVILDACRDNPFGRSWTRSSNNKGLAAIQNSATGTFIAYATGPGNVAQDGTGRNGTFTEALLKNLKNPNQNVEEIFKQVRIDVANKTDNAQVPWTTSSLIGDFFFSGSQEKPSSNNNQNITRKEENITPPVVEEKKPQPLNNDSVAINNRSNSPFQDLTGANLTPRKISLLRSFIAGYNFKEAPCGSDRHQVTITLSNRYVMCAEGNSKHPSGNFSLEIPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z788</accession>
    <name>K9Z788_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219958.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54233">
        <property type="protein sequence ID" value="AFZ54233"/>
        <property type="gene ID" value="Cyan10605_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2147"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2281"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="YGIAYIR"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="46094" checksum="73D635CA1AD1C1E9" modified="2013-03-06" version="1">MKQRYNYRIHPTSQQEQLLAQLFGCCRVVYNDGVALCQQIYKEGGKKPSNSELQKLLITQAKKTEKREWLSKVSAIPLQQSLNDFNIAYQNFFNSCQGKRKGKKVKPPKFKSRKSNQSARFTRGGFKVGQHKIKLAKIGKVKIIWSRKLPNPPSSATVIKDSASRYFISFVVETIPEKLPDNGQSVGIDLGIETFATLSNGQKIKSSKPLKKYQRKLRRCQRNLSRKKKGSKRDEKARKRVAKVHSKIKDTRTDFLHKLSTDIIRENQTIVLEDLNVSAMVKNRKLSKAISDLGWGTFRTLLEAKSVMYGREFIVIDRWIPTSQVCSNCGFNGGKKELNIREWTCINCGVVHDRDINASKNILVAGGHSETLNGRGAGRKTSIKLAVGDEASTHREIRFKHLSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C8</accession>
    <name>K9Z7C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial nucleoid protein Hbs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2192"/>
    <dbReference type="EnsemblBacteria" id="AFZ54278">
        <property type="protein sequence ID" value="AFZ54278"/>
        <property type="gene ID" value="Cyan10605_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2192"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2329"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_3"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="11451" checksum="91547CABA2203FD8" modified="2013-03-06" version="1">MTIIFNQLGDYFMNKGELVDAVAAKAEVTKKQADSVISATIEAIMEAVSSGDKVTLVGFGSFESRHRKAREGRNPKTGEKMEIPATNVPAFSAGKLFKESVAKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G2</accession>
    <name>K9Z7G2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220238.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2434"/>
    <dbReference type="EnsemblBacteria" id="AFZ54515">
        <property type="protein sequence ID" value="AFZ54515"/>
        <property type="gene ID" value="Cyan10605_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2434"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2578"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_3"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="83"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="319" mass="34075" checksum="831A9010E9458F19" modified="2013-03-06" version="1">MSRSDGNDSYSIGNSPRGVEKKLDISFRWLTLALAITIGVILISIAIIITIGAWPAIKEFNFTFFNNSNWNPVENKYGVIAVVYGTLVSSLIALIIAIPLGVGAAVFLSEDFLPEQIRTILVFLVELLAAIPSVVYGLWGIFVLIPLTKSFGTWLNANFGWFPLFSTPPTGPGMLPAGIILAIMILPIIIAISRDSLASLPPDLRQASLGLGATRWETIFRVLIPAAISGIVGGIMLALGRAMGETMAATMIIGNSNNLNISILAPANTIASLIANQFAEASGLQVSALMYAGLVLMILTLIVNIGAEYIVNQVKARYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I0</accession>
    <name>K9Z7I0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220870.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3098"/>
    <dbReference type="EnsemblBacteria" id="AFZ55151">
        <property type="protein sequence ID" value="AFZ55151"/>
        <property type="gene ID" value="Cyan10605_3098"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3098"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125009_0_0_3"/>
    <dbReference type="OMA" id="GSYKDIQ"/>
    <dbReference type="OrthoDB" id="1435792at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="146" mass="17284" checksum="06C655190546AD7E" modified="2013-03-06" version="1">MSGVSQVNIIESIATLKTLLNEQKTSDNFQKIQVLYLLKSKQVKTITEVAQIVGKHRVTIQWWLRCYQQEGIQKFLRDKKDKNSGGRKSIISDSVIKILTKKLRETPDFKTYKDIQHWLNQEFQIQVSYDVVYYLVRKKLKYCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I5</accession>
    <name>K9Z7I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220875.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3103"/>
    <dbReference type="EnsemblBacteria" id="AFZ55156">
        <property type="protein sequence ID" value="AFZ55156"/>
        <property type="gene ID" value="Cyan10605_3103"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3103"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3307"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055726_0_0_3"/>
    <dbReference type="OMA" id="YYEPHGY"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="27994" checksum="EA9C76FEE8C549C8" modified="2013-03-06" version="1">MQLTWLDSNSWLIEMSNTRILLDPWLVGSLVFGNLKWLLEGKKKTSRPIPDNIDFILLSQGLEDHAHPPTLKVLDHNLPVVASVNAGKVCQDLGYTNITTLKHNESYIFNDKIQIDAIAGSPVGPGVIENGYILRDLVTGESIYYEPHGFHSPNLQKQESITTIITPLTNIKIPFLGPVIKGQETAVEVCRWLNPQYILSTAAGGDIDFDGLLVNLLKPDGTIERLRNLLKEANLFVNVIEPQPGEKIVITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J3</accession>
    <name>K9Z7J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220838.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3062"/>
    <dbReference type="EnsemblBacteria" id="AFZ55119">
        <property type="protein sequence ID" value="AFZ55119"/>
        <property type="gene ID" value="Cyan10605_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3062"/>
    <dbReference type="eggNOG" id="ENOG5032SCR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193673_0_0_3"/>
    <dbReference type="OMA" id="QDFQKWY"/>
    <dbReference type="OrthoDB" id="2052127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="9845" checksum="507D9CB1A2575EA8" modified="2013-03-06" version="1">MPRKPDEYIVHILISNGHREEVRFPSIQEFQKWYSGELVPKADSKDFINVPIKNIQGEYMVVRPSSVVGLRVEPVFFGSVDRNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P5</accession>
    <name>K9Z7P5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220470.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2673"/>
    <dbReference type="EnsemblBacteria" id="AFZ54747">
        <property type="protein sequence ID" value="AFZ54747"/>
        <property type="gene ID" value="Cyan10605_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2673"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737159_0_0_3"/>
    <dbReference type="OMA" id="GYEICAM"/>
    <dbReference type="OrthoDB" id="1401884at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="254"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="44318" checksum="3DEA1A3945BEBEC9" modified="2013-03-06" version="1">MYGNLQEIDVNSLLNFLANQKKTGLLLIEKKYDVFLTPIFYFIFIYQGYIIFAGDENSSTLTRLKQYLTPYELQNNVKFIRDEINKSNSIVEYEGLLILIKYNYLSFEQQKNIANKIIEEVIFQVMNLRQGNFIWQDNFSLQPLNFFFKLEDILPKVIEDLYQWHKLSHYFQSPLQCPIISYSDKEELINQDLSVKFNHKIDGQTSLLQLSRFANKSIINVAELIYPYCQQNLIKMINRYAVNQGEIKKKNYRKVICLSENKNWLQEVEIILEGENYICLNANNLSESLNYIFKTKVDLIIFQLETGNEEAEKLCKVVRSLMEYQTLPIVIVADNFCFQNYLKLKIYGANEYISQKIFQKQGVALIKKYVDDNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q6</accession>
    <name>K9Z7Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220157.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2349"/>
    <dbReference type="EnsemblBacteria" id="AFZ54433">
        <property type="protein sequence ID" value="AFZ54433"/>
        <property type="gene ID" value="Cyan10605_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2349"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2493"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="QMENEAG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="598" mass="68229" checksum="3BD5EE184498CCD3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W3</accession>
    <name>K9Z7W3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220994.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3230"/>
    <dbReference type="EnsemblBacteria" id="AFZ55276">
        <property type="protein sequence ID" value="AFZ55276"/>
        <property type="gene ID" value="Cyan10605_3230"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3230"/>
    <dbReference type="eggNOG" id="ENOG50332RY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176230_1_0_3"/>
    <dbReference type="OMA" id="VPPIWLE"/>
    <dbReference type="OrthoDB" id="1998805at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9547" checksum="EDDE3EFD2AC9C77D" modified="2013-03-06" version="1">MDWKTWEEEEAKVYQPGTPVQLKREGGKIYYVEEYDAMLVPPIWLEDYPKPCYPEELRVVSNLFCVLPQLCLLPQKTLQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z801</accession>
    <name>K9Z801_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220246.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2442"/>
    <dbReference type="EnsemblBacteria" id="AFZ54523">
        <property type="protein sequence ID" value="AFZ54523"/>
        <property type="gene ID" value="Cyan10605_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2442"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2587"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_3"/>
    <dbReference type="OMA" id="CGRFTYY"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="12983" checksum="7850517D39245BB0" modified="2013-03-06" version="1">MKPVPPEVLEQVAEYFNILSNPMRLQILNLLGEGEKCVQELVEATKTSQANVSKHLKIMFQAGIINRRPDGTSAYYYIEDSLIFDLSHLVCNHLADKIEKQALKFRNLPIAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z814</accession>
    <name>K9Z814_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220423.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2625"/>
    <dbReference type="EnsemblBacteria" id="AFZ54700">
        <property type="protein sequence ID" value="AFZ54700"/>
        <property type="gene ID" value="Cyan10605_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2625"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2788"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053995_1_1_3"/>
    <dbReference type="OMA" id="ISTMIWG"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="38074" checksum="6B63FA9E1AF625F0" modified="2013-03-06" version="1">MTPANLQKYLNKLVKNQLHISTMIWGAPGIGKSSIVAQVAQENNLDFIDLRLSQLAPTDLRGLPVAVAGRSKKQGISTWYPPDFLPQDGKGILFLDELNMAPPTMQGVAQQLILDRKVGAYEVPEGWFIWAAGNRKEDRASIFEMPSPLANRFLHLEVTVDFDSFKAYALTNNFHEQIIAFLSYRSELLHKLDIQSHAWASPRTWEMASKLHSNQIDITPAVGEGASAEFNAFVALYQNLPDIDGILKGKGEKIDFPTEASTRYATAIALAIRGKNADEALNSFRWLIDKAGNEWIQLFAVDLMRIMREKGQLGALSKLIKTEKQLQTFFKDFQNIIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z862</accession>
    <name>K9Z862_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220296.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2492"/>
    <dbReference type="EnsemblBacteria" id="AFZ54573">
        <property type="protein sequence ID" value="AFZ54573"/>
        <property type="gene ID" value="Cyan10605_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2492"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2641"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_1_0_3"/>
    <dbReference type="OMA" id="RHNPQFN"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="23726" checksum="D741139571BDBC7D" modified="2013-03-06" version="1">MKIFTIGHSNHSIEKFIDLLKQHQISAIADVRSTPYSRYNQQYNQEKLKHELRRNNISYSFLGKELGARSDNPNCYEENKVVYDKIAQTEEFLKGLKRLKKGLKQYKIALMCAEKDPINCHRAILISRYLKKNKIDIWHILPNGQLESQTELEQRLIAFFELNLSQQLNLFEQNINFTKSEEELIEEAYTLQGEKIAYLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z879</accession>
    <name>K9Z879_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220659.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2871"/>
    <dbReference type="EnsemblBacteria" id="AFZ54937">
        <property type="protein sequence ID" value="AFZ54937"/>
        <property type="gene ID" value="Cyan10605_2871"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2871"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3051"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_3"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="28723" checksum="F0A3244B584102B3" modified="2013-03-06" version="1">MNQPILTVRNLTASVDDTPILKGVNLEIKAGEIHAIMGRNGSGKSTFSKVLTGHPEYEVTGGEIIYQGENLLEKEPEERALAGIFLAFQYPLEIPGVSNLDFLRVAYNARRKHLGLEELDAFDFEDLVEEKLEVVKMNPSFLQRSLNEGFSGGEKKRNEILQMALLEPTLGILDEIDSGLDIDALRIVSEGVNQLRKPDNAFLLITHYQRLLDYITPDFVHVMYEGKIVMSGDKNLALELEAKGYDFLDKEQLTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G0</accession>
    <name>K9Z8G0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho termination factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220592.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2803"/>
    <dbReference type="EnsemblBacteria" id="AFZ54870">
        <property type="protein sequence ID" value="AFZ54870"/>
        <property type="gene ID" value="Cyan10605_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2803"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2980"/>
    <dbReference type="eggNOG" id="COG3330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022760_0_0_3"/>
    <dbReference type="OMA" id="SHSTEWY"/>
    <dbReference type="OrthoDB" id="1681819at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032585">
        <property type="entry name" value="DUF4912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16258">
        <property type="entry name" value="DUF4912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="426" mass="48812" checksum="6FB49C55FBC58D3A" modified="2013-03-06" version="1">MTEQKQTLEEMTLRQLRKIASILNIPRYSRMRKQQLLNIIKTKKNDISPENSNPSNNVDNQAKKSLNRLSPEGKSFLNRRTQENNPPDLTTSSDTFRQNVRLSSLKNLPDNFFFGIDENLGDLPESYGEEKVMLLPLSPQWGYIYWDISPQKQKELRNQGGKFLALRLYDVTDIDYDSETPHNVKEFLCGDVARAWYVPIPVSDRIYAVDIGYRCEDGRWLAIARSPQVKIPSAYPSEWVEDVFVTIPWEEDLKERKQWQLSTTGKSNLVKEKKDLIPVKNSSIPENFKNHSFGSWMLHRGDYSPNIWASGIGLMSGSGAGFSGDLVWNRKFWLIANAELIVYGATDPRAKVIVGDTPISLNPDGTFHFHIPFPDGQIDYPIKAIAPDGEQTRSIHLRFNRDTISENTNKEEEATLEWFTSPQNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L2</accession>
    <name>K9Z8L2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ordered locus">Cyan10605_3007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220786.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3007"/>
    <dbReference type="EnsemblBacteria" id="AFZ55067">
        <property type="protein sequence ID" value="AFZ55067"/>
        <property type="gene ID" value="Cyan10605_3007"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3007"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3204"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033288_0_0_3"/>
    <dbReference type="OMA" id="CPAYAYG"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="531" mass="59580" checksum="693E762E292B6587" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P1</accession>
    <name>K9Z8P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220436.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2639"/>
    <dbReference type="EnsemblBacteria" id="AFZ54713">
        <property type="protein sequence ID" value="AFZ54713"/>
        <property type="gene ID" value="Cyan10605_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2639"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494108_0_0_3"/>
    <dbReference type="OrthoDB" id="5215at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="551" mass="60677" checksum="CB5E7752605D4A29" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R1</accession>
    <name>K9Z8R1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221296.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3548"/>
    <dbReference type="EnsemblBacteria" id="AFZ55581">
        <property type="protein sequence ID" value="AFZ55581"/>
        <property type="gene ID" value="Cyan10605_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3548"/>
    <dbReference type="HOGENOM" id="CLU_2664957_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8752" checksum="7A1D87120D5C96D1" modified="2013-03-06" version="1">MITTNNREETLRLLNLSCAELMEKPNRIYRIAQGQLFLTEGNMTVSINLFDPIEVRHLEKLDTLMINALDIYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R5</accession>
    <name>K9Z8R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221271.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3521"/>
    <dbReference type="EnsemblBacteria" id="AFZ55554">
        <property type="protein sequence ID" value="AFZ55554"/>
        <property type="gene ID" value="Cyan10605_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3521"/>
    <dbReference type="eggNOG" id="ENOG5033DT9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164834_0_0_3"/>
    <dbReference type="OMA" id="ASAINCI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="10932" checksum="5097561483D93DAB" modified="2013-03-06" version="1">MNNRFKGSLVKNIASAFINGLITLSLLLIAPLGLAAVIFNTIAVTISTFLVTMVFDAIAFWLQQSQDPRYLDRPLDGQFQGGITRQNDPNYLDRSDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z977</accession>
    <name>K9Z977_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220665.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z977"/>
    <dbReference type="STRING" id="755178.Cyan10605_2877"/>
    <dbReference type="MEROPS" id="S26.A02"/>
    <dbReference type="EnsemblBacteria" id="AFZ54943">
        <property type="protein sequence ID" value="AFZ54943"/>
        <property type="gene ID" value="Cyan10605_2877"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2877"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3058"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_1_3"/>
    <dbReference type="OMA" id="ACDAYIK"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="23323" checksum="570C5BD6DFE01B8A" modified="2013-03-06" version="1">MTQNFSEQESPNQINSKQNQENPWIEIAKTFAMAAVLSFGIRTFVAEARYIPSSSMEPTLQINDRLIIEKMTYRFRNPERGDVIVFNATEALQAQNFYDAFIKRIIGLPGDTVMVRNGEVIVNGKVLREFYIKEEPEYNYGPVTVPENEYLVLGDNRNNSYDSHYWGFVPDDKIIGRAFVRFWPPQRVGTIDEHPVFAETTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A4</accession>
    <name>K9Z9A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221025.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3261"/>
    <dbReference type="EnsemblBacteria" id="AFZ55307">
        <property type="protein sequence ID" value="AFZ55307"/>
        <property type="gene ID" value="Cyan10605_3261"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3261"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3476"/>
    <dbReference type="eggNOG" id="COG4674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_25_0_3"/>
    <dbReference type="OMA" id="VLCEGTM"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="41986" checksum="C686CA9261466CCB" modified="2013-03-06" version="1">MNETILEIDNLSVSFDGFKALNNLNFKMEKGELRVIIGPNGAGKTTFLDVITGKTQPTEGNVYFKGKNLKKMSEHQIARFGVGRKFQTPRVYLNLTVKENLDLVINRNKNVFSTLFQKANQQDRHSLASLLETIGLTAKANLQAALLSHGEKQRLEIGMLVAQSPDLLLVDEPVAGLTDEETENVGNLLLALAQSHSIIVIEHDMEFVRQIARRVTVLHQGTVLCEGNMNEIQNNPRVIEVYLGEETSLDNNQILWARIAATIGWSDFNLTPKEQDLIINNLSQKFASSPEEEDIFREELRNFLAENIPLADLIPLLETDEEKEQVLELSYQILQDHEMNELENLAYQELLDLLQLPSERVATIINNLKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D9</accession>
    <name>K9Z9D9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">Cyan10605_2946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220727.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2946"/>
    <dbReference type="EnsemblBacteria" id="AFZ55008">
        <property type="protein sequence ID" value="AFZ55008"/>
        <property type="gene ID" value="Cyan10605_2946"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2946"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3135"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_3"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23392" checksum="29785E8A6D414DAC" modified="2013-03-06" version="1">MKQKKINFLESSLNYSLLKSDSDSLIVGVDEVGRGCLFGGVVAAAVAMPLKKIHLLRDIGVNDSKKLTPRKRESLINPIKAVVDCYSIVEVDNITIDQINIFQASLLAMTRAILNLSISPYLCLVDGKFTLPNLSFPQISLIKGDMRSPLIASASILAKVWRDEKMLEYDQRYTNYDLKNNKGYGTKKHLDAIALYGLTPLHRKSFNCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E9</accession>
    <name>K9Z9E9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">Cyan10605_3307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221070.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3307"/>
    <dbReference type="EnsemblBacteria" id="AFZ55352">
        <property type="protein sequence ID" value="AFZ55352"/>
        <property type="gene ID" value="Cyan10605_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3307"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_4_1_3"/>
    <dbReference type="OMA" id="ILLCPCG"/>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13075" checksum="B38174E2C2544894" modified="2013-03-06" version="1">MHELSIMESTLEIAINYAKREKAKSIKQISLKIGELSGVIPSALEFAFDVITKNTIAENAILKIENIPVCCYCQSCEDKFYPPIQYIFECPFCHQLSHHILQGKEIQLSSLEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S7</accession>
    <name>K9Z9S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220847.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3071"/>
    <dbReference type="EnsemblBacteria" id="AFZ55128">
        <property type="protein sequence ID" value="AFZ55128"/>
        <property type="gene ID" value="Cyan10605_3071"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3071"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_6_4_3"/>
    <dbReference type="OMA" id="AEIYNTG"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938669" evidence="1">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="15142" checksum="0FB4FD4B345A8DD4" modified="2013-03-06" version="1" precursor="true">MKKYIAGAIALISTLVVSGYSKAENPAHVQRLLETNLCMGCDLVGANLEGAHLIGADLRNADLRNANLNSANLEGADLDGANLQGADLSNTFLTNATLNNSNLNNVDLSYATIFDAQVQGATMNNMNIENASISETGIAVGGEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Z3</accession>
    <name>K9Z9Z3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221259.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3509"/>
    <dbReference type="EnsemblBacteria" id="AFZ55542">
        <property type="protein sequence ID" value="AFZ55542"/>
        <property type="gene ID" value="Cyan10605_3509"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3509"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023681_0_0_3"/>
    <dbReference type="OMA" id="DFIRWIL"/>
    <dbReference type="OrthoDB" id="1027985at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="476"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="712" mass="82870" checksum="BF7313CA0066D6C1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA69</accession>
    <name>K9ZA69_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220976.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3211"/>
    <dbReference type="EnsemblBacteria" id="AFZ55258">
        <property type="protein sequence ID" value="AFZ55258"/>
        <property type="gene ID" value="Cyan10605_3211"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3211"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3423"/>
    <dbReference type="eggNOG" id="COG3224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075307_1_1_3"/>
    <dbReference type="OMA" id="PVWKINL"/>
    <dbReference type="OrthoDB" id="1695606at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="PTHR40057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="25875" checksum="DBD6BC56224F4CBA" modified="2013-03-06" version="1">MGSSSSQPQVSDQYFEYRFIHRINPSAYNDFLQFQERLRTRAQKYQGYISEDLPVLIEQGETLVFETILRFDTPENCIHWIDSQERRELLSAEENNGYPFQGEGNFESYTRWIKQSINNSSPVWKINLLVLLVLYPTVMLFNLLLKKPSLIDFPTWMLFGNFCSVAITGWFAVPWVSRLYQNWLEGKGTKKEQLLALITIFLALFILLQIFRHIPINFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAA9</accession>
    <name>K9ZAA9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221021.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3257"/>
    <dbReference type="EnsemblBacteria" id="AFZ55303">
        <property type="protein sequence ID" value="AFZ55303"/>
        <property type="gene ID" value="Cyan10605_3257"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3257"/>
    <dbReference type="eggNOG" id="COG3380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036034_0_0_3"/>
    <dbReference type="OMA" id="VCGDWCL"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="346" mass="39602" checksum="D6A6C7DD501D032B" modified="2013-03-06" version="1">MTQKIAVIGAGMAGLTVGKILSKKGFSVDIFDKGRGVGGRMSSRRTEWGYLDHGCQYFTVKDPLFKEFLQEYNSSITVWQGRFFSWIEGHFQEVAEEKSRYLPITSMNTLCKQMALNINICLQTRIVSLHQQEDKWILVDEQSNYYENYDWVIITAPPIQTWDLIKTHRNIIDLVSTETGETGIRGIASIESVQMYPCYSLMLVMAEEKDFGFDGLQLEHPILGWIGVNSSKPARGKQLSLIIQSNFHWAENYLASNQEVLQSDGDSRNLVAEILKKEVEKVLSHNFEGILYESLHLWRYALPKKPNTKKYYIDKSNQLAVCGDWCFQGKVESAFLSAYLLATEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZB12</accession>
    <name>K9ZB12_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221283.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3535"/>
    <dbReference type="EnsemblBacteria" id="AFZ55568">
        <property type="protein sequence ID" value="AFZ55568"/>
        <property type="gene ID" value="Cyan10605_3535"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3535"/>
    <dbReference type="HOGENOM" id="CLU_1632636_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="19036" checksum="E143E5376E7C1627" modified="2013-03-06" version="1">MKLDKIEAIIAIISFIVTLIYSMIKFLVNQLNKKLDSLKDEILLATKDSMNRFMKKNEESRTIFYEKINSNLNKINNEINLIKNNYDHQNILIDTKMAAMNQIFLEQIANVKTQLNELETEHEELKEKINISDEYSHHSNDNFHQKLDNLQKSVDSLSPHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ80</accession>
    <name>K9YZ80_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217973.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0082"/>
    <dbReference type="EnsemblBacteria" id="AFZ52241">
        <property type="protein sequence ID" value="AFZ52241"/>
        <property type="gene ID" value="Cyan10605_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0082"/>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599978_0_0_3"/>
    <dbReference type="OrthoDB" id="2142429at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="18777" checksum="A1057AAF6EC3223D" modified="2013-03-06" version="1">MNNLLKHWLIKYRNREEGFTFLECLVAIIILSMAFAFNGQMVLMLKMQNLKQEIESAAVAVGKDVLDDLRFQLGKNINNVSVTGNTPTTLTDRISFGHTFDADVYVCTDPPTVETDTDNPNQLKVSNCPSGSTDALIRYIVVQVIDKKRDNEKIYTVQTNFAQLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZK8</accession>
    <name>K9YZK8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218081.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0193"/>
    <dbReference type="EnsemblBacteria" id="AFZ52349">
        <property type="protein sequence ID" value="AFZ52349"/>
        <property type="gene ID" value="Cyan10605_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0193"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.203"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078192_1_0_3"/>
    <dbReference type="OMA" id="KNARVYP"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="34102" checksum="1A45D58729657AC6" modified="2013-03-06" version="1">MQSVSPVLTSVPREYLKAPGGFNPNVFMFIIALSLITVSTSGYFLWSFPDWLCFTANVLALHISGTVIHDASHNSAHSNRIINSILGHGSALMLGFAFPVFTRVHLQHHAHVNDPENDPDHFVSTGGPLWMIAARFFYHEIFFFRRRLWKKYELLEWFLSRLFLFTVVFLGIHYGFIGYVMNFWFVPALVVGIALGLFFDYLPHRPFKERDRWKNARVYPGRVLNFLIFGQNYHLIHHLWPSIPWYKYESAYYATKSLLDAKGCDQSLDLLKGKNFGSFLYDIFLGIRFHEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z025</accession>
    <name>K9Z025_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218250.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0374"/>
    <dbReference type="EnsemblBacteria" id="AFZ52519">
        <property type="protein sequence ID" value="AFZ52519"/>
        <property type="gene ID" value="Cyan10605_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0374"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.394"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081497_0_0_3"/>
    <dbReference type="OMA" id="QETDRQI"/>
    <dbReference type="OrthoDB" id="1511177at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="20261" checksum="772BE3E7056794F1" modified="2013-03-06" version="1">MTTTADDVWKILAELAQAQKETERRMQETDRQIARLSKEIGNLGGKWGRFVENMVAPACETIFLNRGIPVHQVSQRVKKKLDGRVLEIDVLGTNENHVLVVEVKSSLGVDNVKELIKDLQKFKEFFPEYNQKQVYGAVAGIEIEEGADKYAYRHGLFVLTQSGENVVIVNGAEFQPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J4</accession>
    <name>K9Z0J4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ordered locus">Cyan10605_0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0532"/>
    <dbReference type="EnsemblBacteria" id="AFZ52674">
        <property type="protein sequence ID" value="AFZ52674"/>
        <property type="gene ID" value="Cyan10605_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0532"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.563"/>
    <dbReference type="eggNOG" id="COG3442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064047_0_0_3"/>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="28675" checksum="F3B9900A82B7E422" modified="2013-03-06" version="1">MSMQLTIGWLYPKLMSTYGDRGNVICLQRRCQWRDLDVSILALDQESSIASFQEFDLIVGGGAQDRQQEIVMRDLQGEKAQIIKEKLTSGIPGVFTCGSPQLLGKYYEPALGQKIEGLGILDLVTKHPGINVPRCIGNVAFDIVAPTLKADLEEMLGEVPTVVGFENHGGRTYLGDVSPLGKVVSGYGNNGEDGYEGAFYQNAIATYAHGPLLPKNPFLADWLIIKAIEHKYQEKISLNPLDDYLADNGRKAMLKRMLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z8</accession>
    <name>K9Z0Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0703"/>
    <dbReference type="EnsemblBacteria" id="AFZ52839">
        <property type="protein sequence ID" value="AFZ52839"/>
        <property type="gene ID" value="Cyan10605_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0703"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.736"/>
    <dbReference type="eggNOG" id="COG5185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026708_0_0_3"/>
    <dbReference type="OMA" id="PWKLRRS"/>
    <dbReference type="OrthoDB" id="1200419at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021437">
        <property type="entry name" value="DUF3086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11285">
        <property type="entry name" value="DUF3086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="429" mass="49630" checksum="E795378015795AA0" modified="2013-03-06" version="1">MSEINKENQNQNFSIDDFDHEDDLWTDQAENNDENLPDLELPLSEDEMNSEIISSNENSKQEEDISQDIYLEELKKESKTEKLTMEESEIKNADIEQKIVASEVKAEIIKANKEENSANQEKSIDEIEQIKRQLIQQQEEISNNINLLVKERLEELENKKQNLEITIEKLERRKERINREMKSSFAGISQDLAIRVQGFKDYLVGSLQDLAAAAEQLELSPPPTQAWENESPPVTPENERGKNSNPQFVEKSFKEETRIIRRLLDQYRTKPDYYGPPWQLRRTFEPIHAERVSDWFFSQGGRGALSSMGSRLQNILIASAIISILYQLYSDRTRVLILADTPEKLGEWRRGLQDCLGISRSDFGPSRGIVLFETPEALVQKGDRIVAQEDLPLVIMDLDDDRVSLSLLKFPLWLAFAPQKMVQSQDYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z105</accession>
    <name>K9Z105_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217967.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0074"/>
    <dbReference type="EnsemblBacteria" id="AFZ52235">
        <property type="protein sequence ID" value="AFZ52235"/>
        <property type="gene ID" value="Cyan10605_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0074"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.76"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038557_2_1_3"/>
    <dbReference type="OMA" id="REYPIEV"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="69"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="46954" checksum="B9171A4B8C55A045" modified="2013-03-06" version="1">MTTTTDRLPKKLITERVENIYAPSEINMWEENRQFSTPNAPKLRILTEFNRERLPAFVETLKKDNYLKIQPFYQRRKRWTNKDKSLLIESFIINIPIPPVIFYEKSYSSYEVIDGQQRINAIQEFYSNKFKLTGLDLWKDLNGYTYESLPSDIRSEINRRSIPIIVVITESAKREEDKFYLTQLAFERLNRGGIDMKPQEIRNCLYHGKFSELLSDLAKNTIFRKAWDLPLDETKLEKNIMYKKMEDIELILRFFALRHLDDFNGDIKRFLDSYMLKALNFNRDDINYLETVFNQTIELCFSIYEENLFKPFDIKNNDWGKKSHKVYYDAIMVAFSFNLDKANIILNKKELIIQKTKEIFYGEKSKLLSSGKTSKSETQERIKIVNDMLIGIVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z132</accession>
    <name>K9Z132_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218174.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0294"/>
    <dbReference type="EnsemblBacteria" id="AFZ52442">
        <property type="protein sequence ID" value="AFZ52442"/>
        <property type="gene ID" value="Cyan10605_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0294"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.305"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278191_0_0_3"/>
    <dbReference type="OrthoDB" id="1595026at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025193">
        <property type="entry name" value="DUF4114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13448">
        <property type="entry name" value="DUF4114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="1">
        <location>
            <begin position="675"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4114" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124631" checksum="7B49587B9824FD1C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z134</accession>
    <name>K9Z134_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218605.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0741"/>
    <dbReference type="EnsemblBacteria" id="AFZ52874">
        <property type="protein sequence ID" value="AFZ52874"/>
        <property type="gene ID" value="Cyan10605_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0741"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.778"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_3_1_3"/>
    <dbReference type="OMA" id="EQMGLNP"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="71" mass="8018" checksum="096B45DA13CE9656" modified="2013-03-06" version="1">MSLSEINIVVNGDTHRCLENQSIPSILQSLGFNIRLIALEYNGEILHRQYWDHTIIREGDRLEVVTIVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z142</accession>
    <name>K9Z142_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218184.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0304"/>
    <dbReference type="EnsemblBacteria" id="AFZ52452">
        <property type="protein sequence ID" value="AFZ52452"/>
        <property type="gene ID" value="Cyan10605_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0304"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.316"/>
    <dbReference type="eggNOG" id="COG4370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035659_0_0_3"/>
    <dbReference type="OMA" id="YPIMDAL"/>
    <dbReference type="OrthoDB" id="368220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019994">
        <property type="entry name" value="CHP03492"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39517">
        <property type="entry name" value="PTHR39517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03492">
        <property type="entry name" value="TIGR03492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="404" mass="45331" checksum="93192CB3788552B7" modified="2013-03-06" version="1">MLSDKNCSQKKILLISNGHGEDLNSSLIGEKLKILNPHFQVDSFPIVGEGKSYLNKNIPIVAPLQQMPSGGIFYLNPINFIKDLTSGLITLTIQQIVTINRIKNNYDFCVAVGDVVPLFFAYLTGKKFVSFLVANSSYYENHLKLPFLTKLILNSNRCLKIFTKDEFTRDDLKKQGFKNVICEGYPIMDTLVSSKNNLPINPQLPMIALLPGSRFPEALNNLILELKVCEILVKKYGGKWQFYTALVSTIKENDLRDLALQIDWKYSQGILKKEINGTEINIHLYYDAFADILLQCNLVIGMAGTAVEQAVGLGKPVVQIPGEGPQFTYRFAEAQMRLLGLNVITVEDNKDIEKKCEQGADKIKEILQNSNFLEKCVKNGKERIGDRGASLKMAHHIEQLVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z146</accession>
    <name>K9Z146_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">Cyan10605_0793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218657.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0793"/>
    <dbReference type="EnsemblBacteria" id="AFZ52926">
        <property type="protein sequence ID" value="AFZ52926"/>
        <property type="gene ID" value="Cyan10605_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0793"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.835"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_0_3"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="23837" checksum="001AC10E0DD0CFD0" modified="2013-03-06" version="1">MRLKICGITNLKQADAIASLGVDTLGFICVKNSPRYINPEQIKTITSKIPSEVSKVGVFVNQSVDDILDIVKTGGLTAIQLHGDETPSMCSTLRESLPDLEIIKVFRYENSDSLAKLDDYLSVIDTILLDTYQKDMYGGTGKTFNWSELADFRPPRPWLLAGGLTPDNVLLALNTLKCDGIDVSSGVETNPGEKDLNKIKLLLEHLNSFKVPLHSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z153</accession>
    <name>K9Z153_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218194.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0314"/>
    <dbReference type="EnsemblBacteria" id="AFZ52462">
        <property type="protein sequence ID" value="AFZ52462"/>
        <property type="gene ID" value="Cyan10605_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0314"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.327"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_4_3"/>
    <dbReference type="OMA" id="VNLHWYY"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="394" mass="45255" checksum="38BEA4E9EF8888AC" modified="2013-03-06" version="1">MQYRRFGRTELQMPVFSCGGMRYQYKWQDLPFIEIPQDNQRNLEATIRKSLEVGINHIETARFYGSSEMQLGKILPTLPREKLIVQTKVPPEEDSKKFLATFEKSLSYLQLDYVDLLGIHGINTPELLEYTIRPGGCLDIARKLQAQGKVRYIGFSTHGATDLIIKTIETNQFDYVNLHWYWIYQKNWDAITSATRHDMGVFIISPSNKGGMLYQPSQKLVDLCQPLSPIIFNNLFCLSHPQIHTLSVGADKPSDFDEHLKTLPLLSQAEELLPPIIERLENEAKRVLGEEWLNTWEKGLPNYEDTPGNINIPMILWLRNLALAYDLVEYGKMRYNLLGNGGHWFPGQKADKLADFDLTNCLKNSPHRDKIPEFLAQTESLLGGQEVKRLSQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z160</accession>
    <name>K9Z160_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M61 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218672.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52941">
        <property type="protein sequence ID" value="AFZ52941"/>
        <property type="gene ID" value="Cyan10605_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0808"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.851"/>
    <dbReference type="eggNOG" id="COG3975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022755_0_0_3"/>
    <dbReference type="OMA" id="EVYAWDL"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00990">
        <property type="entry name" value="PDZ_glycyl_aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039382">
        <property type="entry name" value="M61_PDZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="455"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="575" mass="66976" checksum="9F4DC9515FD582A2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K5</accession>
    <name>K9Z1K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217960.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0067"/>
    <dbReference type="EnsemblBacteria" id="AFZ52228">
        <property type="protein sequence ID" value="AFZ52228"/>
        <property type="gene ID" value="Cyan10605_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0067"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.69"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_4_1_3"/>
    <dbReference type="OMA" id="AYPYFAR"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="688" mass="78361" checksum="2DE7EDF31F92B066" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P3</accession>
    <name>K9Z1P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218857.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0997"/>
    <dbReference type="EnsemblBacteria" id="AFZ53126">
        <property type="protein sequence ID" value="AFZ53126"/>
        <property type="gene ID" value="Cyan10605_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0997"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1054"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_3"/>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114139" checksum="A02105B5A7645983" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P4</accession>
    <name>K9Z1P4_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0354"/>
    <dbReference type="EnsemblBacteria" id="AFZ52500">
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        <property type="gene ID" value="Cyan10605_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0354"/>
    <dbReference type="HOGENOM" id="CLU_1188355_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="27721" checksum="4DE8BAF6B73E9110" modified="2013-03-06" version="1">MMDKKYDPLQPRLNPEIEEILWLIKKNCDELIKEKNFLSRRGQARILIAHLEELVEQPEYFIDVEEGLIDDSRYWMKEGNFTNNSPLFLKEKPFDFAETTENLYFFYSNNKFSLLYKNVPFDPYYCPCLDYGFIVYTLEKLYTTQQETQVHINDNEVITNCLDEIKSSYSQQYLQTDNRYFILIDPLGVNYGLSLTVTTTNNYEEAIFIANSLTDYLPIRFLVAKQIYVFDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q0</accession>
    <name>K9Z1Q0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0360"/>
    <dbReference type="EnsemblBacteria" id="AFZ52505">
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        <property type="gene ID" value="Cyan10605_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0360"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.379"/>
    <dbReference type="eggNOG" id="COG4632">
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    </dbReference>
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    <dbReference type="OMA" id="RGAIAWN"/>
    <dbReference type="OrthoDB" id="1587976at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="457"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="624" mass="68724" checksum="17D8F07336F48961" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S6</accession>
    <name>K9Z1S6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0161"/>
    <dbReference type="EnsemblBacteria" id="AFZ52318">
        <property type="protein sequence ID" value="AFZ52318"/>
        <property type="gene ID" value="Cyan10605_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0161"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.167"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_3"/>
    <dbReference type="OMA" id="FFDVELR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
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    </dbReference>
    <dbReference type="SMART" id="SM00086">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="350"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="434"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="7">
        <location>
            <begin position="576"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="829" mass="95367" checksum="210692C16FE536CE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U3</accession>
    <name>K9Z1U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218075.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0187"/>
    <dbReference type="EnsemblBacteria" id="AFZ52343">
        <property type="protein sequence ID" value="AFZ52343"/>
        <property type="gene ID" value="Cyan10605_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0187"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.196"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_0_3"/>
    <dbReference type="OMA" id="YLYARAE"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="3">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="227"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="48488" checksum="ED15E5F75A8BC90A" modified="2013-03-06" version="1">MSKVKTIAKIAQLLASELEIKKFDIYGSSVDQTSVQVFQGEPKQVKASQKSSVIVRVWNEKEQIGVTSTTDVDEVGIELALKTALEASYFGVTDYVPDFSPSATASLPEVHRELGSQTPASDLIEKLITLETDLLNAHDAIASVPYNGLGEQAIERFYLNSDGALREENRTFTSLYLYAKTEQENKKPRSGGAYKVANSLEKLDIEGCFQETVEKTLSHLDYQPIKSGKYRVVFSPEAFLSLLGAFSNLYNAQNILDKQSLSTPESLGKQIASPLISINDNPLHEGNVSGETFDGEGTPTRNLSIIDKGVLVNFLHSSVTAKRMNAQPTGHASIGAKVSISPNYYHVFRGQSPTTEYSLAEAENVILIDDVQALHAGVNALQGSFSLPFDGWLVNKGEKVSIEAATVAGDFLDLLKSIIFVESEAEVTPSGVCPRIWVDSLSITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W7</accession>
    <name>K9Z1W7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein Cyan10605_0224</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218110.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0224"/>
    <dbReference type="EnsemblBacteria" id="AFZ52378">
        <property type="protein sequence ID" value="AFZ52378"/>
        <property type="gene ID" value="Cyan10605_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0224"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_0_1_3"/>
    <dbReference type="OMA" id="VWISGNQ"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="12463" checksum="2D0A5904A5F2A1F5" modified="2013-03-06" version="1">MAEKKGFGLGLGKMKELANAFQKAQQIQEDAKKLQEELETMQIKGQCENGLVVVTMSGNQEPLKVEIKPEAMGEGAEKLSEMVTEAVRDAYQISTTTMREKMEALTGNLGLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z203</accession>
    <name>K9Z203_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218942.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1088"/>
    <dbReference type="EnsemblBacteria" id="AFZ53211">
        <property type="protein sequence ID" value="AFZ53211"/>
        <property type="gene ID" value="Cyan10605_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1088"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1152"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_3"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="180"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="426" mass="47028" checksum="BC4BA4579FD7E218" modified="2013-03-06" version="1">MSSLFADASLRLEKALQYVTISEDASERLKYPKASLSVSIPVRMDDGSLKIFQGYRVRYDDTRGPGKGGVRYHPSVCLDEVQSLAFWMTFKCALLNLPFGGAKGGITVNPKLLSKAELERLSRGYIEAIADFIGPDVDILAPDVYTNEMIMGWMMDQYSIIRRRISPGVVTGKPLTMGGSQGRDTATATGAFYVINSVLPQFNQKPETTTVAVQGFGNAGAEIAHLLAKSGYKVVAVSDSQGGIYSPHGLDISSIREYKRKHLSIKGVYCHNTVCNIVEHENITNEQLLTLDVDVLIPAALEKQITVENASGVRAKFIFEVANGPITSEADKILEAKGIHVFPDILINAGGVTVSYLEWVQNRNGLYWTLKEVQEKLKEKMIEEAEAVWKIHQELGVSFRTCAYIHGLNRLNMAMSAKGTRDYYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z206</accession>
    <name>K9Z206_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Na-Ca exchanger/integrin-beta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218483.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0613"/>
    <dbReference type="EnsemblBacteria" id="AFZ52752">
        <property type="protein sequence ID" value="AFZ52752"/>
        <property type="gene ID" value="Cyan10605_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0613"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.647"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224714_0_0_3"/>
    <dbReference type="OrthoDB" id="212at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025193">
        <property type="entry name" value="DUF4114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13448">
        <property type="entry name" value="DUF4114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0401">Integrin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="3">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="3">
        <location>
            <begin position="849"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="3">
        <location>
            <begin position="949"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="3">
        <location>
            <begin position="1883"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4114" evidence="4">
        <location>
            <begin position="3471"/>
            <end position="3542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="3546" mass="384966" checksum="7A56DF1C2FD561FA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z237</accession>
    <name>K9Z237_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ordered locus">Cyan10605_1070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218925.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1070"/>
    <dbReference type="EnsemblBacteria" id="AFZ53194">
        <property type="protein sequence ID" value="AFZ53194"/>
        <property type="gene ID" value="Cyan10605_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1070"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1132"/>
    <dbReference type="eggNOG" id="COG1971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096410_3_0_3"/>
    <dbReference type="OMA" id="WHFGLFQ"/>
    <dbReference type="OrthoDB" id="1857762at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20118" checksum="9418CF08D555EF02" modified="2013-03-06" version="1" precursor="true">MSLITIFLTSFGLAMDAFAVSVGSGISLKKVTLKDAIIIGTFFGGFQFFMPLVGWFAGLSFREFIVSFDHWIAFGLLSIIGGKMLYEAWQEEDEEEVGTDFRNLYVLLTLAIATSIDALAIGLGFSVIKTPIITAAVIIGIITFLLSFSGVFLGSKFGHLFEKQAEIIGGFVLIGIGFKILLEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z290</accession>
    <name>K9Z290_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219050.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1202"/>
    <dbReference type="EnsemblBacteria" id="AFZ53321">
        <property type="protein sequence ID" value="AFZ53321"/>
        <property type="gene ID" value="Cyan10605_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1202"/>
    <dbReference type="eggNOG" id="COG4641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372892_0_0_3"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="745" mass="86650" checksum="E66B7E8B2FC8841F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F1</accession>
    <name>K9Z2F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219053.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1205"/>
    <dbReference type="EnsemblBacteria" id="AFZ53324">
        <property type="protein sequence ID" value="AFZ53324"/>
        <property type="gene ID" value="Cyan10605_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1205"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1272"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057477_0_0_3"/>
    <dbReference type="OMA" id="HEVWDYS"/>
    <dbReference type="OrthoDB" id="1032264at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="46902" checksum="E6AD14B413816BAB" modified="2013-03-06" version="1">MKKFAIALIKSKLHHKCLLETQEAIHHTLQDMGFDSVLTDNLERCDRQYIILGVNNLLYPNQIELPPNSIIYNLEQIYPQSPWIQSGYLDYLYQYPIWDYSLSNIAQLRKWGINKVQHLPIGYHPCLTNIPKNDNQDIDVLFYGSINERRQKIIHSLEAKGIKVKALFGVYGEERNSYISRSKIVLNMHFYEAQVFEIVRVSHLLANQIFVISEKSSNSEEENYFQGGLVFCPYENLVSTCLDYLSKDKDRKIIAKNGYHLFKSRSLKDYLNPLINSISQNINNNHKFIKDFYRKNQAKNAFDQGNYQGAIALYEQSLQIDPDCLETNIYLALAFLYNGDDLTAELILYSFIDDKEQNEYELHLVKEKIIKILRQELNKNLQSNNQKLVDNIKVYIKNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G7</accession>
    <name>K9Z2G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219125.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1281"/>
    <dbReference type="EnsemblBacteria" id="AFZ53396">
        <property type="protein sequence ID" value="AFZ53396"/>
        <property type="gene ID" value="Cyan10605_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1281"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_11_3_3"/>
    <dbReference type="OMA" id="QQRFICC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="29878" checksum="C1589FFC9FE73790" modified="2013-03-06" version="1">MDAQELIERYNRGETNFQKVDLQNQKLTNTVLHRINLKEANLSGACFEGCFLTQANLKEANLENVVIQGDLSAVNLIQSQIIKGDLQNSDLTDASLRNANLSHSNFSHSKLICALLHDAILKNVNLSHAILINSLLSRANLTDANLQGANLQGANLTNAIMINTNLENANLSLTQMNSVNGVGIKASHANFSHANLSGGNFANSIFHGANFYHSMMTWCSLKMVDFSEANLSEANLLWSNLTRSNLTKANLVHANISQANFDRADLTEAVMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M8</accession>
    <name>K9Z2M8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219185.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1342"/>
    <dbReference type="EnsemblBacteria" id="AFZ53456">
        <property type="protein sequence ID" value="AFZ53456"/>
        <property type="gene ID" value="Cyan10605_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1342"/>
    <dbReference type="HOGENOM" id="CLU_125438_1_0_3"/>
    <dbReference type="OMA" id="AYHRIAS"/>
    <dbReference type="OrthoDB" id="1943253at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="18141" checksum="06F3655BC795DA56" modified="2013-03-06" version="1">MTDKQQDLKKIHKRIGQIYLMVKQLAEHVGWQGIDNSHMSLDNDLTNLTSQQMDLLNQSSSDSFQPSTFNGREGFSSEHHQLLNNHKDILVDDNSLQTSFSSSYSSVSDNVNISSEEQVNRLTAQLTAAYYRIACLEEQLLAFRNDLAHRDDDFYRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V2</accession>
    <name>K9Z2V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218788.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0927"/>
    <dbReference type="EnsemblBacteria" id="AFZ53057">
        <property type="protein sequence ID" value="AFZ53057"/>
        <property type="gene ID" value="Cyan10605_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0927"/>
    <dbReference type="eggNOG" id="ENOG5032Y1Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163892_1_0_3"/>
    <dbReference type="OMA" id="ISPRYPY"/>
    <dbReference type="OrthoDB" id="2000153at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9632" checksum="659CFACED7427CF5" modified="2013-03-06" version="1">MDENQRDKEKFLFPQSSYRGDFTPENLMFNSNLQEFAQKVSYICNLETNGKIAPQEAYRQIKELWQNLRKSIKNLGINDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V9</accession>
    <name>K9Z2V9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">petE</name>
        <name evidence="14" type="ordered locus">Cyan10605_1435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cellular thylakoid membrane</location>
            <topology evidence="3 12">Peripheral membrane protein</topology>
            <orientation evidence="3 12">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the plastocyanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219275.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1435"/>
    <dbReference type="EnsemblBacteria" id="AFZ53546">
        <property type="protein sequence ID" value="AFZ53546"/>
        <property type="gene ID" value="Cyan10605_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1435"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1516"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_0_1_3"/>
    <dbReference type="OMA" id="YDYYCEP"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04219">
        <property type="entry name" value="Plastocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00566">
        <property type="entry name" value="Cytb6_f_plastocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001235">
        <property type="entry name" value="Copper_blue_Plastocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023511">
        <property type="entry name" value="Plastocyanin_cyanobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00156">
        <property type="entry name" value="COPPERBLUE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02656">
        <property type="entry name" value="cyanin_plasto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0186">Copper</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009016572" description="Plastocyanin" evidence="12">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="13">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13124" checksum="8E5D234F7329A0E4" modified="2013-03-06" version="1" precursor="true">MKKLGLFLSSLLLAVTFMFAAIAPAQADTVEVKMGADSGMLAFQPAKVTIKAGDTVKWVNNKLAPHNVVFDSSVKDADKLSHKGLAFSPGESFEVTFNEPGEYPYYCEPHRGAGMNGTIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X7</accession>
    <name>K9Z2X7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="10" type="ordered locus">Cyan10605_0807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218671.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0807"/>
    <dbReference type="EnsemblBacteria" id="AFZ52940">
        <property type="protein sequence ID" value="AFZ52940"/>
        <property type="gene ID" value="Cyan10605_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0807"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.850"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_3"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="11"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="530"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="852" mass="94595" checksum="F703A86F69ECBFF0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z327</accession>
    <name>K9Z327_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218489.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0619"/>
    <dbReference type="EnsemblBacteria" id="AFZ52758">
        <property type="protein sequence ID" value="AFZ52758"/>
        <property type="gene ID" value="Cyan10605_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0619"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.653"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049570_3_0_3"/>
    <dbReference type="OrthoDB" id="1439298at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="48200" checksum="C2B5D403036D3635" modified="2013-03-06" version="1">MKNKFISYAQNFEDVLLNRIFREQNTGFYVDIGANHPVYDSVTKAFYERGWRGINIEPVPQYYNLLKCDRAEDINLNIGISDEEGELIFCDLVDTGLSTFDQEMAEKLSKEDGFSMEKYTVKVKKLADICHQYIHQPIDFLKVDVEGWEEKVIYSGDWENFRPKVIVIEATIPNSPQRKNTNISNFLHQYNYHHIYFDGLNDFYVAEEFKHWENLFRTPVNVFDQFITYPELEKQKSIAQLQTAINSKDEYINSLKMKKQPSSEQIDNLEKMIKTKDEYINSLEKAIKSKEEDNQNSTNELIKCKQLIREQEKIIKRQYTIHEAEKKDLNHYIQHLQSILSQQQETLKKYNQEHSDIKKNQSLEISNLRKLINDKNAEIEGMKSSKFWKLRKKWFKIKNLINEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A1</accession>
    <name>K9Z3A1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Long-chain acyl-[acyl-carrier-protein] reductase</fullName>
            <shortName evidence="1">AAR</shortName>
            <ecNumber evidence="1">1.2.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADP-dependent reduction of long-chain acyl-ACP to the corresponding fatty aldehyde. Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane, by producing the fatty aldehydes used by aldehyde decarbonylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:12682"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:133243"/>
            <dbReference type="EC" id="1.2.1.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:54176"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:12682"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:133243"/>
            <dbReference type="EC" id="1.2.1.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.80" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218923.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1068"/>
    <dbReference type="EnsemblBacteria" id="AFZ53192">
        <property type="protein sequence ID" value="AFZ53192"/>
        <property type="gene ID" value="Cyan10605_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1068"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1130"/>
    <dbReference type="eggNOG" id="COG5322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801341_0_0_3"/>
    <dbReference type="OMA" id="SWGRNNI"/>
    <dbReference type="OrthoDB" id="586944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016836">
        <property type="entry name" value="AAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026396">
        <property type="entry name" value="UCP026396_short-chain_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04058">
        <property type="entry name" value="AcACP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="38189" checksum="7227AD1A6ABBDB93" modified="2013-03-06" version="1">MFGLIGHLTNLEHAQKEAHKLGYSEYANEGFEFWCSAPPILVDEFQVKSVTGATIEGCYIESCFLPEMLNSRRIKTAIRKILNAMALAQKHNINITALGGFSSIIFEEFNLKENKQVRNVELEFERFTTGNTHTAYIICRQVEQASAQLGIDLSKATVAVCGATGDIGSAVCRWLNQKTDVADLLLIARNRERLELLQSDLGRGKIMGLEEALPLADIVVWVASMPRGVEINNETLKKPCLLIDGGYPKNLGTKFNHPDIKVLNGGIVEHSLNIDWKIMEIVNMDIPGRQMFACFAEAMLLEFEKWHTNFSWGRNQISVEKMEQIGEASVKHGFKPLLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G8</accession>
    <name>K9Z3G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1629"/>
    <dbReference type="EnsemblBacteria" id="AFZ53736">
        <property type="protein sequence ID" value="AFZ53736"/>
        <property type="gene ID" value="Cyan10605_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1629"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1729"/>
    <dbReference type="eggNOG" id="ENOG502Z91K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075508_0_0_3"/>
    <dbReference type="OMA" id="QITAIYL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="283" mass="33316" checksum="B1164D8A33E2A976" modified="2013-03-06" version="1" precursor="true">MFIILVLYHKIRHKINQKLIISNRKLLLMLKKFIYLLIVIISILVTNINPIFALSLEDRINQYPSWQQKILLPKPEKDLIFPDWFEGKWEVTSILKEQIAPLAPKFQTPGFEQNNEYIDKKIQFSVKFIESSFYPQQDNFVPQKINKQIIIIADRKFNSLSIAQAYLGIDNVEKVVINPNNTTEQITKFRGENELISTVIGRQQENISEKDFITSEVTRQFFRRPNSVYLNLVETTTKYHLINSNLIKAKQFTAIYLSPQDPDYFVAFDQPVALYYYTLELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H3</accession>
    <name>K9Z3H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219401.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1565"/>
    <dbReference type="EnsemblBacteria" id="AFZ53674">
        <property type="protein sequence ID" value="AFZ53674"/>
        <property type="gene ID" value="Cyan10605_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1565"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1662"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035286_1_0_3"/>
    <dbReference type="OMA" id="VQMPEGE"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="445" mass="50456" checksum="3C896819399DF901" modified="2013-03-06" version="1">MSTRVIIARHGQSSYNAQKMIQGRCDESVITEKGEKQAQLLGEALKDVKLGAFYSSPLQRAYKTAQIVQSLNQYKPSITVMEKLREINLPEWEKWKKEDVKREFPEAYRTWKEKPDELKMTFEGEEFYPVLDLYQQAQEFWQEIIPKHDGETILITAHNGINRCLILTALGMSPAYYHCLQQSNCCVNVLNFTGNFGDSVQLESLNQIGHLGTPLPDFRPEQKQGLRLLLVRHGETEWNRMSRFQGVKDIPLNDNGRQQAEKAAEFLKDVQIDFAVTSPLSRPKETAEIILKHHPDVNLTTKKDLEEISHGLWEGKLETEIEAEFPGLLAQWKAKPETVQMPEGENLQQVWDRAIASWQEIVKENIEEGKMKTGLVAAHDAINKVIICYLLGLESANFWNIKQGNGAVTVVDYPYGLNGKPILQAINLTNHLSGGLFDKTAAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J5</accession>
    <name>K9Z3J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218891.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1034"/>
    <dbReference type="EnsemblBacteria" id="AFZ53160">
        <property type="protein sequence ID" value="AFZ53160"/>
        <property type="gene ID" value="Cyan10605_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1034"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1096"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_1_2_3"/>
    <dbReference type="OMA" id="QKMQFVL"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="30661" checksum="D4B901A41AE8110C" modified="2013-03-06" version="1">MDRQTTGNISTLIGGILAALIVFIGFNSFIIINPGQAGVLSILGKAQDGALLEGIHFKPPLVSNVDVYDVTVQKFEVPAQSSTKDLQELSASFAINFRLDPIQVVNIRRTQGTLQNIVAKIIAPQTQESFKIAAARRTVEEAITQRNQLKDDFDNALNERLEKYGIIVLDTSVVDLNFSPEFAKAVEEKQIAEQKSQRAVYVAKEAEQQAQADINRAKGKAEAQRLLAETLKAQGGDLVLKKEAIEAWKEGGAQMPKVLVMGGDSNGGGIPFLFNLNELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K5</accession>
    <name>K9Z3K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219051.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1203"/>
    <dbReference type="EnsemblBacteria" id="AFZ53322">
        <property type="protein sequence ID" value="AFZ53322"/>
        <property type="gene ID" value="Cyan10605_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1203"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1269"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622297_0_0_3"/>
    <dbReference type="OMA" id="DFWCGHP"/>
    <dbReference type="OrthoDB" id="401909at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="52167" checksum="B1D45ECB23AD4D8A" modified="2013-03-06" version="1">MNQKTTILLQEQYDNLPYPQIPIEQSPEEYYDTLFIHDLTTPYYLSQQKIIDTKDKVILDAGCGSGWTSLFLAYANPGAKIIGIDLSPKSVEVAKTRLNHHGFTNSEFYTLSIEDIDKLNYRFDYINCDEVIYLLPDAEKVLKLFQSLLNEQGIIRVNFHSYYQRFNFFRLQKLFKNMGLMDSNPDDLEVELVKETFNSLNDSVAAKQLWKNKFASMAFPPQKQKQSILVNYLLQGDKGFTIPQVFEMLKSSHLSFLSMVMWRKWNIRDLFQNPDSLPDIWELGLGEVSQEEELSLYELLNPIHRLIDFWCVNDNIQSSINPVINWDKKDWETAKISLHPRLRYKKIKEDLLKAIRTKQSFLFNRYISFPAKGNIDIESDIASCLIILWEKDSVTLEELVKRWLIIQPNDLVSLQPKAMEVAYDELINVIVRLENFLYILVEKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N0</accession>
    <name>K9Z3N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S metabolism associated SufE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218724.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0861"/>
    <dbReference type="EnsemblBacteria" id="AFZ52993">
        <property type="protein sequence ID" value="AFZ52993"/>
        <property type="gene ID" value="Cyan10605_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0861"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.905"/>
    <dbReference type="eggNOG" id="COG2166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124502_0_1_3"/>
    <dbReference type="OMA" id="DWMQRYE"/>
    <dbReference type="OrthoDB" id="1996347at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="3">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16103" checksum="68F24D4D3B22ACE5" modified="2013-03-06" version="1">MSSNTHSRPEKLDKIVQKFKRRDNPKQKYEQLLWYAQKLEPMPETEKTPENKVSGCVSQVYITSTLDQGKIFYQGDSDAQLVKGLVAFLIAGLNGLTPQEIITLTPDFIEETGLQVSLTPSRANGFINIFKKMQQQAIFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U3</accession>
    <name>K9Z3U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218784.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0923"/>
    <dbReference type="EnsemblBacteria" id="AFZ53053">
        <property type="protein sequence ID" value="AFZ53053"/>
        <property type="gene ID" value="Cyan10605_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0923"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.970"/>
    <dbReference type="eggNOG" id="COG3565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109157_0_1_3"/>
    <dbReference type="OMA" id="FFLEDPF"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16869" checksum="7986C81A563EF5BE" modified="2013-03-06" version="1">MNKYLFHLAIPINDIDTAKKFYGDILGCDIGRENQHAVIFNFYGHQLVGHTTKETLVPPSSIYPRHFGIIFTEESHWSDLLNRCQEKYLQLYQQPKLRFKGEITEHKTFFLQDPFYNILEMKFYRHYEAIFGANDFLTIGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z492</accession>
    <name>K9Z492_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219736.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1913"/>
    <dbReference type="EnsemblBacteria" id="AFZ54011">
        <property type="protein sequence ID" value="AFZ54011"/>
        <property type="gene ID" value="Cyan10605_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1913"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2030"/>
    <dbReference type="eggNOG" id="COG1836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_0_1_3"/>
    <dbReference type="OMA" id="AYGKRTF"/>
    <dbReference type="OrthoDB" id="737126at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00297">
        <property type="entry name" value="TIGR00297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="253" mass="27260" checksum="D2689175B9843C7E" modified="2013-03-06" version="1">MNIINVILQNPWLLGITINTILLAIALLLPKKLLTVMGYLNAWILGVVVWGCLQWQGYLVVMFYFLVGSAITKVGMAQKMAEGIAEKREGVRSVENVWGSALIAFICALGYGFTDSGDDFFLIAYVASFATKLSDTCASEIGKAYGKRTFLITTLQPVARGTEGAISLEGTITGIIASGAIALLGYLTNLINPIGIVICLISAFIATNLESVIGATLQEKIDWLTNEIVNIINTFLGAVIATMLLLLYHVTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z493</accession>
    <name>K9Z493_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper-resistance protein, CopA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218909.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1052"/>
    <dbReference type="EnsemblBacteria" id="AFZ53178">
        <property type="protein sequence ID" value="AFZ53178"/>
        <property type="gene ID" value="Cyan10605_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1052"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1113"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_5_2_3"/>
    <dbReference type="OMA" id="WNQMRMS"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13848">
        <property type="entry name" value="CuRO_1_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13874">
        <property type="entry name" value="CuRO_2_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006376">
        <property type="entry name" value="Cu-R_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034284">
        <property type="entry name" value="CuRO_1_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034282">
        <property type="entry name" value="CuRO_2_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01480">
        <property type="entry name" value="copper_res_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="171"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="500"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="616" mass="70006" checksum="85E43CDEC4D2DB07" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G4</accession>
    <name>K9Z4G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1981"/>
    <dbReference type="EnsemblBacteria" id="AFZ54076">
        <property type="protein sequence ID" value="AFZ54076"/>
        <property type="gene ID" value="Cyan10605_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1981"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2102"/>
    <dbReference type="eggNOG" id="ENOG503153R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451495_0_0_3"/>
    <dbReference type="OMA" id="CYELPVH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="22116" checksum="FD63A43EE94C53C3" modified="2013-03-06" version="1">MMNSSLINWQKLAEIKELKDYFNDDFQEFKNSICHYLKIMAKMTSTSIQEIAIIRALEVTNGCTQHSYRRNDSDSLSVEQTRECMKLSISSIRNQEIILKNGDVLEFSPETKELMTHIRTLYMDAFKNNIASQEKEFYAFSTAQFLACGKEKIDYGFQVVKDNYQDLFTDTFINKGIKYIEKYLEAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G9</accession>
    <name>K9Z4G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219002.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1151"/>
    <dbReference type="EnsemblBacteria" id="AFZ53273">
        <property type="protein sequence ID" value="AFZ53273"/>
        <property type="gene ID" value="Cyan10605_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1151"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1218"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_3"/>
    <dbReference type="OMA" id="LMREVWD"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="26665" checksum="DAA767AF5A7FC51A" modified="2013-03-06" version="1">MRVLLIEDEKDLGIAIKRSLLGQNYVVDWVKSGQEGLDLLENSNISYNVGVFDWLLPELSGIELLKIIRKKNNPLPVLMLTAKDAMENKIQGLDAGADDYLIKPFDMLELFARIRALLRRSQEIKPSQLRVKNLILDYQTNTIQITLKTDKIKIIPLTKKEFHLLEFFMRHPQQILTRDQILDQLWEIGSDTISNVVAAQIRLLRKKLNQYGYGDLIETVYGLGYRLKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L3</accession>
    <name>K9Z4L3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein PatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls heterocyst pattern formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nitrogen starvation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219804.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1984"/>
    <dbReference type="EnsemblBacteria" id="AFZ54079">
        <property type="protein sequence ID" value="AFZ54079"/>
        <property type="gene ID" value="Cyan10605_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1984"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031371_1_0_3"/>
    <dbReference type="OMA" id="NGKNIEY"/>
    <dbReference type="OrthoDB" id="1401884at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043158">
        <property type="term" value="P:heterocyst differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024186">
        <property type="entry name" value="Sig_transdc_resp-reg_PatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005897">
        <property type="entry name" value="RR_PatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0364">Heterocyst</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="258"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="43019" checksum="03909AF2FE68DA46" modified="2013-03-06" version="1">MIATMTRKTVTSPNVKEIVAIPYKALQGLLAKKVSGKLMIQDPNDESVRWLIYLGEGKIHYAHSINGKRERIRYLLSRCYPDHGFYIPQELEDDYGFICQHWRDGDLDMQKIRTILSYMTQEAIALCLALPRATISFEKIVGLDPLILNLSLKSLIEPVKSKVRGWVTLRECISSPFVRPRVNNWDILKTHFGNRMSEYQEVEQLKPYLDDRRTLYDIAAYSRHSVLDLALLLHPLIKSDIITISPFQEPTETEDKPLIACIDDSQAIQRIVKMTLIAGGFDVVSITEPAKAMSSFVRQKPDLILMDINMPDIDGYKLAYMLRQSALLKDIPILMLTGRDGVLDRVKAKMVGAVGYISKPFNPQELVQSIQDNIQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q3</accession>
    <name>K9Z4Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b6-f complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b6-f complex subunit PetN</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b6-f complex subunit VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">petN</name>
        <name evidence="12" type="ordered locus">Cyan10605_2072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cellular thylakoid membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PetN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219886.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2072"/>
    <dbReference type="EnsemblBacteria" id="AFZ54161">
        <property type="protein sequence ID" value="AFZ54161"/>
        <property type="gene ID" value="Cyan10605_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2072"/>
    <dbReference type="HOGENOM" id="CLU_215774_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009512">
        <property type="term" value="C:cytochrome b6f complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00395">
        <property type="entry name" value="Cytb6_f_PetN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036143">
        <property type="entry name" value="Cytochr_b6-f_cplx_su8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005497">
        <property type="entry name" value="Cytochrome_b6-f_cplx_su8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03742">
        <property type="entry name" value="PetN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103451">
        <property type="entry name" value="SSF103451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="29" mass="3298" checksum="891932F803B695A1" modified="2013-03-06" version="1">MDILTLGWVGILSLFTWSIAMVVWGRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q4</accession>
    <name>K9Z4Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219849.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2033"/>
    <dbReference type="EnsemblBacteria" id="AFZ54124">
        <property type="protein sequence ID" value="AFZ54124"/>
        <property type="gene ID" value="Cyan10605_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2033"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2160"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045508_0_0_3"/>
    <dbReference type="OMA" id="AACRECN"/>
    <dbReference type="OrthoDB" id="1567761at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="300"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="475" mass="52383" checksum="82F5EFC4052EA056" modified="2013-03-06" version="1">MTYSVTCIEQRQQEIKKTRKLLAIGVLGSIALHGIMFRVLNSIEKPLTEETKPIEFIVVQEPEVKPEEKPQPEEKPQPKLETVKPPLPQTREVPPQPTVNKRETKPNPPMQEVARVNPTPQPQKTSEAIENNPKPEQITETTPQPSITPSPESPISPSQEVLTSNAPVKNNIPRAVKPINDNSNSLSSSLNSSPRAESRNNGQSSTVARVTQDTPVSSGRLSRSSNNTPSAVSSSQGEEVGNLRNSLSRGSSQTSNNNSQNTVSGIPSNIAATSQSVPSRPQAKPTPPPPESIKCISNCNPEYPSALQGVEGKATVKVNLDSNGNVLGVSVVGSHSNGEVNRQALLAARKMRFSSPGVNNASVQVSINFTVAGSEFDRIARQKKEAAERQARLEQEKERQARQAQLEKERLERQRQLEKERQEREAQARIEREKREEELRKQQELEQNQQETLPSETPTKETNLEENDSDNPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R8</accession>
    <name>K9Z4R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219309.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1469"/>
    <dbReference type="EnsemblBacteria" id="AFZ53580">
        <property type="protein sequence ID" value="AFZ53580"/>
        <property type="gene ID" value="Cyan10605_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1469"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_0_2_3"/>
    <dbReference type="OMA" id="NIEFAFP"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="352" mass="40147" checksum="C986F75E45F189C7" modified="2013-03-06" version="1">MLDFFINLSEKLPSLVKDIIISIFLLVLGYFFLRVAKNIVVRQLKKISKDNQNLLAYKITNILAKHFLPITYFGLFYLTIKEIQLHRSILGAVKTFSIIATTFCVGRLLVDISKILIEYYGQKYHDSNKEIERKINALFPALRVVIWTLATIFILSNLGFDIGAIVAGLGIGGVALALASQGILQDLFSYFAILFDRPFEISDLVAIDDYIGYVEHIGIKTTRIKALTGEQLILANTDLTNSRLRNFKRMQRRQVILKIGVVYETENAVLETIPDIIKEALIGIKNVTFDIAFFSGFGNFSLNFDIIYYVHSNELYISRMAQNEVNFAIKKAFYHHKIIFAYPTQTLYVNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T5</accession>
    <name>K9Z4T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-terminal processing peptidase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219152.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1308"/>
    <dbReference type="MEROPS" id="S41.009"/>
    <dbReference type="EnsemblBacteria" id="AFZ53423">
        <property type="protein sequence ID" value="AFZ53423"/>
        <property type="gene ID" value="Cyan10605_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1308"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1381"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_0_0_3"/>
    <dbReference type="OMA" id="NHQDWDM"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="437" mass="47994" checksum="77E32F06039AF48C" modified="2013-03-06" version="1" precursor="true">MNQSGNESSRKKHPLLKSFLASFAIGGFLTSSIPLQARAEMVDSPKVVVDEVWQIINHEFVDRNFNRIDWIKKREELLEKNYSSKKQAYRAINQALKELGDPYTRFLPPEQFETLTSQTSGEVSGVGIRIAIDPRTQDLYIIETIRQSPAEEAGLQRGDRIVRIDGKPTALMDLDQASEALKGELGTDVNLEIARRGKPAFNVSVTRAQFEVPSVDFAMKREGELNIGYIKLEEFSSHAAEQMQKAIRELNQQKAQGFVLDLRGNPGGLLFASVDIARMWMSQGEIVDIVDRQGGHQTFSADNSAITDLPLVVLVDGDSASASEILAGALKENSRATIVGTNTFGKGTVQSVHSLSDGSGLAVTISRYYPPSGTNINKKGIAPDIVQALTREEQYLLSQDPSLIATKADSQYSKAIAILRTVGKLNHNNNSYGSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y5</accession>
    <name>K9Z4Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219914.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2100"/>
    <dbReference type="EnsemblBacteria" id="AFZ54189">
        <property type="protein sequence ID" value="AFZ54189"/>
        <property type="gene ID" value="Cyan10605_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2100"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2232"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_5_1_3"/>
    <dbReference type="OMA" id="APFIAQF"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="49"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="35445" checksum="9CA63C5B84CEADCA" modified="2013-03-06" version="1">MTKKYDVYGMGNALMDMEFSVTPELLAQLNIDKGVMTLMDETQQKEVLTHLPNPCKQSSGGSAANTLVAISQLGGKGFYSCKVAADEVGKAYLEDLVNCGLDTNLALDNRPEGITGKCLVLVTPDADRTMNTFLGITSDLGLTEIDDEALKDSQYLYIEGYLVSSPVAKATAIHGKKVAESAGVKTSFSLSDANMVDFFRDGILEIIGDGVDLLFSNEIEALKMANTDKLEDAIAFLQTLAKTFTITRGKEGSLIFDGEKIIEIEPYPVNAVDTVGAGDMYAGCLLYGITNGLGWEKAGKLASLASSKLVTSFGARLDTSVLQSLLEQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z8</accession>
    <name>K9Z4Z8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate kinase</fullName>
            <ecNumber evidence="6">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_2110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219924.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2110"/>
    <dbReference type="EnsemblBacteria" id="AFZ54199">
        <property type="protein sequence ID" value="AFZ54199"/>
        <property type="gene ID" value="Cyan10605_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2110"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2243"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_3"/>
    <dbReference type="OMA" id="IIQSQRC"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="446"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="602" mass="63767" checksum="4EA63BF1FD70750B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z512</accession>
    <name>K9Z512_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219939.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2126"/>
    <dbReference type="EnsemblBacteria" id="AFZ54214">
        <property type="protein sequence ID" value="AFZ54214"/>
        <property type="gene ID" value="Cyan10605_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2126"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2262"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_1_0_3"/>
    <dbReference type="OMA" id="RVFTFSM"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="33632" checksum="D835929AA5FF33FF" modified="2013-03-06" version="1">MNLPVVYHSDYVTPLPEQHRFPMPKFKLLYELLLKDQIITQESTYKPTIANDKLLQLVHNETYVSQFCDGTLDDKSKRRIGLPWSEGLVKRTCTAVGGTILTVQLALEHGICCNLAGGTHHAFPDYGSGFCIFNDIAIASRYLLIEKIVNKILIIDLDVHQGDGTAFIFRDDERVFTFSMHCEANFPYRKQKSDLDIPLPIGLDDDGYLQILAFHLTDLLKQVKPDIVIYDAGVDVSGCDRLGKLSLTDTGIYRREMMVLSTCLAEGYPVAGVIGGGYCKDLDELVYRHSLIHRAAAECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z531</accession>
    <name>K9Z531_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220011.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2200"/>
    <dbReference type="EnsemblBacteria" id="AFZ54286">
        <property type="protein sequence ID" value="AFZ54286"/>
        <property type="gene ID" value="Cyan10605_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2200"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2338"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_3_0_3"/>
    <dbReference type="OMA" id="PTHRARW"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="26435" checksum="D6ADDB06CD07AF30" modified="2013-03-06" version="1">MVTKTESPITKNENQHIIKSEISPWLIRLVYPLANRIIFPFFFKNIHIEGKENVPKSGAVIIAPTHRSRWDALIVPYATGRMVTNRDPFFMVSANEMKGFQGWFIRRLGGFPVDTERPGLESLYHSGKLLSEGKMVVIFPEGNIYRTVNTVNPLKRGIAKIALEVEASNPEVEVKILPVAIKYSEVIPSRGCSVNVKIGSCLRVNEYLNGSIRENSIRLTADLKTSLQNELNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z539</accession>
    <name>K9Z539_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromophore lyase CpcT/CpeT</fullName>
            <ecNumber evidence="3">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpcT</name>
        <name evidence="4" type="ordered locus">Cyan10605_2163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CpcT/CpeT biliprotein lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219974.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2163"/>
    <dbReference type="EnsemblBacteria" id="AFZ54249">
        <property type="protein sequence ID" value="AFZ54249"/>
        <property type="gene ID" value="Cyan10605_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2163"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2298"/>
    <dbReference type="eggNOG" id="ENOG502Z877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092589_0_0_3"/>
    <dbReference type="OMA" id="NPPFFAH"/>
    <dbReference type="OrthoDB" id="1217830at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017009">
        <property type="term" value="P:protein-phycocyanobilin linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16338">
        <property type="entry name" value="CpcT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01460">
        <property type="entry name" value="Chrphore_lyase_CpxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010404">
        <property type="entry name" value="CpcT/CpeT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038672">
        <property type="entry name" value="CpcT/CpeT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35137">
        <property type="entry name" value="PTHR35137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06206">
        <property type="entry name" value="CpeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="22448" checksum="11E906F894AED669" modified="2013-03-06" version="1">MSKSTDVKGLARLMAADFSNQQQAWDNPPFFAHIRVCMRPLPESLLGGTSLFLEQAYDFLLNQPYRLRVFKIQAVDDHLELEHYKLKEEAEFYGASRNREKLKELTIDHLEKMNGCDMIAEWNGSHFKGYIKPGKACIVVRKGKESYLDNSFEIDERKLISFDRGRDLVTDELLWGSVAGPFHFTRIESFAHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z561</accession>
    <name>K9Z561_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="5" type="synonym">rpl20</name>
        <name evidence="7" type="ordered locus">Cyan10605_1576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219412.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1576"/>
    <dbReference type="EnsemblBacteria" id="AFZ53685">
        <property type="protein sequence ID" value="AFZ53685"/>
        <property type="gene ID" value="Cyan10605_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1576"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1673"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_3"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="13511" checksum="6B0C23D7C6C04509" modified="2013-03-06" version="1">MTRVKRGNVARKRRKKILKLAKGFRGSHSKLFRTANQQVMKALRNAYRDRRKKKRDFRRLWITRINAAARVHGISYSQLINKLDKANISLNRKILAQLAIQDAEAFQKVVELAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A5</accession>
    <name>K9Z5A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220049.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2238"/>
    <dbReference type="EnsemblBacteria" id="AFZ54324">
        <property type="protein sequence ID" value="AFZ54324"/>
        <property type="gene ID" value="Cyan10605_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2238"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2379"/>
    <dbReference type="eggNOG" id="ENOG502Z8F2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064695_0_0_3"/>
    <dbReference type="OMA" id="YVHNVTE"/>
    <dbReference type="OrthoDB" id="1344004at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939114" evidence="2">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="32110" checksum="BAD2451A2685C26A" modified="2013-03-06" version="1" precursor="true">MFKRIVALFLTIFLSFGTFACGTPNSEAVSNSNNFNNNTNIPSNNIASGKYPVQQATFNDIDGEYTLMLLNTPAGSSPVFRTTNLQMARLTDEEIKEGQSTYAEIKGNEAIMHLTEDFRIEYVHNETQTVTNPDTGRQETVIVRRESNFWTPFAGAMAGQALGSLLFTPRYYVPPVYSGGNLSGIGGYGSTYNQAVQSYRSNYNSVPTVEKNRQSFRSTGTLKNSSGNTINRVNSNNSKATGSGFGSSDLKNSGNSSKYKQPSKNSFGSNKSSGYRRTTPARRSGGFGSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A9</accession>
    <name>K9Z5A9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ordered locus">Cyan10605_1482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219322.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1482"/>
    <dbReference type="EnsemblBacteria" id="AFZ53593">
        <property type="protein sequence ID" value="AFZ53593"/>
        <property type="gene ID" value="Cyan10605_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1482"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1574"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_3"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="44781" checksum="B0E31F6FF5D6C347" modified="2013-03-06" version="1">MKVLVVGNGGREHALAWKLLQSDSVEKVFCTPGNGGTAVLEKCENVAIAVDDFASILNLVQEKGIELVVVGPELPLSLGIADYLQPHGVKVFGPKQDGAIIEASKSWAKDLMVAGGIPTAKSATFTSASPAKEYIKKEGAPIVVKADGLAAGKGVIVAMTEKEALDAIDELFAQDFAKVVVEEFLTGQEVSILALTDGNTIRPLISAQDHKQIGEGDTGANTGGMGAYAPTPLLDDNLSQRITKEVLEPTLKQLQEKNIDYVGVLYAGLMITPEGEPKVLEFNCRFGDPETQAVLSMLKTPLIDILLACTEKRLAELPPFEWHEGSAVCVVMAAGGYPSSYRKGDVISGIPTAQEEGVMVFHAGTKLNNGQILTDGGRVLGVTGRGSDFKDAIASTYRGVAKIHFDNMYYRRDIGHRISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C6</accession>
    <name>K9Z5C6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2259"/>
    <dbReference type="EnsemblBacteria" id="AFZ54344">
        <property type="protein sequence ID" value="AFZ54344"/>
        <property type="gene ID" value="Cyan10605_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2259"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2245469_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="12119" checksum="2E2298BD9093E3B0" modified="2013-03-06" version="1">MLFFMTEWIINTMNSLRYVGIALLMFSENLFPPIPSELIMKINSFIIYSTVGTLIWVSLLTSTNYILGENYTLIEKYIAPISKITLLSIVFLFVIWVIKKQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G3</accession>
    <name>K9Z5G3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1697"/>
    <dbReference type="EnsemblBacteria" id="AFZ53800">
        <property type="protein sequence ID" value="AFZ53800"/>
        <property type="gene ID" value="Cyan10605_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1697"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1803"/>
    <dbReference type="eggNOG" id="ENOG502ZCFJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330584_0_0_3"/>
    <dbReference type="OMA" id="VGWFYRL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21250" checksum="BE634EDA42379188" modified="2013-03-06" version="1" precursor="true">MHFDNISLIQILAVLSASAAGGLRIGLPLLIIGLIRIDQLWHNIPFLSSFPPQVVIGILSSWSLFELLGNKKLIGLRIIQIIQLIFSPFAGGIMAVGVARLLEVQITPLWFLGLIGGLFAFVLKLVQVGWFFRLGKIPIIFIFIEDFLSAILVIFALDAPENGGLIAMLLLWIAIRSSTEWKYRRETISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J9</accession>
    <name>K9Z5J9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">META domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219395.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1559"/>
    <dbReference type="EnsemblBacteria" id="AFZ53668">
        <property type="protein sequence ID" value="AFZ53668"/>
        <property type="gene ID" value="Cyan10605_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1559"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1656"/>
    <dbReference type="eggNOG" id="COG3015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043917_0_0_3"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="30812" checksum="E54718735BB62350" modified="2013-03-06" version="1" precursor="true">MKYKLILIPTVLLSLLIPNYFLSNSLKAQNSEDIMESVTPAIGDTSQNSLDWNGVYEGILPCASCEGIKTTIILNQDLTFVQQVQYLGIDERTWETKGTFQWNEAGNRITLQGIEQAPNQFIVGENRLIQLDMNGDRISGDLADKYILNKVAQASMTEDFLTDVRWQLTEMMGKPVTKSENQREPIFLIFNSEENRVNGFAGCNNFMGGFELKEGNRLTLKQMASTMMACENMETEISFLRTLEQVDNYTIKDGVLSLNKAKMSPLLVFTMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P1</accession>
    <name>K9Z5P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2386"/>
    <dbReference type="EnsemblBacteria" id="AFZ54469">
        <property type="protein sequence ID" value="AFZ54469"/>
        <property type="gene ID" value="Cyan10605_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2386"/>
    <dbReference type="eggNOG" id="COG3900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074811_2_0_3"/>
    <dbReference type="OMA" id="CEHLAFR"/>
    <dbReference type="OrthoDB" id="1203353at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019207">
        <property type="entry name" value="DUF2092"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09865">
        <property type="entry name" value="DUF2092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012443">
        <property type="entry name" value="UCP012443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939125" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="28688" checksum="190371E2818E4D27" modified="2013-03-06" version="1" precursor="true">MNSLRILLTCSLFITSSFELAAKIQAQTVPVMPTEETPITTEELLTQVCDFLKGQQFISVEMDITYDNVLTSGSKVQYGGYKTVSVQRPNMVRVDTVADQGNRNFYYDGKTITLFSPTLKVFATKEAPANIDEMLNTIEEKLGFTIPMFNLFTSNPCAVLDNTVEEPLYIGSNLVNREETDQILIVTADWDGQLWISQDETPLVKKAIVTYKNLPNAPQYTVLFSNWNFKPSFAPDTFTFTPGQDNFKVQILPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z8</accession>
    <name>K9Z5Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219887.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2073"/>
    <dbReference type="EnsemblBacteria" id="AFZ54162">
        <property type="protein sequence ID" value="AFZ54162"/>
        <property type="gene ID" value="Cyan10605_2073"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2073"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2203"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_3"/>
    <dbReference type="OMA" id="AYPDQVF"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="52101" checksum="03DE60B9FA245F33" modified="2013-03-06" version="1">MTVSNSEKQKNPLPWIFGIMTGGILLIVGIAYSSINRPKTSNIIDQYTVTVQRENIALEIQASGTVEPIQSVNISPKNPGRIVKLLVDQGVIVKKGQPIAVMENEELYVQGIQAEARLKEAQSALQETDIRIQGEIQALSAQLAQAVARLEESKQRIPKQMDQVRSQLKEAESRLRLAETQLKRNENLLKEGAISQDQFDQLANQYLVAQADIQEVLQRLQELQATEDPEIKRLEASVGEVKIALEERQVRRQAEIEKLKANVESAKADLEIAKIQYQDSFITAPFDGIITQRFATEGAFVTPTTSASSTASATSTSIVALARGLEIVAKVPEIDLNQIQIGQPVEIVADAYPNQTFQGVVRAIAPEAIIEQNVTSFEVKIDILTGKEKLLSKMNVEVNFIGRQLDNVLVVPTVAIVTEKGQTGVMIPNQENEPEFQPITIGASVDDKTQVLSGVMPGQKVFIDLPPSQQPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z616</accession>
    <name>K9Z616_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220354.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2551"/>
    <dbReference type="EnsemblBacteria" id="AFZ54631">
        <property type="protein sequence ID" value="AFZ54631"/>
        <property type="gene ID" value="Cyan10605_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2551"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2708"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_0_2_3"/>
    <dbReference type="OMA" id="YLCFLAG"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="81"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="286" mass="30691" checksum="CF29BAA429492BA9" modified="2013-03-06" version="1" precursor="true">MTQIQKIPPDGKEKIKSSPSHNTKKFLFYLGLGLIALIVVLTLGPVISHPIEKLISLVENRYQEWFEQQDTANPLILITLAFLGGLIASVSPCILALLPVNLSYIGTLKIKSRWDAFKKAGLFVLGSVVILSLFGLVSSFAGAVMVEYRGYINIVVGLIMAVMGLWLLGVIKINLPETELNLPKAGPFGVGLTFALVSSPCASPVLFAVLAAAAATGSQVLATLTMVSYALGYTMLIFLASLFTGLAKQSNNLLKHSEGIIRFGSVALLMTGAYYLFTGTKWFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z619</accession>
    <name>K9Z619_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220312.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2508"/>
    <dbReference type="EnsemblBacteria" id="AFZ54589">
        <property type="protein sequence ID" value="AFZ54589"/>
        <property type="gene ID" value="Cyan10605_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2508"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2658"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_3"/>
    <dbReference type="OMA" id="PFWANTQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="430" mass="48970" checksum="83DA734751BFE2AF" modified="2013-03-06" version="1" precursor="true">MSFQFSFRISNLLSFLKKQFRYISILLIILFFVLVNVVYSTEKTTITLMIQALEAAQWQNLVEKFERENPDIDLEIISAPNATNLVEDLYTSAFLLGDSPYDLVYLDIVWVQKFAAANWLQPLNNFISEDELKQFLKGDVEGGKYQDSLYRIPFRSDGGMLYYRTDLLEKNGYNPPETFTELINISQDLQAKGKAKWGYVWQGRQYEGLSAMFVEVLQGFGGYWINSDTLEVGLDSPEAIASVQFLLDTIKKGISPSGVTTYAEEETRRIFENGQTVFLRNWPYVAGLASKSEIAGKFSLKPMVHQPQHQSGACQGGWGLGMSKNTKHPEEAWRVIEFITSEDSQRDFILETGYVPSRKSLFNDPQIVEKYPYYPQLLTVVENSVLRPPIAQYAQASDILQRYLSAALTQTMTPENAMKKAATETRQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z629</accession>
    <name>K9Z629_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+))</fullName>
            <ecNumber evidence="5">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220369.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2566"/>
    <dbReference type="EnsemblBacteria" id="AFZ54646">
        <property type="protein sequence ID" value="AFZ54646"/>
        <property type="gene ID" value="Cyan10605_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2566"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2723"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_3"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="463" mass="49320" checksum="EAFB27E6CC613E24" modified="2013-03-06" version="1">MTDLTPSSSFSLAVHLELLNRAGALAKVTNAIASVGGSLGNITLIERNLQTVKRELQIDASSSDHADKILDAIKSLEDVKILQVSDRTFELHKGGKIRIENRIEIKNSSDLAMAYTPGVGRICKAIAEKPEEVFSLTIKSNSIAIVTDGSAVLGLGNLGAEAALPVMEGKAMLFKGFADIDAFPICLATQDVEEIISIVKNIIPVFGGVNLEDIAAPRCFEIEKRLQEELDVPIFHDDQHGTAIVTMAALINALKLVGKEIDKIRVVINGAGAAGVAIARLLNQAQCYNITLCDSKGIISKDRENLNAEKQLLAVEKGGTLADALVDADVFIGVSAPNILTPDMVKTMAKDTIIFAMANPIPEIQPELIKDIAAVVATGRSDYPNQINNVLAFPGIFRGALDCRAKGLTTEMYLQAAGAIASLVSTEELNKEHIVPSVFDPRVATVVAEAVKKAAREAGVARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z649</accession>
    <name>K9Z649_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ordered locus">Cyan10605_2103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219917.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2103"/>
    <dbReference type="EnsemblBacteria" id="AFZ54192">
        <property type="protein sequence ID" value="AFZ54192"/>
        <property type="gene ID" value="Cyan10605_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2103"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2236"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_3"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="115"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="337"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="496" mass="54459" checksum="DC6E95FFFBF7F162" modified="2013-03-06" version="1">MKLRQLLADLNYLTPLTNHPNWDQEVKGITTNSHSCGIGDVFIGMPGTRVDGGEFWQSALAEGAIASIISQEASQKIPPTDNDCVIVADDIPSICADIASKFYGYPSEKLKMVGVTGTNGKTTTTHLIEFFLNQAVQKTALFGTLYARWQDYQKTATHTTPFAVDLQAQLAEALEAKNEYVVMEVSSHALAQKRIRGCHFDVAVFTNLTQDHLDYHKDMEDYFEAKALLFSEDYLRGRAIINYDDDYGQRLIQRLAQKQVWSYSVNNTSADLYTSDLTYQADGVKGILHTPEGSINFSSPLVGQFNLSNLLASVGAVLSLGVSLEVITENLSAFAGVPGRMERVHFLPHQDISVIVDYAHTPDSLENLLQAARPFISGKMICVFGCGGDRDRTKRPIMGKIAAQGADIVVVTSDNPRTENPEQILADILTGIPEDIKPIVQCDRALAIQEAISMAQSGDGVLIAGKGHEDYQILGTEKIHFDDREEARKALSQKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B8</accession>
    <name>K9Z6B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219845.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2029"/>
    <dbReference type="EnsemblBacteria" id="AFZ54120">
        <property type="protein sequence ID" value="AFZ54120"/>
        <property type="gene ID" value="Cyan10605_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2029"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2156"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_3"/>
    <dbReference type="OMA" id="TREYEGI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="412" mass="45801" checksum="1DBE804B5BD656F0" modified="2013-03-06" version="1" precursor="true">MRKFLIIWSGQLLSTIGSNMTNFALTIWAWEKTGTATALAFISFAFLAPTLITGLFMGVIVDRFERKLLMILGDIITGTVSVILLLIYTFSSLEIWHIYLLIAITSPFSQLQSLASESITADLVTPENYIRAGSLTSILNYGSQIVAPALAGFLYPIISLTGILFIDLFTLILAIFTVIITPIKEKKIKLHSNKITDNLTEIFIYLKENKYFLTIITIEILFWFIHDIGGSIFKPLILSRTDGNTFILGSISASAGIGGVMGGLIITFWGKIKNRFKGFIIGIMGASICKLIFGFGQSILIWLPLQFCSSLNFPLIYSTRQGLYLDLIPSNLQGRIFAFSSWLRLGVGAISALLGGILADRIFEPWMMTDNIFSPLFGTQKGAGMNLLYVLCSVGMFFVGLWGWYSRKRMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B9</accession>
    <name>K9Z6B9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="3 9">4.3.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">FO synthase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cofG</name>
        <name evidence="11" type="ordered locus">Cyan10605_2647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The FO synthase complex consists of two subunits, CofG and CofH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="3 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220444.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2647"/>
    <dbReference type="EnsemblBacteria" id="AFZ54721">
        <property type="protein sequence ID" value="AFZ54721"/>
        <property type="gene ID" value="Cyan10605_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2647"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2812"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054174_0_0_3"/>
    <dbReference type="OMA" id="TTACRYT"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="35766" checksum="83150411D786057F" modified="2013-03-06" version="1">MAKIITYSPAYTLVPTYECFNRCSYCNFRTNPFQSPWLELETAKQILTSLEHQGIIEILILSGEIHPLSPRRKLWIERIYDLAKLALSMGFLPHTNAGVLSYEEMALLKEVNVSLGLMVEQVSPKLLDDVHKHAPTKIPQLRLQQLQWAGELKIPFTTGILMGLGESKQDRKDSLDAIALLHGQYGHIQEVILQPYQPGKKDIFQGKPLNDEEILEVIALAREILPKDIALQIPPNLLKNSQLILKSLELGVTDLGGIVPKDEVNPDYHHQKIDLLRQELLQQGYQLKPRLPVYPQYYSWLSDSLQSSLYQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D3</accession>
    <name>K9Z6D3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1868"/>
    <dbReference type="EnsemblBacteria" id="AFZ53968">
        <property type="protein sequence ID" value="AFZ53968"/>
        <property type="gene ID" value="Cyan10605_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1868"/>
    <dbReference type="eggNOG" id="ENOG5033BAD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3186592_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="46" mass="4786" checksum="233A41C2E36B3B93" modified="2013-03-06" version="1">MSDLNRGIMKFDGADKPIVVAVSAVIILGSIAALIIWALKVAYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E5</accession>
    <name>K9Z6E5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220042.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2231"/>
    <dbReference type="EnsemblBacteria" id="AFZ54317">
        <property type="protein sequence ID" value="AFZ54317"/>
        <property type="gene ID" value="Cyan10605_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2231"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2372"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_3"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="23741" checksum="5B15099F23D01C46" modified="2013-03-06" version="1">MAPQLKIYVPPHPLIKHWLGVARDKNTPSTLFKTAMVELGRWLTYEAIREWLPTMDVTVETPLALAPATFLNPETKIAIIPILRAGLTLAEGSQTILPLASTYHLGMIRDEKTLNPTCYLNKLPTQFTADTHILILDPMLATGGTIILAMEEIIKRGGNPDLTRIISVVSAPPALQKLSANYPTLNIYSAMIDEQINDNGFIVPGLGDAGDRAFGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P3</accession>
    <name>K9Z6P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2132"/>
    <dbReference type="EnsemblBacteria" id="AFZ54220">
        <property type="protein sequence ID" value="AFZ54220"/>
        <property type="gene ID" value="Cyan10605_2132"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2132"/>
    <dbReference type="eggNOG" id="ENOG502ZFPV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217152_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="46" mass="5446" checksum="8EF7B626D28DAF9A" modified="2013-03-06" version="1">MKTELKTTNYNLEQLQKAYQADQQVKYMSLEAELELLLQQIKTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q8</accession>
    <name>K9Z6Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2348"/>
    <dbReference type="EnsemblBacteria" id="AFZ54432">
        <property type="protein sequence ID" value="AFZ54432"/>
        <property type="gene ID" value="Cyan10605_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2348"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101369_0_0_3"/>
    <dbReference type="OMA" id="TTGRMNR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025478">
        <property type="entry name" value="COP23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14218">
        <property type="entry name" value="COP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23592" checksum="3999016FE72201DF" modified="2013-03-06" version="1" precursor="true">MKPRFALVFSLILSLIFGQIISLIFVNFAQADSKKNAYSCIDHEGKPMTVVDTTRGRIQLIVWESDYFRASGWTPEKRCQEVSKRFQQFSDNSTLRFIANGMIGKYQVICVSPQSPPPSTNIVCQEQNLLMTLEPKDKPVEVMKQLFEDAVKIGAMPIRRGQAVLDLDKYFAVAPLMDAVSPIQKPPLIPEEKKPPQSGTTIECPPILCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T0</accession>
    <name>K9Z6T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219828.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2009"/>
    <dbReference type="EnsemblBacteria" id="AFZ54103">
        <property type="protein sequence ID" value="AFZ54103"/>
        <property type="gene ID" value="Cyan10605_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2009"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_3"/>
    <dbReference type="OMA" id="MMSSWKL"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="36319" checksum="C51A88B676180848" modified="2013-03-06" version="1">MEANSVDSSILKEIPSENRRILIVIISISLGLLITFCLSLSIGSVSLSLEEIYQALWHRGAELNQVIVWDLRLPRILAAFVVGSALGTSGALLQGMLRNSLATPFLLGISAGAGLVVVVLITFDLFLFLIPVASWLGAVLTTMLVYFLARQNNDINVERLILGGVAVSSLFGAIQTTLLILSEDGRIQKALNWIVGSLNGRGWTELNTATPYILIALIIACLLARFVNVLNLGDELAVGLGIPLARSRLLIGGTATLLAASAVSIAGLIGFVGLLVPHSMRFLLKSNDYRLLIPLSAVGGAIVLSWADLLSRIGAVELPVGAVTALVGSPLFVWLLYKRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X2</accession>
    <name>K9Z6X2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyanophycin synthetase</fullName>
            <ecNumber evidence="7">6.3.2.29</ecNumber>
            <ecNumber evidence="6">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="7"/>
    <dbReference type="EC" id="6.3.2.30" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220663.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2875"/>
    <dbReference type="EnsemblBacteria" id="AFZ54941">
        <property type="protein sequence ID" value="AFZ54941"/>
        <property type="gene ID" value="Cyan10605_2875"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2875"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3055"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016806_0_0_3"/>
    <dbReference type="OMA" id="PFMIANA"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044019">
        <property type="entry name" value="Cyanophycin_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18921">
        <property type="entry name" value="Cyanophycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="224"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="870" mass="95103" checksum="07C52D721F801191" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z735</accession>
    <name>K9Z735_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219903.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2089"/>
    <dbReference type="EnsemblBacteria" id="AFZ54178">
        <property type="protein sequence ID" value="AFZ54178"/>
        <property type="gene ID" value="Cyan10605_2089"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2089"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2220"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_3_0_3"/>
    <dbReference type="OMA" id="DVTPVIW"/>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10850" checksum="FC885CD7274110E6" modified="2013-03-06" version="1">MNIAIIASVILGILLLIMTVLFIFRIILTWYPNIDLTQFPYSLAYIPTEPFLAFTRKIVPPLGGIDISPVIWLGIITLLREILLGQQGIITLALRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z747</accession>
    <name>K9Z747_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.262</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(phosphohydroxy)-L-threonine dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxA</name>
        <name evidence="5" type="ordered locus">Cyan10605_2964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32275"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="EC" id="1.1.1.262"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The active site is located at the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PdxA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220745.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2964"/>
    <dbReference type="EnsemblBacteria" id="AFZ55026">
        <property type="protein sequence ID" value="AFZ55026"/>
        <property type="gene ID" value="Cyan10605_2964"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2964"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3155"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_1_0_3"/>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00536">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037510">
        <property type="entry name" value="PdxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="345" mass="38029" checksum="C93DC5F11C5C297E" modified="2013-03-06" version="1">MINQSGSKVDLAITMGDPASIGGEIILKALSRPSIHDRANITIIGSRSHLEKTYHHLQPFTSQELIHPDSLNIIEVDTPENIIWGKGNQETGKASFLYLENAIALTLNGQFEGIVTAPIAKSLWQSAGYDYPGQTEVLAQKSGREKFAMMFLGLSPYTNWVLRTILATTHIPLKTVSDNLNSSILDSKLELLIENLKQDFNLEKSTIAVAGLNPHSGEDGKLGIEEKEWLQDWLINAQKKYPQVKLIGLIPPDIMWIKPTQAWFRDGNIDTPDAFLALYHDQGLIPVKAMAFDQAVNTTVGLPFVRTSPDHGTAFDIAGQGVANPSSMLSAIEWAIALCYNRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z771</accession>
    <name>K9Z771_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220713.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2932"/>
    <dbReference type="EnsemblBacteria" id="AFZ54994">
        <property type="protein sequence ID" value="AFZ54994"/>
        <property type="gene ID" value="Cyan10605_2932"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2932"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124876_0_0_3"/>
    <dbReference type="OMA" id="LEEHQFL"/>
    <dbReference type="OrthoDB" id="1975038at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03603">
        <property type="entry name" value="CLECT_VCBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034007">
        <property type="entry name" value="CTLD_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="19472" checksum="46439F85B3F75F72" modified="2013-03-06" version="1" precursor="true">MIFNQKLNHYQKLFLLTLTNILMVNYSLNAQEKEIFVNPNNGNKYFLTSEMSWQDGQNLAEKMGGNLVTVNDEKENQWLIETFITSETNFLWIGINDQAVEGEFIWISGEMSNYLNWAEGEPNNNPQQGGEHFGVINGLNNPFKRPVGTWSDAPEQAKLKGIIELKNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z777</accession>
    <name>K9Z777_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phycobilisome linker polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the phycobilisome linker protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220718.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2937"/>
    <dbReference type="EnsemblBacteria" id="AFZ54999">
        <property type="protein sequence ID" value="AFZ54999"/>
        <property type="gene ID" value="Cyan10605_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2937"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3125"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086930_0_0_3"/>
    <dbReference type="OMA" id="GFPQIIW"/>
    <dbReference type="OrthoDB" id="1021247at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001297">
        <property type="entry name" value="PBS_linker_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038255">
        <property type="entry name" value="PBS_linker_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016470">
        <property type="entry name" value="Phycobilisome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00427">
        <property type="entry name" value="PBS_linker_poly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005898">
        <property type="entry name" value="Phycobilisome_CpeC/CpcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51445">
        <property type="entry name" value="PBS_LINKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="PBS-linker" evidence="6">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="29079" checksum="18771785700BCD6A" modified="2013-03-06" version="1">MNLPLLKYAPSSQNTRVAGYEVGGDEQPKIYDAENLYSPSDMDNLIEAAYRQIFFHAFKSDRETILESQLRNRQITVRDFIRGLLLSETFKNSFYEKNSNYRFVEHCVQKVLGRDVYSEKEKIAWSIVVATKGLRGFIDQLLDSDEYLENFGYDIVPYQRRRYLPSREQGEMPFNIKSPRYDAYYRGILGFPQIIWQNQVRRFIPQEKQAKAGDPSLYLNMARSINAQASPTPRVSAQNISLDKVPYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C3</accession>
    <name>K9Z7C3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220763.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2984"/>
    <dbReference type="EnsemblBacteria" id="AFZ55044">
        <property type="protein sequence ID" value="AFZ55044"/>
        <property type="gene ID" value="Cyan10605_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2984"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3178"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_2_1_3"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="16852" checksum="263B09BC0C85FDB5" modified="2013-03-06" version="1">MPRVVLVHPQIPPNTGNIARTCAATETELHLVAPLGFEISDRTLKRAGLDYWPHVKLTYHSSASEFLQFAKEKGGRIIGLSVRGKENYLKCQYQEDDWLLFGSEIDGLPPFVLKECDLTSYITMKSNNVRSLNLSVSVSVVLFESIRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D0</accession>
    <name>K9Z7D0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220820.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3044"/>
    <dbReference type="EnsemblBacteria" id="AFZ55101">
        <property type="protein sequence ID" value="AFZ55101"/>
        <property type="gene ID" value="Cyan10605_3044"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3044"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_5_3"/>
    <dbReference type="OMA" id="SYLEWNQ"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="34076" checksum="6A78D38FEE03C568" modified="2013-03-06" version="1">MNREKLALGNLNLAYLEWKNQGLLEGKSQNILLLHGMADNCLVWQKLGEFLSTNNRNYHIIAPDLRGHGDSSKPKTGYFKDDYLEDLSKIYQHFNWQKAHIIAHSWSAKIACIWATQNPQLCQSLTLIDPFFINSMPSFFSLTFPILYKVLPFLKLMQLFPDYLSIEKTAKTLKQYQGWTPWQQEIFNYGIEQKKDGYWSSKFSQAARNEIFEDVMKEKGLTTKLDLPSLLVLPEKGLNRTSWQISPYKQYLTNLQIAKVKGNHWAFIVEPDEFNQTINQFLQSLQLEKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F7</accession>
    <name>K9Z7F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SirA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220038.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2227"/>
    <dbReference type="EnsemblBacteria" id="AFZ54313">
        <property type="protein sequence ID" value="AFZ54313"/>
        <property type="gene ID" value="Cyan10605_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2227"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_2_0_3"/>
    <dbReference type="OMA" id="RMNEGEP"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8021" checksum="AE29E9A90E166F13" modified="2013-03-06" version="1">MAQLLDLRGTPCPINFIRSKLQLEKMSQGDVLEIHLDGGEPIEQVPNSLSMEGYSIEAIEDKGEYFVLSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K4</accession>
    <name>K9Z7K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220415.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2617"/>
    <dbReference type="EnsemblBacteria" id="AFZ54692">
        <property type="protein sequence ID" value="AFZ54692"/>
        <property type="gene ID" value="Cyan10605_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2617"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526500_0_0_3"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="111"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="517" mass="59927" checksum="AFDEBCFCEB7443DE" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N3</accession>
    <name>K9Z7N3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">Cyan10605_2324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220132.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2324"/>
    <dbReference type="EnsemblBacteria" id="AFZ54408">
        <property type="protein sequence ID" value="AFZ54408"/>
        <property type="gene ID" value="Cyan10605_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2324"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2468"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_3"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
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            <end position="160"/>
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            <position position="192"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="244"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
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            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
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    </evidence>
    <sequence length="425" mass="46047" checksum="730DC45984A1D39A" modified="2013-03-06" version="1">MVATPTKINYDIKDINLAGVGKQRIEWAAREMPVLAQITERFRQEKPFAGIRLVACCHVTTETANLAIALQAGGADAILIASNPLSTQDDVAACLVKDYGIPVFAIKGEDNATYHRHVQTALDHKPNIIIDDGSDVVATLVKERQHQLADLIGTTEETTTGIVRLEAMFKDGVLTFPAMNVNDAETKHFFDNRYGTGQSTLDGIIRATNVLLAGKNLVVAGYGWCGKGVAMRGRGLGANVIVTEINPVKAIEAAMDGFRVMPMAEAATIGDVFVTVTGNKHIIREEHFAVMKDGAMVCNSGHFDIEIDLEALKTLSTEIKEVRNFTQQYILKNGKSVIVIGEGRLVNLAAAEGHPSAVMDMSFANQALACEYLVKNKETLQPGIHSIPTEVDQEIAALKLQGMGINIDSLTPEQIEYMNSWTVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P0</accession>
    <name>K9Z7P0_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ordered locus">Cyan10605_2663</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
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            <begin position="241"/>
            <end position="288"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="EMBL" id="AFZ54737.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="861" mass="100132" checksum="D6EBC81DCB8BF18B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="64" mass="7204" checksum="43E188F7C002D9C0" modified="2013-03-06" version="1">MRLLYTMPYTTEDGGRLNNFANEPKVYQAEPPNKNQKRNYIIWGALAIILLGGVVAIAFYASNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P9</accession>
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        <submittedName>
            <fullName evidence="9">6-phosphofructokinase</fullName>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2843"/>
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        <property type="reaction ID" value="UER00182"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
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        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="6"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="44585" checksum="A65A2114D9B56103" modified="2013-03-06" version="1">MKTKKRIGILTSGGDCPGLNAIIRAVVKYATLRGWEVYGIPRGTDGFIDFVHGKLNIEELKLHPHGYDLPGVLQGLDVLQFMSGSVLGSLSRGNPQEDQVTQDIIKGYEALELDALIAIGGDGSLDIIYDLAKKGNWNLVVIPKTIDNDVAFTERSVGFDTARNTVTQALYDLTFTAASHERIMVVQVMGRDAGHLSLHAGIAGGADCILIPELTPQLTEDTLVGMCEYIAQLRKDRRKFALIVIAEGVKGLNAEKDPYIAETLADLLKEKSHQLCSTEGDRYCGLNQIDTRAMVLGHLQRCGVPSSFDRILATVFAIKALDLIGEECYNRLVIWQNGSVESKSLEQIMPMIKWCHQEKTCPAPVDPEGFMVRTALSLGIYLGESHYHPHTSNYPYTPLASTITNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z808</accession>
    <name>K9Z808_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221044.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3280"/>
    <dbReference type="EnsemblBacteria" id="AFZ55326">
        <property type="protein sequence ID" value="AFZ55326"/>
        <property type="gene ID" value="Cyan10605_3280"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3280"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3495"/>
    <dbReference type="eggNOG" id="COG4279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053146_2_1_3"/>
    <dbReference type="OMA" id="NPCKHIS"/>
    <dbReference type="OrthoDB" id="1906220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="283" mass="32165" checksum="E3DDF7082BE09856" modified="2013-03-06" version="1">MIERQWWVEKWLELLDSYRFKKRLERGRNYSREGNVLNIEFNKQSQLIAQVQGTEEKPYRVTLALDAFSDEDWGYVIATMSDKAMLSAQLLVGEMPLEIEQVFIKNGLSLFPFNLADVRSRCTCPDKANPCKHIAAVYYQLADRFSEDPFIIFQLRGRSKAQILEALRVSRSLQLSGKEFEPEKLGKIKSLPKRKTNPHKTSAPLSIDNFWEYDEPLDSSLVVITPSTENKTIIDVLGDIPLPYNDSQAVMQYLTQVYQLVPSKAMTIAEGTATPSSEGASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z810</accession>
    <name>K9Z810_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220594.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2805"/>
    <dbReference type="EnsemblBacteria" id="AFZ54872">
        <property type="protein sequence ID" value="AFZ54872"/>
        <property type="gene ID" value="Cyan10605_2805"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2805"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2982"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081003_0_0_3"/>
    <dbReference type="OMA" id="MGLYAEE"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="29277" checksum="315DB4B34BB0CA4C" modified="2013-03-06" version="1">MKVFWNIIAIIQKELHGYFVSPLAFSVAAVFWLISGIFFVFLLLSEQGIIQSVAIQEQLGNTAPVDVVYEFMQIYFNAIASLTLFILPILSMGLYAEERKRGTIELLATSPLFNWVVALGKLMGVLIFFTTMIMPIILYEAIAFQGATPPISLQVPLLAHLGLILMAASILSLGMFISSLTDSTIFSAIITFILVITLSILDALANSIGGQLGEFLAHFSLLKNYENFVMGIFNSSNLIVFLTYIFLGLFLTSQSIEVFRFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z818</accession>
    <name>K9Z818_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2631"/>
    <dbReference type="EnsemblBacteria" id="AFZ54705">
        <property type="protein sequence ID" value="AFZ54705"/>
        <property type="gene ID" value="Cyan10605_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2631"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_3"/>
    <dbReference type="OMA" id="QRRWYRL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12212" checksum="F0C70B3F335614F8" modified="2013-03-06" version="1">MSSITIESQKEVMSGFRALSDTIRIKVLELLSTRELCVCEISEVLDISQSKLSFHLKTLREANLVNSRQQGKWTYYSLNLSQLVALEQYLADFRRNTVLLPTRLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z836</accession>
    <name>K9Z836_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3263"/>
    <dbReference type="EnsemblBacteria" id="AFZ55309">
        <property type="protein sequence ID" value="AFZ55309"/>
        <property type="gene ID" value="Cyan10605_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3263"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3478"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_3"/>
    <dbReference type="OMA" id="GMQDTLT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="32589" checksum="50F6664922B50D50" modified="2013-03-06" version="1">MINKFLNTVIDAINDLIADTIKIIPGLIGGLIVIFLTRYIAHWTENFANKIAIKTIKSRSLQILFIKSIYITTWVVGVFLAAIMSFPGLSLGNVIGALGLGSVAIGFAFQDIFKNFLAGILLLLQEPFRIGDEVVVQDYQGFVEHIDIRTTTIRTYQGEKILIPNATIFTNSVQVRTGYDKRRTDLGVGVDYNTSLAQAQNLLFDVITSLDGVLKEPTPEIDLVNFGDSSIDFVVRYWTLPQQKTVRYIQTKAIIAIKKAFDKASITIPYPIRTLYYFDQDKYSDYIPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z865</accession>
    <name>K9Z865_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221104.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3344"/>
    <dbReference type="EnsemblBacteria" id="AFZ55386">
        <property type="protein sequence ID" value="AFZ55386"/>
        <property type="gene ID" value="Cyan10605_3344"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3344"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3562"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113892_1_1_3"/>
    <dbReference type="OMA" id="YSKPGCH"/>
    <dbReference type="OrthoDB" id="2001991at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10396" checksum="8997DCD7A4216843" modified="2013-03-06" version="1">MELILYSKTGCHLCEGLEEKLREIDDIDINLEIRDITKNKEWWEKYQYEIPVLYLVMDGQEKLIPRNSPRISVNQLSKVLQKFANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z877</accession>
    <name>K9Z877_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221067.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3304"/>
    <dbReference type="EnsemblBacteria" id="AFZ55349">
        <property type="protein sequence ID" value="AFZ55349"/>
        <property type="gene ID" value="Cyan10605_3304"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3304"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3518"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072689_1_0_3"/>
    <dbReference type="OMA" id="TGWEMPV"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="30166" checksum="5F5823C7C3F75479" modified="2013-03-06" version="1">MKVLVSDFDGVICNGLLEYFYSSKLVYQKIWQTREINWQLLQEKFNILRPVVETGWEMPLLLRVLIDDRKTVDNILNHWQTVREKAIKTIEKEGITIKNLTKTLDEVRQKQIEENLQNWLNLHSFYEGIIPHIKKLINEGIKIYIVTTKSEKFTRQLLEKQEIFLPSVAIIGKEAKCPKYETIRSIIDTEKVNPQEVCFIEDRLEALELVYQQSDLQGVKLFLASWGYNTDYVRNKAKNLSHIQLLSLDNWRNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z894</accession>
    <name>K9Z894_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221134.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3374"/>
    <dbReference type="EnsemblBacteria" id="AFZ55416">
        <property type="protein sequence ID" value="AFZ55416"/>
        <property type="gene ID" value="Cyan10605_3374"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3374"/>
    <dbReference type="eggNOG" id="ENOG50332K1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2287822_0_0_3"/>
    <dbReference type="OrthoDB" id="1852084at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11606" checksum="AC0D1E091819D057" modified="2013-03-06" version="1">MANILLDLNSPVFQKDLFSLSKEDAYSVINTLKKITKIDWDSLYKSKGLKWELIYSKKGNKGENVYSFRINRKYRATALRDGNYLRVLSLHLDHDSTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B1</accession>
    <name>K9Z8B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220538.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54815">
        <property type="protein sequence ID" value="AFZ54815"/>
        <property type="gene ID" value="Cyan10605_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2746"/>
    <dbReference type="eggNOG" id="ENOG502ZAUU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353283_0_0_3"/>
    <dbReference type="OMA" id="WGYARIL"/>
    <dbReference type="OrthoDB" id="997306at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="792" mass="93929" checksum="41FFF64ACF1FC239" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q3</accession>
    <name>K9Z8Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220694.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2913"/>
    <dbReference type="EnsemblBacteria" id="AFZ54975">
        <property type="protein sequence ID" value="AFZ54975"/>
        <property type="gene ID" value="Cyan10605_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2913"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_2_0_3"/>
    <dbReference type="OMA" id="PLDECSE"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9260" checksum="1169275400D42996" modified="2013-03-06" version="1">MNNLSLPEVTENLDQLIDQITETHQPVIIKGTKNEVIMISSEDWSAIEETIYLNSISGYVDSIKEAIESPREEWVNAKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T3</accession>
    <name>K9Z8T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3536"/>
    <dbReference type="EnsemblBacteria" id="AFZ55569">
        <property type="protein sequence ID" value="AFZ55569"/>
        <property type="gene ID" value="Cyan10605_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3536"/>
    <dbReference type="HOGENOM" id="CLU_3097935_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="51" mass="5976" checksum="A5D45566970B8D5C" modified="2013-03-06" version="1">MKIEWLIFYALSILLISILFEKSIETQALVAELLKIFISGYLGYLIRQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J3</accession>
    <name>K9Z9J3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Photosystem I reaction center subunit VIII</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">psaI</name>
        <name evidence="13" type="ordered locus">Cyan10605_3196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-39</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">May help in the organization of the PsaL subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cellular thylakoid membrane</location>
            <topology evidence="3 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the PsaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="7/I/i=2-39"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z9J3"/>
    <dbReference type="EnsemblBacteria" id="AFZ55245">
        <property type="protein sequence ID" value="AFZ55245"/>
        <property type="gene ID" value="Cyan10605_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3196"/>
    <dbReference type="HOGENOM" id="CLU_215282_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00431">
        <property type="entry name" value="PSI_PsaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001302">
        <property type="entry name" value="PSI_PsaI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036357">
        <property type="entry name" value="PSI_PsaI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00796">
        <property type="entry name" value="PSI_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81540">
        <property type="entry name" value="SSF81540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03052">
        <property type="entry name" value="PS_I_psaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="39" mass="4045" checksum="0A55DA9914B6ADF1" modified="2013-03-06" version="1">MILGDFAASFLPAILVPAVGLVMPAVVMGLLFLQIESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T6</accession>
    <name>K9Z9T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221063.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3299"/>
    <dbReference type="EnsemblBacteria" id="AFZ55345">
        <property type="protein sequence ID" value="AFZ55345"/>
        <property type="gene ID" value="Cyan10605_3299"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3299"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3514"/>
    <dbReference type="eggNOG" id="ENOG502Z7Y0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092370_0_0_3"/>
    <dbReference type="OMA" id="SIDSFKM"/>
    <dbReference type="OrthoDB" id="1120115at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="28350" checksum="39A84FF54B2EC642" modified="2013-03-06" version="1">MSAIVFGSLPFPGQSGDQIVSKVVTTAIAALFKKTGKLEANVRAEPIAKILQGSIDGFDFVGKGMVMYNGLRLEAMELYLQAISIDFSAIFSGKVKLRQPTQATMRIVLTEEDLTRSFNTPFIIEKLQRLQYQGQSLHFQNTQITVNPDKSINIQSEIKVGDNTEYIPINMQTELHTESRTKIQFINPKFEGEENSIQLSQAILDHVNNLLDLDKFKLDGSRLRVDRARVKDKEFVFYGTVEIDRFPEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W8</accession>
    <name>K9Z9W8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3338"/>
    <dbReference type="EnsemblBacteria" id="AFZ55380">
        <property type="protein sequence ID" value="AFZ55380"/>
        <property type="gene ID" value="Cyan10605_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3338"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3555"/>
    <dbReference type="eggNOG" id="ENOG50333UZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188368_0_1_3"/>
    <dbReference type="OMA" id="DIMKVAI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="9875" checksum="5A3D838C5A8907AB" modified="2013-03-06" version="1">MLEINTKLTEKTADKLAYIQTQTQEEINQILELAIDNYYQKIKGKQKTSLELLEESGLIGCISAEPYLSTNYKSVIGEGLESKYDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA24</accession>
    <name>K9ZA24_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221287.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3539"/>
    <dbReference type="EnsemblBacteria" id="AFZ55572">
        <property type="protein sequence ID" value="AFZ55572"/>
        <property type="gene ID" value="Cyan10605_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3539"/>
    <dbReference type="eggNOG" id="ENOG503391G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617804_0_0_3"/>
    <dbReference type="OMA" id="ILESWNE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="443" mass="50168" checksum="8A2384FEE11D076A" modified="2013-03-06" version="1">MNIYLEKDIFKINDFIPSLIKGSSNFFYKLSPIAIIQTLPPIAFLNSVMENADIIDILINIPRIFLKSIHSINRAFNSETYDNLYTRGSQLLNGLEDETSLYQNVVKAYNNTLDIKYLETVINQTQPPINGNLGQSPSLLMNQWQEESVQLLFDTFNRLKDAISQLKGKLRRTAQNAFYRVRKTLEKVSRLIGFSFNGNNSRELKNFILNPLRITNYELQTTNYELRSRNGLTLTNPSMVAIVDILNEIAQFFLQSFLFAPVSRNLLPALSHTVTSIVLKYLGSGGAIASNYFAGHVLRANAGVLPVVFRATGMGGMAWTFLSAFAPWIIIAAVIIIIGIRSNQKLGEHLYLFGMGGEMPDMSYLILENSNNKEIYETIVNQGEKMKMESGKNYPHLYGFSVYEDKVVYGVDVANEQRILTKLETEMNFSPYVSLIDNFFTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAF2</accession>
    <name>K9ZAF2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Lysozyme</fullName>
            <ecNumber evidence="2 7">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
            <plasmid evidence="9">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 24 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2 7"/>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3537"/>
    <dbReference type="EnsemblBacteria" id="AFZ55570">
        <property type="protein sequence ID" value="AFZ55570"/>
        <property type="gene ID" value="Cyan10605_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3537"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095976_0_0_3"/>
    <dbReference type="OMA" id="KPYTIGW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4 7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="224" mass="25528" checksum="9475344C387F4430" modified="2013-03-06" version="1">MSLKQLKITKHLSELSSEQIRELQLLLNNCGYALIVDGILGDRTTKAFNSFKKQNYLEHPNLIGKTTIKKLLQFKPKQRQVNQAGMELIKEFEVFRRNAYLCPAGVPTIGYGNTFYPDGRKVKLGDTISHSEAEELFKITVDTFAKECDRLITVPVNDNQFSALVSFTFNVGVTAFRGSTLLRVLNQGNYQEAANQLLRWNRAGNRILEGLKRRRKAEKKLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAR4</accession>
    <name>K9ZAR4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221201.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3443"/>
    <dbReference type="EnsemblBacteria" id="AFZ55483">
        <property type="protein sequence ID" value="AFZ55483"/>
        <property type="gene ID" value="Cyan10605_3443"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3443"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3668"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_2_3"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="611" mass="68114" checksum="F59AFA22294AB127" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAW8</accession>
    <name>K9ZAW8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221251.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3499"/>
    <dbReference type="EnsemblBacteria" id="AFZ55533">
        <property type="protein sequence ID" value="AFZ55533"/>
        <property type="gene ID" value="Cyan10605_3499"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3499"/>
    <dbReference type="eggNOG" id="ENOG502ZUV5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188367_0_0_3"/>
    <dbReference type="OrthoDB" id="2057778at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9282" checksum="C5DF1F5EAB5AA00F" modified="2013-03-06" version="1">MNLIFIEARGGLTTSEQLLGVINQHPQGLGLTIKQLSYSINRPVSMINLCLKQLSSRKQVKIQLRGMQKLVYPYDSCNHLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ40</accession>
    <name>K9YZ40_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFZ52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0035"/>
    <dbReference type="EnsemblBacteria" id="AFZ52196">
        <property type="protein sequence ID" value="AFZ52196"/>
        <property type="gene ID" value="Cyan10605_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0035"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.37"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_3"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="49055" checksum="160432D37DD70E0D" modified="2013-03-06" version="1" precursor="true">MRLFAIFLLIVINAFFVTAEFAIVSVRKSRIDHLVMEGDIQASTVQSLQKSLDKLLSSTQLGITLSSLALGWIGEGTIALSVQYAISSLPVSENISTTLSHSFAIPISFFLLVYLQIVLGELCPKSLALLYPEQLARFLAPPISVISTIFKPFIDILNLSTRFLLKLIGVEYTGQGWYKQVTPEELQLIISTERDSSGLEAEERELLSNVFEFGDVEASEIMTPRVNIKALNLHLTCRELFQEIVKTKHSFYPVIGDSLDDIRGVIDFKDCLSILNEDPINLDILLEDFIKPVRFLPESTLLSELLAIMQQSRSKLVIIVDEYGGTSGLVTMQDLINEILGGDDSEYTEDQFSITVIDEQNFLVSAQINLEELNDLLDFDLPLTDDYQTLGGFLVYNWQKIPKQYEVFNYDHFQFTVIDTDGPRINKIKITLKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ49</accession>
    <name>K9YZ49_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217938.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0045"/>
    <dbReference type="EnsemblBacteria" id="AFZ52206">
        <property type="protein sequence ID" value="AFZ52206"/>
        <property type="gene ID" value="Cyan10605_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0045"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.47"/>
    <dbReference type="eggNOG" id="ENOG5032ZZY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2792769_0_0_3"/>
    <dbReference type="OMA" id="CIACCDE"/>
    <dbReference type="OrthoDB" id="1925645at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7623" checksum="884244849D7CF27A" modified="2013-03-06" version="1">MTIWVNQQKDGCGILQACIATKNKEAAQDCHADWLAKLTPQQKQQGWEVSLITVESWDDVPVNALKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ59</accession>
    <name>K9YZ59_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217948.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0055"/>
    <dbReference type="EnsemblBacteria" id="AFZ52216">
        <property type="protein sequence ID" value="AFZ52216"/>
        <property type="gene ID" value="Cyan10605_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0055"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.57"/>
    <dbReference type="eggNOG" id="ENOG5031GFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803799_0_0_3"/>
    <dbReference type="OMA" id="IYAVLGQ"/>
    <dbReference type="OrthoDB" id="1618615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="15509" checksum="22551B46EA65DCC0" modified="2013-03-06" version="1" precursor="true">MERGLLWLPLLVLFFWLAWSGKKEYDKVQAYQAWAEQFDKSKYDIYSVLGKKGDLITIGIPTNQGIKEQKTFSLQNLSQLNLLVKNQVVDVDNLPEKGEATLQFSLKENQTIDVPFTDINIASQWLKYLKKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZA8</accession>
    <name>K9YZA8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase, large subunit</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218003.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0112"/>
    <dbReference type="EnsemblBacteria" id="AFZ52271">
        <property type="protein sequence ID" value="AFZ52271"/>
        <property type="gene ID" value="Cyan10605_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0112"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.115"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_2_3"/>
    <dbReference type="OMA" id="GFPIKPQ"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="187"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="378"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="547" mass="59890" checksum="5473D08508DBC7E5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZC8</accession>
    <name>K9YZC8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217991.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0100"/>
    <dbReference type="EnsemblBacteria" id="AFZ52259">
        <property type="protein sequence ID" value="AFZ52259"/>
        <property type="gene ID" value="Cyan10605_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0100"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="SITICEN"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="202"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="38574" checksum="7129514AA7FF9271" modified="2013-03-06" version="1">MTTDSGANTSDGGDNQNSKRGDILIVDDQIENIQFLSTMLMDNGYEVRQVLSGKQALKVVDYDPPELILLDIMMPEIDGYEVCRQLKSNSRTCQIPIIFLSAKQQLSEKIKGFKVGGVDYITKPFVVAEVVCRLETHLKIYRYQNLLNQEIVARKKVEQQLLIANQKLEQIANIDGLTGVYNRRYFNDLLSKEWYRLCREKQPLSMIMVDIDCFKEYNDTYGHLQGDEVLKAIASTLKSSLQRSSDFVARYGGEEFVILLPNTDLQGSITICENISLKIMELAIPHRGSSASNSITISMGVHCLIPSAKINPYTLIDKSDDALYLAKKEGRNCFRYSVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZR3</accession>
    <name>K9YZR3_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Cyan10605_0293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218173.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0293"/>
    <dbReference type="EnsemblBacteria" id="AFZ52441">
        <property type="protein sequence ID" value="AFZ52441"/>
        <property type="gene ID" value="Cyan10605_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0293"/>
    <dbReference type="HOGENOM" id="CLU_2232118_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="11431" checksum="8572E0745CA7ABD1" modified="2013-03-06" version="1">MITKNFGSFEVTGNFSLVNNNSNLLQTSLNDTTTITIDGREVLIIKGQTTLNLGTEQMTVDGDISTNIRRDAIAQRHFVIEIFSGEASFSAGSQLGGRGIELHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z038</accession>
    <name>K9Z038_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218302.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0427"/>
    <dbReference type="EnsemblBacteria" id="AFZ52571">
        <property type="protein sequence ID" value="AFZ52571"/>
        <property type="gene ID" value="Cyan10605_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0427"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.450"/>
    <dbReference type="eggNOG" id="COG3007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131990_0_0_3"/>
    <dbReference type="OMA" id="YTGCERI"/>
    <dbReference type="OrthoDB" id="1692541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="20062" checksum="7C370BBD9FD435FC" modified="2013-03-06" version="1">MRKINVNQITEIITDIENELSRMNQLEKDIKETYEKIPQYPELTITLFESLALKLHNFYTGCERIFQIITDELNGGKPSSFDWHRRLLERMANEQNDRPGVITKNTVKQLKDYLGFRHIVRNIYGFELDIDRLETLVNNYFSVWHNFREDINNFLNWLHQLKDVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z054</accession>
    <name>K9Z054_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA sulfur modification protein DndD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218280.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0405"/>
    <dbReference type="EnsemblBacteria" id="AFZ52549">
        <property type="protein sequence ID" value="AFZ52549"/>
        <property type="gene ID" value="Cyan10605_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0405"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.428"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024631_0_0_3"/>
    <dbReference type="OMA" id="CFRYLLH"/>
    <dbReference type="OrthoDB" id="1137363at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017599">
        <property type="entry name" value="DNA_S_DndD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03185">
        <property type="entry name" value="DNA_S_dndD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="659" mass="76317" checksum="C379E3E68946E5BD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L8</accession>
    <name>K9Z0L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218462.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0592"/>
    <dbReference type="EnsemblBacteria" id="AFZ52731">
        <property type="protein sequence ID" value="AFZ52731"/>
        <property type="gene ID" value="Cyan10605_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0592"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.624"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_3"/>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="25580" checksum="1F59A18DFF3815F4" modified="2013-03-06" version="1">MVLSISLSWSNLSIPFPQQRVKIEQLSNTDLILRCQEGKQPDRVAFAELLRRYQGYVDKILYNLAPDWQDRGDLAQEIWIKVYRKINTLQDPTKFKGWLGRITTNLFYDQLRKKKRFATPISLDASITTDDDEFSWELPSDLPLPEENLTTVEFYAQLRDAIASLPDTFRTTIVLREIQGLSYEEIAEITQVSLGTVKSRIARARNRLQLLLKPYLDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P9</accession>
    <name>K9Z0P9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218034.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0145"/>
    <dbReference type="EnsemblBacteria" id="AFZ52302">
        <property type="protein sequence ID" value="AFZ52302"/>
        <property type="gene ID" value="Cyan10605_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0145"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.150"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_3"/>
    <dbReference type="OMA" id="VIRHNVP"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="456" mass="49808" checksum="1F6F6471F5B7105C" modified="2013-03-06" version="1">MSFINTFKAVERDKLVNLFILFFCALFFWMSLTSLIPTLPSYLQNIGATVKQVGYIMGCFAIGLLLSRVWLGKLADEGLQKFINYLPFPSGINNFILRFFRRFLGKLVYYPSRKVVIIIGTIVAFIAPLGYLFFDSLSELMINRAFHGVSIAAFTTGYSALVVDLSPPKQKGELIGYMSLAVPIGMAIGPAMGGFLEVYTSYEFLFLLSASCGLMALILACQIRELDSQVDKNQNISVSGEILSKESLINRDFKELIFSASFAVPALVLLLIGCLFGTLVTFLPLYIRDLGLNFNVGFFYTAAAIASFAVRFLSGRASDKYGRGLFISGSLICYILSMIFLTFVQDNMMLILSAILEGIGAGVLVPITLALISDRCSAIERGKVFAVCVSGFDVGVALGGPVLGSLILDFGYRVLFGVTALMAIAALLIFIGFSNKNIANSWKFAWGISSDLYAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q9</accession>
    <name>K9Z0Q9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218507.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0637"/>
    <dbReference type="EnsemblBacteria" id="AFZ52776">
        <property type="protein sequence ID" value="AFZ52776"/>
        <property type="gene ID" value="Cyan10605_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0637"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.673"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_3_3"/>
    <dbReference type="OMA" id="VRSAQMC"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12884" checksum="314724EB08A0F638" modified="2013-03-06" version="1">MNFNSINVQELAQILAEENQAIQLIDVREEMEAQIASIPQFKLLPLSKYEQWANKIKEEFNPELETIVICHHGIRSANMCQWLVAQGFKNVKNVVGGIDAYSIYVDNTINRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U0</accession>
    <name>K9Z0U0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">Cyan10605_0196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218084.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0196"/>
    <dbReference type="EnsemblBacteria" id="AFZ52352">
        <property type="protein sequence ID" value="AFZ52352"/>
        <property type="gene ID" value="Cyan10605_0196"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0196"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.206"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_3"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
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            <end position="178"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="206" mass="23095" checksum="5A87F9E74E762410" modified="2013-03-06" version="1">MNNFPEQEQQAEETQTKAVGKPRWYVVQVASGCEKKVKTDLEQRTNSFDLGDRVLQIRIPQSPTVKVKKDGSRIHGAEKVLPGYVLVEMILDDDAWQMVKNTPNVINFVGAEQRRAVGRGRGHVKPLPLSPSEVARIFKESEEAEPVLKIDMQVGDKILVLSGPFKDFAGEVIEVSTERNKLKALLSIFGRDTPVELEFNQVEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
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                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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            <end position="304"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52357.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127164" checksum="F3047118C277B33A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W8</accession>
    <name>K9Z0W8_CYAAP</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_0034</name>
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        </lineage>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000010480">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="10996" checksum="2BCA452321175ABB" modified="2013-03-06" version="1" precursor="true">MGIMSNSTILASSLVILSSLTIGVASGLISFYVGSESLKSVNTPPENPTQKINEQEKEVQDNKKFSIIPEQKILVKVYDYVHKQQEASKVKQSQSNSNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Exoribonuclease II</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0710</name>
    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="267"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="668" mass="76993" checksum="B40AFFC700EC7758" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y0</accession>
    <name>K9Z0Y0_CYAAP</name>
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        <submittedName>
            <fullName evidence="7">Putative CheA signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">Cyan10605_0044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0044"/>
    <dbReference type="EnsemblBacteria" id="AFZ52205">
        <property type="protein sequence ID" value="AFZ52205"/>
        <property type="gene ID" value="Cyan10605_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0044"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.46"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_6_2_3"/>
    <dbReference type="OMA" id="EANMRTE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="652"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="881"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1113"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1348" mass="151920" checksum="2A3B06BA03C8C806" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z3</accession>
    <name>K9Z0Z3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_0737</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218602.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0737"/>
    <dbReference type="EnsemblBacteria" id="AFZ52871">
        <property type="protein sequence ID" value="AFZ52871"/>
        <property type="gene ID" value="Cyan10605_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0737"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.773"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_3"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="14">
        <location>
            <begin position="241"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="858" mass="97906" checksum="284B619096DDCC0F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z118</accession>
    <name>K9Z118_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ordered locus">Cyan10605_0091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217982.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0091"/>
    <dbReference type="EnsemblBacteria" id="AFZ52250">
        <property type="protein sequence ID" value="AFZ52250"/>
        <property type="gene ID" value="Cyan10605_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0091"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.93"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_3"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02169">
        <property type="entry name" value="SMC_prok_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="551"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="439"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="725"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139411" checksum="FDFB5840F82615D0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z126</accession>
    <name>K9Z126_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0289"/>
    <dbReference type="EnsemblBacteria" id="AFZ52437">
        <property type="protein sequence ID" value="AFZ52437"/>
        <property type="gene ID" value="Cyan10605_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0289"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.299"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000765_0_0_3"/>
    <dbReference type="OMA" id="EYRPSIY"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="745"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="2350" mass="253862" checksum="231F1ABBCAE1070D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z195</accession>
    <name>K9Z195_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218707.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0844"/>
    <dbReference type="EnsemblBacteria" id="AFZ52976">
        <property type="protein sequence ID" value="AFZ52976"/>
        <property type="gene ID" value="Cyan10605_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0844"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.887"/>
    <dbReference type="eggNOG" id="ENOG5031I31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158420_0_0_3"/>
    <dbReference type="OMA" id="EVCIFLR"/>
    <dbReference type="OrthoDB" id="1921895at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="12048" checksum="3F1273578E8976BB" modified="2013-03-06" version="1">MLDRKIYQIYKEGCDVSIFLRDQQRWIEDARIIGIEGDIVTIRYEMDEDYENSSWEEFVRLDSIGAVSRKLASVPRGYTDLLVSDECPEAEQIYPRHQDQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A2</accession>
    <name>K9Z1A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218077.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0189"/>
    <dbReference type="EnsemblBacteria" id="AFZ52345">
        <property type="protein sequence ID" value="AFZ52345"/>
        <property type="gene ID" value="Cyan10605_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0189"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.199"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103720_0_0_3"/>
    <dbReference type="OMA" id="VIHYRKP"/>
    <dbReference type="OrthoDB" id="1656901at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="3">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="26529" checksum="97BD314975EFB72F" modified="2013-03-06" version="1">MAFGDQIYVWRNFHNLEGVYQHHGIDIGDGSVIHYRKPSEIVEQTSWDTFSRANPVYVREYPQGFTFIPEVVVKRAFSRLGENKYNLMFNNCEHFATWCKTGVSESQQVKDFIPTINRLDTFNLFEPLKNAFQGSNDINNSQHLLEDALGKIRVVWEQIQPQYREALTEIDTWQQVAVKALQNNREDLAREALTKKKSYEKKAKQLETELEKLAIMTENLLKNKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F4</accession>
    <name>K9Z1F4_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0255"/>
    <dbReference type="EnsemblBacteria" id="AFZ52405">
        <property type="protein sequence ID" value="AFZ52405"/>
        <property type="gene ID" value="Cyan10605_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0255"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.264"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_7_0_3"/>
    <dbReference type="OMA" id="GCALVGQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="405"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="495" mass="53306" checksum="62DC1DD74F0F47C7" modified="2013-03-06" version="1" precursor="true">MFINSRTLKREWFSNIKADILAGAVVGLALIPEAIAFSIIAGVDPKVGLYASFIIAVITAFLGGRTGSISAATGAMALLMVNLVKDHGIEYLFAATLLTGILQVLFGVFKLGKQMKYVPRAVMMGYINALGVLIFLAQLPQLTNVPSTVYLITIASLLIIYILPRFTQVVPSPLVALAVMTIATITLKLDVPTVGDMGELPTTLPIFALPNIPLNLETLNIILPYSLTMALVGLLASFLTAALVDELTDTPSDKNQEAKGQGIANIVTSFFGGMAGCGMIGQSVINVQSGGRGRLSTFSAGIFLLFAILVLQDWVKQMPMGALVAVMIMVSIGTIRWSSFKNIPRTPPTETAVMLATMLITIATRNFALGVITGIIMSTVFFSRQIAQLVFVDKVLSEDGNHRTYNVSGQIFFVSIEEFLGKFDFDELVDTVTINLTHAHLWDQGAVAAVDKVVLKFRRNGAEVKLIGLNQASATLLEKLTTQENPPIVEELITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I3</accession>
    <name>K9Z1I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217930.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0037"/>
    <dbReference type="EnsemblBacteria" id="AFZ52198">
        <property type="protein sequence ID" value="AFZ52198"/>
        <property type="gene ID" value="Cyan10605_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0037"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.39"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_3"/>
    <dbReference type="OMA" id="WHTTDDA"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11796" checksum="6ACC7DBDDA179C12" modified="2013-03-06" version="1">MSIYVGNLPYEVTSEDLMEVFAEYGTVSRVHIPTDRETGRMRGFAFVEMENDNQEESAIDALDGAEWMKRELRVNKAKPREKRDSFNRGGGQRKERFSQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K9</accession>
    <name>K9Z1K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217965.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0072"/>
    <dbReference type="EnsemblBacteria" id="AFZ52233">
        <property type="protein sequence ID" value="AFZ52233"/>
        <property type="gene ID" value="Cyan10605_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0072"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.74"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479690_0_0_3"/>
    <dbReference type="OMA" id="AMMGRQI"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="338"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="565" mass="62934" checksum="1A29836F5261CAE4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L3</accession>
    <name>K9Z1L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217970.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0078"/>
    <dbReference type="EnsemblBacteria" id="AFZ52238">
        <property type="protein sequence ID" value="AFZ52238"/>
        <property type="gene ID" value="Cyan10605_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0078"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048763_0_0_3"/>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="30426" checksum="4CE1EF56EAD378E0" modified="2013-03-06" version="1">MRRNWTRHELILAFSFYCQTPFGKLHRLNPDIIKLSKMIDRTPNAVALKLVNFSSLDPELKKRGIKGMGNYAKMDKIIFDEFHDNWEKLFLEAELLYEFYKNKDRDTSQEIYLYEPNRKIGEEIITKTKRRINQNFFRKIVLSNYNENCAICSLNYVSLLVASHIIPWSKNKETRLNPHNGICLCSIHDKAFDQGLISFDEEFKVIISPQIHKIKNNAINNYFINFNHREINFPKKFYPSSDFLSYHRNNIFIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N2</accession>
    <name>K9Z1N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217995.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0104"/>
    <dbReference type="EnsemblBacteria" id="AFZ52263">
        <property type="protein sequence ID" value="AFZ52263"/>
        <property type="gene ID" value="Cyan10605_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0104"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.107"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_1_3"/>
    <dbReference type="OMA" id="QGLCRTT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="533" mass="59409" checksum="7FD06577D2252F9C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q4</accession>
    <name>K9Z1Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional sterol desaturase/short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1007"/>
    <dbReference type="EnsemblBacteria" id="AFZ53136">
        <property type="protein sequence ID" value="AFZ53136"/>
        <property type="gene ID" value="Cyan10605_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1007"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1065"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623925_0_0_3"/>
    <dbReference type="OMA" id="WRHHFDD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="419" mass="47920" checksum="16F308526F2D3880" modified="2013-03-06" version="1">MGHTEVLEIVISSALAIAAPLVIALCSVIWVELVRDVYHFLAHVWQPLYRLHSWHHRIFKPDLSVNSEAIYRQANWYNDLPESLVMLTFSFIYAFTVIQTQWINPDYQWLVWTGSFYTLTFTAGAIARGLGVPYADAITDVTHRQGDFTNIPANLFVNRPYHWRHHFDDQNAYFCGTITVIDRIMGTALSLKGKKVIVTGANGTLGQALIKQLYLKGAKITALTSQEKELFISVKNQQIPIKTVTWQIGRESELNQLLTKTDILIINHGINVHGEKSAEAIEKSYEVNTFSGWRLMELFLDTVKTNQDKATKEIWVNTSEAEVNPAFSPLYEMSKRTMGELVTMKRVNAPCIIRKLILGPFKSNLNPIGIMSAEWVAQQIVNLAVRDFRDIIVTINPLTYMLFPIKEFTTANYFRWFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S7</accession>
    <name>K9Z1S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218266.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0391"/>
    <dbReference type="EnsemblBacteria" id="AFZ52535">
        <property type="protein sequence ID" value="AFZ52535"/>
        <property type="gene ID" value="Cyan10605_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0391"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560407_0_0_3"/>
    <dbReference type="OrthoDB" id="1781304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="171" mass="19120" checksum="E373320D4797FE3B" modified="2013-03-06" version="1">MVENNNNHQEEKHLESEIFTDVVTNVVGNLDEVFDSTENILTSQSLPFTNITPDKTHIQPISATLTHVQTEVELELPIHLPVVHLGKPNDHTPPDIDLSGFPHSQIVSRTHAKIFQEGDDFYIEDIGSANGTYINHAPLPTGNRHRLKNGDRIALGKEDKVSFIFQLKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z2</accession>
    <name>K9Z1Z2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218341.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0468"/>
    <dbReference type="EnsemblBacteria" id="AFZ52610">
        <property type="protein sequence ID" value="AFZ52610"/>
        <property type="gene ID" value="Cyan10605_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0468"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_3_3"/>
    <dbReference type="OMA" id="CFGTIAQ"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="285" mass="31806" checksum="885ABB4910293184" modified="2013-03-06" version="1">MNKILAIGEALFDFLPHKKVLGGAPVNFSVNCVQLGAEVTLLTRIGQDILGAEIVKNLHQKGVSSDYIQWDQEKETGKVMVNLTKSGEPSYFIKENVAWDYLALDHNLLNNLHNYQVLYFGTLAQRNTVSRQTINTIISQFKGIKFLDLNLRNPIIDQQIILQSIYQTNILKLNLFEAEYLINHLNFDRNLSTWLNNYQLDLIVLTQGEKGTKWIDKTGEYSGEISRAKKNINADSVGAGDGVSAAIITGYLQGLKPLEIIAKANKIGAYIASHSGAIVILNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z275</accession>
    <name>K9Z275_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219030.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1180"/>
    <dbReference type="EnsemblBacteria" id="AFZ53301">
        <property type="protein sequence ID" value="AFZ53301"/>
        <property type="gene ID" value="Cyan10605_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1180"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1246"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="356"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="572" mass="63845" checksum="5E5802951185F0B5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E1</accession>
    <name>K9Z2E1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8 9">Elongation factor Tu</fullName>
            <shortName evidence="8">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tuf</name>
        <name evidence="11" type="ordered locus">Cyan10605_0409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218284.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0409"/>
    <dbReference type="EnsemblBacteria" id="AFZ52553">
        <property type="protein sequence ID" value="AFZ52553"/>
        <property type="gene ID" value="Cyan10605_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0409"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.432"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_3"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="10"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="44651" checksum="BE6ACB873A0BEA02" modified="2013-03-06" version="1">MAREKFERTKPHVNIGTIGHVDHGKTTLTAAITLTLAAAGQAKARKYDEIDAAPEEKARGITINTAHVEYETPDRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPNLVVFLNKQDQVDDEELLELVELEVRELLSEYGFDGDNIPIVAGSALKAVEQMTSNGATQKGENEWTDKIWALMDEVDAYIPTPERDIDKPFLMAVEDVFSITGRGTVATGRIERGKVKVGETIEIVGIRDTRSTTVTGVEMFQKTLDEGMAGDNVGVLLRGVQKDDIERGMVLAKPGSITPHTKFEAEVYVLKKEEGGRHTPFFPGYRPQFYVRTTDVTGTISDFTADDGSAAEMVMPGDRIKMTVELICPIAIEQGMRFAIREGGRTIGAGAVSKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I5</accession>
    <name>K9Z2I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218673.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52942">
        <property type="protein sequence ID" value="AFZ52942"/>
        <property type="gene ID" value="Cyan10605_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0809"/>
    <dbReference type="eggNOG" id="ENOG502ZCIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828243_0_0_3"/>
    <dbReference type="OMA" id="LFKAYQL"/>
    <dbReference type="OrthoDB" id="1110541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="40240" checksum="53FC1D8C5C8348A9" modified="2013-03-06" version="1">MLKKIVSFLNQDISTLTQNNSQKEDISENSINIHNQALSEAKILASIAKTIDNPNFQQSDFKFYLQIKSLFARNKESYQGLETSAELLRLAVKAQSNFLKIEQTELRYRSTKQQEYYEFVLNFLGEKFGDDDNNNDLENNQIVAKKRQENKYSPEEFKQQIRTKLEEIKPTIKTEQGREALEDYTESLEGLAEEKDIGLKLLYLFKKFNLTDFSVLRVISDMVTYLQDKNMQNMKAMQDLVVKNEDVFIKLGRIIGVPKTKETPDTYARLLQYLALSKKHEQTREQFIKLIQVLKPWQGFYRTITDIREQYSANQYNLPEEFTQEIPGLSIYENYQQYINIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L0</accession>
    <name>K9Z2L0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoadenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">PAPS reductase</shortName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">PAPS sulfotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ordered locus">Cyan10605_0667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0667"/>
    <dbReference type="EnsemblBacteria" id="AFZ52805">
        <property type="protein sequence ID" value="AFZ52805"/>
        <property type="gene ID" value="Cyan10605_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0667"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.703"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_3_0_3"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="29341" checksum="A5F12BC98F03A9A4" modified="2013-03-06" version="1">MYQLPNTHFELDLKNINEKLAQANASQIVSWAKAEFGSHLVLSTSFGIQSAVMLHLVTQVVPDIPVIWIDTGYLPKETYLFAEELTNKLNLNLKVYQSHLTPARMEAIYGKLWEKKDVESLNLYDRIRKVEPMQRALKELSAKAWLAGLRQNQTQFRKQLGYVNQQGEQYKILPILRWNSRDVYEYLKEYNLPYHPYFDQGYVTVGDWHSSRPLSVDDDHERDTRFHGLKQECGLHLPTSKEEAQSLDSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M6</accession>
    <name>K9Z2M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0850"/>
    <dbReference type="EnsemblBacteria" id="AFZ52982">
        <property type="protein sequence ID" value="AFZ52982"/>
        <property type="gene ID" value="Cyan10605_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0850"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617806_0_0_3"/>
    <dbReference type="OMA" id="NLVEMVC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="451" mass="51661" checksum="1378B011F38A95D0" modified="2013-03-06" version="1">MNFFILKMDGIFEPDIAETAEILKFDRILVLKFKYNHVSLKNITEILGSTKVEILYQYNSSGHNGKEKSELIYDLLDSPLTTYAWKKAPEIIKISSKKQLEKLGILEDIEKVFFLDLTKSLVIVPLFKKRISNNINKPLILGLYIIQNNKEKRWSNAEIELAKWMAKKITNSIVNEQAFLKVQSLVNERTSQLQVSLEVQAKLGQKLRNYVDELRRVNKIKDEFIASLSDALKTPLANMKMGIKMLKLLNKNEQSIRYLDILADECEKEINLVNNLLALQTLESNNIDVESQKIYLQPLLGELYNFFSQELHYKQINLVIDSSLDYLYTDLNSLNLILRELINNACKFSHEDTDIILRIYEQNSDNIIEVTNCGFPISIAEESLIFQPFYQGSRVENVTNSGTGLGLALVQSLVQNLNGIITVESNPSSQTDRFLNTFVITFPNFGKVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q0</accession>
    <name>K9Z2Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin (2Fe-2S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218581.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0714"/>
    <dbReference type="EnsemblBacteria" id="AFZ52850">
        <property type="protein sequence ID" value="AFZ52850"/>
        <property type="gene ID" value="Cyan10605_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0714"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.748"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_7_3_3"/>
    <dbReference type="OMA" id="TTCAVRI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13975" checksum="A380FFF693FEB4A2" modified="2013-03-06" version="1">MTKTYKVTIHHRQENRIQTIEVPEDQYILATAEKQAVEPPFSCRNGACTTCAVRVLEGKLYQPEAMGLSPELQRKGYALLCVSYPRSDLVVETQDEDEVYELQFGRYFGRGKVRFGIPIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z338</accession>
    <name>K9Z338_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218731.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0870"/>
    <dbReference type="EnsemblBacteria" id="AFZ53000">
        <property type="protein sequence ID" value="AFZ53000"/>
        <property type="gene ID" value="Cyan10605_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0870"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147397_1_0_3"/>
    <dbReference type="OMA" id="FWYDQDE"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11716" checksum="D54042535D37A38D" modified="2013-03-06" version="1">MINPDNLFDNIPSLVEGEDFSELLNCRNVVIERIVSSKNPDNKVYCQEQDEWVILIKGKAQLRIKDDIVNLKAGDYLFIPAMTPHQVLTTSNNCLWLAIHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E0</accession>
    <name>K9Z3E0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ordered locus">Cyan10605_1593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219428.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1593"/>
    <dbReference type="MEROPS" id="M17.A03"/>
    <dbReference type="EnsemblBacteria" id="AFZ53701">
        <property type="protein sequence ID" value="AFZ53701"/>
        <property type="gene ID" value="Cyan10605_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1593"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1692"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_5_1_3"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="492" mass="52271" checksum="7FA1C0D5B6E75B19" modified="2013-03-06" version="1" precursor="true">MDIKISNINKLDWSGSALALSFFADDNLSLTEELNQLDQKLGNTISELIAETEFTGKEGVSAIARVGGDSAIKKIIIIGLGKPEDVNLDTFRQAGGNIARIAKQGKVAKLGVAINCDNYEDEILAQVISEGIILASHQDNRFKSEPEESKINLDTVELLGLFASESAITKAQNIASGVILARELVNSPANDINPVTMAEMVQNLASEHNLELTILEQADCEKLGMGAFLGVAKASDLPPKFIHLVYKPQGTAKRKLAIVGKGLTFDSGGLNLKVSGSGIETMKMDMGGAAATFGAAKAIALLKPEVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYADKLGADAMVDLATLTGACIVALGNDIAGLWTTEDKLANELKIAAEAGGEKFWQMPMESKYFEQMKSPIADMKNTGTRAGGSITAALFLQQFVKDTPWAHLDIAGPVWTDKPNAVNNEGGTGFAVRTLVNWVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F7</accession>
    <name>K9Z3F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein insertase, YidC/Oxa1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218991.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1140"/>
    <dbReference type="EnsemblBacteria" id="AFZ53262">
        <property type="protein sequence ID" value="AFZ53262"/>
        <property type="gene ID" value="Cyan10605_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1140"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1207"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038573_0_0_3"/>
    <dbReference type="OMA" id="KITPVMI"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="381" mass="42586" checksum="E39A3EDFAF2C401B" modified="2013-03-06" version="1">MDFGIGFISTNIMLPILDFFYGIVPSYGFGIIALTLVVRFAVYPLSAGQIRNMRKMRITQPLMKERQAEIQKKYKDNPQKQQEEMGKLMQELGNPLAGCLPLLLQMPILFALFATLRGSPFADINYTVDVQIFPQEQIERIQPQPFATKAQNVFINDGVHNRISAILPAGNKLVVGEKEQIELQTTEGKSLQSIVSEYPDSHLQPRWEVTKGQERVMVTEDGEIQALSTGDATIQITIPGIAADKGFLFIKALGRVGVVGDDGTINWDILGMVIFFGFSIYLNQELSGGGQNTGGNEQQQTVNKITPVIFSGMFLFFPLPAGVLMYIVIANVFQTIQTLILMREPLPENLQKIVAEREKANKTRDNLPFEKKNLKKKEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K3</accession>
    <name>K9Z3K3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxysome shell vertex protein CcmL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Carbon dioxide concentrating mechanism protein CcmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmL</name>
        <name evidence="5" type="ordered locus">Cyan10605_0826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Probably forms vertices in the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Has been modeled to induce curvature upon insertion into an otherwise flat hexagonal molecular layer of CcmK subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homopentamer. Interacts with full-length CcmM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The tight homopentamer forms a pore with an opening of 4-5 Angstroms in diameter which opens into a wider tunnel at the base of the truncated pyramid. The pore is positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CcmL/EutN family. CcmL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218689.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0826"/>
    <dbReference type="EnsemblBacteria" id="AFZ52958">
        <property type="protein sequence ID" value="AFZ52958"/>
        <property type="gene ID" value="Cyan10605_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0826"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.869"/>
    <dbReference type="eggNOG" id="COG4576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148498_0_1_3"/>
    <dbReference type="OMA" id="GAGINEW"/>
    <dbReference type="OrthoDB" id="1832681at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00858">
        <property type="entry name" value="CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046387">
        <property type="entry name" value="CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="4" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="1 4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11007" checksum="2397150E1CFC86E0" modified="2013-03-06" version="1">MQIAKVCGTVVSTHKSRTLTGVKLLLVQFLDVSGNPLPQYEVAGDTVGAGINEWVLVTRGSSARKETGNEERPIDAMVVGIIDTVTVASELLYSKKDAERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L0</accession>
    <name>K9Z3L0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219436.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1601"/>
    <dbReference type="EnsemblBacteria" id="AFZ53709">
        <property type="protein sequence ID" value="AFZ53709"/>
        <property type="gene ID" value="Cyan10605_1601"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1601"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1700"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_3"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="99"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="544"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="395"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="419"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="657" mass="73255" checksum="286AAF4B9F286533" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L9</accession>
    <name>K9Z3L9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219066.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1218"/>
    <dbReference type="EnsemblBacteria" id="AFZ53337">
        <property type="protein sequence ID" value="AFZ53337"/>
        <property type="gene ID" value="Cyan10605_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1218"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1285"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_3_0_3"/>
    <dbReference type="OMA" id="WLVNPQQ"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="21446" checksum="7DF728EE9F1E5182" modified="2013-03-06" version="1">MATVINVESLNQLTSEAFYQLCLANPDIPMEKSPQGELIIMSPVGGESGNREANLIADLIFWNRQYKLGQVFSSSTIFKLPNGGDRSPDVAWVSQSKWDSLTAEEKKKFPPICPDFVMELRSESDRLKPLQEKMEEYLNSGLKLGWLINPQDREVEIYHHQKPRTLVKMPCVLSGEEILPNFALEVDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R6</accession>
    <name>K9Z3R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219573.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1743"/>
    <dbReference type="EnsemblBacteria" id="AFZ53846">
        <property type="protein sequence ID" value="AFZ53846"/>
        <property type="gene ID" value="Cyan10605_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1743"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1850"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061753_0_0_3"/>
    <dbReference type="OMA" id="GAHCCTN"/>
    <dbReference type="OrthoDB" id="1053406at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="33599" checksum="2E584C4854C0A8E9" modified="2013-03-06" version="1" precursor="true">MKYSTIFGTGAYFLISFSLISSFLPDKVLAETQIKNQLELTNETPAFQGKRLTEGDLSIEIDFQPYNFESNDNNLKYRLFYQGKEKLKASKETFFSQVYFQPSEKDNPYPYIVIETYSGGAHCCTSFYIYTWLDGEFVETSIENLNSGGGVFKDLKGDNSLQFVTNDNSFLYAFSSYAGSYPPSLIYDVGKGELIENTRNYPNYLRETADNMLTALQEGIANDYEVNGVLAGYVAQKILLDEYEEGWQFMLENFDRNDTTGLTIYNAELEEVGQHPDFPTALKAFLQERGYLKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U0</accession>
    <name>K9Z3U0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218961.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1108"/>
    <dbReference type="EnsemblBacteria" id="AFZ53230">
        <property type="protein sequence ID" value="AFZ53230"/>
        <property type="gene ID" value="Cyan10605_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1108"/>
    <dbReference type="eggNOG" id="ENOG50347UZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2368160_0_0_3"/>
    <dbReference type="OrthoDB" id="1991404at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="11332" checksum="5923CBCBC4BFC588" modified="2013-03-06" version="1">MKDNRKQIHIGDAVKVKGKLYLVWDIKGNHIFGRQFTFTKTGRFQYYQDRIFSVNICQLANQKEKQIINEQRKQASIQQKSYSPIGDNYTRHLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z426</accession>
    <name>K9Z426_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219226.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1384"/>
    <dbReference type="EnsemblBacteria" id="AFZ53497">
        <property type="protein sequence ID" value="AFZ53497"/>
        <property type="gene ID" value="Cyan10605_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1384"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844429_0_0_3"/>
    <dbReference type="OMA" id="INQAMET"/>
    <dbReference type="OrthoDB" id="1812444at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="36231" checksum="B99E07756894D507" modified="2013-03-06" version="1">MADAQVMEQNIDESVEKLEELLTALDLANNQMTEFTQQLEETNQSLDNCLEEVTNSLETASSEFENSKKEFTEDSEAMITELTGLQAALTQLQAKLEEISQSVEEKETEVETEIDNQQGELDNFFAQLSQTFADLAEGISNLEDSLANSNSEAEEFFNSFSDNTSNLQGDLESTQEETEAKFEETATNIGETNKGEMDSLLTDFSGNLMGEQLSELTSQLENLTSSFDDLLSSFEDENMNLADELKERLNEIMTNSSEYAGQTTKDELTQTFEQAMEDAVSSLASEMVEQISMTTVGTSVTASISPILPQIAAAKIAIGAINAVLDAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z436</accession>
    <name>K9Z436_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ordered locus">Cyan10605_1395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219236.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1395"/>
    <dbReference type="EnsemblBacteria" id="AFZ53507">
        <property type="protein sequence ID" value="AFZ53507"/>
        <property type="gene ID" value="Cyan10605_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1395"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1473"/>
    <dbReference type="eggNOG" id="COG0109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_2_3"/>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="OrthoDB" id="1875497at2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="324" mass="36506" checksum="E5914EB5D71E59D3" modified="2013-03-06" version="1">MIGTSISPRNENFWQVIQSYYLLTKPRIIPLLLITTTASMFMAGKGTVDPLLLIMTLLGGTLAAASAQTFNCVYDQDIDYDMKRTRKRPIPSGRVQSNHAIIFGIFLAILSFSILVIAVNLLSALLAMTGIVFYMLIYTHWLKRHTSQNIVIGGAAGAIPPLVGWAAVTGDLSWSAWALFTLIFLWTPPHFWALALMISDDYAQVGVPMLPVVEGVESTVKQIWIYTWITFAFSLIFIYPLHSAGFVYFSFALILGLTFIYKAWQLLQQPEKKDCAKSMFKYSILYLMLLCSGIVVDSWQLSHQLTDSFDRQIMALLNLWLNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A9</accession>
    <name>K9Z4A9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219154.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1310"/>
    <dbReference type="EnsemblBacteria" id="AFZ53425">
        <property type="protein sequence ID" value="AFZ53425"/>
        <property type="gene ID" value="Cyan10605_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1310"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1383"/>
    <dbReference type="eggNOG" id="COG5439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136789_0_0_3"/>
    <dbReference type="OMA" id="DENFRVW"/>
    <dbReference type="OrthoDB" id="1678832at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13390" checksum="8D76A7C949210558" modified="2013-03-06" version="1">MQDKKIQGEDYLVEFNADNWAVIFKGELSLSGPQEYSPIKDLLESVADNDPENMTINLKELHFLNSSGISMLSKFVISLRKKKKLQLIILGSEQIPWQKKSLKNLQKFLPGLKLEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C6</accession>
    <name>K9Z4C6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219719.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1896"/>
    <dbReference type="EnsemblBacteria" id="AFZ53994">
        <property type="protein sequence ID" value="AFZ53994"/>
        <property type="gene ID" value="Cyan10605_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1896"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2012"/>
    <dbReference type="eggNOG" id="COG3961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_3"/>
    <dbReference type="OMA" id="EQRYNDI"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="7">
        <location>
            <begin position="204"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="8">
        <location>
            <begin position="413"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="573" mass="62845" checksum="7D869092E843A76F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E1</accession>
    <name>K9Z4E1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein Cyan10605_1341</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219184.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1341"/>
    <dbReference type="EnsemblBacteria" id="AFZ53455">
        <property type="protein sequence ID" value="AFZ53455"/>
        <property type="gene ID" value="Cyan10605_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1341"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1415"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_3"/>
    <dbReference type="OMA" id="TRWVAED"/>
    <dbReference type="OrthoDB" id="1033276at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="365" mass="39227" checksum="E394ED905FF0FFEE" modified="2013-03-06" version="1">MMLFKNDIKIYSQLEQGKRWLNKYINCLPLFTCTLGFTNTALIEGISTAGATVDSRRYTALADAEFLVKGVQTKSIFPLPPLDVGISPTFISRAVVEKFNLPVIIFNAGLLQSPSVANIDLGGKSANCVSTGKALPLDTVKHLYQEGLKWGKILAQQAEDSYLILSECVVGGTTTALAVLTALGIEAQDKVNSSHPVCNHQQKWEIVSRGLKNSNYNFNDPLEIIAAVGDPMQIVVSAIALSASTTVGVMLAGGTQMLAIYALIKALNRYYNLETCLDNIIVGTTRWVAEDTTGDTVGLAQLIGDVSVCATQLNFSNSRFPSLQVYEQGFVKEGVGAGGSAIASHLLGMTKEELLSAIEKIILQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F3</accession>
    <name>K9Z4F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219744.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1923"/>
    <dbReference type="EnsemblBacteria" id="AFZ54019">
        <property type="protein sequence ID" value="AFZ54019"/>
        <property type="gene ID" value="Cyan10605_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1923"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2044"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_4_3"/>
    <dbReference type="OMA" id="FIRGNPF"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041518">
        <property type="entry name" value="Bac_GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18034">
        <property type="entry name" value="Bac_GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_GH3_C" evidence="5">
        <location>
            <begin position="383"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="530" mass="58970" checksum="DB68B746ED1AAA4E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I7</accession>
    <name>K9Z4I7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219779.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1959"/>
    <dbReference type="EnsemblBacteria" id="AFZ54054">
        <property type="protein sequence ID" value="AFZ54054"/>
        <property type="gene ID" value="Cyan10605_1959"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1959"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2080"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_3"/>
    <dbReference type="OMA" id="MYAVAEG"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="732" mass="81369" checksum="0BCF6B54D08FB70C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J9</accession>
    <name>K9Z4J9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219239.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1398"/>
    <dbReference type="EnsemblBacteria" id="AFZ53510">
        <property type="protein sequence ID" value="AFZ53510"/>
        <property type="gene ID" value="Cyan10605_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1398"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1476"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_11_3_3"/>
    <dbReference type="OMA" id="NWADLTY"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="32826" checksum="A55FBCE752FA58D5" modified="2013-03-06" version="1">MKINQFLRNYEQGIRQFQGINLQSATLSESVLVAVDLQYAKLIGADFSRCFLTKSNFSHAQLNWADFTYSKLSEAVFNGADLTKANLTGAFMVRSHLIKTQLSAANLSHSNLRNGNLAEVNLCGASLYRVNLREAFIGNSNLNWSNFQEARLSKANMKQSSAYQANFTRSFMKEVNLSNSNLTEANLYGARLSRSNLQNANLQNANLREAILVGADLRGADLRGANLQNADLQMANLDGAIFDDTNLSQANLTGVNINHTSFVNSCLDNTILSETLSKMLNFELKKNYRVNMAINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K1</accession>
    <name>K9Z4K1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219836.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2017"/>
    <dbReference type="EnsemblBacteria" id="AFZ54111">
        <property type="protein sequence ID" value="AFZ54111"/>
        <property type="gene ID" value="Cyan10605_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2017"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_1_3"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="35212" checksum="6C9B5247E089E2DC" modified="2013-03-06" version="1" precursor="true">MIKLFSFLLFFSLIIPLNSCQKQSLTVENNIINNDYLISVTDASNHELKFSKIPEKIVCLHLSCIDILAELNHPPIAVHNMLLNLAKSDIYFGEKGKNIIPISGYGEPNLEQLLKLKPDLIVGHLAGYSSQRNTLDAIAPVFLIEIETYEDAIDNLEKFANLLNKDEEFKVAKNKFTAKLDNYKKQANNEKIVLVTNGYKGNFFIATKESLLGSVLDELTNYPWSISGNNPSAINWVSLSSEEILTINPDIIFVLVKSPSSNLLGDLRKDSFWQELKAVKNNQVYPLEEEKVGGLTTGTKSLSAFLDQIMPLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K7</accession>
    <name>K9Z4K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219841.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2022"/>
    <dbReference type="EnsemblBacteria" id="AFZ54116">
        <property type="protein sequence ID" value="AFZ54116"/>
        <property type="gene ID" value="Cyan10605_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2022"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_2_3"/>
    <dbReference type="OMA" id="AIARHEF"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939099" evidence="2">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="38236" checksum="B69CA915CD660D69" modified="2013-03-06" version="1" precursor="true">MRKISIKFILFFCTIFLIIACQNGNNQSANDTNNCQNISHDFGITEICQKIEKIAVLGSYNLAQILSLGYQPYGFGGYFGFEKGEKITNVKEIDPILGNLITTEPYNLGNANNPSLEVLSKIKPDLILGETRNQTQYNFLSQIAPNLLFKDRTIKGKWQQDLTTLATALNETEKAQTIINNYENQLNQTKADFTEIINNKNQVLFLAGNGLNDSLFMLSKNSDLGNIFSQLGFEIITISNDNSSVTMPISLESLPDIGKQADWIFILGYNTDVKNKSNSEILANQTATIKQDWQENSLTKSLPATLNNQVYFASYALWNGLNGAIASEYILEQLREFLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K8</accession>
    <name>K9Z4K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na-Ca exchanger/integrin-beta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219799.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1979"/>
    <dbReference type="EnsemblBacteria" id="AFZ54074">
        <property type="protein sequence ID" value="AFZ54074"/>
        <property type="gene ID" value="Cyan10605_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1979"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2099"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224137_0_0_3"/>
    <dbReference type="OMA" id="YGHPWLA"/>
    <dbReference type="OrthoDB" id="1554at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028059">
        <property type="entry name" value="SWM_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13753">
        <property type="entry name" value="SWM_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0401">Integrin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="8">
        <location>
            <begin position="3566"/>
            <end position="3662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2271"/>
            <end position="2294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="3948" mass="422521" checksum="EE371F661F497E72" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z525</accession>
    <name>K9Z525_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ordered locus">Cyan10605_2190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220001.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2190"/>
    <dbReference type="EnsemblBacteria" id="AFZ54276">
        <property type="protein sequence ID" value="AFZ54276"/>
        <property type="gene ID" value="Cyan10605_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2190"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2327"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_3"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="16415" checksum="CB431A68737239CC" modified="2013-03-06" version="1">MSNHNILVLHGPNLNLLGLREPSIYGHQTLEDINGILRLDGEKMQVSVTCVQSNHEGVLVDQIHQALNKYQGILINAGAFTHTSVAIRDALAGVAIPAVEVHLSNIYRREEFRHHSYIAPVAIGQISGFGANSYRLGLRALVDYLQKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z530</accession>
    <name>K9Z530_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ordered locus">Cyan10605_2153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219964.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2153"/>
    <dbReference type="EnsemblBacteria" id="AFZ54239">
        <property type="protein sequence ID" value="AFZ54239"/>
        <property type="gene ID" value="Cyan10605_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2153"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2287"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_0_1_3"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="730"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="523"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="803" mass="89203" checksum="CB39C8347F699543" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z566</accession>
    <name>K9Z566_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl diphosphate reductase</fullName>
            <ecNumber evidence="3">1.3.1.83</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Geranylgeranyl reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH</text>
            <dbReference type="Rhea" id="RHEA:26229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:75434"/>
            <dbReference type="EC" id="1.3.1.83"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geranylgeranyl reductase family. ChlP subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.83" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219614.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1785"/>
    <dbReference type="EnsemblBacteria" id="AFZ53887">
        <property type="protein sequence ID" value="AFZ53887"/>
        <property type="gene ID" value="Cyan10605_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1785"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1893"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_3_1_3"/>
    <dbReference type="OMA" id="GMCRREV"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102067">
        <property type="term" value="F:geranylgeranyl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045550">
        <property type="term" value="F:geranylgeranyl reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010253">
        <property type="entry name" value="BchP_ChlP_pln/prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011774">
        <property type="entry name" value="Geranylgeranyl_Rdtase_pln/cyn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02023">
        <property type="entry name" value="BchP-ChlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02028">
        <property type="entry name" value="ChlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="9">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="9">
        <location>
            <begin position="87"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="407" mass="44830" checksum="15D2D0ECA5BD6CA4" modified="2013-03-06" version="1" precursor="true">MTIRVAVVGGGPAGSSTAEVLAKAGIETYLFERKLDNAKPCGGAIPLCMVSEFDLPPEIIDRRVRKMKMISPSNIEVNIGQTLKDDEYIGMCRREVLDGFMRDRAAKLGANLINGTVYQLDIPSNDRDPYVLHYADHSNGTAQGEMKTLKVDLVVGADGANSRIAKAIDAGDYNYAIAFQERIRLPEDKMAYYEDLAEMYVGNDVSPDFYAWVFPKYDHVAVGTGTMKVNKAIIKDLQAGIRKRAAKRLEGGEIIKVEAHPIPEHPRPRRVVGRVALVGDAAGTVTKSSGEGIYFAAKSGRMCAEMIVEASNNGQKVPSEADLKTYIKRWDKKYGATYLVLDILQRVFYRSDATREAFVEMCADIDVQKITFDSYLYKTVVPSNPLVQMKITAKTIGSLLRGNALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z568</accession>
    <name>K9Z568_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219422.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1587"/>
    <dbReference type="EnsemblBacteria" id="AFZ53695">
        <property type="protein sequence ID" value="AFZ53695"/>
        <property type="gene ID" value="Cyan10605_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1587"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1686"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_11_0_3"/>
    <dbReference type="OMA" id="DAMAYNN"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938671" evidence="3">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="30190" checksum="3C412BF15A5BBCD3" modified="2013-03-06" version="1" precursor="true">MIRFFITLLICLSLFISPVIAEENINIPTEAQLQAGEEIARQAIEATEKGDFIQAEKFWTELINEFPSNPAVWSNRGNARVSQNKIAEAIGDYNESIKLAPDAPDPYLNRGVAYEGLGKYQDAIADYQKVLELDPEDAMAYNNLGNANAGLENWDEAVKYYHKATELAPNFAFASANESLALYQLGKKQEALTKMRNIVRKYPMFPDMRAALTAVLWEEGKQGEAESNWVATVGMDSRYKNVEWLKEVRRWPPKMIVALENFLTLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A0</accession>
    <name>K9Z5A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2233"/>
    <dbReference type="EnsemblBacteria" id="AFZ54319">
        <property type="protein sequence ID" value="AFZ54319"/>
        <property type="gene ID" value="Cyan10605_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2233"/>
    <dbReference type="HOGENOM" id="CLU_1802915_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16544" checksum="7C3D807A50D52F75" modified="2013-03-06" version="1" precursor="true">MKPNLKAQRIRIQSGTVRSHYRLVFSLFVLILICLFTGLMNFSVAQDNQSSDTLSVLAKRCRYYYIRSRAGDSRATYLLISKNEGKNTLTGLEKCLNVLNEYLVSDSITNDEKKVYQQVYDHLFILKDKLPKDEETNNPNNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C4</accession>
    <name>K9Z5C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene-hopene cyclase</fullName>
            <ecNumber evidence="6">5.4.99.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.17" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219482.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1649"/>
    <dbReference type="EnsemblBacteria" id="AFZ53755">
        <property type="protein sequence ID" value="AFZ53755"/>
        <property type="gene ID" value="Cyan10605_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1649"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1751"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019345_0_0_3"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="260889at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051007">
        <property type="term" value="F:squalene-hopene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="315"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="640" mass="72542" checksum="65992AA78C598376" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E5</accession>
    <name>K9Z5E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54364">
        <property type="protein sequence ID" value="AFZ54364"/>
        <property type="gene ID" value="Cyan10605_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2280"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2422"/>
    <dbReference type="HOGENOM" id="CLU_1913566_0_0_3"/>
    <dbReference type="OMA" id="NIVERWE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15361" checksum="DE4BB897AC7EBE11" modified="2013-03-06" version="1">MMKRRGGFRQGAGRKPMWQNGETQTIRVPVALKDDLITIGRELDQGRGVIMGKTCSQLENIVERWEAKCEENQGQEWDNIRQLILEIKEVLAQRQNKGRMGNRHQHQQGQCHKKQMRRGNPNWVDTEADIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G5</accession>
    <name>K9Z5G5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine--glyoxylate transaminase</fullName>
            <ecNumber evidence="7">2.6.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.45" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220108.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2300"/>
    <dbReference type="EnsemblBacteria" id="AFZ54384">
        <property type="protein sequence ID" value="AFZ54384"/>
        <property type="gene ID" value="Cyan10605_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2300"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2443"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_3"/>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050281">
        <property type="term" value="F:serine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="363" mass="39391" checksum="20EFA6A6C16C6CE1" modified="2013-03-06" version="1">MQDKLMLMIPGPTPVPERVLLAMAQHPIGHRSGDFSKIIAELNENLKWLHQTKNEVCTLCASGTGAMEAGIINFLSKGDRVLVGNNGKFGERWGKVAKAFGLDVEEITAEWGKGLNPDDFKAKLEADTEKKIKAVIVTHSETSTGVLNDLETINKYVKAHGEALIIVDAVTSLGAVNVPVDEWGLDVVASGSQKGFMIPPGMGFVAVSEKAWKAYETSNLPKFYLDLGAYKKANAKDSSPFTPPINLMYGLKAALEMMKEEGLENIFARHKYLTQITREGVKALGLPLFASDNDAALAITAVAPDNHDAEAIRSAMRKRFDIALAGGQDHLKGKIFRIGHLGFVSERDVYTALSALKEVISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K1</accession>
    <name>K9Z5K1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54017">
        <property type="protein sequence ID" value="AFZ54017"/>
        <property type="gene ID" value="Cyan10605_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1921"/>
    <dbReference type="HOGENOM" id="CLU_936025_0_0_3"/>
    <dbReference type="OMA" id="ALIFINW"/>
    <dbReference type="OrthoDB" id="1922616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="35052" checksum="831DB802DDCDF2D5" modified="2013-03-06" version="1">MSVHPLIKKIIQNLDLDLGAELRRYEKNTVDSDILIPELIETESIDLPSNSSSLVYHLPLDNYDEDGEDDEDEPIPVASRLISRDRASLLDLILTPWGIFGIIMFFGTNILIFLGINNFNFNSSNQKAEIVDQSRKDQQIINEVTPEIEQKDEQIIDEQIKEENEQKSPPLPSSLPSVDNANIKNSIPASPYPDLKTALMKEINNNELSESSLPLPPPLSEENSNTLPNQDEPIEANSSSQNNQKKEYIILTNYENMTQFNNIKKEIPNAFITNIEGEMKIQLGVFNTEIEAKTKSQQWQKQGIKTFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M4</accession>
    <name>K9Z5M4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220215.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2409"/>
    <dbReference type="EnsemblBacteria" id="AFZ54491">
        <property type="protein sequence ID" value="AFZ54491"/>
        <property type="gene ID" value="Cyan10605_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2409"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_3"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="6">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc-hook" evidence="5">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="163"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="311"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="535"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="640"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="746"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1007" mass="118120" checksum="9FCF12C9BF25FB4E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P5</accession>
    <name>K9Z5P5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219622.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1793"/>
    <dbReference type="EnsemblBacteria" id="AFZ53895">
        <property type="protein sequence ID" value="AFZ53895"/>
        <property type="gene ID" value="Cyan10605_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1793"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1901"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_3"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rmlC"/>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="21246" checksum="BA7B559898D544B6" modified="2013-03-06" version="1">MEIITTEIPEVFIIQPKVFQDDRGFFYESFNARTFQEKTGLNPNFVQDNHSHSQRNVLRGLHYQIQQKQAKLVRVINGEILDVAVDIRKSSPTFKQWVAVKLSAENQKQLWIPEGFAHGFLVLSETADVLYKTNNFYSSQYDRSIRWNDPEIDLNWNLKETPILSEKDKNAPLLKEAEIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P7</accession>
    <name>K9Z5P7_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Ycf66 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219792.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1972"/>
    <dbReference type="EnsemblBacteria" id="AFZ54067">
        <property type="protein sequence ID" value="AFZ54067"/>
        <property type="gene ID" value="Cyan10605_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1972"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2093"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628095_0_0_3"/>
    <dbReference type="OMA" id="IHRKDDF"/>
    <dbReference type="OrthoDB" id="1879253at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010004">
        <property type="entry name" value="Uncharacterised_Ycf66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07444">
        <property type="entry name" value="Ycf66_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="423" mass="47390" checksum="6B6CED391164339F" modified="2013-03-06" version="1" precursor="true">MLAYFLAILVAITSLSLYINAFIRPKIHRKDDFLWSGLGLFYALVLWICAGRITGAVLLGQCAGVAIAIAFIWENSKLRQALIAESQSNQALEGFSVLTFIAQLLAKVSQLGKKKPVVTTSPPEKPSETITTPPEEKEEISPTVASTTKEETQIKNQPTETEIKAYREEVIRDTIEEVTTPPQLEKDIAISDEGKEEQKIDTTSEDEEIEIDNADTTPDNETEKAENKPKINLIGRIRNIFRKSPAETSSKSVNDELPESLLDEIDDLEEEIDPESTAVEVEEAIANLDVTESSQEEEKDNQEVSEISQESDEEKVIEEELISDSQEEANEDIKDKSVVVEEEKENDVEEGESKITEENTEVMEENVNIESEIETTVTSQAENLVVEEQISPKTDTQEEEKEKEIPPEDTIESLDDLFPDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q5</accession>
    <name>K9Z5Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219430.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1595"/>
    <dbReference type="EnsemblBacteria" id="AFZ53703">
        <property type="protein sequence ID" value="AFZ53703"/>
        <property type="gene ID" value="Cyan10605_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1595"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1694"/>
    <dbReference type="eggNOG" id="ENOG502ZBJ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071178_3_0_3"/>
    <dbReference type="OMA" id="TRWRYGQ"/>
    <dbReference type="OrthoDB" id="1749611at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021275">
        <property type="entry name" value="DUF2854"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35551">
        <property type="entry name" value="PTHR35551"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11016">
        <property type="entry name" value="DUF2854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="20039" checksum="3080BF878F39B590" modified="2013-03-06" version="1" precursor="true">MLRKIPLALVGLTVGSILTVIGFVAYGTGNSTLNLAGFFYGIPLLLGGLALKAAELKPIPFLKETTPEVLALRKEKATATQNQLRLDVTRYRYGQEAHLDEALQRLGLSPTDDERPILTKIQEDKIDNHYALILYFDSPLIKLETWQEKQEKITKFFGPGIEAKISLAGENEIELALITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S0</accession>
    <name>K9Z5S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219445.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1611"/>
    <dbReference type="EnsemblBacteria" id="AFZ53718">
        <property type="protein sequence ID" value="AFZ53718"/>
        <property type="gene ID" value="Cyan10605_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1611"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1712"/>
    <dbReference type="eggNOG" id="COG4372">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683648_0_0_3"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18311" checksum="7BAED61C740A1DA7" modified="2013-03-06" version="1">MLEVNIPTINKQKIQDEIIVKIASFSQKNKTNNRYNNYWDSINKQIDYVQELIEVGKQRAKVRENLPQNFDKFPLILVKPFMSKSLKILRFLFKDQREVNNNVLQALEESVKINKVLLAEIQTMNSNFEEDLQVLSSINSNLKNKNKSLEKTINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W9</accession>
    <name>K9Z5W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2048"/>
    <dbReference type="EnsemblBacteria" id="AFZ54137">
        <property type="protein sequence ID" value="AFZ54137"/>
        <property type="gene ID" value="Cyan10605_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2048"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_2_3"/>
    <dbReference type="OMA" id="KPMYRYL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="38267" checksum="193C75F76C578D64" modified="2013-03-06" version="1">MEVLSQSHLRQTSHLYKGGLRGVKHLFFLLFLSGILIFSVLSCGVNNSLKDSQVSNQDCRVVQHARGETCIPLNPQRIVTLDFNSLAVILALDVKPIATWITTEIEDDFPYFQNKTDDIEVLRNSSGQPNLEKLLSLKPDLILVISHSWFEPIYDKLSQIAPTVILPWEEIKGDWKQHLQEAGRVFDQTEKANQLMDDYDNRIQELKGLMGDRPPKISFMFVADGQIVITRQKSFAGGILHELGFLNPLFTDSGDNDLPISEEILPTIDSDILFVAPLKKDDRSVIEKLQQKPLWSKVKAVQNNQVYVVDFSVWRGLNIFAAHEVLNDLEKYLVNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y3</accession>
    <name>K9Z5Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219520.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1690"/>
    <dbReference type="EnsemblBacteria" id="AFZ53793">
        <property type="protein sequence ID" value="AFZ53793"/>
        <property type="gene ID" value="Cyan10605_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1690"/>
    <dbReference type="eggNOG" id="ENOG502ZQG9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1746585_0_0_3"/>
    <dbReference type="OrthoDB" id="2156945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="17776" checksum="2E85996AEDD2CED3" modified="2013-03-06" version="1">MNNINHLFKQLHLQSTNHKKYVTLKKIGISLLWFIFWLLIYGICVFIQPELVFIPMLLNLPLATFFCIGIILQFLSIFIFHYPESYDILVKFLVLFFSFSLNFIYRNLIFQNPISLGKIIKFRAIEFLLWLIPWLITILFLGTIVRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z636</accession>
    <name>K9Z636_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219765.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1944"/>
    <dbReference type="EnsemblBacteria" id="AFZ54040">
        <property type="protein sequence ID" value="AFZ54040"/>
        <property type="gene ID" value="Cyan10605_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1944"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_3"/>
    <dbReference type="OMA" id="RCANTQF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="149"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="39271" checksum="12513A144A27B824" modified="2013-03-06" version="1">MIKCKQVQELSTQEITLPTVSTPSKVMVVDDQPLSLLHAVDLVQYQGYRVVEVNDSRQALKIAFEEQPDVILADVVMPEINGVELTKHLKLEPHTQSIPVLLMSVTEESQLRHQALKAGAEDVVLKPLDHTVLYPKLKNLAQQKRLNEVLNQTQKVLLNLATLIKAKSGYDYQSSFQLANLVRGFAEYLELPHSDIEDLVFAAYIHDIGTVSIPDYIFHKHGALTSEEKEIIHQHCVIGEQICQPLHNRPNLLKIIRHHHEKYDGSGYPDGLTMEQIPYLAQIFQLVDIYYALTKNRQSKTTYTPSSALDILEEEVIKGWRNPKLWEQFQQFIFLQLSSFCLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z637</accession>
    <name>K9Z637_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219590.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53863">
        <property type="protein sequence ID" value="AFZ53863"/>
        <property type="gene ID" value="Cyan10605_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1761"/>
    <dbReference type="eggNOG" id="ENOG5032GU5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988941_0_0_3"/>
    <dbReference type="OMA" id="SWQRETH"/>
    <dbReference type="OrthoDB" id="1998488at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="14172" checksum="89BF7C209596FB36" modified="2013-03-06" version="1">MLPKSHFPLLSDWLNLLVEFQKIFMSNSDDIDQIFSQWRKIQNYLQTEIITFEENNIDVSAFPQWQSWQRETHRYWKLINTELLFWKSSVSPSTKQKRKESVLQHLQGMIQLTINNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z658</accession>
    <name>K9Z658_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220352.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2549"/>
    <dbReference type="EnsemblBacteria" id="AFZ54629">
        <property type="protein sequence ID" value="AFZ54629"/>
        <property type="gene ID" value="Cyan10605_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2549"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2705"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114024_0_0_3"/>
    <dbReference type="OMA" id="QANPCAG"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044241">
        <property type="entry name" value="TxlA/HCF164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353">
        <property type="entry name" value="PTHR47353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="69"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="199" mass="21143" checksum="2EB095593DE9FFA1" modified="2013-03-06" version="1" precursor="true">MFKKSASFWLTLSLTSLVIPVSLVANNLRVSALENNTVIAQANPCAGKNPCASNNPCAGKNPCAGKNPCAGNNPCAGKSARNVGGPLAKELQGKPVVVDIYASWCPACKNIAPTLSQLKKQYGNKAHFVVFDVSDKAKARQAEARAKQLGLEDFFNANKSQTGSVTIVDPKTGDILSQYRNNNKLSDYTSVLNTAISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D9</accession>
    <name>K9Z6D9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">Cyan10605_2672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220469.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2672"/>
    <dbReference type="EnsemblBacteria" id="AFZ54746">
        <property type="protein sequence ID" value="AFZ54746"/>
        <property type="gene ID" value="Cyan10605_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2672"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2837"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_0_3"/>
    <dbReference type="OMA" id="SVFECEV"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10763" checksum="A0628A5544B4BA42" modified="2013-03-06" version="1">MYIIISYDIKDDKKRTKIHKILKSYGEWVQYSIFECELTETQYAKLRHRLSKLIKDDSDSIRFYSMCKCCQGKIERIGGEMPRDNTIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J4</accession>
    <name>K9Z6J4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ordered locus">Cyan10605_2739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220534.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2739"/>
    <dbReference type="EnsemblBacteria" id="AFZ54811">
        <property type="protein sequence ID" value="AFZ54811"/>
        <property type="gene ID" value="Cyan10605_2739"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2739"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2905"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_0_3"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="24051" checksum="B57C6F20C7F1D1CC" modified="2013-03-06" version="1">MEIKDLIAIGTIVAPQGLKGELKVKTDSDFPERFETAGVRWITSPSQKQPQPVDLLQGRQIPGKNIFIIKLAQVCDRNQAETLKGSTLYVEKTEKPYLEPGEYHVADLINLEVYNQQTGENIGIVIDVLSAGNDILEVKLHKQPEIKTEEKELDISKISRISKRKKVKIKKPKPVTILIPFVEEIVPIVDLENCRIEVNPPTGLLNPKEAEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L0</accession>
    <name>K9Z6L0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220492.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2696"/>
    <dbReference type="EnsemblBacteria" id="AFZ54769">
        <property type="protein sequence ID" value="AFZ54769"/>
        <property type="gene ID" value="Cyan10605_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2696"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2860"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_3_2_3"/>
    <dbReference type="OMA" id="AWIRQAW"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15384" checksum="76772F4D89789337" modified="2013-03-06" version="1">MGKKGLRVVIDTNLVLSALVFGGKVASLRYAWQTNLLIPLISKVTVTELIRVLAYPKFNLTPSEQEDLLADYIPYGETVRIPSKLPIIPPCRDSFDEPFLLLAKLGKADYLVAGDKDLLSLDGDFCCPIITTDKLFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S9</accession>
    <name>K9Z6S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase (Reverse transcriptase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2777"/>
    <dbReference type="EnsemblBacteria" id="AFZ54844">
        <property type="protein sequence ID" value="AFZ54844"/>
        <property type="gene ID" value="Cyan10605_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2777"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2949"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_10_0_3"/>
    <dbReference type="OMA" id="HESILNM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="40573" checksum="EA6E0CFB6BEA002E" modified="2013-03-06" version="1">MSNAILINGDNGQLEDWSQVNWRKAYKVVKNLRCRIFRARKLGQWKQLRRLQKLMIRSLSNLLLCVRQITQVNDGKQTAGIDKEVINTPAQRVKLVNEWKMPKAVPTKRVYIPKPNGKKRPLGIPTVRDRVAQAIVKNSLEPEWEAAFEPNSYGFRCGRSCHDAIGQCYLRLRGDSEKGGTHDKWVLDADIKGFFDNIAHESILNMIDSHPKKELIKGWLKAGFIDSGVHNLTETGTPQGGVISPLLANIGLHGLEKHIKQCNPKLGIIRYADDFVVTAKDKESLEEVLIQIKQWLSERGLEISAEKTRIVHIDNGFNFLGFNLRQYKGKLLTKPQKEKVLIGNVLYAVKTYSMESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z706</accession>
    <name>K9Z706_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219893.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2079"/>
    <dbReference type="EnsemblBacteria" id="AFZ54168">
        <property type="protein sequence ID" value="AFZ54168"/>
        <property type="gene ID" value="Cyan10605_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2079"/>
    <dbReference type="HOGENOM" id="CLU_2272712_0_0_3"/>
    <dbReference type="OMA" id="MTANING"/>
    <dbReference type="OrthoDB" id="2037080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11617" checksum="75891482E746704C" modified="2013-03-06" version="1">MSKIEEVKAQIRQGNLEEAMAIAISEAMKIEIMTANINGDDSTACHSLIDLLENEIEHQLGDKSLENIHFEELENAHNHILQNVQSLQQMFVILKQNYQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z761</accession>
    <name>K9Z761_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220703.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2922"/>
    <dbReference type="EnsemblBacteria" id="AFZ54984">
        <property type="protein sequence ID" value="AFZ54984"/>
        <property type="gene ID" value="Cyan10605_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2922"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040649_0_0_3"/>
    <dbReference type="OMA" id="RMELIFR"/>
    <dbReference type="OrthoDB" id="1483153at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="255"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="54914" checksum="16F40A2E23279E1F" modified="2013-03-06" version="1">MIISECLSIKLVDLILEAEWNSDFDDCSHSTIKAHHEWEGAIASLEKLLSTTVNTDKHFSSKQGIVISSPTPVINNLSIISHLTTVVFSPSPHQKTALMPSDNQQVFDNNQLSLININLDNNDILNQEQFCLVFTEQFSLLMVKEINYDRQDSFHFSFDPIVTEKAWLLLLNRLTKSSSYDSFKYLKESVNYLLGTSPNYKIVEIFNKNLLKHIKKQGTSDIKSSERETNHQRKQSISLKKTPIPPYPELELLQALTHEIRTPLTTIKTITKLLQKKAKLNPDLGKYLETIEQECTEQINRMELIFKAVELESKSSALNDSIHLVPTSLENILNQTIPTWQKQAQRRNIILDVIIPKKLPQIISDPAILSQILSGLMEKFTRSLPSGCHFQLVILPVGNQLKLQFLSESSFNYSHSKCLGKLLLFQPETGSLSLSNDVTRNIFHALGGKFTIKQKPNKGEILTIFLPLGNSKSYAYKVSTTHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z785</accession>
    <name>K9Z785_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3001"/>
    <dbReference type="EnsemblBacteria" id="AFZ55061">
        <property type="protein sequence ID" value="AFZ55061"/>
        <property type="gene ID" value="Cyan10605_3001"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3001"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3197"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_3"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="30"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="450"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="572" mass="63468" checksum="0DC9AC56CB0E37E4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D9</accession>
    <name>K9Z7D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220778.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55059">
        <property type="protein sequence ID" value="AFZ55059"/>
        <property type="gene ID" value="Cyan10605_2999"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2999"/>
    <dbReference type="HOGENOM" id="CLU_1882286_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15458" checksum="DB31E3DDC348FBA6" modified="2013-03-06" version="1" precursor="true">MKKLLYFASSLNLTVVLWLTSAISSVAQIPINAYYMESRMDGSTFYTTVQYMVDVDTFNDMNGVRLIVNHDLLRKNDENLNPLIVRGVEPSSISEDNLIIKSTFTSSPATEDLQPKIYTNQEDIYENNFHYFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H6</accession>
    <name>K9Z7H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220865.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3090"/>
    <dbReference type="EnsemblBacteria" id="AFZ55146">
        <property type="protein sequence ID" value="AFZ55146"/>
        <property type="gene ID" value="Cyan10605_3090"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3090"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3292"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_2_3"/>
    <dbReference type="OMA" id="THEYFRV"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="14176" checksum="099B1916B116CB3E" modified="2013-03-06" version="1">MSQINRNYAFLWDMWQSSQRIILFTENTSWQEYRNNILLQSAIERQLEILGEAARRISDDFQQENKQIPWSDIIGQRNIIAYQYEKVDQKRIWQVITVDIPNLVIELEKIIPPMPPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K7</accession>
    <name>K9Z7K7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adaptive-response sensory-kinase SasA</fullName>
            <ecNumber evidence="3">2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Synechococcus adaptive sensor protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sasA</name>
        <name evidence="5" type="ordered locus">Cyan10605_3077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220853.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3077"/>
    <dbReference type="EnsemblBacteria" id="AFZ55134">
        <property type="protein sequence ID" value="AFZ55134"/>
        <property type="gene ID" value="Cyan10605_3077"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3077"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3280"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723030_0_0_3"/>
    <dbReference type="OMA" id="AHYGQIW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02978">
        <property type="entry name" value="KaiB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01837">
        <property type="entry name" value="Kinase_SasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011649">
        <property type="entry name" value="KaiB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023527">
        <property type="entry name" value="Kinase_SasA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07689">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01248">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="44159" checksum="8FC34E5C1757352C" modified="2013-03-06" version="1">MSEFFSYTSNLNPDILQLLLFVDNRHGSQKNIEQIKEYLNGLSQDYNFHLQVLEISEYPHLVEHFKLVVTPALVKVNPPPQQTLAGTNLTAKLKKYWYKWQTSLRENRDVFHDSSEQDSLLQTCLPSFELIRLRDEIFHLKQEVDNLKQQVQFKDQMLAMLAHDLRSPLTAASIAVETIELVQNKKEIKPNHSLYQKLFQQAKNQFLIMNKMINDLLAASKDICSQLTVAPVRVNLVNITEEIVNNLQNKLSEKRQYIIKEIPQDLPPVYADPKLIRQVIINLLENAIKYSPENVPITLSIIHKTTQKVQVSVMDLGPGIPTAKKQKIFEGHFRLKRDRNEEGYGIGLSLCRQIINAHYGQIWVDNNGNQGSCFRFTLPVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N1</accession>
    <name>K9Z7N1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="3" type="synonym">rps15</name>
        <name evidence="7" type="ordered locus">Cyan10605_2514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220318.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2514"/>
    <dbReference type="EnsemblBacteria" id="AFZ54595">
        <property type="protein sequence ID" value="AFZ54595"/>
        <property type="gene ID" value="Cyan10605_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2514"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2665"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_3"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="10265" checksum="39B9E4BFDDA2EC14" modified="2013-03-06" version="1">MSLTQEKKQEIIGLYQIHETDTGSSALQVALLSARISQLTEHLKINKKDHSSRRGLLKLIGQRKRLLGYIKRQRPQDYQELIKKLGIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P2</accession>
    <name>K9Z7P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/proton antiporter, CPA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220910.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3140"/>
    <dbReference type="EnsemblBacteria" id="AFZ55191">
        <property type="protein sequence ID" value="AFZ55191"/>
        <property type="gene ID" value="Cyan10605_3140"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3140"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3347"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018415_1_0_3"/>
    <dbReference type="OMA" id="PAILMCF"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="14"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="411"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="528" mass="57239" checksum="FCF2316F49E5FA60" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S5</accession>
    <name>K9Z7S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220177.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2370"/>
    <dbReference type="EnsemblBacteria" id="AFZ54453">
        <property type="protein sequence ID" value="AFZ54453"/>
        <property type="gene ID" value="Cyan10605_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2370"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2517"/>
    <dbReference type="eggNOG" id="ENOG5032S8W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187113_0_0_3"/>
    <dbReference type="OMA" id="CICVNCH"/>
    <dbReference type="OrthoDB" id="1861179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019656">
        <property type="entry name" value="Uncharacterised_Ycf34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10718">
        <property type="entry name" value="Ycf34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9480" checksum="DDFA766B8684245B" modified="2013-03-06" version="1">MCICVNCLYVDRCNTYYAVEAQHQQPHLTESPDFEPVEPSINVNIRPQEDYIEMEWDVVGCASFTEDMGRWARLRPGEAIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z844</accession>
    <name>K9Z844_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_3321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221084.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3321"/>
    <dbReference type="MEROPS" id="M03.A01"/>
    <dbReference type="EnsemblBacteria" id="AFZ55366">
        <property type="protein sequence ID" value="AFZ55366"/>
        <property type="gene ID" value="Cyan10605_3321"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3321"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3536"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_4_1_3"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TOP_N" evidence="11">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="10">
        <location>
            <begin position="231"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="689" mass="77975" checksum="767474FEE8B1152A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z870</accession>
    <name>K9Z870_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221109.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3349"/>
    <dbReference type="EnsemblBacteria" id="AFZ55391">
        <property type="protein sequence ID" value="AFZ55391"/>
        <property type="gene ID" value="Cyan10605_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3349"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3567"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745822_0_0_3"/>
    <dbReference type="OMA" id="YTWLYPE"/>
    <dbReference type="OrthoDB" id="872525at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="391" mass="45483" checksum="657A98063CFBE951" modified="2013-03-06" version="1">MNTYSKSKSIMQIRPIQYRDLGAIARLLQERLSIEFNSRQNALLEKIQKYQSCYGLLQLTKILPWTVDQDFYVYVAEKDQQIQGLIQVYPINHNRSTWKVEQVLINHNTSLSHLLIGNCSIGSQLLRYCFEKIWEARTWVLEVNVNEKNTIGLYRENGFQPMAQITYWQCDGDTLEKLAQQEPNLPNLLPVSNADAKLIYQLDCVSMPPMLRQIFDRHVDDFKTNLWQYLTGKIQELFNHTEVVSAYVFEPQRKAAIGYFEISLCKNGNHPHKAKLTVHPAYTWLYPKLLSQMATLIKIYPSQSLILSSADYQAEREEFLEQLGATRQDHNLLMSRSVWHKLKESKSLDLSLPEVLNSLKPAHTPIPTPWTKSHWQDNPHNSQNKSADHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z872</accession>
    <name>K9Z872_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b6-f complex iron-sulfur subunit</fullName>
            <ecNumber evidence="13">7.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein</fullName>
            <shortName evidence="13">ISP</shortName>
            <shortName evidence="13">RISP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">petC</name>
        <name evidence="15" type="ordered locus">Cyan10605_2697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]</text>
            <dbReference type="Rhea" id="RHEA:22148"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="7.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cellular thylakoid membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="13">The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The Rieske iron-sulfur protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.6" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220493.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2697"/>
    <dbReference type="EnsemblBacteria" id="AFZ54770">
        <property type="protein sequence ID" value="AFZ54770"/>
        <property type="gene ID" value="Cyan10605_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2697"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2861"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_8_0_3"/>
    <dbReference type="OMA" id="KGDPTYI"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009496">
        <property type="term" value="F:plastoquinol--plastocyanin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01335">
        <property type="entry name" value="Cytb6_f_Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023960">
        <property type="entry name" value="Cyt_b6_f_Rieske"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19166" checksum="93AA702EB293B4BA" modified="2013-03-06" version="1">MTQISGNADVPDMGRRQFMNLLTFGTITGVAAGALYPVVSYFIPKSAGGTGAGIAAKDKLGNDVVASEFLASHQAGDRTLAQGLKGDPTYLIVTEDKQIASYGLNAVCTHLGCVVPWNASENKFICPCHGSQYNNEGKVVRGPAPLSLALVHADVNDDKVYLSNWEETDFRTGEEPWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z897</accession>
    <name>K9Z897_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220523.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54800">
        <property type="protein sequence ID" value="AFZ54800"/>
        <property type="gene ID" value="Cyan10605_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2728"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2894"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_1_1_3"/>
    <dbReference type="OMA" id="AYCVIHS"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="407" mass="46410" checksum="29E2CA4F8C52884D" modified="2013-03-06" version="1">MIVLEYKLNGNQYQYQAIDSAIRTAQFIRNKALRLWMDGEKVNKYDLNKYCAVLAQEYPFARQLNSTARQASAERAWSAISRFFDNCKKGIKGKKGYPKFKKNSRSVEYKDSGWKLDEKTKKHVTFTDKKGIGRLKLVGSRDIYFYNASEIKRVRLVKRADGYYCQFSVKVNVQIETQPTNKVIGLDVGLKEFLTDSEGNTVENPRFLRKSEKALNRANRQKSKKFVKGKKPQSNNYHKARNRYARKHLRVSRQRKEFAKSVAYCVIHSADLVAYEDLNVKGMVRNRKLAKSISDAGWTIFRGWLEYFGHKYGKITVAVPPHNTSQDCSNCGQKVQKSLSTRTHVCAHCGHIEDRDSNAAKNILIKALRTVGHTGTFALGDLPSWAIADRLSSNGESVNKESPTIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D9</accession>
    <name>K9Z8D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase (NADH) small subunit</fullName>
            <ecNumber evidence="7">1.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220567.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2778"/>
    <dbReference type="EnsemblBacteria" id="AFZ54845">
        <property type="protein sequence ID" value="AFZ54845"/>
        <property type="gene ID" value="Cyan10605_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2778"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2951"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_3"/>
    <dbReference type="OMA" id="DCVGTAH"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="153"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="493" mass="54561" checksum="DE4AED0F798142B5" modified="2013-03-06" version="1">MGKATGFLEFARELPVDKDPLERINNWDEFHRPLPEEKLRNQGARCMDCGTPFCHTGELINGMATGCPINNLIPEWNDLIYRGLWKEALDRLHKTNNFPEFTGRVCPAPCEGSCVLGINNPPVTIKNIECSIIDHGWDMGWVVPEPPKTRTGKKVAVIGSGPAGLSAAAQLNKAGHSVTVYERDDRPGGLLMYGIPNMKLDKEKVVLRRIKVLAAEGIKFVCNTEIGKDISPEQLLEENDALILCIGAGKPRDLPIEGRDLGGIHFAMEFLTANTKSVLNSNKEELICAKGKDVVIIGGGDTGTDCVGTSIRHGCKSVTQLEIMPKPPEVRAKNNPWPEYPKIYRLDYGQEEAAAKFGHDPRVYTTTATKFEADDQGNVAAVHTVEVEWQRNEQGRFIPQPIEGTEKRIPAQLVLLAMGFLGPEQMLLEKMGLESDVRSNIKADYGQYATNLPKVFAAGDCRRGQSLVVWAFNEGREVARECDRFLMQKTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z925</accession>
    <name>K9Z925_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ordered locus">Cyan10605_3161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3161"/>
    <dbReference type="EnsemblBacteria" id="AFZ55212">
        <property type="protein sequence ID" value="AFZ55212"/>
        <property type="gene ID" value="Cyan10605_3161"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3161"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3368"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_3"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="306"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="420"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="452" mass="49794" checksum="5BC3049C007A90EF" modified="2013-03-06" version="1">MKFSFIKLLANVIVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVKDQKFKLHLIPSGILYPDTECIIGSGTVIDPQELLEEIDQLKDLNVSTDNLFISQTAHVTMPYHRILDQAAEEKRGKYKIGTTGRGIGPTYSDKAERIGIRMLDLIHCDRYPDKIEWTINYKNAVLEKLYGLPPLDAKEVTKEYQIYAERLRPYVIDSSLKIDQAVRQKKNILFEGAQGTLLDLDHGTYPYVTSSNPIAGGACVGAGVGPTIIDRIIGVAKAYTTRVGEGPFPTELEDEIGEHLGDKGAEFGTTTGRRRRCGWFDGVIGRYAARINGLDCLAVTKLDVLDELSEIKVCVAYEIDGEICREFPTHAMKFASCKPVYETLPGWQQSTSNCRTLEELPKQALDYLKFLAELMELPIAIVSLGASRDQTIIVEDPIHGPKRALLDANGDPVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z993</accession>
    <name>K9Z993_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220678.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54958">
        <property type="protein sequence ID" value="AFZ54958"/>
        <property type="gene ID" value="Cyan10605_2893"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2893"/>
    <dbReference type="eggNOG" id="ENOG5033TAU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620875_0_0_3"/>
    <dbReference type="OMA" id="WPLAYER"/>
    <dbReference type="OrthoDB" id="1018870at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="494" mass="57732" checksum="C4FAF6F49DB06CD9" modified="2013-03-06" version="1">MNNIIANRKQNSNQIFNSKNKKERIYLGFCYQSKPSEVIEIISQKVNEYDLTKLIPLLRVEKKDKTKIGKRKKPEFYFFVAIEKGNDTQSERMYQEFQEKLLVLKYFKRNAFKSKGLSIFTHEQIKDMVAGKTYDVLDYTNPIPYETKSKENLVNDNPFEVDNISDNLSTDNNSKNYQKLLYWLSVVGSSSWQLFRKTCQILQLDNPARNLRKLKLLGHLETSADGQKIVVNSPTLVQIESNTEEKEFILCGQQNGKLINNLEKFGTVKIIEQPQKNAPSCIKFIPDNDIQLQEIIEQIKNNYYLQIYQADLVSRKLADALPHWQEWYENLSSLQGIVTSLYKWRQFDGNIFVECLTPQKTGMYQMFQGTIKNSGDNLDLSSQKPIRTVFYDADTQCFKQGDWCGLRFLAMKAIQQEIVIKYDEISKRLAIPYTQRLSQLYERSLVLASGILPSYQKTEDKNIWLIYENISLNLLQTLANKLDLNWEEKRECMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C9</accession>
    <name>K9Z9C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220717.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2936"/>
    <dbReference type="EnsemblBacteria" id="AFZ54998">
        <property type="protein sequence ID" value="AFZ54998"/>
        <property type="gene ID" value="Cyan10605_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2936"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="WIMDIEN"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="199"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="38265" checksum="63E28277DC1C4B52" modified="2013-03-06" version="1">MKKRIVILDDLEDQNQLFLRLLNNANYKVIITETESHLLDLINSKYPDLVLLSACLKDKDVYLICKKIKLLEIGESIPVIFINRDQKYFDAETMFNAGGADYINYPFSSAEILTKIASQIELQTLRQEIKEKNNQLQKLIPHYQKLKLALEKAKLELANISNKNESSILPDRDYFLQILEKEWLRGARQRSSFGDVSETNISLVLAEITDFQAYQKNHEQELVKNCIDIVSKTLNATVKRPGDLVSHFNEGKFAILLPNTDQEGAKTVAIKINQNLSELQIPHHYSEISEYLSFCFGIATAIPSQALPASVLIDVGENALYTALAQRKGDAIMLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D5</accession>
    <name>K9Z9D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220904.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3134"/>
    <dbReference type="EnsemblBacteria" id="AFZ55185">
        <property type="protein sequence ID" value="AFZ55185"/>
        <property type="gene ID" value="Cyan10605_3134"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3134"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3340"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_3"/>
    <dbReference type="OMA" id="IMATVPM"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115236" checksum="3C5BB28D77E6250E" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9I3</accession>
    <name>K9Z9I3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">minE</name>
        <name evidence="4" type="ordered locus">Cyan10605_3345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221105.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3345"/>
    <dbReference type="EnsemblBacteria" id="AFZ55387">
        <property type="protein sequence ID" value="AFZ55387"/>
        <property type="gene ID" value="Cyan10605_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3345"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3563"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137929_1_1_3"/>
    <dbReference type="OMA" id="VHDRANV"/>
    <dbReference type="OrthoDB" id="2038628at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11482" checksum="35B0A6B1C1A0295E" modified="2013-03-06" version="1">MFKEIVDTINSWTGSNKTRNQAKSRLQLVLSHDRAGINPEIITKMRQEILEVVSRYLDIDVEETEFFIQSNDRKTSLSANLPIKTFKRTQSPLNEDDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S4</accession>
    <name>K9Z9S4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">Cyan10605_3432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221190.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3432"/>
    <dbReference type="EnsemblBacteria" id="AFZ55472">
        <property type="protein sequence ID" value="AFZ55472"/>
        <property type="gene ID" value="Cyan10605_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3432"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3657"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_3"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="442" mass="46908" checksum="B6B961B404E17D00" modified="2013-03-06" version="1">MINLTHNQNSSQLVISHQAQSLQGNITIPGDKSISHRALMLGAIASGETIIKGLLLGEDPRSTAKCFQAMGAKISELNSEEVRVIGVGEKGLQEPFDVLDAGNSGTTMRLMLGLLAAQSGKFFSVTGDDSLKTRPMSRVIKPLQEMGAIIYGRNNHQNAPLAVVGQNLKPIHYHSPIASAQVKSCILLAGLMSEGKTTVTEPALSRDHSERMLHAFGGKLEIDQDTNSVTIEGGTPLQGQTVIVPGDISSAAFWLVAGAITPDSELTITNVGINPTRTGILEALEMMGADITIINERETAGEPVADLQVKTSQLKACTLSGAIIPRLIDEIPILAVAACFAEGTTIIKDAEELRVKESDRLAVMALELGKMGAKITELPDGLEITGGNPLRGAEVDSYTDHRIAMSLAIAALNAKGNTTINRAEAISISYPTFVDTLKEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA00</accession>
    <name>K9ZA00_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3127"/>
    <dbReference type="EnsemblBacteria" id="AFZ55178">
        <property type="protein sequence ID" value="AFZ55178"/>
        <property type="gene ID" value="Cyan10605_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3127"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3333"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025925_2_0_3"/>
    <dbReference type="OMA" id="WSTLLTE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="404"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="497" mass="54828" checksum="4D6BB1BFF3669910" modified="2013-03-06" version="1">MLFINFAKLRKYYMSFSQKNTPLLTQLSKLAFKQEAPFYAPGHKKGRGINSHFKALLGENVFKADLPELPELDNLFNPEGVIKEAQDLASHAFGAEYTWFLANGSTSGIIASILATCSEGDKIILPRNVHQSAIFGLILSGAEPIFINPEYDRDFDLFYNLSTTQIIKALDNNSRVKAVLLVSPTYHGICANVREIAYCLHNYNIPLIVDEAHGGHFHFHSDLPMSALEAEADVVIQSTHKVLGAMTQASMLHLQGSLVSSEKISRALQMVQSSSPNYLLLASLDSARQQMATEGESLLRNTLDLALIAREKLSKLDYLSVLNFEQKKDSFNNLDLTRLTINVSKLGLTGYEADEILNTQLNVTCELPSLKTLTFIISIGNNLDDINKLIEGLTKLEKYRKKVNQNDIFITNFPTPKLKITPRQAFYAETITLGQSQAINHISGETICPYPPGIPVIMAGELITQDAIASLQNIINHGGTITGASDSSLQTLKVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAF7</accession>
    <name>K9ZAF7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221086.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3323"/>
    <dbReference type="EnsemblBacteria" id="AFZ55368">
        <property type="protein sequence ID" value="AFZ55368"/>
        <property type="gene ID" value="Cyan10605_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3323"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3538"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_7_2_3"/>
    <dbReference type="OMA" id="ITANQIC"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7197" checksum="9C7AF854D6ED9F80" modified="2013-03-06" version="1">MSVKRKDLIKYLEGNGFYLLREGGNHSIYTNDNITIPVKRHNLFDRITANQICKQAGLDKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZE8</accession>
    <name>K9YZE8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218053.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0164"/>
    <dbReference type="EnsemblBacteria" id="AFZ52321">
        <property type="protein sequence ID" value="AFZ52321"/>
        <property type="gene ID" value="Cyan10605_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0164"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.171"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070021_0_0_3"/>
    <dbReference type="OMA" id="AEMTLHD"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="38465" checksum="107C8BDCADE6ADB1" modified="2013-03-06" version="1">MSSIAVVTIGRNEGDRLVNSLQSIKKVLPETNPIIYVDSGSTDDSVNKAEELGVIVLNLDLSIAFTAARARNTGLKYIVNHYPQINYIQFLDGDYELNPQWLDKAKKRLEENPSLAIVCGRRREKYPEKSLYNRLIDMEWNTPIGEVKACGGDALMRVSALKEVNGYKQDLICGEEPEMCIRLREKGWKIERLDLDMTYHDAAMYKFSQWWKRSIRGGWAVAEGYAMHGKPPENYMIKELKSGYLWGFIIPFSAIVLAYFTNGISLLLLLSYALLYWKIYRYRINFGDNVENAKLYAYWCVLSKFPQFIGQYQYWWKKINKQKFTIIEYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZF5</accession>
    <name>K9YZF5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="3" type="synonym">rps16</name>
        <name evidence="4" type="ordered locus">Cyan10605_0174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218063.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0174"/>
    <dbReference type="EnsemblBacteria" id="AFZ52331">
        <property type="protein sequence ID" value="AFZ52331"/>
        <property type="gene ID" value="Cyan10605_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0174"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.182"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_2_3"/>
    <dbReference type="OMA" id="KAGVWAK"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9415" checksum="05408987F2A07D16" modified="2013-03-06" version="1">MVKLRLKRLGKKREVSYRIVAMNSTSRRDGKVLEELGFYNPRNDETRLNVPAIVTRLKQGAQPTETVRSILTKAKVFEQVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZH9</accession>
    <name>K9YZH9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane adhesin like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218088.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52356">
        <property type="protein sequence ID" value="AFZ52356"/>
        <property type="gene ID" value="Cyan10605_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0200"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.209"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223909_0_0_3"/>
    <dbReference type="OrthoDB" id="881559at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040853">
        <property type="entry name" value="RapA2_cadherin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17803">
        <property type="entry name" value="Cadherin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="1593"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3957"/>
            <end position="3976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="4183" mass="438242" checksum="A71966B0ED630C17" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZI3</accession>
    <name>K9YZI3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218056.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0167"/>
    <dbReference type="EnsemblBacteria" id="AFZ52324">
        <property type="protein sequence ID" value="AFZ52324"/>
        <property type="gene ID" value="Cyan10605_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0167"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.175"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_3"/>
    <dbReference type="OMA" id="HCPYVKH"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20463" checksum="FECE59A566617C07" modified="2013-03-06" version="1">MARTPSVMLPLGTIAPDFNLPDTVSGKIISLKDFQGCKGLLVMFICQHCPFVKHVEQELAKIGHDYGSQNLGIVAISSNDAENYPDDSPANLKQMAEKLNFNFPFCYDETQEVAKAYQAACTPDFYLFDSDFRLVYRGQLDDSRPSLDIPVTGKDLRDAIASLLAGKPINPDQKPSLGCNIKWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZI7</accession>
    <name>K9YZI7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218061.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0172"/>
    <dbReference type="EnsemblBacteria" id="AFZ52329">
        <property type="protein sequence ID" value="AFZ52329"/>
        <property type="gene ID" value="Cyan10605_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0172"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.180"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_21_1_3"/>
    <dbReference type="OMA" id="NRADYAP"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13458" checksum="57CBF56AE4D9036A" modified="2013-03-06" version="1">MIEVKTFGELIKQARKEKKYSQRELADKLGIDFTYLSKLENDRGNPPKEDIIRQLAQYLTLDENKLIFLAGKIPSEDEELIKQHYKDMPLLFRRMRENPEFAAKIFRQAREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZQ4</accession>
    <name>K9YZQ4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218163.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0282"/>
    <dbReference type="EnsemblBacteria" id="AFZ52431">
        <property type="protein sequence ID" value="AFZ52431"/>
        <property type="gene ID" value="Cyan10605_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0282"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.292"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305200_0_0_3"/>
    <dbReference type="OMA" id="VYVILHI"/>
    <dbReference type="OrthoDB" id="175945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="437"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="460"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1046" mass="120812" checksum="7F94E9247908D4A0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F0</accession>
    <name>K9Z0F0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="13" type="ordered locus">Cyan10605_0021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0021"/>
    <dbReference type="EnsemblBacteria" id="AFZ52182">
        <property type="protein sequence ID" value="AFZ52182"/>
        <property type="gene ID" value="Cyan10605_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0021"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.22"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_3"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="12">
        <location>
            <begin position="64"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="644" mass="71412" checksum="C918AAE717B273B1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F1</accession>
    <name>K9Z0F1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ordered locus">Cyan10605_0507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218380.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0507"/>
    <dbReference type="EnsemblBacteria" id="AFZ52649">
        <property type="protein sequence ID" value="AFZ52649"/>
        <property type="gene ID" value="Cyan10605_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0507"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.537"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_3"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="437" mass="47253" checksum="E5382A6CC73BB015" modified="2013-03-06" version="1">MVVSREKTPTAQETFLQMAQAAGLRSRLLITLGLLILVRLGIYIPVPGIDRDAFAAAIQNLPFLGFLDIFTGGGLSTIGIFALGILPYINASIIMQLMTSAVPALEDLQKNEGEMGRRKIAQITRYVALGWAIIQSTGVTVGLLRPYALNDSPWFVVETVLAITAGSMFVMWISEVITERGLGNGASLLIFVNIVAVLPQTLANTIDYAQTGGRQAIAQVTILVLVFLVMIVGIVFVQEGTRRIPIISARRQVGRRLYRERTSYLPLRLNQGGVMPIIFASAVLVLPSSVSGFAENTAFSGVVNQVALALRPGSIWYVVVYSVLILFFSYFYASLVSNPEDIAQNLKKMGTSIPGIRPGKATVAYLEGVLNRLTLLGAIFLTVVATVPTFVERATGVTTFQGFGATSLLILVGVAIDTAKQVQTYVISQRYEGMVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F6</accession>
    <name>K9Z0F6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="5" type="synonym">rps8</name>
        <name evidence="7" type="ordered locus">Cyan10605_0512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218385.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0512"/>
    <dbReference type="EnsemblBacteria" id="AFZ52654">
        <property type="protein sequence ID" value="AFZ52654"/>
        <property type="gene ID" value="Cyan10605_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0512"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.542"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_3"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="14676" checksum="5A6BBE29D7FBB252" modified="2013-03-06" version="1">MPAHDTISDMLTRIRNACAVRHSTVAIPSTRMTRNIADVLKEEGFIGGYEEVGEGVKKNIVVSLKYKGRNRQPVIHNIRRVSTPGLRVYSKKKDLPRVLGGIGVAIISTSSGIMTDREARKQGIGGEILCYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q0</accession>
    <name>K9Z0Q0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ordered locus">Cyan10605_0590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218460.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0590"/>
    <dbReference type="EnsemblBacteria" id="AFZ52729">
        <property type="protein sequence ID" value="AFZ52729"/>
        <property type="gene ID" value="Cyan10605_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0590"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.622"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_3"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="12"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="287"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="41327" checksum="0BCCB1DB3B40AF0D" modified="2013-03-06" version="1">MTQSSKLLRTPLYSLSHECKAKFTDFAGWEMALQYSGLKKEHQAVRESVGMFDISHMGKFFLEGKQLREKFTYLVPTDLKNLEAGKAQYTVLLNHHGGIIDDIIFYYQGTNELEIESAILIVNAATKNKDWQWLTKNLTAKNVTLTDKSSELALIALQGKNGFKILNHLINEDLSQFPSFSHLYTTLYEEPVFIARTGYTGEDGFEIMTTPNVAQKLWYYFLDNGVIPCGLGARDTLRLEAAMCLYGQDMNEEITPIEAGLGWLINLDHDFIGKDVIAQQKQEGVKKKLVALVMEGKYIARHGYPILVNGEVIGEITSGTLSPTLEDAIALGYVSSNYSKIGQKLEIEIRGKLYPAKIVKKPFYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R0</accession>
    <name>K9Z0R0_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Virulence-associated E family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0600"/>
    <dbReference type="EnsemblBacteria" id="AFZ52739">
        <property type="protein sequence ID" value="AFZ52739"/>
        <property type="gene ID" value="Cyan10605_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0600"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.633"/>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323079_0_0_3"/>
    <dbReference type="OMA" id="CEITKEL"/>
    <dbReference type="OrthoDB" id="51615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="895" mass="104149" checksum="7E8F85C729E2233B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W0</accession>
    <name>K9Z0W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218567.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0700"/>
    <dbReference type="EnsemblBacteria" id="AFZ52836">
        <property type="protein sequence ID" value="AFZ52836"/>
        <property type="gene ID" value="Cyan10605_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0700"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.733"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_3"/>
    <dbReference type="OMA" id="QPLNVMR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="374"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="476"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="732"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="852" mass="97828" checksum="E1BF9B6E709135CB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z112</accession>
    <name>K9Z112_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218622.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0758"/>
    <dbReference type="EnsemblBacteria" id="AFZ52891">
        <property type="protein sequence ID" value="AFZ52891"/>
        <property type="gene ID" value="Cyan10605_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0758"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.796"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_0_1_3"/>
    <dbReference type="OMA" id="FARCTGD"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045039">
        <property type="entry name" value="NSI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43626">
        <property type="entry name" value="PTHR43626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="20212" checksum="67C57A46EC669E41" modified="2013-03-06" version="1">MVWLQKLFTKTDNDNILSDKTDERDWLNLDPQVFGRSKIFFSTNQSIDLYELEELCDSVGWARRPLRKVKKALDHSYLVASAWEVRGAKTSLIGFARATSDHAFNATIWDVVIHPRFQSKGLGKAFMKYVIRKLRKDDISNVTLFADAHVVEFYQRLGFIPDPEGIRGMFYYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F2</accession>
    <name>K9Z1F2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217905.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0012"/>
    <dbReference type="EnsemblBacteria" id="AFZ52173">
        <property type="protein sequence ID" value="AFZ52173"/>
        <property type="gene ID" value="Cyan10605_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0012"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.13"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_3"/>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="15"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="35999" checksum="C54FE3EF9D33E788" modified="2013-03-06" version="1">MKTRQLGKSDIYITPIIMGTWQAGKRMWAGIEDSESISAIRQAVESGITTIDTAEVYGEGHSERIVGEALKSVRDKVIYASKVFANHLKYDQVISACHNSLKNLQTDYIDLYQIHWPSGSWNSEIVPIEETMRALNDLKREGKIRAIGVSNFSQQQLASARECGQIDSIQPPYSLFWRIVEKEIQPYCVENNISILAYSSLAQGILTGKFGDNPTFAEGDHRKNNRLFQPPHWERVKQALSQLQPFADKYNCTLAQIAIAWLIQQPQTNAIVGARNAQQAKENAQAGEIELTIEDIKQISNIGTNVTKDLDDNPVMWNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G2</accession>
    <name>K9Z1G2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218303.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0428"/>
    <dbReference type="EnsemblBacteria" id="AFZ52572">
        <property type="protein sequence ID" value="AFZ52572"/>
        <property type="gene ID" value="Cyan10605_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0428"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127610_2_0_3"/>
    <dbReference type="OMA" id="RWVDLKP"/>
    <dbReference type="OrthoDB" id="2012286at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024700">
        <property type="entry name" value="UCP020217"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020217">
        <property type="entry name" value="UCP020217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="3">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="14294" checksum="AA3B5F791FA38F28" modified="2013-03-06" version="1">MTTEDIYIKYWQNKIIQQKQKNLEEKKKAREVLNKIKQVLIEEFSVNKIILFGSLLTDKFDEESDIDLAVEGIKKSDFFHAFAVVNDLGIKYMVDLKPLEDLEPYFLEKVLKKGECIYEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K1</accession>
    <name>K9Z1K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218817.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53086">
        <property type="protein sequence ID" value="AFZ53086"/>
        <property type="gene ID" value="Cyan10605_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0956"/>
    <dbReference type="eggNOG" id="ENOG5032SH5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152501_0_0_3"/>
    <dbReference type="OMA" id="FIAKIYK"/>
    <dbReference type="OrthoDB" id="1622152at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041375">
        <property type="entry name" value="VapC45_PIN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18478">
        <property type="entry name" value="PIN_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_10" evidence="1">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16609" checksum="73C3E824B341C048" modified="2013-03-06" version="1">MSKHHKFKHTYFIDRTLGKSVAKALQNLGVKVELHKNHFPSNSPDIEWLPIVSKKGWVVLTKDTNIGRNILEIKAMAYFKAKVFTLVSADLNNAKMIEIFEQTIEKIDNFATTNTAPFIAKIYKNSTIKLWKNHTKLNKNLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L6</accession>
    <name>K9Z1L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217975.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0084"/>
    <dbReference type="EnsemblBacteria" id="AFZ52243">
        <property type="protein sequence ID" value="AFZ52243"/>
        <property type="gene ID" value="Cyan10605_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0084"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.86"/>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337334_0_0_3"/>
    <dbReference type="OMA" id="PRFHENW"/>
    <dbReference type="OrthoDB" id="1691668at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="843" mass="91911" checksum="F282B5880AFDB9D4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N0</accession>
    <name>K9Z1N0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Photosystem I iron-sulfur center</fullName>
            <ecNumber evidence="3 17">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">9 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">PSI-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">Photosystem I subunit VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">PsaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">psaC</name>
        <name evidence="19" type="ordered locus">Cyan10605_0338</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-81</scope>
    </reference>
    <comment type="function">
        <text evidence="2 17">Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 2 [4Fe-4S] clusters. Cluster 2 is most probably the spectroscopically characterized electron acceptor FA and cluster 1 is most probably FB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cellular thylakoid membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="3 17"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012307203.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="3/C/c=2-81"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z1N0"/>
    <dbReference type="STRING" id="755178.Cyan10605_0338"/>
    <dbReference type="EnsemblBacteria" id="AFZ52485">
        <property type="protein sequence ID" value="AFZ52485"/>
        <property type="gene ID" value="Cyan10605_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0338"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.353"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_8_0_3"/>
    <dbReference type="OMA" id="GHMSHAV"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01303">
        <property type="entry name" value="PSI_PsaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017491">
        <property type="entry name" value="PSI_PsaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03048">
        <property type="entry name" value="PS_I_psaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 17" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ52485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="81" mass="8814" checksum="57B7D4A3371A4AFB" modified="2013-03-06" version="1">MSHSVKIYDTCIGCTQCVRACPLDVLEMVPWDGCKAGQIASSPRTEDCVGCKRCETACPTDFLSIRVYLGAETTRSMGLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U4</accession>
    <name>K9Z1U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218080.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0192"/>
    <dbReference type="EnsemblBacteria" id="AFZ52348">
        <property type="protein sequence ID" value="AFZ52348"/>
        <property type="gene ID" value="Cyan10605_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0192"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.202"/>
    <dbReference type="eggNOG" id="ENOG50314QQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128733_0_0_3"/>
    <dbReference type="OMA" id="INISAQW"/>
    <dbReference type="OrthoDB" id="1565194at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="175" mass="19631" checksum="DB544FDAAB26A9A1" modified="2013-03-06" version="1">MNSNLIADKNISFEDAIALTERFIEQISQLSEAEKEKVISSLVATENGARGLFVTYLTSDNSVVDNPSPGIINGLKTSPQIVSELLVKNVAMSTGMRLTHTRNNNPDMAESSFKVTQRSLNLINELSLPETKEKIILLINTIKEKEGVYQEFLSRWGYDEEQKKQILDVLTKIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V4</accession>
    <name>K9Z1V4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218418.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0546"/>
    <dbReference type="EnsemblBacteria" id="AFZ52687">
        <property type="protein sequence ID" value="AFZ52687"/>
        <property type="gene ID" value="Cyan10605_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0546"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.577"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_3"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="342"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="460" mass="49999" checksum="65DE627006F1A1B3" modified="2013-03-06" version="1">MRVCVIGTGYVGLVTGVCLAHIGHDVICVDNNEEKVKLMKQGQSPIYEPGLSELMLSCMKHKKLNFTTDLGAGVNHGEILFIAVGTPALPTGESDTRYVEAVARGIGNYLNGGYKVIVNKSTVPIGSGDWVRMIVLEGFKEKHTATVGEGFTMTENSMPEFDVVSNPEFLREGTAVYDTFNPDRIVLGSSNEKAIALMKELYQPLVDRTFSDHPDLPPVPIVVTDLSSAEMIKYAANAFLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGPKFLQAGIGWGGSCFPKDVSALIHTAHDYGYETELLNAAVNVNKRQKSIVIEKLQQELKILKGKVIGLLGLTFKPDTDDMRDAPALNIIQELNRLGAKVKAYDPIVSQTGLSHGLSGVVIESSTEMLADGCDALVLVTDWQEFLKLDLEKISKLMKNHLIIDGRNFLDKTAIEKTGFHYVGIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V8</accession>
    <name>K9Z1V8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureC</name>
        <name evidence="13" type="ordered locus">Cyan10605_0551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218423.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z1V8"/>
    <dbReference type="STRING" id="755178.Cyan10605_0551"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="AFZ52692">
        <property type="protein sequence ID" value="AFZ52692"/>
        <property type="gene ID" value="Cyan10605_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0551"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.581"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_3"/>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="OrthoDB" id="157757at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="131"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="579" mass="62864" checksum="3505B76844111D5C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z273</accession>
    <name>K9Z273_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218401.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0528"/>
    <dbReference type="EnsemblBacteria" id="AFZ52670">
        <property type="protein sequence ID" value="AFZ52670"/>
        <property type="gene ID" value="Cyan10605_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0528"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_3"/>
    <dbReference type="OMA" id="FPARYNI"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="27204" checksum="C3E56045D1102EDE" modified="2013-03-06" version="1" precursor="true">MCGRFVLSVSSVSIKKTFSLGSCPIFSPSYNIAPTQKILAILGEEESSLNPLSENNKWKSCFLHWGLIPSWAKNSKNSSNLINARLETLGVKPSFKQAFSQRRCLIPANGFYEWNREVYGKNPLLFYKTNKEVFAFAGLWEKWQSPTGEIIESATIINTQARGIMAEIHPRMPIILKKCAYQIWLDKSIQDPNLLSEILQSNLEDNLHFYPINEAVNSVKNNYPELLEPEKVSKQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z280</accession>
    <name>K9Z280_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218568.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0701"/>
    <dbReference type="EnsemblBacteria" id="AFZ52837">
        <property type="protein sequence ID" value="AFZ52837"/>
        <property type="gene ID" value="Cyan10605_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0701"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.734"/>
    <dbReference type="eggNOG" id="ENOG5032T20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093454_1_0_3"/>
    <dbReference type="OMA" id="FAQCVVG"/>
    <dbReference type="OrthoDB" id="1906263at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938556" evidence="1">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="19327" checksum="AE2269A15B5E5F41" modified="2013-03-06" version="1" precursor="true">MNNLLKLATITISGAFSLANFAFFSNSVKAENQFDVCLRELTASGVTVEDAQTGCADALVPRELSSCVTNISQSTSISAKDALTSCYQVRRPVDLGNCVVSINNTVLTASNKNTQAKVEGDNSQSPLMMALSTCQASLLPTRQSECVIALSRTPQASNPVKAMETCLSAEDFPRDLFPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C6</accession>
    <name>K9Z2C6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PsbN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">psbN</name>
        <name evidence="6" type="ordered locus">Cyan10605_0569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in photosystem I and II biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PsbN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Originally thought to be a component of PSII; based on experiments in Synechocystis, N.tabacum and barley, and its absence from PSII in T.elongatus and T.vulcanus, this is probably not true.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218441.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0569"/>
    <dbReference type="EnsemblBacteria" id="AFZ52710">
        <property type="protein sequence ID" value="AFZ52710"/>
        <property type="gene ID" value="Cyan10605_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0569"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.600"/>
    <dbReference type="eggNOG" id="ENOG50339MH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205504_0_0_3"/>
    <dbReference type="OrthoDB" id="2042219at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00293">
        <property type="entry name" value="PSII_PsbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003398">
        <property type="entry name" value="PSII_PsbN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35326">
        <property type="entry name" value="PTHR35326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02468">
        <property type="entry name" value="PsbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="43" mass="4424" checksum="D13986688D3C808A" modified="2013-03-06" version="1" precursor="true">MDTATLIGFGIAAVLIAITGVSIYTAFGPPSAELGDPFEDHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F4</accession>
    <name>K9Z2F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218471.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0601"/>
    <dbReference type="EnsemblBacteria" id="AFZ52740">
        <property type="protein sequence ID" value="AFZ52740"/>
        <property type="gene ID" value="Cyan10605_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0601"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.634"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125297_0_0_3"/>
    <dbReference type="OMA" id="HQNLIEM"/>
    <dbReference type="OrthoDB" id="1342011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044995">
        <property type="entry name" value="TMT/HOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="entry name" value="PTHR32183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="18524" checksum="1116586D17D57576" modified="2013-03-06" version="1">MSQSLEIPKLDTLAQELAAIQQTGSKKIALLGSRHVPITHQHLIEMMSYALVLEGNRIITSGAAGTNSAAIKGAMRADPNLLTVILPQSLARQPKESQEQLKQVIHLVENPDYDNLSLGEASAICNRDIISRCQQLICFAFHDSHTLIQTCKEADEQRKVVTRFYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G2</accession>
    <name>K9Z2G2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpxC</name>
        <name evidence="13" type="ordered locus">Cyan10605_0789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218653.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0789"/>
    <dbReference type="EnsemblBacteria" id="AFZ52922">
        <property type="protein sequence ID" value="AFZ52922"/>
        <property type="gene ID" value="Cyan10605_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0789"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.830"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_0_0_3"/>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="29812" checksum="D5B472A090BF7994" modified="2013-03-06" version="1">MFKPFTLSGVGLHSGDVTTVKISPANREEGRFFVRVDLPNQPVIKASIESVSPTMLSTELTNGDVKIRTVEHLLAALWGCGIEGARIEIDGSEVPLLDGSAQEWVKHIELKDDDKISYSSEGEINEAIWVRKDDGFCVAFPSPEMKFSCGVDYPYPVLQNLWYSWYPQRETFQDAIAPARTFGFADQIEMLKSQGLIKGGSLENALVCDYNGWLNPPLRFENEAVRHKLLDFIGDLSLLGNIPRGHYLAYKASHQLHTELAKKIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T5</accession>
    <name>K9Z2T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multisubunit sodium/proton antiporter, MrpD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219250.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1409"/>
    <dbReference type="EnsemblBacteria" id="AFZ53521">
        <property type="protein sequence ID" value="AFZ53521"/>
        <property type="gene ID" value="Cyan10605_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1409"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1489"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_6_3"/>
    <dbReference type="OMA" id="NELTIGW"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="116"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="52993" checksum="471D0995A72B99AC" modified="2013-03-06" version="1">MNNTITLIWLALPFVAGFLVYLLPKYSSYLSLGGLLISISYPVWILTSEVDFTLRLLDNFGVTLYVDQLSGYFILTNCLVTIGVLIYCLSEERKAFFYTQLMILYGSVNACFIGYDFISFYVAIEVISIAAFLLMVYPRSDKSIWIGLRYLFVSNTAMLFYLIGAILIYKANNSFSFDGLINSPPEAIALILLGLLVKGGVFVSGLWLPLTHASVETPLSGLLSGIVVKAGIFPFLRLASISDEVDFVIRIVAIATAYLGVIQAIFENDTKRLLALSTVSQLGFIIASPMIAGFYALTHGLAKCTLFLTVGNLPSRDIKQLNQEGVNFYLWFVLFLGSSSIIGIPLLAGFSAKVMVMKNILSWQNIPFNLAVIGTAIALSKLIFLPTANTSISETAVKRGYWLGVSILMGGLIATNLIYPQTYTVVNISKALITFAIGALIYLFILKKITLKLPRTLEKFDNLIGIMSLTVIGLFWMVLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X6</accession>
    <name>K9Z2X6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1397"/>
    <dbReference type="EnsemblBacteria" id="AFZ53509">
        <property type="protein sequence ID" value="AFZ53509"/>
        <property type="gene ID" value="Cyan10605_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1397"/>
    <dbReference type="HOGENOM" id="CLU_191193_1_0_3"/>
    <dbReference type="OMA" id="MERPKWV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="57" mass="6315" checksum="A8B9EEAB0ED71AFC" modified="2013-03-06" version="1">MERKKIVAIVTGIVSVLLGVVYLILVELLDSRGAMIPAPINDVSLLLSWLFSSHFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z315</accession>
    <name>K9Z315_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="6" type="ordered locus">Cyan10605_0604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218474.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0604"/>
    <dbReference type="EnsemblBacteria" id="AFZ52743">
        <property type="protein sequence ID" value="AFZ52743"/>
        <property type="gene ID" value="Cyan10605_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0604"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.637"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_3"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="248"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="53411" checksum="0718E57A860B4BB7" modified="2013-03-06" version="1">MGIIIAGERSGVGKTTITLALLSWLTRLGKSIQSFKVGPDYIDPMFHTAITGNGCRNLDPILTSPDYVKWCFDYYTQDKDIAIVEGVMGLFDGVPNSQNAHYGSTAYIAKLLNLSVILTLDCSKISSSISAIASGYINFDREVKIVGVILNKVASEKHLSLLRIGLEKLNIPIMGVWFKHQKIELPSRHLGLIPTEEVTQHQKIFQQLGELAKQNINWQLLNKYLYSEKSMKKVDYFLGNNYHKYPLKIAIAKDKSFNFYYQDNLDILKYLGIELIEVSPLEDKNLPSDIDGIYLGGGFPEIFALQLSENKSFQMNIKKKIENGIPTYAECGGMMYLSAGIEDFRGDKWEMVGVLPHFTVMSNKLTIGYRQVKTLITNDFININQTLMGHEFHRAVDSFQPIPYQIDKLSAPMLEFQDYYSQKIISYQGWQRYNVFASYLHLHFGKLIPQLETFLQGCLSWRNRAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z329</accession>
    <name>K9Z329_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218858.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0998"/>
    <dbReference type="EnsemblBacteria" id="AFZ53127">
        <property type="protein sequence ID" value="AFZ53127"/>
        <property type="gene ID" value="Cyan10605_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0998"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1055"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_3"/>
    <dbReference type="OMA" id="FADCVLG"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="34911" checksum="F94FDF4CC8A24B44" modified="2013-03-06" version="1">MKVLITGGAGYIGSVLTPTLLKRGYEVTVVDNFMFHQNSLADCCQYETFNVVRGDCRDESLMKDLVKDADVIIPLAALVGAPLCNRDKIATETTNRDAIQMLCRLASKEQRFLVPITNSGYGVGEKGKFCTEESPLRPISTYGVTKVEAEKAILERENSISFRLATVFGMSPRMRIDLLVNDFVYRAVTDRTVVVFEGHFKRNYIHIRDVVNVFLHGLDNFEAMKGKPYNVGLEDANLSKLELCAEIQKQIPNFVYMEAPIGEDPDKRDYIVSNARILSTGFEPQWPLSRGIKELIKGYTMIRNTIYSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z379</accession>
    <name>K9Z379_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="13" type="ordered locus">Cyan10605_1498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219338.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1498"/>
    <dbReference type="EnsemblBacteria" id="AFZ53609">
        <property type="protein sequence ID" value="AFZ53609"/>
        <property type="gene ID" value="Cyan10605_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1498"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1590"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_3"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="8"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="881" mass="98030" checksum="38B44E0700CCD479" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B9</accession>
    <name>K9Z3B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0740"/>
    <dbReference type="EnsemblBacteria" id="AFZ52873">
        <property type="protein sequence ID" value="AFZ52873"/>
        <property type="gene ID" value="Cyan10605_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0740"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.777"/>
    <dbReference type="eggNOG" id="ENOG503342B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175353_0_0_3"/>
    <dbReference type="OMA" id="LIYQHWQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="10245" checksum="B84B403E45A89131" modified="2013-03-06" version="1">MMLTVNLDHESEKYLIEILSEEKITSQELVKKLLRNHWISLKKPPTVLEKMGGYPEHLLDGEEDLSDRDIRKQKIAQYLHQKHEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G4</accession>
    <name>K9Z3G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219001.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1150"/>
    <dbReference type="EnsemblBacteria" id="AFZ53272">
        <property type="protein sequence ID" value="AFZ53272"/>
        <property type="gene ID" value="Cyan10605_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1150"/>
    <dbReference type="eggNOG" id="ENOG5033D1D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185923_0_0_3"/>
    <dbReference type="OMA" id="DKYTKHY"/>
    <dbReference type="OrthoDB" id="2020399at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9437" checksum="2E68AF99908985B0" modified="2013-03-06" version="1">MNNKIRYTDEDLEFGEIVEDFLPPPEKLTLKGIKIQIPVELTEKNLSFLKQEANRNNISYQNLIELIINEYIEQHGQNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H0</accession>
    <name>K9Z3H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase M10A and M12B matrixin and adamalysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219011.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1160"/>
    <dbReference type="EnsemblBacteria" id="AFZ53282">
        <property type="protein sequence ID" value="AFZ53282"/>
        <property type="gene ID" value="Cyan10605_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1160"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1227"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079047_0_0_3"/>
    <dbReference type="OMA" id="HALGIWG"/>
    <dbReference type="OrthoDB" id="1886182at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ZnMc" evidence="6">
        <location>
            <begin position="72"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="262" mass="29925" checksum="D1B6118A09AFB7DC" modified="2013-03-06" version="1" precursor="true">MLSPTIRFLTKVIFPLFLITFIGFIFAIPSISQEAESSLPPFKTYPLPQTLQNWHSDNQENYFSQLDTHPAGALIWTDFPVKVYIQSPAEDDLSPSALQSFQQWQKAVKDAIAPWQEYIEIRQIDNADIADIVITRQPPAIKAEINPETGLYDLPRNRAATTSVRFYLTEDNPPLLKHKMAIAVNPNQIFEYLVSNISHEMGHALGIWGHSDNPQDIMYYAHTREIPQISPRDINTLKKVYQQPTRLGNYLTSVRFKNIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K0</accession>
    <name>K9Z3K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218896.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53165">
        <property type="protein sequence ID" value="AFZ53165"/>
        <property type="gene ID" value="Cyan10605_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1039"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1100"/>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13297" checksum="68B004516341C768" modified="2013-03-06" version="1">MSKEAVEEFFAKIPEDDNLQQKLVSILQADIDHRQETAKLAQEYGFDITAEELSEEVKKRQEEFAQRQESGELSEEELESVAGGLSFPGTFSFPSPIPGTFPFPTPRPGPIPFPKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L7</accession>
    <name>K9Z3L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219446.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1612"/>
    <dbReference type="EnsemblBacteria" id="AFZ53719">
        <property type="protein sequence ID" value="AFZ53719"/>
        <property type="gene ID" value="Cyan10605_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1612"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1713"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796569_0_0_3"/>
    <dbReference type="OMA" id="KVVWLVH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="PTHR45918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="39538" checksum="5D361DBA021C1188" modified="2013-03-06" version="1" precursor="true">MKIIVLSVSAPFIMGGAEIHADSLLKALRKFGYEAELVTIPFKSYPNQRILDTMLMFRLLDITESCGQKIDLVIPLKFPAYLTPHPNKVLWLLHQHRDAYDLWGKPVCGLAQNPDGQQIRDTIINADNRAFAECKKIYANSQNVANRLKYYNNVDSIPLYHPPQNAEKFYSKSAQRYFFFPSRLTKIKRQELILEAMAKTHYPVKVVFAGAADDGKYDRDLQILAEKLGIEDRAIFVGRISEEEKLTYYSECLGVIYPPFDEDYGYITLEGMLSSKPIISCLDSGGPLEFLVNQETGIIVDSTPDAIASAMDQLWDNPKQSMIMGKNARSHYESMNISWMNVIEKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S1</accession>
    <name>K9Z3S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218764.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0903"/>
    <dbReference type="EnsemblBacteria" id="AFZ53033">
        <property type="protein sequence ID" value="AFZ53033"/>
        <property type="gene ID" value="Cyan10605_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0903"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.948"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054763_0_0_3"/>
    <dbReference type="OMA" id="MEPYRGF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022623">
        <property type="entry name" value="Glyco_trans_4_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12000">
        <property type="entry name" value="Glyco_trans_4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4_3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="421" mass="48583" checksum="AF927201EC938BFC" modified="2013-03-06" version="1">MSERRKTILFIHPNFPAQFRHLGLLLGKNPLYDVFFLTKKKEGAIEGITKIIYQPSREAKPETHHYVRPIENAVLQGQAVYRALINLKQKGFYPDIIYGHSGWGSTLFVKDIFPRALFLAYFEWFYHAIGTDADFDPNEPLTADDQARIRVKNTPILIDLYSCDRGLSPTQWQKQQFPREYHNKITVLHDGVDTDYFQPNADTKLVIPSLNLDLSDKAEIITYVARGMEPYRGFPQLIETIYILQKRRPQSHFVIVGQNRVAYGKQLPEGQNYQDLMLAKFPLDLTKVSFTGLLPHSEYLKVLQASSAHIYLTRPFVLSWSMLEAMATGCVVIASDTQPVKEIIVDNYNGFLVPFFEPEKIADKVEYALFNQDLMAKIRKKARQTIVENYKLSDLIQKHIHWIETGKLTPLTTKKKKIRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V2</accession>
    <name>K9Z3V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218974.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1123"/>
    <dbReference type="EnsemblBacteria" id="AFZ53245">
        <property type="protein sequence ID" value="AFZ53245"/>
        <property type="gene ID" value="Cyan10605_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1123"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1187"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040163_0_0_3"/>
    <dbReference type="OMA" id="YQWIAAA"/>
    <dbReference type="OrthoDB" id="1233154at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="488" mass="55341" checksum="9236563C6076568C" modified="2013-03-06" version="1">MNILIKKPILVAGISLSFLLWIGQKLTNYWDEIGNVSIFSLICLGGLSYFLQQIGRKKSVNQLNLLDITINDLTAKIASIKNQIEALNCELNEIEEKDNQDAKINIKINNFQQQLNTIQQSFPRNNLNIAILNLSQNTNSFALSQDIEKKVKTLVNFHGINDVLETFNNANNLTNLVLEYDLLLLIISEDLTQSQKEIISYCKNQQQNLIIVFDDINYTLQEEKKLILNSLKKALDSVIEEKYIIPISSKKQTIKVRRYEENSTYKEWEETFNADHEKLIETLLILTEKELGKLTLSTTYRQAINVEKQIREELNAIRKNKSLKVVEKYQMVAATATFANPVSSLDLLATAAINAQMIVDLSKIYQHPLSLNQAQQISLTLAKVMLKLGIVEISSQTISAILKTNMITFVAGGLIQGISAAYLTRVCALSLIEYYEVADFTVNDNINISKLKEKIQLIFEQNKENNFLNQFVKKTSLLLTSVQPKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y8</accession>
    <name>K9Z3Y8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219576.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1747"/>
    <dbReference type="EnsemblBacteria" id="AFZ53849">
        <property type="protein sequence ID" value="AFZ53849"/>
        <property type="gene ID" value="Cyan10605_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1747"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1854"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="WQGEVWK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="431"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="573"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="833" mass="95930" checksum="902E12150F9D581B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z5</accession>
    <name>K9Z3Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219648.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1819"/>
    <dbReference type="EnsemblBacteria" id="AFZ53921">
        <property type="protein sequence ID" value="AFZ53921"/>
        <property type="gene ID" value="Cyan10605_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1819"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1930"/>
    <dbReference type="eggNOG" id="ENOG50314NH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138207_0_0_3"/>
    <dbReference type="OMA" id="FLEVFCN"/>
    <dbReference type="OrthoDB" id="1808095at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12700" checksum="C29846EDADC2DB85" modified="2013-03-06" version="1" precursor="true">MSQLTLNLIQGSVSFNFTSSAAENLQTEINHLMQSLKEIALQNKTGGKPTPKTAMEYQYTGDVFLELFCNPNIYPSPFSAKVLVTLRSPQIRLTSEAELTRLVEDLEQYLQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z420</accession>
    <name>K9Z420_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Photosystem II 12 kDa extrinsic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PS II complex 12 kDa extrinsic protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">PSII-U</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">psbU</name>
        <name evidence="4" type="ordered locus">Cyan10605_1782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">With PsbO,P,Q and V forms the oxygen-evolving complex of photosystem II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cellular thylakoid membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Lumenal side</orientation>
        </subcellularLocation>
        <text evidence="3">Associated with photosystem II at the Lumenal side of the thylakoid membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PsbU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219611.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1782"/>
    <dbReference type="EnsemblBacteria" id="AFZ53884">
        <property type="protein sequence ID" value="AFZ53884"/>
        <property type="gene ID" value="Cyan10605_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1782"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1891"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141240_1_0_3"/>
    <dbReference type="OMA" id="LLGCWGW"/>
    <dbReference type="OrthoDB" id="1626529at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042549">
        <property type="term" value="P:photosystem II stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00589">
        <property type="entry name" value="PSII_PsbU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010527">
        <property type="entry name" value="PSII_PsbU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06514">
        <property type="entry name" value="PsbU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="3" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009016573" description="Photosystem II 12 kDa extrinsic protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16067" checksum="7F2BA1F97C139332" modified="2013-03-06" version="1" precursor="true">MKLWRNFITFIAVTFFVCAGVFHAPVQALDFNTVLQASPRMVAAETNRRNAADDLLTTEFGQKIDINNSDIRDFRELKGFYPKLASIIIQNAPYEQVEDVLNIPGLSESQKERLQANLDNFTANPQSSVFNEGDERYNAGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z439</accession>
    <name>K9Z439_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1017"/>
    <dbReference type="EnsemblBacteria" id="AFZ53143">
        <property type="protein sequence ID" value="AFZ53143"/>
        <property type="gene ID" value="Cyan10605_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1017"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1077"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049858_0_0_3"/>
    <dbReference type="OMA" id="LQIWGTW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="143"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="449" mass="52047" checksum="FD868463F7F67CF3" modified="2013-03-06" version="1">MTKKINRDHAQKKHHPLSENDAIVSHLSELLTPSIFAQQSLFRDLGMRNRVLNLSLMTAAILTLLWRNVPSVNELTRILNREGFLWVDPTKVSQKALSDRFLTFPSILFEQIFKQLLPKFKERWQKRTNRPLPDSVCFSLTKFKQIWIVDGSTLEALFRKLDSLKDIPTGKLAGKMAVVMDLATRLPVEIWVEENPSISDVKFEENILNLVKSQTLLLLDRGFYHFLFWQELITRNIDFITRIKKGASIEILKRFTNSHDLRDSLINIGDGRKKTPIVTLRLVEIRSKNKWHSYLTSVTSPEILPPHVVVNLYGKRWRIEEAFNTVKRLLGLSYLWTGSINGIKLQIWGTWLFYGVLIDLGDAVAEELSLPFDSISIEMIYRGLYHFIVANNKGKAKEVVKYFSAPENRDLGIIKRKRKPRQKLIIAPFPELGKNQKNFFFENSLTPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A3</accession>
    <name>K9Z4A3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyanobacterial porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218919.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1064"/>
    <dbReference type="EnsemblBacteria" id="AFZ53188">
        <property type="protein sequence ID" value="AFZ53188"/>
        <property type="gene ID" value="Cyan10605_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1064"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1126"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018575_1_0_3"/>
    <dbReference type="OMA" id="HFYADTF"/>
    <dbReference type="OrthoDB" id="1383921at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="528" mass="57506" checksum="C8C09C740D0E35B1" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P4</accession>
    <name>K9Z4P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219414.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1578"/>
    <dbReference type="EnsemblBacteria" id="AFZ53687">
        <property type="protein sequence ID" value="AFZ53687"/>
        <property type="gene ID" value="Cyan10605_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1578"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_0_1_3"/>
    <dbReference type="OMA" id="DCATTTN"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026358">
        <property type="entry name" value="Orph_peri_GRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04262">
        <property type="entry name" value="orph_peri_GRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938589" evidence="2">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="33073" checksum="C8139D41793D16D1" modified="2013-03-06" version="1" precursor="true">MFRKILMTFLMTLILSVGIKPAFAETVVERISRTGNLVVGTPFGLVPYAYNNSNEELDGYSIDVVKQIQKQLELRFGKQIQLSFVEVNNISDAVSKILTGEIDIACNTVFTWQRDQFVDYTLGYTQSDIRLLIPKGKTIDNFSGKKIGIPPLTFVYSAISLNHPDATLVEVKTTEEGLQALKEGKIDALAGDAIILDGESQQAQMTADFELFPKGVQGYGNYGVSCIVPENNSTFLNVANYAIARMMEGYLVGNEEMTTMVNRWLGEDGVVTIVTKEHLKTFFCNTINNYEQIPFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y7</accession>
    <name>K9Z4Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219529.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1699"/>
    <dbReference type="EnsemblBacteria" id="AFZ53802">
        <property type="protein sequence ID" value="AFZ53802"/>
        <property type="gene ID" value="Cyan10605_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1699"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1805"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="28700" checksum="49FCD081FB059CBA" modified="2013-03-06" version="1">MLCLDLPPIGANEKASVNYDILVVEDEQLIRNMIALNLADEGYNVIQAENGREALNVLERIGEENSKEKIDLIILDLMLPEVNGLDICRLLRYRGNNIPILILSAKAAETDRVLGLEIGADDYVTKPFSMKELIARCRALLRRNNINNNISSAIRQFKDITLYTTECRVTVRGEEVSLSPKEFRLLELFMTYPKRVWDREQLIENIWGADFLGDTKTVDVHIRWLREKLELDPSNPEYIVTVRGFGYRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z549</accession>
    <name>K9Z549_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purU</name>
        <name evidence="5" type="ordered locus">Cyan10605_2178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219989.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2178"/>
    <dbReference type="EnsemblBacteria" id="AFZ54264">
        <property type="protein sequence ID" value="AFZ54264"/>
        <property type="gene ID" value="Cyan10605_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2178"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2314"/>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_3"/>
    <dbReference type="OMA" id="HADHHTD"/>
    <dbReference type="OrthoDB" id="979667at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="291" mass="33032" checksum="3564200C4CC1791B" modified="2013-03-06" version="1">MAVDTATLLVSCPDQQGLVAKIANFIYANGGNIIHADHHTDLEAGLFLSRIEWQLQGFNLPRHLINEAFGELAQRHFVTASPLQAKWKLHFSDTVPKVAIWVSKQDHCLYDLLWRIKSKELKAEVGLIISNHPDLDPIAQQFNIEYHHLPITKENKKEQELKQLELLKNAEIDLVILAKYMQVLSSDFIKEFPAVINIHHSFLPAFIGAKPYHQAYSRGVKIIGATAHYVTQDLDAGPIIEQDVVRISHRDTVQDLIRKGKDLEKIVLARGVRLHLQNRVLVYGNRTVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z598</accession>
    <name>K9Z598_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMP/dCMP deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220080.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2271"/>
    <dbReference type="EnsemblBacteria" id="AFZ54356">
        <property type="protein sequence ID" value="AFZ54356"/>
        <property type="gene ID" value="Cyan10605_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2271"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2412"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_1_3"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="19637" checksum="05C55DEDECAF6025" modified="2013-03-06" version="1">MSTLEREIHRPTWDEYFMLMAKLASTRSTCLAFPVGAVIVKDRQVLATGYNGSPSGSAHCTAQGYCYEGLSSCDASKTLPSRAVHAEANAIAQAARHGIATQGATIYVTLEPCIACLKLIISAGIREVFYETNFNSGNKLLVRDAFVADNLVTLKQMNVREAIASNASRFLLEPVSLLDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B2</accession>
    <name>K9Z5B2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220095.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2287"/>
    <dbReference type="EnsemblBacteria" id="AFZ54371">
        <property type="protein sequence ID" value="AFZ54371"/>
        <property type="gene ID" value="Cyan10605_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2287"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2429"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_1_0_3"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="OrthoDB" id="1384440at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="RNR_small"/>
    </dbReference>
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        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        <ligand>
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        </ligand>
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            <position position="229"/>
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        <location>
            <position position="232"/>
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        <ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="41761" checksum="38F56DF16705E9FE" modified="2013-03-06" version="1">MVAIFPENKHRMPLTPIFNPQGDDRIENRTIWFGNTTNLMQLNDVRYSWAIGLYQQMRENFWIPQKLDITQDVTDYWNLTNDERRAFEGILSYLTFLDSVQTCNIPHLKSSITAPEISLCMAEQISQEGMHNHAYQYMIETIIPSEKRDKVYDFWRTDKVLAGRCEFIARMYQKYIDNPTEENYFIALLADYLLESLYFYNGFIYFYNLAARMLMPGSADIFKMINRDELSHVRLYQRLIPEAMRSFPHSLDQIYEMFDTAVQHECRWTNHIVGDNILGITQSSTERYTKYLANIRLRAIGLDPLYTDPEYSKSPYTHLEKFSDTKKDGNTKANFFESSVTSYVMSSGVAGWEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C0</accession>
    <name>K9Z5C0_CYAAP</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ordered locus">Cyan10605_2254</name>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7787" checksum="F64F4DCFE02A7164" modified="2013-03-06" version="1" precursor="true">MKIRFFSDKLSVYLFSILVVNILISPLVYASTNQVFSRGQSYALGLLGLVTMSLFIYLFVVIFQPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_1877</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="38431" checksum="69C09CF74C988025" modified="2013-03-06" version="1" precursor="true">MNVYKSINHNYVFSRIILSTLLGSTIFSFGNLNVEAKNSLTVSDENQEQIDYLSKNLISLENTNNSIQYRKGGSNSDIPYIITPRYTLISDNTPTLHWNEVEGASSYLVKIQGGDINWQQEVKDTTVVYSGAEMLKSGIDYFVSVEADTGVSSLDDSGAKLGFRLITSEQSNSLQDAIAPIQTSNLSQEEKGIKLAEKYHQLNLNADAIAILEQLKAEGSKSAQVYRLLGDTYAKTGLNLLAEENYLTAIELESANNNLESVTEIQASLVGVKIMLGKLEEAEELNQQAQAGYSKLGNVDKGQELNRTLTALTQGNSENPIRTRGSSQQTNSAQNQIDQVVTPNFGNDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G2</accession>
    <name>K9Z5G2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220150.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54426">
        <property type="protein sequence ID" value="AFZ54426"/>
        <property type="gene ID" value="Cyan10605_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2342"/>
    <dbReference type="HOGENOM" id="CLU_202531_3_0_3"/>
    <dbReference type="OrthoDB" id="2031047at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="45" mass="5282" checksum="2B803310B9D8CAB7" modified="2013-03-06" version="1">MAKVQLSVRVEESEMKLLIKYSKKLGRTKTDVVREFIRSLKSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H9</accession>
    <name>K9Z5H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1899"/>
    <dbReference type="EnsemblBacteria" id="AFZ53997">
        <property type="protein sequence ID" value="AFZ53997"/>
        <property type="gene ID" value="Cyan10605_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1899"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2015"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064263_0_0_3"/>
    <dbReference type="OMA" id="EWDTDVP"/>
    <dbReference type="OrthoDB" id="1602134at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="31694" checksum="2ADB096943F193B3" modified="2013-03-06" version="1">MGFGLNARSAGLNLCHENAEEFAMTMPSVDFVQVHPEHFLQDLGGNYVYAFEKLKENYPLTFHGFGLSIGSIAPLPENYLKLVKRLLAENEGSFFSEHFSWSSVSHHHFHDLIPFPFTQEVLDYFCERVEQVQEYLGSEILLENISSYMRFSISEMDEIAFMNEVFKRTGAKMLLDLNNLWANAQNFEEDALERMMAIKPEYVQSYHLAGCTAWGDNNYIDYHGEAVRDEVWQLYQKAMEVFGAKPTLIEWENNIPPISRTVEEVHKAKAILTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J4</accession>
    <name>K9Z5J4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54456">
        <property type="protein sequence ID" value="AFZ54456"/>
        <property type="gene ID" value="Cyan10605_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2373"/>
    <dbReference type="HOGENOM" id="CLU_2989071_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="57" mass="6192" checksum="60C58C5A9C609E16" modified="2013-03-06" version="1">MFPDGLSEDMRESLGMNKSLILSIAGTNQVDFNLKLNNGFANGYPLSFDLLSNPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L0</accession>
    <name>K9Z5L0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional pantoate ligase/cytidylate kinase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Pantothenate synthetase</fullName>
                <shortName evidence="15">PS</shortName>
                <ecNumber evidence="15">6.3.2.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">Pantoate--beta-alanine ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="15">Pantoate-activating enzyme</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Cytidylate kinase</fullName>
                <shortName evidence="15">CK</shortName>
                <ecNumber evidence="15">2.7.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">Cytidine monophosphate kinase</fullName>
                <shortName evidence="15">CMP kinase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">panC/cmk</name>
        <name evidence="17" type="ordered locus">Cyan10605_1753</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="15"/>
    <dbReference type="EC" id="2.7.4.25" evidence="15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219582.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1753"/>
    <dbReference type="EnsemblBacteria" id="AFZ53855">
        <property type="protein sequence ID" value="AFZ53855"/>
        <property type="gene ID" value="Cyan10605_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1753"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1861"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037427_0_0_3"/>
    <dbReference type="OMA" id="IDHVFLM"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01349">
        <property type="entry name" value="PanCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024894">
        <property type="entry name" value="Pantoate_ligase/cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="16">
        <location>
            <begin position="320"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pantoate--beta-alanine ligase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylate kinase" evidence="15">
        <location>
            <begin position="312"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ53855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="539" mass="59846" checksum="03BA113500D5BAED" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L2</accession>
    <name>K9Z5L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220200.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2394"/>
    <dbReference type="EnsemblBacteria" id="AFZ54476">
        <property type="protein sequence ID" value="AFZ54476"/>
        <property type="gene ID" value="Cyan10605_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2394"/>
    <dbReference type="HOGENOM" id="CLU_2218719_0_0_3"/>
    <dbReference type="OrthoDB" id="2144998at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12350" checksum="BC0C26D94A5CD0D6" modified="2013-03-06" version="1">MDLSSISLRGVEIWRIWSAHNIIEQFWKMLKSVLKIAEMKLRKQGIYIGLLIKVIMYLILLSMQFMPSLSRLSLTQIMKKIESTTKLPDVIKEHFQHDFLGVSAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q4</accession>
    <name>K9Z5Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219797.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1977"/>
    <dbReference type="EnsemblBacteria" id="AFZ54072">
        <property type="protein sequence ID" value="AFZ54072"/>
        <property type="gene ID" value="Cyan10605_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1977"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120519_0_0_3"/>
    <dbReference type="OMA" id="DPYYRFQ"/>
    <dbReference type="OrthoDB" id="1694633at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="20868" checksum="F67267980F0B37EE" modified="2013-03-06" version="1">MVLSRWFASANKINIHTNALASKIKQDPYYRFQSDLEIEIGAQLGIKIDVNIASVDDWLRLPGISITQARSLVEIINSGINFLCLEDLAAALGVSVLKIQSWQPILYFAYYADDSFHAPAKVNPNNATLNQLIKIPNLSQDIAQQILIDRESNGKYRHIADLQKRLNLTPDFAYHLMNYFQFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X6</accession>
    <name>K9Z5X6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220314.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2510"/>
    <dbReference type="EnsemblBacteria" id="AFZ54591">
        <property type="protein sequence ID" value="AFZ54591"/>
        <property type="gene ID" value="Cyan10605_2510"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2510"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118260_0_0_3"/>
    <dbReference type="OMA" id="DWQAHYY"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="247" mass="29230" checksum="4AB31EA37C5F8DD3" modified="2013-03-06" version="1">MYKNPDILWLSTNPYLMRFNLPVIKYLSQYVSIGQWEYQLTEDETTSLDLAIEFLNNYLEMVKKPVHLVGHSTCGLLGLQYANKYPEKVKSLTLLGVGINPALDWVSYYYLLRNHFKCNQEAILTHLAKYLFGYRNFYYQKSLVKILKKALIYSLSPHSLYRKCDYFSVEKTAYPLMVSGSNDDQVVFWSEIEKWKSYLKPEDYIWQCPNGEHFFHYFQAKLLGNQILSFWSSLEHSVNHKLAMKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z602</accession>
    <name>K9Z602_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220339.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2536"/>
    <dbReference type="EnsemblBacteria" id="AFZ54616">
        <property type="protein sequence ID" value="AFZ54616"/>
        <property type="gene ID" value="Cyan10605_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2536"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2691"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_3"/>
    <dbReference type="OMA" id="KLSWRVT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="243"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="377" mass="43005" checksum="241F86D6E4485543" modified="2013-03-06" version="1">MSLLLSLIIPTYNESENISPLIIQLTSLLDRTLEQKYEIIIVDDDSPDLTWKIAQDLSDQYPQLKVIRRQGEKGLSTAVMKGWEKAQGEILGVIDADLQHPPESLLQLWSEIEKGADLAVASRHVEGGGVSDWSLLRRFLSRGAQTLGLIILPGVIGRVSDPMSGFFLVRRRCLANSTLNPLGYKILIEVLAKGKIGWISEVGYVFQERQEGQSKVTKQQYIDYIRHLVRLRLSLWRFERFIRFGVVGLSGVFVDMAFLYLLSDSSTLGLPLTRSKIIAAELAIINNFLWNDSWTFRDIAQTQPGKRRKIKRFIKFNLICLAGLILNVLFLNIFYNIFDLNRYVANLGAIAIVTIWNYWLNLKLSWRSTDLDSESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z605</accession>
    <name>K9Z605_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GAF sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219730.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1907"/>
    <dbReference type="EnsemblBacteria" id="AFZ54005">
        <property type="protein sequence ID" value="AFZ54005"/>
        <property type="gene ID" value="Cyan10605_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1907"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2024"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_3"/>
    <dbReference type="OMA" id="DLPQYIC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="221"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="470"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="672" mass="76879" checksum="0DBD3DE491146F12" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z627</accession>
    <name>K9Z627_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recF</name>
        <name evidence="7" type="ordered locus">Cyan10605_2518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220322.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2518"/>
    <dbReference type="EnsemblBacteria" id="AFZ54599">
        <property type="protein sequence ID" value="AFZ54599"/>
        <property type="gene ID" value="Cyan10605_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2518"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2669"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_3"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA_15" evidence="6">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="377" mass="44311" checksum="122DA116DAA61EA4" modified="2013-03-06" version="1">MYLSKLNLNYFRNYIQSEINFSSNKIIILGNNAQGKSNLLEAIQLLSCLKSHRTNKDLDLVYRDRIYGEIKGEITRNYADYSLSILFPAKGKRELKVNYEKISRNIDFLGIVNTVLFSSLDLDLVKGSPEYRRNWVDNLLLQLEPVFSYIIKEYNHVLKQRNSLLKRLKKQGITNYEDLSQTTILELNIWENKLIENACRVMRRRKRVLDKLEPLARLWHDKISNKTEKLEIIYHPNVTYDRDDIQEIKQKIQREIEDKRNTELLMGVTLVGPHRDEIEFVINKSVARNYGSQGQQRTLVLSLKLGELQLIEQIIGETPLLLLDDVMAELDLQRQQQLLDCLGNRFQTFITTTHLNYFDERLLQEAQIIRVEKGKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z632</accession>
    <name>K9Z632_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219760.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1939"/>
    <dbReference type="EnsemblBacteria" id="AFZ54035">
        <property type="protein sequence ID" value="AFZ54035"/>
        <property type="gene ID" value="Cyan10605_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1939"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2060"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091281_0_0_3"/>
    <dbReference type="OMA" id="WIEVAPG"/>
    <dbReference type="OrthoDB" id="1374667at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="4">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="4">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="22653" checksum="F317E77CAA9915CF" modified="2013-03-06" version="1">MGVELRSYVYLDRLQPQHASYIGTVALGFLPLPGDASLWIEISPGIEINRITDVALKSAVVRPGVQFVERLYGLLEIHSSNQGEVKTAGMAILDALGVSEKDSLKPEVVSSQIIRNIDPYQAQIINRNRRGQMLLAGETLYVLEVKPAAYAALAANEAEKAALINILTVQAVGSFGRLYLGGAERDIKAGAAAALDAIANIGGRVSVSKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z663</accession>
    <name>K9Z663_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylhydroperoxidase like protein, AhpD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2554"/>
    <dbReference type="EnsemblBacteria" id="AFZ54634">
        <property type="protein sequence ID" value="AFZ54634"/>
        <property type="gene ID" value="Cyan10605_2554"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2554"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2711"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037493_2_0_3"/>
    <dbReference type="OMA" id="IMNWHEI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="450" mass="50684" checksum="25CB5C9791B0F035" modified="2013-03-06" version="1">MSYLKPLAKTEVSDQAQEILTEIENQFGMIPNLFKTYAYYPPLLKANWQKFRATMEGGTLSPKLKQTIAVLISLDNSTEYCVCAHSRALLNMGISEEELKNIRHLIEVLIMRKIITMTLGSLTFSGFILFGLIYQAGGVENFKLRYFALTGIFQDQTKELADIRSQNLNPAKNTRIELSQLLNGGPPKDGIPSIDNPVFDTSQTTPFPQNELVIGVVVNGEAKAYPLGIMNWHEIVNDTVGGTNLTITYCPLCDTIVAFERGNTTFGVSGKLYQSCLVMFDRSDDTLYSQPWALGVVGKNVNTSLNRVAAVKTTLGDWLEKYPDSKILATKTGHNRDYFRYPYGSYDTDTKLIFPVRNQEQLQLHPKAIVSYIWEENQKTPHNSFSGISQQFPHEELKKLGEKTVKFGDRTVKARWDTELNTVIVEELDGKIIPSSTAFAFVYPSFFDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z664</accession>
    <name>K9Z664_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219937.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2124"/>
    <dbReference type="EnsemblBacteria" id="AFZ54212">
        <property type="protein sequence ID" value="AFZ54212"/>
        <property type="gene ID" value="Cyan10605_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2124"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2259"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056498_0_0_3"/>
    <dbReference type="OMA" id="GKGWAVW"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="400" mass="46230" checksum="C515B474DAABD564" modified="2013-03-06" version="1">MDYKQELITTIHDFGCDINELELKLIDLTKETKTVVLIPALYEEIKRPALHIIRQELGKCQFVQTVIICVYAKTIEEYRETVQFFQSLPQKTYILWENGQRITNILECLRAKDLDLMRYKGKGKAVWLGLGLATLAGEAIALHDADIITYDKSYPLKLLYPLVEKEFGIAFNKAYYARIGENSRNLNGRAVRLFVTPLLSALTDMFGYQNYLRYLNAFRYPLSGEFALNSDLALNIRIPANWGLEIGLLAEVYRNVAEKRISQIDLGIFDHKHQKIGKSTNEGLQKMCLDILRSLFRTLTETEQVIITRDHIHALRIKYRREAQDYTRQYSLDARFNGLSYDRHQEEVIIEIFQQVIGESGEYFFADPSGALIPDWTRALAVMPDLREQLQKAVDEDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z687</accession>
    <name>K9Z687_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219815.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1996"/>
    <dbReference type="EnsemblBacteria" id="AFZ54090">
        <property type="protein sequence ID" value="AFZ54090"/>
        <property type="gene ID" value="Cyan10605_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1996"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2119"/>
    <dbReference type="eggNOG" id="ENOG5032QY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137322_1_0_3"/>
    <dbReference type="OMA" id="EIAIFQP"/>
    <dbReference type="OrthoDB" id="1900092at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18448" checksum="E93F1FE932B3B687" modified="2013-03-06" version="1">MYPELQALIHESEHQYLQQSDLDKLTQEVSTLKQRLAVYRVLRDQEISIFQAIADKLLENLPQEKTRKIETCVRHWLLVTRYGAMAMLLNNPEFLEHRLLEWLTDIVQAHEYQVISENLHSLLIKKLENVLEDDGIKYIQPFLDQAQRHITEAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z698</accession>
    <name>K9Z698_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUA5/yciO/yrdC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219982.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2171"/>
    <dbReference type="EnsemblBacteria" id="AFZ54257">
        <property type="protein sequence ID" value="AFZ54257"/>
        <property type="gene ID" value="Cyan10605_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2171"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_3"/>
    <dbReference type="OMA" id="IHELKRW"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="23568" checksum="33349F63FA4981FA" modified="2013-03-06" version="1">MSQICPKSVNIIPQIIDVLNKGEIVILHTDIVYIFLANGLNENSANKIHELKRWNPRKPLVLLSNQERISEYSNLSKDAQILVNQFPYPISVIIPHRNNLPETVTAGHNTIFVSCPDDFIYNLVNRCPFPIVSGTASLGGDYRATNAKTAQDLFGKDVSLIVDGGKPKYGIRTTLIDCSLPLPTIMNFGIISYDDLRPLLPHIELPSHLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A4</accession>
    <name>K9Z6A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219665.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1836"/>
    <dbReference type="EnsemblBacteria" id="AFZ53938">
        <property type="protein sequence ID" value="AFZ53938"/>
        <property type="gene ID" value="Cyan10605_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1836"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1949"/>
    <dbReference type="eggNOG" id="ENOG5032ZCN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172626_0_0_3"/>
    <dbReference type="OMA" id="WFAVRLE"/>
    <dbReference type="OrthoDB" id="2033123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021954">
        <property type="entry name" value="CRR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038150">
        <property type="entry name" value="CRR7-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12095">
        <property type="entry name" value="CRR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="10126" checksum="5DB051874575E0E5" modified="2013-03-06" version="1">MVDSIMYQEDGYVVLETNQPEQLLTEMELLQKLEQVIESCQDIPSDINSIDSLSEKAKYLLENYCEFNIDDDNSLQWYVVRWEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D7</accession>
    <name>K9Z6D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219865.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2051"/>
    <dbReference type="EnsemblBacteria" id="AFZ54140">
        <property type="protein sequence ID" value="AFZ54140"/>
        <property type="gene ID" value="Cyan10605_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2051"/>
    <dbReference type="eggNOG" id="ENOG503372B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2368174_0_0_3"/>
    <dbReference type="OMA" id="DEHESNA"/>
    <dbReference type="OrthoDB" id="2036005at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="9052" checksum="EB86094321EF04A8" modified="2013-03-06" version="1">MNIKYLEHKVRFLTNEKGQKTDVLIPLIVWEKLISLLNEKLSENSNTKAELIAELKQSLLDAQEGKTFPLEELWEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F2</accession>
    <name>K9Z6F2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220417.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2619"/>
    <dbReference type="EnsemblBacteria" id="AFZ54694">
        <property type="protein sequence ID" value="AFZ54694"/>
        <property type="gene ID" value="Cyan10605_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2619"/>
    <dbReference type="HOGENOM" id="CLU_1871995_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="14677" checksum="FF2E483D1333D1EF" modified="2013-03-06" version="1">MRRLNFYFSIILHSGLVACSGLVGGDPIVIEYCTEIGNSKSVCSCAAKKLKANAEEDVYSNYIQILNNTKNLSEEHNFEQEAENVDDLSGTIGILVKGTTLIFSAGEEAGLNWIETLGTLSTIEPILENAIVACGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F4</accession>
    <name>K9Z6F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220422.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2624"/>
    <dbReference type="EnsemblBacteria" id="AFZ54699">
        <property type="protein sequence ID" value="AFZ54699"/>
        <property type="gene ID" value="Cyan10605_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2624"/>
    <dbReference type="eggNOG" id="ENOG50333G6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193886_1_0_3"/>
    <dbReference type="OMA" id="DYTQERQ"/>
    <dbReference type="OrthoDB" id="2039523at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7995" checksum="1523B2EBD64BC611" modified="2013-03-06" version="1">MIPTELKQKGYQVLVKELGQVDTIRFLQEMGWGNGDYTKERQDTLKNTTRAEFWCEIEEMRKEQKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P7</accession>
    <name>K9Z6P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220588.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2799"/>
    <dbReference type="EnsemblBacteria" id="AFZ54866">
        <property type="protein sequence ID" value="AFZ54866"/>
        <property type="gene ID" value="Cyan10605_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2799"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_1_0_3"/>
    <dbReference type="OMA" id="NYAPAYE"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="41081" checksum="D623C7A505E94FCA" modified="2013-03-06" version="1" precursor="true">MEVGKVVFKTIIPQIMISLLIGGIGLFSGDLSAQAQAKASLNSQQRQQLYKLLQQGEKYVVAGNVNNALSIYRQAASLDRSNPKIFSSIGYLYASAGNFSSAVEAYQQAISLAPDNGDFYYALGYSLAQLGDDKGAIAAYEKATVVQPQKADNFVALGVLLVRNREYENVETYFQRAIALDPKNETAYDMMATALYQQEKNTEAIAFLETALKKFPYNQDLRLKLATAYFKEQDFDAGLKELKILEDSQPNNPQIIFKMGMVYEQTQDWENALQAYEKASALDNNFLQAYGGIARILEQKEDQFGAIVAYRRFLELAPQNPYGYHRLGLLLKARGRNQEAQEMLSRALTIYQQQGNNEAVAQVQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R4</accession>
    <name>K9Z6R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220161.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2353"/>
    <dbReference type="EnsemblBacteria" id="AFZ54437">
        <property type="protein sequence ID" value="AFZ54437"/>
        <property type="gene ID" value="Cyan10605_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2353"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2498"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_3"/>
    <dbReference type="OMA" id="WPGMGTF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35814" checksum="58A0EF8CFB2D99D7" modified="2013-03-06" version="1" precursor="true">MIYLGKRILISLPTLLAISIIVFIILALAPGDPLSEFASNPNITAEVRENIRKSFGLDQPIYIRYIKWLTAFLQGNLGYSFTSRSPVSDLIWQRLPNTLSIVGLAYLLSVITAIPLGVISALKRHSLFDKFSNAIALFGYSIPPFFTGLLLIIIFSVKLQWLPFIYDSNLIVNSWASFIAQIKQSIMPIIVLTLYQTAVLMRFMRSSVREELNHDYVRTAYSKGLNPYQVVINHVLRNALIPVITLIALDIPSIFTGALVTEQIFRIPGIGALLIESIYRSDTPVIMAITMIYGILIVIFNLIADLTYSWLDPRVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S4</accession>
    <name>K9Z6S4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219980.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2169"/>
    <dbReference type="EnsemblBacteria" id="AFZ54255">
        <property type="protein sequence ID" value="AFZ54255"/>
        <property type="gene ID" value="Cyan10605_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2169"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2305"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_3"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="232"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="491" mass="55323" checksum="B2592EEB5EE55AFF" modified="2013-03-06" version="1">MTISFSSLGLSESLVNQLEKIGFVTPTKIQSLAIPELLSGRDVVGQSQTGTGKTAAYSLPILDSIDRSSKDVQALILTPTRELAQQVAESLKDFIARGDRTYVLTVYGGQSIERQIRFLEKGSHIVVGTPGRIIDLLNRKNLTLDSLRYAVLDEADEMLSMGFIDDVKEILSQTPKSRQTICFSATMPKEIQYLVKEFMNDPINATGEKPQDTPSRIDQCVYMVPRGWSKIKTIQPILEIEDPQSGIIFVRTKRTASELTTKLQEAGQSVDEYHGDLSQSQRERLIQRWRDGKIKLVVATDIAARGLDVSDLTHVFNFDLPDNTETYIHRIGRTGRAGKEGKAIALVEPSDRRFLRQIERRLNQTIRVENVPNRSTVEAKRMEKLTEQIKESLAGERLASFLPLVKELHEDYDPTAIAAATLQILYDRDCPSWLQQDWDVPPPATPKPYIKKGKGGRTKYGSRGADSFDRQNKYKGKPKRSYNRSVKLNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y6</accession>
    <name>K9Z6Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220676.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2890"/>
    <dbReference type="EnsemblBacteria" id="AFZ54956">
        <property type="protein sequence ID" value="AFZ54956"/>
        <property type="gene ID" value="Cyan10605_2890"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2890"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3071"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126005_2_0_3"/>
    <dbReference type="OMA" id="VYDILEY"/>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8281" checksum="D8166EE642FBFD6D" modified="2013-03-06" version="1">MSYQNIITIESGKRSGKPCIRGMRITVYDILEYLAGGMTEAEILEDFSELTPEDIKACLAFAADREKKLFMASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z756</accession>
    <name>K9Z756_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219923.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2109"/>
    <dbReference type="EnsemblBacteria" id="AFZ54198">
        <property type="protein sequence ID" value="AFZ54198"/>
        <property type="gene ID" value="Cyan10605_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2109"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2242"/>
    <dbReference type="eggNOG" id="COG4301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_1_0_3"/>
    <dbReference type="OMA" id="RVEMHLV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38153" checksum="4EFF5F1395CBCDCC" modified="2013-03-06" version="1">MIASNQKRSIEIQYLENILPIANDGQDVIEGLSSTPKTIPAKYFYDAYGSELFEQICLLPEYYPTRTETEILQQASAEIAELTGVCELVELGSGSSTKTRLLLSAYENLGQPWQYVPIDVSSEILKESALQLHSEYPHLSILGLVGTYEQALLQLPASSLPKRMIVFLGSTLGNFTQEECDRLFNEVRDILQVGDYFLLGIDLQKPKEILEKAYNDSQGVTAKFNLNMLSHLNQRYEGNFDLDSFQHHAIYNQNEQQIEMYLRAKQVQRIQLKKLDLKIEIEVGESILTEISRKFNLEQMEEFLAQHRLKPIKYWTDEKQWFGLILSQLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B6</accession>
    <name>K9Z7B6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220355.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2552"/>
    <dbReference type="EnsemblBacteria" id="AFZ54632">
        <property type="protein sequence ID" value="AFZ54632"/>
        <property type="gene ID" value="Cyan10605_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2552"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2709"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_3"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="34809" checksum="EFB9FBF644FD9BB1" modified="2013-03-06" version="1">MVENLVIIGSGPAGYTAAIYAGRAQLNPLMFEGFSVGGVPGGQLMTTTEVENYPGFAQGITGPNLMKEMRQQAQRWGARLIREDVIKVDFSQRPFIITADETEVQALAVIICTGATAKRLHILGEEEFWNNGISACAICDGASPLFRNTEVAVVGGGDSAAEEALYLTKYASLVYLLVRRDRLRASKTMQERLFAHTQIKIHWHTVPVVAYGDEILQGIQVQNTLTKEVSEFSVNGLFYAIGHTPNTRLFQGQITLDEQGYIITKGKSTATNVEGVWAAGDVQDHHYRQAITAAGTGCMAALEAERWLSQKGSLSVPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E2</accession>
    <name>K9Z7E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220018.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2207"/>
    <dbReference type="EnsemblBacteria" id="AFZ54293">
        <property type="protein sequence ID" value="AFZ54293"/>
        <property type="gene ID" value="Cyan10605_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2207"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_5_3"/>
    <dbReference type="OMA" id="MEDAWGN"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="26416" checksum="DC9416A697DE6A1F" modified="2013-03-06" version="1">METQEFSDTFSLFHNLNTETLEWVLSMTENESYSANEVIISEDNWGKAIYLIVSGWVKLENIYHHQESITVEVTGKGGLVGEAGILDSVNTNSRITCISDVELLSISAQRFLQILYRDTQIQNRLLKMMVKRVAEYQKYCQFHRQTPKVRLTTILISLADRYGKATEKGIKLFNFGRKDLADLAQLSLEELDYIVEKLETKGLLVVESETNSLFLPNIKQLHHIIGKLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H4</accession>
    <name>K9Z7H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54530">
        <property type="protein sequence ID" value="AFZ54530"/>
        <property type="gene ID" value="Cyan10605_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2449"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2594"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_3"/>
    <dbReference type="OMA" id="PQPMLGI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="184"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="538" mass="62503" checksum="C1E8CA7699200A8A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J6</accession>
    <name>K9Z7J6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ordered locus">Cyan10605_2279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220087.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2279"/>
    <dbReference type="EnsemblBacteria" id="AFZ54363">
        <property type="protein sequence ID" value="AFZ54363"/>
        <property type="gene ID" value="Cyan10605_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2279"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2421"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_3"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="27896" checksum="9A7F5E514AB29839" modified="2013-03-06" version="1">MKVTIQNLQQWKGEKRPIVSLTAWDYAIAQLLDSAGVDLILVGDSLGMVALGHSSTLPVTLEEMIHHTKAVCRGVNRALVVCDLPFLTYQRDVSQAIESAGKIIKETNAGAVKLEGGYPAMINTVTRLTEVGIPVMAHVGLTPQSVRILGYKKQGKTPEQQEKIFHQAIALQEAGAFAIVLEHITADLAQKITKELTIPTIGIGAGNSCDGQVLVTSDLLGLSDKLPPFAKPYANLRETILTSVNYFAEDVRNRRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J9</accession>
    <name>K9Z7J9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220092.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2284"/>
    <dbReference type="EnsemblBacteria" id="AFZ54368">
        <property type="protein sequence ID" value="AFZ54368"/>
        <property type="gene ID" value="Cyan10605_2284"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2284"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2426"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075279_0_0_3"/>
    <dbReference type="OMA" id="INTWISP"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="26814" checksum="905673B1B9491C19" modified="2013-03-06" version="1">MTLSVEHQIIYPESDGQPMADNTKQFRWIVFLKENLECLFANNSNVFVAGDLLWYPQQGKPDIRVAPDVMVVFGRAKGDRGSYRQWEEDNIAPQVVFEIISPSNTMKEMLKKQQFYERYGVEEYYIYDPDRHDFTGFQRINDKLTLIDHINTWISPRLGIKFVFTQENLKVYYPDESPFLTTIELKQKADAEKQRADMEKQRADSAELELEKLKQFLQQQGIDLPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N2</accession>
    <name>K9Z7N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate ABC transporter, ATPase subunits C and D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Nitrate/nitrite/cyanate uptake transporter (NitT) (TC 3.A.1.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220878.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3106"/>
    <dbReference type="EnsemblBacteria" id="AFZ55159">
        <property type="protein sequence ID" value="AFZ55159"/>
        <property type="gene ID" value="Cyan10605_3106"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3106"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3310"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="WRTAQGN"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="32475" checksum="A893A462635E6D9C" modified="2013-03-06" version="1">MTVSTQPEYLTCLEAGDNVQLCLRNVSKVFSTKQGLFGTKKKEFVALENINLDIEYNTFVSIIGPSGCGKSTLLSIIAGLSSASGGSVMMNKEPIIGPGPDRGMVFQSYALMPWMTVEENIRFAVETVYPKMPINQQKRIVKEHLQMVGLTGASKKHPHELSGGMRQRVGIARALAINPDILLMDEPFGALDALTRGFLQEEIERIWEEHRKTVIMITHSIDEALLLSDKIIMMTKGPRAGIAQILDVPFPRPRNRFEVEDHPAYHDLKVAMEEHLYRETRAVEEARVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z800</accession>
    <name>K9Z800_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2795"/>
    <dbReference type="EnsemblBacteria" id="AFZ54862">
        <property type="protein sequence ID" value="AFZ54862"/>
        <property type="gene ID" value="Cyan10605_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2795"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2970"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101699_1_0_3"/>
    <dbReference type="OMA" id="GCFGYPR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="19294" checksum="67FE726168BA2921" modified="2013-03-06" version="1">MKFVHFFKIIICSFCLSSCSNYPRLLNFPFSDNNRSFNTRSAEFNPSISGEYITFVSDRNGSQDIYLFDARNRRLVDLPGLNAFDEVASNPSISEDGRYLVFSILAEGKSGLYLYDRTTQQKRLLIPQTKQEIRNPTISSNGEKIAFEIARNGQWDIVVTDIRGNVLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z802</accession>
    <name>K9Z802_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3275"/>
    <dbReference type="EnsemblBacteria" id="AFZ55321">
        <property type="protein sequence ID" value="AFZ55321"/>
        <property type="gene ID" value="Cyan10605_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3275"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014509_0_0_3"/>
    <dbReference type="OMA" id="EYRSVIF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="31149" checksum="E093A13A98C69E4D" modified="2013-03-06" version="1" precursor="true">MFIKTNLVQKILSTLIFFFPLNLIWANPTYAQIGVSPLVIQENTERGKAQGIINVRNTTNEPIRVRVYTEPFIYDREKGFQTVETNEADLSPYLRFSPTEMTIPPGAERRVRFLAQFPPSLPDQEYRAAIFSETLRQAQDNQQNTVGIIARIGVTVYVRKGSLQPNLTPETATYNPQDNTIRLLVKNTGEATALPKIAWQLNQNGSTIATGEAPETTVMAGSDRIINLALIEKDEATQEDKPIRLNKGQYQLSGQLVWREGNNNPNIIPFETTISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z838</accession>
    <name>K9Z838_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neutral amino acid ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220276.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2472"/>
    <dbReference type="EnsemblBacteria" id="AFZ54553">
        <property type="protein sequence ID" value="AFZ54553"/>
        <property type="gene ID" value="Cyan10605_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2472"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2621"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="28088" checksum="88390ABFA6A9E8BF" modified="2013-03-06" version="1">MPQSNDSILQAINLSKSFGGLKAVHQASIDVKNHSITGLIGPNGAGKSTLFNLLSNFLTADEGQVLFEGNPVQNLPPHQIARLGFLRTFQVARVLSRLTVLENMLLGTQNQIGEHLFSVLLQPKKIRKQERESKEKAMNILESVGLAEKAYDYAGALSGGQRKLLEMARTLMTNPKLILLDEPAAGVNPTLINQICEHILSWNQQGISFLIIEHNMDVIMSLCSHVWVLAEGTNLADGTPEEIQNNEQVLSAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z866</accession>
    <name>K9Z866_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cyanobacterial UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">UDP-Glc PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cugP</name>
        <name evidence="3" type="ordered locus">Cyan10605_3293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CugP-type UDP-glucose pyrophosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3293"/>
    <dbReference type="EnsemblBacteria" id="AFZ55339">
        <property type="protein sequence ID" value="AFZ55339"/>
        <property type="gene ID" value="Cyan10605_3293"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3293"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3508"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_2_3"/>
    <dbReference type="OMA" id="PFLTHQL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002134">
        <property type="term" value="F:UTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02085">
        <property type="entry name" value="CugP_cyano"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037538">
        <property type="entry name" value="CugP_cyano"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="42340" checksum="D343093E151ABC7D" modified="2013-03-06" version="1">MILAAGKGTRVRPITHTIPKPLIPILQKPVMEFLVELLRQHGFKQIMVNVSHLAEEIENYFRDGQRFGVEIGYSFEGRIIDGELVGEALGSAGGLKKIQEFNPFFDDTFVVLCGDALIDLDLTEVVRQHKAKGAIATVVTKSVPKDAVSSYGVVVSDENGKILTFQEKPSVEDALSTEINTGIYVFEPEVINYIPPNQEYDIGSELFPKLVQLNLPFYAVNMDFEWVDIGKVPDYWEAIRAVLRGDVKNVQIPGKEVRPGVYTGLNVSVNWDKVDITGPVYIGAMTHIEDGAKIVGPSMIGPNCWICEGATVDNSVIFEYSRLGSGVYLQDKLVFGRYCVDKTGTAIDVQAAAIDWLITDTRQETVSHHNKGQVISNFVTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z882</accession>
    <name>K9Z882_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220311.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2507"/>
    <dbReference type="EnsemblBacteria" id="AFZ54588">
        <property type="protein sequence ID" value="AFZ54588"/>
        <property type="gene ID" value="Cyan10605_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2507"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2657"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_3_3"/>
    <dbReference type="OMA" id="QMPYGDQ"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02522">
        <property type="entry name" value="GT_2_like_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04283">
        <property type="entry name" value="glyco_like_mftF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26463" checksum="C5036364CCF9F385" modified="2013-03-06" version="1">MNLPLKISIIIPVINEEKMLLKTIPILKQYPYVEILFVDGGSQDNTINLIHQAGFKCLSSPILNRSYQMNLGAESAQGDILLFLHGDTILPHNFPQIIIDIVSNSNFIAGAFLLKIDSDKIIFRLLEIMIKMRSHLFSLPYGDQGIFIKKKIFEKIGGFKNLAIMEDFELIKRLNKKGKIYISSEAVITSARRWEKLGIFKTTLINQLIVIGYYLGINTKKLANFYRQIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A1</accession>
    <name>K9Z8A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220326.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2522"/>
    <dbReference type="EnsemblBacteria" id="AFZ54603">
        <property type="protein sequence ID" value="AFZ54603"/>
        <property type="gene ID" value="Cyan10605_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2522"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2674"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_2_3"/>
    <dbReference type="OMA" id="CTAMVLM"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="377" mass="41998" checksum="D5F5ECD904EA7160" modified="2013-03-06" version="1">MGKSLNKCAEKAGSDLSFFEKYLTLWILICIVIGIGLGRIFPSLAQNLDLLNVYNVSIPIAICLFFMMYPIMVKIDFSQAVKAVKTPKPVILTLVVNWLIKPFSMVIFAQFFLGWLFAGWLQETEIIRGVEVSLSNSYIAGCILLGIAPCTAMVLMWGYLSYSNQAHTLVMVAVNSLTMLLLYAPLGKWLLSANDLIVPWQTIVLSVIIYVGLPLITALLSRYWIFKYKGRQWFENRFLSYLTPISITALLATLILLFAFKGELIINNPFHIILIAIPLLVQTNFIFLITYAIALKLDLVYEDAAPTALIGASNHFEVAIATAVMLFGLNSGAALATVVGVLIEVPVMLFLVEICKKTASWFKRDPEKATLLDPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B4</accession>
    <name>K9Z8B4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220543.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2751"/>
    <dbReference type="EnsemblBacteria" id="AFZ54820">
        <property type="protein sequence ID" value="AFZ54820"/>
        <property type="gene ID" value="Cyan10605_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2751"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2921"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_3"/>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="27671" checksum="C5B458EEAEE7AEBA" modified="2013-03-06" version="1" precursor="true">MRYTIALFLAVLVGLSLGLIGGGGSILAVPILKYVVGVTAKEAIAMSLFIVGIVSIVGLIPHWQQKNVNLPVALGFIPPAMIGAFLGSKITTLSFITDTIQLVSFAIIMLLASILMIKKSSKKNKDKKEENSEKITSKNKIYQKIILTTFQGFGVGVLTGFVGVGGGFLIIPCLVLVGGIPMKEAVGTSLLIIATNSASAFLGYLNQVELNWFVMITFSLFASLGIIIGAKLSQTIEAKSLQKAFGYFVLVVAVFILIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C4</accession>
    <name>K9Z8C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220701.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2920"/>
    <dbReference type="EnsemblBacteria" id="AFZ54982">
        <property type="protein sequence ID" value="AFZ54982"/>
        <property type="gene ID" value="Cyan10605_2920"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2920"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3107"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189056_0_0_3"/>
    <dbReference type="OMA" id="ERYTMGY"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="27002" checksum="71632FF55CE0F990" modified="2013-03-06" version="1">MNYYEILEIKHNASAQEIKQAYRRLAKKFHPDSQNNNADHEKIVSLNAAYEILSDPENRHIYDQTLKQNRADSVQYRHGKSNSASEFYRYNRQQQKDTEFSQFQWLQEVYFPVKNLINSIVSPLEMEIEELSADIFDDELMSFFMEYLENCQQACNQAQNILTSQKNPSLYAGIAANLYYGLNHLNDGLEELNRFTQTYDESYLHTGRELFYLAEEINQVAEEMAEKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L9</accession>
    <name>K9Z8L9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221227.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3473"/>
    <dbReference type="EnsemblBacteria" id="AFZ55509">
        <property type="protein sequence ID" value="AFZ55509"/>
        <property type="gene ID" value="Cyan10605_3473"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3473"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3698"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098557_0_0_3"/>
    <dbReference type="OMA" id="SRTRFNN"/>
    <dbReference type="OrthoDB" id="1161864at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="25292" checksum="E6BC6D78234238AF" modified="2013-03-06" version="1">MLLALEKINVLEGQTLVINDVDWKQFEQILEELGEKRNSRIAYHHNILKIMTPSLEYERDKVLISTLLEIILEELDIDFCLGSTTFKSEILQKGLEPDNCFYIQNEAKIRGKKRIDLTIDPPPDLALEVDLTSRTYPHIYSALGVPELWRFEKGNLQINVLKNGQYIEVESSPICPNIPLKNLIPEFLNQCKTQGRNKTVRAFRTLIKDYTIHNGKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M9</accession>
    <name>K9Z8M9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fructose-1,6-bisphosphate aldolase</fullName>
            <shortName evidence="8">FBP aldolase</shortName>
            <ecNumber evidence="8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220801.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3023"/>
    <dbReference type="EnsemblBacteria" id="AFZ55082">
        <property type="protein sequence ID" value="AFZ55082"/>
        <property type="gene ID" value="Cyan10605_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3023"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3221"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_0_3"/>
    <dbReference type="OMA" id="NNMEIVQ"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006412">
        <property type="entry name" value="Fruct_bisP_Calv"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01521">
        <property type="entry name" value="FruBisAldo_II_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="6">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="38877" checksum="40C83402B3619AA7" modified="2013-03-06" version="1">MALVPMRLLLDHAAENDYGIPAFNVNNLEQILAIMNAANETDSPVILQASRGARSYAGENFLRHLILAAVETYPHIPVAMHQDHGNSPATCYSAIRNGFTSVMMDGSLQEDAKTPSSFDYNVSVTAEVVKVAHSVGASVEGELGCLGSLETGMGEAEDGHGFEGKLDHSQLLTDPDEAVEFVERTQVDALAVAIGTSHGAYKFTRKPTGEILAISRIEEIHAKLPNTHLVMHGSSSVPQEWLEMINQYGGQIRETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAAAKDPSNFDPRHFMKPSMKYMKQVCADRYQQFWTAGNASKIKQISLDEFAAKYAKGELSAKTTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N2</accession>
    <name>K9Z8N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease RNase T and DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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        <property type="gene ID" value="Cyan10605_2629"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2793"/>
    <dbReference type="eggNOG" id="COG0847">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334545_0_0_3"/>
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    <dbReference type="OrthoDB" id="239951at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="843" mass="98258" checksum="09EEB1E5D5E0353F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P3</accession>
    <name>K9Z8P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2644"/>
    <dbReference type="EnsemblBacteria" id="AFZ54718">
        <property type="protein sequence ID" value="AFZ54718"/>
        <property type="gene ID" value="Cyan10605_2644"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2644"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_0_1_3"/>
    <dbReference type="OMA" id="PYEIGDM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="40152" checksum="9EAA77A2FAF0AB90" modified="2013-03-06" version="1">MMSFLNWQLLSSFLIPFLTVLLAGLIGFVIENRLQKFRQNLELQPDRFLGKYSFIIKSFRGVILTWSIVGAIALMLPGINIPSTLNILIEKILIVIALTMGTILVSRLAVNLIQLYSLENETAVSLTSLFEYLTKVLIFSIGFLIIIQSIGIKITALITAFGIGSLSIGLAFQNTLSNLISGVNIIVSRKIRPGDYIQLKDGEEGYVQDVELKYTLIKDIYNNIIVIPNAKIIDASFKNYTLDSSSILITIKIGVSYDSNLEKVEKVTLEVAKSILENTEGGDKEFEPFLRYENFDYFAINLTVYLKINEYFDKFIITHEFMKAIHHKYQEENITMAYPLKYYGASGEIMNNNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R4</accession>
    <name>K9Z8R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220704.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2923"/>
    <dbReference type="EnsemblBacteria" id="AFZ54985">
        <property type="protein sequence ID" value="AFZ54985"/>
        <property type="gene ID" value="Cyan10605_2923"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2923"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3110"/>
    <dbReference type="eggNOG" id="ENOG5032ZZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185216_0_0_3"/>
    <dbReference type="OMA" id="VNGCVLG"/>
    <dbReference type="OrthoDB" id="1999935at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7672" checksum="C40FBDF00346ED0A" modified="2013-03-06" version="1">METKKVNCQIECVNGCILGEECPNQTYVKETANFIENTSLDKMLEMAEIARLKKLTEPPKWVIPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W4</accession>
    <name>K9Z8W4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ordered locus">Cyan10605_3109</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220881.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3109"/>
    <dbReference type="EnsemblBacteria" id="AFZ55162">
        <property type="protein sequence ID" value="AFZ55162"/>
        <property type="gene ID" value="Cyan10605_3109"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3109"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3313"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_3"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="427"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="627"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ55162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="664" mass="76435" checksum="DFDCD442038C07EF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X0</accession>
    <name>K9Z8X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GAF sensor hybrid histidine kinase</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2985"/>
    <dbReference type="EnsemblBacteria" id="AFZ55045">
        <property type="protein sequence ID" value="AFZ55045"/>
        <property type="gene ID" value="Cyan10605_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2985"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3179"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_17_3"/>
    <dbReference type="OMA" id="PLTCIIG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="200"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="400"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="648"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="769" mass="88961" checksum="B3E0D369D9FB4942" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z918</accession>
    <name>K9Z918_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ordered locus">Cyan10605_3151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220920.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3151"/>
    <dbReference type="EnsemblBacteria" id="AFZ55202">
        <property type="protein sequence ID" value="AFZ55202"/>
        <property type="gene ID" value="Cyan10605_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3151"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3358"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_3"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="430"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="649" mass="72709" checksum="6A17D11C9A413D1A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z943</accession>
    <name>K9Z943_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease YjgP/YjgQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220630.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2841"/>
    <dbReference type="EnsemblBacteria" id="AFZ54908">
        <property type="protein sequence ID" value="AFZ54908"/>
        <property type="gene ID" value="Cyan10605_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2841"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3019"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_1_3"/>
    <dbReference type="OMA" id="WFTSKLA"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="386" mass="43316" checksum="8EC3D68F79702C3C" modified="2013-03-06" version="1">MDKEPKFFLPLPKISVMDRYVTVELLLPFLFGIGLFTSLGLSIGTLFELIRKVTESGLLLSVAFKILFLRMPGFIALAFPMSLLLATLMAYSRLSSDSEIIALRSVGVNIYRLVIPAVILSLCVTGMTFFINDVVTPSANREATLTMQRALNRVRPTFKDRNILYPEYKTVQYDDGSRHSVLERLFYAQEFNGEEMKDLTILDLSREGLNQILTAKTATWNIGDNVWDFFNGTIYLISPDGAYRNIVRFEHQQLALSRAPLDLAQRPPNPDEMSISQAREYLEVVKLQADEKEIRKMMVRIQGKISLPFVCVVFGLIGSALGLRPQNTNKATSFGICVGLIFSYYLLSFVSESMGIWGILTPLMAAWLPNLLGLGVGTWLLVQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K1</accession>
    <name>K9Z9K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(20/20a) synthase</fullName>
            <ecNumber evidence="6">1.3.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DusA-like U20-specific dihydrouridine synthase</fullName>
            <shortName evidence="6">U20-specific Dus</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53340"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53336"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Dus family. DusA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.91" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220973.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3207"/>
    <dbReference type="EnsemblBacteria" id="AFZ55255">
        <property type="protein sequence ID" value="AFZ55255"/>
        <property type="gene ID" value="Cyan10605_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3207"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3419"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_2_1_3"/>
    <dbReference type="OMA" id="LIYPYVD"/>
    <dbReference type="OrthoDB" id="1320183at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02041">
        <property type="entry name" value="DusA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="PTHR42907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00742">
        <property type="entry name" value="yjbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="9">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="38093" checksum="44E4043064A0935A" modified="2013-03-06" version="1">MLTLTPNSELRTPNPYYRVSIAPMMDYTDRHFRYVMRVLTKHTLLYTEMITTQAIIHGDRTKLLDFSPEEKPVALQLGGDNPQQLAECAKIGADWGYDEINLNVGCPSSRVQNGNFGACLMAQPDTVARCVEAMNKAVNIPVTVKHRIGIDDQDSYGDLLNFIKIVSSTGCDRFIIHARKAWLQGLSPKENREIPPLRYEDVYQIKQDLPHLTIEINGGIKTIEATKQHLTKVDGVMIGRAAYDNPYLFASIDQEIYGSSEPIKTREEIVESLYPYIDLWTSRNLKLNTIMRHTLQIFAGQPGSKIWKRHLSEKGNSRDVGSQVVRQGLQLRKESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S2</accession>
    <name>K9Z9S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221048.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3284"/>
    <dbReference type="EnsemblBacteria" id="AFZ55330">
        <property type="protein sequence ID" value="AFZ55330"/>
        <property type="gene ID" value="Cyan10605_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3284"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3499"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_3"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="345" mass="36784" checksum="E3EF880311DCBD6F" modified="2013-03-06" version="1">MKDSLIIIRSRFPSFSLWLDGRVPKTISILIILSLIVITVSISYGEYYISPVNVIKTLLGFDTPSDFQFIINTLRLPRTLTAWLVGIGLAIAGCIMQTITRNPLADPSIIGINAGAGLAAVLFIVVFPSLPIALLPFSAFMGGILVALAIYAIAWKGDNSIIRLILVGIGFNFIVSAITNIITTFGEINSVSQALVWLTGSVYGKTMTQVLILLPWIVIFSVVTWIMSKELNSLHLGENLGKGLGLPLQKTQLTLLISGVALSSASVAIAGAVGFVGLIAPHMARFLVGNTHQGLIPVTGLIGGLLVVSADLFGRLLFTPLELPCGIITAIIGAPYFIFLLSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W2</accession>
    <name>K9Z9W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrate ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220877.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3105"/>
    <dbReference type="EnsemblBacteria" id="AFZ55158">
        <property type="protein sequence ID" value="AFZ55158"/>
        <property type="gene ID" value="Cyan10605_3105"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3105"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3309"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_1_3"/>
    <dbReference type="OMA" id="RYLAMDV"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005889">
        <property type="entry name" value="NtrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01183">
        <property type="entry name" value="ntrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="84"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30590" checksum="087FD77A874D0743" modified="2013-03-06" version="1">MTIVQGRSPQNKFKQLLDNENVQALGIFLLSLGIFLLVWELGANAKIFAKGMPSASLTLKELWWWLTNPFFNNGPNDMGIGWNLLISLRRVAIGYIMASVVAVPLGILLGMSKIATKAFNPYVQLLKPVSPLAWLPLGLYLFRDSEKTGIFIILISSIWPTLVNTAFGVSKVNSDYLDVAKTLGASKWRTIFKVIIPAALPNIISGLRISMGISWLVIVAAEMLLGTGLGYFIWSEWNNLYLPNIIVAIIIIGLVGLLLDQIFAYLEKMVSFGKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9YYZ2</accession>
    <name>K9YYZ2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217898.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0005"/>
    <dbReference type="EnsemblBacteria" id="AFZ52166">
        <property type="protein sequence ID" value="AFZ52166"/>
        <property type="gene ID" value="Cyan10605_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0005"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.6"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_3_3"/>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="305" mass="33331" checksum="13BDF0D58E2166C5" modified="2013-03-06" version="1">MKIAITGATGFIGEKLVSKLAIQHQIVIFTRSIEKAKSAFKASLLSNLEFVSYTPKQAGEWQKKIDGCDAVINLAGAPIAERWTTDYKREILESRQLGTRMIVEAISQGENKPKVLINASAIGYYGTSETETYTEISPAGNDFLAEVCQSWENEAQKVTSEGVRLVIFRLGIVLGNGGALAKMIPPFKIFAGGPIGSGKQWFSWVHIDDVVNMIENALTSDNIEGTFNATAPYPVTMNQLCETLGNVLKRPSWLPVPSIALELLLGDGAKVVLEGQKVLPQKTQEVMNYDFQYSNLKSALEDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ76</accession>
    <name>K9YZ76_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_MAE_28990 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217968.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0075"/>
    <dbReference type="EnsemblBacteria" id="AFZ52236">
        <property type="protein sequence ID" value="AFZ52236"/>
        <property type="gene ID" value="Cyan10605_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0075"/>
    <dbReference type="eggNOG" id="ENOG5030GMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782373_0_0_3"/>
    <dbReference type="OMA" id="RNEAAHG"/>
    <dbReference type="OrthoDB" id="1229807at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040788">
        <property type="entry name" value="HEPN_MAE_28990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18737">
        <property type="entry name" value="HEPN_MAE_28990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_MAE_28990" evidence="1">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="365" mass="42943" checksum="C31FA7CC26E6177B" modified="2013-03-06" version="1">MNKFIQKLQNLLDKVDNNIQSIKEITTKNQKLTDIIFGNDSTVKNILKENNQLDLTKSSVGFDQWKRYQHCSVITQLYAIYEDFVEELISIWIDNLPNIFEKYSDLGMDFQKQYILGIAKLIKRLNRNKYPELKLEKLINIPKNTNINYKLVQEVFTDHQYNLRMSELNKLLDNAGIKNTSDWLQKSNSIQQSISSINSNQTTVEKELQRFINYRNDASHNIQQDNILNFNELIDFCNFINTICFSLHDLILYQTLERMIALNKIITLGQIRQYRDKLKSARLKVNNSILLSVGLPTLLVKKETSICKFAKIEKISIVSNDQYIEKEDIKVPEKEQDIWIQFNIDARKNWTVYIFNFDKLDSGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZA4</accession>
    <name>K9YZA4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
            <ecNumber evidence="3">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60492"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.6.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mg-chelatase subunit H family.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217966.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0073"/>
    <dbReference type="EnsemblBacteria" id="AFZ52234">
        <property type="protein sequence ID" value="AFZ52234"/>
        <property type="gene ID" value="Cyan10605_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0073"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.75"/>
    <dbReference type="eggNOG" id="COG1429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002017_1_2_3"/>
    <dbReference type="OMA" id="WPETIAC"/>
    <dbReference type="OrthoDB" id="8025at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011771">
        <property type="entry name" value="BchH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022571">
        <property type="entry name" value="Mg_chelatase_H_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11965">
        <property type="entry name" value="DUF3479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02025">
        <property type="entry name" value="BchH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3479" evidence="10">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150230" checksum="EA662C70265DEB68" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZR7</accession>
    <name>K9YZR7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ordered locus">Cyan10605_0298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218178.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0298"/>
    <dbReference type="EnsemblBacteria" id="AFZ52446">
        <property type="protein sequence ID" value="AFZ52446"/>
        <property type="gene ID" value="Cyan10605_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0298"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.310"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_3"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="11"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="34827" checksum="0372BCB092E1EF3B" modified="2013-03-06" version="1">MNATVDNENTIVIGSRKSQLALVQTYWVKKELENSFPDIEFEVEKMSTQGDKILDVALAKIGDKGLFTKELEVGMLNGDVDFAVHSLKDLPTNLPEGLMLGCVTQRVNPADALVVHEKHKDKQLETLPEGSVIGTSSLRRLAQLRHHFPHLTFKDVRGNVNTRLAKLDAGEYDAIILAVAGLERLGMGDRIHQVIPAEISLHAVGQGALGIECRTGDEKVLQIIKSIEDPNTRDCTLAERSFLRVLEGGCQIPIGVNSSLEGDNLTLIGMVASLDGQKLLKDSVTGDRTQAEKLGADLADKLKQQGAGEILAEILAEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z040</accession>
    <name>K9Z040_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218265.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0390"/>
    <dbReference type="EnsemblBacteria" id="AFZ52534">
        <property type="protein sequence ID" value="AFZ52534"/>
        <property type="gene ID" value="Cyan10605_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0390"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.413"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_3"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="111"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35339" checksum="07C7C319922D1867" modified="2013-03-06" version="1">MTENTQTIALPNIESAIALAGIQEENLQFIARHTGANLILRGQDLVIYGKEKPVQRSMDVVNFLKPYWDTAKSITQPDILTAFQALDTGRVEEYQDIQNDVLAKTRHGELIRAKTFRQRQYVKAIKKYDITFGIGPAGTGKTFLGAVIAVQALLNGECDRLILTRPAVEAGEKLGFLPGDLQQKVNPFLRPLYDALYEFIEPIKIPDLMERGKIEVAPLAYMRGRTLSNAFVIVDEAQNTTPAQLKMVLTRLGFGSKMIVTGDITQTDLPSHQESGLVVATKILKNVEGIGFCYLTQADVVRHPLVQKIVAAYEKEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0C7</accession>
    <name>K9Z0C7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="7" type="synonym">rps5</name>
        <name evidence="12" type="ordered locus">Cyan10605_0509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218382.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0509"/>
    <dbReference type="EnsemblBacteria" id="AFZ52651">
        <property type="protein sequence ID" value="AFZ52651"/>
        <property type="gene ID" value="Cyan10605_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0509"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.539"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_3"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19200" checksum="B8D29D3BC09BE5A3" modified="2013-03-06" version="1">MAKEQERKGKQRKRNKEKKDNSWQERVVQIRRVSKVVKGGKKLSFRAIVVVGNEKGQVGVGVGKAGDVINAVRKAVSDGKKHIVNVNINKSNSITHVSTGMAGGAQVFMRPAAPGTGVIAGGAVRTVLELAGIKNILAKQQGSNNPLNNARAAINALQQIRSFSSVAKERDIPLEQIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W1</accession>
    <name>K9Z0W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218530.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0661"/>
    <dbReference type="EnsemblBacteria" id="AFZ52799">
        <property type="protein sequence ID" value="AFZ52799"/>
        <property type="gene ID" value="Cyan10605_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0661"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.697"/>
    <dbReference type="eggNOG" id="ENOG5031R2B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148613_0_0_3"/>
    <dbReference type="OMA" id="QKSGDYR"/>
    <dbReference type="OrthoDB" id="1769065at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12352" checksum="97D1F5ED082E524B" modified="2013-03-06" version="1">MRPNRTSTTQMEVTSIRLEKTLKDSLKSLSGSQGYQTLIRDILWNYVQQKSGEYRPNFSKTDIRSTVAATARKDESCVLTGKLIPEGEEMLLALTIHGDFVPVSVDAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z117</accession>
    <name>K9Z117_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218627.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0763"/>
    <dbReference type="EnsemblBacteria" id="AFZ52896">
        <property type="protein sequence ID" value="AFZ52896"/>
        <property type="gene ID" value="Cyan10605_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0763"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.803"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062525_0_0_3"/>
    <dbReference type="OMA" id="HLVWEQR"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="276" mass="31393" checksum="8AD9569806654965" modified="2013-03-06" version="1">MTDYWSIFNSLGKITIFLTVWAVIWVPIALPLIKLIKWPNTAPNENTSKKLTLIFSLYLLIPFLILGLTKIEGITLEQIGIIFQVRLFKSILFGYALSIFTLFLIYFWEWGLNWITWKSIINQPQRPSLLTTLPLLGFVSIFIASIEELVFRGIFVNFLKEDFSLWLTAIISSLIFALLHLVWEQKNTIPQLPGLFILGLVLFYARIVDDNLLGLAIGLHGGWVLCLAAIDSFNLIDYNSKLPSWIIGNKNQPLGSIAGLLLVLFALLLIYLNHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z120</accession>
    <name>K9Z120_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217987.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0096"/>
    <dbReference type="EnsemblBacteria" id="AFZ52255">
        <property type="protein sequence ID" value="AFZ52255"/>
        <property type="gene ID" value="Cyan10605_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0096"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.98"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_3"/>
    <dbReference type="OMA" id="YFNHEMA"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="385" mass="43200" checksum="0475AD2C26B53ED7" modified="2013-03-06" version="1">MRADNIQLPLIPIINELIINNPNTISLGQGVVFYPPPDETFKEIDKFAGNPQNNLYQSINGINKLLEEIETKLAQDNQINYSQNRSSIFVTAGSNMAFMNAVLAITNPEDEIIILAPYYFNHEMAIRLANCKPIIVDTNNQYQPDIDQIINAITPKTKAIVTISPNNPTGVVYSKKDLLAINIICKEKGIYHISDEAYEYFTYNGIKHYSPASFVDSDNHTISLFSLSKAYGFASWRIGYMVIPKHLEMAVKKIQDTILICPPVISQYGAYGALKIGKNYCQKYLLEINKVREKMLDSLAKISNICEVSKSDGAFYLFLKIKSDMNSFELTKKLIENYRVAVIPGTTFGVENKCCLRVAYGALNYDTASIGINRLVEGLSQLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z130</accession>
    <name>K9Z130_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218642.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0778"/>
    <dbReference type="EnsemblBacteria" id="AFZ52911">
        <property type="protein sequence ID" value="AFZ52911"/>
        <property type="gene ID" value="Cyan10605_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0778"/>
    <dbReference type="HOGENOM" id="CLU_2069186_0_0_3"/>
    <dbReference type="OMA" id="ICDVEDI"/>
    <dbReference type="OrthoDB" id="2075562at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13458" checksum="FEE4FF6F029579D7" modified="2013-03-06" version="1">MKHESGNSDGICDVEDIYLSSQDEQLVSFLQTHCPPPPEELKPCEDLIMMSILTEKQQPQKNKQWRWFILPSAILTAILLVSAYIFKPNFSPQMASDHDEEIEAFMINGWQGSMALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z138</accession>
    <name>K9Z138_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52879">
        <property type="protein sequence ID" value="AFZ52879"/>
        <property type="gene ID" value="Cyan10605_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0746"/>
    <dbReference type="eggNOG" id="ENOG5031XG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668548_0_0_3"/>
    <dbReference type="OMA" id="AYPFLAT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938578" evidence="1">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="411" mass="46604" checksum="C6282B7F84BFA0B9" modified="2013-03-06" version="1" precursor="true">MKKSLAYLSLFLSSLLTIINGINVPISATDDLNTISLINNYKDILSMDNSPLKVIILTNLALKYARQNNQKKALKILAKAQQISLQLTDNYQQIVSLTRVAQTYGEISKRESALASLNLAKEKTKQIKDKSLQASLLLNIALEYEKLGKIETANNIYQQSQTIKAQISQPQLEFPFEQTPTKFQIGLLANVNSFRNTTATFGFDVNYEKQWEISDILLNGAVFIGYDSDRTFNKFRPTGLINSVYRHHFDKEWSFFTNALITANQEFFASQNDDDDLSILGNLLFGGGYNLWRGETPSNSVDLQLGLGGIYEYDFFDGEKRRNQLSPALGILLQSRGFKLGNAELNHILAIIPALNDLENYTITSDSNLSIPLSEKWSFTNRLFVRYRNQLIEKDNPKVQFFFSTGVQYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z174</accession>
    <name>K9Z174_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218645.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0781"/>
    <dbReference type="EnsemblBacteria" id="AFZ52914">
        <property type="protein sequence ID" value="AFZ52914"/>
        <property type="gene ID" value="Cyan10605_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0781"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.822"/>
    <dbReference type="eggNOG" id="ENOG5032Y50">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193736_0_0_3"/>
    <dbReference type="OMA" id="YKGFVQR"/>
    <dbReference type="OrthoDB" id="2032781at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021659">
        <property type="entry name" value="NdhS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35494">
        <property type="entry name" value="PTHR35494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11623">
        <property type="entry name" value="NdhS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7005" checksum="191F8293CC8E7FD5" modified="2013-03-06" version="1">MIILPGTTVTVTNPDDIYYRYQGLVQRVTDGKAAVLFEGGNWDKLITFNLSELEIFDPKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z175</accession>
    <name>K9Z175_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon dioxide concentrating mechanism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218687.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0824"/>
    <dbReference type="EnsemblBacteria" id="AFZ52956">
        <property type="protein sequence ID" value="AFZ52956"/>
        <property type="gene ID" value="Cyan10605_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0824"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069354_0_0_3"/>
    <dbReference type="OMA" id="TLFPHRQ"/>
    <dbReference type="OrthoDB" id="1411505at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="24898" checksum="4EA374D46842012C" modified="2013-03-06" version="1">MSLPILQASTNQTTHVRGDVMIDSSVMIAVGVILNATPGNKIIIHSGVCLGMGTVITAHDGDVEIKPNAILGAGCLIFGHCIIGSQASLGSSVTVYNVNVDAGDVIPAGSIRGDRTRKIELNSQENSNSVAENKVQENKWSNKSAKSEENKQNITNNQEERESKAESISEKPEQIKQENQDISHENLEQEEEIKTDSWQEDTPPNSEQVVGKVYINKLLFTLFPERNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z182</accession>
    <name>K9Z182_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218223.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0345"/>
    <dbReference type="EnsemblBacteria" id="AFZ52492">
        <property type="protein sequence ID" value="AFZ52492"/>
        <property type="gene ID" value="Cyan10605_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0345"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.361"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073559_0_0_3"/>
    <dbReference type="OMA" id="IWSEGAI"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28847" checksum="8A0F23F2D630A51E" modified="2013-03-06" version="1">MEDYQLLIDLHKNAYRQGPGGDTESKKALDLGMLDKSQPLKIADIGCGTGASTLLLGNLLDAQITAVDFLQDFLDILNTRAKNSGLAEKISTLCCSMENLPFEDEEYDVIWSEGAIYNMGFEKGVIDWNRYLKVGGLLVVSEITWISNSRPLEVQQYWEKEYPEIDVSSSKIKILEKNGYSPIGYFVLPEHCWLDNYYQPMQNNFQDFLMRNGNSEDARAIVEAENKEIELYKKYKNYYSYGVYIAKKLHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A8</accession>
    <name>K9Z1A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S13 D-Ala-D-Ala carboxypeptidase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218248.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0372"/>
    <dbReference type="MEROPS" id="S13.002"/>
    <dbReference type="EnsemblBacteria" id="AFZ52517">
        <property type="protein sequence ID" value="AFZ52517"/>
        <property type="gene ID" value="Cyan10605_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0372"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.392"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074532_0_0_3"/>
    <dbReference type="OMA" id="SGYMNHP"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939039" evidence="2">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="32702" checksum="5427B35B1F6DC345" modified="2013-03-06" version="1" precursor="true">MPKKRHLLNWFSILTLTTTSSVSAQTILPELNNFEPIPQSVPASITPQSILIPVPPPQQSQPVGTCNAFIAPAIEEVIKRYGGGWGILVERLSDGEVLYHYNADRGFIPASNMKILTTAAALQRLAPETNISANKSLKEWVEVTNLRSNNYYADTLLKRIGGGATAKQILANMGINPSGFHFADGSGLSRRNLATPRILVDTLRVMYSSPQRDLFFASLPTAGMSGTLRNRMKQTPVQGIVHAKTGTLTGVRALSGYLDHREYGTLIFSILANDSRQSGTALVRAIDEIVLILNTTSRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C6</accession>
    <name>K9Z1C6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218263.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0388"/>
    <dbReference type="EnsemblBacteria" id="AFZ52532">
        <property type="protein sequence ID" value="AFZ52532"/>
        <property type="gene ID" value="Cyan10605_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0388"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137945_0_0_3"/>
    <dbReference type="OMA" id="EWQQITN"/>
    <dbReference type="OrthoDB" id="1875011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025564">
        <property type="entry name" value="CAAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033344">
        <property type="entry name" value="CURT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222">
        <property type="entry name" value="PTHR33222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14159">
        <property type="entry name" value="CAAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CAAD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="15943" checksum="4F6D2DEEF4CA700D" modified="2013-03-06" version="1">MESKVQDMETKQETMEKKISNDVPGMMTTTGKSAGDSSWQEYVDLVVDFLAKVPEQLGSFFSDYQKPLTTTGLIVASAITVYITLSVLDAIDNIPLLSSILELVGLGYSVWFVTRYLLKASTRQELFSEFDSLKQQVLGGKADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G6</accession>
    <name>K9Z1G6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218152.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0270"/>
    <dbReference type="EnsemblBacteria" id="AFZ52420">
        <property type="protein sequence ID" value="AFZ52420"/>
        <property type="gene ID" value="Cyan10605_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0270"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.280"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_3"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="29114" checksum="8957408EA6F79AAB" modified="2013-03-06" version="1">MNLKQNLIELPSDLNAKIIPHHVAVIMDGNGRWAKRRGFPRIVGHQKGVDTLKSLLRCCDDWGIKVLTAYAFSTENWGRPVTEVEFLLTLFERVLRKELAQMMEKNVKIRFIGDLKALPESLQAEIYHSMEETKYNKGIKFNIATNYGSRQEILQACRTIASSVQEGKINLEDIDEELFESHLYTNGLESPDLLIRTSGEMRLSNFLLWQMAYSEIYVTNTLWPDFNREEFHLALLNYQQRDRRFGKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J0</accession>
    <name>K9Z1J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217940.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52208">
        <property type="protein sequence ID" value="AFZ52208"/>
        <property type="gene ID" value="Cyan10605_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0047"/>
    <dbReference type="eggNOG" id="ENOG502ZNNY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076343_0_0_3"/>
    <dbReference type="OrthoDB" id="1927043at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29299" checksum="D516B0B0AD3608F6" modified="2013-03-06" version="1">MILVFELTTILSGCTRDWTKFSDKGECYLPEVVLQELNFLTQRAITPKDEKIAREFSRFFPDSGWQITSTMSSHPALTAKDGESISKKARLSIAIAESVYDLALRHSEQIVIFVTNDGNLKRELNQIGQTNLAIISSSQLKQWIRADETPQAVQDVMENLSFQENNQVSSHNSLKTSKLKGISSSLGKTNNAKNLNSRKVQSQRNLQRNTGDNIFSIIKSGFLTVATLITTIGVAWYFIAPQSFWKTWEGIGLPPLEIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q1</accession>
    <name>K9Z1Q1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="7" type="synonym">rpl18</name>
        <name evidence="8" type="ordered locus">Cyan10605_0510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218383.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0510"/>
    <dbReference type="EnsemblBacteria" id="AFZ52652">
        <property type="protein sequence ID" value="AFZ52652"/>
        <property type="gene ID" value="Cyan10605_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0510"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.540"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_3"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13666" checksum="CC4CCEAEC9FF1738" modified="2013-03-06" version="1">MTINRKNLVKRRHLRIRKKVQGTPERPRLAVFRSNFHIYAQIIDDVAQHTLVAASTLDKELREKLKDASTSNCDASAEVGKLIAQRALSKGIDKVVFDRGGNLYHGRVKALADAARESGLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q7</accession>
    <name>K9Z1Q7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnS</name>
        <name evidence="7" type="ordered locus">Cyan10605_0136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218025.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0136"/>
    <dbReference type="EnsemblBacteria" id="AFZ52293">
        <property type="protein sequence ID" value="AFZ52293"/>
        <property type="gene ID" value="Cyan10605_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0136"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.140"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_3"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="142"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="461" mass="53005" checksum="803280E9D047B093" modified="2013-03-06" version="1">MARIINILRNGKAQEEIEVKGWIRTKRELKEFSFIEINDGSSLGNLQAVLNSDLLNYQDIIKRLNTGVSVSIKGILVDSPAKGQKVELQAQEVIIFGDCDPETYPLQKKRHSFEFLRTIGHLRGRTNTIGAVMRVRNACANAIHQFFQSKGFLWVHTPIITASDCEGAGELFTVTNLSLEKIIQDKKDEINYENDFFGRQAYLTVSGQLEAEIMAMSFQNVYTFGPTFRAENSNTSRHLAEFWMVEPEIAFCDLEGDQNLAEEFLKYVFKYVLDHCPEDMAFFNQRINQNVLINAENIINNEFARITYTEAINLLEKSKKKFEFPVEWGIDLQSEHERYLAEELFKKPVIVTDYPKEIKAFYMRLNDDQKTVAAMDILAPGIGEIIGGSQREERLDVLQSRIVECNINGDELWWYLDLRRYGTVPHAGFGLGFERLVQFMTGMENIRDVIPFPRTPMNAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R4</accession>
    <name>K9Z1R4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ordered locus">Cyan10605_0375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218251.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0375"/>
    <dbReference type="EnsemblBacteria" id="AFZ52520">
        <property type="protein sequence ID" value="AFZ52520"/>
        <property type="gene ID" value="Cyan10605_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0375"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.395"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_3"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="31652" checksum="E8810B2307E98DB4" modified="2013-03-06" version="1">MNRGHLLTEQINQASVNLDQLSPLEIVDLFNQEDQKTLDAIASSRQEIAQTIEITAQQLGKGGRLFYIGAGTSGRLGVLDAAECPPTFCTPPTMVQGILAGGKEALVKSSEALEDRREDGAKAMIDHNISNLDVVIGITAGGTTPYVHGALQEAKKRGAIAVAMSCVPKEQVSIPADIDIRLLTGAEILAGSTRLKAGTVTKMALNIISTGVMVQLGKVYGNRMIDVSVTNSKLEDRALRIISDLTGLDREKAQNLLSASGSKVKLALLMHWTNTSKAEAETLLARNNGNLRQAINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U5</accession>
    <name>K9Z1U5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218408.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0536"/>
    <dbReference type="EnsemblBacteria" id="AFZ52677">
        <property type="protein sequence ID" value="AFZ52677"/>
        <property type="gene ID" value="Cyan10605_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0536"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_11_5_3"/>
    <dbReference type="OMA" id="HQTYLIE"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="34500" checksum="0D95E1D4B902C15E" modified="2013-03-06" version="1">MTADEILRLYDQGERNFSNSDLSREDIIGANITQIDLNRSNLSWANLSGSDLSGGNLSRADLIHSRFISAKLISVNLSNSNLSYGDLSWTNLNSANLSQADLSYCNLSKSSLINSDFSYANLQNCKLTKANFMGANFTRANLSGADLSGVNLTGADFTRADLSGANLQGCDLEEANLRCADLSKSILRNADLSESILQGVNLENANLRGANFSGAVLKNTNVDYQIKLSELNIKSPHKNKIVFTGANLQEVVLENAIIKNSIFSYACLFKANLTEASFHRASMIDAYLSHGDLRGANLRSSALSGVILTGTTMPDGSIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z6</accession>
    <name>K9Z1Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218900.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1043"/>
    <dbReference type="EnsemblBacteria" id="AFZ53169">
        <property type="protein sequence ID" value="AFZ53169"/>
        <property type="gene ID" value="Cyan10605_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1043"/>
    <dbReference type="eggNOG" id="ENOG50338GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="OMA" id="KNYEFTP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12099" checksum="3DE740C2AC9C8167" modified="2013-03-06" version="1">MSIAAVEAFLDKVQTDEELQKELATALEAENDRQAVTDLANSKNYEFTPDELWAEIQKRQNDALARQQSGELSDEELEAVAGGEFVVGSVLITAASFAASVTAGVAIPNIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z216</accession>
    <name>K9Z216_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218962.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1109"/>
    <dbReference type="EnsemblBacteria" id="AFZ53231">
        <property type="protein sequence ID" value="AFZ53231"/>
        <property type="gene ID" value="Cyan10605_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1109"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1173"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042265_0_0_3"/>
    <dbReference type="OMA" id="EADICTN"/>
    <dbReference type="OrthoDB" id="454779at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="477" mass="56180" checksum="52C0F3912B63A934" modified="2013-03-06" version="1">MRITRNSTVNKFSTFVFFPDENNQFFCWQTDLLLKRNIEKIVAEKKKQSCEKIARSFLSSILNKHDKIKQNHLSAYLQETCLWSARIIYERLYLTLKLLTLEECFSSGNLALIQPEKLLKNYQVKYGTKITTYAQTRLNTIIKDTVYRNRQWKLLSDWGLLTKIGIKRAESILTIQGGLKDNKLQECLLAWQCYLDNYQTCGIRKNKVLSEPNSTHLQLMVQQYNLQIKQLNQTQITPDELKQKLKFCIEMARLATNPITVMYEENDHSLIEANSDNYIDDLAIEKESQEIKNIIINSFQNQESINQAILYFIFSLNLTQGEIITIINQSYPDFIKQQYQLSRKINSIKKSIIDEIIKIKNLPKNQTSAKEIKPLISLLDACIQEYIEDDIFTLIDQCYKNLNSEQQKYLEQQYFKETKNSNKNKNSFNHNNEIIIDNVRKKLANKLNIFIPKISMIDNNINMQIQKFCENYFNRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z232</accession>
    <name>K9Z232_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">RuBisCO chaperone RbcX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbcX</name>
        <name evidence="10" type="ordered locus">Cyan10605_0643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">An RbcL-specific chaperone. The central cleft of the RbcX homodimer (RbcX2) binds the C-terminus of an RbcL monomer, stabilizing the C-terminus and probably preventing its reassociation with chaperonin GroEL-ES. At the same time the peripheral region of RbcX2 binds a second RbcL monomer, bridging the RbcL homodimers in the correct orientation. The RbcX2(2)-bound RbcL dimers then assemble into the RbcL8 core (RbcL8-(RbcX2)8). RbcS binding triggers the release of RbcX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts with the exposed C-terminal peptide of RbcL via its central cleft, contacts a second RbcL monomer via its peripheral polar surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Carboxysome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">Most protein is cytoplasmic, but some is in the carboxysome.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The homodimer has 2 functional domains, a central cleft essential for production of soluble RbcL in which the RbcL peptide binds, and a polar surface which plays a role in correct RbcL subunit arrangement.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RbcX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218513.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0643"/>
    <dbReference type="EnsemblBacteria" id="AFZ52782">
        <property type="protein sequence ID" value="AFZ52782"/>
        <property type="gene ID" value="Cyan10605_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0643"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.679"/>
    <dbReference type="eggNOG" id="ENOG50315SX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129346_0_0_3"/>
    <dbReference type="OMA" id="DYLPEMV"/>
    <dbReference type="OrthoDB" id="1698892at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110102">
        <property type="term" value="P:ribulose bisphosphate carboxylase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00855">
        <property type="entry name" value="RbcX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038052">
        <property type="entry name" value="Chaperonin_RbcX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003435">
        <property type="entry name" value="Chaperonin_RcbX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046381">
        <property type="entry name" value="RbcX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33791">
        <property type="entry name" value="PTHR33791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02341">
        <property type="entry name" value="RbcX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158615">
        <property type="entry name" value="SSF158615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4 8" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5 8" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="3 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="137" mass="15962" checksum="EA64D4C32D55A87C" modified="2013-03-06" version="1">MSYKQIAKDTAKVLQSYLTFQAVKIIINQLTETNPRQAIWLTNYSDRTSVQDSEKYLNNLLGENKELVLRILTVREDLAEQVLEFLPEMVKTNIIQSNIEHRRHLLERLTQTQSLPVNSSDKDENNQESNSLDNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z259</accession>
    <name>K9Z259_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219010.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1159"/>
    <dbReference type="EnsemblBacteria" id="AFZ53281">
        <property type="protein sequence ID" value="AFZ53281"/>
        <property type="gene ID" value="Cyan10605_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1159"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_5_1_3"/>
    <dbReference type="OMA" id="YPCEEGG"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9398" checksum="CD010A60C13B4AD3" modified="2013-03-06" version="1">MKTQDKLTALEDYLNLNYLITFHPENEGGYTVMIQDLEGCISEGETVEEAMKNILSAKQPWLETAWKHGDFIPLPSHFILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F0</accession>
    <name>K9Z2F0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracytoplasmic solute receptor protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">TRAP transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the tripartite ATP-independent periplasmic (TRAP) transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219110.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1265"/>
    <dbReference type="EnsemblBacteria" id="AFZ53381">
        <property type="protein sequence ID" value="AFZ53381"/>
        <property type="gene ID" value="Cyan10605_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1265"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1336"/>
    <dbReference type="eggNOG" id="COG4663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036176_0_1_3"/>
    <dbReference type="OMA" id="FWEGGPT"/>
    <dbReference type="OrthoDB" id="1251304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031317">
        <property type="term" value="C:tripartite ATP-independent periplasmic transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043177">
        <property type="term" value="F:organic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015849">
        <property type="term" value="P:organic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13682">
        <property type="entry name" value="PBP2_TRAP_alpha-ketoacid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026289">
        <property type="entry name" value="SBP_TakP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041722">
        <property type="entry name" value="TakP/all3028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039026">
        <property type="entry name" value="SiaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR039026-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR039026-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="366" mass="40613" checksum="ABA23E7D12C614D3" modified="2013-03-06" version="1" precursor="true">MQRRQFLTNAGISAVTSATLVSCQSQNKSSVTANSLPEIKWRMVTSWPKSLDTIYGSVVGLCDRLKAMSSGKFQITPYAAGEIVPGLEVLDTVQNATVECGHTASYYYVGKNSALAFGTGIPFGLLAGQHNAWWYYGGGLEAMQKVYSDFNIINFPAGNTGAQMGGWFKREVKSLADLKGLKMRIPGLGGEVMGKLGVTVQNIPGGEVFLALDRGAIDAAEWVGPYDDEKLGLNKVAQYYYYPGWWEPGPSLEILINKSAWEKLPTEYQNMMEVCARESNITMLAHYDFVNQQALKSLITGGTKLVPFPQDILKQAEKISFELYENNAQQNPTFKEIYQSWLEFRKGILQWNSINELSFANFVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K8</accession>
    <name>K9Z2K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218344.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0471"/>
    <dbReference type="EnsemblBacteria" id="AFZ52613">
        <property type="protein sequence ID" value="AFZ52613"/>
        <property type="gene ID" value="Cyan10605_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0471"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.499"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="HATLIRI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="423"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="566"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="826" mass="94650" checksum="247AE460912F16D8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M7</accession>
    <name>K9Z2M7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Ycf48-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Unknown. The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the Ycf48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0689"/>
    <dbReference type="EnsemblBacteria" id="AFZ52825">
        <property type="protein sequence ID" value="AFZ52825"/>
        <property type="gene ID" value="Cyan10605_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0689"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.723"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057027_0_0_3"/>
    <dbReference type="OMA" id="EGWIAGQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01348">
        <property type="entry name" value="Ycf48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016705">
        <property type="entry name" value="Ycf48/Hcf136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017875">
        <property type="entry name" value="PSII_HCF136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PSII_BNR" evidence="4">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 2" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 3" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 4" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="37898" checksum="E06F34B7F2E57D1F" modified="2013-03-06" version="1" precursor="true">MKLFLNKLKPFLVSILIGFLCVSCAFLPSLSYNPWQLISLDAESTFADIDFTNDSNHGWLVGTRATLFETKDGGDNWQQKIIDLGEEKVNFTGVSFYDNEGWITGMPSVLLHTNNGGETWERIPLSEKLPGSPYDITALDDQTAEMVTNLGAIYKTTDGGKTWKALVEGAVGVARSITRSADGKYVAVSARGNFYSTWQPGDTEWTPHQRTSSRRLQNMGFLDGGDRLWLIARGGQIQFSKPNNFEEWEEAITPEYATSWGFLDLTVQNQEQIWLAGGSGNLLLSKDNGQSWFKDREIESVPSNLYKIVFVGDNKGFILGERGVLLKYNTQSADVSQSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N5</accession>
    <name>K9Z2N5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerate kinase</fullName>
            <ecNumber evidence="1">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218566.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0699"/>
    <dbReference type="EnsemblBacteria" id="AFZ52835">
        <property type="protein sequence ID" value="AFZ52835"/>
        <property type="gene ID" value="Cyan10605_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0699"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.732"/>
    <dbReference type="eggNOG" id="COG4240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_2_0_3"/>
    <dbReference type="OMA" id="FWRSLHP"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="40698" checksum="F0302547F204DF27" modified="2013-03-06" version="1">MNILSKSELNSIILKIIERQSLSSSEQEILKTFTPHSNYPFTHNQEPDLYREKISILPLIYPSLKKILQQLNFTESENYLTTIWFFWLPLALELANLYRQKSHPIVIGILGSQGTGKTTITKILPLIWQYLNLSSVAISLDDLYKTYQDRKELLKLDSRLIWRGPPGTHDIKLGLDVLTALKNRQYPVNIPRFDKSLHEGRGDRISGEIVNQADIIIFEGWFVGVKPVEEKVFKNPPPPIITKSDRTFAIDCNRRLKEYLPLWEKLNYLMILNPEDYRYSLKWRQEAEQKMIAQGKTGMNNQEIEEFVFYFWKALHPEIFIKPLIENPQSVNLVVNIDIHHQVNQIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R4</accession>
    <name>K9Z2R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219225.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1383"/>
    <dbReference type="EnsemblBacteria" id="AFZ53496">
        <property type="protein sequence ID" value="AFZ53496"/>
        <property type="gene ID" value="Cyan10605_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1383"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080918_0_0_3"/>
    <dbReference type="OMA" id="WEAMISE"/>
    <dbReference type="OrthoDB" id="1693660at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="32913" checksum="D0413007DAC3A414" modified="2013-03-06" version="1">MATEEINALIEQVDERAQALILEGEKSFTQVEEIVTKATEIAENLSQAGEEAQAKWEAMISELEEAENTLETELENTKGIMGEFDGKTNEVNQQITQLMTDFQTRLQDLLARKQEITEEIDSQTEENKSGFEQYSQNIQQTEEQMGSYQETVKGNIEEFNGAVDTATESFQTQKENILQQFSDLAEELSNKLESLQSEFEDVAEQSKSGAENLTQNLESQAGDLISNLTSKFTEELMGDLTESAGGLTDALGFLKDAGEESGELLDGGIGDIVDKVDEVTDLIEDIKPVLDAIQTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W4</accession>
    <name>K9Z2W4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">Cyan10605_1440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219280.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1440"/>
    <dbReference type="EnsemblBacteria" id="AFZ53551">
        <property type="protein sequence ID" value="AFZ53551"/>
        <property type="gene ID" value="Cyan10605_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1440"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_3_3"/>
    <dbReference type="OMA" id="TWMLETH"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="127" mass="14425" checksum="8020E27A73FD2F3C" modified="2013-03-06" version="1">MKETYFFIALGAILGALSRYYLTLFCLNKWGNKYSYGTLFANLSGSFLIGFISTIIFYKIISLELQQFILIGFLGAYTTFSSYILDTSNLYREKRFMDAIFYGIGTPLIGFICIELGIISAKIYNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W9</accession>
    <name>K9Z2W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC exporter ATP-binding subunit, DevA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218424.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0552"/>
    <dbReference type="EnsemblBacteria" id="AFZ52693">
        <property type="protein sequence ID" value="AFZ52693"/>
        <property type="gene ID" value="Cyan10605_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0552"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.582"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="LPWLTCF"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014324">
        <property type="entry name" value="ABC_heterocyst_DevA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02982">
        <property type="entry name" value="heterocyst_DevA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="27146" checksum="A0117DD7449A95AD" modified="2013-03-06" version="1">MITITENTNNNPENLDNNKVVEIKNLDFYFGHGSIRKQILFNINLTLKKGEVVILKGPSGSGKTTLLTLMGALRSASYGSLKVFNQELINAPEKLLINIRKNIGYIFQAHNLLNSLTARQNVQMSLELHSQFSHEEVKQKSIEMLNAVGLGDRINYYPENLSGGQKQRVAIARALVSHPKMVLADEPTAALDSKSGRDVVDIMQKLARQQGCTILIVSHDDRILDVADRIIELEDGKLLTESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X1</accession>
    <name>K9Z2X1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein Cyan10605_1391</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219233.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53504">
        <property type="protein sequence ID" value="AFZ53504"/>
        <property type="gene ID" value="Cyan10605_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1391"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1469"/>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165326_0_0_3"/>
    <dbReference type="OMA" id="RDRNMLI"/>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9102" checksum="B5CAC489234C38BF" modified="2013-03-06" version="1">MDIQLINIGFGNIVAANRVIAIVSPESAPIKRIINEAKDKGQLIDATYGRRTRAVIITDSNHVVLSAIQPETVAHRFVSHVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z0</accession>
    <name>K9Z2Z0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218823.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0962"/>
    <dbReference type="EnsemblBacteria" id="AFZ53092">
        <property type="protein sequence ID" value="AFZ53092"/>
        <property type="gene ID" value="Cyan10605_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0962"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1015"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_4_3"/>
    <dbReference type="OMA" id="DYAVFGY"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="30211" checksum="47B8DB13575997E6" modified="2013-03-06" version="1" precursor="true">MKVSSFNKNLNLIVVLCLITVIGLSGCQQLNATSGVDNNTQETATSAVDNSNSEDNLPSGETNSNGKESNNQDNISLNNNSMNLPRLEGNATVVMKINGQSVTIELDGNNAPITAGNFVDLVQQGVYNGSMFHRVIKEPQPFVAQGGDPQSKDPSLPVTALGTGSYVDPTTKTSRYIPLEIRPEYDETKEGVTPPEIIYGQTITTAPELKHDYGVIAMARSQMPDSASAQFYFTLAELPFLDGNYAVFGRVTEGMDVVTNINQGDRIESAEVISGAENLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z316</accession>
    <name>K9Z316_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219330.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1490"/>
    <dbReference type="EnsemblBacteria" id="AFZ53601">
        <property type="protein sequence ID" value="AFZ53601"/>
        <property type="gene ID" value="Cyan10605_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1490"/>
    <dbReference type="eggNOG" id="ENOG5030JQG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127001_0_0_3"/>
    <dbReference type="OMA" id="SEINWPR"/>
    <dbReference type="OrthoDB" id="1727434at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="18927" checksum="6D12D873F108FBC7" modified="2013-03-06" version="1">MQEKIKKELKKVGSLTLFFLIGFAYILITMKFLLAEYDIDVYVFSKTIISALVAAKVVAIMDAMPFINLYSNSPGYIRVMYKSLIYVGGVFIISLVEDLFHTYRQVNSIQGAISIFIETRHFFHFMAVTMSISLVFIIHNIFYEIDSYLGKGKLAKLFFEKPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z321</accession>
    <name>K9Z321_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219335.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1495"/>
    <dbReference type="EnsemblBacteria" id="AFZ53606">
        <property type="protein sequence ID" value="AFZ53606"/>
        <property type="gene ID" value="Cyan10605_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1495"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1587"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_5_0_3"/>
    <dbReference type="OMA" id="GPYAHTH"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8759" checksum="5AA25057613C52FA" modified="2013-03-06" version="1">MNKFDYTITIQWSDEDNCFVVFFPEFSQNVMQPFTHGETYEEALKNGQEVLELIIEEYQEDGKILPQPKTFVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z352</accession>
    <name>K9Z352_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Phycocyanobilin:ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="3 6">1.3.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pcyA</name>
        <name evidence="7" type="ordered locus">Cyan10605_0885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:15309"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57437"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="EC" id="1.3.7.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the HY2 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.5" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218746.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z352"/>
    <dbReference type="STRING" id="755178.Cyan10605_0885"/>
    <dbReference type="EnsemblBacteria" id="AFZ53015">
        <property type="protein sequence ID" value="AFZ53015"/>
        <property type="gene ID" value="Cyan10605_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0885"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.930"/>
    <dbReference type="eggNOG" id="ENOG502Z7RN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074224_0_0_3"/>
    <dbReference type="OMA" id="YQTPQFR"/>
    <dbReference type="OrthoDB" id="1105902at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050620">
        <property type="term" value="F:phycocyanobilin:ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010024">
        <property type="term" value="P:phytochromobilin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00618">
        <property type="entry name" value="Ferredoxin_bilin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009249">
        <property type="entry name" value="Ferredoxin-dep_bilin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022870">
        <property type="entry name" value="Ferredoxin_bilin_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34557">
        <property type="entry name" value="PTHR34557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05996">
        <property type="entry name" value="Fe_bilin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="28157" checksum="76A484F66C122894" modified="2013-03-06" version="1">MVNISSDLKDRLHPLINQLAETIITTWQENLSLSPYQLPEGLGYVEGKLEGERLTIENRCYQTTQFRKMHLELAKVGTNLDILHCVMFPHVNYPLPMFGCDIVAGKAGISAAIVDLSPTNAEKNLAEDYNNALSALENSQFSDVRDLPVWGDIFSPFCLFIRPANEEEEIQFLNRVRDFLTIHCQIAEKSQSVSDEEKLIYWEGQKNYCSQQQQNDKTRRVLEKAFGEEWAENYMTSVLFDLPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A5</accession>
    <name>K9Z3A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218928.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53197">
        <property type="protein sequence ID" value="AFZ53197"/>
        <property type="gene ID" value="Cyan10605_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1073"/>
    <dbReference type="HOGENOM" id="CLU_1233357_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="224" mass="25968" checksum="D2D76691D2F9C85B" modified="2013-03-06" version="1">MKFHLSSIIQIFFVRFNRLFRSHKIEAFEAIMILAISHAYGYFNPKQLADFLGVNHQKIYAEISSWTLYKLQKVLKLLMVNVAVEQLQIIEKKSNSTQSRVKITLAVDDSVIDRVGKRLRCTFTWYSGRWKKVVNGQNILGIILTINGKAIPIGLKYCSKQGRKNTHKPSILIAMLKEIKEECLKENINISKYPITLDSWDVSKQLKEQLDELGFTKIILIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C4</accession>
    <name>K9Z3C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218609.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0745"/>
    <dbReference type="EnsemblBacteria" id="AFZ52878">
        <property type="protein sequence ID" value="AFZ52878"/>
        <property type="gene ID" value="Cyan10605_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0745"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.782"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050371_0_0_3"/>
    <dbReference type="OMA" id="HYLNWSD"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="223"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="447" mass="50593" checksum="2D347C2F7F75C954" modified="2013-03-06" version="1">MSNFENKYWELSFNSVSEKLFNNLKEGEYLIIQLTAEKSHFIRFNHAKVRQTGMVIDAEVSLKLISSQKTAYANFPLTGNEEIDLSLALENLDYLRSEIKLLPEDPYIVLPQYHTSSHEVYPSNLLNPKIAIESILKPVQGLDFTGYYAGGLIIRANYNSLGQKHWFATDSFFIDYSLINHNNKAIKGTFSARDWDLNQYQHQINWNKKQLEKLNLPIHEVKPGNYRTYLAPSAIASLLGMFSWGAISEASLQQGGSALAKMRQEENLSVLFSLKENFESGNVPRFNDLGEVSPNELPLIESGKLVNTLINSRTALEYNLTANGANNSESLRSPEIKAGSLKEEEILKNLDTGLYLSNLHYLNWSDRSSGRITGMTRYGCFWVEKGEIVATIKDLRFDDSLYSFFGHNLIALTDFREFIPEVSTYETRSLGGCLVPGALVNQFTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H5</accession>
    <name>K9Z3H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219016.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1165"/>
    <dbReference type="REBASE" id="58407">
        <property type="entry name" value="Cap10605ORF1163P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53287">
        <property type="protein sequence ID" value="AFZ53287"/>
        <property type="gene ID" value="Cyan10605_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1165"/>
    <dbReference type="eggNOG" id="ENOG5032KKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2507109_0_0_3"/>
    <dbReference type="OrthoDB" id="2162008at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="10152" checksum="6F5516D06B6834D5" modified="2013-03-06" version="1">MKIESLNKKELENYCHKYGIKIQSNNTKKQLLELINKDKFNKITNAIKQGKQLELLISQIRLISEEYAYQLKMQIDLRVDINRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K1</accession>
    <name>K9Z3K1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219046.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1198"/>
    <dbReference type="EnsemblBacteria" id="AFZ53317">
        <property type="protein sequence ID" value="AFZ53317"/>
        <property type="gene ID" value="Cyan10605_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1198"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1264"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342460_0_0_3"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="327"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="476"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="792" mass="90039" checksum="171CD8142BF1C5A8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L1</accession>
    <name>K9Z3L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NnrU protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0836"/>
    <dbReference type="EnsemblBacteria" id="AFZ52968">
        <property type="protein sequence ID" value="AFZ52968"/>
        <property type="gene ID" value="Cyan10605_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0836"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.879"/>
    <dbReference type="eggNOG" id="COG4094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080297_0_0_3"/>
    <dbReference type="OMA" id="FFNHRYD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009915">
        <property type="entry name" value="NnrU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07298">
        <property type="entry name" value="NnrU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="NnrU" evidence="2">
        <location>
            <begin position="39"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="30990" checksum="EA9E4857AC400D4C" modified="2013-03-06" version="1">MLHFFSEKMFFFAYESIYRCFFAQFNLKLPLWMNDSHFIMIALLFTFAIAHSGLAALRMWAERKIGARLYRVFFALVSIPLATVLIIYFFNHRYDGLVLWQLQDISGIKETVWILSFISFIFLYPATFNLLEIAAVAKPEVHLYETGIIRISRHPQMVGQVIWCIAHTIWLGTTFTLVTSFGLIAHHLFAVWHGDYRLTKRYGEAFIKVKERTSIIPFLAIIDGRQKLEIKEFLRPAYVGVTGFVFLFWWLHPWLMTATSRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V9</accession>
    <name>K9Z3V9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b6-f complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome b6-f complex subunit PetM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Cytochrome b6-f complex subunit VII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">petM</name>
        <name evidence="9" type="ordered locus">Cyan10605_1784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PetM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219613.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1784"/>
    <dbReference type="EnsemblBacteria" id="AFZ53886">
        <property type="protein sequence ID" value="AFZ53886"/>
        <property type="gene ID" value="Cyan10605_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1784"/>
    <dbReference type="HOGENOM" id="CLU_216743_0_0_3"/>
    <dbReference type="OrthoDB" id="2088217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009512">
        <property type="term" value="C:cytochrome b6f complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00396">
        <property type="entry name" value="Cytb6_f_PetM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012595">
        <property type="entry name" value="PetM_cyt_b6/f_cplx_su7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08041">
        <property type="entry name" value="PetM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="36" mass="3888" checksum="B8FBFD1C939570FC" modified="2013-03-06" version="1">MTAESMLFNGAILCFVVVLIGLAWGFLLLKLTGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z416</accession>
    <name>K9Z416_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219216.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1374"/>
    <dbReference type="EnsemblBacteria" id="AFZ53487">
        <property type="protein sequence ID" value="AFZ53487"/>
        <property type="gene ID" value="Cyan10605_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1374"/>
    <dbReference type="eggNOG" id="ENOG5032ZI7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177665_1_0_3"/>
    <dbReference type="OMA" id="DVMTIAM"/>
    <dbReference type="OrthoDB" id="1933357at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8238" checksum="7A994FA0F19A013B" modified="2013-03-06" version="1">MITVKGEIQYRAIASGTWVLVSDTGETYELYKPSENLRQEGLKVEIKGNIRSDVMTIAMVGQILEVKEFSICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z424</accession>
    <name>K9Z424_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1844"/>
    <dbReference type="EnsemblBacteria" id="AFZ53946">
        <property type="protein sequence ID" value="AFZ53946"/>
        <property type="gene ID" value="Cyan10605_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1844"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1957"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_2_2_3"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22143" checksum="3290F2DD59203DDA" modified="2013-03-06" version="1">MIHDQPQEVNSLVSIMTKNYQEISTSSGYQNAFPNETLSVIALGSNLGDSQKILNEAIFTLKETEKIQLINHSHWYQTKPVGPPQPDYLNGCAIINTTLSPHQLLNTLLEIEKKFGRERKEKWGARTLDLDLIFYGDLILNTSTLEIPHPRMRERTFVLEPLAEIAPHWIDPVTGLRVSELLINISENKTLNLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A0</accession>
    <name>K9Z4A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219696.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1869"/>
    <dbReference type="EnsemblBacteria" id="AFZ53969">
        <property type="protein sequence ID" value="AFZ53969"/>
        <property type="gene ID" value="Cyan10605_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1869"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1984"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006955_0_0_3"/>
    <dbReference type="OMA" id="HEATEIF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="264"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="719"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139521" checksum="DEB8520605179B5A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B5</accession>
    <name>K9Z4B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218934.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1080"/>
    <dbReference type="EnsemblBacteria" id="AFZ53203">
        <property type="protein sequence ID" value="AFZ53203"/>
        <property type="gene ID" value="Cyan10605_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1080"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1143"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_1_3"/>
    <dbReference type="OMA" id="CPVVSCS"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="381" mass="44322" checksum="BAF42CCE32B14107" modified="2013-03-06" version="1">MGVKFKNNKLRVLHVIAALERGGAERQLQIIVNNADRSVYKMGILFISYGSEIPNIRDDIDLLQIKDYYKINLFRHWDSIRQSIVSWQPDILHLWLPEIMTIPSAIVGKLYSIPILSAQRRSINNSGSMYQWIRDRSRYIQHVLADRLVTNFDTINEPLFYRILFHRKKGITIPNSIELKLTSSNLVFPDLLDEQKIFKLWFTGRFVKQKCLPLLIEAIGILKKENYPVVLFVCGHGSERETLILKKLVEKHKLEDSIIFLGYRKDWHILVKKADLLVLPSIREGMPNVMLEAMALGIPVLVSDISEIKALVEHKKNAYLFHVNRLDSLVNSLKELYSLGELRKYIAQNGQEFVQQLVNHRNMVSSYENLYQELLMSKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C2</accession>
    <name>K9Z4C2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219321.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1481"/>
    <dbReference type="EnsemblBacteria" id="AFZ53592">
        <property type="protein sequence ID" value="AFZ53592"/>
        <property type="gene ID" value="Cyan10605_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1481"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1573"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_2_3"/>
    <dbReference type="OMA" id="DNPFKSH"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22705" checksum="769281798C6F093C" modified="2013-03-06" version="1">MEIAIFGTSADPPTISHQKILVYLANHYDLVSVYASDNPFKSHASGFVHRQKMLDLLVRDLHRDYPHLHHTPEVSDRRSIHTLEKAKQRWGEDNNFTIVIGSDLVDQIFQWYQAEKLLSQVKILVIPRENYPLTQEDIEKINRHSNSGAFTKWHFAIASCHIPPYSSSNYRENHHDSTVIKSIQEYIEKNHLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E0</accession>
    <name>K9Z4E0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219336.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1496"/>
    <dbReference type="EnsemblBacteria" id="AFZ53607">
        <property type="protein sequence ID" value="AFZ53607"/>
        <property type="gene ID" value="Cyan10605_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1496"/>
    <dbReference type="eggNOG" id="ENOG5032YQV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184328_0_0_3"/>
    <dbReference type="OMA" id="NAVVNTW"/>
    <dbReference type="OrthoDB" id="1997676at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8784" checksum="25C2F709E137CFF4" modified="2013-03-06" version="1">MKAEELDLLFEEGKEDILEYFDLSTAKRPALEKTKIDLDLPQWMIIALDKEAKRLGIESQSLIKVWIAQHLDSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E8</accession>
    <name>K9Z4E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor 2 (EF-2/EF-G)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219739.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1916"/>
    <dbReference type="EnsemblBacteria" id="AFZ54014">
        <property type="protein sequence ID" value="AFZ54014"/>
        <property type="gene ID" value="Cyan10605_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1916"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2033"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_2_3"/>
    <dbReference type="OMA" id="FKFLDDW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III"/>
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    </dbReference>
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        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00889">
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    </dbReference>
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        <property type="entry name" value="SSF50447"/>
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        <property type="entry name" value="SSF52540"/>
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        <property type="entry name" value="SSF54980"/>
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    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="672" mass="75039" checksum="CD20639589A0BC59" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H9</accession>
    <name>K9Z4H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219369.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1533"/>
    <dbReference type="EnsemblBacteria" id="AFZ53642">
        <property type="protein sequence ID" value="AFZ53642"/>
        <property type="gene ID" value="Cyan10605_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1533"/>
    <dbReference type="HOGENOM" id="CLU_198120_1_0_3"/>
    <dbReference type="OMA" id="NIYSDNA"/>
    <dbReference type="OrthoDB" id="2083148at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="7315" checksum="3F0D7F39FBD45406" modified="2013-03-06" version="1" precursor="true">MQFIRQQIIPFITIAIALFALVAVTARSFIATDLAEPAPIETITGSSESSPSALTLPSVVNGVRSSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N7</accession>
    <name>K9Z4N7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219871.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2057"/>
    <dbReference type="EnsemblBacteria" id="AFZ54146">
        <property type="protein sequence ID" value="AFZ54146"/>
        <property type="gene ID" value="Cyan10605_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2057"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2186"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_0_3"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22887" checksum="B8A8EF4461D9347B" modified="2013-03-06" version="1">MAYQLPNLPYEYNALEPYISKSTLEFHHDKHHAAYVNKFNDAVAGTELDNQPIETIIKKFAEDTSKQGIFNNAAQAWNHSFYWQCMKPNGGGNPTGVLADKINTDFGSFEKFIEAFKNAGATQFGSGWAWLVLDGDTLKVTKTPNADNPFTKNQIPLLTMDVWEHAYYLDYQNRRPDYINDFIEKLVNWDFVAQNFSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T2</accession>
    <name>K9Z4T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219147.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53418">
        <property type="protein sequence ID" value="AFZ53418"/>
        <property type="gene ID" value="Cyan10605_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1303"/>
    <dbReference type="eggNOG" id="ENOG5034308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962137_0_0_3"/>
    <dbReference type="OMA" id="AQTHQAT"/>
    <dbReference type="OrthoDB" id="1877255at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="32742" checksum="933CA93BA9A935A1" modified="2013-03-06" version="1">MARRKTKATTGLSNPKSKVNLTITPEAKSALDVITKEMGLTRSALFEGLLNGSISLSSQNSEKNIDISFNEDKSDGETISQINILEGENVDNQEEKMDSISEDLEDYKHKISVLEKEIKAQEEKNNSLEQELVKKSSEIQSLGEQVKNLSTVEKAENNHNFEAKVTELKKIIDEKNSAIASLEEKISHLEQEVKQSKESDDLSVQQDLVEQLKSQIESKNRQIHDLEQAKNNAISSTRNSYDRGIQNHLTLTNEKQKTIIEHLEKRIAELESFASIGEQFLNKWRSKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U9</accession>
    <name>K9Z4U9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ordered locus">Cyan10605_2097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219911.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2097"/>
    <dbReference type="EnsemblBacteria" id="AFZ54186">
        <property type="protein sequence ID" value="AFZ54186"/>
        <property type="gene ID" value="Cyan10605_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2097"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2229"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_3"/>
    <dbReference type="OMA" id="EINDANA"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="25101" checksum="C8F2D7F85D670A13" modified="2013-03-06" version="1">MKISLADLRKNYTQGGLTEEEIYQNPFEQFRHWFEQALESQILEPNAMTLATVNEAGKPTARIVLLKNLDEKGFVFFTNYESKKGQNIAVNPFGCLVFLWGELERQVRVEGKIEKITPEESDQYFHSRPIGSQLGAHISPQSQIIPNREYLDNRLQEVTQQYQNQTIPRPSHWGGYRLVPDAIEFWQGRENRLHDRLEYRLNDNKQWQIVRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X4</accession>
    <name>K9Z4X4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_1684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53787">
        <property type="protein sequence ID" value="AFZ53787"/>
        <property type="gene ID" value="Cyan10605_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1684"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1787"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="DYTGGRM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="34586" checksum="650AB0AB3863A2C4" modified="2013-03-06" version="1">MLKVIKIRIYPDSSQKLALAKAFGSCRWLWNHFLNLMNETYKQTGKGLSGYDVKKLIPELKKQEETSWLSETYSQCLQQVCLNLGVAFNNFFEKRAKYPNFKSKHGKQSLQYPSNVSIKGDCLNVPKIGLVYAKIHRPIDGKIKTVTITKNCCNQYYASVLVDDGKDKPKVSSEGKAIGIDLGLNHFAITSDGSKFDNPKILKKHEVNLKRKQQQLSRKQKGSNNRNKARLKVAKVHKKITNCREDFLHKLSRRIVNENQVIVLEDLNVKGMIKNHCLAKAIQQVGWGQFCTMLKYKAEQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z554</accession>
    <name>K9Z554_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nickel-type superoxide dismutase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220036.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2225"/>
    <dbReference type="EnsemblBacteria" id="AFZ54311">
        <property type="protein sequence ID" value="AFZ54311"/>
        <property type="gene ID" value="Cyan10605_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2225"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_11_1_3"/>
    <dbReference type="OMA" id="GWIEPEL"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="13551" checksum="5D1D67DFDE99AC69" modified="2013-03-06" version="1">MQSEIPHCSFIDFLLLVTRRRRRFRVTGLSMLPLLSPEEEIIIDPYYYRNISPQVNDIVIVEHPLQSQLKIVKRINQIIGDKYFIIGDNQHFSTDSRHFGLISQSLIVGKVIARFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z573</accession>
    <name>K9Z573_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220056.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2245"/>
    <dbReference type="EnsemblBacteria" id="AFZ54331">
        <property type="protein sequence ID" value="AFZ54331"/>
        <property type="gene ID" value="Cyan10605_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2245"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2386"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_3"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33794" checksum="3668A5C8C57872C0" modified="2013-03-06" version="1">MKQFLESEIISTYEEAKIVILPIPYEITTTYRKGCEYGPDAVLTASDQLECYDEELGMETCFHAPIFTHDYIADTRINKNLTADDMLKVTTETVTKLIKDNKFVIAVGGEHAITTGVVQAYQQTLDEPFTVIQIDAHGDMRHEFEGSIHNHACVMRRILELDLPTLPVGIRAICQEEADLIKEKNIPVMWARNIYFNPHWMAEAISNIKTKKVFITIDLDGIDPSLMPGVGTPEPGGMDWYQLLAFMNLIFSSFDVIGCDVMELAPTKDSVVSEFTAAKLIYKLIGYWQQNNSKVRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C5</accession>
    <name>K9Z5C5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220110.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2302"/>
    <dbReference type="EnsemblBacteria" id="AFZ54386">
        <property type="protein sequence ID" value="AFZ54386"/>
        <property type="gene ID" value="Cyan10605_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2302"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_2_3"/>
    <dbReference type="OMA" id="CNIDKQA"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21536" checksum="BC2AA9C95E97A611" modified="2013-03-06" version="1">MEEKAEKILQGALSQFLSYGYAGTTMDKIAKSSGVSKQTLYSHFGDKEGLFYALVSDMASRKFKLVWEKPLEGKPQLVLKNLAETIIKEVSDPLYLDFIHLIVTEVKNYPEVAQLCFKNLAKPAINQLTNYLQNSPDLTLDDPEAIAHIFVNSILHYVLTQEKLQAKKVIPLEQERLINNLITLIVTPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G7</accession>
    <name>K9Z5G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220155.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2347"/>
    <dbReference type="EnsemblBacteria" id="AFZ54431">
        <property type="protein sequence ID" value="AFZ54431"/>
        <property type="gene ID" value="Cyan10605_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2347"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2491"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101369_0_0_3"/>
    <dbReference type="OMA" id="VICIAAY"/>
    <dbReference type="OrthoDB" id="1786010at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025478">
        <property type="entry name" value="COP23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14218">
        <property type="entry name" value="COP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939121" evidence="1">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="23484" checksum="470AC12C6E24781B" modified="2013-03-06" version="1" precursor="true">MKKSSFFSSIVTSVALVSCLSPNTLAQSKNTYSCINYKGKPTTVVDTSRGKIQLIVWESDYFQNSGWTPNKRCQEVTQRFQEFSDKGILKYVTTGQINSYPVICVGTQVPGGGYQCQKDGLLITLQKNDNPNKVLENLFTNAAKVGGTPVTREPTGKYIFPMSNFIKNAPIMTETDIADIKVEETEVTTEVTSESKAIKSEPPLIECSPLLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M8</accession>
    <name>K9Z5M8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220220.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2414"/>
    <dbReference type="EnsemblBacteria" id="AFZ54496">
        <property type="protein sequence ID" value="AFZ54496"/>
        <property type="gene ID" value="Cyan10605_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2414"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2558"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_2_3"/>
    <dbReference type="OMA" id="GRAMGFC"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="311" mass="34653" checksum="16CA79730AAB4F86" modified="2013-03-06" version="1">MITIIYSEEFLNHKTGRLHPESPDRLINICQTLKESQQLKNQLNWIHPTPVEKSLALNWVEKIHDWHHIERIKLIAKRGGGKLDPDTSVSANSYYVGLLAVSAWLDGIEQIVNHHQPCFILARPPGHHATASEGMGFCLFSNAAIAASYAISKKGINRVAILDWDVHHGNGTQAIVESNPNIAYCSLHQSPCYPGTGMAEEKGLYNNVLNIPVKAGSGIAEYEVYFQKQVIPFLKEFQPDILIVSAGYDANFDDPLANMCLFPQDYGKLTKYCLEVTDKIVLGLEGGYHLQALAKSVEYTLLEVLEKTNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N7</accession>
    <name>K9Z5N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1-Cys peroxiredoxin</fullName>
            <ecNumber evidence="8">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219612.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1783"/>
    <dbReference type="EnsemblBacteria" id="AFZ53885">
        <property type="protein sequence ID" value="AFZ53885"/>
        <property type="gene ID" value="Cyan10605_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1783"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1892"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_3"/>
    <dbReference type="OMA" id="MIDYQDT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="23593" checksum="DF610DC004617FF3" modified="2013-03-06" version="1">MTLQLGDQVPDFTQASSQGEISFYDWAGDSWVVLFSHPADYTPVCTTELGTVASLKSEFDKRNVKILALSVDGVESHQGWIQDINETQNTQVNYPILADEDRKVADLYGMIHPNSLNNLTVRSVFIIDPNKKLRLTITYPASTGRNFDEILRVIDSLQLTDNHQVATPANWQDGGDCVVVPSIPTEEAKQKFPKGVTEIKPYLRMTPQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P9</accession>
    <name>K9Z5P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219420.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1584"/>
    <dbReference type="EnsemblBacteria" id="AFZ53693">
        <property type="protein sequence ID" value="AFZ53693"/>
        <property type="gene ID" value="Cyan10605_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1584"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1682"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_3"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="21263" checksum="C113095143184B36" modified="2013-03-06" version="1">MKKLVVATSNAGKLKEMEKHLSDFGVELALKPPEFDVEETGVTFGENARLKASQTAKTLGEWSIADDSGLEVMALNGQPGIYSARYGKTDQERIARLLRELAPFEDRSAQFVCAIAVSNPQGEIVIETEGVCLGQILTEIQGEGGFGYDPVFYVPEVGQTFAQMPSELKQKLSHRGKAFANLQPLLKSLIESEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V0</accession>
    <name>K9Z5V0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ordered locus">Cyan10605_1848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219677.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1848"/>
    <dbReference type="EnsemblBacteria" id="AFZ53950">
        <property type="protein sequence ID" value="AFZ53950"/>
        <property type="gene ID" value="Cyan10605_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1848"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1961"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_3"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="112"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="358" mass="40585" checksum="7D425316C0F0EBFC" modified="2013-03-06" version="1">MTVQIKLNERHHKVLQATIKHYIATAEPVGSKTLMKEYDFSVSSATIRNAMGKLEKAGFLYQPYTSAGRIPSDSGYRVYVDQLLTEQNTVKVSLDPFLDATWLNLSGRYEILFQKITKILAEVSGCIALITLPQVSGNIIHHLQLVRVADNKIMLVIVIDNYQTESFVLDSKELTFNSQKLHPEVLDSELEILSNFLNHKLKGKSLREINHLDGSELDNDFKLYTDFINHLLTKIKSSYHLAQSTPILLQGFSQLVQQPEFSSIDQVKILLNFLETEQKQLLPLLFNINENLDGKRVKIHIGSENPLESMRSCSLISAYYFQEDYPVGSVGIIGPTRMPYEQAIALVECTANYLSEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z623</accession>
    <name>K9Z623_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1740"/>
    <dbReference type="EnsemblBacteria" id="AFZ53843">
        <property type="protein sequence ID" value="AFZ53843"/>
        <property type="gene ID" value="Cyan10605_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1740"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1847"/>
    <dbReference type="eggNOG" id="ENOG502ZWGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126986_0_0_3"/>
    <dbReference type="OMA" id="TGPFQTY"/>
    <dbReference type="OrthoDB" id="1783021at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023983">
        <property type="entry name" value="DNA_S_mod_dnd_assoc_4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04062">
        <property type="entry name" value="dnd_assoc_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17584" checksum="0C85DE658A4687B6" modified="2013-03-06" version="1">MSNRVRISQDKADLVQNLVISPDNPQGVFSTYADLMAFAAALGKRYNFSVTLGAIAKEPSPISIEVFNSRGYESLFKLLGITSTHNLNIISSYEENQEEARIKIFEEYANGGLDRLQQQLKGAVDYSERILLILTQEKECLSNGENKNFDLRKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z639</accession>
    <name>K9Z639_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2093"/>
    <dbReference type="EnsemblBacteria" id="AFZ54182">
        <property type="protein sequence ID" value="AFZ54182"/>
        <property type="gene ID" value="Cyan10605_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2093"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2224"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_1_3"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="315" mass="35599" checksum="3C31F8B77775C07A" modified="2013-03-06" version="1">MLKIITYNSAVAIEQNSLQNIHRAIALGNFDGVHLGHQEVIKPILKDNMAKNLVPALVTFIPHPQEFFSGQTKKLLTPIKEKAQILDKLGIQELILLPFDRELANLTPLEFVKEVLLEKIKANFVSVGEDFCFGYKRQGKAKDLQSLANQYQIEVNITPEQHFLVNQQNIRISSSYIRQSLSEGKVELAKDMLGRNYQIQGKVVEGQKLGRELGFPTANLKIPPEKYLPKQGVYGVKVDIPQQKTYDLSAVMNVGKRPTVGGENIIVEVHLLNWQGDLYGQDLVIKLVNFIRPEKKFTSLDELKNQITLDCQLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z640</accession>
    <name>K9Z640_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ordered locus">Cyan10605_2578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220379.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2578"/>
    <dbReference type="EnsemblBacteria" id="AFZ54656">
        <property type="protein sequence ID" value="AFZ54656"/>
        <property type="gene ID" value="Cyan10605_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2578"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2739"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_3"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20559" checksum="7237F9B3C3B71085" modified="2013-03-06" version="1">MISSNDFRPGVSIELDGGVWRVVEFLHVKPGKGSAFVRTKLKNAQTGSVVEKTFRAGETVPQANLDKRTMQHTYKDGDQFVFMDMETFEEARLSEEQVGDKAKYIKEEMEVNVLFWNNTVLEVELPTSVVLEVIETDPGVKGDTATGGSKPAILETGAQIMVPLFISIGEKVKVDTRNDSYLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z676</accession>
    <name>K9Z676_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219805.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1985"/>
    <dbReference type="EnsemblBacteria" id="AFZ54080">
        <property type="protein sequence ID" value="AFZ54080"/>
        <property type="gene ID" value="Cyan10605_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1985"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="RQGGNAY"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13692" checksum="0BEECAA8528886F2" modified="2013-03-06" version="1">MKKILVVDDSKSQQRLVNGLLQTLDVEVELADNGESALKWLTNNGQPDLILMDIVMPDMSGLDVCRHIRKEMNYKTVPIIFVTTKDEDFDKFWALRQGGTAYITKPYSPTDLLNTVKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z699</accession>
    <name>K9Z699_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2621"/>
    <dbReference type="EnsemblBacteria" id="AFZ54696">
        <property type="protein sequence ID" value="AFZ54696"/>
        <property type="gene ID" value="Cyan10605_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2621"/>
    <dbReference type="eggNOG" id="ENOG5033FZJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382122_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="22691" checksum="F9E9A8C62DDA4F5F" modified="2013-03-06" version="1">MAYLDGWKEFCYWIKMNPDAPLPDGVNLSELYRFAARYRLSYSYQGINLQDYPEQSVEAYGCLLGVFLAYSAFEQLYKAVGLTQIRGKHIVEEWAIENESIAEELRKSHRVIDFLHDKVDTNGLKRRIIEFKLGNNHNILILAQSIRHLVAHGVMTVHGGNVNSKTSIGFCNILKENLDNKTQYCFENYVLNPIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E6</accession>
    <name>K9Z6E6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2614"/>
    <dbReference type="EnsemblBacteria" id="AFZ54689">
        <property type="protein sequence ID" value="AFZ54689"/>
        <property type="gene ID" value="Cyan10605_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2614"/>
    <dbReference type="HOGENOM" id="CLU_3060705_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="53" mass="6313" checksum="D23B8EA5FB205F64" modified="2013-03-06" version="1">MNKFILEPTDENLERFKKVKGTAVYWHTADFFRYDSAIEDELSVIFDAYSDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G2</accession>
    <name>K9Z6G2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ordered locus">Cyan10605_1894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219718.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1894"/>
    <dbReference type="EnsemblBacteria" id="AFZ53993">
        <property type="protein sequence ID" value="AFZ53993"/>
        <property type="gene ID" value="Cyan10605_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1894"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2010"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_3"/>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="20055" checksum="4418F8514942BE2C" modified="2013-03-06" version="1">MARQIIEILSADEIRRTLIRLASQIVEEAPDLSQVVLLGIYTRGVPLAYLLANQIEMIEQVKVAVGALDITFFRDDLDQIKTRTPQKTEIPFDLTGKTVILVDDVIYKGRTIRAALNAVTEYGRPEIIKLLVLVDRGHRQVPIHPDFIGKALPTAKEEKVKVYLDAIDGKDAVELIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J9</accession>
    <name>K9Z6J9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pheophorbide a oxygenase</fullName>
            <ecNumber evidence="8">1.14.15.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.15.17" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220477.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z6J9"/>
    <dbReference type="STRING" id="755178.Cyan10605_2680"/>
    <dbReference type="EnsemblBacteria" id="AFZ54754">
        <property type="protein sequence ID" value="AFZ54754"/>
        <property type="gene ID" value="Cyan10605_2680"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2680"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2845"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003927_1_1_3"/>
    <dbReference type="OMA" id="MWHDLTS"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010277">
        <property type="term" value="F:chlorophyllide a oxygenase [overall] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032441">
        <property type="term" value="F:pheophorbide a oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013626">
        <property type="entry name" value="PaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08417">
        <property type="entry name" value="PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="468" mass="54282" checksum="75B9459E0626258D" modified="2013-03-06" version="1">MTIAQHEEKNIKKSLTSLPIGGEDPNKFDYKEVWYPVFFVNDLHKDKPSRFTLLDEDLVIWWDKKDQQWRVFQDMCPHRLAPLSTGRIDEDGLLECPYHGWTFSGKGDCQSIPQQPEGENRHKSPRACVKSYPSAIAHDMLFVYAGKKENAFLTPMPITQPLIENVEKWTILKTFRDIPYDALTLLENVLDSSHVSYTHHGTVGNRSNAAPVELEVKTADRQGFTGFWAEGPRKGKLGSQSTTFIAPNLMWHDLTSKQLGRTMTVVYVTPISKGKCRVFALFPFQFASKIPQFFIKLTPQWYSHLNQNTILEDDQIFLHYQERYLEKLGGSRKFNQAFYLPTKSDLFVSELRKWVVNYNAYLFPEQEFPETPNHDQLIERYYSHTEQCSSCSGALKNIKTIRFSALIITGIVWSLIPLIFFYVEKLPNFIFPLVSIISVINFSLYLYLGKLEKRFYQGEKIPSRNRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q6</accession>
    <name>K9Z6Q6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="7">FBPase class 1</shortName>
            <ecNumber evidence="7">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fbp</name>
        <name evidence="11" type="ordered locus">Cyan10605_2809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220598.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2809"/>
    <dbReference type="EnsemblBacteria" id="AFZ54876">
        <property type="protein sequence ID" value="AFZ54876"/>
        <property type="gene ID" value="Cyan10605_2809"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2809"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2986"/>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_2_2_3"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="945770at2"/>
    <dbReference type="UniPathway" id="UPA00116"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="6 7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="10">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="37945" checksum="BC7E06581A0536D5" modified="2013-03-06" version="1">MNITQKPQLSIPEHSLDRDCTTLSRHILQQLNDFSGDAQDLSAIMNRIALAGKLISRRLSRAGLMANVLGFTGEDNIQGESVKKMDVYANEVFISVFKQSGLVCRLASEEMEKPYYIPENCPIGRYTLLYDPIDGSSNVDINLNVGSIFAIRQQEGDDLDGEARDLLQNGHKQVAAGYILYGPATVLVYTIGKGVHSFFLDPSLGEFILAEENIKIPNHGSVYSVNEGNFCKWDDSLRDYVRYVHRHDSYTGRYSGALVGDIHRILMQGGVFLYPGTKDKPEGKLRLLYETAPLAFIIEQAGGKASTGKEDILDVIPQKIHQRTPAILGSCEDVDLVKSFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W1</accession>
    <name>K9Z6W1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="ordered locus">Cyan10605_2812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220601.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2812"/>
    <dbReference type="MEROPS" id="M41.024"/>
    <dbReference type="EnsemblBacteria" id="AFZ54879">
        <property type="protein sequence ID" value="AFZ54879"/>
        <property type="gene ID" value="Cyan10605_2812"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2812"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2989"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_3"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="615" mass="67219" checksum="0CD49844BA89E520" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z707</accession>
    <name>K9Z707_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220646.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2858"/>
    <dbReference type="EnsemblBacteria" id="AFZ54924">
        <property type="protein sequence ID" value="AFZ54924"/>
        <property type="gene ID" value="Cyan10605_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2858"/>
    <dbReference type="eggNOG" id="ENOG5032SRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400461_0_0_3"/>
    <dbReference type="OMA" id="IMFSING"/>
    <dbReference type="OrthoDB" id="1930662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938639" evidence="1">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="22359" checksum="27A838B095DA81D9" modified="2013-03-06" version="1" precursor="true">MNRSITQTVLSLIAVLTLNFPAMAKVQPSPINQDSSVPWSKVTEDSFEGKIVYDKDFGGFGESYAIVSSWSKQAIRLSYFWQIKEVDYYKQVKRTRSVWRNNKYEEEVYWDREPVYKYSWKSKNPEYIMFSINGQLYEYQGGKISDDLMSALANAPSTNLKIRLVWSDGSTTDATIGSGTVNAWKTIYQMDSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z759</accession>
    <name>K9Z759_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220300.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2496"/>
    <dbReference type="EnsemblBacteria" id="AFZ54577">
        <property type="protein sequence ID" value="AFZ54577"/>
        <property type="gene ID" value="Cyan10605_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2496"/>
    <dbReference type="eggNOG" id="ENOG5030B6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551833_0_0_3"/>
    <dbReference type="OMA" id="YILFPAY"/>
    <dbReference type="OrthoDB" id="318749at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="546" mass="64377" checksum="D65353C6392F4113" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G1</accession>
    <name>K9Z7G1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220043.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2232"/>
    <dbReference type="EnsemblBacteria" id="AFZ54318">
        <property type="protein sequence ID" value="AFZ54318"/>
        <property type="gene ID" value="Cyan10605_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2232"/>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057487_0_0_3"/>
    <dbReference type="OrthoDB" id="2169737at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13925" checksum="E2A6D34F1AED3F65" modified="2013-03-06" version="1">MTKLVVLNLGAGNLNDGFPHIIARLRANQGTIEQQFVGSLPPAPELENLNHQWQSLYYALHQRFDVAKRRLRLFEVETQEMTNVSVVTFQELCQEDVIYKYQKKLKEIMDNYMINIDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N7</accession>
    <name>K9Z7N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220323.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2519"/>
    <dbReference type="EnsemblBacteria" id="AFZ54600">
        <property type="protein sequence ID" value="AFZ54600"/>
        <property type="gene ID" value="Cyan10605_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2519"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="NDYFVYP"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="176"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="35936" checksum="34477C9A50287052" modified="2013-03-06" version="1">MTDYNPKNFLILAVDDNSVNRILIEKILRKEGYQAKILAHSQEVLPYMEQINPDLILLDLMMPNINGLELCQQIKLNPHFQDIPVIFITASDEKQDLLKAFDLGAVDYITKPFHNRELLARIKTHLELKFTRDELKKALVELEKLATTDELTGISNRRNFSTLAEREFNLAKRQKRYFALLILDIDYFKKINDSHGHIAGDFVIKSVAQQCVLSIRQEDLCARWGGEEFIIFLSESMLEDGIAVARRLRQDIEELSVAFESEQINVTVSIGVAVYNPEDKNVNQTIIRGDMALYQAKNSGRNRVVDENGVCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X5</accession>
    <name>K9Z7X5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220393.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2595"/>
    <dbReference type="EnsemblBacteria" id="AFZ54670">
        <property type="protein sequence ID" value="AFZ54670"/>
        <property type="gene ID" value="Cyan10605_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2595"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2756"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_3"/>
    <dbReference type="OMA" id="EAMHIGF"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="259"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="499" mass="56300" checksum="5A65AB2EA540BB13" modified="2013-03-06" version="1">MNQFNQEFSLLLRACYPLIYIPSQEEERVEKAIASVAQSLGNRHTYIWDFVEGYQDNPNNANFGRRNPLQALEFLEKLPSNTGGVFILRDFHRFLEDISISRKLRNLARSLKAQPKNIVIIAPEVNLPTELREVFTIVEFALPQAEEIKSEIQRLLSATRQNLSEQFLGELVRSAQGLSLERIRRVITRAIAQNGKLEGEDVELILEEKKQSIRQTQILDYYPTKEQISDIGGLDNLKEWLLRRGGAFSESARAYGLPYPRGLLLVGIQGTGKSLTAKAIAHHWHLPLLRLDVGRLFSGLVGESESRTRQMIQIAEALSPCILWIDEIDKGFAGADGKGDSGTTSRVFGTFITWLAEKQSPVFVVATANNIQTLPPEILRKGRFDEVFFVGLPSQAEREAIFTVHLNRLRPHNLQTYDIKRLAYETPEFSGAEIEQTIIEAMHIGFSENRDFTTEDILSAASQIIPLARTAKEQIEFLQNWATSGKARLASRSQSILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z821</accession>
    <name>K9Z821_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221059.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55341">
        <property type="protein sequence ID" value="AFZ55341"/>
        <property type="gene ID" value="Cyan10605_3295"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3295"/>
    <dbReference type="eggNOG" id="ENOG502ZJJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2823914_0_0_3"/>
    <dbReference type="OrthoDB" id="2052352at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7673" checksum="5A0A88D0BFEE996E" modified="2013-03-06" version="1" precursor="true">MLKQITLSSVFWRNCIIAYIIVGFSSSLIAEFYQSFQISNQWENGERLSRLVSIGVAYSMKENLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z826</accession>
    <name>K9Z826_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220609.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2820"/>
    <dbReference type="EnsemblBacteria" id="AFZ54887">
        <property type="protein sequence ID" value="AFZ54887"/>
        <property type="gene ID" value="Cyan10605_2820"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2820"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2997"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105064_0_0_3"/>
    <dbReference type="OMA" id="PTAIAWC"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="222" mass="25559" checksum="F66AEA201B12F601" modified="2013-03-06" version="1">MSSEAKKQTINDLVEKHLSNNQPSAWFEELYASAKSNPSYIPWAKLEANSHLREWLKNHQGIKKNEQLTAVVIGCGLGDDAELLQETGFQVTAFDVSPTAINWCRQRFPNTKVNYVCEDIFQLPRIWEKQFDFVWECRTIQALPLEVRENAINAVVSLVKVTGTLLMFTHYHTEKKPPSGPPWALSENDLDYFIRLGLKENKRSIDFLHEGKTNTLLLEYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z835</accession>
    <name>K9Z835_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2830"/>
    <dbReference type="EnsemblBacteria" id="AFZ54897">
        <property type="protein sequence ID" value="AFZ54897"/>
        <property type="gene ID" value="Cyan10605_2830"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2830"/>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2635006_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7642" checksum="14218E920175CF9E" modified="2013-03-06" version="1">MVYFEKEDILHLTISEEDEFQSVEISPNITLELNQNGEIIGLEIIKASNFIQDSILDSSQVKLMQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z881</accession>
    <name>K9Z881_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3309"/>
    <dbReference type="EnsemblBacteria" id="AFZ55354">
        <property type="protein sequence ID" value="AFZ55354"/>
        <property type="gene ID" value="Cyan10605_3309"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3309"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_3_0_3"/>
    <dbReference type="OMA" id="MSNNRSG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10676" checksum="34D9E01D30893935" modified="2013-03-06" version="1" precursor="true">MMSQEEKNMTFIIGLLLGSSIGTIATLLLTPRTGKENRKIIAKTAQALPEMTEDISSTMQNNTLRLSSSVMTKWHNTLERLQVAIAAGIEASRLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A6</accession>
    <name>K9Z8A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2527"/>
    <dbReference type="EnsemblBacteria" id="AFZ54608">
        <property type="protein sequence ID" value="AFZ54608"/>
        <property type="gene ID" value="Cyan10605_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2527"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2681"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126947_0_0_3"/>
    <dbReference type="OMA" id="FGDEHYV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17208" checksum="F770F86726BAD12F" modified="2013-03-06" version="1">MIHHISIRTADIIGAIAFYELLGFTVKERFTTGYTLACWLEGEGGRLELMQIPEPKPAPDAFNDEHYVGYYHFTLDITEKQIDLPTWLEQLKQKFWRESQKDNSKISPLKILLPPQQQMIENQVYEVAFIADIDNLPIEIIRLCEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B5</accession>
    <name>K9Z8B5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ordered locus">Cyan10605_3394</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221154.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3394"/>
    <dbReference type="EnsemblBacteria" id="AFZ55436">
        <property type="protein sequence ID" value="AFZ55436"/>
        <property type="gene ID" value="Cyan10605_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3394"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3614"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_3"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="126"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ55436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="45270" checksum="6048CBEA5D8058C6" modified="2013-03-06" version="1">MSRSYLFTSESVTEGHPDKICDQISDTILDALLAQDTSSRVAAEVVVNTGLVLITGEITSQANVNYVDLARKKIAEIGYTDASNGFSANSCAVLVALDEQSADIAQGVNQAQEKRESLSEDELDSIGAGDQGIMFGYACNETPELMPMPISLAHRLSRRLATVRKSGELPYLGPDGKTQVTIAYENDQPVGIDTILISTQHSETIGNITDNDKIQATLKEAIQEVVINPVFSDLNLKPSDKTRFLLNPTGKFVIGGPQGDSGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSASYAARYVAKNIVAAGLASKCEVQLSYAIGVAQPVSILIETFGTSTVSEDKLLPLVKANFDLRPAGIIQMFDLRNLPAQRNGRFYQDVAAYGHFGRIDLDLPWERTDKAAILRDSISQNLAFTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B9</accession>
    <name>K9Z8B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220548.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54825">
        <property type="protein sequence ID" value="AFZ54825"/>
        <property type="gene ID" value="Cyan10605_2756"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2756"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2926"/>
    <dbReference type="eggNOG" id="COG2314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158532_0_0_3"/>
    <dbReference type="OMA" id="QAFNAKY"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13303" checksum="4B006AE8A0C1E442" modified="2013-03-06" version="1" precursor="true">MKQKSIAAVLAFFVGGFGVHKFYLGNNFAGILYLLLFWTFIPSILAIFDFLGLLLMSEQAFNAKYNLQEVNKLNLLQSSQNDNIDKLKKIKELYDQGIITAEEYEEKRRKFLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D0</accession>
    <name>K9Z8D0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ordered locus">Cyan10605_2925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220706.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2925"/>
    <dbReference type="EnsemblBacteria" id="AFZ54987">
        <property type="protein sequence ID" value="AFZ54987"/>
        <property type="gene ID" value="Cyan10605_2925"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2925"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3112"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_3"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="366" mass="40793" checksum="AAA951E9E5724618" modified="2013-03-06" version="1" precursor="true">MVFQYSLIASCTKTRARAGVFSTPHGEVETPRFMPVGTVGTVKGITPAQLQSAHAQMILGNTYHLHIQPGEEIIEKAGGLHNFMGWQQPILTDSGGFQVFSLADLRQITDDGVKFRSPKDGRIINMTPENSIRIQNSLGADVIMAFDECPPATATKEEVVKAVKRTTAWLERCISAHKKPEQQALFGIVQGGIYPELRTQSAKELIEFNLPGYAIGGVSVGEKPELIHQIVQWTTPLLPSNKPRYLMGVGSYKEMVVAIASGIDLFDCVIPTRLGRHGAALVQGERINLKNAQYKEDFTPLDPECDCYTCKNFTRAYLNHLIRAKEMLGYILLSLHNIYELINFTRKIRQAIINDSFVEEFGHYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F9</accession>
    <name>K9Z8F9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221157.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3397"/>
    <dbReference type="EnsemblBacteria" id="AFZ55439">
        <property type="protein sequence ID" value="AFZ55439"/>
        <property type="gene ID" value="Cyan10605_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3397"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043658_0_0_3"/>
    <dbReference type="OMA" id="LEVPQEW"/>
    <dbReference type="OrthoDB" id="1058535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014951">
        <property type="entry name" value="DUF1822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08852">
        <property type="entry name" value="DUF1822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="467" mass="54983" checksum="DF009B7653C4D176" modified="2013-03-06" version="1">MSLDLFTAFNSEDLWLKFSDKEYDIAMEKAKNFASLAQQHQALINFLASNCLIKWLNMTYGDLIRQVNFEFEEKDLFSIWQFVNGTPLIINNLSRRLVVIPEECEDLSEFNIPQEWLDIPQLRGDYFLPVQVNLETGWLRFYGFTTYEYIKKYSYYNRYFAYYILPEHFLDDDLNLIFLFEKYQLFNHVEYQALPQFSSVEKRQFMEQLNNIEASRVRHHLNFVQWAALFADKSCRLSLYKKYQPISLGSWLENNFYQAYSQGWQNLTDLMDSLNFISSSPSVSSNGIVMRSGNVNLEYIYQINDEKQLKVAAQRLSVLPTNSVHKNQVLQALNYIMSRSHDDETRWHAAEGIWRLEPNNPNAGLWCGKRLNLGLEMGDLSLALVIGVLPKSDSQNSIFFRLYPTNNHLLPANLKVQIMDEETKVFKQLTSREGDRILQYKFWGNKGEFFWIQMSYHSTQLSEAFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H6</accession>
    <name>K9Z8H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exonuclease, RecJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221214.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3459"/>
    <dbReference type="EnsemblBacteria" id="AFZ55496">
        <property type="protein sequence ID" value="AFZ55496"/>
        <property type="gene ID" value="Cyan10605_3459"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3459"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_4_1_3"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="799" mass="93604" checksum="406315561B0F79FA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I1</accession>
    <name>K9Z8I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221182.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3424"/>
    <dbReference type="EnsemblBacteria" id="AFZ55464">
        <property type="protein sequence ID" value="AFZ55464"/>
        <property type="gene ID" value="Cyan10605_3424"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3424"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3649"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064283_0_0_3"/>
    <dbReference type="OMA" id="LPETYEY"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="266" mass="30961" checksum="0B1064B57BB74FDD" modified="2013-03-06" version="1">MTEKKVRHVLGLSGGKDSTALAVLLHKEVPEMEYFFCDTHKELQETYDYLDRIQARLGIKIHYLSENRGFDHWLAIHDGLLPSVQMRWCTVKMKIKPFEEFVGDDEAISYIGIRADENREGYISTKPNIKPVFPFKERGLVKADILRLLEESGIGLPEYYKWRSRSGCFFCFFQRKYEWVMLAQNHPDLFAKAVEYESNHQDGRTYTWNQGETLLELLERKDEIIANHEKAIAREQKKAPNRPLAEALESVLDDDDSTLPCLVCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J9</accession>
    <name>K9Z8J9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2848"/>
    <dbReference type="EnsemblBacteria" id="AFZ54915">
        <property type="protein sequence ID" value="AFZ54915"/>
        <property type="gene ID" value="Cyan10605_2848"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2848"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_4_0_3"/>
    <dbReference type="OMA" id="DCAHLSH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017584">
        <property type="entry name" value="Pyridine_nucleo_diS_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03169">
        <property type="entry name" value="Nterm_to_SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="371" mass="41751" checksum="92958CB9E784C426" modified="2013-03-06" version="1">MRLLLIGGGHSHAIALSLIRKNYLNKVNITIISDTPLSPYSGILPAYVAGYYSPQDLFIPIKKIAESKGINFILDKVIDINPEQKYVICHSGNKITFDILSIDIGSTPDKSTIKGANLYSIPAKPVLSFLDKWKKITDYYQVSKNQSLTLNIIGGGAGGVELALNIHKKLTSIMTSDNININLIHRGEKILENHNQWVSYKLTDILQAKKINLFLNSEVNAINQTEIILKTGKKISGNHHILVTQASAPLWLKNNPINTDKTGFILIKNTLQTTNYNYIFASGDIATLRENPHPKAGVFAVRQGKPLLKNLFRFIENKPLKPYFPPRNYLNIIGTGNESAVASWSYLGWESPLLWYFKNYLDLRFMNKFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N6</accession>
    <name>K9Z8N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220431.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2634"/>
    <dbReference type="EnsemblBacteria" id="AFZ54708">
        <property type="protein sequence ID" value="AFZ54708"/>
        <property type="gene ID" value="Cyan10605_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2634"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2798"/>
    <dbReference type="eggNOG" id="COG3381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498595_0_0_3"/>
    <dbReference type="OMA" id="PSVWEGD"/>
    <dbReference type="OrthoDB" id="773783at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="561" mass="64345" checksum="24F9E77699364575" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q1</accession>
    <name>K9Z8Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3538"/>
    <dbReference type="EnsemblBacteria" id="AFZ55571">
        <property type="protein sequence ID" value="AFZ55571"/>
        <property type="gene ID" value="Cyan10605_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3538"/>
    <dbReference type="HOGENOM" id="CLU_2421993_0_0_3"/>
    <dbReference type="OrthoDB" id="1835925at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10848" checksum="F337E4A65C6A3654" modified="2013-03-06" version="1">MELIISLKKQHKTVAEIANKLGRSYNSIRCFTHYYNLPPSRWTEKENEILRANYFHTPAKLLAKRLNRSLRSVYVQANKLGLRKNRIKYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R6</accession>
    <name>K9Z8R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221301.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3553"/>
    <dbReference type="EnsemblBacteria" id="AFZ55586">
        <property type="protein sequence ID" value="AFZ55586"/>
        <property type="gene ID" value="Cyan10605_3553"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3553"/>
    <dbReference type="HOGENOM" id="CLU_2583852_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9328" checksum="434219BD394FB4B0" modified="2013-03-06" version="1">MKVDITDSVIQSADDLIDLGLTDCDRTLLQQAIIKWIEQFIDELPDNIEWYKYNDRTLAEYIKEAEYRTEQLASELSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T2</accession>
    <name>K9Z8T2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220491.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2695"/>
    <dbReference type="EnsemblBacteria" id="AFZ54768">
        <property type="protein sequence ID" value="AFZ54768"/>
        <property type="gene ID" value="Cyan10605_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2695"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2859"/>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180537_0_0_3"/>
    <dbReference type="OMA" id="VQEATSW"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8068" checksum="DBD7A23B1ECFCDDC" modified="2013-03-06" version="1">MLAKLTSKNQLTLPKSITKEVGDVEYFDVKLEDGQIVLTPVKIQKADAVRAKLAQLKISEDDITEAVAWARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P4</accession>
    <name>K9Z9P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221018.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3254"/>
    <dbReference type="EnsemblBacteria" id="AFZ55300">
        <property type="protein sequence ID" value="AFZ55300"/>
        <property type="gene ID" value="Cyan10605_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3254"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3469"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745594_0_0_3"/>
    <dbReference type="OMA" id="QTHQINI"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="361" mass="40829" checksum="0F090FB4FAD1023C" modified="2013-03-06" version="1">MSITLDYELFFKLGIIVTIILGIIIIFNYFKKLIVYLTEQFIPYQSRKFYSEVIKPDLSFLTIIWLLSLGDIALLINNFPPPVKVGEIILSLVISILTIWLGVKWFKPLFDNYLLDAALQSQKKINSEFLIVGKYSANAIIFLLIIFIFAQVHSINLFGLLASLGIGGLAVAFAAQKTLEQLLGGVVIYLDRPFVLDDYIGLPDGTFGRVESIGLRSTKIRVSGKGTLMVIPNSSLTQTNIENFTGAKKVISLVYLTFYRTLELDEMALIRQIILDSTKDIFGIDPKNTEVKFKQVNKNERKEFSQAQISFFLLGSEQVSMDLRRQLLNIANQNIRQKLEEYGIDFTLEDDSINVDSPITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Z4</accession>
    <name>K9Z9Z4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221128.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3368"/>
    <dbReference type="EnsemblBacteria" id="AFZ55410">
        <property type="protein sequence ID" value="AFZ55410"/>
        <property type="gene ID" value="Cyan10605_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3368"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870737_0_0_3"/>
    <dbReference type="OrthoDB" id="1192213at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="208"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="319" mass="37050" checksum="C9FCD3C27F982F13" modified="2013-03-06" version="1">MIDLNQLFSSIDPNPFVLSILAKIKHDLEVDQVFISQFNSSGELENIINGSELISKKKDSFQENSLYEISDSLIGKIKKNQQSYFTHDSDDLTEDTYPLKRAELLFPIKLKTPQVITVNEDIELWGILSIYDYNYERKWQEEQIKQIDEIISILTLAIERKIIFDKLLETQQKCQSYSLLDDQTGLANYSAFIDCLDYEWRRLAREKQPLSLILFKLRFEAEFNTRILAKIGYLIQEEIKRPADLGAYFGNNKIMIMLPNTNSSGALWVKKNIFKSLAKITNAQKSFQCVAEILTIIPEYNQDYNSIINNLEKSLPNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA50</accession>
    <name>K9ZA50_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3430"/>
    <dbReference type="EnsemblBacteria" id="AFZ55470">
        <property type="protein sequence ID" value="AFZ55470"/>
        <property type="gene ID" value="Cyan10605_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3430"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3655"/>
    <dbReference type="eggNOG" id="COG5450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179376_0_1_3"/>
    <dbReference type="OMA" id="KENNYAY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9796" checksum="36241B3EB9E6994A" modified="2013-03-06" version="1">MFLYLHILHKKMRTNIDLDDSLLEEAFRLTNVRTKKELVNMALKELIRSRKKLNLLDLSGKIEFREDYNYKELRNNKNVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAB7</accession>
    <name>K9ZAB7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2063 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221031.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3267"/>
    <dbReference type="EnsemblBacteria" id="AFZ55313">
        <property type="protein sequence ID" value="AFZ55313"/>
        <property type="gene ID" value="Cyan10605_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3267"/>
    <dbReference type="eggNOG" id="COG3219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986703_0_0_3"/>
    <dbReference type="OMA" id="IWARPRL"/>
    <dbReference type="OrthoDB" id="1554318at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018640">
        <property type="entry name" value="DUF2063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044922">
        <property type="entry name" value="DUF2063_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09836">
        <property type="entry name" value="DUF2063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2063" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="32868" checksum="2B55FBB30FEC2324" modified="2013-03-06" version="1">MKSPTLLKLEQQFLKSLRTDKNSPWLESIIIPAHQRNTEEVLDLYLNRARTRTIAPFHEIFPACEAIMGSELFDRFVDDFYLHSHCDNVTVLDYANSFMDYLTVVKPEFFEPLIPTIEEQTIDWSRLLIDVALTEWRLRRAETAPTLRKNNPEELLHRLRVKKLHGYRPKLEHGTRIPFSCYCLVPLTKAHKCPIEPRHLIAGERKPYLIWRKPDNQVEIRTISEDEARLLRSCNGHLSVTAILQEETHFGFSREETLDRISEAIKLGWIVSLFDPMSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAJ9</accession>
    <name>K9ZAJ9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221141.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3381"/>
    <dbReference type="EnsemblBacteria" id="AFZ55423">
        <property type="protein sequence ID" value="AFZ55423"/>
        <property type="gene ID" value="Cyan10605_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3381"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119719_0_0_3"/>
    <dbReference type="OMA" id="WTSHITQ"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17135" checksum="FA2FD9768ED05DE7" modified="2013-03-06" version="1">MHQHIVEVNVACSVEEVYNLWQRVENVPRLMPLVKEVEIIKGSDDLSLWKFGLGFPLLTQWTSHITQRVPQKLIAWESVSGLKNRGCAEFFSTDKGCRLCLTVAFDLPGGVVGTLLKTVNIDRWLEANLVESLNRFQSLIEKEVLRQKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ52</accession>
    <name>K9YZ52_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ordered locus">Cyan10605_0018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217911.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0018"/>
    <dbReference type="EnsemblBacteria" id="AFZ52179">
        <property type="protein sequence ID" value="AFZ52179"/>
        <property type="gene ID" value="Cyan10605_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0018"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.19"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_3"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="36285" checksum="0BA431D6645AFB00" modified="2013-03-06" version="1">MSHSATLTVSSILPQQVSDNNRLRLFSGSANIGLATEVARYLGMDLGPMIRKRFADGELYIQIQESIRGCDVYLIQPCCHPVNDNLMELLIMIDACRRASARQITAVIPYYSYARADRKTAGRESISAKLVANLVTTAGAHRVLAMDLHSAQIQGYFDIPLDHVYGSPVILDYLNHKNIEDLVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVMNVIGDVKGKNAVLVDDMIDTAGTLLEGARLLKKEGANKIYACATHPVFSGPAISRLSSDVFEEVIVTNTIPLPVDSYFPQLKVLSVANLLGETIWRIHEDSSVSIMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZG0</accession>
    <name>K9YZG0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218031.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0142"/>
    <dbReference type="EnsemblBacteria" id="AFZ52299">
        <property type="protein sequence ID" value="AFZ52299"/>
        <property type="gene ID" value="Cyan10605_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0142"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
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        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13439" checksum="D24694D01914B6E6" modified="2013-03-06" version="1">MNNQQICTPQGIIDHNNESLFQEELLKFIDNTKEKDVVVDFKGVEFVDSSGLIALVRIYQEAKKQEKNLYLFNVSPSVRMIFEISRLDKVIGIRDKDYRQQLESDDSTDAGAPSVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZP4</accession>
    <name>K9YZP4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0271"/>
    <dbReference type="EnsemblBacteria" id="AFZ52421">
        <property type="protein sequence ID" value="AFZ52421"/>
        <property type="gene ID" value="Cyan10605_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0271"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.281"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_0_3"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="85"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="327"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="468"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="575" mass="64629" checksum="BA6D44B992936660" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z018</accession>
    <name>K9Z018_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0407"/>
    <dbReference type="EnsemblBacteria" id="AFZ52551">
        <property type="protein sequence ID" value="AFZ52551"/>
        <property type="gene ID" value="Cyan10605_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0407"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.430"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042515_0_0_3"/>
    <dbReference type="OMA" id="FVPMQFN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="331"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="472" mass="53294" checksum="C5543C290FBDDDC0" modified="2013-03-06" version="1">MPKPSCLNIGAYFLIVMGLTVCFGWYNQIDSLIQIHPDFVPMQFNTALGFVFLGLSIFGINYEYYFAARCFASLVFLLAFLILIQYIFGFNIGIDQLFIEHYITVATSHPGRMAPNTALCFLLSSLSLWFLTYFPPRIKFLSTASILSAFVTGFGTVAFFGYLSEVETAYGWGMLTQMAIHTSVGFVVAGFSLIVDSQCISLRRFQRLPFLMLPITSGIVGLTITISFWQSLEGSESMIRAECVNYRHNLISEGILIMGVIFSIVLGATIWLTQKYKEQVMKLKQAQYQILQLNSQLEKISYLDALTGVANRRLFDVKLSQEWKKAYNNQSYLGLIMLDIDYFKNYNDYYGHRKGDECLKQVAEAICEVVRSENDLVARYGGEEFVIILPNTDKQSLDAIALRTLNSIRQKSIPHENSPISKSITASLGGYTIIPEYVGLSELENFMNKADQALYEAKSKGRNCIVIRSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z097</accession>
    <name>K9Z097_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218320.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0445"/>
    <dbReference type="EnsemblBacteria" id="AFZ52589">
        <property type="protein sequence ID" value="AFZ52589"/>
        <property type="gene ID" value="Cyan10605_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0445"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.471"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_3"/>
    <dbReference type="OMA" id="DLVSGWK"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35976" checksum="703E2EF181D8A15B" modified="2013-03-06" version="1">MDLSLVIPIYNEAENIPLLINAITKSLNNTNLVYEIICVDDGSQDGSTEVLKNILMTTSCLKAIVLRRNYGQTPAMAAGFENARGNVIITLDGDLQNDPTDIPLLLQKLEEGYDLVSGWRKNRQDDALTRLLPSKIANWIIGKITGVKLHDYGCSLKAYRKELIADMNLYGELHRFLPALAYIEGAKITEIPVNHHPRRFGKSKYGLGRTFRVIMDLLTVFFIKKFLTRPMHVFGFFGLISMILGFFIGIYLSFLKLGLGRSIGDRPLLILCVLLILTGVQLFSFGLLGELLMRTYHESQKRPIYRIRDIYFNSGNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L0</accession>
    <name>K9Z0L0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0548"/>
    <dbReference type="EnsemblBacteria" id="AFZ52689">
        <property type="protein sequence ID" value="AFZ52689"/>
        <property type="gene ID" value="Cyan10605_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0548"/>
    <dbReference type="HOGENOM" id="CLU_3381471_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="33" mass="3815" checksum="E07831523F6A8DB9" modified="2013-03-06" version="1">MSSLKFCIELLEDGLKLFNISYPQPKINTDYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y8</accession>
    <name>K9Z0Y8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photosystem II reaction center protein J</fullName>
            <shortName evidence="7">PSII-J</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psbJ</name>
        <name evidence="8" type="ordered locus">Cyan10605_0693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PsbJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218560.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0693"/>
    <dbReference type="EnsemblBacteria" id="AFZ52829">
        <property type="protein sequence ID" value="AFZ52829"/>
        <property type="gene ID" value="Cyan10605_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0693"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.726"/>
    <dbReference type="eggNOG" id="ENOG5033ABP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215151_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01305">
        <property type="entry name" value="PSII_PsbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002682">
        <property type="entry name" value="PSII_PsbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037267">
        <property type="entry name" value="PSII_PsbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01788">
        <property type="entry name" value="PsbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161021">
        <property type="entry name" value="SSF161021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="1 7" id="KW-0674">Reaction center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="38" mass="3845" checksum="AEE431D6B15B97B8" modified="2013-03-06" version="1" precursor="true">MGDARIPLWIVGTVAGMGVLAVVALFFYGAYAGLGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z103</accession>
    <name>K9Z103_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallothionein family 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218575.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0708"/>
    <dbReference type="EnsemblBacteria" id="AFZ52844">
        <property type="protein sequence ID" value="AFZ52844"/>
        <property type="gene ID" value="Cyan10605_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0708"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.741"/>
    <dbReference type="eggNOG" id="ENOG50330JR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192999_1_0_3"/>
    <dbReference type="OMA" id="TQMKCAC"/>
    <dbReference type="OrthoDB" id="2014524at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017854">
        <property type="entry name" value="Metalthion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000518">
        <property type="entry name" value="Metalthion_fam14_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02069">
        <property type="entry name" value="Metallothio_Pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00859">
        <property type="entry name" value="MTPROKARYOTE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57868">
        <property type="entry name" value="SSF57868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="57" mass="5945" checksum="B2363F8FE8DCF46B" modified="2013-03-06" version="1">MTTTTVTQMKCACPSCLCIIDISQAISRDGHYYCSTACAEGHKEGEGCGHSGCGCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z131</accession>
    <name>K9Z131_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217997.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0106"/>
    <dbReference type="EnsemblBacteria" id="AFZ52265">
        <property type="protein sequence ID" value="AFZ52265"/>
        <property type="gene ID" value="Cyan10605_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0106"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.109"/>
    <dbReference type="eggNOG" id="ENOG5032YRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180814_0_0_3"/>
    <dbReference type="OMA" id="FFWFAIA"/>
    <dbReference type="OrthoDB" id="1959726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9286" checksum="130AC43A4C2C187B" modified="2013-03-06" version="1">MKEKLLLWLDRFLIADVFLVIIGFFWFAIALMGRSLGISLGWDIWYQLWQPVFNPAIGILFTGALLSWLIKKVGEKLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z158</accession>
    <name>K9Z158_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polymorphic membrane protein Chlamydia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218199.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0319"/>
    <dbReference type="EnsemblBacteria" id="AFZ52467">
        <property type="protein sequence ID" value="AFZ52467"/>
        <property type="gene ID" value="Cyan10605_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0319"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369956_0_0_3"/>
    <dbReference type="OrthoDB" id="263811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="881" mass="95729" checksum="28329CE82B055652" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z190</accession>
    <name>K9Z190_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218702.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0839"/>
    <dbReference type="EnsemblBacteria" id="AFZ52971">
        <property type="protein sequence ID" value="AFZ52971"/>
        <property type="gene ID" value="Cyan10605_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0839"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.882"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035027_0_0_3"/>
    <dbReference type="OMA" id="WPRSVRW"/>
    <dbReference type="OrthoDB" id="591769at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="64"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="445" mass="49119" checksum="5DF337F0D58351C3" modified="2013-03-06" version="1">MASKPVVTSLYSLARTSLQQSVSWYSSQRRHWNYPPNADLQGAVRDDLRALRAASEKLEQQIIKIAAFGLVSRGKSSVINALLGEKVLDTGPINGVTKWPKSVSWNPPSGKIKIELIDTPGLDEIDGETRANMAREISAQADLILFVIAGDITRTEYLALLELRQALKPLILVFNKIDLFPETDLDTIYQQLQQLSNQTHKPLFTPDEIVLISAQPQPLPIRIELPDGSVGEEWEYPAPMIQPLQEKILQILNREGKALLALNSLTQAKVAQKNIARKTIEMRDKEAEEIIWRYGKYKALIVAVNPIAFLDLMGGFVSDLMMIRALARLYGLPITSYEAGRLWQTIIKSLGSLLLGEVASMMMLGWAKTGAIISSLWENPSGFTMVASTVLTQGAIAAYGSYIVGKSTQVYLENGCTWGNYGLDTVIGEIIAQSPPDAIISRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C0</accession>
    <name>K9Z1C0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218097.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0209"/>
    <dbReference type="EnsemblBacteria" id="AFZ52365">
        <property type="protein sequence ID" value="AFZ52365"/>
        <property type="gene ID" value="Cyan10605_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0209"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.219"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052475_0_0_3"/>
    <dbReference type="OMA" id="PHNLFLM"/>
    <dbReference type="OrthoDB" id="754057at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="429" mass="49343" checksum="9BEF04EC19AECE47" modified="2013-03-06" version="1">MLWTFYSEDKNFLNKLLFLSLLILPFQTFLGILILVYISYQASVKNWSQIKNSSLTLGFIFLSLLLIVSSIFAYKSGEAWLGIVHFLPFFWVFLSLRTIVKTYEQLYTIVWSLILSSIIVVLIAIGEINFHWVTIDIIYKLFGWQLTGEGIPPGRASSVFPYANPLALYLAITIILSTGLLIKNSQKYWLNKVNLCLIFTIALNVYGLILTGSRNGWIIVFLSLIAFAIYRHWYFLLSLITFSGIIVSWASFGNLPLQNFWRKIVPNFLWQRFSDQMYVSGDRPLETLRTTQWNFCIDLIEQHPLLGWGLRNFTVLYEEKMGIYLGHPHNFFLMMGAETGLTTLGFLLGLIAIVLAKGLLIIKEEKIEQNHNIIFFSYLVAFGAYIIYNLFDVSLFDLRLNILAWVILGAISGISENVNQNEQIRIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D5</accession>
    <name>K9Z1D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218273.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0398"/>
    <dbReference type="EnsemblBacteria" id="AFZ52542">
        <property type="protein sequence ID" value="AFZ52542"/>
        <property type="gene ID" value="Cyan10605_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0398"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.421"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_4_3"/>
    <dbReference type="OMA" id="KPFDQKQ"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="21013" checksum="85D418E8B48B141B" modified="2013-03-06" version="1">MSNHKVLVIDDSMVIRRTVKGMLPDDKFEVVEAKDGAQGLELIHTCNPNLIMLDFFLPKKSGYEVFQEIQKDPRLKAIPLLLMSGRKDEVTDKIPEPFEFFSFLEKPFDQKQLIQGIRESMEKSKKLAHLQPVSSATAQTTMDSGVDSDQLQKLQAQVKHLESEVAQMKKQINQLVSFIKKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H0</accession>
    <name>K9Z1H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217915.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0022"/>
    <dbReference type="EnsemblBacteria" id="AFZ52183">
        <property type="protein sequence ID" value="AFZ52183"/>
        <property type="gene ID" value="Cyan10605_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0022"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.23"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_3"/>
    <dbReference type="OMA" id="YYRVVRN"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="31346" checksum="21914B0ABF8212FC" modified="2013-03-06" version="1" precursor="true">MIARSFSRKKNTFKQLSNVLLMVGIIITLTFIFFAFSAPLLENIGIIQDPLESLSNPINQPPNSKYWFGTTGQGYDVFSRTIFGSQAALKVVITATFLSLIIGVPLGLISGYFGGKIDKILLFLMDTIYTLPGLLLSVTLAFVVGRGVINAALALSISYIPQYYRVVRNHTTSVKTELFIEAAQAMGASPTRIIYKYLFFNVVQSIPVLFTLNAADAILILGGLGFLGLGLPEDVPEWGHDLKLALDGLPTGIWWNALFPGLAMATMVTGLSLLGEGLSERLNPLHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L8</accession>
    <name>K9Z1L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218353.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0480"/>
    <dbReference type="EnsemblBacteria" id="AFZ52622">
        <property type="protein sequence ID" value="AFZ52622"/>
        <property type="gene ID" value="Cyan10605_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0480"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.508"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_3"/>
    <dbReference type="OMA" id="FMIVVTQ"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="33680" checksum="563B1A8C698B19DA" modified="2013-03-06" version="1">MRLSTNNYNQEKYIGWWLIIPALIILTLVFIYPITRAFWMSFFQQNLGTELESIFAGFSNYSRLLGDGRFWQSLRNTTIFTAVSLTLELILGMVFALILNQAFFARGIVRTTALIPWALPTAIMGLAWAWIFNDQYGIVNDILMRLGFISENINWLGEPNRAMLSLIVADVWKTTPFIAIILLAGLQSIPSDLYEAHQMDGASPWQSFWQITIPLLTPQILIALLFRFAQSFGVFDLVQVMTGGGPAGSTEMVAIYIYATVRRYLDFGYGASLVVVTFLLLILVVALTFFLISKLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M8</accession>
    <name>K9Z1M8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218363.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0490"/>
    <dbReference type="EnsemblBacteria" id="AFZ52632">
        <property type="protein sequence ID" value="AFZ52632"/>
        <property type="gene ID" value="Cyan10605_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0490"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.519"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968980_0_0_3"/>
    <dbReference type="OMA" id="SAWIRAN"/>
    <dbReference type="OrthoDB" id="1635787at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="34567" checksum="1A2CA939DAC67ACC" modified="2013-03-06" version="1">MAIDFGSVKSYNSNRGFGFITGRFLNPHRRVFFHIKKIKAKHPEIAEKLDNEENFQGLNLWYEIEQTQKGEQVKECWLHKDEIPENHVSELSDLIGKVENIWKNIDSSKPSWLDIVTIELVGTNRKDELSLQRNNLENQRREAGERKRKDVEVERLRQIELQRERERQEVERQKQIRVDKENEVRKLSAKYSLSIDEAEELYLLLEEMRPKNFTHSKQLSMYIVKQKLGYKYKNISGILTMQDGGNEWDFHGGFPPKIYSNICKELGLDNQHTKARPIDFRSFKDVSPTDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T4</accession>
    <name>K9Z1T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218276.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0401"/>
    <dbReference type="EnsemblBacteria" id="AFZ52545">
        <property type="protein sequence ID" value="AFZ52545"/>
        <property type="gene ID" value="Cyan10605_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0401"/>
    <dbReference type="HOGENOM" id="CLU_183615_0_0_3"/>
    <dbReference type="OMA" id="ITICETC"/>
    <dbReference type="OrthoDB" id="2039087at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="88" mass="10815" checksum="44BFD6C8593E4EE7" modified="2013-03-06" version="1">MQYLFSNHAKQQLKSYGRKQIKLEWIERVIKNPDYIEVYDNLDITICETCCWKRIKEYSNRALKVVYNHRKNPPLIITVYFDRSYKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U2</accession>
    <name>K9Z1U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218860.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1000"/>
    <dbReference type="EnsemblBacteria" id="AFZ53129">
        <property type="protein sequence ID" value="AFZ53129"/>
        <property type="gene ID" value="Cyan10605_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1000"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1057"/>
    <dbReference type="eggNOG" id="ENOG5032YVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175441_0_0_3"/>
    <dbReference type="OMA" id="FGFSMQD"/>
    <dbReference type="OrthoDB" id="1966564at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025477">
        <property type="entry name" value="DUF4327"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14217">
        <property type="entry name" value="DUF4327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8173" checksum="0B6B93B7EE2FFBAB" modified="2013-03-06" version="1">MPRKQVIHPMVKLQQKVSSLVNSQIISPDDSIGKIALLFGSDWAFLKSELISFGFSMQDPVRDLLVVQKWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U6</accession>
    <name>K9Z1U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosylglycerol phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.69" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218291.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0416"/>
    <dbReference type="EnsemblBacteria" id="AFZ52560">
        <property type="protein sequence ID" value="AFZ52560"/>
        <property type="gene ID" value="Cyan10605_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0416"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.440"/>
    <dbReference type="eggNOG" id="ENOG502Z8T5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677803_0_0_3"/>
    <dbReference type="OMA" id="VLTCGEH"/>
    <dbReference type="OrthoDB" id="383846at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050530">
        <property type="term" value="F:glucosylglycerol 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012765">
        <property type="entry name" value="GGPPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09506">
        <property type="entry name" value="Salt_tol_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02399">
        <property type="entry name" value="salt_tol_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="419" mass="47177" checksum="C3DB077373D785FC" modified="2013-03-06" version="1">MTYSNLNQFSLSLNHDLCAEKLINTKNKLIIQDLDGVCMGLVKNPLHRVIDFNYVKAARNLHNHFYVLTNGEHIGKFGVNHIIEKSAPNPEIVKKEGYYLSGLAGGGVQWQDNYGKITYPGVKQEELTFLSAIPAIFEERLRNFCQNQAPFLTKEVINEALDAVILVNQVSPTINLNTFFSLFVDHPHLYLALQKEIKALMDELLDKAQKNGLKHSFFLHLAPNLGRDEEGVEIMKEATENDSGTTDFQFMLKGAVKEAGVLYILNHYYYLHTGEYPLGQDFSPQQAPNNHQELVNLVIDKFSPESMPLIMGVGDTVNSQVTWQNGKKIVKRGGSDRNFLQLIQDIGKGFNIDNIIAYVDSSGGEVKNRKPIKVENIDGNLIVTEGIAHPDDPDEPLNVNFVFPEGHRQYCQFFQKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z248</accession>
    <name>K9Z248_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hopanoid biosynthesis associated radical SAM protein HpnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218528.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0659"/>
    <dbReference type="EnsemblBacteria" id="AFZ52797">
        <property type="protein sequence ID" value="AFZ52797"/>
        <property type="gene ID" value="Cyan10605_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0659"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.695"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_2_3"/>
    <dbReference type="OMA" id="GNWPPAW"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017834">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00404">
        <property type="entry name" value="hopanetetrol_cyclitol_ether_sy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03471">
        <property type="entry name" value="HpnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="191"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="54317" checksum="7200CAD7C069CA3F" modified="2013-03-06" version="1">MKKTLFLNPPSFDGFDGGAGARYQAKREITSFWYPTWLAQPAALVTGSKLIDAPPHNQTVEDVLKIASDYELVIMHTSTPSLANDVKCAEAIKAQNRDIVIGFIGAHVAVLPEKTLVDNPVLDFVCRNEFDYTCKEIAEGKDFSEIKGLSYRDQNGNIIHNQERELIHDWDAMPSVLPIYAQHLNIKKYFIGYLLHPYISFYTGRGCPAKCSFCLWPQTIGGHNYRAKSPEAVGKEMEMAKSLFGDSVREYMFDDDTFTIDKQRAIAISEHLKKLKLTWSCNARANLDYDTLKQLRDNGLRLLLVGFESGNQQILDGIRKGIKLEVARKFMENCRKLGIKVHGTFIIGLPNENRETIEETIRFACEVNPHTIQVSIAAPYPGTELYRQALENNWFSKENLISEFGIQTSTLAYPNLSSAQIEDAVEQMYRKFYFRPQAIIPIVTEMLTDTQMLRRRLREGKEFFAYLKERKEKAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C2</accession>
    <name>K9Z2C2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA synthetase (ADP-forming) alpha subunit</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218613.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0749"/>
    <dbReference type="EnsemblBacteria" id="AFZ52882">
        <property type="protein sequence ID" value="AFZ52882"/>
        <property type="gene ID" value="Cyan10605_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0749"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_3"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_CoA_lig" evidence="1">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="34040" checksum="EB6C488E74BAB44D" modified="2013-03-06" version="1">MNWNFSPRILIQGIDQDCAQEYLQQFDGHRKDIVAGITDQNLDFTFDGIPVFSLITDAFTEGAATPSASEKEMTTSLIFSHPYLVLNAVYEAITAQIKQIVIYSESVPPLDLFKIYQKAKLKDVKILGTSQGGILIPEEYYCGLNYGNIFQKGNIAMINYADQIIAVTIAQYLQKFDLGFSKVINVGNNLLSQIDWDLWLKMLDKDKNTEVILINLGEISTKETKNLATSIEKISKPVITYLLDKNHLKSKINNNKAKVISDQIFNNLYTANSSELIKEYLQNSKGIITEDYQAISELLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I2</accession>
    <name>K9Z2I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219088.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1241"/>
    <dbReference type="EnsemblBacteria" id="AFZ53359">
        <property type="protein sequence ID" value="AFZ53359"/>
        <property type="gene ID" value="Cyan10605_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1241"/>
    <dbReference type="eggNOG" id="ENOG50331JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646550_0_0_3"/>
    <dbReference type="OMA" id="QDEARWE"/>
    <dbReference type="OrthoDB" id="2063157at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="9017" checksum="5DA05BC8A6F7C36E" modified="2013-03-06" version="1">MSSENIATITKIMESLPDSTQEKVIEYLREYLATLQEEKEWDYLVNKNQNKLIDFARKAKQEMLEGKAQLMDYEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I8</accession>
    <name>K9Z2I8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219145.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1301"/>
    <dbReference type="EnsemblBacteria" id="AFZ53416">
        <property type="protein sequence ID" value="AFZ53416"/>
        <property type="gene ID" value="Cyan10605_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1301"/>
    <dbReference type="HOGENOM" id="CLU_2022885_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939062" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13394" checksum="1D7047DEAF374754" modified="2013-03-06" version="1" precursor="true">MVKKIIAITGLALINLSVAFSASARNIVIKFPSGSYCGFYSGEIGLNDTFSLNLGKNQTLVITNPYGQEYSVIAPNGRVLPVGNYVYQDVKEYYTGNQAGVFKIRVDHLYDTPSIELQICAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J7</accession>
    <name>K9Z2J7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Photosystem I P700 chlorophyll a apoprotein A2</fullName>
            <ecNumber evidence="20">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">PsaB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">psaB</name>
        <name evidence="23" type="ordered locus">Cyan10605_0461</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-738</scope>
    </reference>
    <comment type="function">
        <text evidence="2 20">PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.</text>
    </comment>
    <comment type="function">
        <text evidence="21">PsaA and psaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="20">PSI electron transfer chain: 5 chlorophyll a, 1 chlorophyll a', 2 phylloquinones and 3 4Fe-4S clusters. PSI core antenna: 90 chlorophyll a, 22 carotenoids, 3 phospholipids and 1 galactolipid. P700 is a chlorophyll a/chlorophyll a' dimer, A0 is one or more chlorophyll a, A1 is one or both phylloquinones and FX is a shared 4Fe-4S iron-sulfur center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20 21">Cellular thylakoid membrane</location>
            <topology evidence="20 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the PsaA/PsaB family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="20"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218334.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="2/B/b=2-738"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z2J7"/>
    <dbReference type="STRING" id="755178.Cyan10605_0461"/>
    <dbReference type="EnsemblBacteria" id="AFZ52603">
        <property type="protein sequence ID" value="AFZ52603"/>
        <property type="gene ID" value="Cyan10605_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0461"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.487"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016126_1_0_3"/>
    <dbReference type="OMA" id="FEQWVAD"/>
    <dbReference type="OrthoDB" id="36958at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00482">
        <property type="entry name" value="PSI_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001280">
        <property type="entry name" value="PSI_PsaA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020586">
        <property type="entry name" value="PSI_PsaA/B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036408">
        <property type="entry name" value="PSI_PsaA/B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006244">
        <property type="entry name" value="PSI_PsaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00223">
        <property type="entry name" value="PsaA_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002905">
        <property type="entry name" value="PSI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00257">
        <property type="entry name" value="PHOTSYSPSAAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81558">
        <property type="entry name" value="SSF81558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01336">
        <property type="entry name" value="psaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00419">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="25" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 20 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20 21" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="15 20 21" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13 20 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="17 20 21" id="KW-0408">Iron</keyword>
    <keyword evidence="18 20 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 20 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 20 21" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11 20 21" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 20 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B3</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>B3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>phylloquinone</name>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <label>B</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AFZ52603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="738" mass="81919" checksum="F7F9E3ABB09A49BA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M4</accession>
    <name>K9Z2M4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218551.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0683"/>
    <dbReference type="EnsemblBacteria" id="AFZ52820">
        <property type="protein sequence ID" value="AFZ52820"/>
        <property type="gene ID" value="Cyan10605_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0683"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.718"/>
    <dbReference type="eggNOG" id="ENOG50301P4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135539_0_0_3"/>
    <dbReference type="OMA" id="WKEEVQQ"/>
    <dbReference type="OrthoDB" id="1898806at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021297">
        <property type="entry name" value="YlqD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11068">
        <property type="entry name" value="YlqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16469" checksum="282DE6B7505ACCAA" modified="2013-03-06" version="1">MDLQKLVLKRPVNVKVIVTPAWQDEAQKQLQAQINQIDQQMLQLDQQGQSAIAEIRKQGSLQANQQIENIQSQVNQKKNELLQQKNQFLQQMQQVQLLELGQEVVQAQMESFFEVQVGDNLLQKLNIEVVLRDGVIEEIRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N0</accession>
    <name>K9Z2N0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 30S ribosomal protein PSRP-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ycf65-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probably a ribosomal protein or a ribosome-associated protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the chloroplast-specific ribosomal protein cS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219190.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1347"/>
    <dbReference type="EnsemblBacteria" id="AFZ53461">
        <property type="protein sequence ID" value="AFZ53461"/>
        <property type="gene ID" value="Cyan10605_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1347"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1421"/>
    <dbReference type="eggNOG" id="ENOG503137T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132693_1_0_3"/>
    <dbReference type="OMA" id="WITDNER"/>
    <dbReference type="OrthoDB" id="1479207at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00619">
        <property type="entry name" value="Ribosomal_plastid_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038447">
        <property type="entry name" value="PSRP-3/Ycf65_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006924">
        <property type="entry name" value="Ribosomal_PSRP3/Ycf65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35108">
        <property type="entry name" value="PTHR35108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04839">
        <property type="entry name" value="PSRP-3_Ycf65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="13007" checksum="6EAF3B9088E882DC" modified="2013-03-06" version="1">METTIENQLETNIEGRFVLKVVWLDKNVALAVDYVISKGISPLTPYYFWPRTDAWQELKDELDTKTWITETEKIELLNQATEVINFWQENAGKTTMFQAQEKFPAVVFSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N6</accession>
    <name>K9Z2N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1299"/>
    <dbReference type="EnsemblBacteria" id="AFZ53414">
        <property type="protein sequence ID" value="AFZ53414"/>
        <property type="gene ID" value="Cyan10605_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1299"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1372"/>
    <dbReference type="eggNOG" id="ENOG5032QU3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048291_0_0_3"/>
    <dbReference type="OMA" id="GRWRETH"/>
    <dbReference type="OrthoDB" id="1467672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="32551" checksum="8C0C9556DC40C79E" modified="2013-03-06" version="1">MMVQPMEDYNFLNNRNQAIENYIQRVTELTQLKQTIPTNEELLKIASELGISDGEIAIAQKQSQAHFLRAQGYYSLNHWEDAIAELEEALAFNPSHLPMLHLLINAYIGRWKDKHNRQDEIQARLRIKQCLEIQPDDQESLKLLAKLDQSIRNYQYRFWSLGAITVLFCGSIIGFFISDNLSLNLFNKNDQILQNLQQELNLEIDTLRKEQTLLYNESLEQLRNQQRINNDLENRIIELQNQIKNLEQKNQELLNKINQNQSSENPFNQIPESEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P5</accession>
    <name>K9Z2P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218576.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0709"/>
    <dbReference type="EnsemblBacteria" id="AFZ52845">
        <property type="protein sequence ID" value="AFZ52845"/>
        <property type="gene ID" value="Cyan10605_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0709"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.742"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_1_3"/>
    <dbReference type="OMA" id="HAICKMA"/>
    <dbReference type="OrthoDB" id="1878999at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="154" mass="17709" checksum="DAABA4C0F5CD95F3" modified="2013-03-06" version="1">MYDKILVSLDRSPIAQSVFETALYLGKNCHSQLNFLHVLSQETTETPLSFAPYSFTYDTEIIKELQHQWEKYKQESIEMLQYWTNQAKDQGLKAEFNQIYGHPGTIICQQAQEWGANLIVMGRRGHSTVSELLLGSVSSYVIHRSHCAVHLVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S1</accession>
    <name>K9Z2S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219178.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1334"/>
    <dbReference type="EnsemblBacteria" id="AFZ53449">
        <property type="protein sequence ID" value="AFZ53449"/>
        <property type="gene ID" value="Cyan10605_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1334"/>
    <dbReference type="eggNOG" id="ENOG5032YCP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171052_1_1_3"/>
    <dbReference type="OMA" id="WKACALA"/>
    <dbReference type="OrthoDB" id="1977410at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10804" checksum="BC3B8BE38DD2CCDD" modified="2013-03-06" version="1">MTHNNQCTSACRYCRFYSPEGRRGGMCSQLGVSVKAHWKSCHFASPVFDNNWQPLPDIALLEKSFSLGCATPQVNFTIESNKVTESNVNSTEEIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S2</accession>
    <name>K9Z2S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0526"/>
    <dbReference type="EnsemblBacteria" id="AFZ52668">
        <property type="protein sequence ID" value="AFZ52668"/>
        <property type="gene ID" value="Cyan10605_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0526"/>
    <dbReference type="eggNOG" id="ENOG5032R6V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329758_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="870" mass="99312" checksum="36C7C93AE539DF19" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S4</accession>
    <name>K9Z2S4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1394"/>
    <dbReference type="EnsemblBacteria" id="AFZ53506">
        <property type="protein sequence ID" value="AFZ53506"/>
        <property type="gene ID" value="Cyan10605_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1394"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1472"/>
    <dbReference type="eggNOG" id="COG1612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041525_0_0_3"/>
    <dbReference type="OMA" id="IRRLVWK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="34673" checksum="4F371F2ABE9654F6" modified="2013-03-06" version="1" precursor="true">MAFFNMTDSALYNSFFSFSSSHPLRWIRWLIWKIAIATLALMAIGAATRVMNAGLACPDWPLCYGKIVPTQEMNLQVFLEWFHRLDAALIGFTTIILVIASWWHRRKLPQWLPYASSFALFLIIFQGILGGLTVTELLRFDIVTAHLGTALLFFGTLIAIGSSLSEYQGTATDVSKLTLIGAIASIFVYIQCLLGGLVASQWALHQCFAGNQLCFVMNSHIIGVLPATIATITLVILARKTPALSLKLRNLTKYITVILVSQILLGIATFYLHLQVEPLTVAHHTMGAALFGMLITFTVYTLRDEDTTISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V0</accession>
    <name>K9Z2V0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1371"/>
    <dbReference type="EnsemblBacteria" id="AFZ53484">
        <property type="protein sequence ID" value="AFZ53484"/>
        <property type="gene ID" value="Cyan10605_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1371"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1448"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_1_1_3"/>
    <dbReference type="OMA" id="GFAWFQK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="31045" checksum="16F3505DACC68C76" modified="2013-03-06" version="1">MILAGKKKIKEKEQSAFWRNFHRYWDLLSVLVPQNLNTRYRGSYLGVYWSLLNPIIMTGLYTTIFGSTFASYYNDSLISYILAAFTGLLVINFYNSSTTQALSSIVVNGDLLNKIKLPIPVFPLSMIAANIFQFMISSFPLLAIVTLVNSKNPLYIFLLLIPFFSLVLVCTGVGLFVSALFVFFRDLGYFYEITTFVMWITSPVFYPAEIVPPRIQPILGLNPLVSIIESLRDISLMGNIPSAMLLFKGILAGVIILTLGILFFRKFESAFMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X0</accession>
    <name>K9Z2X0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ordered locus">Cyan10605_0797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218661.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0797"/>
    <dbReference type="EnsemblBacteria" id="AFZ52930">
        <property type="protein sequence ID" value="AFZ52930"/>
        <property type="gene ID" value="Cyan10605_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0797"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.839"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_3"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="8930" checksum="C2A44F4EF64FC492" modified="2013-03-06" version="1">MNQEILEKVKEIVVEQLDVDADKVTPEANFVNDLDADSLDVVELVMALEEAFEIEISDEEAEKIATVGAAVEHIESKTTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z303</accession>
    <name>K9Z303_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218696.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0833"/>
    <dbReference type="EnsemblBacteria" id="AFZ52965">
        <property type="protein sequence ID" value="AFZ52965"/>
        <property type="gene ID" value="Cyan10605_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0833"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.876"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_3"/>
    <dbReference type="OMA" id="IEVKAYH"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
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        </location>
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        <location>
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        </location>
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        </location>
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            <begin position="1875"/>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="1528"/>
        </location>
    </feature>
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        <location>
            <begin position="1552"/>
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        </location>
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            <end position="608"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1509"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="2179" mass="242015" checksum="9244677F46BFD1CE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z348</accession>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Cyan10605_0880</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFZ53010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="468" mass="50375" checksum="AB4D6F2C8A6A237F" modified="2013-03-06" version="1">MGWLSKVLVLTFFLSAIDAFSLIKPQATMCWLKVSANQIVGFGQNGKDGIDGKNGDTGKDSESLTIFADGSPLNLNLSGQDGLAGENGSAGENAICENQPVNVNYNLVGADGGDGGTGGNGGDGGGGGSLTIYSTDKNYLQQIYVQAGGGKGGEAGRGGNGGKGCQCPQPYWTVEFCNGSPGSPDYSCGTKEFRCLNGENGKNGRSGRDGRDGKLGTLTLINSDKPLPPDRISASVKMNELKSRGFSLSKNVWEVRSGATSLFAPNSVIDDQYLELVERIENSVVLIWNAPQSFDSFADRTLTLELKDDRSVDIKVPSDIWLQTNTIPKRNVTELFVFNAIRADEATKLKSEGISGSGLSVQWELTDTAQRSDLISTSFYLKYSVSNSGEARFRPVSDYILRFEGEIPPQMVRYSNNRFILDIGQLPIDPRYLEPDRAIQLDLTVTRTFGDNSATQTLTEKTILGPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z367</accession>
    <name>K9Z367_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">CutA1 divalent ion tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ53030">
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        <property type="gene ID" value="Cyan10605_0900"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12607" checksum="8A672C5D87AAD908" modified="2013-03-06" version="1">MEQRKNHIVILVTTGNQIEAKKIARVLVEEKLAGCVNFYPVTSVYRWQNEICEDAEWQLVIKTDEQLFSTLSARIQDLHSYDVPEIIALPIVNSSMAYIQWLQDSLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z383</accession>
    <name>K9Z383_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219341.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1504"/>
    <dbReference type="EnsemblBacteria" id="AFZ53614">
        <property type="protein sequence ID" value="AFZ53614"/>
        <property type="gene ID" value="Cyan10605_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1504"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1595"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125966_0_0_3"/>
    <dbReference type="OMA" id="DLFVHHF"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="16459" checksum="E392C03506919B81" modified="2013-03-06" version="1">MAQIKSVSQQKLQSIQGGMALFYTPQSSHETMLVQIPPHTIDDLFVHHFQTDQLLVVKGNFVLVVLQNRQYQYLHLTENNPQVITIPPGIPHGAINLSNDSCLLVNAVLRHGETHVKDYQPIKRPFAYNLDLVKKLTNQQLVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M7</accession>
    <name>K9Z3M7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">Cyan10605_1703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219533.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1703"/>
    <dbReference type="EnsemblBacteria" id="AFZ53806">
        <property type="protein sequence ID" value="AFZ53806"/>
        <property type="gene ID" value="Cyan10605_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1703"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1809"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_0_3"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="337"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="44880" checksum="B8C948BE8660A72D" modified="2013-03-06" version="1">MKVLVLNAGSSSQKSCLYDLDSRGKKPNFVSPIWEATIDWTLNLGHTLLKVKSNGQEYSTYLSDHNRLESIKTMLKTMVEGETKVLEHLSDIDVVGHRVVHGGTKYSQATLINSEVKATIEKLIPLAPNHNPAHLEGIESVENILGDIPQVAVFDTAFHTNIPLYAKIYPLNHEFYKRGIQRYGFHGISHEYVSQRTSEILQQPLKNLNLVTCHLGNGCSITAVKNGQSVNTTMGFTPLEGVMMGTRCGSIDPAIVIHLMTEYGYDGEKINHILNKESGLWGMSEISSDLRTILKAKSENNPKAILAIEMYIFRLQEAIASMLPSLGSLDALVFTAGVGENSAFIREKVCQGLGFLGLKLDLEKNSQSLFNENIATADSNSKILIIPTKEDWAIASQCFQLMESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N4</accession>
    <name>K9Z3N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219086.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1238"/>
    <dbReference type="EnsemblBacteria" id="AFZ53357">
        <property type="protein sequence ID" value="AFZ53357"/>
        <property type="gene ID" value="Cyan10605_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1238"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136757_2_1_3"/>
    <dbReference type="OrthoDB" id="1851915at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13814" checksum="BD03F2347D6E591C" modified="2013-03-06" version="1">MTTEIINKNGKDYAVIPYDFYQKLIEDAEMLADIKAYDTAKNKSEETFPFEVVDSICLKGENPIKVYRQYRGISIIELSKKTKIDVQELEKIENNIYIATQKNLEKIAENLKIDLDMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N7</accession>
    <name>K9Z3N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218906.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1049"/>
    <dbReference type="EnsemblBacteria" id="AFZ53175">
        <property type="protein sequence ID" value="AFZ53175"/>
        <property type="gene ID" value="Cyan10605_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1049"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1110"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063676_0_0_3"/>
    <dbReference type="OMA" id="FSCNYRD"/>
    <dbReference type="OrthoDB" id="1278272at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="373" mass="41347" checksum="F94384FD36B6A0B6" modified="2013-03-06" version="1">MRTIAICGNNVKNIIASPSFVQSLQMNGVRVNCGLIHTQAIKFDPSHPEYQDHVLIKIKGFSCNYRDKTLILQTATAGVDNRFNAVGSDWVAEVVDFGSNVTDLQRGDRIINNNAYPDSGVKGLFEGVPTNHGSKEYRVLHRAKLMKIPPQMPDEVAAAFSIGAQTTYSMIRRLTLSQGENVLVTAAKSNTSLFAIQGLQKHNVNVYASTTSRKFEQELLDMGVKKVVLIDPNSPKLMSEETIASLKQEITGFDGIIDPFFDVHCDKLIPALNVWGRYITCGLYNQYSHLTGEEFNSIGLTPSTMVNMMINNIQIMGNCIGLTSDLEDAIADYVSGKLKVNIDSVFTGNQVAEFFERTYNAKDRFGKVVYCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P5</accession>
    <name>K9Z3P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218739.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0878"/>
    <dbReference type="EnsemblBacteria" id="AFZ53008">
        <property type="protein sequence ID" value="AFZ53008"/>
        <property type="gene ID" value="Cyan10605_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0878"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_5_1_3"/>
    <dbReference type="OMA" id="GRQWYGL"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="22485" checksum="42B11F032B425C09" modified="2013-03-06" version="1">MTLDVISHNPTNNKSPEFVFVLLHGWGANYHDLIALIPMLNLPSCLFLFPNAPYLHPQVPGGRAWYELDNNNEGISASLDQFYRWLLSLEDITNLPLSKTFVGGFSQGGAMSLDVGLQLPVAGVISLSGYLHFEPTSDRNPFPPTFMSHGTQDAVIPIESARVARKKLENVGVKLTYHEFDIGHEIIPAQAHLIHDFILKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S7</accession>
    <name>K9Z3S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218769.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0908"/>
    <dbReference type="EnsemblBacteria" id="AFZ53038">
        <property type="protein sequence ID" value="AFZ53038"/>
        <property type="gene ID" value="Cyan10605_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0908"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.954"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_7_3"/>
    <dbReference type="OMA" id="ICDWIMP"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="381" mass="43100" checksum="3F8995693F633114" modified="2013-03-06" version="1">MPQILVIDDDPTIQILLKRAFSSSGYSVQIAGDGQKGIELAEKIKPALIICDWLMPKLSGLEVCQFVKKNPLLNTTFFVLMTSRVSVEDRIQGLDVGADDFICKPIDLQELKARVRAGLRLHQLSKDLEIQKQLLETELNEAAEYVSSLLPDFLDDKNILINYMFIPSLHLGGDIFDYFFLDDQHLVFYLLDISGHGLKAALPSISILNLLRSRRLGILNYYSPCEVLYHLNNNFQMTEKNDKYFTIWYGVLNVKTGNLTYCSAGHPPCVLLLENNREKMNQICLKTLGLPIGMFPNIAYQNASINVGSSANLYLFSDGIYEVKNDQGDILGLDNFVELLCQFNNELNPILNFLKTYHNSSNFSDDLSIIHLKYSQQVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y0</accession>
    <name>K9Z3Y0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219004.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1153"/>
    <dbReference type="EnsemblBacteria" id="AFZ53275">
        <property type="protein sequence ID" value="AFZ53275"/>
        <property type="gene ID" value="Cyan10605_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1153"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_4_0_3"/>
    <dbReference type="OMA" id="ADHWWQQ"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="253" mass="28703" checksum="02E707C38305DA5D" modified="2013-03-06" version="1">MKFFYRWWQKYGRQVIWGLISLILTWFIYRHQGFLFNELLYRLSPSWLSSPSFDRQALYEQRTIQELSNKIETLESENQKLKQIVNYQEKYSANLIPARVIGRSPDAWWQIITIDVGSNDGVKRNQAVMSVGGLVGKISEVTSNTSRVLLVSDYNSRVGASLPRTGYQGFIKGQSTSIGLMEFYDKVSDVKVGDVVTTSNLSSIFPPDIPIGNIVAIDLNKSPAPEAEIEFTAPVDFLDWVLVDLSSKSVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B1</accession>
    <name>K9Z4B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219311.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1471"/>
    <dbReference type="EnsemblBacteria" id="AFZ53582">
        <property type="protein sequence ID" value="AFZ53582"/>
        <property type="gene ID" value="Cyan10605_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1471"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061545_2_0_3"/>
    <dbReference type="OMA" id="EAGIWHE"/>
    <dbReference type="OrthoDB" id="1615471at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010328">
        <property type="entry name" value="DUF928"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06051">
        <property type="entry name" value="DUF928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938584" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="28464" checksum="5E504293E55B8BF7" modified="2013-03-06" version="1" precursor="true">MLKAIASIVSITSIILLNPTNISAQTQDFNANSYQKNTNNSLIAQTMPRLRFKLPDRGVPGARIGGATRSGDKSTVVTAIIPPEKLALTIDDSPTIFVYLPKNDAFEANIKVVEENGKEIYTKNFTPPNEAGVLRVKLPANINLEEKKLYKWEIQLISEDDNPLTAFKLRTVGWLEKVSLPEEMQQEITTDKEWDSLNTLAEAGIWYDTLEGLALLRAENPQDNQIKKEWVELLNSVGLDSIAEISIFPEVVQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C3</accession>
    <name>K9Z4C3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ordered locus">Cyan10605_1091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218944.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1091"/>
    <dbReference type="EnsemblBacteria" id="AFZ53213">
        <property type="protein sequence ID" value="AFZ53213"/>
        <property type="gene ID" value="Cyan10605_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1091"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1155"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_0_0_3"/>
    <dbReference type="OMA" id="CQHIIVH"/>
    <dbReference type="OrthoDB" id="1764668at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="31410" checksum="D8A5CEAD1A9C333A" modified="2013-03-06" version="1">MKHWQGIINLVYEHQKQETTIKSVFSQAPFKFQNSFYPEGKSVCHSVILHTAGGIAGDDILSQNICLANSSQVLITTPAATKIYGSKGKKAIQEVKIKLEKNAYLEYLPQEMIVFNNANFEQKMRVDLEDNASWLGWEIIRFGRSARGEIFSGGNWLNYLEIWRENKPIWIDRQYFMGNSPLFYASNGLGGNPVVGNLVYIGSENIDQYISNLRHLIKEKYDENIGIGITALQQGLLCRYMGDSVSAAKEYFTLIWQFLRDKKGLDGTFKSRIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E6</accession>
    <name>K9Z4E6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219786.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1966"/>
    <dbReference type="EnsemblBacteria" id="AFZ54061">
        <property type="protein sequence ID" value="AFZ54061"/>
        <property type="gene ID" value="Cyan10605_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1966"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479728_0_0_3"/>
    <dbReference type="OMA" id="RNERQFL"/>
    <dbReference type="OrthoDB" id="1716873at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20768" checksum="A6706CAC9992EEED" modified="2013-03-06" version="1">MLAHDTLPKRNTNAVVKNKSLNQRDFRPKSSHSHNQEQTLNKNPRRVQERNSHTSQSSESIQYPLWLKSFIVLNHFSSVICGLSVGTALVMYGMTVYAPKQWTNKYHQLQNLQKQERQFTFTDEVLKDTLAESAQQQGSGFVNPDQSKPPIFLPETNATAITQKSINPVKIKKVNPIYPVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G6</accession>
    <name>K9Z4G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate ABC transporter, ATPase subunits C and D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Nitrate/nitrite/cyanate uptake transporter (NitT) (TC 3.A.1.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219209.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1366"/>
    <dbReference type="EnsemblBacteria" id="AFZ53480">
        <property type="protein sequence ID" value="AFZ53480"/>
        <property type="gene ID" value="Cyan10605_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1366"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1441"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="AFIETRE"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="36958" checksum="ADD875E81596BE48" modified="2013-03-06" version="1">MQSLMNTEEKTTTLAKTEFLTIEDISKVYPTPNGNYTVLEGVNLTVKEGEFICVIGHSGCGKSTMLNMVSGFNQPTTGKVTLKNKVIAEPGPDRMMVFQNYCLLPWKTVYENVYLAVNAVYPDKNKQEKDTIVKEHLAMVGLTEAAQKKPYQISGGMKQRVAIARALAIRPEVLILDEPFGALDAITKEELQEELLQICAEHNLTVMMITHDIDEALFLCDRLVMMTNGPSAKIGEILDIPFSRPRNRSQITEDPRYYELRNYALDFLFHRYAHSEDPTEDTIEPEPTNNKLKMAGIVGGIVIAAIAGFALFQSFTGSNTEAPNRTEQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H8</accession>
    <name>K9Z4H8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Allophycocyanin, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_1948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cellular thylakoid membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219769.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1948"/>
    <dbReference type="EnsemblBacteria" id="AFZ54044">
        <property type="protein sequence ID" value="AFZ54044"/>
        <property type="gene ID" value="Cyan10605_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1948"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2070"/>
    <dbReference type="eggNOG" id="ENOG502Z7X0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="CIRDMDY"/>
    <dbReference type="OrthoDB" id="1494063at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12126">
        <property type="entry name" value="APC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006245">
        <property type="entry name" value="ApcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34011:SF3">
        <property type="entry name" value="PTHR34011:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01337">
        <property type="entry name" value="apcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="11 12" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="8 12" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 12" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="17322" checksum="01B365BFD7E6CCC4" modified="2013-03-06" version="1">MQDAITAVINSSDVQGKYLDAGSLGKLKTYFQTGQLRVRAASVISANAATIVKEAVAKSLLYSDVTRPGGNMYTTRRYAACIRDLDYYLRYATYAMLAGDASILDERVLNGLKETYNSLGVPISSTIQAIQAMKEVTASLVGADAGKEMGVYFDYICSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S3</accession>
    <name>K9Z4S3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4010 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219314.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1474"/>
    <dbReference type="EnsemblBacteria" id="AFZ53585">
        <property type="protein sequence ID" value="AFZ53585"/>
        <property type="gene ID" value="Cyan10605_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1474"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1564"/>
    <dbReference type="eggNOG" id="COG3174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036781_1_1_3"/>
    <dbReference type="OMA" id="GTMLDHV"/>
    <dbReference type="OrthoDB" id="1352103at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025105">
        <property type="entry name" value="DUF4010"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13194">
        <property type="entry name" value="DUF4010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4010" evidence="8">
        <location>
            <begin position="183"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="418" mass="44945" checksum="E6B67BB7F7C54A2A" modified="2013-03-06" version="1">MDLVIISRLTIALTLGLIIGIERGWSNRESPEELGSDGLRNFGLVGLLGGITALLAEEWGWGILGVTFLGFAILVSTSYVLTAQKSQDYGTTTEFALLITFLLGALVVKDLSLESIAVAVIVSWLLKLKSEIRQMLIWLKQEELIATLKVLLLALVTLPLLPNQDLGPWNAINPRAIGLLVLLIVSISYVGYFIIRLWKDKSGVLLIGFLGGFASSTATTIALSRMAKQGQGQTKILATAIALATGTMAPRLLLQITVINSSLAKQLAIPLTILGLTPILIALIFIWRGIKEKNQEVPITLSNPVELGLAVQYALILIVLSLLIKAGEQWFGETGVYLVSALSGLADVDAVSISLARAVNQNMSLSVAKISIFIAVFMNTLVKVALTRFIGGKELARWCAVIILLTLTFSGITIFVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z9</accession>
    <name>K9Z4Z9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2160"/>
    <dbReference type="EnsemblBacteria" id="AFZ54246">
        <property type="protein sequence ID" value="AFZ54246"/>
        <property type="gene ID" value="Cyan10605_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2160"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2295"/>
    <dbReference type="eggNOG" id="ENOG50319U8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134405_1_0_3"/>
    <dbReference type="OMA" id="SDDWEEM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021498">
        <property type="entry name" value="DUF3155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11352">
        <property type="entry name" value="DUF3155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="13047" checksum="0C2CA5649499AABC" modified="2013-03-06" version="1">MKEDIRLARKRKRKSRRRLEGRKILELVPHYHIESGEDKPVTAARKHIRANGITPPAVLVVKRNEHTTDRYFWAEKGLFGAQYVEENHFLFPSLRIIKPQVKGTAPILSTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z528</accession>
    <name>K9Z528_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220006.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2195"/>
    <dbReference type="EnsemblBacteria" id="AFZ54281">
        <property type="protein sequence ID" value="AFZ54281"/>
        <property type="gene ID" value="Cyan10605_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2195"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_0_3"/>
    <dbReference type="OMA" id="ARFIINY"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="458" mass="52374" checksum="C6529D9D886DEF4C" modified="2013-03-06" version="1">MNYKTIRILLTNNISDECNDYLQFTCEQSNKLYNSTVFLIRQSHFEDCPRNIYFDKNDLLRSSFKLRKVKANYPNLCKELKTNVHYQAIGGSQGQQTIKSVAEAFKAYNQLLSLWFKGEIEHKPKMPSYRKNGLYAVSFTKQQIKITIDGYCRLPIPKTQKDELVTKELIIPSAKGVNSHNIAEVRIVPSLGKLWAEFVYKTPEVKATELNYSQALGIDTGVSNLITAVSTKGKSFILCGKRLKFINQKYNKTVAQYKNGKSEFYWDEFLDEITHKRNCQVKDSINKYARFIINYCLNNRIGDIVFGWGQGVKSNANLGKGNNQNFVQLPTVRLKNRIKELADEVGIRFTETEESYTSKSSFLDNDLLPKYGEKPREYKFSGKRINRGLYKTAKSYLINADCNGAINILKKVSTQLGITLAEVSKEALTLPKRYNVNSLTKVYRKRSEQVLTCVATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z534</accession>
    <name>K9Z534_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ycf66 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219397.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1561"/>
    <dbReference type="EnsemblBacteria" id="AFZ53670">
        <property type="protein sequence ID" value="AFZ53670"/>
        <property type="gene ID" value="Cyan10605_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1561"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1658"/>
    <dbReference type="eggNOG" id="ENOG502ZMRW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076895_0_0_3"/>
    <dbReference type="OMA" id="SRQVDDW"/>
    <dbReference type="OrthoDB" id="1866318at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010004">
        <property type="entry name" value="Uncharacterised_Ycf66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07444">
        <property type="entry name" value="Ycf66_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="31511" checksum="7950E233B7FAD91B" modified="2013-03-06" version="1" precursor="true">MVNFGFNSASVLGIVLALAGAGLYLMRSVRPEVSRDHDIFFAAVGLLCGFILFFQGWRLDPILQFSQLLLSGSAIFFAVESIRLRGATSEKVRGSRANSYVEDDRPVNRRVYRAELDQTDAYDDYYEEEEIPRRRLQGTAVRSPRPTTGYEENPRPRRPRRPSSSYNQEPPNPRSRNTSRTRPSRSNYEDWQETPDHWDDESSSPRQDYSRPRNDRGVSPTTGARPKKRRPKSADDIVSSVGTEYVDYQPIEPEQSDYDDSPKGDRPSNPDNFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z574</accession>
    <name>K9Z574_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219292.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1452"/>
    <dbReference type="EnsemblBacteria" id="AFZ53563">
        <property type="protein sequence ID" value="AFZ53563"/>
        <property type="gene ID" value="Cyan10605_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1452"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1540"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_4_3"/>
    <dbReference type="OMA" id="GMTADRT"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26015" checksum="F747EE04415098B8" modified="2013-03-06" version="1">MSEVEKILLVDDEPGIRESVQAYLSCNDDWDVKVASNAKEAWDKIQEDIPDLIISDIMMPEVDGLQFLAQLRQDSRYSNVPVVFLTAKGMTSDRIEGYTAGCDAYLPKPFDPDELEAIVANLLAKQRNSKDNKVSSNVQLDELLRDVKDIKDRLEGSGKFTTVDSPIKIDLTPREQSVLDLVAQGLMNKEIAKTLDTSVRNVEKYVSRLFSKTGTNSRTELVRFALKQGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E0</accession>
    <name>K9Z5E0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer region-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219345.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1508"/>
    <dbReference type="EnsemblBacteria" id="AFZ53618">
        <property type="protein sequence ID" value="AFZ53618"/>
        <property type="gene ID" value="Cyan10605_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1508"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1600"/>
    <dbReference type="eggNOG" id="ENOG502Z7MI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048100_0_0_3"/>
    <dbReference type="OMA" id="NWQILQQ"/>
    <dbReference type="OrthoDB" id="1118296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938675" evidence="2">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="237"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="42685" checksum="0681F7BEA7F28076" modified="2013-03-06" version="1" precursor="true">MARILYFLPLLIILAGCSGNQALESRFAPDSQLNDNTTNTTDGANNPNQTDNSTLADNPENNSDKINLPSNFPQIIPIYEPSTLINVNQQTIKWRSPDPLNLIVNYYQQELSANNWQITKSQENSINATHQGDNLTLSLILTPQGSETELSLTYNTSESANNSSLDTPTENTENTVSEDLTPPLQELARLGIVSNSEVINPYNTISRREYARWLVQTNNLLFQDVNSKLIREANPNSKPIFTDVPVSDPDFAVIQGLAEAGLIPSPLLKQGEFTSFNPDKPLTRENLITWKVPLDFREKLPNVTLDALKETWGFQDLSKIDPGAWSALYLDWQNGESANTRKAFGYIILFQPQKEVTYDEAARVLSSFGTNTDISYLKNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M0</accession>
    <name>K9Z5M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2361"/>
    <dbReference type="EnsemblBacteria" id="AFZ54444">
        <property type="protein sequence ID" value="AFZ54444"/>
        <property type="gene ID" value="Cyan10605_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2361"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2507"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_1_1_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9353" checksum="76EB5E9401AF8294" modified="2013-03-06" version="1">MTDWEKLESMSDENIDFSDCPEITPEMAKNAVIRRGLKSPEKQSLTLFLDAEIVNWYKENEIKHQTEINDLLRDYIKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q7</accession>
    <name>K9Z5Q7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220208.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2402"/>
    <dbReference type="EnsemblBacteria" id="AFZ54484">
        <property type="protein sequence ID" value="AFZ54484"/>
        <property type="gene ID" value="Cyan10605_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2402"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2548"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_3"/>
    <dbReference type="OMA" id="ISTHCFQ"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="16862" checksum="77CE2379F8E7C50E" modified="2013-03-06" version="1">MTSLNVGDRAPDFTLPSAEGKNVSLSDFLGKKSVVIYFYPKDDTPGCTIESCTFRDSYEEFKEAGAEVIGISSDSPQSHQQFASKYQLPFILLSDSQGKVRKLFDVPNVLFLLPGRVTYVIDKEGIVRHIFNSMMDFKAHVDEALKTIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R7</accession>
    <name>K9Z5R7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220218.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2412"/>
    <dbReference type="EnsemblBacteria" id="AFZ54494">
        <property type="protein sequence ID" value="AFZ54494"/>
        <property type="gene ID" value="Cyan10605_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2412"/>
    <dbReference type="eggNOG" id="ENOG502ZMIX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182106_0_0_3"/>
    <dbReference type="OMA" id="ISEQNCY"/>
    <dbReference type="OrthoDB" id="2199432at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="8779" checksum="CAE0F5FB703A6736" modified="2013-03-06" version="1">MNIILSSKLQQKLTKMAQKTQKSEQEVIIEALEKHLNTPQISEQNCYDLALELEVIGIAEDLPSDLSTNPDYFMGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R9</accession>
    <name>K9Z5R9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220259.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2455"/>
    <dbReference type="EnsemblBacteria" id="AFZ54536">
        <property type="protein sequence ID" value="AFZ54536"/>
        <property type="gene ID" value="Cyan10605_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2455"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2600"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_4_1_3"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="27718" checksum="0C9B95088CF48773" modified="2013-03-06" version="1">MYRLVIDPQQKQGNCIILKSDQEHYLRRVVRLNSGDDFIAMDGRGNCWQVKLTVTGNEIVTSFRENRELTTAVSLIVALPKGSGFEDIIRCTTELGVTKLYPAISDRTLLKPKENKLERWRKIALEAVEQSERQILPYIAEPMPIKVLFEQFKLNNNPKYIASARSNAPHLMEFCQQDFQDNPPSEIIIATGCEGGWTPKEIENAIASGFQEVSLGKRILRAITAPIMVMALVASYSEIFELKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T6</accession>
    <name>K9Z5T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220274.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2470"/>
    <dbReference type="EnsemblBacteria" id="AFZ54551">
        <property type="protein sequence ID" value="AFZ54551"/>
        <property type="gene ID" value="Cyan10605_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2470"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_68_3"/>
    <dbReference type="OMA" id="DVIWSIH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="664"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="738"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="823"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="965"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1220" mass="142295" checksum="7F0D9B7CFED61540" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T9</accession>
    <name>K9Z5T9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220237.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2433"/>
    <dbReference type="EnsemblBacteria" id="AFZ54514">
        <property type="protein sequence ID" value="AFZ54514"/>
        <property type="gene ID" value="Cyan10605_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2433"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2577"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_3"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="77"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="294" mass="30768" checksum="CD9268BE7C1A1AFF" modified="2013-03-06" version="1" precursor="true">MTVSTIGSLKRNPSSKRAIVGSIMTGISALCLICTVIPLFAVLYFVIIQGFSRLNTNLFTQLPPPPGLSEGGIANALIGTLVVVGLATIIAVPIGVLAAVYLSEFSGNNKLALGIRFATNVLSGVPSIIAGVFAFGLLVSTRIVGFSSVAGGVALAVLMLPTIIRTTDEALKIVPQEVRWAALGVGAYNYQAVIKIVLPAALPGIVTGVTLGIARAAGETAPLIFTALFSNFWPNVSFQGLLEPIATLSVLVYNFAILPFKPQQELAWAGSLILVFLVLATSVIARFATRKQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X3</accession>
    <name>K9Z5X3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220267.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2463"/>
    <dbReference type="EnsemblBacteria" id="AFZ54544">
        <property type="protein sequence ID" value="AFZ54544"/>
        <property type="gene ID" value="Cyan10605_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2463"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2608"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_0_0_3"/>
    <dbReference type="OMA" id="FLHQADW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="237"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="419" mass="46199" checksum="AD9A49C889AC6114" modified="2013-03-06" version="1">MVCYYLGLDFGTSGARGIVIDENQNQILCLKTADFPAQIPYYWQRGLDELLSQIPRYVTQKLDAIALDATSSTTLLLDKNGQILSEPLWYNDARGKQYLEEIKSFAPENHLVLSATSTLAKIFWWYRQGLTEKATHLLHQADWLGFLLHGKRGVSDYHNALKLGYDVESLSYPSWLENLPFFSLLPNVKAPGETIGEIIPSVAEKYQINPHCLIKAGTTDSIAAFLASGVKTSGEAVTSLGSTLVLKLLSKTKIDDSRYGIYSHRLGDLWLVGGASNTGGAVLKHFFSDDELNDLSQKIDYNTCTNLQYYPLLEKGDRFPLNNPDLEPKLSPRPDNPILFLQGLLEGIAAIESQGYKLLQKLGATPLSQVYTAGGGAKNETWRLIREKYLQVPISISANTEAAYGSALIASGLSISNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y4</accession>
    <name>K9Z5Y4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220277.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2473"/>
    <dbReference type="EnsemblBacteria" id="AFZ54554">
        <property type="protein sequence ID" value="AFZ54554"/>
        <property type="gene ID" value="Cyan10605_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2473"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2622"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_3"/>
    <dbReference type="OMA" id="TRPEQEE"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="27047" checksum="29B1AE21C054E78A" modified="2013-03-06" version="1">MNQSQCIGKVYLVGAGPGDPGLITVKGKVLLEMADVVVYDALVSPEILAMINPQAEKIDAGKRRGRHSLLQSDTTKLLIKKARQHPIIVRLKGGDPFVFGRGGEEMEDLVAAGVAVEVVPGITSGIAAPAYAGIPVTHRNYSSSVTFITGHEAAGKYRPQVNWGAIAQSSETIVIYMGIHNLGQIIPQLKEGGLKGDTDIALIRWGTTPQQEELYGTLDDILYKVEAHNFEAPAIAIIGQVVQFKNQLGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C9</accession>
    <name>K9Z6C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219690.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1862"/>
    <dbReference type="EnsemblBacteria" id="AFZ53963">
        <property type="protein sequence ID" value="AFZ53963"/>
        <property type="gene ID" value="Cyan10605_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1862"/>
    <dbReference type="eggNOG" id="ENOG5033B15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195392_0_0_3"/>
    <dbReference type="OMA" id="DAPCHAG"/>
    <dbReference type="OrthoDB" id="1965987at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7773" checksum="9165BB511487B01D" modified="2013-03-06" version="1">MKKTLYIPDELWEELTNYLKQHPQENPSSVVQMALKEKLRPRNGEGLLKLAGIVKNAPKDASTNINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G5</accession>
    <name>K9Z6G5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2703"/>
    <dbReference type="EnsemblBacteria" id="AFZ54776">
        <property type="protein sequence ID" value="AFZ54776"/>
        <property type="gene ID" value="Cyan10605_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2703"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2868"/>
    <dbReference type="HOGENOM" id="CLU_1382123_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938687" evidence="1">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="21486" checksum="D723DF5B01570C3A" modified="2013-03-06" version="1" precursor="true">MNLKMFSSVSTLGLGILLSLVSLSPTKAEIQQNTSNKSKNNSSQLIITQLLGHQTYMGEPQIEWGDYLLGRVVGKSGGIMFIGLEDGTSFTAVGSVPPGSDVLVLKNADGSYSFVQGAKSEWISILESKYGYKRLDGSYVALNERTAALWKALETSSSSSIADLPPRQSTMVETQTMMEETEVMEYQETSQPIRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N4</accession>
    <name>K9Z6N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219788.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1968"/>
    <dbReference type="EnsemblBacteria" id="AFZ54063">
        <property type="protein sequence ID" value="AFZ54063"/>
        <property type="gene ID" value="Cyan10605_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1968"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2089"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_0_2_3"/>
    <dbReference type="OMA" id="GHTSFNW"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="32449" checksum="E4AF97ECC47DDBD8" modified="2013-03-06" version="1">MNIPSDWQKRTILGVGIICVSLAAIFVRLSQREINEVTVGFSLFIAAGRLIISTLLLIPSYGDLWTINKNHSSAVYYGLGAGICLGLHFATWISSLGFTSVAASVSLVTTNPLWVALLSWWCLGQKLTRKTIIGIAIAVLGSVLIAFAHGGNSFSSNPLLGAILALMGSWFASGYILLGTLAQQKGLTTKQYVTIAYFTGALCLLPLPPLFGTSYGGHSLNIYIYLILMAIISQIIGHTSLNWSLKYFSPTTISLLILFEPVISSLFAWWFFQEIPQLLVVIGALILLLGVTYSIKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q3</accession>
    <name>K9Z6Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ordered locus">Cyan10605_2143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219955.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2143"/>
    <dbReference type="EnsemblBacteria" id="AFZ54230">
        <property type="protein sequence ID" value="AFZ54230"/>
        <property type="gene ID" value="Cyan10605_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2143"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2278"/>
    <dbReference type="eggNOG" id="COG1859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_4_0_3"/>
    <dbReference type="OMA" id="YLYHGTV"/>
    <dbReference type="OrthoDB" id="1893705at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="21196" checksum="56070C76782059E1" modified="2013-03-06" version="1">MKKEHIKKSKILSLILRHQPEYIDIKLDEKGWVSINELLSGCEKKGIKISREEIEEIVKTNDKKRFTICKYTDKIKANQGHSIKVSLNLKCANPPDILYHGTTIKFTDSIIKQGLLKMNCHHVHLSSDIETAKKVGSRHGKVMILVIDTKKMTEDGYKFYLSENNIWLVDQVPSIYFSKIIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R6</accession>
    <name>K9Z6R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2819"/>
    <dbReference type="EnsemblBacteria" id="AFZ54886">
        <property type="protein sequence ID" value="AFZ54886"/>
        <property type="gene ID" value="Cyan10605_2819"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2819"/>
    <dbReference type="eggNOG" id="ENOG502Z7P6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042215_1_0_3"/>
    <dbReference type="OMA" id="CPGQWSF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="PTHR33835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="47127" checksum="93882241FFA7CE2A" modified="2013-03-06" version="1" precursor="true">MSKKREQKWGWWFLLPLYPYQQRATVRQEVVEDTIWTFEQPHGLLYAVVPIRMTVVKLKQGGLLVYCPIAPTPECVKLMRELEARYGEVKYIIHSTSSGLEHKIFVAPFARRFPQAQIWCAPSQWSFPLNLPLSWLGFPPQRTYILPEDWRETPFSDEFKYAMVNIDLSKGSFAEVALLHKSTETLLVTDAVIKIPPSPPAILELNPFPLLFHARETALDKLEDTPENRLKGWQRICLFALYFRPSMVDTAPLKQLLKEAFNAPNRSRENYFGAYPFRWQSGWKQSFDAIASLEKPFVAPILETLILPQNPSAAINWANNIASWQFKQIIPAHFSAPIQATPLEFRQAFSFLDIESNRPEKLYPSGNQQIFSRDSTFIKQLEATLIKLNIAKPPKLKRVQGEDNSSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U3</accession>
    <name>K9Z6U3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="8" type="ordered locus">Cyan10605_2844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220633.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2844"/>
    <dbReference type="EnsemblBacteria" id="AFZ54911">
        <property type="protein sequence ID" value="AFZ54911"/>
        <property type="gene ID" value="Cyan10605_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2844"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3023"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_3"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="41636" checksum="7642DC859DA8D7A6" modified="2013-03-06" version="1">MAESYLLEKLASVEMTFKELTRRLGDPDIATNPDELQKVAKMRSSLEETVMTYQEWQKAQEDLKGAREILKESKSDPEMQEMAQLEIEELENKLEELEQKLKILLLPKDPNDDKNIMLEIRAGTGGDEASIWAGDLVRMYSRYAEMMNWSVKLLSESLAEMGGFKEAILEITGESVYSKLKFEAGVHRVQRVPVTEAGGRVHTSTATVAVMPEVDEVEVQIDPKDIEMTTARSGGAGGQNVNKVETAVDLFHKPTGIRIFCTEERSQLKNRERAMQILRAKLYEIKLSEQQEAVTSMRRSQVGTGARSEKIRTYNYKDNRATDHRLGRNFDLSSVLEGKIDDVIQACIAQDQQERLEKMAASPTTAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W2</accession>
    <name>K9Z6W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220206.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2400"/>
    <dbReference type="EnsemblBacteria" id="AFZ54482">
        <property type="protein sequence ID" value="AFZ54482"/>
        <property type="gene ID" value="Cyan10605_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2400"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2546"/>
    <dbReference type="eggNOG" id="COG5493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081497_0_0_3"/>
    <dbReference type="OMA" id="ERECQAT"/>
    <dbReference type="OrthoDB" id="1511177at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="208" mass="23827" checksum="7776A696C79410B5" modified="2013-03-06" version="1">MTTTADDIWRILAELAEAQKKTKQLSQETERKFQRLSQESEQRFQESDRKFQQLIQETNRQISAVNKQISTLGGKWGRFVENMVAPACETIFLSRGIDVHQVSQRVRKRINSDTLEIDVLVTNQDSVLVIEVKSSLGVEDVKDLMADLKRFRLFFPEYNQKKLYGAVAGIEIEEGADKYADRQGLFVLSQKGETVGILNPPEFEAKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z749</accession>
    <name>K9Z749_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220119.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2311"/>
    <dbReference type="EnsemblBacteria" id="AFZ54395">
        <property type="protein sequence ID" value="AFZ54395"/>
        <property type="gene ID" value="Cyan10605_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2311"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2455"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348777_0_0_3"/>
    <dbReference type="OMA" id="NRIDETW"/>
    <dbReference type="OrthoDB" id="106788at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="5">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="795" mass="91067" checksum="81D839E63ACC7042" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z782</accession>
    <name>K9Z782_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220723.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2942"/>
    <dbReference type="EnsemblBacteria" id="AFZ55004">
        <property type="protein sequence ID" value="AFZ55004"/>
        <property type="gene ID" value="Cyan10605_2942"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2942"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3131"/>
    <dbReference type="eggNOG" id="COG3536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186686_1_0_3"/>
    <dbReference type="OMA" id="GLNDWHL"/>
    <dbReference type="OrthoDB" id="1965279at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019678">
        <property type="entry name" value="DUF2555"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10742">
        <property type="entry name" value="DUF2555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="8258" checksum="F4127883ACE43755" modified="2013-03-06" version="1">MTTLTLKEKDFAQITPEQVAEIAARLEEDEYNTPFEGLQDWHLLRAIAFHRQDLVEPYLYLLDIEAYDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B7</accession>
    <name>K9Z7B7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220810.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3032"/>
    <dbReference type="EnsemblBacteria" id="AFZ55091">
        <property type="protein sequence ID" value="AFZ55091"/>
        <property type="gene ID" value="Cyan10605_3032"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3032"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3230"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126005_2_1_3"/>
    <dbReference type="OMA" id="IDPDICH"/>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8500" checksum="597DA4DFEC07CFC9" modified="2013-03-06" version="1">MESIERITINPHICHGKPCIRGLRYPVEMILELLSAGMTTEEILLDYEDLELEDILAVLSFATKLTQVKSISLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B9</accession>
    <name>K9Z7B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2387"/>
    <dbReference type="EnsemblBacteria" id="AFZ54470">
        <property type="protein sequence ID" value="AFZ54470"/>
        <property type="gene ID" value="Cyan10605_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2387"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159580_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="26504" checksum="E1A3DF14E8C0D491" modified="2013-03-06" version="1">MENNSKLINTIIRFFTIGFLLAWCFILIRPFIIIILWAVIIAIALFPVFEWLKNRLGGRAKLSAISLALVGIAIVLGPISIIATVLFHNAQTIVEGIDTGTLVIPPPSPDIADIPIIGKPLSELWQLASLNLEALISQFKTQIVEFSKTLLLQATNISLILLKFIISIVVAVILTLNAKSLNQGVTLFVLRLAPTRGEEFIQLATTSTHCDYFTGGNWRNYCPRDSRFICRSCNLDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F0</accession>
    <name>K9Z7F0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220028.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2217"/>
    <dbReference type="EnsemblBacteria" id="AFZ54303">
        <property type="protein sequence ID" value="AFZ54303"/>
        <property type="gene ID" value="Cyan10605_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2217"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2356"/>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_3"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="30759" checksum="DDDEC022D8D9A9D2" modified="2013-03-06" version="1">MISSLKITILVENTAGGRGLLGEHGLSFLIEADNSRILFDTGQGMTLIHNGDILGVSLNNLDAIALSHGHYDHSGGLVHLLPLCKNTDLYLHPNALMPKYSPRGDIGFSLDEETLSRSFQCVIKTEKPTEIAKDIYITGSIPRNHPLEETGGLFWHDQNHHEVDPILDDQALYLDTYKGLFVILGCAHAGVINTLDYISQITNKKEIYGVIGGMHLLRASQERLMTTVETLKKYNIQLLGANHCTGIDAISFLWHELKSIDCRDCRVGTILEIESMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F9</accession>
    <name>K9Z7F9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220798.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3020"/>
    <dbReference type="EnsemblBacteria" id="AFZ55079">
        <property type="protein sequence ID" value="AFZ55079"/>
        <property type="gene ID" value="Cyan10605_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3020"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3218"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053941_0_0_3"/>
    <dbReference type="OMA" id="GCSVGMS"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="307" mass="35201" checksum="CE55A641B4645421" modified="2013-03-06" version="1">MTISATSPETTLSTKIINGLLAIKPLAEFAKNRARNMIIKRAYSIGVNWQENINSLQNHDWEQEINSLTNANISYPEYYLNSFHAYEKGNLQWEAAWELESAAYSVHSTIYSKTPQKEGDRTLRNNYHQVLKEKLAITPQNILDIGCGVGLSTFALKEQYPESKISGLDLSPYFLAVANYQSRQKNQNIQWLHSQAEKTNLPSNSHDLVSAFLIFHELPQLAAKNIIQEAHRVLKTGGYFSMMDMNPQSEVYKKMPRYVFTLLKSTEPYLDEYFSLNMESVFLDAGFEKPSIIPISIRHRTIIARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H7</accession>
    <name>K9Z7H7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220818.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3042"/>
    <dbReference type="EnsemblBacteria" id="AFZ55099">
        <property type="protein sequence ID" value="AFZ55099"/>
        <property type="gene ID" value="Cyan10605_3042"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3042"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3238"/>
    <dbReference type="eggNOG" id="ENOG5032YQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126046_0_0_3"/>
    <dbReference type="OMA" id="FGNIDYM"/>
    <dbReference type="OrthoDB" id="2062131at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14309" checksum="A9684BE2997DAA41" modified="2013-03-06" version="1">MAGLFGLFGRKNSNPQPSQPAQPKDAYFLDPDSAKTFGDIDYMRKSKTVRRTFPKTASNPSGGELVQEVSSTKMAKKNPNQFGGSNSSSNINSTPSTSNNTESSPSFSDQRRNTDTNMDMFRNMAKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L2</accession>
    <name>K9Z7L2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Photosystem II reaction center Psb28 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Photosystem II 13 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Photosystem II reaction center W protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psb28</name>
        <name evidence="6" type="ordered locus">Cyan10605_3082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the photosystem II complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the Psb28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220858.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3082"/>
    <dbReference type="EnsemblBacteria" id="AFZ55139">
        <property type="protein sequence ID" value="AFZ55139"/>
        <property type="gene ID" value="Cyan10605_3082"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3082"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3284"/>
    <dbReference type="eggNOG" id="ENOG5031GDS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137323_1_0_3"/>
    <dbReference type="OMA" id="EATYTWK"/>
    <dbReference type="OrthoDB" id="1995854at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01370">
        <property type="entry name" value="PSII_Psb28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038676">
        <property type="entry name" value="Psb28_c1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005610">
        <property type="entry name" value="PSII_Psb28_class-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34963">
        <property type="entry name" value="PTHR34963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03912">
        <property type="entry name" value="Psb28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03047">
        <property type="entry name" value="PS_II_psb28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="12680" checksum="64906887B61A2A15" modified="2013-03-06" version="1">MARIEFAQGVVEESIPDVRLTRSRDGSNGTATFRFESTKILDSGNTQEVTGMYLIDEEGELVTREVKCKFVNGEPTAIEAIYVIKNPEEWDRFMRFMERYAKENGLGFTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R4</accession>
    <name>K9Z7R4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220353.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2550"/>
    <dbReference type="EnsemblBacteria" id="AFZ54630">
        <property type="protein sequence ID" value="AFZ54630"/>
        <property type="gene ID" value="Cyan10605_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2550"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2707"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114024_0_0_3"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044241">
        <property type="entry name" value="TxlA/HCF164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353">
        <property type="entry name" value="PTHR47353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938624" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="22036" checksum="F05872878E256BE1" modified="2013-03-06" version="1" precursor="true">MKIRFFSFVSIVSLLSIASLTGCVNPNVSQTNSATETQEIQNNPCASKNPCAGKNPCAGKNPCAGKNPCAGKNPCAGKNPCASKNPCAGKAGTVGASLAQELQGKPVLVDVYASWCPACKNIALTLSQLEKDYADKVHFVVFDMSDKSTTAQAEAKAQELGLAKFLAENKTQTGMLTIIEPSTGVILAQHRNNPNIEDYQSVLDKAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S4</accession>
    <name>K9Z7S4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2709"/>
    <dbReference type="EnsemblBacteria" id="AFZ54782">
        <property type="protein sequence ID" value="AFZ54782"/>
        <property type="gene ID" value="Cyan10605_2709"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2709"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_4_0_3"/>
    <dbReference type="OMA" id="YIFKPTF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="23102" checksum="F3B47A8A625E73D5" modified="2013-03-06" version="1">MNNNGLPPQPISPVNEFFWALIGLMLTIFGTFVEVFFVIPTNTTNLENIDTTSLGITYQLAGVFFTGMVGGRNAAAYAQIAYVIMGLFKLPIFYQGGSFDYIQYPSFGYILGFIPGAWLCGFLVLPGKRRLELFTISAFLGLLVIHLFGILYLILYTYLTPFLGNQLTPTYLWDAINLYTITPFPSQLALICAISVVAFIIRLILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X6</accession>
    <name>K9Z7X6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="2">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220222.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2416"/>
    <dbReference type="EnsemblBacteria" id="AFZ54498">
        <property type="protein sequence ID" value="AFZ54498"/>
        <property type="gene ID" value="Cyan10605_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2416"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2560"/>
    <dbReference type="eggNOG" id="COG2821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037751_1_0_3"/>
    <dbReference type="OMA" id="DQNGHPY"/>
    <dbReference type="OrthoDB" id="1529555at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MltA" evidence="7">
        <location>
            <begin position="137"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="379" mass="43458" checksum="67CAF3DDAFD45322" modified="2013-03-06" version="1">MKKKQLYKIFLLTFIYNFIYPLFPSISYPLIQINNIPQNLIDEKLFTDDKQKLIQGINHSLSYLETTKAKEVYENYPLKEFSRERVIASLKRFRQLLISAKTPQQLQASVEREFVFYKSVGNDNQGRVDFTGYFQPLYPASRQKTDVFRYPLYRKPSNFDSWQTPHPSRKDLEGKDGLGNNSLIKGYELVWLRDRLQAYLVQVQGSAQLRLTDGTIMTIGYDGATDYPYTSLGKELINDGKIPAEEMSLPRLMAYLENNPDELEVYLPRNNRFIFFTETKGKPATGSLNVPVTDERSIATDKNLMPPGGLALIYTRIPQINQNKELITPMTARYVLDQDTGSAIKGAGRVDIYFGTGDIAKSKAGLVDWEGELYYLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z873</accession>
    <name>K9Z873_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221114.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3354"/>
    <dbReference type="EnsemblBacteria" id="AFZ55396">
        <property type="protein sequence ID" value="AFZ55396"/>
        <property type="gene ID" value="Cyan10605_3354"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3354"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3572"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_1_0_3"/>
    <dbReference type="OMA" id="QWFKVPP"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="457"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="879" mass="96851" checksum="2B7F349F72F7466A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A8</accession>
    <name>K9Z8A8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">clpB</name>
        <name evidence="14" type="ordered locus">Cyan10605_3342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221102.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3342"/>
    <dbReference type="EnsemblBacteria" id="AFZ55384">
        <property type="protein sequence ID" value="AFZ55384"/>
        <property type="gene ID" value="Cyan10605_3342"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3342"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3560"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_3"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="877" mass="99764" checksum="297C26337BB9AADB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G8</accession>
    <name>K9Z8G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220741.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55022">
        <property type="protein sequence ID" value="AFZ55022"/>
        <property type="gene ID" value="Cyan10605_2960"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2960"/>
    <dbReference type="HOGENOM" id="CLU_1465909_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="19557" checksum="9C1E7885F27B0034" modified="2013-03-06" version="1" precursor="true">MLCLSKIAGKYFLIVATSFSLISGTQNVLAESVNIRFTGTVTKQCYITVDSNGRLGENDSRTKLASELPNGESMKATLRCNAPTQIEISEPILSSEQDLNNPISISNLVINGCRTQQGMGSPVFAGNSASGYKSVANSGDFGWTPEQVSKCSNLIVNMSITNGGGEMLPMGNYAFDVRISTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H0</accession>
    <name>K9Z8H0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Photosystem II protein D1</fullName>
            <shortName evidence="16">PSII D1 protein</shortName>
            <ecNumber evidence="16">1.10.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Photosystem II Q(B) protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">psbA</name>
        <name evidence="19" type="ordered locus">Cyan10605_2588</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2</text>
            <dbReference type="Rhea" id="RHEA:36359"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.10.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="16">The D1/D2 heterodimer binds P680, chlorophylls that are the primary electron donor of PSII, and subsequent electron acceptors. It shares a non-heme iron and each subunit binds pheophytin, quinone, additional chlorophylls, carotenoids and lipids. D1 provides most of the ligands for the Mn4-Ca-O5 cluster of the oxygen-evolving complex (OEC). There is also a Cl(-1) ion associated with D1 and D2, which is required for oxygen evolution. The PSII complex binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cellular thylakoid membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="16">C-terminally processed by CtpA; processing is essential to allow assembly of the oxygen-evolving complex and thus photosynthetic growth.</text>
    </comment>
    <comment type="PTM">
        <text evidence="16">Tyr-160 forms a radical intermediate that is referred to as redox-active TyrZ, YZ or Y-Z.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Cyanobacteria usually contain more than 2 copies of the psbA gene.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="16">Herbicides such as atrazine, BNT, diuron or ioxynil bind in the Q(B) binding site and block subsequent electron transfer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16 17">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.9" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220386.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z8H0"/>
    <dbReference type="STRING" id="755178.Cyan10605_2588"/>
    <dbReference type="EnsemblBacteria" id="AFZ54663">
        <property type="protein sequence ID" value="AFZ54663"/>
        <property type="gene ID" value="Cyan10605_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2588"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2749"/>
    <dbReference type="eggNOG" id="ENOG502Z8GZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054206_1_0_3"/>
    <dbReference type="OMA" id="MHERNVH"/>
    <dbReference type="OrthoDB" id="382342at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010242">
        <property type="term" value="F:oxygen evolving activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009635">
        <property type="term" value="P:response to herbicide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01379">
        <property type="entry name" value="PSII_PsbA_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036854">
        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005867">
        <property type="entry name" value="PSII_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PTHR33149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00256">
        <property type="entry name" value="REACTNCENTRE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="SSF81483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01151">
        <property type="entry name" value="psbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="13 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 16" id="KW-0359">Herbicide resistance</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 16" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="16" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_5023319743" description="Photosystem II protein D1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5007347444" evidence="16">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Quinone (B)" evidence="16">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>ChlzD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[CaMn4O5] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:189552"/>
        </ligand>
        <ligandPart>
            <name>Mn</name>
            <dbReference type="ChEBI" id="CHEBI:18291"/>
            <label>1</label>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>PD1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>[CaMn4O5] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:189552"/>
        </ligand>
        <ligandPart>
            <name>Mn</name>
            <dbReference type="ChEBI" id="CHEBI:18291"/>
            <label>1</label>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="site" description="Tyrosine radical intermediate" evidence="16">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes free radical intermediate" evidence="16">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by CtpA" evidence="16">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ54663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="39185" checksum="6D8500A300862A49" modified="2013-03-06" version="1">MTTTIQSQQLSVWEQFCQWVTSTNNRLYIGWFGVLMIPTLLTATTCFIIAFIAAPPVDIDGIREPVAGALLYGNNIITASVVPSSNAIGLHFYPIWEAATLDEWLYNGGPYQLIIFHFLIGIYCYMGRQWELSYRLGMRPWICVAYSAPVSAATAVLLVYSIGQGSFSDGLPLGISGTFNFMFVLQAEHNVLMHPFHMLGVAGVFGGALFSAMHGSLVTSSLVRETTETESQNSGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLGAWPVIGIWFAALAVCCFAFNLNGFNFNHSILDSNGHVIKSWADVINYANIGIEVMHERNVHNFPLDLAGAEPISAPIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J3</accession>
    <name>K9Z8J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220396.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2598"/>
    <dbReference type="EnsemblBacteria" id="AFZ54673">
        <property type="protein sequence ID" value="AFZ54673"/>
        <property type="gene ID" value="Cyan10605_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2598"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_5_2_3"/>
    <dbReference type="OMA" id="HKAVVIH"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19652" checksum="77E1D94829942196" modified="2013-03-06" version="1">MSESPLSVAKPSSQNTTVFQQRFLKFVLLPDTNLMISLSEIAAVLKIPLGQIIPIPEMPSWVIGVYNWRGQIIWMVDLGQLLGFTPWYQQSVIASNHKAVVIHPSNQNLRNSASGDLIGLIVSDVNDIELCDTSDIHSPPASAVTPELAPFLRGYWIKNNGEIVVTVDADAIFAAMPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q5</accession>
    <name>K9Z8Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220456.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2659"/>
    <dbReference type="EnsemblBacteria" id="AFZ54733">
        <property type="protein sequence ID" value="AFZ54733"/>
        <property type="gene ID" value="Cyan10605_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2659"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739690_0_0_3"/>
    <dbReference type="OMA" id="WDFAVLY"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17577" checksum="B63C5F6D86AF2FED" modified="2013-03-06" version="1">MNNQNIDIKELQNLSQKIPEKMPYIKMVILFGSRARGDINDKSDWDFAILCDREIVAKTFKNKVSSWFAYSVNLNEIFDLKTERIDIIDLNSCSDFIAHYIARDGVLIYEKNEGEFEHFRREKLKTESQMNVISKNLRAEIEEFLSECGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R9</accession>
    <name>K9Z8R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220709.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2928"/>
    <dbReference type="EnsemblBacteria" id="AFZ54990">
        <property type="protein sequence ID" value="AFZ54990"/>
        <property type="gene ID" value="Cyan10605_2928"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2928"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3115"/>
    <dbReference type="eggNOG" id="ENOG5032S0B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152526_0_0_3"/>
    <dbReference type="OMA" id="WQIVRFG"/>
    <dbReference type="OrthoDB" id="2026167at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="14307" checksum="9C973B7885C6DB37" modified="2013-03-06" version="1">MSDSEKTPESATELNIEEAILQLEAQLEKVKQRHQQIINDKQRKEELINRKEQLKTLKAENNPPDSLKSELKYIEEELNEIEVRLESELFKWSSLSEPFWQIVRFGGIGIIIGWILKTMTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T0</accession>
    <name>K9Z8T0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220486.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2690"/>
    <dbReference type="EnsemblBacteria" id="AFZ54763">
        <property type="protein sequence ID" value="AFZ54763"/>
        <property type="gene ID" value="Cyan10605_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2690"/>
    <dbReference type="eggNOG" id="ENOG5032VR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123293_1_0_3"/>
    <dbReference type="OMA" id="PEIACDR"/>
    <dbReference type="OrthoDB" id="2018634at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4168" evidence="1">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="15882" checksum="7406D2045FD91F22" modified="2013-03-06" version="1">MKVGSQFFLVCGLAVFGVSLGIVPEYNQGSISIESKAMAQNVSDEDLKKYAQAAIEIENLRKTTYSNIEGIVGKSMGQMSCNQRQSFSQLPDNARNMAIEYCDQSETIVKNHGLSVNRFNQITQQVKQNPSLKQRLQSIIGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V6</accession>
    <name>K9Z8V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase heat domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220749.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2968"/>
    <dbReference type="EnsemblBacteria" id="AFZ55030">
        <property type="protein sequence ID" value="AFZ55030"/>
        <property type="gene ID" value="Cyan10605_2968"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2968"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052019_0_0_3"/>
    <dbReference type="OMA" id="DFQQRWE"/>
    <dbReference type="OrthoDB" id="800814at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="396" mass="44180" checksum="F3A87EF8DA7AA178" modified="2013-03-06" version="1">MSQTLESLTLETETGKINHYDISYILGSNDSISLETAIEILARGNFEAKWVVSKVLVRYGEKVIPLLKEIILDESADVELRCSALRIVQQIKSPQVIFVISELFSLTQSEELMALAIETLASQGKECVDFLSNLLNQEEYRIFATKALAQIPHTSIIAPLLSVTKDENSEVRLYSITALKNFDRASILKVMIEALEDNSSSVRKEALIGIGLRLKKTQEIPLISIIAPLLNDLNLGVAQQAAITLSKCSHPLAVNFLEKSLISPYTPIPLKITIIKSLAWIETEKSIQSLGNYLILADHLLTLEIIKVLGRVTNSKITQDAIALRHLVIAILNNFYENIPSSKNTPEILQSLCYSWKQLKAKSALKYVQEITGNSKKYFNSLEAEKTLFHLKSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X7</accession>
    <name>K9Z8X7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220774.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2995"/>
    <dbReference type="EnsemblBacteria" id="AFZ55055">
        <property type="protein sequence ID" value="AFZ55055"/>
        <property type="gene ID" value="Cyan10605_2995"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2995"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3191"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_3_3"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="26258" checksum="CECAF77C26490003" modified="2013-03-06" version="1">MNQNQLVKNLDEIRNTIPTSVRLVAVTKKVDVEVMKWVYEQGIKDFGENKLQEAINKQAQLQDLNDITWHFIGHLQSNKAKKAVESFAWIHSVDSLKIAQRLDFYAQQALNEKVIIKKPQVCLQVKPLPDDNKYGWTTEQLWNDLPLLQELHYLSVRGLMVILPLGLSQEETLSTFKSLKVLQEKIKDKGYFSDNFNQLSMGMSEDYLYAIEAGATMIRLGRVIFNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z924</accession>
    <name>K9Z924_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220824.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3048"/>
    <dbReference type="EnsemblBacteria" id="AFZ55105">
        <property type="protein sequence ID" value="AFZ55105"/>
        <property type="gene ID" value="Cyan10605_3048"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3048"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041608_0_0_3"/>
    <dbReference type="OMA" id="PPPGYNW"/>
    <dbReference type="OrthoDB" id="401909at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="400" mass="45893" checksum="6143EBA61A7B286D" modified="2013-03-06" version="1">MSELRKAVQELYNTYPFPPDPLLDEPPTGYNWRWHYQSAYNFCTGIKPDNDKIRILDAGCGTGSGTEYLILHNPYAEIIAIDISENALATAQKRLEKSGVLANFHGSITFKQLPIESAVTLEGHFDLINCVGVLHHLPDPKAGIKALGEKLAEGGIMHIFVYGELGRWEIQLMQKAIALLQNDKIGDYKDGVKVGREIFATLPENNRLVKREKERWQWENQRDECFADMYVHPCETDYNIDTLFDFIHSSSLEFIGFSNPDIWQIERLIGKNPDLMSRAENLNPIQRYRLIELLDPESITHYEFFLAKPPLPKYDWQDDELLGKAKPELNPCLYGWESKSLLDYQFKPVTIDDEEFTFMQYCAKNPTANLTVTDILGQTNFTLPQVRSLLSQQLIILSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9B8</accession>
    <name>K9Z9B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221040.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3276"/>
    <dbReference type="EnsemblBacteria" id="AFZ55322">
        <property type="protein sequence ID" value="AFZ55322"/>
        <property type="gene ID" value="Cyan10605_3276"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3276"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296970_0_0_3"/>
    <dbReference type="OMA" id="IYRFENI"/>
    <dbReference type="OrthoDB" id="123190at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="894" mass="100658" checksum="2E93C6A727E468E2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D3</accession>
    <name>K9Z9D3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ordered locus">Cyan10605_2941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220722.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2941"/>
    <dbReference type="EnsemblBacteria" id="AFZ55003">
        <property type="protein sequence ID" value="AFZ55003"/>
        <property type="gene ID" value="Cyan10605_2941"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2941"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3130"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_2_2_3"/>
    <dbReference type="OMA" id="LFNCNTP"/>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="22939" checksum="697BA7FAB08E8F12" modified="2013-03-06" version="1">MNIETLILAGGKSSRMGQDKALLKINNKPLLLNIYSIAKEISNRVSLITYNVEKYKKILPSDVVFISDSQPFQGALMAFAQGLKYVNSEWVFLLACDLPCLTLKEVKLWVSQLSQIPSEVMAFLPQNEKGWDCLCGFYRSSCYSSLNNYLQTNNRSFQRWLNEEKVRPIQVENQQVLFNCNTVQDYQSIGFSEKLGGNEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9M2</accession>
    <name>K9Z9M2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221140.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3380"/>
    <dbReference type="EnsemblBacteria" id="AFZ55422">
        <property type="protein sequence ID" value="AFZ55422"/>
        <property type="gene ID" value="Cyan10605_3380"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3380"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3598"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169009_0_0_3"/>
    <dbReference type="OMA" id="IAFRQNV"/>
    <dbReference type="OrthoDB" id="1864676at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="11467" checksum="FEE4098A98FF981A" modified="2013-03-06" version="1">MSTSSVPKKTAVLVVMIGETVLQDPIIKLLKDLGVNGYTLSQAQGAGRHGSRRGDMAGYNTNIEIRTIVSQELSEAIFSGLTEYQSNHALIAFRQNVEALSGFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9M6</accession>
    <name>K9Z9M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpxP/Spy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220802.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3024"/>
    <dbReference type="EnsemblBacteria" id="AFZ55083">
        <property type="protein sequence ID" value="AFZ55083"/>
        <property type="gene ID" value="Cyan10605_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3024"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3222"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123310_0_0_3"/>
    <dbReference type="OMA" id="WANMMAD"/>
    <dbReference type="OrthoDB" id="1993673at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09916">
        <property type="entry name" value="CpxP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012899">
        <property type="entry name" value="LTXXQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07813">
        <property type="entry name" value="LTXXQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="20063" checksum="795560362ECDB6A8" modified="2013-03-06" version="1" precursor="true">MNNLIRHSLIFVTIAGFGFTGNASASNYEQNLNVNSRLSVSTESSQIVAQKRWGDDDKEYKGEKLIERLNLTAEQRNQMTQIRNKYQPQFNSLREQIRTERNTLSQMMRNNQNESQLRSQHQKIVTLDQQIHNLRFESMLEMRAVLTPEQRQEWANMMADRKMSRQGQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S9</accession>
    <name>K9Z9S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221195.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3437"/>
    <dbReference type="EnsemblBacteria" id="AFZ55477">
        <property type="protein sequence ID" value="AFZ55477"/>
        <property type="gene ID" value="Cyan10605_3437"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3437"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3662"/>
    <dbReference type="eggNOG" id="ENOG50320CM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098316_0_0_3"/>
    <dbReference type="OMA" id="RLWLRDC"/>
    <dbReference type="OrthoDB" id="1966068at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="199" mass="23355" checksum="2C6F2E6857D1E838" modified="2013-03-06" version="1" precursor="true">MKLKYSFLLKFIFIFISGIWFYTPQILATEDKEIKSYSVLEKCNNNWENLTKSLTKDVADYGNRIIQSSRIYPNLDNFLPTYIVTASIPDTQSLPLNNFASEDFYMSENQETKQLFFTTLERQYSSNNRIIEAQNFHWLIFTFTPQGWQLVKAITRFGYPQPEGDFSVSPPRDTTNGIIGQAVNLWLRDCQHLRLIDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9X6</accession>
    <name>K9Z9X6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221240.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3487"/>
    <dbReference type="EnsemblBacteria" id="AFZ55522">
        <property type="protein sequence ID" value="AFZ55522"/>
        <property type="gene ID" value="Cyan10605_3487"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3487"/>
    <dbReference type="HOGENOM" id="CLU_2301143_0_0_3"/>
    <dbReference type="OrthoDB" id="2172038at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="11222" checksum="841556DFADFA25D4" modified="2013-03-06" version="1">MLNQDILGTKELFAESTQVVVKEEKVKMKSISNEEQEKDKSHPILIIGSNNVVGKNVFLINTGSDQETIQEALQIFPPEILDKFMFGLGTEIQKKSSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y1</accession>
    <name>K9Z9Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221245.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3492"/>
    <dbReference type="EnsemblBacteria" id="AFZ55527">
        <property type="protein sequence ID" value="AFZ55527"/>
        <property type="gene ID" value="Cyan10605_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3492"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_2_3"/>
    <dbReference type="OMA" id="RVWAVAN"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="253" mass="28428" checksum="A7B05E614A1CECBA" modified="2013-03-06" version="1">MKTNVIALFNQAGGVGKSTLTMNLGYALAKKKKKVLLLDLDPQASLTTFMGIEPHELDITVYDALVETFHLNIKNKIHGLDLAPTNINLSLAEMELVSALNREQRLKQVLFPILPNYDFILIDCPPSLGILSILALTAATHLLVPIETEFKSYFGTGLLLDTVARIRRHVNPDLDFAGFVPMKFDKRRSQHLRTYEQMKEELTKLGTVFTPIPDSTVFPDSTEERLPLALYKPKHPAVKVFNDIAKHLLQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA79</accession>
    <name>K9ZA79_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220986.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3221"/>
    <dbReference type="EnsemblBacteria" id="AFZ55268">
        <property type="protein sequence ID" value="AFZ55268"/>
        <property type="gene ID" value="Cyan10605_3221"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3221"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3434"/>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019562_1_1_3"/>
    <dbReference type="OMA" id="GFTMISS"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="177"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="478" mass="54646" checksum="A31E2608B2556F68" modified="2013-03-06" version="1" precursor="true">MKTLKTLLKFIKNNLSSSYRKITILFIFTLLLVIATPQTRQIIQAKAINGIEQRIKSQKMGIMENNFRNEYEEYFGRVINTEQFNPANIRITSSHNSGNASEIAQKIAIADRLAQTKSAVMWVVPEKEYLHLVLITSRGIITVRDLYEVPFDTINQTVIDFYQQINELETPFDLTLSQKLHQWIISPFEKEILEPEKIDNILFCLGEGVRLLPFGALHDGERFLVQKYNLSRIPAFDLINPEYKPLENPTVLAMGASNFTDNTPLPGVLIELQEVAQKIQQRSSQNQEEILFNQEFTLANMQQRLKEKPFEIIHLATHADFKPGSPNNSYIQFWDKKLTLDKMYELPWQTPPDLLILSACNTAVGDNNSELGFTGIALQSGVKSALGSLWYVSDLGTLALITEFYEQLINQPEKNPTKVQALTKAQNLLLEGKVYFEDNRLITPEGEIYLPDNLKLKGKLDLSHPFYWSAFTLISSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAE7</accession>
    <name>K9ZAE7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221280.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3532"/>
    <dbReference type="EnsemblBacteria" id="AFZ55565">
        <property type="protein sequence ID" value="AFZ55565"/>
        <property type="gene ID" value="Cyan10605_3532"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3532"/>
    <dbReference type="eggNOG" id="ENOG503347Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406384_0_0_3"/>
    <dbReference type="OrthoDB" id="2159182at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="676" mass="76055" checksum="3E27A1F62C6ED723" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ33</accession>
    <name>K9YZ33_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">Cyan10605_0025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217918.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0025"/>
    <dbReference type="EnsemblBacteria" id="AFZ52186">
        <property type="protein sequence ID" value="AFZ52186"/>
        <property type="gene ID" value="Cyan10605_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0025"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.27"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_3"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="416" mass="46807" checksum="634C04901AE21B87" modified="2013-03-06" version="1">MDSIQAIRGTKDILPEEIVYWQYLEKTAADILTKAAYREIRTPIFEQTNLFERGIGEATDVVGKEMYTFTDRGDRSLTLRPEGTAGVVRSYIQNKLFASGGVERLWYTGAMFRYERPQAGRQRQFHQIGLELLGSKSPRADVEVIAIATDILKALGLKNLSLQLNSVGNQEDRQKYRQALVDYLTPYKADLDPDSQDRLTRNPLRILDSKDQKTQEITENAPSILDHLGEDSRYHFEQVCGLLTELGIDYQLNARLVRGLDYYTHTAFEIQSADLGAQATVCGGGRYDGLISQLGGNETPAIGWAMGMERLILLLQNLNPLTPQCPDIYFVSRGEKAENQALIMAQKLRHNDFNVELDLSGSNFGKQFKRGDRSGAKICLILGDEEVENKTVQIKHLVTGEQKTVSQDELINVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZG8</accession>
    <name>K9YZG8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218041.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0152"/>
    <dbReference type="EnsemblBacteria" id="AFZ52309">
        <property type="protein sequence ID" value="AFZ52309"/>
        <property type="gene ID" value="Cyan10605_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0152"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.158"/>
    <dbReference type="eggNOG" id="ENOG5034AB3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186123_0_0_3"/>
    <dbReference type="OMA" id="REWAYFE"/>
    <dbReference type="OrthoDB" id="2024458at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025477">
        <property type="entry name" value="DUF4327"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14217">
        <property type="entry name" value="DUF4327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8375" checksum="8F2E3CB5133956D0" modified="2013-03-06" version="1">MSVKTIYSVGIIKQKAKELVSKGLISRQQPIYTLCNFIPAGEWHTIEIELEFNGYLLRDHIIDLIQPETWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZP0</accession>
    <name>K9YZP0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218148.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0266"/>
    <dbReference type="EnsemblBacteria" id="AFZ52416">
        <property type="protein sequence ID" value="AFZ52416"/>
        <property type="gene ID" value="Cyan10605_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0266"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.276"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_3"/>
    <dbReference type="OMA" id="CGTWAWG"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="334" mass="37555" checksum="3D06B36AE8C3C519" modified="2013-03-06" version="1">MNFIIESKIKVAENLHLSPMGCGTWAWGNRFLWGYEPEMDTQLQETFNLLVSQGVTWFDTGDSYGTGKLNGRSETLLGKFSREYQGDHQSEIAIATKLAVYPWRLTPQSMINACEKSAQRLGRKVDLVQLHWSPAKYLPWQEKPLLEGLARLSNQGLVKAVGLSNYGAKNLLSAYEFFRERGVKISTLQVQYSLLSTYPFVKLRLKELCQQLDIKIIAYSPLTLGLLTGKYRDLNHLPSGARRGLFKQLLPAIKPLLLTLDAIASDNGKTMAQTAINWCICKGTIPIPGAKNPLQARENLGALGWRLSRGEVEELERVALGLNKQMIQNIFQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZX8</accession>
    <name>K9YZX8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218201.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0321"/>
    <dbReference type="EnsemblBacteria" id="AFZ52469">
        <property type="protein sequence ID" value="AFZ52469"/>
        <property type="gene ID" value="Cyan10605_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0321"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051659_0_0_3"/>
    <dbReference type="OMA" id="PGGIWHF"/>
    <dbReference type="OrthoDB" id="1473120at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="34477" checksum="D801E60FF2DB2908" modified="2013-03-06" version="1" precursor="true">MKLLKQFLRYFIFGITLFFLATTIVNNWRSITSIEFNKYLFLLIFISLILNSFAHIFSAWVWTWILTLFNCKLGGFSAVKIYLITNISKYIPGNIWHFVGRVKAIQNHGDSIALGTFPVVLEPLLMAIASLLITIFSVSLGILEVNFSPLIFSLLLFFILIILIVIHPKFINPVLKKLVINKGKVETNIKLNKYPFLPLIGELIFLLLRGSAFMALMMPFIDLNIILIPQVLTAFSFAWLIGLIVPGAPGGLGIFEAVAIASLDPAIFPRDKIIIVVALFRFSSIIAETFTAYLAWLLYSVIVNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M9</accession>
    <name>K9Z0M9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218435.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0563"/>
    <dbReference type="EnsemblBacteria" id="AFZ52704">
        <property type="protein sequence ID" value="AFZ52704"/>
        <property type="gene ID" value="Cyan10605_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0563"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.594"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_2_3"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="23200" checksum="0EF0F8A759004910" modified="2013-03-06" version="1">MLDRWLSVLQKNRLIAVIRCNNLELGKKQAHAMAKAGVKLIEVTGNSYQPLELISTLRDELPSCYIGAGTILSHDFLTNAIASGIQFCFTPHFDPDLLALAHYHNIPMIPGALSPTEIITAFNYGAKTVKVFPIQSVGGVTYLKNILAPLPHIPLIPTGGVNISNAVDYIKAGAIAIGLASDLFPTDLIMEDNWQEITNRTKKLLENLEKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N4</accession>
    <name>K9Z0N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218019.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0130"/>
    <dbReference type="EnsemblBacteria" id="AFZ52287">
        <property type="protein sequence ID" value="AFZ52287"/>
        <property type="gene ID" value="Cyan10605_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0130"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.132"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050934_0_1_3"/>
    <dbReference type="OMA" id="SRHKGKF"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="35180" checksum="CFF8717EFD0CFCED" modified="2013-03-06" version="1">MRILIMGGTRFIGVSLTKILVAQGHEVVLFNRGNKPAPVNGIEQIHGDRTNASELKDKLAGQKFDAIFDNNGRELKDTKPLVELFKDQISHFVYVSSAGVYLPSEQMPHREDDPVDPQSRHKGKYETETYLKAEGVPFTSIRPTYIYGSGNYNDLEAWFFDRILRNQPILIPYHGLHFTQFGHVEDLATAMSLVLGNSQAVGQIYNISGDRYVTFKGLALACAEAVGKNPEEIEIKYYDPAQFNLEKRKAFPIRVQHFFADISKAQKELNWQPKYDLISGLKESFENDYLANGRDKVDVDFSLDQEILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S0</accession>
    <name>K9Z0S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218522.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0652"/>
    <dbReference type="EnsemblBacteria" id="AFZ52791">
        <property type="protein sequence ID" value="AFZ52791"/>
        <property type="gene ID" value="Cyan10605_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0652"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.688"/>
    <dbReference type="eggNOG" id="ENOG50324PR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119035_0_0_3"/>
    <dbReference type="OMA" id="YLIRRQW"/>
    <dbReference type="OrthoDB" id="1731653at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17339" checksum="78DA1D7AB6BA5379" modified="2013-03-06" version="1">MNGTECDRIQENSLEQFLKHKQLLVINPRKKNGLILIKTYYAEFAGPGAIIGGCFDQDLVNAIPVGNLSLIQASNFQERQRAYLIRRQWVKLIKQITDNPIPRQRAQVILNQFEHWFDSETAEKVSDEVFASIVGVFPETIKKARDLVNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V5</accession>
    <name>K9Z0V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein HSR1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0695"/>
    <dbReference type="EnsemblBacteria" id="AFZ52831">
        <property type="protein sequence ID" value="AFZ52831"/>
        <property type="gene ID" value="Cyan10605_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0695"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.728"/>
    <dbReference type="eggNOG" id="COG3596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028661_0_0_3"/>
    <dbReference type="OMA" id="NAWAFGH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="314"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="655" mass="75399" checksum="2D1A2B10C7FE0608" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X7</accession>
    <name>K9Z0X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218587.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0721"/>
    <dbReference type="EnsemblBacteria" id="AFZ52856">
        <property type="protein sequence ID" value="AFZ52856"/>
        <property type="gene ID" value="Cyan10605_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0721"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.756"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_5_3_3"/>
    <dbReference type="OMA" id="IVVACEL"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="14597" checksum="834202336F819E64" modified="2013-03-06" version="1">MYLLDTCVISDFVKGEKGTLEKIKNSSPQEIAVSSITVMEINHGLSINPQKAKKISPIIEELLKSITILDFSTKEAYITAQIRAFLRENGTPIGAYDVLIGATALSAGLILVTANTREFQRIADLKIINWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z9</accession>
    <name>K9Z0Z9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218607.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0743"/>
    <dbReference type="EnsemblBacteria" id="AFZ52876">
        <property type="protein sequence ID" value="AFZ52876"/>
        <property type="gene ID" value="Cyan10605_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0743"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.780"/>
    <dbReference type="eggNOG" id="ENOG502ZY99">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081117_2_0_3"/>
    <dbReference type="OMA" id="DGQVWEK"/>
    <dbReference type="OrthoDB" id="1751945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009631">
        <property type="entry name" value="CGLD27-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34214">
        <property type="entry name" value="PTHR34214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06799">
        <property type="entry name" value="DUF1230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="19992" checksum="CDF062984CE00BD3" modified="2013-03-06" version="1">MNQSPTNFCPVPVEQQPINEYQELKESWFFSWVTLSKWEFARKLFWIWLWSLLISSPIAAASFPPQKMTLIFLIASGLGSSLFVAFTLIRLYLGWAYIGDRLKKTKIVYEESSWYDGQVWEKPVEFYYRDQLIFKHQVEPMIKRLQKTGVTLASLMSISFVSLLLIQNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z185</accession>
    <name>K9Z185_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">Cyan10605_0834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218697.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0834"/>
    <dbReference type="EnsemblBacteria" id="AFZ52966">
        <property type="protein sequence ID" value="AFZ52966"/>
        <property type="gene ID" value="Cyan10605_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0834"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.877"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_3"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17746" checksum="5B804FEBB3C8A5B7" modified="2013-03-06" version="1">MIAIYPGSFDPITLGHLDLIKRSSILFEKVIVAVLKNPNKKPLFSIEKRVQQITECVNNISNVEVDSFTGLTVEYAKKKQAGVLLRGLRVMSDFEQELQMAHINKTLENSLETVFLATNTELSFISSSVVKEIAKFGGEIEHLVPPNIAEDLRIYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D4</accession>
    <name>K9Z1D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217900.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0007"/>
    <dbReference type="EnsemblBacteria" id="AFZ52168">
        <property type="protein sequence ID" value="AFZ52168"/>
        <property type="gene ID" value="Cyan10605_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0007"/>
    <dbReference type="eggNOG" id="ENOG50338XG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166136_0_0_3"/>
    <dbReference type="OMA" id="LMHRANL"/>
    <dbReference type="OrthoDB" id="2088278at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938551" evidence="2">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13000" checksum="B6B2B5971A67BCBE" modified="2013-03-06" version="1" precursor="true">MIINKNKTLAISFAFIALASFFAPANAQSNNINGKNEPFQSNERNPFYGDGINPLDIIHNANFFNSRSGSDFAEDTENNINSEAENFKQLQQKRILEMQQQKQTPSQEVETNTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I6</accession>
    <name>K9Z1I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0899"/>
    <dbReference type="EnsemblBacteria" id="AFZ53029">
        <property type="protein sequence ID" value="AFZ53029"/>
        <property type="gene ID" value="Cyan10605_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0899"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.944"/>
    <dbReference type="eggNOG" id="ENOG5032YID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204045_0_0_3"/>
    <dbReference type="OMA" id="FWAAVQD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="6795" checksum="BE0E666114855068" modified="2013-03-06" version="1" precursor="true">MYMTPKSGVLLLLSCIAAIASVGCVFELSSGVPQLGTTSTTVILAVSIPLTLITFILAVKDARANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L4</accession>
    <name>K9Z1L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEKHLA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218785.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0924"/>
    <dbReference type="EnsemblBacteria" id="AFZ53054">
        <property type="protein sequence ID" value="AFZ53054"/>
        <property type="gene ID" value="Cyan10605_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0924"/>
    <dbReference type="eggNOG" id="ENOG5032SCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115296_1_0_3"/>
    <dbReference type="OMA" id="IFNYGNQ"/>
    <dbReference type="OrthoDB" id="1728677at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013978">
        <property type="entry name" value="MEKHLA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08670">
        <property type="entry name" value="MEKHLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEKHLA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18289" checksum="D563C275C467E6F4" modified="2013-03-06" version="1">MDNQIWEKPEIISWTQILLNSYKSLLNKELIERNEDLLTDSKNLYNADFVVLSHNNKPDPIYNYGNQQALDLWEMNWQQLIQTPSRNTTEPISREEREALLKEANLKGYITNYGGVRVSSTGKRYLIQDITLWNLFDSNGEYCGQAATFSHWQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M5</accession>
    <name>K9Z1M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S13 D-Ala-D-Ala carboxypeptidase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218212.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0333"/>
    <dbReference type="EnsemblBacteria" id="AFZ52480">
        <property type="protein sequence ID" value="AFZ52480"/>
        <property type="gene ID" value="Cyan10605_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0333"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.348"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047821_0_0_3"/>
    <dbReference type="OMA" id="DPLFVWE"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="414" mass="46322" checksum="00A24875B1987A0D" modified="2013-03-06" version="1">MFIADLFAFLFFKSPQSDSFPVIRWHEAKIFQIQTQSDPQVQIIVDQYLNNLANQGLIKDQQGVWIQSNWSIEADNRGKIPAPAASLTKVATTIASLQTWDLDHRFVTNIFTTGKINNGTLEGDLIVEAGGDPLFVWEEAIALANRLQDLGINNITGDLILVGNWQMNYQENPLKSGEMLKQAFNSDNWSYVIEKQYQEIQNFQKRPKISIQGGVKVFSQKPDHSQLILTHQSLTLREILRLMNVYSNNKIAESLAQQIGGGEKIAQIVSQVANVPQEEILLQNGSGLGVDNRISPRAVARMFMALDTLLEKTNYNLGDLFPVSGVDNKGTIEARNIPFGIPCKTGSLAVVSALAGVIQTSEREKVYFAIVNYGNGLDNLRNQQDVLLQNLHNHWTIEPLKPNSDIEVKFGYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R5</accession>
    <name>K9Z1R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylglucosamine 6-phosphate deacetylase</fullName>
            <ecNumber evidence="5">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218877.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1020"/>
    <dbReference type="EnsemblBacteria" id="AFZ53146">
        <property type="protein sequence ID" value="AFZ53146"/>
        <property type="gene ID" value="Cyan10605_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1020"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1081"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_0_3"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="42214" checksum="1800AA049486A867" modified="2013-03-06" version="1">MTSTKTSFIITNGRLVGYSDLQTLVIENGNIKSIQPSHFKTNSDLDLEGDYLSLGGFDLQINGGLGLAFPDLCFDDIDKLHDICAYLWSTGVDQFLPTIVTTSVEKIHQSLKVIQEFKREKPRKNEAEIIGVHLEGPFLNYEKRGAHPPEYLLPLTLDNIKIVLGAYADVVKIITLAPELDEKKEVIPYLQSLGIVISLGHSQATAEDAIIAFQQGASMVTHAFNAMPNLHHRQAGLLGEAIVNPHVYCGLIADGNHVCPTMLKLILQASNYHQGVFVVSDALAPIGLGDGVYPWDSRTIEVKNGTARLPDGTLSGTTLPLFVGVQNLYEWGICNIEDAIALVTDAPRKALNMPCLEVSSPANLIRWHEDKQNKKLHWQRIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W1</accession>
    <name>K9Z1W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase alpha chain</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218100.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0213"/>
    <dbReference type="EnsemblBacteria" id="AFZ52368">
        <property type="protein sequence ID" value="AFZ52368"/>
        <property type="gene ID" value="Cyan10605_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0213"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.223"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_3"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="99"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="25136" checksum="DF69142F152E6334" modified="2013-03-06" version="1">MFTGLVQGVGKIRSLENDLYQIDIDSQAQHLICHDLEIGDSVAVDGICLTVEKILQGGFTATASPETLQRTTLGKSTIKQKKVNLETSLRVGGKIGGHFVSGHVDGIGCLIESVNKQQSWEMTFSFPSELKKQWQEYIAPYIVSKASIAVNGISLTIARCDSQSGEWFTVAVIPHTYAQTNLSLLQAGDWVNLESDILGKYVDRLISHRLGKLPQEDISLDFLATHGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X8</accession>
    <name>K9Z1X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ordered locus">Cyan10605_0453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218326.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0453"/>
    <dbReference type="EnsemblBacteria" id="AFZ52595">
        <property type="protein sequence ID" value="AFZ52595"/>
        <property type="gene ID" value="Cyan10605_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0453"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.479"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_3"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="239"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="249"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="268"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="52369" checksum="563EEFE43BF22F3C" modified="2013-03-06" version="1">MIEVKSYRDLTVWQKSQKIVQQETIVAIASAVVPSQGSIGVVRLSGQTALEIAKRIFHPQGKKQWESHRILYGYIKHPDHNTIIDEALLLPMFSPRSYTREDVIEFHCHGGIMPVQQVLELCLEQGARLANSGEFTLRAFLNGRIDLTQAESIAEIVGAKSVEASTVALASLRGKLAQPIKNIRHTLLDILAEVEARIDFEDDLPPLDEDQVKQNLQASLEQIKQILATKDQGELLRSGIKVAIVGQPNVGKSSLLNAWSRCDRAIVTDLPGTTRDVVESQLVVKGIPIQVLDTAGIRNTEDTVEKIGVERSLQAVNQADLILFTIDASQGWTEKETEIYEKIKGLNIILVINKTDLGNPDTINYPSEIKQIVNTAAAKNEGIEALESAIINTIEKGKTTARNLDIAINQRQAAALTRAKLALTQVEETIKNQLPLDFWTIDLRTAIQALGEITGEEVTESVLDRIFSRFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z215</accession>
    <name>K9Z215_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0284"/>
    <dbReference type="EnsemblBacteria" id="AFZ52433">
        <property type="protein sequence ID" value="AFZ52433"/>
        <property type="gene ID" value="Cyan10605_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0284"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_3"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13796" checksum="65E9910E295286F3" modified="2013-03-06" version="1">MPSREFELRIQDMLTEIEVVEDTVKDLNFETFAQNQQALRVILYGLAVIGEAVAKTIDELETQDSNIPWRQIRGLRNMVIHEYFRVDLVLIWQTIQEDLPMLKESLLHIQNNLRDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z221</accession>
    <name>K9Z221_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218967.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1114"/>
    <dbReference type="EnsemblBacteria" id="AFZ53236">
        <property type="protein sequence ID" value="AFZ53236"/>
        <property type="gene ID" value="Cyan10605_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1114"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1178"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_1_3"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="393" mass="43464" checksum="F00A94619488FAED" modified="2013-03-06" version="1">MAYKPLTLSTPKPVLSWAGHDLASQEMQMAKNVASLPFVFKHVALMPDVHLGKGALVGSVIATKDAIIPAAVGVDIGCGMCAIKTPFQANQLEGKLKKIRQEIEAIIPVGFNENKEVETKVTNWQGWRNFSDLHSGVQRLETKALKQMGSLGGGNHFIELCLDTDEQVWLMLHSGSRHIGNKLAECHIHTGKELAKLAGLKLPDPDLAYFVANTPEFDAYWRDLQWAQNYARFNRDVMMSRFKGIVEKYLAGGKPCKPLLKVNCHHNYAEKEIHFGEDVYVTRKGAVRATQEDYGIIPGSMGAKSFIVKGKSNHDSFCSCSHGAGRKMSRAKAKKEFDVADLIQQTEGIECRKDSGVIDEIPSAYKPIEEVMNQQTDLVEIVATLKQVICVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z234</accession>
    <name>K9Z234_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ordered locus">Cyan10605_1129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218980.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1129"/>
    <dbReference type="EnsemblBacteria" id="AFZ53251">
        <property type="protein sequence ID" value="AFZ53251"/>
        <property type="gene ID" value="Cyan10605_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1129"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1196"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_3"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="353"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="479" mass="54991" checksum="AE89F8963107D952" modified="2013-03-06" version="1">MSLTLYNTLTKQEEEFKPSNPERVTMYCCGITAYDYCHLGHARTCIIWDVVRRYLTWRGYKVKYIQNFTDIDDKILNRAKAENTTMEEVAERFIQAYFEDMEKLNVQKADSYPRATHTLDGIKRLIWELEEKGFAYEAQGDVYYSVSKFQSYGKLSGRNLDDLQAGASGRVNIQDQIKQESSDFALWKSAKPDEPSFESPWGKGRPGWHIECSAMVRDNLGETIDIHVGGSDLIFPHHENEIAQSEAVTGKPLARYWLHNGMVKVEGEKMSKSLGNFITIRDLLAKYDPMAVRLFILQANYRKPLDFTDGAMEAATNGWHTLMEGLNFGYKYGKDLDWTLEGHIQEIPSVKDDFSQAVDQDFNFASGLAVLFELAKELRKEGNLLSHEGRISQNSEDLERKWHTLVNLAQVLGLEAKFDQSLSVYSQISDQEIEDLISQRTIARQNKNYQESDRIRDLLKEKGVTLVDVGKGETKWHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z263</accession>
    <name>K9Z263_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease, type II, ApaLI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219015.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1164"/>
    <dbReference type="EnsemblBacteria" id="AFZ53286">
        <property type="protein sequence ID" value="AFZ53286"/>
        <property type="gene ID" value="Cyan10605_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1164"/>
    <dbReference type="HOGENOM" id="CLU_210481_0_0_3"/>
    <dbReference type="OrthoDB" id="1523050at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019036">
        <property type="entry name" value="Restrct_endonuc_II_ApaLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09499">
        <property type="entry name" value="RE_ApaLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7347" checksum="A7852D5E0A4B0D14" modified="2013-03-06" version="1">MFYYPQREQAIKIQQTLETVYKGVNGEYYAGEQAWNFIRNRTGFDLKQILIDIADQKTPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A5</accession>
    <name>K9Z2A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219003.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53274">
        <property type="protein sequence ID" value="AFZ53274"/>
        <property type="gene ID" value="Cyan10605_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1152"/>
    <dbReference type="eggNOG" id="ENOG50338GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12604" checksum="A70E5108B6B2C86F" modified="2013-03-06" version="1">MSQEAVIEFFEAVSQNEQLQERLMNIIESSENDREDVATFASESGYEITADELWAEIQKRQADFSQRQEAGELSDEELEAVAGGEFVATAMSIFAVTAFTAGQTILLTTKVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F2</accession>
    <name>K9Z2F2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218294.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0419"/>
    <dbReference type="EnsemblBacteria" id="AFZ52563">
        <property type="protein sequence ID" value="AFZ52563"/>
        <property type="gene ID" value="Cyan10605_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0419"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.443"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_3"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03138">
        <property type="entry name" value="GUFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027518">
        <property type="entry name" value="GUFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="602" mass="67294" checksum="C8D41550837D8A56" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H1</accession>
    <name>K9Z2H1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218491.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0621"/>
    <dbReference type="EnsemblBacteria" id="AFZ52760">
        <property type="protein sequence ID" value="AFZ52760"/>
        <property type="gene ID" value="Cyan10605_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0621"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.655"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_0_3"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="45513" checksum="B8EF788661ABF75A" modified="2013-03-06" version="1">MSINSAYLHIPFCRRRCFYCDFPITVLGDNGGNTYSNWQKEYVDFICQEIIVTSKCSNRPLDTVFFGGGTPSLLALEGLETILNTLNNCFGINQKAEISLEIDPATFNLEKLKSYKKLGINRISLGIQAFQDNLLEFSGRTHRVKDIYEGVEWINVADFENWSLDLISGLPYQTLNDWLDSLEKAIALSPKHISCYDLVLEPTTVFGKKYQEGDNPLPMDEITAQMYRLASEKLGLHFYEHYEISNYAQKGYECRHNQVYWLNQSYYGFGMGAASYVNNIRFTRPRTRQEYFKWVEQLKANQGKIEAIVTSKNEQILETLMLGLRLKKGVNLSELKSQFGEYIETKIIDCLKNHIETNLVIFDPHTLQLRLSDPDGFLYSNQVLTALFREFDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L1</accession>
    <name>K9Z2L1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218698.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0835"/>
    <dbReference type="EnsemblBacteria" id="AFZ52967">
        <property type="protein sequence ID" value="AFZ52967"/>
        <property type="gene ID" value="Cyan10605_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0835"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_3_3"/>
    <dbReference type="OMA" id="NFEAPWC"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12853" checksum="61BEA9DEA1933392" modified="2013-03-06" version="1">MISVNQDTFNQQVLESSQTVLVNFWAPWCGLCMMLNPILSQLESQWEGELKIASINADDNLQLANTHRLKNLPTLILYNKGRIIHRFEGFHSREDLYSTVNNIMLSFVPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M0</accession>
    <name>K9Z2M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218354.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0481"/>
    <dbReference type="EnsemblBacteria" id="AFZ52623">
        <property type="protein sequence ID" value="AFZ52623"/>
        <property type="gene ID" value="Cyan10605_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0481"/>
    <dbReference type="eggNOG" id="COG3240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582304_0_0_3"/>
    <dbReference type="OMA" id="TTANSWD"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="51716" checksum="BC22FA1D980346B7" modified="2013-03-06" version="1">MTVIFFGDSLFDIGNLTTLATPFGVELYPAPFYNDGKASNGQVLSEAIAARIGVDVESLIPYSSPTSPLNPLEENIVYAIAGATTGVFGSAGLNLQDFSIGLASQIQIFLENLPSNNTNAETIEVFITAGSNDILEILANPNFANIFITPENDDNEALINNTVNNIVNNISQGIYSIENQTGDIFVVGVSPLGDIPFALQIDQQIDNNIPLDLAGQTNQLLNTIAQQVNQELINIFDNPLNDVANVTIIDGFEVFTNAVNNRQNDLESPLINQISYQNYLAGNTGLGENLTVEDFFFLDGSHPTSVSNDYLADEIISQISESKLDTPIYRFQNRNIEGAYLYVGEEERQSVLANYPDFVEEGLAFNVADESDDELMPIYRFQNLNLQGAYLYVGEEERQNILENNSNFVEEGIAFYVYGVNSNQADSIYRFQNQNTPGAYLYVGETERQDILANYSNFQEEGIAFEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q8</accession>
    <name>K9Z2Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219220.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1378"/>
    <dbReference type="EnsemblBacteria" id="AFZ53491">
        <property type="protein sequence ID" value="AFZ53491"/>
        <property type="gene ID" value="Cyan10605_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1378"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1456"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_3"/>
    <dbReference type="OMA" id="HEFTWDF"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28686" checksum="E35E34A8EFA35359" modified="2013-03-06" version="1">MLNECVIKLKNIHVSYGKNLVLENINLEVKEKDFIGVIGPNGGGKTTLLKTLLGLIKPQQGEISIMNYPLNKGRKYIGYVPQALEFDRTFPIFVEDVVRMGRLSTKHLFKPYNHQDEEIVNHCLQQVGMAKLRSRPIGELSGGERQRVYIARALATKPSILLLDEPTANVDSRVQNNIYELLRELNEYMTILLISHDLAAISSYVKTIACLNRRLHYHQDKLITPEMIQATYQCPVDLIAHGIPHRVLPKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S0</accession>
    <name>K9Z2S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218753.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0892"/>
    <dbReference type="EnsemblBacteria" id="AFZ53022">
        <property type="protein sequence ID" value="AFZ53022"/>
        <property type="gene ID" value="Cyan10605_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0892"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.937"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064696_0_0_3"/>
    <dbReference type="OMA" id="HTYISGH"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="60"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="386" mass="44743" checksum="AD32ABEDC65694F3" modified="2013-03-06" version="1">MNNKKFITILIATIFTCILSYFINDFIFFKSVQGQENISFQTQELINKYQPFKPEKKDVRILVISDLNSAYGSTEYDDEVHLALKMLPFWQPDLILCSGDMIAGQKPSLTQAQIRAMWKAFDTQIAQPIRNLNIPFGFTIGNHDASSAIAPNNKFLFQQERDLAVEYWQNPKHNSGVKFLDRNQFPFYYTFEEDNIFFLVWDGSSSRIPKDKLSWVEKSLASEKAQQAKMRIIIGHLPLYAVSEGRDYPGEVLNNADELRQLLEKYDVHTYISGHHHAYYPAHKGELQLLHTGALGSGARPYLDNNIPPRKTITVVDVDFNNPDYTIYTTYDMQDFSLIKYEQLPRLIMGHNGMILRRDISIQNLTEEEKRICLNKFQDKKKCNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T4</accession>
    <name>K9Z2T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218768.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0907"/>
    <dbReference type="EnsemblBacteria" id="AFZ53037">
        <property type="protein sequence ID" value="AFZ53037"/>
        <property type="gene ID" value="Cyan10605_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0907"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.953"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_3"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20809" checksum="C913364F3BD26BD9" modified="2013-03-06" version="1">MRIYGNREIKTLSGKDTRPTTAKVREALFNIWCDRILDATWLDLCAGNGTMGAEALCRGVKEVVGIEKSSSACQIIRENWQKVANNEQNFRVLRGDVLKRLKNLQGKKFDCIYFDPPYELDIYNTVLDLILEYELLAKNGQIAVEYDPKKSIIKQKQNLDLLQTKIYGNTALNFYSNLPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y8</accession>
    <name>K9Z2Y8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dnaK</name>
        <name evidence="11" type="ordered locus">Cyan10605_1465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219305.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1465"/>
    <dbReference type="EnsemblBacteria" id="AFZ53576">
        <property type="protein sequence ID" value="AFZ53576"/>
        <property type="gene ID" value="Cyan10605_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1465"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1554"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_3"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="634" mass="68013" checksum="CB27C7F6AAA4EAB4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z335</accession>
    <name>K9Z335_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe(3+)-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218499.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0629"/>
    <dbReference type="EnsemblBacteria" id="AFZ52768">
        <property type="protein sequence ID" value="AFZ52768"/>
        <property type="gene ID" value="Cyan10605_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0629"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.663"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="33415" checksum="695FE265C5EE6EA4" modified="2013-03-06" version="1">MLEINQLTKFYESKKVLDSLNLNINKGEICGLLGANGAGKTTTINIICGLLNYEQGSIFINGQKLSKKSKYYLGVSPQENLLYSHLTCVENLAFFGKLYGLKGTKLKSSIYECLKAVNLLDKKDDTVSALSGGMQRKLNIAIALVHHPLLLILDEPTTGLDIEARYDIWQLILRLKQEGMTILLTTHLLDEAEKLCDRLCIIKQGKIVKEGSLNDLKNILPAKELIFIKCEQEEKLIEIAKKQGFNYRYYQGEIAILSEEILELSTIIDIFSEIYLTSVTKVNINLQHIYLEIINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C1</accession>
    <name>K9Z3C1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="4" type="synonym">rpl21</name>
        <name evidence="6" type="ordered locus">Cyan10605_1095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218948.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1095"/>
    <dbReference type="EnsemblBacteria" id="AFZ53217">
        <property type="protein sequence ID" value="AFZ53217"/>
        <property type="gene ID" value="Cyan10605_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1095"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1159"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_1_2_3"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="127" mass="14408" checksum="3544B5FEB8045745" modified="2013-03-06" version="1">MTYAVIEICGKQLKVEPGRFYDIDRINQESETEVSIDKVLLVSHDNDIHVGQPYVESATVSGTIIDHRRGKKVLVYKMKPKKKTRKKRGHRQELTRLMIDSIRIGGNVIAEKTSESKSVETEVAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D6</accession>
    <name>K9Z3D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ordered locus">Cyan10605_1555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219391.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1555"/>
    <dbReference type="EnsemblBacteria" id="AFZ53664">
        <property type="protein sequence ID" value="AFZ53664"/>
        <property type="gene ID" value="Cyan10605_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1555"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1650"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_5_1_3"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="465"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="582" mass="65986" checksum="ED93F019D865D0EE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H2</accession>
    <name>K9Z3H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OpcA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218659.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0795"/>
    <dbReference type="EnsemblBacteria" id="AFZ52928">
        <property type="protein sequence ID" value="AFZ52928"/>
        <property type="gene ID" value="Cyan10605_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0795"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.837"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048410_0_0_3"/>
    <dbReference type="OMA" id="NPCRIIT"/>
    <dbReference type="OrthoDB" id="1406083at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="449" mass="49529" checksum="73FE2ADA92DB47BC" modified="2013-03-06" version="1">MTTPLVSLQAPKDVSLDYIDNELRQIWQMYSGSGDGLAATRASTFSILVYEPDAIQPLLSALGFYTGPIDGIAGPRTTSAIKAAQKAYNFEVTGVSSPELMNKLQEEFKAKSAQGKVNITEATAVKQYSPDMEGAGIADAIASTNPCRIIALVSTTEEDEGVKAQVSAYCPVNKRSENSLICCEYITITGVSSAFERISGIISELMIPDLPKFIWWKAGIDEEYSLFQRLTKECDRIIVDSSIFAQPEIELLKIGQLLEKDIPLSDINWARLSSWQELTAEAFDPPERRSSIWEVDQVTIDYEKGNPNQALMFLGWLASRLNWQPKSCERETGDYDIHKVTLTNPEGKIIKAELAGIPVGDWGEILGDLISLKLTSTNLNADCCTVLCSETTGCMRMEAGGGAQSCRVQQVTSLADQETENLLSKELQRWGKDALYRESMAFTKQILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U8</accession>
    <name>K9Z3U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, BolA protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219603.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1774"/>
    <dbReference type="EnsemblBacteria" id="AFZ53876">
        <property type="protein sequence ID" value="AFZ53876"/>
        <property type="gene ID" value="Cyan10605_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1774"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1883"/>
    <dbReference type="eggNOG" id="COG0271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_2_3"/>
    <dbReference type="OMA" id="HQLVYGA"/>
    <dbReference type="OrthoDB" id="2009812at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9177" checksum="958396593FB7A901" modified="2013-03-06" version="1">MVSLEQVKKTIQQEIPDAEVVIKDLTGGGDHLEAIVVSSQFEGKTKVKQHQLVYSALQAELQSEAIHALALKTYTPSTWSGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y6</accession>
    <name>K9Z3Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Periplasmic polyamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219186.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1343"/>
    <dbReference type="EnsemblBacteria" id="AFZ53457">
        <property type="protein sequence ID" value="AFZ53457"/>
        <property type="gene ID" value="Cyan10605_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1343"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1417"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_11_1_3"/>
    <dbReference type="OMA" id="YANPNPK"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="43785" checksum="55A23482DB8053CD" modified="2013-03-06" version="1" precursor="true">MLSRRLFLLGSGSVALSSVLSGCESASDLSIAILEGSLPNQLITNIKQESAKLGIVRLKPESTLEKLYQSLLTQQEKTINNLNNNSPKSTLQLSIIGNNQREINKQDLTTLGNYWLPFAIENELIDPLDLKILENWSKLSPLFQKLVIRNNQGKLDNQGQIWGAPYRWGYTMIAYREDKLQNLGWQPQDWEDLWKPEIKHRFSLLNQPREVIGLVLKKLGYSYNTKNLKQINNLLPELKTLNQQVKFYDSRNYLQPLILGDTWLAVGWSTDIIPLIERYHNIKAVIPLSGTSLWADIWVKPRNQSSELEKIYNWIDFCWQSKSARQISLFSSGISPVETNFSETNRQIPLMSPEVLAKSEFIEPLESQFFAEYEQIWTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y9</accession>
    <name>K9Z3Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53916">
        <property type="protein sequence ID" value="AFZ53916"/>
        <property type="gene ID" value="Cyan10605_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1814"/>
    <dbReference type="HOGENOM" id="CLU_218275_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="33" mass="4037" checksum="6CB7B5DD20EDB3C2" modified="2013-03-06" version="1">MSEIKDFKDLIIWQKGMEIAEQCYFVLKKFPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B7</accession>
    <name>K9Z4B7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1476"/>
    <dbReference type="EnsemblBacteria" id="AFZ53587">
        <property type="protein sequence ID" value="AFZ53587"/>
        <property type="gene ID" value="Cyan10605_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1476"/>
    <dbReference type="HOGENOM" id="CLU_3151896_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5423" checksum="7048FCE6A1ADFE67" modified="2013-03-06" version="1">MSGRNRGKWPFAPTGRWQVLGCLGDEVMRVEGDKVSGLRFQVLEESNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E7</accession>
    <name>K9Z4E7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transposase IS891/IS1136/IS1341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0051</name>
        <name evidence="9" type="ordered locus">Cyan10605_1117</name>
        <name evidence="10" type="ordered locus">Cyan10605_1501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217944.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0051"/>
    <dbReference type="EnsemblBacteria" id="AFZ52212">
        <property type="protein sequence ID" value="AFZ52212"/>
        <property type="gene ID" value="Cyan10605_0051"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53239">
        <property type="protein sequence ID" value="AFZ53239"/>
        <property type="gene ID" value="Cyan10605_1117"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53612">
        <property type="protein sequence ID" value="AFZ53612"/>
        <property type="gene ID" value="Cyan10605_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0051"/>
    <dbReference type="KEGG" id="can:Cyan10605_1117"/>
    <dbReference type="KEGG" id="can:Cyan10605_1501"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1181"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="RGQARDW"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="171"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="308"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="417" mass="48014" checksum="6857D6859782344F" modified="2013-03-06" version="1">MAIKRVTFRLYPNKAQNEKMHYWRRLHKDLYNACITHRREQYKRYGRSVTYFEQQNSLPEFKEVWIEYKKLGSHALQATVKRVDFAFQRFFKLKSGYPKYKSARHYRGWTYPCKAGWKALSNGKHGRLKISNLGEIKMRGQARDWGEPKTCTILYKQGKWYASITVECIPTRYQTDKGVIGLDFGVNDAIADSSGNFIENPRFLKESQQKINKVAKKARKKRNPRKGIKASCRWKKSAKAVGKIQSKVARQRHNWHHQVSVEIVSRNSFIGTEQLNIKGMTKKAKKGSKRKKQKTGLNRSILDVGIGELKSMIAYKVTEAGGMYIEIPTRKVKPSQTCPKCGHQKKKSLSERVHKCENCGFTTNRDTAAAMVIENYIRGMERASLDAESSSSTECGNMRQIGAKKRQKRISQRSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F9</accession>
    <name>K9Z4F9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_1976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219796.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1976"/>
    <dbReference type="EnsemblBacteria" id="AFZ54071">
        <property type="protein sequence ID" value="AFZ54071"/>
        <property type="gene ID" value="Cyan10605_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1976"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2097"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_1_3"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="136"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="43729" checksum="9851E5CBCDE05080" modified="2013-03-06" version="1">MKIVCSQVDLKNNLSLVSRAVPTRPTHPILANVLLVANQTKNQVTLTGFDLSLGMRSCFCAEVEEEGVITLPAKLLNDIIARLPEGEVTISYEEEEMEENPLVTINSLSGKFQLRGVKGEEYPELPVVEREEAFLLPVAALNEGLKGSLFAASNDETKQILTGVHLTRNLDTLEFAATDGHRLAVVKTSAIEETKESEEEEINSNPPITEAQNFTITIPARALRELEKILSMAKEGESIALFVDEGQVVFELGQQNLTSRKLDGAYPNYNQLIPNNFERTMVVDRKRMIESLERVSVLSDQKNNLVKFTLNSDNEQVTLSVEAKELGNAKESISAEINGDNFEIGFNIRYLMDGLKALSANEIKFQFNGATQPVIATPLSGAQMTYLIMPVQIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J1</accession>
    <name>K9Z4J1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ordered locus">Cyan10605_1543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219379.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1543"/>
    <dbReference type="EnsemblBacteria" id="AFZ53652">
        <property type="protein sequence ID" value="AFZ53652"/>
        <property type="gene ID" value="Cyan10605_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1543"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1638"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_3"/>
    <dbReference type="OMA" id="FFLPDKC"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35238" checksum="CC1A030710A4DA7E" modified="2013-03-06" version="1">MFTATTLPNSNLPQDLFGAIASLKKELNAVILAHYYQEGDIQDIADYIGDSLGLSQQAASTSADVILFAGVHFMAETAKILNPDKLVLLPDLEAGCSLADSCPPDKFAQFKAQHPDHIVISYINCTAEIKALSDIICTSSNAVKIVQQIPPEQPIIFAPDRNLGRYVMEQTGREMVLWDGSCIVHETFSEKKIVQLKIEHPQAQILAHPECETPVLRHADYIGSTTALLKYAMQSNSSEFIIATEPGIIHQMQKDAPHKSFIPAPPENNCNCNECPYMRLNTLEKVYLALKNRTPNIEIPPSIQQKALQPIQRMLEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y3</accession>
    <name>K9Z4Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219202.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1359"/>
    <dbReference type="EnsemblBacteria" id="AFZ53473">
        <property type="protein sequence ID" value="AFZ53473"/>
        <property type="gene ID" value="Cyan10605_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1359"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1434"/>
    <dbReference type="eggNOG" id="ENOG50314XV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119942_0_0_3"/>
    <dbReference type="OMA" id="LWKFQYG"/>
    <dbReference type="OrthoDB" id="1884522at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17834" checksum="13103A5137D121A9" modified="2013-03-06" version="1">MTTPELEINQEFSDLEDFTPSKISHKDEIETVIYSLEENDSAMVQKTDEGYIWKFQYGTVEVFVQLTGETEEDLFKVWSVVLPLPAKNEAELMRLLLEMNWDGTFETNFGIFNNQIVLSTQRTVDDLSASEISRAITLVASLADEYDEELQSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z2</accession>
    <name>K9Z4Z2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219212.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1370"/>
    <dbReference type="EnsemblBacteria" id="AFZ53483">
        <property type="protein sequence ID" value="AFZ53483"/>
        <property type="gene ID" value="Cyan10605_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1370"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_6_3"/>
    <dbReference type="OMA" id="SAITYWK"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="28185" checksum="FDEA4209B1F4FAD1" modified="2013-03-06" version="1">MVKILVIEDEKEIRENILQILRLNNYEATGVENGKLGWEVARENPPDLVICDIMMPEMDGYEFIEKLRIDEKTLMTPCIFVTAKVDKKDIRMGMRMGADDYLTKPFTPDELLEAVDVRLQRKKELEQEFEAKLEKNRKLVQDILEKIKEKDKKIKNNENMLELKDEIISKLIVNMSNPINNMNMAIKMLAEADSEEKRQSYIRVLQEECSKEIGLLNEIKELQKILTPENVSVLLQFNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z508</accession>
    <name>K9Z508_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein, YkoY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219387.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1551"/>
    <dbReference type="EnsemblBacteria" id="AFZ53660">
        <property type="protein sequence ID" value="AFZ53660"/>
        <property type="gene ID" value="Cyan10605_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1551"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1646"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070543_1_0_3"/>
    <dbReference type="OMA" id="IMFLDIV"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022493">
        <property type="entry name" value="CHP03716_TM_YkoY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03716">
        <property type="entry name" value="R_switched_YkoY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="26273" checksum="09AF4D3BEE25CA8E" modified="2013-03-06" version="1">MLEQILHPSIDFGIDTAFILVILVALEAVLSADNAIALASIAQGLKDSKQQRYALNVGLLMAYVLRITLIITAAWIVKFWQFELLGGLYLLWLTFRYFVNSNQENGEDDENSKLNFKNLWQAIPIIAFTDLAFSLDSVTTAIAVADEIWLIIAGGTIGVIALRFLAGLFIHWIQIFTHLEDAGFITVGLVGLRLILKVAYPSLVPPEWLMIGIIIGMFTWGFSEKNDLEVKDSPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z521</accession>
    <name>K9Z521_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219996.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2185"/>
    <dbReference type="EnsemblBacteria" id="AFZ54271">
        <property type="protein sequence ID" value="AFZ54271"/>
        <property type="gene ID" value="Cyan10605_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2185"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015395_1_0_3"/>
    <dbReference type="OMA" id="PIPTDGY"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="31242" checksum="761E0F55347F4325" modified="2013-03-06" version="1">MSNQYSGWSLTARNPEVIEQLMPLWGFLYKYYFQVKTSGWENIPEGPVLFVGSHNGGLAAPDMTMMMYDWFRRFGTQRPIYGLMHRNVWSAYGSLTRLAAQTGAIRAHPKMAIAALEKKASVLVYPGGADDVFRPYTERQKIKFVGRKGFIKLALKYQVPIVPLIAKGAHETIFVVANIYKEIKKLNQQGLFPWMFDIDPQVFPIYFGLPWGLAVGPLPNIPLPLQITTRVCPPIYFPRYGEEASCARLYVQECYDLVVNTMQKELDLLYLGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z585</accession>
    <name>K9Z585_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ordered locus">Cyan10605_1462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219302.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1462"/>
    <dbReference type="EnsemblBacteria" id="AFZ53573">
        <property type="protein sequence ID" value="AFZ53573"/>
        <property type="gene ID" value="Cyan10605_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1462"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1550"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_1_0_3"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="25255" checksum="3488EF074B5E7B34" modified="2013-03-06" version="1">MYLLIPAAGMGKRMGSSRNKLLLELKGKPLLAWTLISADKAESIEWIGIMGQTYDFPTFEEIINQIKPCKPIKLIKGGDTRQESVYNGLQALPEKAEKVLIHDGARCLATPDLFNRCAEVLQECQGLIAAIPVKDTIKIVDSNLLITDTPTRDNLWAAQTPQGFDVKLLKECHDRGLKLGWQVTDDAALLEKCGFPVRIVSGEETNLKVTTPIDLTIAEFILNQRAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z593</accession>
    <name>K9Z593_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219639.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1810"/>
    <dbReference type="EnsemblBacteria" id="AFZ53912">
        <property type="protein sequence ID" value="AFZ53912"/>
        <property type="gene ID" value="Cyan10605_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1810"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1921"/>
    <dbReference type="eggNOG" id="ENOG5032S8N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343536_0_0_3"/>
    <dbReference type="OMA" id="VRNSYFW"/>
    <dbReference type="OrthoDB" id="1765040at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="11505" checksum="217EF95F114F1347" modified="2013-03-06" version="1">MKAYIRDNILYINKEDIPEYQKGKSVVRNNYFWALKSISDYAPFNGDWEFCSEIWIALGRMLLFFYNSGYLGDRETMLEFEDDVLIPDELRAVSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z596</accession>
    <name>K9Z596_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219312.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1472"/>
    <dbReference type="EnsemblBacteria" id="AFZ53583">
        <property type="protein sequence ID" value="AFZ53583"/>
        <property type="gene ID" value="Cyan10605_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1472"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1561"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_3"/>
    <dbReference type="OMA" id="CRWQFLL"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="494" mass="57469" checksum="E916C3B063B3FB02" modified="2013-03-06" version="1">MNNSLQFLKYNLKKYWGYDNFRYPQKEIINSILSGKDCLVVMPTGGGKSLCFQLPALLQKGLTIVISPLVALMENQVLELRQKNLPASILHSEMKKRDRTFTLNLLENQKLRLLYLSPETLLSPPIWKIISHPNLIINALILDEAHCLSQWGDSFRPTYLRLGAIRSSLIKSKLNSSQMAMKKESMILPIAAFTATADNNTQKIIQEYLQLSNPKKFLISPYRDNLRIKIKTIWTPRSRKKQLINHIKNKNKQSGLIYVRTRKDSENISHLLNELGYQNKAYHGGLEASIRRNIEQDWLEEKIKFVVCTSAFGMGINKPNLRWIFHYQTPLFLSEYIQEIGRGGRDGKLAEAITLISEKTGFFNPEDKNIKKYFLQRRIKQYQEALKIIKKLPLQGNIENLSRDKQVYLSILNLSKQLYWLDPFNYQINLKNPQENIKFLIQKQKKLVRLTEEYMGTKKCRWGFLLDAFGFPQGRDFSCGKCDNCEVSIHNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B7</accession>
    <name>K9Z5B7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220100.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2292"/>
    <dbReference type="EnsemblBacteria" id="AFZ54376">
        <property type="protein sequence ID" value="AFZ54376"/>
        <property type="gene ID" value="Cyan10605_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2292"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070318_1_0_3"/>
    <dbReference type="OMA" id="NWQTRLY"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="30454" checksum="96237FD611210FCA" modified="2013-03-06" version="1">MNKYWKLSQSQLNLLQTCPPQFQKVYIEKYTSIPNLSNEEKTVWGKKFHYLMQQYQLGVNIELLKDENPDLIRSAKTLIEATEDIWSNPKIKLREAEYQINYQLDKYLFTVIYDLLVFYDNKAIIFDWKTYPLPENNNRILHNWQTKLYLYILAENSNYLPEQISFTYWFVKQSDKLQNLTINYDQKKHSSTEKELKNLLVNLEKYYQNYRNNNIDFPHHSKCETCFYRKNFAHLFVSNNEFIPQSLDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J3</accession>
    <name>K9Z5J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase PA-phosphatase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219390.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1554"/>
    <dbReference type="EnsemblBacteria" id="AFZ53663">
        <property type="protein sequence ID" value="AFZ53663"/>
        <property type="gene ID" value="Cyan10605_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1554"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_3_0_3"/>
    <dbReference type="OMA" id="RYYAAMI"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="98"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="24839" checksum="17965819E5FA6DED" modified="2013-03-06" version="1" precursor="true">MIKKYIIKPKKVLKNISKNQIIICSITILYFVILTTFVVTGKLKELDEYLLQTIHENLPGWFIYIARASYFLGEAEVAIFFVLFTLGVLVWKKYWEEAQVMAFSCLFILILIDKIFKPLFAISRPLDRLVENAFGNSYPSGHAAGNLLLYFLICYFISQSYPKLKVFLYSLAVFSLILMGISSAYLRVHWVSDIIASYAVGYIMFVFSITILKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K4</accession>
    <name>K9Z5K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219572.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1742"/>
    <dbReference type="EnsemblBacteria" id="AFZ53845">
        <property type="protein sequence ID" value="AFZ53845"/>
        <property type="gene ID" value="Cyan10605_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1742"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1849"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601155_0_0_3"/>
    <dbReference type="OMA" id="NIIACIM"/>
    <dbReference type="OrthoDB" id="1646070at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="19297" checksum="4608F3A5AEEE1E68" modified="2013-03-06" version="1">MLENNHNYLYKLAWEYHPNALIAVNSDLEIQLVNPAFCTLFKLESCAIKGQSAVNILGDIEHLKSAWKENKNIENSIKEYPKPEIFVKEFIYPIEEKNLILCIMIDLTSEIKQKKELTKMQEQMIKQVNNVVNNQMKVAQEIAGLLGETTAETKVNLFKLLQLFNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K9</accession>
    <name>K9Z5K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219752.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1931"/>
    <dbReference type="EnsemblBacteria" id="AFZ54027">
        <property type="protein sequence ID" value="AFZ54027"/>
        <property type="gene ID" value="Cyan10605_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1931"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2052"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070325_1_0_3"/>
    <dbReference type="OMA" id="NGFREAR"/>
    <dbReference type="OrthoDB" id="1983084at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="28055" checksum="59A9CE8165DBA677" modified="2013-03-06" version="1">MNISRIFAIATNGFREVIRDRILYVIGLFVLILVLASRILPPIAVSADEKIFLDLGIGGISLLGAIVAIFVGTGLINKEIEKKTVLILVPKPITNTEFIVGKHLGLSTVLLVLVAVMTITYFALMAMLGIAFPLVSLLVAIAFILLELALLTAVAMTFGVFTSSILATLLSFGVYIMGHLSRDLLELGRITENPSIEKITKALFLILPDLERLNLKNEAVYNILPSTGELLSSVVYAILYIVLLLTISILIFSRRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N2</accession>
    <name>K9Z5N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220183.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2376"/>
    <dbReference type="EnsemblBacteria" id="AFZ54459">
        <property type="protein sequence ID" value="AFZ54459"/>
        <property type="gene ID" value="Cyan10605_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2376"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2523"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_3_3"/>
    <dbReference type="OMA" id="HSCLHYG"/>
    <dbReference type="OrthoDB" id="1661500at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="33397" checksum="416F2FDE39BF1A9A" modified="2013-03-06" version="1">MDKFNQIRGFVLVVESGSFAQASRILGISRSAVNKLVFNLETYLGVQLLHRNTRNVTPTQTGLAFYERCTGILADLEEAEIAVTNLQQRPQGKLRINAPMTFGTINLGDTIASFMAEYPLLKVELSLDDRFVDPIAEGYDMVIRITDKIESSSLVVHQLAEIELILCASEGYIQNYGEPNSPEELENHFCLQYGYFNSPHLWRLTKGDEKKIVKIKSRLCSNNGEILAKGAIADLGITILPRFIIESYLQEGKLRRILPDYSPKTLSLFALYPINRHLSNKIRLLTDFLKNSLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U6</accession>
    <name>K9Z5U6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ordered locus">Cyan10605_2438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220242.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2438"/>
    <dbReference type="EnsemblBacteria" id="AFZ54519">
        <property type="protein sequence ID" value="AFZ54519"/>
        <property type="gene ID" value="Cyan10605_2438"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2438"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2582"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_3"/>
    <dbReference type="OMA" id="GIFDTMQ"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="21634" checksum="9189B8407237E878" modified="2013-03-06" version="1">MIPTVIETSGRGDRAFDIYSRLLRERIIFLGQQVTDELANSLVAQLLLLEAEDPEKDIYLYINSPGGSVSAGLGIFDTMNQIKPDVCTICVGLAASMGAFLLSAGAKGKRMSLPNSRIMIHQPLGGAQGQATDIEIQAKEILYLKKQLNHYMASHTGQPLDKIEEDTERDFFMSAEEARDYGLIDRVVIRSQIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z645</accession>
    <name>K9Z645_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219600.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1771"/>
    <dbReference type="EnsemblBacteria" id="AFZ53873">
        <property type="protein sequence ID" value="AFZ53873"/>
        <property type="gene ID" value="Cyan10605_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1771"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157214_0_0_3"/>
    <dbReference type="OMA" id="MVAKGEM"/>
    <dbReference type="OrthoDB" id="1838024at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12358" checksum="B26E0AB33B834D65" modified="2013-03-06" version="1">MSEPENLLQKAFYLGVGIAGLAVEKANDALQELKEQADKLVINGEFPHRLQQIADEMVNKGKMNTEEARKFVDEILQQQNNQKTSKEENSNSSEPRIIEIITEEEEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B0</accession>
    <name>K9Z6B0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ordered locus">Cyan10605_2637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220434.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2637"/>
    <dbReference type="EnsemblBacteria" id="AFZ54711">
        <property type="protein sequence ID" value="AFZ54711"/>
        <property type="gene ID" value="Cyan10605_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2637"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2801"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_3"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015240">
        <property type="entry name" value="tRNA_sdUridine_synth_fam1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09157">
        <property type="entry name" value="TruB-C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TruB-C_2" evidence="6">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="33443" checksum="EEE71E7AC12B78A1" modified="2013-03-06" version="1">MNGFLNLNKPQNFTSHDCVAKLRKILKTKKIGHGGTLDPLATGVLPIAVGKATRLLQFLPSEKAYKARIKFGIQTTTDDLEGEIIRQQEVKDLTLAKIMDILPEFIGEIDQIPPAYSAIKKDGKKLYDLARKGAVIDIPIRKVFINKIEILNWQESDYPELDLKIVCGGGTYIRAIARDLGEKIGTGATLANLQRTLSCGMTLENSLTFEDVINQKTEEKLSLINLDFPLQNMPKIYLNEEESKNWLLGQKISKITEANYQFYCTYNHKNQFIGISEQRETIETNIKPKIVIYPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D2</accession>
    <name>K9Z6D2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2662"/>
    <dbReference type="EnsemblBacteria" id="AFZ54736">
        <property type="protein sequence ID" value="AFZ54736"/>
        <property type="gene ID" value="Cyan10605_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2662"/>
    <dbReference type="HOGENOM" id="CLU_3268864_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="41" mass="5067" checksum="DD4E78223663A070" modified="2013-03-06" version="1">MKQLEDDFYYPSDDLEYLYHPIVDDEGNLISYQDFIEKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D6</accession>
    <name>K9Z6D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">Cyan10605_2221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220032.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2221"/>
    <dbReference type="EnsemblBacteria" id="AFZ54307">
        <property type="protein sequence ID" value="AFZ54307"/>
        <property type="gene ID" value="Cyan10605_2221"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2221"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2360"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_3"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="24790" checksum="2D257F4A6D763B88" modified="2013-03-06" version="1">MKFGVIVFPGSNCDRDVAMVTEGILNQPTRMVWHQETDIDDLDVVIIPGGFSYGDYLRCGAVARFSPVMKSVIQHAEAGKYVLGICNGFQVLTESGLLPGALIRNRDLHFICDQVPVRVEHNNSVWTKNYQSSQVVCFPIAHGEGNYYADDDTLKELEDNGQILFRYASEKGEINSESNPNGSCKNIAGITNKKGNVLGMMPHPERASDSALGFVDGKDLFTSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L9</accession>
    <name>K9Z6L9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219773.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1952"/>
    <dbReference type="EnsemblBacteria" id="AFZ54048">
        <property type="protein sequence ID" value="AFZ54048"/>
        <property type="gene ID" value="Cyan10605_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1952"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2074"/>
    <dbReference type="eggNOG" id="ENOG5032RJR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2218729_0_0_3"/>
    <dbReference type="OMA" id="LVMRSVN"/>
    <dbReference type="OrthoDB" id="1983561at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021355">
        <property type="entry name" value="Phage_Syn9_Gp224"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11189">
        <property type="entry name" value="DUF2973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11779" checksum="E307891885BF5595" modified="2013-03-06" version="1">MLHLIYILAFTVIAFFAISNLIRSLITISADTQRGTWTDTPRPSKSRQNSPYQASHPELYDEQGKPINEPLLVIRSVSVEDARQKLDSLYESSPSQTRPTEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M2</accession>
    <name>K9Z6M2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220563.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2773"/>
    <dbReference type="EnsemblBacteria" id="AFZ54841">
        <property type="protein sequence ID" value="AFZ54841"/>
        <property type="gene ID" value="Cyan10605_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2773"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_3"/>
    <dbReference type="OMA" id="VRATMPN"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="472" mass="51611" checksum="08E4DC151C436AB0" modified="2013-03-06" version="1" precursor="true">MNKKTFFRHKMLTSISLITLLTYGCGSENSSAPQPKAIPVSTTVLNSSTLIDSTEFVGSLEAVERVNLAPKINGRIMNIFVEEGAIVNRGQLIAELEPEQQQEDVNAATANIQAQVAAYNQSLADLRQTEAQRDSSSSDVARLKASVSSAQANLKTAEANLESAIADLDLAQVNYERSVFLVEQGVLPKQDLDDKTRDLNSSKANVEAQRKTVDAFRSNVASAQEALKSAQSNFAAAQERVESAKANVARSQANIEEAQSNRGSIEQNLAFTRLIAPIDGRVGDFQEFKLGDFLNVGQTLTTITNNRRFHLNLNIPTENIDNLRLGLPVEIIKTDGGVGVRGAVTYIAPLVNQDNQSINIKITFENDGTLKDQQYVRTRLIWDTKPGILVPTNVVTSLGGQKFVFVAREGKSNDDKTTMMAHQVPIQVQGIQGQDYQVTSGIQQGDRIITNRILDLRDKTPISLQEVTSQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N8</accession>
    <name>K9Z6N8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase HEAT domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1973"/>
    <dbReference type="EnsemblBacteria" id="AFZ54068">
        <property type="protein sequence ID" value="AFZ54068"/>
        <property type="gene ID" value="Cyan10605_1973"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1973"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2094"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010860_0_0_3"/>
    <dbReference type="OMA" id="AWWLGKF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="30107" checksum="C87B748E0ED9EF0A" modified="2013-03-06" version="1">MTEANLTPEKAIANLLQKEDLGMRYYAAWWLGKFRVATDEAVNALIQALEDKEDRAPDGGFPLRRNAAKALGKLGFNRSVEPLIKCLDCDDYYVRESAAQALEMLNDTRAIAPLMKLLETAVDGEELTKYGKGTPLGKPHPHEPYEAIIEALGTLKAKNALNLIKPFLKHPIPKVAYGAARAMYQLTEEDSYGEILVTALQGKELQLRRSALMDLGAIGYTSSADAISATFAENSLKLIAMKGLLESAIAKETEEKDSIHPEAVKIMELMDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U8</accession>
    <name>K9Z6U8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ordered locus">Cyan10605_2797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2797"/>
    <dbReference type="EnsemblBacteria" id="AFZ54864">
        <property type="protein sequence ID" value="AFZ54864"/>
        <property type="gene ID" value="Cyan10605_2797"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2797"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2973"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_3"/>
    <dbReference type="OMA" id="LMACNEF"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="35005" checksum="4C3AD8C2C6AF3DC6" modified="2013-03-06" version="1">MKIVVTGASGFLGRHLLPQLKQKYPHAKIIGLSSKDYDLMNPVAVVKMFEDLHPEILIHLAAYSGGIGANRAYPADFYYRNTLLTALVFEQAARFNVKKMIYTMGGCSYPATAKSPIDESQMWEGYPQPESAGYSSAKKMGIVASQSYRTQYGLNSVVLIPGNLYGEYDNFRNNESHVVPALLRRFYEAKLNGLDEVTMWGTGTPKRDFVYAEDVAKVIPYFIENYDSSEPVNISSGTTTPIKELAETIKEVTGFAGKLSWDTTKPDGQMVKIFDVSRLNSFDLSCDTSLKDGLEKTFAWLSQNYANKTDGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W9</accession>
    <name>K9Z6W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220030.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2219"/>
    <dbReference type="EnsemblBacteria" id="AFZ54305">
        <property type="protein sequence ID" value="AFZ54305"/>
        <property type="gene ID" value="Cyan10605_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2219"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2358"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038899_0_0_3"/>
    <dbReference type="OMA" id="NLMWGDG"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="432" mass="48545" checksum="A6EF9ABA2CA7B1DF" modified="2013-03-06" version="1">MLKIISFPLGIIFGLIILGGCHNSPPKLPPLAQEESIQVYFNHNQAKGKEYEEPYRKIKRFGDDLETVLIEQINSANQTIDIAIQELNLARLARAIVEKKKQGVKIRIVTENNYNKPLNQLPNNHGLAILKRANIPIIDDTEDGSKGSGLMHHKFVIIDQKKVVTGSANFTLSGIHGDFDNQETRGNTNHLIVFNSQEMAKIFTQEFNYLWGDGVGKKKDSLFGLNKPERRTKIVNIGSSSIVVKFSPNSRSTLWENSSNGIIARELAKANSSIDLALFVFSDQEIANTLEKESLSGVKIRVLIDPNFAYQYYSEGLDLLGVAIPRKCVYENDNNPWQQPLKTVGIPALPLGDKLHHKFAIIDRYIVITGSHNWSNSANHINDETLLVIYNPLIAQHFQREFDYLYHDAILGVSSELKKEIDQENSKCGLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X6</accession>
    <name>K9Z6X6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2229"/>
    <dbReference type="EnsemblBacteria" id="AFZ54315">
        <property type="protein sequence ID" value="AFZ54315"/>
        <property type="gene ID" value="Cyan10605_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2229"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2370"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107036_0_0_3"/>
    <dbReference type="OMA" id="ICETINQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="190" mass="22138" checksum="AE7DEB85FC8070D8" modified="2013-03-06" version="1">MTIASTQIKGLTLEEFLQQDYIDESPAYEYIDNQIIRKPMPQGKHSQIQYKICETINQLSEKEKIVYALPELRCSFSNRSIVPDIAVFYWARIPLDNQGEIANQFNSYPDWTIEILSPNQTPTRVIDNILFCLENGSQLGWLIDSQEKIIMVFQAEKPLKIYRQDETLPIIENINLPITPNNIFSWLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y8</accession>
    <name>K9Z6Y8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220230.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2425"/>
    <dbReference type="EnsemblBacteria" id="AFZ54507">
        <property type="protein sequence ID" value="AFZ54507"/>
        <property type="gene ID" value="Cyan10605_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2425"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2569"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_3_0_3"/>
    <dbReference type="OMA" id="MTAYTIN"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22183" checksum="58A22EEDB16DB9F2" modified="2013-03-06" version="1">MTAYTINFDVISTIDDEKFYQLCRHNPELKLEKNQKGELVIMSPTGGETGKKNSELNADFVIWNRQKKLGYIFDSSTCFKLPKGSNRSPDVAYIQKERWDNLKEEERIKFPPLAPDFVLELISKTDSLKDTQEKMQEYIDNGVKLGWLINPEKKEVEIYRQEGEKEVLNNPKILSGEDILPDFTLDLTEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z748</accession>
    <name>K9Z748_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220290.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2486"/>
    <dbReference type="EnsemblBacteria" id="AFZ54567">
        <property type="protein sequence ID" value="AFZ54567"/>
        <property type="gene ID" value="Cyan10605_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2486"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2635"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_3"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="258" mass="27913" checksum="E1730C7A6AEE8687" modified="2013-03-06" version="1">MVDRTSLEILLKQIAEGKITPSEGVEKLKYLNFEAIDNFAKIDHHRQLRTGFPEVIWSQGKTPEQIRQIIHVMRQNSPLVMATRLEADVAETLQEQIQDLRYYPLAKIAAIGQNSNKYKGKISIVTAGTADLPVAEEAAITGELCGFTVERLWDVGVAGIHRLLNHRHLITQADILIVVAGMEGALPSVVAGLANCPVIAVPTSIGYGTSFGGLSALLTMLNSCATGIGVVNIDNGFGAAMLAGQILRLANRFSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z772</accession>
    <name>K9Z772_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220144.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2336"/>
    <dbReference type="EnsemblBacteria" id="AFZ54420">
        <property type="protein sequence ID" value="AFZ54420"/>
        <property type="gene ID" value="Cyan10605_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2336"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2480"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_2_3"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="33497" checksum="843D9A858C23B8A1" modified="2013-03-06" version="1">MVQDNRKKVRQVLIITLILNLVVLLLKAVVGTITGSLSLQADALHSVTDSANNILGLVTNQLSSPIPDRDHPYGHQKFEAIGALGIAAFLGIACFEIITGALNRIIFGGDPVKIGGSELWLLIIVLGINIFVAFYERKVGYKIGSKILIADATHTMSDVWITISVLFGLIGVWQSERLNLPQLQYLDILLAFPVAFLVLKSGWQVLTSNLPWLVDQVVIAPELIHKIVTEVPGVINCHDIASRGLLGRQIFIEMHLIVDTEDVKIAHDITEEIERKLEEKFAPVRILIHIEPPEYKSPKISYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A0</accession>
    <name>K9Z7A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220174.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2367"/>
    <dbReference type="EnsemblBacteria" id="AFZ54450">
        <property type="protein sequence ID" value="AFZ54450"/>
        <property type="gene ID" value="Cyan10605_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2367"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2513"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_2_1_3"/>
    <dbReference type="OMA" id="HPYNVSL"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="38258" checksum="6CBA2FCDB1AE764C" modified="2013-03-06" version="1" precursor="true">MSKITRRVFLGTSAAIGAVALGELTGIKSSSAQAKQINLYSSRHYNTDQRLYTDFEKQTGIKVNLVEGKAEQLLERIRSEGRNSKADVFLTADAGNLWQAQQAGIFSPVSSSVLTQKIPSYFRDPNNNWFGFSKRIRVIMYNKSKVNPSQLSTYEDLANSKWRKKIAIRSSSNIYNQSLVAWLIAINGQQKTEEWCRGIVANMARPPQGGDRDQIEAVAAGIADLAVANTYYLAGYGASNDPQKKAIFNKVGVFFPNQKGRGAHANISGGGVLKNAPNRAGAVKFLEYLVSPSAQRFFAQGNNEYPVVEGIALDPVLASFGSFKSDVTSVAKYGPNLANAVKIMDRAGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E1</accession>
    <name>K9Z7E1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2413"/>
    <dbReference type="EnsemblBacteria" id="AFZ54495">
        <property type="protein sequence ID" value="AFZ54495"/>
        <property type="gene ID" value="Cyan10605_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2413"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143452_1_1_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13516" checksum="997A563449E7E2F0" modified="2013-03-06" version="1">MENIILVDTSPLIAILSPQDNYHKLCVDTLKTIKPPLLTTWAVITETLWLIRHNRKAIQSLFKMIEGGLVQIDPLSDNTISWLNQFMLKYHDMGVQVADASLCYLGEIYNLKVVFTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E5</accession>
    <name>K9Z7E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hopanoid biosynthesis associated protein HpnK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220835.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3059"/>
    <dbReference type="EnsemblBacteria" id="AFZ55116">
        <property type="protein sequence ID" value="AFZ55116"/>
        <property type="gene ID" value="Cyan10605_3059"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3059"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3260"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_2_0_3"/>
    <dbReference type="OMA" id="DFELGCH"/>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017836">
        <property type="entry name" value="Hopanoid_biosynth-assoc_HpnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03473">
        <property type="entry name" value="HpnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="31863" checksum="60A8DEC0C6F64D9C" modified="2013-03-06" version="1">MKVADKYVVVNADDFGYSDEINEAIIEAHRNGILSSTSLMVTAEKAKSAVKLAKENPSLGVGLHLVLCCGKSALNPQQIPNLVNKEGLFHDSAAIAGLKYQFIPSARQELKREIKAQLDLFRETGLKLSHVDGHLHLHIHPIVIQILAQLAPEYQIKFIRLPYEELNFTLKLDRTNPILKIIYANIFRWLRKSAKKPLSTSGVQFLDRVYGLLQTGNMSESYLLGLIPQIKTIYNEIYFHPQSLTDQEYQALCSQKVQEIILTEGFKVVNYFQLGKARGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F6</accession>
    <name>K9Z7F6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220845.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3069"/>
    <dbReference type="EnsemblBacteria" id="AFZ55126">
        <property type="protein sequence ID" value="AFZ55126"/>
        <property type="gene ID" value="Cyan10605_3069"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3069"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3272"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_0_3"/>
    <dbReference type="OMA" id="GDDVMLY"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="24698" checksum="CD7E5673531CF804" modified="2013-03-06" version="1">MFSSIIADFKIIFERDPAARNWLEVLLCYPGLQALLLHRFSHWLYNLGLPLIPRLLSHFGRFFTGVEIHPGATIGKGVFIDHGMGVVIGETAILGDYCLIYQGVTLGGTGKEKGKRHPTLGENVVVGAGAKVLGNILIGNEVRIGAGSVVLKDVPSDCTVVGIPGRIVYRAGAKVDPLDHSNLPDSEAKVIRTLLDHEAALRDRIEKLEKQVTELQQQSLEARYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G0</accession>
    <name>K9Z7G0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ordered locus">Cyan10605_3074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220850.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3074"/>
    <dbReference type="EnsemblBacteria" id="AFZ55131">
        <property type="protein sequence ID" value="AFZ55131"/>
        <property type="gene ID" value="Cyan10605_3074"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3074"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3277"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_5_2_3"/>
    <dbReference type="OMA" id="ICDTINY"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="25126" checksum="D472913D0B9D9803" modified="2013-03-06" version="1">MNSPIQAVSAPYRGDAYYRTPPPDLPSLLLKERIVYLGLPLVSPDEYKDQLGVDVTELIIAQLLYLQFDDPEKPIYLYINSTGTSWYGGDSIGFETEAFAICDTINYIKPPVHTICLGQAMGTAAMILASGTKGCRASLPHATIILHQARQGAQGQATDIQIRAREVIVNKRVMLDILSAKTGQPKEKIEKDTDRMFYMNPQQAKEYGIIDKILESTKQLPTPVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M1</accession>
    <name>K9Z7M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220868.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3093"/>
    <dbReference type="EnsemblBacteria" id="AFZ55149">
        <property type="protein sequence ID" value="AFZ55149"/>
        <property type="gene ID" value="Cyan10605_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3093"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_8_2_3"/>
    <dbReference type="OMA" id="TMGIMPG"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8291" checksum="34DD34B54929BDCE" modified="2013-03-06" version="1">MSNYFPLSDLKVGSQAIVAKLETQDEGIIRHLMAMGVIQGVNISLESKFPSYVLSVGKSRTALDKETASIIYVSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y3</accession>
    <name>K9Z7Y3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220569.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2780"/>
    <dbReference type="EnsemblBacteria" id="AFZ54847">
        <property type="protein sequence ID" value="AFZ54847"/>
        <property type="gene ID" value="Cyan10605_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2780"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2953"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_3_0_3"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="387" mass="43554" checksum="D804D64F804B8BE1" modified="2013-03-06" version="1">MRLFISTGEVSGDLQGGLLVKALFQQAEKLNIPLEIEGLGGKKMAEAGAKLIADTTAIGSVGLWESVPFIIPTLQIQNKAKKYLQTHLPDAIILIDYVGPNLAIASSLKKKYPNTPIIWYIGPQFWVWTPLGQDVEQLVKVTDKLLAIFPEEAKFYQEKGMNVTYVGHPLTDRIKKAPSRETARKKLGIQETERMIVLLPASRQQELKYLLPVMVESAKKIQAKFPTIKFYLPISLAKYKQEIERVINQNQLKITLFEGETLEILAGADLAITKSGTVNLELGLLKIPQIVIYKVNKLTMWVARKILNFSIPFMSPVNLVSMTEIVPELLQEKATVENITHLAEELLFNSSRQHQLSQDYATMIKVLDNQEDSVCDRVAQEIINYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y7</accession>
    <name>K9Z7Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221024.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3260"/>
    <dbReference type="EnsemblBacteria" id="AFZ55306">
        <property type="protein sequence ID" value="AFZ55306"/>
        <property type="gene ID" value="Cyan10605_3260"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3260"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3475"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="VRQADRY"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43820:SF5">
        <property type="entry name" value="PTHR43820:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="25893" checksum="2E45B92FB5C3A14F" modified="2013-03-06" version="1">MLNLSNLNVYYGESHILRNVDLTINSGEMVCLIGRNGVGKTTLLKTIMGLLQSRTGNLIFKEQPLQKLTTDKRAKLGIGYVPQGREIIPRLTVKENLLLGLEALPNNTKVRKVIPAEIFDLFPVLKTMLNRMGGDLSGGQQQQLAIARALMGRPQLLLLDEPTEGIQPSIILEIETAVKKIIKETGISVLLVEQHLHFVRQADRYYAMQKGGIVASGKTRELSQRVIQEFLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z811</accession>
    <name>K9Z811_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221049.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3285"/>
    <dbReference type="EnsemblBacteria" id="AFZ55331">
        <property type="protein sequence ID" value="AFZ55331"/>
        <property type="gene ID" value="Cyan10605_3285"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3285"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3500"/>
    <dbReference type="eggNOG" id="ENOG502ZBR1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314391_0_0_3"/>
    <dbReference type="OMA" id="EGGKSAY"/>
    <dbReference type="OrthoDB" id="1484829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939149" evidence="1">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="22340" checksum="45D711967CDAD503" modified="2013-03-06" version="1" precursor="true">MKINSILLFLVTVCSTFSFSTIAKADSIQSRCDIYPKGEDKASKVVNCIFSQRQGFITITREDGVTYDLEPSDNQYIDQNGKTVTKEIDGNTLIFRFQKESVYLYQGEKAPSSSNSSHSLAQTPENLISTTPTALKDLVGAKAGQAENTLISRGYTYRNTVTFEGGKSAYYVENKTGYCVEVGTVDGRYSSIVYNTSDRCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z829</accession>
    <name>K9Z829_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220443.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2646"/>
    <dbReference type="EnsemblBacteria" id="AFZ54720">
        <property type="protein sequence ID" value="AFZ54720"/>
        <property type="gene ID" value="Cyan10605_2646"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2646"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417250_0_0_3"/>
    <dbReference type="OMA" id="PIVLCFD"/>
    <dbReference type="OrthoDB" id="392682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="654" mass="76324" checksum="F22DE3E3AF14A65F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z845</accession>
    <name>K9Z845_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3273"/>
    <dbReference type="EnsemblBacteria" id="AFZ55319">
        <property type="protein sequence ID" value="AFZ55319"/>
        <property type="gene ID" value="Cyan10605_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3273"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3488"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023976_0_0_3"/>
    <dbReference type="OMA" id="FPIVPGM"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="581" mass="65506" checksum="0E380A6D4BC37D65" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z878</accession>
    <name>K9Z878_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221119.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3359"/>
    <dbReference type="EnsemblBacteria" id="AFZ55401">
        <property type="protein sequence ID" value="AFZ55401"/>
        <property type="gene ID" value="Cyan10605_3359"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3359"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3577"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_6_0_3"/>
    <dbReference type="OMA" id="TELMGEN"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22980" checksum="16A4649931466CCF" modified="2013-03-06" version="1">MVTAITKGATTSKTSPITVEEYLAQEEISKEKNEFIEGEIIKMAGASANHNRLAVNFSRLLPLEINNQSYEIFVSDMKLLAPDGENYFYPDVMVIKGEPRFTNEKQTAVTNPCLIAEILSNSTEGFDKNQKFAFYRTIPELKEYILIDQEDYRVELYRKVGKNQWLLTELMSQEDVLTLESIEVEISLADLYKRVKFTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C7</accession>
    <name>K9Z8C7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3362"/>
    <dbReference type="EnsemblBacteria" id="AFZ55404">
        <property type="protein sequence ID" value="AFZ55404"/>
        <property type="gene ID" value="Cyan10605_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3362"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3580"/>
    <dbReference type="eggNOG" id="ENOG5032Z0M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180396_0_0_3"/>
    <dbReference type="OMA" id="FKIHQDG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021375">
        <property type="entry name" value="DUF2997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11211">
        <property type="entry name" value="DUF2997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="8139" checksum="4E453BD592141703" modified="2013-03-06" version="1">METLEFIIYPDGRVQEKVTGIIGKSCQEVTEAIEAQLGRIISQEKTGDYYQENLETTNQFNHHQTNNYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q6</accession>
    <name>K9Z8Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Cmr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221261.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3511"/>
    <dbReference type="EnsemblBacteria" id="AFZ55544">
        <property type="protein sequence ID" value="AFZ55544"/>
        <property type="gene ID" value="Cyan10605_3511"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3511"/>
    <dbReference type="eggNOG" id="COG1769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737327_0_0_3"/>
    <dbReference type="OMA" id="VFPPNGH"/>
    <dbReference type="OrthoDB" id="1656967at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="42822" checksum="AC2F5AAC763DE0F9" modified="2013-03-06" version="1">MFWYKLTPIDVLLLRDGKPFSPGERAWAASVFPPNGHTLAGAIRGLLGKKTNFNLIGSFLTYGDQLYFPRPLNYVGKNLLYPLPWLESDYPLQKILWDRLQPAPLLLKQLKEREPKTSKSEEKTGKYISFNQLKNLLTKAVNEHHNKVELELENPVESEPYFSETRSHNAINSQTGQVKESDGYFVENAIRLKQGWSLAIALDFKLPTPNIMQLGGEGHRVIIEECPDLAQQWQELTKLSQGNFEENQANKSKSLAYLTTTGIFERKYQNNKVYCQAWPWEWKLAHRVNGNQTIGNLVSVATAKPVPISCRIQDREKNTSIPAPQVFGATAGSVYYLNQPEYLYAENPQSPPTKGLEVAKKWRSLGYSQLLWFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T9</accession>
    <name>K9Z8T9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_3080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220856.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3080"/>
    <dbReference type="EnsemblBacteria" id="AFZ55137">
        <property type="protein sequence ID" value="AFZ55137"/>
        <property type="gene ID" value="Cyan10605_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3080"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3283"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002404_1_0_3"/>
    <dbReference type="OMA" id="NNHPHTA"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="11">
        <location>
            <begin position="804"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127525" checksum="3DFC3C7162298795" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z0</accession>
    <name>K9Z8Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neutral amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2770"/>
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        <property type="protein sequence ID" value="AFZ54838"/>
        <property type="gene ID" value="Cyan10605_2770"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2942"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="YGVGFEQ"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ANF_receptor" evidence="4">
        <location>
            <begin position="67"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="45296" checksum="FA5A850484F4D382" modified="2013-03-06" version="1" precursor="true">MKKTNIRLFLSLFISLNWVTVGCGLLGTNTEDSGNNANTTSGAESLKVGTLLPITGDLSSIGQNMPTAVQLAVDTINACGGVNGQPVTLVKEDSQTDPVAGSAAMTKLTEVDKVAGVVGAFASSVSTAALDVAVRNNVMMISPGSTSPIFTQRAKTGDFNGYWARTAPPDTYQAQALAALAKKQGFQNVSTVVINNDYGVAFEQEFVNSFQDLGGTVLNSSNPVRYDPKAVTLDSEASATFANNPQAVAGVLYAETGSLLLQAAFKQGLTNGVTVLLTDGVYSEDFTKQVGKTADGNSIIAGALGTVPGADGKALEDFKNLWAERTNNTPITAFVPHTWDATILLMLAAQAAGENSGEAIKGKIREVSGGEGTEVTDPCQAMELLRNGEQINYQGASGNVDIDENGDVVGVYDVWQVQPDGSIEIIDKVSPIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z1</accession>
    <name>K9Z8Z1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220789.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3010"/>
    <dbReference type="EnsemblBacteria" id="AFZ55070">
        <property type="protein sequence ID" value="AFZ55070"/>
        <property type="gene ID" value="Cyan10605_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3010"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3207"/>
    <dbReference type="eggNOG" id="ENOG5032SXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150503_0_0_3"/>
    <dbReference type="OMA" id="MQDKQKV"/>
    <dbReference type="OrthoDB" id="1804571at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="12703" checksum="41908F20FE8E1441" modified="2013-03-06" version="1">MQDKQKVTLYLPPTLHRQLKVKAAIETDSMSALVEKAISFYLQHPETVEEVEASYGKTHQVHVCPECNAAMVMRDGKMISLKNQPSIVDEEFPLIGEKSSVTTGTEGQEELIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z909</accession>
    <name>K9Z909_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220585.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2796"/>
    <dbReference type="EnsemblBacteria" id="AFZ54863">
        <property type="protein sequence ID" value="AFZ54863"/>
        <property type="gene ID" value="Cyan10605_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2796"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2971"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_3"/>
    <dbReference type="OMA" id="QFVYAYI"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939157" description="Phosphate-binding protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="46"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="361" mass="38939" checksum="D16F01E7FB83ECDC" modified="2013-03-06" version="1" precursor="true">MGKFKSLIPSALGGLLFLSAGLTACGDKSTSSVSAPSVDPNQIVMLKGSGATFPAPLYQKWIQEYSSTDDKKNIRISYDSVGSGAGVKNFLAGEGDFGATDAPLKNEERQKFPENRGKPLQIPMTGGLLVFAYNLANYEGLDNIRLSRNTYCGIVTGKITKWNDPAIVADNPDVRLPDIPLLFVHRSDGSGTTFIFTSHIEAVCPDWKAGSGKEVEWPIGIPAPGNEGVSTQIQQTAGAIGYIEYSYSKDKNLQTAVLENKSGNFIKPSPENASKAFVGQTVPDDFALVIPDTESPDAYPIVGLTWLLLYTNYDDPSKAEVVKNFVQWSLVEGDESASTLGYLPIPDDLQEKVITTLNQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z910</accession>
    <name>K9Z910_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220809.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3031"/>
    <dbReference type="EnsemblBacteria" id="AFZ55090">
        <property type="protein sequence ID" value="AFZ55090"/>
        <property type="gene ID" value="Cyan10605_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3031"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_5_1_3"/>
    <dbReference type="OMA" id="YRIGFKY"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="88" mass="10772" checksum="7789C5B2DB865A7F" modified="2013-03-06" version="1">MKVKFESAFAKDLQKIKDKKLSEQIKYVILECKKAELFNQVKNVKKLTGYNNFYRIKIRDYRIGLEIQEDTIIFTRFLHRKDIYKYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z923</accession>
    <name>K9Z923_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phycocyanin, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220925.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3156"/>
    <dbReference type="EnsemblBacteria" id="AFZ55207">
        <property type="protein sequence ID" value="AFZ55207"/>
        <property type="gene ID" value="Cyan10605_3156"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3156"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3363"/>
    <dbReference type="eggNOG" id="ENOG502Z7NE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_0_0_3"/>
    <dbReference type="OMA" id="GITPGDC"/>
    <dbReference type="OrthoDB" id="1307812at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006247">
        <property type="entry name" value="Phycocyanin_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01339">
        <property type="entry name" value="phycocy_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="4 5" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="3 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="172" mass="18303" checksum="84140660269158DF" modified="2013-03-06" version="1">MYDAFTRVVSQADARGEFLSSAQIDALSQMVSDSNKRMDTVNRITSNASAIVTNAARSLFAEQPQLIAPGGNAYTSRRMAACLRDMEIILRYITYAIFSGDASVLEDRCLNGLRETYLALGTPGASVAVGVQKMKDAALAIANDTNNITLGDCSALMAEVASYFDRAAAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z981</accession>
    <name>K9Z981_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220879.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3107"/>
    <dbReference type="EnsemblBacteria" id="AFZ55160">
        <property type="protein sequence ID" value="AFZ55160"/>
        <property type="gene ID" value="Cyan10605_3107"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3107"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3311"/>
    <dbReference type="eggNOG" id="COG3558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112790_1_1_3"/>
    <dbReference type="OMA" id="VRFQYEC"/>
    <dbReference type="OrthoDB" id="1650155at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="17301" checksum="A77F3499523E7D80" modified="2013-03-06" version="1">MESKPPFPPFNLETAQQKVQMAEDAWNTRDPEKVVLAYTIDSQWRNRSEFLSGREEIKAFLYRKWAKELDYRLRKELWAFTDNRIAVRFEYEWHDESNQWYRSYGNEMWEFAENGLMQNRFASINDVLIKESERKFLWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9F4</accession>
    <name>K9Z9F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chlorophyll a/b binding light-harvesting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cellular thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221075.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3312"/>
    <dbReference type="EnsemblBacteria" id="AFZ55357">
        <property type="protein sequence ID" value="AFZ55357"/>
        <property type="gene ID" value="Cyan10605_3312"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3312"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3526"/>
    <dbReference type="eggNOG" id="ENOG502Z92X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028310_0_0_3"/>
    <dbReference type="OMA" id="FGEYTEF"/>
    <dbReference type="OrthoDB" id="417558at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009521">
        <property type="term" value="C:photosystem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33180">
        <property type="entry name" value="PTHR33180"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="SSF161077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="37631" checksum="F1A51DCDAF909412" modified="2013-03-06" version="1">MQTYDNPEVKYEWWAGNARFADKSGLFIAAHVGQAALTTFWAGGFTLFELSRFDASLPMGEQGLILLPHLATLGWGVGEGGQIVDTYPYFVVGAIHLISSAFLGAGALFHTFKAPENLKSAQGRAKMFDFSWEDPAKLGLILGHHLLFLGMGALLLVGKAMYWGGLYDATTQTVRLVEHPTLDFATIYGYQTHFASISSLEDLVGGHIYVGFMLIAGGIWHILVPPLKWARKVLMFSGEAILSYSLGGIALAGFVAAYFCAVNTLAYPVEFYGPALEVKLGITPYFADTVKLPFGEHTSRCWLANAHFFLAFFFLQGHLWHALRALGFDFRRVEKALDSIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G2</accession>
    <name>K9Z9G2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ordered locus">Cyan10605_3159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220928.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3159"/>
    <dbReference type="EnsemblBacteria" id="AFZ55210">
        <property type="protein sequence ID" value="AFZ55210"/>
        <property type="gene ID" value="Cyan10605_3159"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3159"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3366"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_3"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="39009" checksum="BDB9E239F0A95218" modified="2013-03-06" version="1" precursor="true">MNKVLVGLSGGVDSSVAAASLQKQGYHVEGVTLWLMKGKGQCCSEGMVDAAHICEQLGISHHIVDIRDVFQENIIDYLVTGYEGGVTPLPCSQCNRTVKFPPMLEYAQNTLGIDKIATGHYARVVYDERCDRFQLLKAIDDNKDQSYFLYDLPQEILSHLIFPLGNQTKTETRAMAEALNLKTAKKPESQDLCLIEAHGNMKEFLNKYITPKQGQIVDLEGNILGEHEGIHHYTIGQRRGLGIAYSEPLYVLKLDPVMNQVIVGTRDQGGETECYVNRVNWVSIASPKVPLKAEAKVRYRANPQQVNIIPLENNRVKLVFDEPQFGITPGQAAVFYHQEILLGGGIIERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J8</accession>
    <name>K9Z9J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220968.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55250">
        <property type="protein sequence ID" value="AFZ55250"/>
        <property type="gene ID" value="Cyan10605_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3202"/>
    <dbReference type="eggNOG" id="ENOG50344A4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2568120_0_0_3"/>
    <dbReference type="OrthoDB" id="2029092at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9383" checksum="35838E71E56FC117" modified="2013-03-06" version="1">MTKLQIKEKINNYLDKLPTSKLEEIASYIENNYSTEKLTYQSKKQPSSLGKKLRAIRAKIIAEGEPLLTAEQVEIEKKMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA36</accession>
    <name>K9ZA36_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221297.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3549"/>
    <dbReference type="EnsemblBacteria" id="AFZ55582">
        <property type="protein sequence ID" value="AFZ55582"/>
        <property type="gene ID" value="Cyan10605_3549"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3549"/>
    <dbReference type="HOGENOM" id="CLU_2286831_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11898" checksum="29FE91360DAB80F8" modified="2013-03-06" version="1">METQITLRIKEEIKVNITVLMLDVLIPNYYDELTPVLGIYEENEFKSTIGYWLVSEWLYRQLLAHHQPVVKFKNLYIWGRMGTGYSLNDEEVLITIFGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA94</accession>
    <name>K9ZA94_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221233.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3479"/>
    <dbReference type="EnsemblBacteria" id="AFZ55515">
        <property type="protein sequence ID" value="AFZ55515"/>
        <property type="gene ID" value="Cyan10605_3479"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3479"/>
    <dbReference type="eggNOG" id="ENOG502ZWRJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232119_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="11765" checksum="8A1D79A1507C699B" modified="2013-03-06" version="1">MTIGKITNKIAISSRQKSVSPNLELINNARKSNKNKVEKKNNNYSQSQKYLTIFKYLILSTTIIFSFGGLGFGLALRYGHSWKVSHSLQELGVRSSDLGVKTNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAA4</accession>
    <name>K9ZAA4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="7" type="ordered locus">Cyan10605_3252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221016.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3252"/>
    <dbReference type="EnsemblBacteria" id="AFZ55298">
        <property type="protein sequence ID" value="AFZ55298"/>
        <property type="gene ID" value="Cyan10605_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3252"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3467"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_1_3"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938655" description="Peptide methionine sulfoxide reductase MsrA" evidence="5">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PMSR" evidence="6">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22474" checksum="A7DB225618B8FA0F" modified="2013-03-06" version="1" precursor="true">MSKILAIIISIFLILSPSANAQTDKIQTATFAGGCFWCMEPPYDKVEGVISTTSGYTGGNVKNPTYKQVSQGQTGHAEAVQVKYDSSKVNYEDLLDIFWKNIDPTVKNRQFCDVGNQYRSGIFYHSEEQKQLALASREKVEKQLNGKIYTEITPVKDFYPAEEYHQDYYKKNPLLYKYYRFRCGRDQRLKELWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAE1</accession>
    <name>K9ZAE1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221277.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55560">
        <property type="protein sequence ID" value="AFZ55560"/>
        <property type="gene ID" value="Cyan10605_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3527"/>
    <dbReference type="HOGENOM" id="CLU_1193217_0_0_3"/>
    <dbReference type="OrthoDB" id="1890075at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26338" checksum="AC5EDBC6F5B523E9" modified="2013-03-06" version="1">MWLNTIKLSDLLFLVIIGLNFITEPSRSFPAPSLYKQGGIDAKFVKDNFYPESSTDNIWTRKIDLNNDKIPEILVVNSNRKWCGSAGCATSVYSYLNGKWREVLSFTGNGVTERNTTTRGWKDLSASPNERINPVWVFNGEKYNVGYLLDTKHNLKINPQDSSANIVRATNAFDGAGTNYPVRQKLTNNQSIFLHGFVKTRSGQIWYVGYASEADRYNPFYVEKSNIQINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAT9</accession>
    <name>K9ZAT9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent nickel-iron dehydrogenase subunit HoxY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221226.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3472"/>
    <dbReference type="EnsemblBacteria" id="AFZ55508">
        <property type="protein sequence ID" value="AFZ55508"/>
        <property type="gene ID" value="Cyan10605_3472"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3472"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3697"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093095_0_0_3"/>
    <dbReference type="OMA" id="CNAENVH"/>
    <dbReference type="OrthoDB" id="1280734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20138" checksum="AD4FD962DE3E1C73" modified="2013-03-06" version="1">MDKIKFATVWLAGCSGCHMSFLDLDEFLFDIAEAVDMVYSPVASDIKDYPDNVDVCLVEGAIANEENLKLLLEVRRKTKFLISFGDCAVTANVPAMRNMLNGSDPVLKRCYLELSDHGGQIPKDPEIVPPLLEKVQPIHHVVEVDLFLPGCPPSAQRIKNAIAPLLKGEKPIMEGRDMIKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAV6</accession>
    <name>K9ZAV6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221241.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3488"/>
    <dbReference type="EnsemblBacteria" id="AFZ55523">
        <property type="protein sequence ID" value="AFZ55523"/>
        <property type="gene ID" value="Cyan10605_3488"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3488"/>
    <dbReference type="HOGENOM" id="CLU_2022886_0_0_3"/>
    <dbReference type="OrthoDB" id="2162012at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13773" checksum="17475F2473494A1E" modified="2013-03-06" version="1">MKTHECLDIVLTEYKDFFCARDLARISGVPEVTLSLFRNGEKNTGVKIFDKIREGLKKLSPEAYQRFIELLAEAELEPPKPDLVKLIAEAPFSVQAEVLKTIASNGVFTLLSELAQEKRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZS2</accession>
    <name>K9YZS2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218183.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0303"/>
    <dbReference type="EnsemblBacteria" id="AFZ52451">
        <property type="protein sequence ID" value="AFZ52451"/>
        <property type="gene ID" value="Cyan10605_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0303"/>
    <dbReference type="eggNOG" id="ENOG5032RRW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090160_3_0_3"/>
    <dbReference type="OMA" id="FYGFFTE"/>
    <dbReference type="OrthoDB" id="1893908at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007572">
        <property type="entry name" value="Uncharacterised_Ycf20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33787">
        <property type="entry name" value="PTHR33787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04483">
        <property type="entry name" value="DUF565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12309" checksum="E74DE3B7ADC1184F" modified="2013-03-06" version="1">MQETRLNLLIGNFTNQIKSFLNNPWRKLSFVIIGFLSGYITSDLLSTSLAQAGKWDVPMATTYLIFTEITSMIVYGGSKNRNKIMWADLLNSFKIGLAFGLYLSAMTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z088</accession>
    <name>K9Z088_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218347.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0474"/>
    <dbReference type="EnsemblBacteria" id="AFZ52616">
        <property type="protein sequence ID" value="AFZ52616"/>
        <property type="gene ID" value="Cyan10605_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0474"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.502"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168735_0_0_3"/>
    <dbReference type="OMA" id="PRGAQFE"/>
    <dbReference type="OrthoDB" id="1867415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021926">
        <property type="entry name" value="PipX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12058">
        <property type="entry name" value="DUF3539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="10735" checksum="F1C7ACDED6D350C0" modified="2013-03-06" version="1">MSTEIYINHPNFGLLYRLCVIDKNEELFTTLYAQRLFFKVVIQSQSPLFEPLSRTEARILMENKLRRLRGNGEWQTYQEVNKLYQNTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B7</accession>
    <name>K9Z0B7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218340.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0467"/>
    <dbReference type="EnsemblBacteria" id="AFZ52609">
        <property type="protein sequence ID" value="AFZ52609"/>
        <property type="gene ID" value="Cyan10605_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0467"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.495"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_3"/>
    <dbReference type="OMA" id="VWAVGKT"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30386" checksum="DB7B561928F036C6" modified="2013-03-06" version="1">MSNYRESYPLAGETILITRAYQSGNSFRQMLEAKGATVLEMPALEIKPPSSWQPLDKAINHIADFHWLILTSANGVEYFLERLHHLGKDINYLKNLKIAVVGKKTAHFLEKYNISPDFIPPDFIADSLVTHFPESIEGKKILFPRVETGGREILVQELTQQGGEVVEIPAYQSTCPDTIDNTVWDALVKEVISIITFASSKTVRNFHYLVTQALQTTPQLTLSSLLTEVAIASIGPQTSMTCQELLGKVDIEAQEYTLEGLVDSLVKKQYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R6</accession>
    <name>K9Z0R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218517.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0647"/>
    <dbReference type="EnsemblBacteria" id="AFZ52786">
        <property type="protein sequence ID" value="AFZ52786"/>
        <property type="gene ID" value="Cyan10605_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0647"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068399_0_0_3"/>
    <dbReference type="OMA" id="MSDINDS"/>
    <dbReference type="OrthoDB" id="806256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="30632" checksum="79BF2B99AD94D2D3" modified="2013-03-06" version="1">MTESSNAPKIPIREFIGTRQTTLFQSLKQPQFTGELIFGSSRGEEWIFYFYLGRIIFATGGRHPVRRWMRNVARFAPILITQISSLDESIINQKSFRQFWEYELLSYWLKQEEVTRQQLSLIIKNIIIEILFDITQRMEVVFQLRNNQSLSSQLVFIDPDQVIVEAWQSWQSWQNAKLADRFPNQCPIIRQYDKLQEKTSPKTYQIMSKLFNGKNTLRDLSLQINQDLTQITRSMLPYIQLGLVDLIDVPDIPCPINFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I4</accession>
    <name>K9Z1I4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218172.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0292"/>
    <dbReference type="EnsemblBacteria" id="AFZ52440">
        <property type="protein sequence ID" value="AFZ52440"/>
        <property type="gene ID" value="Cyan10605_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0292"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.303"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060706_0_1_3"/>
    <dbReference type="OMA" id="EETHITR"/>
    <dbReference type="OrthoDB" id="607377at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="138"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="45507" checksum="B5ACE5A7AA102077" modified="2013-03-06" version="1">MFQLPNIYQQHLKNQFNLPQYLTLYLLLNLLQNLKTIRLEEIARRFPYPIKLRSRVKKLQRFLSLKQWNINKVWFPIIKQWILQQWHRKTIIYLVIDRTQWGVINLLMVSLIYHHRAIPIYFQLLNKKGSSNFQEQKEVLAPSLNLLKDYKIVVLGDREFCSVDLAKWLLYQGKVYFALRLKKNEYIQISEIWTQLNELYLCPGMSCYYQGVKVTKSKGFTGASLVGKWRRKYRHKSSKEPWFLLTNLKSLPETISAYKKRMGIEEMFRDFKLGGYNLESTKVEGDRLIALLIIITLAYSWSTFSGEEIKRKGISEYLVRPKEKGRSDKRYSDFSIGFNGLNFLQGVSVFEEQWQELTSLFPQKSRYYRQGMRAIRLIQSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T8</accession>
    <name>K9Z1T8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ordered locus">Cyan10605_0995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218855.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0995"/>
    <dbReference type="EnsemblBacteria" id="AFZ53124">
        <property type="protein sequence ID" value="AFZ53124"/>
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</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="237" mass="26243" checksum="BC10A31092A0EC0E" modified="2013-03-06" version="1">MIAVEINNISFNYNQQQIFNDLCLTINNQEKVGIIGANGAGKTTLFLSICGILKLNQGEIKLFNKTIAAGKFHPEIGLVFQNPDDQLFCPTVKDDIIFGAENLGLSSSEIEARFNQVITTVGVKHLINRIPHQLSGGEKCMVAIASVLIMQPKIILYDEPSANLDLKARRKLIQFLQSSSETILVSAHDLELILEVCDRVIVMNKGKIIADGIPEKIMSDEKLMRENNLEIPPSLSR</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
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                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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    </dbReference>
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    </dbReference>
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            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="311" mass="35506" checksum="0D0BD8D79D60B593" modified="2013-03-06" version="1">MFFSVVIPTYNRLPILQKCLRALENQQFDTGLISDYEIVVVDDGSTDATISWLDTEKANLPHVRLFTQNHRGAGAARNLGVENAVGEYIIFIDSDLVVTESFLQSHAQALITAENKLQSDLIFTYGAVINTCNFDNPTSEPYKITDFSAAYFATGNVAIKKKWLIEAGMFDTMFSQYGWEDLELGVRLKRLGLKLIKCPSAVGYHWHPPFNLEQIPQLIEKEIERGKMGVLFYQKHPTYEVKMMIQMTWLHRLLWGILSLGGSLNEKTMKPLLQWLINQGKPQLALEIARIFLNWYNVQGVYDAYKLSKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y5</accession>
    <name>K9Z1Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218922.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1067"/>
    <dbReference type="EnsemblBacteria" id="AFZ53191">
        <property type="protein sequence ID" value="AFZ53191"/>
        <property type="gene ID" value="Cyan10605_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1067"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1129"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_3"/>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="29979" checksum="D1C02101F11F7C06" modified="2013-03-06" version="1" precursor="true">MDKFTNSTFKIFSFILLFGGLIIILSPFIFILYTSFFSTGTESKFTFQYYQLAWEKGNFLLAFANSGLVAIASVFFQVITSTLAGYALARLKFRGKNFIILLIISTLIIPFQVLVIPIFLILKWGHLINTYWALILPSAASGFGIFLMRQYFISIPVELEEAATLDGANSLQIIWQILFPLAKPAIITLSLFTFIGEWNDLFKPLVFTNTPNLTTVQLALASFQEQFTSNWSLLMAAVIIATIPVIILFIFGQKQFIQGVSDTGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z244</accession>
    <name>K9Z244_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218930.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1076"/>
    <dbReference type="EnsemblBacteria" id="AFZ53199">
        <property type="protein sequence ID" value="AFZ53199"/>
        <property type="gene ID" value="Cyan10605_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1076"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_1_3"/>
    <dbReference type="OMA" id="CAGNIEI"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="28872" checksum="B703DC8FFA17518B" modified="2013-03-06" version="1">MKVSIITVVYNNKSTIECAINSVLSQNYPKVEYIIIDGQSTDGTIEKIKPYQDRIDHFISEPDKGIYDAMNKGLKLATGDIVGILNSDDFYVNNSIISRIVSYFEKTRVDLVFGDIVYVNSQNLDKITRYYSSANFTPKKFAWGWMPAHPSCFLKRNIYEKYGYFKTDYQIAADYEILTRFIAKYNIRYAYIPEVFVKMRTGGKSTANLKSNLILNQEIVKACRENGIKTNIYKVFLKYFTKVFQLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z245</accession>
    <name>K9Z245_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bilirubin oxidase</fullName>
            <ecNumber evidence="6">1.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.3.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218995.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1144"/>
    <dbReference type="EnsemblBacteria" id="AFZ53266">
        <property type="protein sequence ID" value="AFZ53266"/>
        <property type="gene ID" value="Cyan10605_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1144"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1211"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_2_1_3"/>
    <dbReference type="OMA" id="GMWIIED"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047705">
        <property type="term" value="F:bilirubin oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="369"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="487" mass="54817" checksum="AE70748BC0F6808A" modified="2013-03-06" version="1">MKINRRQLLNLTLFATTAIIIKNLQQNSNQDTLWANELKPQIYKSKNGLLEVELIAQETPVNIDGKTAYLLTYNGQIPAPRLEAKAGDKVKIKFTNKLAQPTNIHYHGLHISPTGNADNAFLEIQPNQIFNYEFTIPDNHPSMTAWYHPHLHGYTAQQLSGGLAGLFIIRGELDDIPEINSAKEEFIVLQDFPLDNNGRLTDSRMMSLMMGREGDVITVNGEIKPQISLNKGEWLRLRILNASTSRFYNLSLDDNPFYLIATDGGAIASPQEMTRLLLTPGQRAEIMIKGENKQSSLKLINLPYNRGGMGMMGNGMMGGGMMGRRNNNSPQILATINLNQSNQNNQSVSLPNQLNTITALPSSSQVRSFTLNHGMANGMAFLINGKSYNHQRIDTEVKLNTVEEWELINTGMMDHPFHIHVNSFQVISRNDIPENLLAWRDTVLVKRGERVKIRIRFEDFTGKTVYHCHILDHEDLGMMGNLQINSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z256</accession>
    <name>K9Z256_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218538.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52807">
        <property type="protein sequence ID" value="AFZ52807"/>
        <property type="gene ID" value="Cyan10605_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0669"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.705"/>
    <dbReference type="eggNOG" id="ENOG5032VZE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195938_0_0_3"/>
    <dbReference type="OMA" id="PSHGWIF"/>
    <dbReference type="OrthoDB" id="1993912at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="8987" checksum="2984D9C6C68DA267" modified="2013-03-06" version="1">MNNFESRHSQPKLNNDEGWVVQVYGSNRRLLCVLEPSHGWIFLIGCGFGLLLSIIWFNVARYSPSLDTAPPVDSAPLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z289</accession>
    <name>K9Z289_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.18" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218578.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0711"/>
    <dbReference type="EnsemblBacteria" id="AFZ52847">
        <property type="protein sequence ID" value="AFZ52847"/>
        <property type="gene ID" value="Cyan10605_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0711"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.744"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_0_0_3"/>
    <dbReference type="OMA" id="AMRIKGE"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="5">
        <location>
            <begin position="97"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="39287" checksum="1EF7F42AF1253407" modified="2013-03-06" version="1">MSSEFRELLKKIGSGTHTHKNLTRQQASLALEMMLTGKATPAQIGGFMIAHRIKRPTGEELAGMLDAYSRLGNKLSIIDENKEVVVLGIPYDGRTRTAPISPITSLILSLMGVPVLMHGGRRMPTKYGLTLGEIWTNLGLNIQNTSLEQVQTSLAQKNFGFLYLPTHFPLADNFVTYREEIGKRPPIATLELIWHPYKGKNHIMAGYVHPPTEKMIREALTLTGVKKFTLIKGLEGSGDLKLEQTNIIAIDDHESEAGFKYLKLNPLHYGLKGHDYPLHSEQEYFEQLTKTIKGEMTPLTLSSIWNAGFYLWRCSVVETMEMGLSKAEELIMKGDLHNHCHSLSENLNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E3</accession>
    <name>K9Z2E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XisI protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219043.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1195"/>
    <dbReference type="EnsemblBacteria" id="AFZ53314">
        <property type="protein sequence ID" value="AFZ53314"/>
        <property type="gene ID" value="Cyan10605_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1195"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1261"/>
    <dbReference type="eggNOG" id="ENOG50314A7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149829_1_0_3"/>
    <dbReference type="OMA" id="GFQAPYK"/>
    <dbReference type="OrthoDB" id="1779248at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16382">
        <property type="entry name" value="XisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014968">
        <property type="entry name" value="XisI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035943">
        <property type="entry name" value="XisI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08869">
        <property type="entry name" value="XisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143847">
        <property type="entry name" value="SSF143847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12696" checksum="8A3E892E0A8013B0" modified="2013-03-06" version="1">MERIDYIQLVKDILTQHSINHSQNDTEIQLIFDDHNHHYQVLNIGWDDQTRIYGVIIHVDLKDDKIWIQRDGTEVGIANQLLDAGVAKEHIVLGFQAPYKREFTEFAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F5</accession>
    <name>K9Z2F5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219058.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1210"/>
    <dbReference type="EnsemblBacteria" id="AFZ53329">
        <property type="protein sequence ID" value="AFZ53329"/>
        <property type="gene ID" value="Cyan10605_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1210"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1277"/>
    <dbReference type="eggNOG" id="COG3914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022025_0_0_3"/>
    <dbReference type="OMA" id="PENAQDY"/>
    <dbReference type="OrthoDB" id="370520at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="327"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="521"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="725" mass="85191" checksum="3E592D97247EABC7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F8</accession>
    <name>K9Z2F8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218299.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0424"/>
    <dbReference type="EnsemblBacteria" id="AFZ52568">
        <property type="protein sequence ID" value="AFZ52568"/>
        <property type="gene ID" value="Cyan10605_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0424"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447378_0_0_3"/>
    <dbReference type="OrthoDB" id="162506at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="4">
        <location>
            <begin position="76"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="586" mass="68535" checksum="7A43C6E507E032EF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G6</accession>
    <name>K9Z2G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0616"/>
    <dbReference type="EnsemblBacteria" id="AFZ52755">
        <property type="protein sequence ID" value="AFZ52755"/>
        <property type="gene ID" value="Cyan10605_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0616"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.650"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="MHFTKPF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14791" checksum="FC14B2CE4CC7220C" modified="2013-03-06" version="1">MSVNQIMIKILVVDDNHTPREVISEALKQFNIQVTEASNGVEATKIIEKEKFNLVITDVVMPEMNGYELCRWIKSNPGTEKVPVIICSTKGEEFDIHWATKQGADAYIIKPFKTMELLKTIKYLLKHNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q7</accession>
    <name>K9Z2Q7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="3" type="synonym">rpl6</name>
        <name evidence="7" type="ordered locus">Cyan10605_0511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218384.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0511"/>
    <dbReference type="EnsemblBacteria" id="AFZ52653">
        <property type="protein sequence ID" value="AFZ52653"/>
        <property type="gene ID" value="Cyan10605_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0511"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.541"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_3"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19551" checksum="C346C2C6BDAD9318" modified="2013-03-06" version="1">MSRIGKRPITIPAKVEVTIDGQLVQVKGPKGDLSRTLPALVTLTQEGQEIKVVRDNDSRKARERHGLCRTLVDNMIQGVSQGFEKKLEIQGVGYRAQAQGSKLTLNVGYSKPVEMEMPQGISVAVNNNTEVVVSGIDKELVGNVAAKIRAVRPPEVYKGKGIRYSGEYVRRKVGKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R3</accession>
    <name>K9Z2R3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="8">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="8">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabZ</name>
        <name evidence="9" type="ordered locus">Cyan10605_0731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218596.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0731"/>
    <dbReference type="EnsemblBacteria" id="AFZ52865">
        <property type="protein sequence ID" value="AFZ52865"/>
        <property type="gene ID" value="Cyan10605_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0731"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.767"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_1_3"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17592" checksum="807C85D54802AB0E" modified="2013-03-06" version="1">MEQIAEQEKQSSIEKTTFTVQEIQELLPHRYPFALVDRILDYTPGEKAVGLKNVTINEPFFPGHIPGNPLMPGVLQLEALAQVGGVILTLLPGMKGKFFAYAGVDNARFRRPVVPGDQLIMTVELLSFKRNRIAKMQGRGLVDNQLAVEAQMLFSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V1</accession>
    <name>K9Z2V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0537"/>
    <dbReference type="EnsemblBacteria" id="AFZ52678">
        <property type="protein sequence ID" value="AFZ52678"/>
        <property type="gene ID" value="Cyan10605_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0537"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_16_0_3"/>
    <dbReference type="OMA" id="RHAHKGL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="16931" checksum="329D6A8376B292E9" modified="2013-03-06" version="1">MGKLEVTQHISFRVKSDLIYLKEVLSRFETLRQEWISEKDWLQSQLALAEAFTNAVRHAHKNKPPETIIEIEINISEEEIKIQVWDFGQPFQLESLKQRVNHQGEFATGGRGVEILQKIADDLRYDRISDNRNCLTIRKKLSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z301</accession>
    <name>K9Z301_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0972"/>
    <dbReference type="EnsemblBacteria" id="AFZ53102">
        <property type="protein sequence ID" value="AFZ53102"/>
        <property type="gene ID" value="Cyan10605_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0972"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1026"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_3"/>
    <dbReference type="OMA" id="HFDHNAV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938594" evidence="1">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="28300" checksum="66E6E86332A997A7" modified="2013-03-06" version="1" precursor="true">MSMKRRDWIRFTSCGLLTTFLALKYSPSSSAQNNTGVTIQWLGHSAFVFSNPQAKILVNPFTPLGCTAGYPKPNPEVEVVMISSRLLDEGSAAGLPNNPQLMVEPGVYQVKAIEFQGIKTFHDREGGRRFGDNVAWKWTQGGLKILHLGGIASPIDIEQRILMGSPDVLFVPVGGSAKAYNAQEAIAAIKALNPKVVFPTQYLTDAAEPGKCDLTRVDEFLELAKQEEDMGIKIIQGNQTTIKPQDLPPKGTLIRVFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z346</accession>
    <name>K9Z346_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219308.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1468"/>
    <dbReference type="EnsemblBacteria" id="AFZ53579">
        <property type="protein sequence ID" value="AFZ53579"/>
        <property type="gene ID" value="Cyan10605_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1468"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1557"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_3"/>
    <dbReference type="OMA" id="NQYVRLV"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="86"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="592" mass="67229" checksum="FEDEC1C6C178712E" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z363</accession>
    <name>K9Z363_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queF</name>
        <name evidence="2" type="ordered locus">Cyan10605_1483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219323.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1483"/>
    <dbReference type="EnsemblBacteria" id="AFZ53594">
        <property type="protein sequence ID" value="AFZ53594"/>
        <property type="gene ID" value="Cyan10605_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1483"/>
    <dbReference type="eggNOG" id="COG0780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102489_1_1_3"/>
    <dbReference type="OMA" id="LYINSYR"/>
    <dbReference type="OrthoDB" id="1675155at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027377">
        <property type="entry name" value="Nitrile_oxidored_QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="14705" checksum="B1AFB9A2AD6850BA" modified="2013-03-06" version="1">MTENQATEVKYGERAIEEGKLITFPNPRPGRVYNISVTLPEFTCKCPFSGYPDFATIYINYCPDEKVVELKAIKLYINSYRDRYISHEESINQILDDFVAAADPLSITIKGDFNPRGNVHTVVEVSHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E4</accession>
    <name>K9Z3E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF sensor signal transduction histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218976.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1125"/>
    <dbReference type="EnsemblBacteria" id="AFZ53247">
        <property type="protein sequence ID" value="AFZ53247"/>
        <property type="gene ID" value="Cyan10605_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1125"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1190"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_3"/>
    <dbReference type="OMA" id="VEDHYIN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="45633" checksum="63841EC942E35139" modified="2013-03-06" version="1">MKIAPLPNNESERIEALLRYDILDTEFEKAYDEITQLAAAICGTPVALISFIDGDRQWFKSKKGIEPRETPRNIAFCSHAILDTEIFIVEDASQDERFADNPLVLEDPPHIRFYAGAPLITPDGFALGTLCAIDSQPRCLTEEQLNSLRILAKQVVTQLELRLAMKTLQNYSQELKELNASKDKFFSIIAHDLKSPFNTILGFAEVLKNNALELTKEEIEELAGEIYNSGKNAFKLLQNLLHWSRLETGKMQINPEILNLNKLIEEVLLIVNPMAKEKNIQINTNFSTNNFTVKWDYNMLVSTIQNLLTNGIKFTPSGGQITIELEEKESQIQINIIDNGVGMTEKQLENLFKIDCCQTTEGTSGEIGTGLGLLLCKEFVEKNGGQIWVESQINQGSTFSFTIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E7</accession>
    <name>K9Z3E7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="13" type="synonym">atpH</name>
        <name evidence="15" type="ordered locus">Cyan10605_0770</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cellular thylakoid membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218634.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0770"/>
    <dbReference type="EnsemblBacteria" id="AFZ52903">
        <property type="protein sequence ID" value="AFZ52903"/>
        <property type="gene ID" value="Cyan10605_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0770"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.811"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_0_3"/>
    <dbReference type="OMA" id="NIATVGY"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="8003" checksum="D019885F934B96B5" modified="2013-03-06" version="1" precursor="true">MNPTIAAASVIAAALAVGLGAIGPGIGQGNAAGQAVEGIARQPEAEGKIRATLLLSLAFMEALTIYGLVVALVLLFANPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J9</accession>
    <name>K9Z3J9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease III</fullName>
            <ecNumber evidence="6">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nth</name>
        <name evidence="8" type="ordered locus">Cyan10605_1591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219426.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1591"/>
    <dbReference type="EnsemblBacteria" id="AFZ53699">
        <property type="protein sequence ID" value="AFZ53699"/>
        <property type="gene ID" value="Cyan10605_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1591"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1690"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_3"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="41"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="23822" checksum="FAEE52685EC9FAA0" modified="2013-03-06" version="1">MRISKKKKAIEILNILKQLYPTATCSLNYDTPLQLLVATILSAQCTDERVNKVTPALFKRFPDAQSFAQADREEIENLIRSTGFYRNKAKNIQNACIRIVNDFDGKVPQTMTELLTLAGVARKTANVVLAHAFGIIEGVTVDTHVKRLSNRLGLTKHSNPIQIEKDLMKLLPQAEWENFSISIIYHGRAVCNARKPRCPECTLSHLCPSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K7</accession>
    <name>K9Z3K7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfC</name>
        <name evidence="7" type="ordered locus">Cyan10605_0831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218694.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0831"/>
    <dbReference type="EnsemblBacteria" id="AFZ52963">
        <property type="protein sequence ID" value="AFZ52963"/>
        <property type="gene ID" value="Cyan10605_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0831"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.874"/>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_3"/>
    <dbReference type="OMA" id="GFVFKIH"/>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="14"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="534" mass="60504" checksum="7A903661D1F9C0DF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M8</accession>
    <name>K9Z3M8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms endoribonuclease Csm3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CRISPR type III A-associated RAMP protein Csm3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219076.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1228"/>
    <dbReference type="EnsemblBacteria" id="AFZ53347">
        <property type="protein sequence ID" value="AFZ53347"/>
        <property type="gene ID" value="Cyan10605_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1228"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1296"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067743_0_0_3"/>
    <dbReference type="OMA" id="NPVIKDP"/>
    <dbReference type="OrthoDB" id="1840881at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013412">
        <property type="entry name" value="CRISPR-assoc_RAMP_Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02582">
        <property type="entry name" value="cas7_TM1809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="316" mass="35601" checksum="85DA6E96CC5F74CA" modified="2013-03-06" version="1">MAQVIDKPQRNLLGKIIIKSDILVKTGLHIGGGAENLDIGGLDKSVIRDPITLQPYLPGSSMKGKLRSLLERMLNKPLNRSGGSGTYRYESDDTEDGYSDVQGNLVKFEGAKHCELSRVFGSTGKDCWIEKTVADSQQLDYKQTKTIEGKEYAKIKGRNYSARLIVRDAHLKADSAQRLQNIDTGLYMTEWKFENGIDRVTSAANPRQVERIPAGSVFEFEIVYTVEDETQVEKDLENIAIALKILEDDALGGHGSRGYGKINFTNFNIKYRTLDFYRQAITKKQEDKFLLDNIDNTDNLLERFQDVKGLLNPKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P0</accession>
    <name>K9Z3P0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0225 protein Cyan10605_1637</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0225 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219471.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1637"/>
    <dbReference type="EnsemblBacteria" id="AFZ53744">
        <property type="protein sequence ID" value="AFZ53744"/>
        <property type="gene ID" value="Cyan10605_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1637"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1738"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099590_0_0_3"/>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="OrthoDB" id="1472440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="18895" checksum="8C6B44FA107D13C8" modified="2013-03-06" version="1">MFISNHSLSSVPCPCGSQKPLNQCCDVYLQGQLPAPTAEKLMRSRYSAYCLKNIDYLFNTEHPKYRKPNSRAMITATANSLIWLGLTVLNTERGKSEDETGIVEFIAVYQEGKSVAQLHERSNFIKEKGKWYYTDGEILPPIQPKKNEPCWCNSGKKFKLCHGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P2</accession>
    <name>K9Z3P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219476.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1643"/>
    <dbReference type="EnsemblBacteria" id="AFZ53749">
        <property type="protein sequence ID" value="AFZ53749"/>
        <property type="gene ID" value="Cyan10605_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1643"/>
    <dbReference type="HOGENOM" id="CLU_2786923_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7501" checksum="3D99E6BADF4ED0C2" modified="2013-03-06" version="1" precursor="true">MDTKKLLKAISIFFLIIGALVIIISFGSGYPAFSIVGLSQMALAAFFFVIADLSEDVKEIKKILKNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q6</accession>
    <name>K9Z3Q6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0888"/>
    <dbReference type="EnsemblBacteria" id="AFZ53018">
        <property type="protein sequence ID" value="AFZ53018"/>
        <property type="gene ID" value="Cyan10605_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0888"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.933"/>
    <dbReference type="eggNOG" id="COG1738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_0_0_3"/>
    <dbReference type="OMA" id="IFQKFFY"/>
    <dbReference type="OrthoDB" id="1462872at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29700" checksum="31319711A6317CC3" modified="2013-03-06" version="1">MVEGLGVRASHSNEFDCFMLLIFNKSVKKLKRRKLIKSIFQMKQNFSSHQETIFLILSAIFIGCLICSNLIIQKFFTANIFSLNFELSVGIIPYPITFLCTDLISEIYGKNKANQVVIAGFISSLFILLIMTIANTVEAVSWSPISQETFNQVFGLFTPAVIASLLAYLVAQFVDIRMFHFWKNLTEGKHLWLRNNGSTIVSQLIDTSLVLFVLCIFGVIAWDKFSDLFLNGFTFKLLFALADTPFFYLGVWLIQPKLVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y4</accession>
    <name>K9Z3Y4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219571.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1741"/>
    <dbReference type="EnsemblBacteria" id="AFZ53844">
        <property type="protein sequence ID" value="AFZ53844"/>
        <property type="gene ID" value="Cyan10605_1741"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1741"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1848"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177584_0_1_3"/>
    <dbReference type="OMA" id="CMGSACH"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9651" checksum="694598FD802DACE7" modified="2013-03-06" version="1">MLKENLFLCMGSACHQLGVYEVLPKLQALMSEYNIDQIVELKGCFCLETCSSGIVMKFKDHLFINISPQNLEEKFIHEILPMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z412</accession>
    <name>K9Z412_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218849.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0989"/>
    <dbReference type="EnsemblBacteria" id="AFZ53118">
        <property type="protein sequence ID" value="AFZ53118"/>
        <property type="gene ID" value="Cyan10605_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0989"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1046"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_0_3"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="27447" checksum="147D39DD98EDA575" modified="2013-03-06" version="1">MTENKQAQPDNSQRFRTFFNLDLGSLKFLSNLRKETRQFAVIGLGRFGRAVCETLYNMGYDVLGADVEEKLVAQALTDKIASSAIRLDCTEASALKEAGIFELDTVIVAIGNYLEESIITTLNLKEAGVKYIVAKASSETHGKLLKKVGADLVVYPEYEAGCELAYTLTKPGILDRFELDPDNSIVEIAIPEEFDGKTLAEMKLRSRYGLNVLAVGNDDKFIINPPPQFVLTKGLSMVVIGSNKDINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z474</accession>
    <name>K9Z474_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1837"/>
    <dbReference type="EnsemblBacteria" id="AFZ53939">
        <property type="protein sequence ID" value="AFZ53939"/>
        <property type="gene ID" value="Cyan10605_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1837"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1950"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037171_0_0_3"/>
    <dbReference type="OMA" id="VICDSIQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="41802" checksum="89F7124D5E875CC2" modified="2013-03-06" version="1">MQSIFNFEQFINYELLKNIYEGWQKIKAGLSLAHKNFSTEVRQRIFPYELPLEKVSSETWTVLQARLDQIIEEDWQDAKEGVYPINLLFDTDWGKFLQAYIGIWFDYPQTWQRIKNNHFQDLPPNIDSNKYPQYYRRNFHYQTDGYLSEHSANIYDLQVDILFNGVTDAMRRRILKPLKQGLNTLNSSSNPKILDVACGTGRTLKFIRATFPHASLYGIDLSAPYLRKANELLSQLPQELPQLVEGNGEELPYQDNYFQGVTSVFLFHELPNPVRQKVINECYRVLQAGGICIFADSMQLSDSPELETMMTNFPIAFHEPFYNDYIRDDLKSRLNVAGFRNIREEVHGFSKYWIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B2</accession>
    <name>K9Z4B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218929.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1074"/>
    <dbReference type="EnsemblBacteria" id="AFZ53198">
        <property type="protein sequence ID" value="AFZ53198"/>
        <property type="gene ID" value="Cyan10605_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1074"/>
    <dbReference type="eggNOG" id="ENOG502ZAHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073820_4_0_3"/>
    <dbReference type="OMA" id="MESALPC"/>
    <dbReference type="OrthoDB" id="1180333at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="61"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="27097" checksum="3B05D80DAA7C0866" modified="2013-03-06" version="1">MFKISESTAHNIFHKWQKCMESALPCSLLEQVKKSEENLEEMEQILTHYELIVDSEEQEIERSLDYEQQKKHTFKNQIICLPRGEDIVDVVAGEQGRKADITIWRENANKFDEKQKFSGDKAYVGEPQIRTPKKKPKNGELTQEEKEQNKEISSERIFVEHLIRIIKVFKVMGERFRLKKEEYESVFLSVCGLVRLRMKTLIIKYQKKKEIGEVIDVLLTHIFSSKLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C9</accession>
    <name>K9Z4C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219771.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1950"/>
    <dbReference type="EnsemblBacteria" id="AFZ54046">
        <property type="protein sequence ID" value="AFZ54046"/>
        <property type="gene ID" value="Cyan10605_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1950"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2072"/>
    <dbReference type="eggNOG" id="COG3372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038336_0_0_3"/>
    <dbReference type="OMA" id="VMIPDFR"/>
    <dbReference type="OrthoDB" id="1178381at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019435">
        <property type="entry name" value="UCP019435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="407" mass="47072" checksum="AD417B481198B9CD" modified="2013-03-06" version="1">MLKSDLLIYRYSGETIVPKKLPLQPRFIDLAWEQIDCFESYLGKTQGELDAKLQELEGDSPDYRVKRGLAHLLKSNFSQFNIVSPLEPQILRKKVFEAAAKLPSIPQNRSKTLDAIASSLTAELHREVLPQEIEKGLYADLLENRILTEFDAPSPETLIHRYNLSQVQGIFYRASHILIHAHRNDPGEYKLLFRYLKLFQLMAYIEGDADTGFTITIDGPTSLFKVSNRYGLALAKMIPALLHVSKWKLEAKLKIKDFYSKREKIGHFYLDDNCGLVTHYANNKTYDSLLEESFAKGWEKLKTPWRLEREVDLIPLPGSVMIPDFRLVHPDGRDFLLEIVGYWRPEYLQKKFYQVRRAETNNLILAVSERLNLAKAGVNFKDLPHKLIWFKNKLSPKEVLNILPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J2</accession>
    <name>K9Z4J2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219032.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1182"/>
    <dbReference type="EnsemblBacteria" id="AFZ53303">
        <property type="protein sequence ID" value="AFZ53303"/>
        <property type="gene ID" value="Cyan10605_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1182"/>
    <dbReference type="eggNOG" id="COG5266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105325_0_0_3"/>
    <dbReference type="OMA" id="MAACVIW"/>
    <dbReference type="OrthoDB" id="1951937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19215" checksum="DE475DB2AFD035D3" modified="2013-03-06" version="1" precursor="true">MKLRTLSNLGLGLVLASVIHQPKTSAHGVAIDYQATEAIAIQAKYDSGKPMSNAQVVVYAPNNPTQAWQTGVTDSDGKFTFVPEPNVNGNWTIKVRSAGHGSVVNIPIEPLQAENDHQIQEEISENPNTNLGQSPRASSSITGELSTPQKILMALTGSWGFVGTALFFSRKKQESKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J7</accession>
    <name>K9Z4J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219037.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1189"/>
    <dbReference type="EnsemblBacteria" id="AFZ53308">
        <property type="protein sequence ID" value="AFZ53308"/>
        <property type="gene ID" value="Cyan10605_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1189"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538312_0_0_3"/>
    <dbReference type="OrthoDB" id="1444763at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="506" mass="58551" checksum="0286993E7398ED1C" modified="2013-03-06" version="1">MTANLITFPDWTQPEDLLYQDLVNLIKKVSNFENTNLLIDITGISQEEAELMFSSVITSLTLEEGLEISDSLGLNFVSEITPDIFSNLQKDNYKIVNLNSSGQNNLNKEYKSVRKHYNLIYEKQGYIPVELAIFDTIHPKTPIIGGFRHAEHSYYLEHFTNSICIHGNSRTYKTWEEIKRAINKYCHFLQKPLWRNKFYVINEVGILKPELAYSLMVNETLNFLPIFEKFKIPFCACITPGGGFFLDNEISDINCRRIVESPSFRYLITTQEIINDYLLKKIPSLKGRSEAIYGGFSQIEANEIKTRPDVCHKKRLDIAFVAYNYGNNGFDKGFDIFCDVVTKSLFSTDSKFRFHIVGNWDYENISFAPKPSQEVIYHGVLSRDELIDLYPYIDIILNPYRLLNDGQFNGFPMSPDGSMCGCALFSTNPLRLKTPYISGQDVVEITENSQDIFDLLIYYDQHRDKLKNLAIKGQEKTLLYRSRTAQAEKRIQIFERLIGHKMERQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S6</accession>
    <name>K9Z4S6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photosystem II reaction center protein M</fullName>
            <shortName evidence="8">PSII-M</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">psbM</name>
        <name evidence="9" type="ordered locus">Cyan10605_1615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cellular thylakoid membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PsbM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219449.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1615"/>
    <dbReference type="EnsemblBacteria" id="AFZ53722">
        <property type="protein sequence ID" value="AFZ53722"/>
        <property type="gene ID" value="Cyan10605_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1615"/>
    <dbReference type="eggNOG" id="ENOG50339PB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215415_0_0_3"/>
    <dbReference type="OrthoDB" id="2087962at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00438">
        <property type="entry name" value="PSII_PsbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007826">
        <property type="entry name" value="PSII_PsbM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037269">
        <property type="entry name" value="PSII_PsbM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05151">
        <property type="entry name" value="PsbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161033">
        <property type="entry name" value="SSF161033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03038">
        <property type="entry name" value="PS_II_psbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="2 8" id="KW-0674">Reaction center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="34" mass="3782" checksum="70ABAFBD72A09B5D" modified="2013-03-06" version="1">MQVNDLGFVATILFVLVPTVFLLILYIQTGKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T0</accession>
    <name>K9Z4T0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ordered locus">Cyan10605_1620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219454.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1620"/>
    <dbReference type="EnsemblBacteria" id="AFZ53727">
        <property type="protein sequence ID" value="AFZ53727"/>
        <property type="gene ID" value="Cyan10605_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1620"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1720"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_2_3_3"/>
    <dbReference type="OMA" id="IGKHLFE"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:shikimate kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20938" checksum="B94811E44C9EB1DB" modified="2013-03-06" version="1">MKELLKGLNIYLIGMMGSGKTTVGELLAKELEYRFLDTDAIISAVSEKSINQIFAEDGEDEFRQLESDVLQEVSAYLYTVIATGGGIILRQQNWSHLRDGMVVWLNVPIDVLVQRLKDDDTRPLLKREELQTKLTSLYEQRKSLYQQADITIGIEENDNPNDIVQKIMVEIPHKIRQENSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T6</accession>
    <name>K9Z4T6_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">ArsC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ54159.1"/>
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        <property type="gene ID" value="Cyan10605_2070"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1393">
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Arsenate_reductase-like"/>
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    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13583" checksum="738DDC5316D9C194" modified="2013-03-06" version="1">MTLYVYGIPNCGTCKKAIQWLEENNVTYQFINTKENPPQEKMIKEWVNTLGVKSMRNTSGMSYRALGEEKNSWTEADWIKAFAKDAMLLKRPLFVKNNQAVLVGFRANEAVKKEKLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V6</accession>
    <name>K9Z4V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219494.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1661"/>
    <dbReference type="EnsemblBacteria" id="AFZ53767">
        <property type="protein sequence ID" value="AFZ53767"/>
        <property type="gene ID" value="Cyan10605_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1661"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1763"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181616_0_0_3"/>
    <dbReference type="OMA" id="CHACTVE"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="8515" checksum="8491F912FF930569" modified="2013-03-06" version="1">MTTVKVTFLPDNVTVEAETGEPLLDVAKRGNVFIPTGCLMGSCHACEVELDDGTPICACISSVPSGIEELTINLYSDPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z523</accession>
    <name>K9Z523_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219242.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1401"/>
    <dbReference type="EnsemblBacteria" id="AFZ53513">
        <property type="protein sequence ID" value="AFZ53513"/>
        <property type="gene ID" value="Cyan10605_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1401"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1480"/>
    <dbReference type="eggNOG" id="ENOG50331UT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174720_0_0_3"/>
    <dbReference type="OMA" id="RICKHMN"/>
    <dbReference type="OrthoDB" id="1919863at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10231" checksum="552DA3718A624E70" modified="2013-03-06" version="1">MSETITTAVSDRICKHMNDDHGDALVLYAKHYGNLENLNSAKMLSIDNKGMLLIIDNNEEKPLRINFDHTLIDAKDAHHTLVEMLKSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z532</accession>
    <name>K9Z532_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit K</fullName>
            <shortName evidence="1">NDH-K</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndhK</name>
        <name evidence="5" type="ordered locus">Cyan10605_1411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cellular thylakoid membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219252.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1411"/>
    <dbReference type="EnsemblBacteria" id="AFZ53523">
        <property type="protein sequence ID" value="AFZ53523"/>
        <property type="gene ID" value="Cyan10605_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1411"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1491"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_2_1_3"/>
    <dbReference type="OMA" id="TMKMAPQ"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="85"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="27142" checksum="F92D119B71FF7803" modified="2013-03-06" version="1">MNTSATDLKNLENQAKEKILNPAARSQVTQDLSENIILTTVDDLHNWARLSSLWPLLYGTACCFIEFAALIGSRFDFDRFGLVPRSSPRQADLIITAGTITMKMAPALVRLYEEMPEPKYVIAMGACTITGGMFSSDSTTAVRGVDKLIPVDVYIPGCPPRPEAIFDAIVKLRKKVANESIQERGTVRSQINRYYSTTHNMKAVDPILTGKYIRSESRNNPPAELAAAMGMPVDTAKLTEKTQKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z590</accession>
    <name>K9Z590_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220034.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2223"/>
    <dbReference type="EnsemblBacteria" id="AFZ54309">
        <property type="protein sequence ID" value="AFZ54309"/>
        <property type="gene ID" value="Cyan10605_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2223"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2362"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_3_2_3"/>
    <dbReference type="OMA" id="MKVNLHT"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="23073" checksum="39057EBECE57BDAE" modified="2013-03-06" version="1">MSVPTQNTESTPNNVVTKSQKSPAKPFKLWQDIQSHQEVRIEIVPMIDVIFCILTFFILAAVGFSRQQAISLNLPKAVTGTPQMREILVVSLDNQGQLYLEKQPVSQVQLYSAIKNYHSLNPTGLMVLHASQDVRYSEVIEVLDMLKEVGGDRVALATLAGKSNAPTQTVDPYSGFNPYYPSPNPSNPTAPPMPSQPPSPSAPPSPEGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B3</accession>
    <name>K9Z5B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219659.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1830"/>
    <dbReference type="EnsemblBacteria" id="AFZ53932">
        <property type="protein sequence ID" value="AFZ53932"/>
        <property type="gene ID" value="Cyan10605_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1830"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1942"/>
    <dbReference type="eggNOG" id="ENOG502ZYMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130859_0_0_3"/>
    <dbReference type="OMA" id="VIIRNQP"/>
    <dbReference type="OrthoDB" id="1716054at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025480">
        <property type="entry name" value="DUF4330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14221">
        <property type="entry name" value="DUF4330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="175" mass="18714" checksum="9E178DC37E9108FE" modified="2013-03-06" version="1">MKIIDSKGRLFGKISILDLGAIAVIVLVLIGIFIVPGPKGSIAQVGSGGDTIELNLLVRGLSVKNPQEFLRSLENSSVKIIVRNEPAGNLNIESVEELPNYVVATQPDGSVKSLLDPRPIVALSTDMILYMNGKGSMTNDGAILANQKVKIGTVLELDGSNYNFRGSVIDVRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C9</accession>
    <name>K9Z5C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219674.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1845"/>
    <dbReference type="EnsemblBacteria" id="AFZ53947">
        <property type="protein sequence ID" value="AFZ53947"/>
        <property type="gene ID" value="Cyan10605_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1845"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1958"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106290_0_0_3"/>
    <dbReference type="OMA" id="VWALGNC"/>
    <dbReference type="OrthoDB" id="1529205at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="27443" checksum="F8E1AFE3C5909586" modified="2013-03-06" version="1">MNDLSLKQTAIDFDSDLDPLDDIEVESSPAPDPELMLQLIRSDNKQEQIQAVRAFCEISEPRAIPILIEFLNNSCPLIRVSSAYALGRNTDESAVVPLINTLKNDWNGYVRKGIVWALGNNGDERAFEPLLNALKTDISAVRLWAASSLANIAKLNYEDTITALPVLIKALRQDEVPAVRSNCGWTIGQLCRELPYNVVYATAIDALIEALVEDKDLGVKEDAKMALLRLGDPRGLQMIEELELEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D4</accession>
    <name>K9Z5D4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RTX toxin-activating lysine-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in fatty acylation of protoxin at internal lysine residues, thereby converting it to the active toxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RTX toxin acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219340.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1503"/>
    <dbReference type="EnsemblBacteria" id="AFZ53613">
        <property type="protein sequence ID" value="AFZ53613"/>
        <property type="gene ID" value="Cyan10605_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1503"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1594"/>
    <dbReference type="eggNOG" id="COG2994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116529_1_0_3"/>
    <dbReference type="OMA" id="WLWMHSP"/>
    <dbReference type="OrthoDB" id="1823499at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009404">
        <property type="term" value="P:toxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003996">
        <property type="entry name" value="RTX_toxin-activating_protC_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02794">
        <property type="entry name" value="HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="17367" checksum="FD3C301840703C62" modified="2013-03-06" version="1">MSISDIAINENMTKILGEIVFLMGSCDNSRKYPISFIINYLLPSIHLNQYRLYRTVKENKPIGFACWAFVSDQVEEQMIKNDINLTIEERKSGENLYILYFIAPFGHAKKISQDLKNNIFPYRMIKGLRLTKDSKKIAKIAIYHNRNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F8</accession>
    <name>K9Z5F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220145.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2337"/>
    <dbReference type="EnsemblBacteria" id="AFZ54421">
        <property type="protein sequence ID" value="AFZ54421"/>
        <property type="gene ID" value="Cyan10605_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2337"/>
    <dbReference type="HOGENOM" id="CLU_210200_0_0_3"/>
    <dbReference type="OMA" id="QIIERVW"/>
    <dbReference type="OrthoDB" id="2024437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="7094" checksum="11A52B215DD1A29F" modified="2013-03-06" version="1">MIYQNNYKLEHITEPINKAEPEIKLIVEQVLQLEKDKLSQKNSRYINEDILNIIRNNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G8</accession>
    <name>K9Z5G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219532.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1702"/>
    <dbReference type="EnsemblBacteria" id="AFZ53805">
        <property type="protein sequence ID" value="AFZ53805"/>
        <property type="gene ID" value="Cyan10605_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1702"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_16_4_3"/>
    <dbReference type="OMA" id="REHFLFA"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14397" checksum="EEF64CDA9FABF634" modified="2013-03-06" version="1">MLEPSEVVDLFFNHLPVKTFQPGEVIFRQGEKGNCMFALMSGEIELRKDDQVVETIHQHDVFGEGALVQPEHNRCTTAIALTECKIAELNRERFLFLLQETPLFSLEIVRSLSSRLRKVKQKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I1</accession>
    <name>K9Z5I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NHPM bacteriocin system ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219547.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1717"/>
    <dbReference type="EnsemblBacteria" id="AFZ53820">
        <property type="protein sequence ID" value="AFZ53820"/>
        <property type="gene ID" value="Cyan10605_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1717"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1824"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_95_5_3"/>
    <dbReference type="OMA" id="VRRQCGV"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022515">
        <property type="entry name" value="NHPM_micro_ABC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03797">
        <property type="entry name" value="NHLM_micro_ABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="423"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="743"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="777"/>
            <end position="784"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="978" mass="108040" checksum="623483DBC1FFE49D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I9</accession>
    <name>K9Z5I9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219732.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54007">
        <property type="protein sequence ID" value="AFZ54007"/>
        <property type="gene ID" value="Cyan10605_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1909"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2026"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122700_1_0_3"/>
    <dbReference type="OMA" id="IDWANFT"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="140" mass="14758" checksum="B07A38A6F5F5259A" modified="2013-03-06" version="1" precursor="true">MTIASSWIYGLMGGILIGVSASILLAFNGRIAGISGMINGVLEFSPTQRWRWYFLGGMIAGGFIYEYILPLPSTPASGVAVIPMILGGLLVGWGTRMGNGCTSGHGVCGLGRLSMRSLVSVISFLASGMITVYITRHLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M3</accession>
    <name>K9Z5M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family UPF0150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220173.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2366"/>
    <dbReference type="EnsemblBacteria" id="AFZ54449">
        <property type="protein sequence ID" value="AFZ54449"/>
        <property type="gene ID" value="Cyan10605_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2366"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2512"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_10_3_3"/>
    <dbReference type="OMA" id="QQFTAII"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8376" checksum="C99360654339397D" modified="2013-03-06" version="1">MKYKQLTAIIEKEGDGYVSLCPELDIVSQGDTIEEARNNLKEALELFFETASSQEIDTRLHNEVYITRLEVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N6</accession>
    <name>K9Z5N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative tyrosine transporter P-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220188.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2381"/>
    <dbReference type="EnsemblBacteria" id="AFZ54464">
        <property type="protein sequence ID" value="AFZ54464"/>
        <property type="gene ID" value="Cyan10605_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2381"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2528"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_3"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="47937" checksum="2773D4CC8700B909" modified="2013-03-06" version="1">MSELSSIISASVFVIVIILIMSEKLHLTIAALLGALILIFTHTITLTEAVEFISKSHATLVLFFGVMVLIRAFEPTKIFEYIATKMVIIAKGRGKVLILGIIGITTPICAVLPNATTVMLLAPLIPPLAEEIGVNFVPLLILMVFVANSAGLITLVGDPATFIVGDAINMTFLEYLQKLTLGGIIAVVSVAIVAPLLFRKIWNTKFTHLEDLPHPQVNHPRMLILGALIMVFVLTFFVIGDSLAVPISPASVALLGATLALLLAHHSKIDTVHNILRDVDWSTLIFFMSIFVLIGSLEKTGVVSHLSGILALVLGKNIFVGSILLVFVVGILSSVVPNIPLVVAMVPLLKEYLVNVNLVDSSILDPNYTGQLPPEVLPLFYAMMFGATLGGNGTLVGASSNIVAAGIAEQHGKIISFHTFLKYGLPIMTVQLFISSIYIGSFWLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T5</accession>
    <name>K9Z5T5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219662.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1833"/>
    <dbReference type="EnsemblBacteria" id="AFZ53935">
        <property type="protein sequence ID" value="AFZ53935"/>
        <property type="gene ID" value="Cyan10605_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1833"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1945"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924163_0_0_3"/>
    <dbReference type="OMA" id="CQKTWGD"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="90"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="301" mass="34798" checksum="486F1868E30BE27E" modified="2013-03-06" version="1">MTFFVTNHHLSQTTENILEKTWQKFPSLKKNNIALTVVMENKEKSPLQGFSYRGNEKIYPASIVKLFYLVAVEEWLNQGKIQPSSEFDRAVRDMIVESSNDATSLVMDTLTQTTSGYELPELEFLQWQKQRNMINDYFQNYNWEEFASINVNQKTWCDGAYGRERIFLGENYENRNMLTTNAVARLLYSIMNNLVVTEKACEKMRNLLKRDASKKKIGINDEENQINGFIGESVPNNAQIWSKAGWTSQVRHDCAYITLPNSTSYLLVIFAEGKATRQRNLIPFISHQFIMEIQKIGALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U7</accession>
    <name>K9Z5U7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220284.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54561">
        <property type="protein sequence ID" value="AFZ54561"/>
        <property type="gene ID" value="Cyan10605_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2480"/>
    <dbReference type="HOGENOM" id="CLU_2786924_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="8037" checksum="8A8C50E0D294CF4B" modified="2013-03-06" version="1">MWKALISLIIFITAGYWFVNQYLSQQSSEPTPEEKAKENKVVEEYKDKLNENLEKGSERFKNLDPQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z611</accession>
    <name>K9Z611_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220349.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2546"/>
    <dbReference type="EnsemblBacteria" id="AFZ54626">
        <property type="protein sequence ID" value="AFZ54626"/>
        <property type="gene ID" value="Cyan10605_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2546"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377514_0_0_3"/>
    <dbReference type="OMA" id="CLMPDAI"/>
    <dbReference type="OrthoDB" id="1571420at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="23255" checksum="33EF0EEA8FD4F894" modified="2013-03-06" version="1">MKKQDWLVDNNGVCLPLKILSIPSKTASVYRLYRFLTDLEDILETIQDDEKRLGAIAPLMRKLLNESPWLYLSMLEPNPDTGWEIMTLYDEPSFPLTVQLVAWAGGTVSPIHNHGCWGIVALLEGKEKNTFWRRNPQPNQPDKIEKVGEKILTEGDILCFSADAIHHIEAMGNQPTISFNLYGETDYDRRFEFNARENTAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z692</accession>
    <name>K9Z692_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219820.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2001"/>
    <dbReference type="EnsemblBacteria" id="AFZ54095">
        <property type="protein sequence ID" value="AFZ54095"/>
        <property type="gene ID" value="Cyan10605_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2001"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075506_0_0_3"/>
    <dbReference type="OMA" id="CANLENC"/>
    <dbReference type="OrthoDB" id="1468268at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="37642" checksum="65BB96AED22C6176" modified="2013-03-06" version="1">MDKIVTKKDRNDNTIILLKYSKGKRNFRKQNFAGINLSGLSLIDIDLSETDLSCANLENCDLRGANLSKSCLKGSNLKGCNLRGAILNEADLSYGNLNHVNLTKARCKKTNFYRSHISSANLQNSYFSEANLVATSLNKSDLSYGNFQKANLNHGFLTGSNLTRTNFQEANLTNACLIRAIIDKTLFQGAEYNLQTLFDHHFLPEKHGMSEGGYISVAEIVNSLNYLSKTGSHYLGKSIIVKYLEKSRPHCEWVNSFKITNKGSIHYQGALTEIISDFELKWYQEWVKNYIQNCSIMVKGFIDLLEQDKIFLQQDKIVSPQYLNYNLEQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z695</accession>
    <name>K9Z695_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="4" type="synonym">rpl32</name>
        <name evidence="5" type="ordered locus">Cyan10605_1826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219655.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1826"/>
    <dbReference type="EnsemblBacteria" id="AFZ53928">
        <property type="protein sequence ID" value="AFZ53928"/>
        <property type="gene ID" value="Cyan10605_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1826"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1937"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199882_0_0_3"/>
    <dbReference type="OMA" id="RKAHWKR"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044958">
        <property type="entry name" value="Ribosomal_L32p_plant/cyanobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36083">
        <property type="entry name" value="PTHR36083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="6648" checksum="56A9E85625B960B9" modified="2013-03-06" version="1">MAVPKKKTSKSKRNQRRAHWFKKAELQAQRALSLGKSVLTGKANGFVYPTKEEEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z696</accession>
    <name>K9Z696_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ordered locus">Cyan10605_2589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220387.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2589"/>
    <dbReference type="EnsemblBacteria" id="AFZ54664">
        <property type="protein sequence ID" value="AFZ54664"/>
        <property type="gene ID" value="Cyan10605_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2589"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2750"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_3"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
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        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="512" mass="55319" checksum="D46703E1B944A5BB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K7</accession>
    <name>K9Z6K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1942"/>
    <dbReference type="EnsemblBacteria" id="AFZ54038">
        <property type="protein sequence ID" value="AFZ54038"/>
        <property type="gene ID" value="Cyan10605_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1942"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2064"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_3"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="42666" checksum="AD7CF208B546D437" modified="2013-03-06" version="1">MKIPILDLKPQYQSLKGEIDSAIASVLESTQFVLGSEVTALETEIADYLGVKHAIGVNSGTDALVIALRALNIGAGDEVITTSFSFYATAESISIVGATPIFADISTTTFNIDASSILEKITPKTKAIIPVHLYGQPAAMGKIQEIAKQHNLKVIEDCAQAFGAIYYGDCPDCQENCQKPLRDSLVGKYVGNLGDFGAYSFYPTKNLGAYGDAGMIVTNDDELAELAKMLRVHGSKKNYHNELLGYNSRLDSLQACILRVKLKYINQWNQTRQKVAEIYNHLLANNENIITPNISKGHVFHQYTIRVINGKRDQLKEYLAQQGIGSMIYYPIPQDQLPVYKDKYYPNPISMKLAQEVLSLPIYPELTQENIEFVAQTINDFFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N7</accession>
    <name>K9Z6N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative heterodisulfide reductase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220578.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2789"/>
    <dbReference type="EnsemblBacteria" id="AFZ54856">
        <property type="protein sequence ID" value="AFZ54856"/>
        <property type="gene ID" value="Cyan10605_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2789"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2964"/>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093432_1_0_3"/>
    <dbReference type="OMA" id="RTYGRQY"/>
    <dbReference type="OrthoDB" id="1319322at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22426" checksum="487E6701FBFC6A7F" modified="2013-03-06" version="1">MITKKKKFVFGMKKDRQLDGDKMNLDFAKRVEAEGGKGSAIAACMQCGTCSGGCTNIDVMDMSPRTLILMIQRGEWEKVLQSNTLWMCSSCYICTSRCPRGVRPSDVIEAVKAIAIEEGIKNDSTKFNQIFVDLVQKRGILFEPELMQRFGGLQAMIDQAPLGIQLVLRGKMSPFPEKIKNPQQFSQALDKARKKHENND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R5</accession>
    <name>K9Z6R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220551.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2761"/>
    <dbReference type="EnsemblBacteria" id="AFZ54829">
        <property type="protein sequence ID" value="AFZ54829"/>
        <property type="gene ID" value="Cyan10605_2761"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2761"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2932"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_1_0_3"/>
    <dbReference type="OMA" id="PYTHPIL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="8"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="749" mass="87681" checksum="A2F3FA8FC12699A5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V0</accession>
    <name>K9Z6V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220010.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2199"/>
    <dbReference type="EnsemblBacteria" id="AFZ54285">
        <property type="protein sequence ID" value="AFZ54285"/>
        <property type="gene ID" value="Cyan10605_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2199"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2337"/>
    <dbReference type="eggNOG" id="COG4665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086356_2_2_3"/>
    <dbReference type="OMA" id="WNVVGRY"/>
    <dbReference type="OrthoDB" id="2073326at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="20386" checksum="56104D3B853314E1" modified="2013-03-06" version="1">MGIALKISKIIDNISEWCGKISYGLVLVMIALGVWNVLGRYIGKIFGENLSSNSFIELQWYVFDIIFFLGAAYALKVDSHVRVDLFYKDFSPKLKALVNILGVVLFVFPFCGVVIYFSWQYVANSWQIWEISADEGGLPRYPIKTMILVSPFLLILQGISEIIKNLDIFLNNSSVKVNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z725</accession>
    <name>K9Z725_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2939"/>
    <dbReference type="EnsemblBacteria" id="AFZ55001">
        <property type="protein sequence ID" value="AFZ55001"/>
        <property type="gene ID" value="Cyan10605_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2939"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3127"/>
    <dbReference type="eggNOG" id="COG4402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036701_0_0_3"/>
    <dbReference type="OMA" id="LPIRLGM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019283">
        <property type="entry name" value="DUF2330"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016838">
        <property type="entry name" value="UCP026449"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10092">
        <property type="entry name" value="DUF2330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026449">
        <property type="entry name" value="UCP026449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="54523" checksum="7B98601D908CDDC6" modified="2013-03-06" version="1" precursor="true">MGDKLGKGKGKKWTYRNKQIFIKISLKKMKKILTLISLLLIIFLCFPSSVLAFCGFYVAKADSKLYNQASQVIIARNGNPQGGTFGERTVLTMANDYQGNVKDFALVVPVPVPIKEDQVNVGNPKIIERLDAFSAPRLVEYFDNDPCQPVYLMDNMPSAAETTRGGRNQMQKNETFGVTVESKFTVGEYDIVILSAKESDGLEKWLISNGYNIPKGAKELLQPYIRQKMKFFVAKVNLTELSKSDYQSLRPLMIAYESPKFMLPIRLGMVNSKQAQDLIVYLLSGEGQTELTNYRTVKIPSNVDIPEFVEKQFADFYKSMFTRSYEKEGKKVAFLEYAWNMGNCDPCSAEPLNPEELKQAGVFWYNPRGFNDLFITRLHIRYDRTHFPEDLKFQNTSNQQLFQGRYVIRHPYREKITCDAGQEYHKQTRERQEKEAQTLANLTGWNLAKIKQQIDFIKPENASLPWWRKLWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z742</accession>
    <name>K9Z742_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219908.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2094"/>
    <dbReference type="EnsemblBacteria" id="AFZ54183">
        <property type="protein sequence ID" value="AFZ54183"/>
        <property type="gene ID" value="Cyan10605_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2094"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144044_0_0_3"/>
    <dbReference type="OMA" id="ARECGYY"/>
    <dbReference type="OrthoDB" id="1684892at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027360">
        <property type="entry name" value="AbrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42182">
        <property type="entry name" value="PTHR42182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14250">
        <property type="entry name" value="AbrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="13922" checksum="28355DF0C82FA72A" modified="2013-03-06" version="1">MRNKKVQPLTGKDLLKKVKKLGNVSREEKAIECGYYTLTDNGQKRVSMVKFLNALIEAEGISLDNELPTESKKRGRSANYRINVQSNGNLSIGKAYTEKMGLKPGDEFEVILGRKNIHLKQIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z743</accession>
    <name>K9Z743_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2959"/>
    <dbReference type="EnsemblBacteria" id="AFZ55021">
        <property type="protein sequence ID" value="AFZ55021"/>
        <property type="gene ID" value="Cyan10605_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2959"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3149"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_3"/>
    <dbReference type="OMA" id="HCIHHDA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33763" checksum="F1DA281010968E35" modified="2013-03-06" version="1">MNNYQQWQWQGFNIAYQQCGEKGASVVFIHGFGANSGHWRHNLKVIGENYCCYAIDLLGFGASDKPLPNQPLSYTFETWAKQVGDFCREVVKTPVILVGNSIGCVVTMQTAVDYPDLVTKIAAFNCSLRLLNERKRLTLPWYRNLGATVMQKVLTNRAIASYFYNQIAKPQVIRKILTQAYKKQEAITDELIEIIYKPSQDKGAVDVFVAFTGYSSGPIPEDLLPILPCPITFFWGAEDPWESIELGRELANYPCVEDFIELEGLGHCPQDEAPEIVNPLLLNWLETSSPKLNEKSIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z778</accession>
    <name>K9Z778_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220320.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2516"/>
    <dbReference type="EnsemblBacteria" id="AFZ54597">
        <property type="protein sequence ID" value="AFZ54597"/>
        <property type="gene ID" value="Cyan10605_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2516"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072193_2_0_3"/>
    <dbReference type="OMA" id="MRQEGKI"/>
    <dbReference type="OrthoDB" id="1705064at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021788">
        <property type="entry name" value="CPP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33372">
        <property type="entry name" value="PTHR33372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11833">
        <property type="entry name" value="CPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="23785" checksum="1FF20A70AB76AE4E" modified="2013-03-06" version="1">MSELNPYELLGVKEDASFEEIQKAKKKLKDKYENNPQQLENIEVAYDAIIMQRLRLRQEGKIKVPEQIRFPEKTVEPKKVTVISNAQKKANISLWFNNLIDQPSGKEILINSSIFLVLIVISIFNNSSETLPLLLTVGVGTSFAVLYRKQRAFWRSVGITFITFIVGICLANVIFSLSLNTGFNLSLSAEQFASLFTFCLLWLVSNFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C7</accession>
    <name>K9Z7C7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen-dependent coproporphyrinogen-III oxidase</fullName>
            <shortName evidence="4">CPO</shortName>
            <shortName evidence="4">Coprogen oxidase</shortName>
            <shortName evidence="4">Coproporphyrinogenase</shortName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemF</name>
        <name evidence="5" type="ordered locus">Cyan10605_2398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220204.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2398"/>
    <dbReference type="EnsemblBacteria" id="AFZ54480">
        <property type="protein sequence ID" value="AFZ54480"/>
        <property type="gene ID" value="Cyan10605_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2398"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2544"/>
    <dbReference type="eggNOG" id="COG0408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_3"/>
    <dbReference type="OMA" id="HDKGTLF"/>
    <dbReference type="OrthoDB" id="1086432at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00333">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for dimerization" evidence="4">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="339" mass="39365" checksum="91F3568C8FD6F108" modified="2013-03-06" version="1">MAKVETNSEKIVPTLPPENAKARVSEFMKTIQEEICAGLEALDGKGKFKEDSWEREEGGGGRSRVMTDGDVFEQGGVNFSEVWGNHLPPSILKQRPEAEGHSFYATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAKHFHSTFKKTCDQHHPEYYPVFKRWCDEYFFLKHRNETRGVGGLFFDYQDGTDPLYRGPHPDKAAATYSNQLPPQPQRSWEEIFAFVQDCGRTFLPAYVPIAEKRRDTEYGERERHFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYNYKPEPNTPEAQLYEVFLKPQNWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F1</accession>
    <name>K9Z7F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220840.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3064"/>
    <dbReference type="EnsemblBacteria" id="AFZ55121">
        <property type="protein sequence ID" value="AFZ55121"/>
        <property type="gene ID" value="Cyan10605_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3064"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3266"/>
    <dbReference type="eggNOG" id="ENOG502Z7M6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103369_0_0_3"/>
    <dbReference type="OMA" id="FWQSHYW"/>
    <dbReference type="OrthoDB" id="1592336at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="25220" checksum="F41D301592448830" modified="2013-03-06" version="1">MTAEQFTLLIHPTLVVISVFPLIGIVCYFAWETRQRRLQIKAGEKSKIPPLVGKNHVEIGKWLSTAVVTVSLIGLARPIIAKNIVKNTLWATNTFQFIFLILIFLFTIITFILLFRARNKLWRGIFATLSGMGVVILGCQDGIFRRTNEWYWSHYYYGVIVTLLMIFSVAIIDDIYRDKSLKWRNIHIILNCLALLLFIGQGYTGARDLFEIGLWSPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F5</accession>
    <name>K9Z7F5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220793.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3014"/>
    <dbReference type="REBASE" id="58390">
        <property type="entry name" value="M.Cap10605ORF3014P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55074">
        <property type="protein sequence ID" value="AFZ55074"/>
        <property type="gene ID" value="Cyan10605_3014"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3014"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3211"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_4_3"/>
    <dbReference type="OMA" id="HPFTPRC"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="423" mass="48423" checksum="53851EF88A615696" modified="2013-03-06" version="1">MKRPIAIDLFSGCGGMSLGLEASGFDVIVAVEFDAIHALIHHLNFPYTHTICQDINHLKTDYLKGILQNKGIDEVDLIAGGPPCQGFSLMGKRQLDDPRNSLVFEYVRVIRDLQPKYFIFENVPGIAVGNHKQFLEELINEFESLGYHIAKPIQILDASLFGAPQKRKRLILMGSRHDMQPVNYPLETGEYNDVENTINDLSNIPAFIGKNESIDANKLDYSGFRRNFAPSPQGIYRLCHDRQRDNFVYNHVGSNHTEKSKQRFQNTHQGEVEKTSRFLKLSPTGLCNTLRAGTARDKGAYTAARPIHYNQPRCITVREAGRLHTFPDWFLFHETIWHGFREIGNAVIPMLAKAIGDEIIKVLEIDINQLEVRKLEKIDLEFMAYNMDKASNYWNVSNDIIPKRKRLEMILTDKLMNLEVFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G7</accession>
    <name>K9Z7G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220053.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54328">
        <property type="protein sequence ID" value="AFZ54328"/>
        <property type="gene ID" value="Cyan10605_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2242"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640695_0_0_3"/>
    <dbReference type="OMA" id="FSTFACK"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="17882" checksum="A2701A6D625DB8AD" modified="2013-03-06" version="1">MIKVIDADLNISAHREAVVELMNTYALDYMGGGEELSDFAKNNLANELAQRKYIHTVLAFVNDNPAGLIIAIEGFSTFACKPLLNIHDVVVASAYRRRGICKLLLQRIEDIALELGCCKLTLEVLEGNQVAQAAYKAFGFDGYQLNPDMGRALFWQKKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R1</accession>
    <name>K9Z7R1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2545"/>
    <dbReference type="EnsemblBacteria" id="AFZ54625">
        <property type="protein sequence ID" value="AFZ54625"/>
        <property type="gene ID" value="Cyan10605_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2545"/>
    <dbReference type="HOGENOM" id="CLU_2842445_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7492" checksum="FD3724AFB7ABB62A" modified="2013-03-06" version="1">MTDDLNSMPEKTPPSTFNNSNTDDVQKKLILPHEKNLENAYREANNEIDNLWDALIADGLDDEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T6</accession>
    <name>K9Z7T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caffeoyl-CoA O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.104</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.104" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220964.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3198"/>
    <dbReference type="EnsemblBacteria" id="AFZ55246">
        <property type="protein sequence ID" value="AFZ55246"/>
        <property type="gene ID" value="Cyan10605_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3198"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3409"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_5_1_3"/>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042409">
        <property type="term" value="F:caffeoyl-CoA O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="25226" checksum="0CC202B391BD0331" modified="2013-03-06" version="1">MTIQTLNLTPPLYEYLLSVSLKEASILKEIREKSSTHPLGKMQIAPEQAQFISLLIKLLGVKKILEIGVFLGYSSTAMALALPEDGQLIACENNPEFAEIARQHWQKASLEDKIILRLDSALDTLEALKEEGYNEEFDLIFIDADKSNYYNYYEKSLDLLRKGGLMIIDNVLWHGRVANPEINDNRTKRMREFNRRLFEDERIELSLLPIGDGLTLVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X7</accession>
    <name>K9Z7X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM receptor with intracellular metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220957.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3190"/>
    <dbReference type="EnsemblBacteria" id="AFZ55239">
        <property type="protein sequence ID" value="AFZ55239"/>
        <property type="gene ID" value="Cyan10605_3190"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3190"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3400"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015767_1_2_3"/>
    <dbReference type="OMA" id="ADFIPEH"/>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="574"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="794" mass="89087" checksum="902F3388C469025F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y0</accession>
    <name>K9Z7Y0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Photosystem I reaction center subunit XI</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">PSI subunit V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">PSI-L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">psaL</name>
        <name evidence="13" type="ordered locus">Cyan10605_3195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 3-162</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PsaL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220962.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="0/L/l=3-162"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z7Y0"/>
    <dbReference type="STRING" id="755178.Cyan10605_3195"/>
    <dbReference type="EnsemblBacteria" id="AFZ55244">
        <property type="protein sequence ID" value="AFZ55244"/>
        <property type="gene ID" value="Cyan10605_3195"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3195"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3406"/>
    <dbReference type="eggNOG" id="ENOG502ZMJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092204_1_0_3"/>
    <dbReference type="OMA" id="GPFTICG"/>
    <dbReference type="OrthoDB" id="1791383at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00447">
        <property type="entry name" value="PSI_PsaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003757">
        <property type="entry name" value="PSI_PsaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036592">
        <property type="entry name" value="PSI_PsaL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022980">
        <property type="entry name" value="PSI_suXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34803">
        <property type="entry name" value="PTHR34803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02605">
        <property type="entry name" value="PsaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81568">
        <property type="entry name" value="SSF81568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PsaL" evidence="12">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="163" mass="17074" checksum="C79668DCE36B79F5" modified="2013-03-06" version="1">MSIDVVNHGGDPQVGNLSTPINGSAFTKAFINALPAYRKGLSPNRRGLEVGMAHGYLLYGPFAVLGPLRLTEYGPTAGLLATIGLVSILTICLSIYGAVGVSKPTETLTTPEVPMDLATKEGWSEFAGGFLLGGCGGAFFAFFLCQTPHLQPLIEVASNIWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y1</accession>
    <name>K9Z7Y1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">Cyan10605_2421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2421"/>
    <dbReference type="EnsemblBacteria" id="AFZ54503">
        <property type="protein sequence ID" value="AFZ54503"/>
        <property type="gene ID" value="Cyan10605_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2421"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2565"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_3_3"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="26273" checksum="E39F2E7E11D3F860" modified="2013-03-06" version="1">MKLSYYVNVVKLIMISEQENRGYFIVFEGIDGSGSSTQADLLHQYFLSQNQESVLSPEPSNGKIGKLLREFLANPPSFLSDDLFEQQMAYLFTADRHFHLYNNVDGVKKLVEQNINVITTRYYFSSLAYNGKTESDFHFVANLNQNFPPPDLLIYLDIPVDIALNRIGNRPFKEVYENKQKLTLVRQNFEKIIDEYKYPYLKIDACQKQTEIHQQIIDSLASTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z804</accession>
    <name>K9Z804_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220413.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2615"/>
    <dbReference type="EnsemblBacteria" id="AFZ54690">
        <property type="protein sequence ID" value="AFZ54690"/>
        <property type="gene ID" value="Cyan10605_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2615"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2778"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451082_0_0_3"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="326"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="605" mass="71074" checksum="AB4124635CDFEAE6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z812</accession>
    <name>K9Z812_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220256.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54533">
        <property type="protein sequence ID" value="AFZ54533"/>
        <property type="gene ID" value="Cyan10605_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2452"/>
    <dbReference type="HOGENOM" id="CLU_1882285_0_0_3"/>
    <dbReference type="OrthoDB" id="2175101at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15677" checksum="FDB422D5C6709361" modified="2013-03-06" version="1" precursor="true">MKNFSKICCVFFILLSSNFSDKKASAQIQSTPSENLLRNRYYFKLGLQQVDNICQSFTSSSLKNDCNKILSETTFFDPDAVFFCEQKFNISSRTITCFKYIQDKFYVESELKDCGNSMNYSNIFKCLSKKGRPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z828</accession>
    <name>K9Z828_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3253"/>
    <dbReference type="EnsemblBacteria" id="AFZ55299">
        <property type="protein sequence ID" value="AFZ55299"/>
        <property type="gene ID" value="Cyan10605_3253"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3253"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3468"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_2_3"/>
    <dbReference type="OMA" id="CDVPLFS"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="18822" checksum="B4AD555DA7500AD9" modified="2013-03-06" version="1" precursor="true">MKRRTLLSAGLGAFCIAIPSIIAFILGMEESKSEENKSIKKLNLTQAQWKKKLTPAQYHILREEGTEKPFSSALNNEKRKGIYTCAGCDLPLFKSEMKYDSGTGWPSFYDTITQAVETKADFKLLIPRTEYHCARCGGHQGHVFNDGPKPTGKRYCNNGLALKFIPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z837</accession>
    <name>K9Z837_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221074.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3311"/>
    <dbReference type="EnsemblBacteria" id="AFZ55356">
        <property type="protein sequence ID" value="AFZ55356"/>
        <property type="gene ID" value="Cyan10605_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3311"/>
    <dbReference type="eggNOG" id="ENOG502ZJEA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188367_0_0_3"/>
    <dbReference type="OMA" id="MLNICLK"/>
    <dbReference type="OrthoDB" id="2057778at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="8936" checksum="CF26FBF9FB08C6F9" modified="2013-03-06" version="1">MARIKFIKSRGGLTTTERILQIIQENPKGLTLKSLKREINRPVSMLNICLKTLIQTKQIRVTVELNEDQIQKIYSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C5</accession>
    <name>K9Z8C5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220552.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2762"/>
    <dbReference type="EnsemblBacteria" id="AFZ54830">
        <property type="protein sequence ID" value="AFZ54830"/>
        <property type="gene ID" value="Cyan10605_2762"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2762"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129738_0_0_3"/>
    <dbReference type="OMA" id="TLEIASH"/>
    <dbReference type="OrthoDB" id="1775530at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="160" mass="17728" checksum="AFBA38D1DA23A91F" modified="2013-03-06" version="1">MNTANLPNQPSSSTEKVKLLVFSIGNLNTALHIDAVEKVVNYNQIFGSGLNHFGLVNLGDKEITVVDLHKKLFNSPQALSTEGKKYLLLVKNSGGETFGIVISQTPELYDVPLNVIRILPPSYRRADTLKIASHVAVFRENEEEKTIFLLDPDELINPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E4</accession>
    <name>K9Z8E4_CYAAP</name>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2563"/>
    <dbReference type="EnsemblBacteria" id="AFZ54643">
        <property type="protein sequence ID" value="AFZ54643"/>
        <property type="gene ID" value="Cyan10605_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2563"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2720"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_3"/>
    <dbReference type="OMA" id="LEPFIIM"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="32"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="387"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="432"/>
            <end position="452"/>
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            <end position="925"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="946"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="979"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112349" checksum="345D547052CC1BC4" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">PCC 10605</strain>
        </source>
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        <property type="gene ID" value="Cyan10605_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2580"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:potassium ion transport"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="129"/>
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    <feature type="domain" description="RCK N-terminal" evidence="2">
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            <end position="494"/>
        </location>
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            <end position="590"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="665" mass="75144" checksum="2CE0260B55267B46" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H7</accession>
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        </recommendedName>
    </protein>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
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    </evidence>
    <sequence length="304" mass="34677" checksum="4CD757F21DA4A5CF" modified="2013-03-06" version="1">MQTNLELNLLEKAVTPTFARHETFHPRWGWLKKGFDMASIDGKIFNGEDAPVKLGVGKNMVRSLRYWCYTFKIIDEDNTPSAFGNNLLGVNGWDRYLENPASLWLLHWSLLKPTCNAGAWYYVFNLFNQNEFTKEDLLKGLMDYLQGLNKTVAESSLVKDINCILRMYVESDNNNSNFVEDSIDCPFTELGLIYQPKNSNYYRFRFGSKANLPSAIIVATCLEYASWVSQNQSTITISRLLYDKGSPGTVFKLSEEAIYSAIEAVCRQESSLFLADTAGLVQLSFEENPLDLAYQILNNYYGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S4</accession>
    <name>K9Z8S4_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Peptidase domain protein</fullName>
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    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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    <dbReference type="STRING" id="755178.Cyan10605_3065"/>
    <dbReference type="EnsemblBacteria" id="AFZ55122">
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        <property type="gene ID" value="Cyan10605_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3065"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3267"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122370_0_0_3"/>
    <dbReference type="OMA" id="GFARDYT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="19438" checksum="3D8005AE506AF61E" modified="2013-03-06" version="1">MTFRNINFVIFFYFLVAIVNILLWGKNAITLAAPLVNQQSNFLKGEEETLQTAQSKIYNPIPIPENQPINDQLTADDIPTGEGGFARDYYIFLQKGDQIAIDLISDEFDSIVVLMSEDGTTIAENDDAPDSSTNSLLFTRIAETGKYIIRVRAFGQTGNGNFQLKVTRLQPIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z907</accession>
    <name>K9Z907_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220580.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2791"/>
    <dbReference type="EnsemblBacteria" id="AFZ54858">
        <property type="protein sequence ID" value="AFZ54858"/>
        <property type="gene ID" value="Cyan10605_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2791"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2966"/>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052147_0_0_3"/>
    <dbReference type="OMA" id="YPERRHC"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="39017" checksum="CF9D486AB37B455A" modified="2013-03-06" version="1">MKVTRENIIWESHQKHVPTIDEEGGKLWGCFRSCFLQSAAPYTEGIAYKILKNDLGIDLREAAGHTSCGAIGYHGDVTNIETQMVVAARNFAVAHDELGVDNLFSFCVTSFANYTEMIHLWEEEPELREYTAKTLKETTGREFWIPYVSGGRPSVVHASDVFYANRHKLAEKAKYSLKGIKAVDHIGCHYGKIFPGEAMGGVEFPQVLVGLLEAFGAEIVDYPERRHCCGMGFRQCAFPENRDYTASSTYKKLASLKEAHPDCNLILTNCPGCTVFLDAEQGTIKEVLEEEFNVSILDYAQLTGLMLGYDPFKDCGMNAKVVPVEPLLDKIGIPYDKSKTFEQRRRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z915</accession>
    <name>K9Z915_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photosystem II reaction center protein I</fullName>
            <shortName evidence="8">PSII-I</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PSII 4.4 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">psbI</name>
        <name evidence="9" type="ordered locus">Cyan10605_3038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cellular thylakoid membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PsbI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220814.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3038"/>
    <dbReference type="EnsemblBacteria" id="AFZ55095">
        <property type="protein sequence ID" value="AFZ55095"/>
        <property type="gene ID" value="Cyan10605_3038"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3038"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3234"/>
    <dbReference type="HOGENOM" id="CLU_212150_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01316">
        <property type="entry name" value="PSII_PsbI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003686">
        <property type="entry name" value="PSII_PsbI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037271">
        <property type="entry name" value="PSII_PsbI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35772">
        <property type="entry name" value="PTHR35772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02532">
        <property type="entry name" value="PsbI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161041">
        <property type="entry name" value="SSF161041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="2 8" id="KW-0674">Reaction center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="38" mass="4205" checksum="8FADA12C48779171" modified="2013-03-06" version="1" precursor="true">MLTLKIVVNIVVASFILLFIFGFLSGDPARNPGRKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z932</accession>
    <name>K9Z932_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase</fullName>
            <ecNumber evidence="2">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220834.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3058"/>
    <dbReference type="EnsemblBacteria" id="AFZ55115">
        <property type="protein sequence ID" value="AFZ55115"/>
        <property type="gene ID" value="Cyan10605_3058"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3058"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3259"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_3"/>
    <dbReference type="OMA" id="ISDHHIR"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="44426" checksum="9837ADF71B59FE62" modified="2013-03-06" version="1">MVKVNKIVILGGGFGGLYTAIKLAQFPWQESNPEIVLIDKNDRFLFSPLLYELITDEMQSWEVAPSYYELLSNTSIRFLQDTVTEIDDTARQISLKNNGDLSYDYLVMALGGKTPVNQVSGASDFAIPFRTLEDAYRVKEKLRVLENSDLEAIRVVVVGGGYSGVELALKVADRLGKRGKIRIVDRGSEILSDSPEFNRKTAEKALRDRTIWTDLETEVTNITEKDISLSYKNQIDTIPVDLVLWTVGTKPVMLEKKFPFATNAQGKIEINSYLQVKDNSVVWALGDLVECYDQQGKKLPATAQVAFQQADYCAWNIWATIENKPLLAFKYQPLGEMLALGKDSATISGLGLSLGGGLGYLARRLIYLYRLPTFEHQMAVAMNWITSPLTQLIGSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z960</accession>
    <name>K9Z960_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220864.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3089"/>
    <dbReference type="EnsemblBacteria" id="AFZ55145">
        <property type="protein sequence ID" value="AFZ55145"/>
        <property type="gene ID" value="Cyan10605_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3089"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="OMA" id="DDSAMWS"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="12051" checksum="E7542736EDE6EAE2" modified="2013-03-06" version="1">MSLINIDKIPQDKLEKICQKWLVKELALFGSILTNKFNENSDIDVLVTFDDSAMWSLFDIVRLKNELKNLFKQEVDLVEKSALSNPFIRYEIINNPQIIYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z961</accession>
    <name>K9Z961_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220980.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3215"/>
    <dbReference type="EnsemblBacteria" id="AFZ55262">
        <property type="protein sequence ID" value="AFZ55262"/>
        <property type="gene ID" value="Cyan10605_3215"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3215"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3427"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="29043" checksum="708B7E8F4316A9BB" modified="2013-03-06" version="1">MFLQIKNLHKSFDTENGKLSVLKDINMTIKEGEFICAVGASGSGKSTLLRQIAGLDKPCFGEIKIDGKLITAPGPDRGMVFQHYTLYPWLNVQENTEFGLKLQGVPKKERKEKASYYLSVVGLSNFAKSLPKQLSGGMKQRVAIARALTSEPKVLLMDEPFGALDIHTKESMHEFILDLWQRTNLTIFMITHDVEEAVFLSNRIYALGSRPGTVRKEITINLPERTSHIKRHSIFHDYRDELMELLRLHGKEALMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J1</accession>
    <name>K9Z9J1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CO2 hydration protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2993"/>
    <dbReference type="EnsemblBacteria" id="AFZ55053">
        <property type="protein sequence ID" value="AFZ55053"/>
        <property type="gene ID" value="Cyan10605_2993"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2993"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3189"/>
    <dbReference type="eggNOG" id="COG2441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707219_0_0_3"/>
    <dbReference type="OMA" id="PMDFYWR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010220">
        <property type="entry name" value="CO2_hydration"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10216">
        <property type="entry name" value="ChpXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01964">
        <property type="entry name" value="chpXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="51950" checksum="FC119DA6CC94F6E2" modified="2013-03-06" version="1">MELGYSNDLDVINYQLSIMKTATKIPPSTHEFAEVIHRLEAGGSMLPDTPENLMQIIGIYKAYAIPMDFYWRDLLYIAERVFLNPLPFFKYFISQEYLDLPNHYAGDTADLRIWRGQASAHPELLAFMEKGETSKMPKLFHHLMHDRVNMEFAEACMRAMLWHGRDMGMGKFDAYLDSDEYKANADKAIKAYFKGNPLMLGLYKLFPEMFLEQVRQLSYYANLGLFWEIMTAVFLEMSDIYDEGGFKGVPDAMDFLVNGIFAIAGRPIYHNVYIKGECYEIIPKSKGFTWLYEAALPYVEAVFYRTAPFRGTKSYNAQAHQVPREQKDFHYGILYADVFPVGSAGIPPTLLMDDMLHFLPDYLVEYYQKHCRGEDDMLIQLGVTFQRSMYNVTSAVIQALRTALLYPLDDDNPKHLMKNRQFFEMQMDRFKRPEARLRDIQSQDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9M1</accession>
    <name>K9Z9M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220993.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3229"/>
    <dbReference type="EnsemblBacteria" id="AFZ55275">
        <property type="protein sequence ID" value="AFZ55275"/>
        <property type="gene ID" value="Cyan10605_3229"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3229"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3443"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141446_2_0_3"/>
    <dbReference type="OMA" id="MIIMPAN"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12293" checksum="FE4C78DE99D17015" modified="2013-03-06" version="1">MSILELKSSFVNLSEHIEYPSEGILSKVLLKDKNCQYTLFCLAKNTEISEHTSSRNATVHVIEGEGVLILEGEKIILTKGVFVVMPSNAPHALQATENLCFLLTLSATDNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N8</accession>
    <name>K9Z9N8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221013.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3249"/>
    <dbReference type="EnsemblBacteria" id="AFZ55295">
        <property type="protein sequence ID" value="AFZ55295"/>
        <property type="gene ID" value="Cyan10605_3249"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3249"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3463"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_8_0_3"/>
    <dbReference type="OMA" id="IWDLGFQ"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4131" evidence="8">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="239"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="701" mass="80252" checksum="D30D5CDB646CF3ED" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAH9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ55398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3356"/>
    <dbReference type="EnsemblBacteria" id="AFZ55398">
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        <property type="gene ID" value="Cyan10605_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3356"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3574"/>
    <dbReference type="eggNOG" id="ENOG502ZQYK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176958_1_0_3"/>
    <dbReference type="OMA" id="MLGNNLM"/>
    <dbReference type="OrthoDB" id="2086365at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="6476" checksum="C22A35E55E509CB1" modified="2013-03-06" version="1" precursor="true">MADQKSSFQLPCVALSLLTPPMVLGQMLGNNLMSLLVDMGKASEEIFRGERLPILKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAR7</accession>
    <name>K9ZAR7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3448"/>
    <dbReference type="EnsemblBacteria" id="AFZ55488">
        <property type="protein sequence ID" value="AFZ55488"/>
        <property type="gene ID" value="Cyan10605_3448"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3448"/>
    <dbReference type="eggNOG" id="COG1403">
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    </dbReference>
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    <dbReference type="OMA" id="CSACHLY"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="9741" checksum="62BA22AB10E204C2" modified="2013-03-06" version="1">MSRYSKDWNKIACAIKQKADWKCSQCGADFKNKSSRGSCLQVHHWNRIPEDNRPENLVALCNICHLKYHRGGKSNILIGQLSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZB24</accession>
    <name>K9ZB24_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221293.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3545"/>
    <dbReference type="EnsemblBacteria" id="AFZ55578">
        <property type="protein sequence ID" value="AFZ55578"/>
        <property type="gene ID" value="Cyan10605_3545"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3545"/>
    <dbReference type="HOGENOM" id="CLU_2616076_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="9085" checksum="AB5BB05C379979B1" modified="2013-03-06" version="1">MINLNIYKSHNNTWYLDARGCNNVDWILLHPDLKPYVTLDEDGGFITLEGMETLGKIALCDKFNHHIYIPRRLAEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZC7</accession>
    <name>K9YZC7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218028.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0139"/>
    <dbReference type="EnsemblBacteria" id="AFZ52296">
        <property type="protein sequence ID" value="AFZ52296"/>
        <property type="gene ID" value="Cyan10605_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0139"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.143"/>
    <dbReference type="eggNOG" id="ENOG502Z7TH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823696_0_0_3"/>
    <dbReference type="OMA" id="QTEIWRG"/>
    <dbReference type="OrthoDB" id="900550at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="38616" checksum="EDDA854FDC26864F" modified="2013-03-06" version="1">MVETVPSPVEIAEALTIPADLEFNLPDPEDDQIAEEDFLQKVDDVWKVCDRFDLQTDIWRGRILRAVRDREKVGGEGRGTGFLNWLKNREITKSQAYALIQLANSADTLLEEGNLEPTAINNFSKRAFVETAKAEPEIQKLVSEAAQKGDRITRREVKQLTDEYTAMNSDLIPESVKEKAVDGSLPPRHLAPLVKELEKLPEEQISEIQKEIESNPDVDTVKQMTSTAKSLSKYLDSAAQVETLRDSAVDIESALQEALRLDCLSLTADLVKQATNLEQNVGKLYTLWKKLGSIADRLYVETGSSTPSLRSLLSCLEKLTSEVIELRLDDEGEKMIRLRIMTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZE0</accession>
    <name>K9YZE0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0115"/>
    <dbReference type="EnsemblBacteria" id="AFZ52274">
        <property type="protein sequence ID" value="AFZ52274"/>
        <property type="gene ID" value="Cyan10605_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0115"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_1_3"/>
    <dbReference type="OMA" id="WIMSNEN"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="41"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="588" mass="67496" checksum="C2CC0DC2791CB3C6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZL4</accession>
    <name>K9YZL4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="8">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG</name>
        <name evidence="13" type="ordered locus">Cyan10605_0239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218123.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0239"/>
    <dbReference type="EnsemblBacteria" id="AFZ52391">
        <property type="protein sequence ID" value="AFZ52391"/>
        <property type="gene ID" value="Cyan10605_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0239"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.248"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_3"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="157"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="534" mass="61828" checksum="505E6C39B71F4C28" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZW2</accession>
    <name>K9YZW2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">LL-diaminopimelate aminotransferase</fullName>
            <shortName evidence="7">DAP-AT</shortName>
            <shortName evidence="7">DAP-aminotransferase</shortName>
            <shortName evidence="7">LL-DAP-aminotransferase</shortName>
            <ecNumber evidence="4 7">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dapL</name>
        <name evidence="9" type="ordered locus">Cyan10605_0344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218222.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0344"/>
    <dbReference type="EnsemblBacteria" id="AFZ52491">
        <property type="protein sequence ID" value="AFZ52491"/>
        <property type="gene ID" value="Cyan10605_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0344"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.360"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051433_0_0_3"/>
    <dbReference type="OMA" id="DFQARGC"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033362">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="408" mass="45071" checksum="0BDC9453954A3037" modified="2013-03-06" version="1">MARINDNYLKLKAGYLFPEIARRVNAFAQANPDAKIIKLGIGDVTEPLPQACRNAMVKAVEDMGDRANFKGYGPEQGYLWLREAIATNDFQARGCDISPDEIFISDGSKCDTGNILDIFGKDNKIAVTDPVYPVYVDTNVMAGHTGEANEKGEYEGLVYLPISAENDFTAELPNEAVDLIYLCFPNNPTGATATKEYLQKWVDYAKANDSIILFDAAYEAFITDPTLPHSIYEIEGAKECAIEFRSFSKNAGFTGTRCALTVVPKTLKGKANDGSEVELWKLWNRRQSTKFNGVSYIVQRGAEAVYSPEGKAQIKELVNFYLENAKIIREELTKAGLTVYGGVNAPYVWVKTPDGLSSWDFFDKLLHNDNVVGTPGSGFGAAGEGYFRLSAFNSRENVIEAMRRINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZW8</accession>
    <name>K9YZW8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0349"/>
    <dbReference type="EnsemblBacteria" id="AFZ52496">
        <property type="protein sequence ID" value="AFZ52496"/>
        <property type="gene ID" value="Cyan10605_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0349"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.365"/>
    <dbReference type="eggNOG" id="ENOG502Z8M9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080710_0_0_3"/>
    <dbReference type="OMA" id="HDPSFRT"/>
    <dbReference type="OrthoDB" id="1663862at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="31259" checksum="6197BC283CCEA00B" modified="2013-03-06" version="1">MNILTVLCEGIKDSSEVREKEREEREKGYFKYPNYDLVKYIQVFVNIRFLSLPVFVLTLVFYSLSISQVCGETVGDSSNLDVDPSLIENSPVIQKWIKEIPDVSDEIRNQPSFPTLFRIGYSQFPSNHHSGGVYFGIEDLFVGDTPLTFSADYSSDLSNNSQGQRLSVGSTIQYYLLPLGSYINIAPVVGYRYIETNGYHSDGVNVGVKVKLAFSPQGAADISLIQSFIAPTSNDEVGVTEIKAGYAINKHLRLSSGISWQNSIKQEDSQLNIGLEWILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z030</accession>
    <name>K9Z030_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-amino-acid oxidase</fullName>
            <ecNumber evidence="2">1.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.3.2" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ52524">
        <property type="protein sequence ID" value="AFZ52524"/>
        <property type="gene ID" value="Cyan10605_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0379"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.399"/>
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        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01593">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="531" mass="59269" checksum="7B4CEFE45DB33CE7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z032</accession>
    <name>K9Z032_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Serpentine Receptor, class X family member (Srx-82)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="755178.Cyan10605_0422"/>
    <dbReference type="EnsemblBacteria" id="AFZ52566">
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        <property type="gene ID" value="Cyan10605_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0422"/>
    <dbReference type="HOGENOM" id="CLU_3078974_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="52" mass="6048" checksum="70F95C965A4180BE" modified="2013-03-06" version="1">MNIFAKIIDIKYQKIFTLELKLINDSEFDINLIPSNCFLSYSNNNLSFGICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z059</accession>
    <name>K9Z059_CYAAP</name>
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        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">Cyan10605_0410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Chroococcales</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ52554.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0410"/>
    <dbReference type="EnsemblBacteria" id="AFZ52554">
        <property type="protein sequence ID" value="AFZ52554"/>
        <property type="gene ID" value="Cyan10605_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0410"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.433"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_3"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="691" mass="76044" checksum="188F93E407BACADA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I1</accession>
    <name>K9Z0I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217954.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0061"/>
    <dbReference type="EnsemblBacteria" id="AFZ52222">
        <property type="protein sequence ID" value="AFZ52222"/>
        <property type="gene ID" value="Cyan10605_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0061"/>
    <dbReference type="eggNOG" id="ENOG50330SB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2857959_0_0_3"/>
    <dbReference type="OMA" id="YECQMGF"/>
    <dbReference type="OrthoDB" id="2035382at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7322" checksum="6DE2B00A691A960C" modified="2013-03-06" version="1">MLVILQKEQILSTDSVCQNCLWANQQGSPRWQGGKLSCGHCLGTSEPRQPQLYECQMGFRLVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M7</accession>
    <name>K9Z0M7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menC</name>
        <name evidence="5" type="ordered locus">Cyan10605_0602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218472.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0602"/>
    <dbReference type="EnsemblBacteria" id="AFZ52741">
        <property type="protein sequence ID" value="AFZ52741"/>
        <property type="gene ID" value="Cyan10605_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0602"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.635"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_4_3"/>
    <dbReference type="OMA" id="DIVDHRH"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="UniPathway" id="UPA00995"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="41277" checksum="28EE30CD269B4B60" modified="2013-03-06" version="1">MKIEEIQLYQLSIPFIRPFQFSNGELCNHDCLIVAVKSEGIIGWGECPVFPIPYYTYETIATASHILKDFLIPQLLGKSIDSLVALNKVFSRVRGHNMAKSCLDAAICDLLARVNSVSLSQFLGGEKKRIQVGVSVSMQDNLIYLLQRIEDYIQQGYQRIKLKIAPNYAIQPLKTIREKYPYLTLMADANSSFSLNDIDLLKALDEFDLLMIEQPLAHDDLLDHAYLQTLIKTPICLDESINNLHDTRVAIALQAGKIINLKPSRVGGISNALQIHDLCQKAGIKLWCGGMLESGIGRATNLHLASLSNFTLPADISATNRYFYEDIIHQVFSLNSSDSTIDVPQGFGIGVDINQESFNKFVQTCDTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N8</accession>
    <name>K9Z0N8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ordered locus">Cyan10605_0573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218445.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0573"/>
    <dbReference type="EnsemblBacteria" id="AFZ52714">
        <property type="protein sequence ID" value="AFZ52714"/>
        <property type="gene ID" value="Cyan10605_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0573"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.604"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_3"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="33402" checksum="DDC7ED4F76EC5E08" modified="2013-03-06" version="1">MTTENNAQFYHQSVLPQEIIDSLNIINNGHYLDATLGAGGHTELILKQGENVKITAIDQDINAINFAQEKLKNYQDKISFFQGNFADFKPFNTLFDGIIADLGVSSPQLDNPERGFSFRLEGDLDMRMNQSQSLSAKDIVNHWQEKQLADLIFLYGEERLSRRIARMIIQKRPFYTTTALADAIASCVPSKYRYGKIHPATRTFQALRIKVNEELNSLEKFLQIAPTWLKPEARIAIISFHSLEDRIVKNQFRSHPLLKIVTKKPIIPSIEEQKVNPRARSAKLRIAYREAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z121</accession>
    <name>K9Z121_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ordered locus">Cyan10605_0768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218632.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0768"/>
    <dbReference type="EnsemblBacteria" id="AFZ52901">
        <property type="protein sequence ID" value="AFZ52901"/>
        <property type="gene ID" value="Cyan10605_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0768"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_8_1_3"/>
    <dbReference type="OMA" id="NILNWAV"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="18989" checksum="C7429430BC0BE35D" modified="2013-03-06" version="1">MINLFYLAVEEAGGGFGISSDILGSNLINLVIVIGLLVVYGGKFVGNILTERRNRITEEIKEAEERAKTAAKALAEAKENLSQAQAKAKQIKATAQETAKTTREQILAQGQKEIERMKATAVQELDSERAKVVTELKRTIAVLALQKAEQDLQDRLNDDIQGKLISRAVEQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z161</accession>
    <name>K9Z161_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 type 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218032.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0143"/>
    <dbReference type="EnsemblBacteria" id="AFZ52300">
        <property type="protein sequence ID" value="AFZ52300"/>
        <property type="gene ID" value="Cyan10605_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0143"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137425_0_0_3"/>
    <dbReference type="OMA" id="GWVKAGN"/>
    <dbReference type="OrthoDB" id="2001565at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17092" checksum="7A5F21DFC9765FC3" modified="2013-03-06" version="1" precursor="true">MSISSLFQFLIGFFLGIILFTAGIAGGAYFFLTQVSGNPPKPSFPEENSAVEEIPQPDESSNQAETATEETAKETQETTTNEETEDLPEGAYRGKVIWSTGLSLRAEPGIDSERIGGVGYNWEIVILGTSDDGGWQKIRIPSSGQEGWVKAGNIEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F5</accession>
    <name>K9Z1F5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218730.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0869"/>
    <dbReference type="EnsemblBacteria" id="AFZ52999">
        <property type="protein sequence ID" value="AFZ52999"/>
        <property type="gene ID" value="Cyan10605_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0869"/>
    <dbReference type="eggNOG" id="ENOG5034409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1934545_0_0_3"/>
    <dbReference type="OrthoDB" id="2186727at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14640" checksum="79D25FC13016BA69" modified="2013-03-06" version="1">MIEGYTDFPDEDELMQEEGEVVYSLCWDSGAPGAGADCELIYSWKGQYVVCLSYDVNRPAYPSLIEAIMGAELNFVNDATTEIESTELSSEQIIPLLAIDINSDLHELTINREDWEVDKQGNFTRIVYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M3</accession>
    <name>K9Z1M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218837.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0976"/>
    <dbReference type="EnsemblBacteria" id="AFZ53106">
        <property type="protein sequence ID" value="AFZ53106"/>
        <property type="gene ID" value="Cyan10605_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0976"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070320_0_1_3"/>
    <dbReference type="OMA" id="TGIGHMD"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="29220" checksum="D774E581D5554E94" modified="2013-03-06" version="1">MVVATKKILQITDTHLDEKSTTHGHNVYDKLAMVFEQTIEKKDFDLIIFSGDISDKGSLNSYEWLAKKTENYNSKIIWMAGNHDSVDNMKQVFNLPFLVDIEENKLNYQLNLSGINILCLDTNDKLLSDNQIDWLIESTDDNTIIFIHHPPITCASPFMDDNHSLANWKIIKEKLSTISNKTFRFFCGHYHQESYISYQNIHLFLTPSTMFQIDRHKPHFQIANTLSGYRIIEIFEDKSFKTYCDYIFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q9</accession>
    <name>K9Z1Q9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">Cyan10605_0370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0370"/>
    <dbReference type="EnsemblBacteria" id="AFZ52515">
        <property type="protein sequence ID" value="AFZ52515"/>
        <property type="gene ID" value="Cyan10605_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0370"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.390"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_2_2_3"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="665"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="843"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1197" mass="135642" checksum="EE9D07238D33E867" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z272</accession>
    <name>K9Z272_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ordered locus">Cyan10605_1112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218965.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1112"/>
    <dbReference type="EnsemblBacteria" id="AFZ53234">
        <property type="protein sequence ID" value="AFZ53234"/>
        <property type="gene ID" value="Cyan10605_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1112"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1176"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_3"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="541" mass="57881" checksum="23BE22B1EDF99E71" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z296</accession>
    <name>K9Z296_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219055.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1207"/>
    <dbReference type="EnsemblBacteria" id="AFZ53326">
        <property type="protein sequence ID" value="AFZ53326"/>
        <property type="gene ID" value="Cyan10605_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1207"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1274"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001721_3_1_3"/>
    <dbReference type="OMA" id="CIEAHIG"/>
    <dbReference type="OrthoDB" id="370520at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="2">
        <location>
            <begin position="398"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="2">
        <location>
            <begin position="677"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="787" mass="92842" checksum="252B0919FE4384F4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B2</accession>
    <name>K9Z2B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219013.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1162"/>
    <dbReference type="EnsemblBacteria" id="AFZ53284">
        <property type="protein sequence ID" value="AFZ53284"/>
        <property type="gene ID" value="Cyan10605_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1162"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1229"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101283_1_0_3"/>
    <dbReference type="OMA" id="CHMTLTA"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="PTHR37302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="21453" checksum="D524E3B09A30356A" modified="2013-03-06" version="1">MNQKQNYLLMAEYNSWMNEKIYSICKQIPHEKLHQNLGAFFLSIIGTLNHILVADIIWLKRFSDHPKNYSSLDYIRSIKKPHSLNQIIYDRIEDLTLEREKIDQIIKDFILEITEEDLENSFSFNNMKGEHFNKKFSYIILHFFNHQTHHRGQVSTLLSQLNLELGITDLLVLIPSFDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C9</accession>
    <name>K9Z2C9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ordered locus">Cyan10605_0399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218274.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0399"/>
    <dbReference type="EnsemblBacteria" id="AFZ52543">
        <property type="protein sequence ID" value="AFZ52543"/>
        <property type="gene ID" value="Cyan10605_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0399"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.422"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_3"/>
    <dbReference type="OMA" id="GRCPNRG"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="33015" checksum="4CA37B0AD3C6C8AA" modified="2013-03-06" version="1">MTVTSSPTSDLINLPSWLRAPIGKASEISRVQKIVKQRKIHTICEEGRCPNRGECYSQGTATFLLMGDVCTRNCGFCQVEKGKAPMILDENEPQKVAEAVNLLGLKYVVLTSVARDDLADGGAFWFVKVMDAIRKMNPDTLIEVLTPDFGTGKNALQQQWDSVKTIVEANPACYNHNLETVARLQNPVRKGGKYHRSLRVLEIVKEINPDIPTKSGLMLGLGETLAEIIATLEDLRKIKCDRITLGQYLRPSLAHLPVQKYWTPDEFEELGKIASSLGFSHVRSAPLVRSSYHAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N1</accession>
    <name>K9Z2N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-lysine 6-monooxygenase (NADPH)</fullName>
            <ecNumber evidence="4">1.14.13.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219138.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1294"/>
    <dbReference type="EnsemblBacteria" id="AFZ53409">
        <property type="protein sequence ID" value="AFZ53409"/>
        <property type="gene ID" value="Cyan10605_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1294"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1367"/>
    <dbReference type="eggNOG" id="COG3486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_0_0_3"/>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="433" mass="50403" checksum="6C2E8607F34C9350" modified="2013-03-06" version="1" precursor="true">MTEKIYDLLGVGIGPFNLSLAALIEPISHLETIFLEQKTEFQWHEGLLMEGTTIQVPFLADLVTMADPCSRFTFLNYLREHSRLYNFYFLEEFKIYRREYNHYCQWVSQQLKSCRFSEKVESITWHEEGYFIVQSKNVLTSETSSYKAKNLVLGVGTTPAMPPCFKNFQSQENIFHSAEFLHKQNQYQTAKSVTVIGSGQSAAEVFYQLLQDQEKYHYHLEWHTRSSGFFPMEYSKLGLEHFSPDYIKYFYHLPQEKRDQIRSRQNLLYKGISFSLIADIYNLLYERSIGQKALNVRLRPLLEVKEVEQTEMGYRLSYRHCQEDAYVSHDTDCIILATGYQHSIPPFMDGLNSLIQWDSQHRYDVNFDYRLQLTQDIPNSIFVQNGELHTHGIGTPDLGLGAHRSSVIINTLLGEEIYPVSSQNVFQEFGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P7</accession>
    <name>K9Z2P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1309"/>
    <dbReference type="EnsemblBacteria" id="AFZ53424">
        <property type="protein sequence ID" value="AFZ53424"/>
        <property type="gene ID" value="Cyan10605_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1309"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1382"/>
    <dbReference type="eggNOG" id="COG5381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100987_0_0_3"/>
    <dbReference type="OMA" id="DAKMAWA"/>
    <dbReference type="OrthoDB" id="1908096at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046239">
        <property type="entry name" value="DUF6272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19788">
        <property type="entry name" value="DUF6272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="23221" checksum="47D80A58E1F23057" modified="2013-03-06" version="1">MGHRMQTFGNFIDKFPPEQDSLELTFTPTSVPLKKRWRNNRLSAYFIADYFTTFLPLDDSQIEEQKRIHESKSAVSYVANELLENAMKYNYEEAHSQIKFGVHFLQNSSLIAVVFASNSVTVNNQKKLENFIHKLQNNDPENLYIEHLEKNALEEDQCSGLGILTIINDYNAEIGWKFEKMSSQNHDSFFLVTTMVQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P8</accession>
    <name>K9Z2P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218733.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0872"/>
    <dbReference type="EnsemblBacteria" id="AFZ53002">
        <property type="protein sequence ID" value="AFZ53002"/>
        <property type="gene ID" value="Cyan10605_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0872"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.917"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_3"/>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35444" checksum="3C978A4377C35CBC" modified="2013-03-06" version="1" precursor="true">MEQLFILVFLVGSALFSSVKIVNEKNEYLVERLGSYNKKLSPGLNFVIPFLDNVVYKDTIRDKILDVPPQSCITKDNVAITVDAVVYWRIVDMVKAYYKIENLQSGMENLVLTQIRAEIGKLELDETFVARSEINSVLLRELDIATDPWGVKVLRVELKDITPSPAVQQSMEQQMAAERKKRASILNSEGERDSAINSAKGSAEAKILEAESMKKASIMEAEARKQQQILQAQATAEALQIIVDQVKNDPQAQTALQFLLTQQYLEMGKVIGSSDSSKVMFIDPNNILSTLNGISSIIDNDNQLTKFSAPIIKENKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S3</accession>
    <name>K9Z2S3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Ferredoxin-thioredoxin reductase, catalytic chain</fullName>
            <shortName evidence="15">FTR-C</shortName>
            <ecNumber evidence="4 15">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">Cyan10605_0742</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 17">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13 15">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="4 15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218606.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0742"/>
    <dbReference type="EnsemblBacteria" id="AFZ52875">
        <property type="protein sequence ID" value="AFZ52875"/>
        <property type="gene ID" value="Cyan10605_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0742"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.779"/>
    <dbReference type="eggNOG" id="COG4802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108772_0_0_3"/>
    <dbReference type="OMA" id="QAFWNCP"/>
    <dbReference type="OrthoDB" id="1822700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103012">
        <property type="term" value="F:ferredoxin-thioredoxin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024707">
        <property type="entry name" value="FTR_bsu_Cyanobacter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113">
        <property type="entry name" value="PTHR35113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000260">
        <property type="entry name" value="FTRc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="SSF57662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 15 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="site" description="Increases the nucleophilicity of the active site Cys" evidence="18">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="19">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000260-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000260-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000260-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000260-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFZ52875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13045" checksum="2FCDDD9B6170DC7B" modified="2013-03-06" version="1">MTEAKNQKTLEAMKNFAEQYAKRTGTYFCAEPSVTAVVIQGLARHKEELGSPLCPCRHYEDKEAEVKDTFWNCPCVPMRERKECHCMLFITPDNEFAGEQQEISWEDLNSATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U6</accession>
    <name>K9Z2U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate ABC transporter, ATPase subunits C and D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Nitrate/nitrite/cyanate uptake transporter (NitT) (TC 3.A.1.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219208.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1365"/>
    <dbReference type="EnsemblBacteria" id="AFZ53479">
        <property type="protein sequence ID" value="AFZ53479"/>
        <property type="gene ID" value="Cyan10605_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1365"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1440"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025127_1_1_3"/>
    <dbReference type="OMA" id="PEAHIGQ"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="665" mass="74550" checksum="4963346AB5F57BE7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W7</accession>
    <name>K9Z2W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0942"/>
    <dbReference type="EnsemblBacteria" id="AFZ53072">
        <property type="protein sequence ID" value="AFZ53072"/>
        <property type="gene ID" value="Cyan10605_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0942"/>
    <dbReference type="eggNOG" id="ENOG5033A3N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205405_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="40" mass="4497" checksum="12789D88F5D510CD" modified="2013-03-06" version="1" precursor="true">MDVKMLMVILTGLFIVSALFFGTRNGYYDTDYYDGNGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z340</accession>
    <name>K9Z340_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1517"/>
    <dbReference type="EnsemblBacteria" id="AFZ53626">
        <property type="protein sequence ID" value="AFZ53626"/>
        <property type="gene ID" value="Cyan10605_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1517"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1612"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="EIFGYRY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="381"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="642" mass="73929" checksum="AC022ED94F0EC261" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z372</accession>
    <name>K9Z372_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ53167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1041"/>
    <dbReference type="EnsemblBacteria" id="AFZ53167">
        <property type="protein sequence ID" value="AFZ53167"/>
        <property type="gene ID" value="Cyan10605_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1041"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1102"/>
    <dbReference type="eggNOG" id="ENOG50338GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="INKRQDQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
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        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Nif11" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="12680" checksum="D3FCA57ACD3CFF0F" modified="2013-03-06" version="1">MSQEAVISFLDAVPQNEELQRKLATILESSENDREDAAQLANEYGYDITPDELWAEIQKRQQETKFRQEAGELTDEELEAVAGGELLVATIASTVAMTVSVGGSIAVGILAPKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B2</accession>
    <name>K9Z3B2_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1535"/>
    <dbReference type="EnsemblBacteria" id="AFZ53644">
        <property type="protein sequence ID" value="AFZ53644"/>
        <property type="gene ID" value="Cyan10605_1535"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="14973" checksum="5B564FE3F7BE7563" modified="2013-03-06" version="1">MITYVVDTHALAWFISEDERLSCKAKEILTQAENGEVKVLIPTLVMAELTHIAEKGKVKIIIEELLDKINQGDGFSIVGFDFVIFQQMLILPKHWDIHDRIIAATASYYQSTLITRDQILGNFPNLKTIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G7</accession>
    <name>K9Z3G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218654.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0790"/>
    <dbReference type="EnsemblBacteria" id="AFZ52923">
        <property type="protein sequence ID" value="AFZ52923"/>
        <property type="gene ID" value="Cyan10605_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0790"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.831"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="RIMNECE"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="310"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="450" mass="51092" checksum="764E331BDE055C31" modified="2013-03-06" version="1">MFEKETYDLLIVDDIAENIKVLANILTHSNYNVRKALSGKVALRSIKSSPPDLILLDIKMPEMDGYQVCQILKEDPETKSIPIIFISALNEVFDKVRAFQMGAVDYITKPFQIEEVIARINNQLTIQKQKKLLQQEIEKRKETEEILYQSRALLASILNTSLDGIVALQAVRKPLSTHIDDFRCLVVNPVFAKIINRHRDDLVGKLVGKKIMSKIDPNLFSKLVDVVDNGGVLAEDICFKQNNQSRWYHFIATKLGDGFSVTIRDITRRKKMELQLESLAKIDALTAIANRRQFDEIIAHEWQRHQRQQQPLTLIIADVDNFKAYNDNYGHPQGDECLYQIAQGISRSVKRAGELVARYGGEEFAIILPNTSPQKAINLAKLIQKNIKELQIIHEYSPTNEVITLSLGIVTMIPSLNSGYERMINIADKALYQAKNSGKNKIVIAKPELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J3</accession>
    <name>K9Z3J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1187"/>
    <dbReference type="EnsemblBacteria" id="AFZ53307">
        <property type="protein sequence ID" value="AFZ53307"/>
        <property type="gene ID" value="Cyan10605_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1187"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_0_3"/>
    <dbReference type="OMA" id="INWSFHR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="14159" checksum="360FD5F69A02F1F5" modified="2013-03-06" version="1">MKATVFKTNQSSLGNSMIDQRKILAEVKNFTQELYQDKLDKIILFGSRARGDYRQDSDVDILIVLKNDFHYSQEIEKTSDFIAKLSLNYDMVISRSFTNSFDYRNSKTPFFLNVRREGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U7</accession>
    <name>K9Z3U7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0052</name>
        <name evidence="3" type="ordered locus">Cyan10605_1118</name>
        <name evidence="4" type="ordered locus">Cyan10605_1500</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217945.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52213">
        <property type="protein sequence ID" value="AFZ52213"/>
        <property type="gene ID" value="Cyan10605_0052"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53240">
        <property type="protein sequence ID" value="AFZ53240"/>
        <property type="gene ID" value="Cyan10605_1118"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53611">
        <property type="protein sequence ID" value="AFZ53611"/>
        <property type="gene ID" value="Cyan10605_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0052"/>
    <dbReference type="KEGG" id="can:Cyan10605_1118"/>
    <dbReference type="KEGG" id="can:Cyan10605_1500"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101320_2_2_3"/>
    <dbReference type="OMA" id="WNCKYHV"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16270" checksum="8A863336AA972645" modified="2013-03-06" version="1">MQLGDCVLKPRKSSHSVFSVHLHLVFVTHYRRKVLTKEMIVRLGEMLEQVAKKLDCFILEFNGEPDHVHILLDLHPKNAISTVVACLKSSTARMLKKEFPQEVKKYYWGKVSFWSGSYYVASTGGATIEKLKEYIKNQEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z445</accession>
    <name>K9Z445_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219693.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1866"/>
    <dbReference type="EnsemblBacteria" id="AFZ53966">
        <property type="protein sequence ID" value="AFZ53966"/>
        <property type="gene ID" value="Cyan10605_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1866"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1979"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046116_2_0_3"/>
    <dbReference type="OMA" id="RTSWCQL"/>
    <dbReference type="OrthoDB" id="1753304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="51520" checksum="2DAE8328172F95F5" modified="2013-03-06" version="1">MNKYSRLQQFRFDTHQMLVKSKDAAFQLMDSIMATENARSLAEFSLSPFFHRQWSSTYEAIEDCRPNGNKFMRRYIQEIPILEYFLFGIDHTRWEFEDSPTMKDRTYQYSHCSVHSSVIGQGYSTIAWLPQLDHQGSWTLPLRHERITSFETPLNKATWQLKQVCQKLPSNIPKLVVLDCEYGNATFLKQTANVKVSKLIRVRSNLCFYGNPEPYSGRGRPKKHGDKWKLNESDNFPCADEVLEMEDPSLGQIRVSKWTQLHFYNAPLQTLTLLKIERLNPKKTGSKHRPLWLIWVGEEFLSLEKIWSQYSRRFGVDHWYRFAKQRLHWTLPNFRTPIQCQRWSDLIVNITWQLWLSKDLVQEHHLPWQKPQENLTPQRVARSMISLLMEIGSPTQTPKSRGKSNGWQKGRKRNKAKVYPTIKKRQSKSKKRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z457</accession>
    <name>K9Z457_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1817"/>
    <dbReference type="EnsemblBacteria" id="AFZ53919">
        <property type="protein sequence ID" value="AFZ53919"/>
        <property type="gene ID" value="Cyan10605_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1817"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573326_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="53817" checksum="6ED0877679F15A9F" modified="2013-03-06" version="1">MVDETTSSFAMTENAEDELASVVAVKKGSLPKFYLNVFKRRWLIILTFAVSGFVPAFLWSKTDPVIYPGSFKMLVEPVTSAEKLTEPTTLARTGGNVNEELLSIDYPTILRILKSNNILQQIAEKVNQNNPLYPPAYLIKTFQKDLGLTPAESLSASTLSQDPKRQRLLLDLQAIDTQIAQQSAQLTENHPNTLNLQDQKDNITNLLEKETTRVLQENKIDPNVNPRVFAYQDSSRLALIQKLIETQNQIDTLSSRYQSLKNSQTQTGSQLAVMPGVIKEYNDLDRQISLDTTILNQLTNQRETLGVEIAQKQIPWQILSPPQTAIDEFGNLKGYSPEPEKKLALGTGLGTILGLLVAIALEKRRDIIHETSDLEYAFGLPILGVVELEEKKKDQVTLEEENFFRDSKNVYQKITPVHISLSQVYTNLHFQLPNSHQNRILITSLHPTLRKTFTFKFRSCSKFSRSNCTTLCFDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z471</accession>
    <name>K9Z471_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219716.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1892"/>
    <dbReference type="EnsemblBacteria" id="AFZ53991">
        <property type="protein sequence ID" value="AFZ53991"/>
        <property type="gene ID" value="Cyan10605_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1892"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2008"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_3"/>
    <dbReference type="OMA" id="ADTFRRN"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="585" mass="67324" checksum="5CD21569E40BDB76" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z475</accession>
    <name>K9Z475_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219721.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1898"/>
    <dbReference type="EnsemblBacteria" id="AFZ53996">
        <property type="protein sequence ID" value="AFZ53996"/>
        <property type="gene ID" value="Cyan10605_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1898"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_0_3"/>
    <dbReference type="OMA" id="RPMDERI"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12421" checksum="288940B4631B2F40" modified="2013-03-06" version="1">MIHPQLEEIISKLKQSFINLYNTKLDKIILYGSQGRKDAQIHSDIDILVVLKGNIDPYKEIDRTGDIIYQISLDYDVVLSRHFISSDKFNHNNNPFLHNVKKEGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z484</accession>
    <name>K9Z484_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
            <ecNumber evidence="9">2.1.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EC" id="2.1.1.151" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219124.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1280"/>
    <dbReference type="EnsemblBacteria" id="AFZ53395">
        <property type="protein sequence ID" value="AFZ53395"/>
        <property type="gene ID" value="Cyan10605_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1280"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1352"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_3"/>
    <dbReference type="OMA" id="MEYPVTT"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="27473" checksum="2534B5B6CD2C4C6E" modified="2013-03-06" version="1">MNSRIGTLYGVSVGTGDPELITIKALKVIKNSPIIAFPAGINQKLGKAETIIQNYLQPHQKKLSLTFPYTLSQEILERSWRKVALQVWEFLAKGLDVAFACEGDISFYSTFTYLAEYIKKIDSNLRIERIAGVSSPMVAASVLDIPLTVQDEKLVVLPAFYSVEELEKVLDWAEVIVLMKVASVYEKVWQILAQKGLLSSSYIVEKATQPEEKVYRNLTLLPHLKLNYFSILIIKNNPHNTQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B8</accession>
    <name>K9Z4B8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpE</name>
        <name evidence="14" type="ordered locus">Cyan10605_1940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219761.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1940"/>
    <dbReference type="EnsemblBacteria" id="AFZ54036">
        <property type="protein sequence ID" value="AFZ54036"/>
        <property type="gene ID" value="Cyan10605_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1940"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2061"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_3"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="233"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="57312" checksum="08CAD80E95A779A2" modified="2013-03-06" version="1">MIFPDFSAFSNLVHQGNFIPVYRELVADLETPVSAWYKVCADQPHSFLLESVEGGENLGRYSFLGCDPVWILEARGNQTKQVHRDGKIETFSGNPFNILSQCLETIKPVKLPELPPGIGGLFGYWGYELISWIEPRVNVYPASAESLPDGIWMQVDNLLIFDQVKRKIWAIAYADLRQEHLSLEEIYNQACDKISKLVLKLQLPLPVSAKPLEFNPPPKTQKNHRIQYKSNTSKEAFCANVEKAKEYIKAGDIFQVVISQKLQSHYQGHPFELYRSLRLINPSPYMAYYNFHGWQLIGSSPEVMVKAEKTNDGKTKAVVRPIAGTRPRGRNYQEDQFLAQDLLNDPKERAEHVMLVDLGRNDLGRVCVKGSVEVDELMVIERYSHVMHIVSNVVGELAGDYCAWDLLKAAFPAGTVSGAPKIRAMEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRTMVVETLSGTENHLVSVQAGAGLVADSDPDKEYQETLNKARGLLEAISSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D2</accession>
    <name>K9Z4D2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">clpB</name>
        <name evidence="14" type="ordered locus">Cyan10605_1101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218954.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1101"/>
    <dbReference type="EnsemblBacteria" id="AFZ53223">
        <property type="protein sequence ID" value="AFZ53223"/>
        <property type="gene ID" value="Cyan10605_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1101"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1164"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_3"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="414"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="873" mass="99025" checksum="6DFBB04FD1B3A4E5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H0</accession>
    <name>K9Z4H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219359.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1523"/>
    <dbReference type="EnsemblBacteria" id="AFZ53632">
        <property type="protein sequence ID" value="AFZ53632"/>
        <property type="gene ID" value="Cyan10605_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1523"/>
    <dbReference type="eggNOG" id="ENOG50340SH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140918_0_0_3"/>
    <dbReference type="OMA" id="NINIEMG"/>
    <dbReference type="OrthoDB" id="1879941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="237" mass="27662" checksum="607C8B06CCD2E295" modified="2013-03-06" version="1">MKIPFPNNFEPQKPLKIYDYQDITIIIFAKSLKPNQLSLVNLYQQGIIPPHWQLKEPVVCKPHSFQLSFHEGININIEMGKVSFSYKKKAHSNSLDIIVNNFIAKIISYQFQRFQIVFRRLITFPKGKCSGLNFINNNLLSLQESRIQVNSISPHKIQLNFVYKLENQPLLISVIDTPVIKKKNNYSGLLFRGLINDENTKRLNRNKYQDNHSGSNIISNYPKYLDFFNQIVNSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M3</accession>
    <name>K9Z4M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219856.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2042"/>
    <dbReference type="EnsemblBacteria" id="AFZ54131">
        <property type="protein sequence ID" value="AFZ54131"/>
        <property type="gene ID" value="Cyan10605_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2042"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2169"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_2_3"/>
    <dbReference type="OMA" id="RDSFCDS"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="38227" checksum="E13125AC6C0CA463" modified="2013-03-06" version="1">MRNFNYFFRLIIGFFLISCTRNTSTSISNNNDDNCRSISHQMGEAKICDEPKRIVALGPNVLEPLLALQVQAIAFADHIGFYTKDYTNPLEQIPYLGKYINESMTNVGIAYTPNIEQILKVKPDLILGVEINNASQYEMLSKIAPTLILDWDKPMENMKTIAQAVNRETQAEELLQTTQAQIAKAKTEFAPVVKKHPKVLLLYAKGLQELISDNSRGLCSSLVKDLGFQLVSPPKSNPSQPDTRTPISLEILPQLEKADSIILLGYNFSQPETLKDIDNFAQHQLTETQQAWAKNEIAQSLEASKEGRVYYIPAYMCLGLTGAIGTELYLNELKTQLLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M4</accession>
    <name>K9Z4M4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219264.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1424"/>
    <dbReference type="EnsemblBacteria" id="AFZ53535">
        <property type="protein sequence ID" value="AFZ53535"/>
        <property type="gene ID" value="Cyan10605_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1424"/>
    <dbReference type="eggNOG" id="ENOG5033IKC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600194_0_0_3"/>
    <dbReference type="OrthoDB" id="2232472at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="8876" checksum="5FE0925821EBAAB6" modified="2013-03-06" version="1">MNNNFFDPGQNSGNVNDFSADNEVEKISPQKKKEIQKLFIILLAIGLVIGIFTAWGVVTIMNNFGLTEKTNQFEKFHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R1</accession>
    <name>K9Z4R1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolate oxidase, subunit GlcD</fullName>
            <ecNumber evidence="3">1.1.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219122.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1278"/>
    <dbReference type="EnsemblBacteria" id="AFZ53393">
        <property type="protein sequence ID" value="AFZ53393"/>
        <property type="gene ID" value="Cyan10605_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1278"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1350"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_3"/>
    <dbReference type="OMA" id="TPRTCGE"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009339">
        <property type="term" value="C:glycolate oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004490">
        <property type="entry name" value="GlcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00387">
        <property type="entry name" value="glcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="488" mass="52668" checksum="EC6834EC69465322" modified="2013-03-06" version="1">MFLSSIDNKWQPIIKKLESVLGKNGVVKRKDELLTYECDGLPQYRQRPALVTLPKTTEEVAEIVKVCNQYEIPWIARGAGTGLSGGALPVEDCVLIVTARMRQILDIDYDNQRIIVQPGIINNWVTQAVSGAGFYYAPDPSSQIICSIGGNVAENSGGVHCLKYGTTTNHVLGLTIVTAEGEILKIGGKVPETPGFDLTGLFVGSEGTLGIATEITLKILKTPESICVVLADFQSVEDAGKAVAGIIQAGIIPAGMEMMDNFSINAVEDVVATDCYPRNAEAILLVELDGLEVEVKNYKEKVAEICRQCGAGSITSANDQETRLKLWKGRKAAFAAMGKISPNYFVQDGVVPRSKLPQVLAEINQLSEKYGYRIANVFHAGDGNLHPLILYNGAVEGAFETVEELGGEILKLCVRVGGSISGEHGIGSDKKCYMSDMFTETDLETMQYVRSSFNPKGLANPTKIFPTPRTCGESANAQKTEYKGAIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T8</accession>
    <name>K9Z4T8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219464.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1630"/>
    <dbReference type="EnsemblBacteria" id="AFZ53737">
        <property type="protein sequence ID" value="AFZ53737"/>
        <property type="gene ID" value="Cyan10605_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1630"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1730"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_1_0_3"/>
    <dbReference type="OMA" id="SIMETNY"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="9916" checksum="3D1B0B8C0C7C9D20" modified="2013-03-06" version="1">MDVITYTQARKNFTHVMNEVCENHTPIIITRQSAKPVVMMSLEDYSAIEETLYLLRSPKNAQRLYKALGELKQGKYESHELIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U2</accession>
    <name>K9Z4U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54164">
        <property type="protein sequence ID" value="AFZ54164"/>
        <property type="gene ID" value="Cyan10605_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2075"/>
    <dbReference type="HOGENOM" id="CLU_1493857_0_0_3"/>
    <dbReference type="OrthoDB" id="1998845at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="21375" checksum="172DC43E9CEEFFE2" modified="2013-03-06" version="1">MNKYYSLVVFGNNKRVNLKKLNRELELQKSQCLEFFKNQIEININFLDSTITSFSEINNLLGNLKGDVFILLKIEYYPKDSWLKNIITSFDKSHHSILIGKITENNLLFNWFKQEKNNQEDIVNEIEKYIGNCALKKSFIEPILCLKSAYNEREKSCYKRIFREVETEILYLENVEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y0</accession>
    <name>K9Z4Y0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219909.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2095"/>
    <dbReference type="EnsemblBacteria" id="AFZ54184">
        <property type="protein sequence ID" value="AFZ54184"/>
        <property type="gene ID" value="Cyan10605_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2095"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815636_0_0_3"/>
    <dbReference type="OrthoDB" id="1908236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="39950" checksum="C9685E4505D60E20" modified="2013-03-06" version="1">MIDWHNFFLGILLWLGGSGFLLTLMRDKSSSEMSSTESLLISRNERILELEKQLLEAKEELNSANQRIDTLCAELERNSQEQNQLIQELELEKQELRSQNASARSQLRSLENQLKEKINELDNAYTEIELWHQQVEKINTDLPDREDDSQTQIEILEKQLKEQLNNLEESRNNIKEIEQELAQTNDELEQTQDELSFSQKESKELKNKIQELNSQCEQLNQKLEKLPLELEANWQEQLFNSLQYLFVNYPIAKMVAKLKPNTNIKNFITLLKPIDDLLKQWQIEPIGKPWEKVSFNPEIHYNEEEKLVTAEEVYIRLVGYKQGKKVLTKAKVSRQLPGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z509</accession>
    <name>K9Z509_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219227.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1385"/>
    <dbReference type="EnsemblBacteria" id="AFZ53498">
        <property type="protein sequence ID" value="AFZ53498"/>
        <property type="gene ID" value="Cyan10605_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1385"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077957_0_0_3"/>
    <dbReference type="OMA" id="TMASEFR"/>
    <dbReference type="OrthoDB" id="1569918at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="33656" checksum="90AECAF85571A05A" modified="2013-03-06" version="1">MSELSDSLNLLSQLIMEFPERLENLITLAQEVEAEANELVANVQEKQAQVAETLGEVQGALTQMQQEIADNQTETETAVNEFESSATELGNFMTQAQEEMVQELQTAMEKMNQLKTNLEEGKASTEATEETAQNAMKESQTALQASQEQLRSAFESSLSAMEALREKLEDVSSRMDEEMQNFSEQVNQGQETVSGEIQTMADEFTSIGENFTSVLSSTSEAISGGVSGLMDKAQSEIEAQLQELIASAVSKVTDSVEDMVQKVTDAESESSGIREVVAGLIDDLDAFKEPVEAGIDGVKSAAEKFGIDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z529</accession>
    <name>K9Z529_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219247.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1406"/>
    <dbReference type="EnsemblBacteria" id="AFZ53518">
        <property type="protein sequence ID" value="AFZ53518"/>
        <property type="gene ID" value="Cyan10605_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1406"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1486"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_0_3"/>
    <dbReference type="OMA" id="YVRQEQT"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="12099" checksum="EE8E2B9CD50A0E48" modified="2013-03-06" version="1">MTLTVKKNKLDILKENIKKIKLEIEEEYQIDELGLFGSYVRGEETENSDIDLLVTFKPEARFGLAKYGKLQNLFSDRLGKKVDLVMKKGLKPHIGKQILSEVIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z533</accession>
    <name>K9Z533_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ordered locus">Cyan10605_1750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219579.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1750"/>
    <dbReference type="EnsemblBacteria" id="AFZ53852">
        <property type="protein sequence ID" value="AFZ53852"/>
        <property type="gene ID" value="Cyan10605_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1750"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1857"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_2_1_3"/>
    <dbReference type="OMA" id="IGNSRWH"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="28107" checksum="822211B14F3E0E88" modified="2013-03-06" version="1">MENWLGLMIGNSRLHWAYFQGKELRKTWNTLSADTVKELEAVLDEELFGHIQSRMSLYVASVVPSATKIYLSLPQTIIINYQKIPLHNIYDSMGCDRILALWGGGCHYGFPCLVIDSGTALTFSGADEKQNFQGGAIMPGVRLQLQTLFFNTAALPEVQIMGEITPRWATNTPCAIQSGVVYTIVAGIKDFAQDWFKKYPQSKVVLTGGDALLLSRYLADIDPDFSQKLIIDPDLIFWGMQYYQSAIEFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z583</accession>
    <name>K9Z583_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219629.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53902">
        <property type="protein sequence ID" value="AFZ53902"/>
        <property type="gene ID" value="Cyan10605_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1800"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044172_1_0_3"/>
    <dbReference type="OMA" id="DYIPAND"/>
    <dbReference type="OrthoDB" id="856631at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="470" mass="55101" checksum="17EB5548A3F57347" modified="2013-03-06" version="1">MGKDYQGYNDILEYFKYIKSQMPKGISLFKRGNKLYFLFKTQYKKRSDHATGENFTTLGLNRCLEKAIQINEQLKGYESEIEFWAWYDETIKGINQNATNDLITVANAINKVESWFFSQNDRRGLQRSKETDYKSYKRAYGYYYQKIHNQEKQVSYELLYDSLISYESDRETQKYQECLNAFLKLCEVNQLKTIYNKLSKLKLKTNAKKKNTFNREEQSISIEDFLKLRVAVLSIKDSHSLRENNRKFWLWVYSIQLVYGLRIAEVAAIKNLTRDYIPANDPQENSKDKTIFKALNNPDNKDNIIYIGNFTLWGNQKVKTGARIAMPLIPPTYPNIIDLLEIKNVPNFYHKSFNIYSRNANQRIEQWSTKFLGYKVSQTHTLRKLGNANGIQAGISDTVRCKSLGHSETVNAKYYQDFSGQTTIDLYKNAKRNPIPFETALKLLDDLPTNPKKEDLIKLLCQIYQLQYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H1</accession>
    <name>K9Z5H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1888"/>
    <dbReference type="EnsemblBacteria" id="AFZ53987">
        <property type="protein sequence ID" value="AFZ53987"/>
        <property type="gene ID" value="Cyan10605_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1888"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2004"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094143_0_0_3"/>
    <dbReference type="OMA" id="RCKFVYA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="4">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="258" mass="28925" checksum="330372A7FD1C5228" modified="2013-03-06" version="1">MSNECSELLMINYSPQHPNTPTLFTITLFAITPMSENLSRTQITYLFRQIYNYDVELRLFNNMWQYKTPGIPDELFDRLPGIPMTKREVRLLILSGLRLEEKSVIWDIGAGTGTISIEIGLLCPNTKIIAIERDPEVAGLIRQNCRRFEVENVEVVEGNAPDCFDTLPEKPDRICIGGGKSIKNILTSCWGYLPEGGRLVATASNLENLYQISEGLAELRACNIEVVQSSINRLEKRGLSQVFAAIAPIFILSGEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H5</accession>
    <name>K9Z5H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1893"/>
    <dbReference type="EnsemblBacteria" id="AFZ53992">
        <property type="protein sequence ID" value="AFZ53992"/>
        <property type="gene ID" value="Cyan10605_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1893"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_3_2_3"/>
    <dbReference type="OMA" id="EDHTWVA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="32313" checksum="BD1A5DEF80BC376B" modified="2013-03-06" version="1">MKCTSIGLTDPGLVRPYNQDNHYTDPEGRFFILADGMGGHAGGEEASRIAVEVIREYLEANWDAPIDSYDLIEKSIYQANEGILEDQVLHPERADMGTTLVLVVFREDETWRAHVGDSRLYRWRNGELNQITLDHTWISQAIRAGEITPEDAKYHPWRHVLSQCLGRRDLYEGIDIQKMDDVQNGDRFLLCSDGLTEEVPDDLINKSLQELENLEQAAKTLIQNAKDGGGSDNITVVLVSVEGIENQSSEKNENSSIGETENQLLNENENLAVEETENKSIDDNENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H6</accession>
    <name>K9Z5H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyanobacterial porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219375.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1539"/>
    <dbReference type="EnsemblBacteria" id="AFZ53648">
        <property type="protein sequence ID" value="AFZ53648"/>
        <property type="gene ID" value="Cyan10605_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1539"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1634"/>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018575_1_0_3"/>
    <dbReference type="OMA" id="SHYAAVN"/>
    <dbReference type="OrthoDB" id="1383921at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939123" evidence="1">
        <location>
            <begin position="29"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="593" mass="63640" checksum="1BFCB04AA72B6D0B" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I6</accession>
    <name>K9Z5I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1722"/>
    <dbReference type="EnsemblBacteria" id="AFZ53825">
        <property type="protein sequence ID" value="AFZ53825"/>
        <property type="gene ID" value="Cyan10605_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1722"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1829"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_7_2_3"/>
    <dbReference type="OMA" id="FEWGKRR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="603" mass="67467" checksum="DDC3ECB61368CC13" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N8</accession>
    <name>K9Z5N8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219415.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1579"/>
    <dbReference type="EnsemblBacteria" id="AFZ53688">
        <property type="protein sequence ID" value="AFZ53688"/>
        <property type="gene ID" value="Cyan10605_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1579"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1676"/>
    <dbReference type="HOGENOM" id="CLU_137826_0_0_3"/>
    <dbReference type="OMA" id="GAGFRNW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026356">
        <property type="entry name" value="Cyano_gly_rpt_prot"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04260">
        <property type="entry name" value="Cyano_gly_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938605" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15016" checksum="F889A91362A32064" modified="2013-03-06" version="1" precursor="true">MIKTTNTTWMGFLLAISTVAYCGSSQATTADSIKESLNPLENRISRIAEELKEREKQLQQEGESDNNFTSDIDDNLIAGGWGNGRGGSWVDSNRGSFVNNRRGWDNWRGWDDWGRWTNRSPWRNGGGFLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V6</accession>
    <name>K9Z5V6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol dehydrogenase</fullName>
            <shortName evidence="5">HDH</shortName>
            <ecNumber evidence="5">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisD</name>
        <name evidence="12" type="ordered locus">Cyan10605_2448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220252.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2448"/>
    <dbReference type="EnsemblBacteria" id="AFZ54529">
        <property type="protein sequence ID" value="AFZ54529"/>
        <property type="gene ID" value="Cyan10605_2448"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2448"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2593"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_3"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5 7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9 10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9 10">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9 10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9 10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="430" mass="46490" checksum="BAB621D290CC3BCB" modified="2013-03-06" version="1">MLRIITDQGEARQELQRISERTYHENIETQSATVREIIATVKKNGDRALLEYTEKFDGQVIPPEKLKVSGSEIDAAYQQISPDLLQAIKLAATKIEAFHQQRTPKSWVQFAEDNVVLGRRYTPVDRAGLYVPGGRASYPSTVLMNAIPAKVAQVPRIVMVTPPSEGGKINPAVLVAASEAGVTEIYRVGGAQAVAALAYGTETIPRVDVITGPGNIYVTLAKKEVYGRVGIDSLAGPSEVLIIADSQANPVHVAVDLLAQAEHDPMAAAILVTDSELLAQQVQAEVDQQLENHPRRTLTEKAIAHYGVIILTKNLTEAAELSNLFAPEHLELEVESPWDLLEHIRHAGAIFLGNSSPEAVGDYLAGPNHTLPTSGAARYASALGVETFMKYSSIIEYSPSALQKVSKAIIDLTIAEGLPSHGNSVKYRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V7</accession>
    <name>K9Z5V7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220294.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2490"/>
    <dbReference type="EnsemblBacteria" id="AFZ54571">
        <property type="protein sequence ID" value="AFZ54571"/>
        <property type="gene ID" value="Cyan10605_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2490"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2639"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_0_0_3"/>
    <dbReference type="OMA" id="VFFNFFN"/>
    <dbReference type="OrthoDB" id="1425262at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="385" mass="42821" checksum="FC1B83EA2FC4C97C" modified="2013-03-06" version="1">MTNITFSQVRQEQKRKILIEIAIAVGAIIILSLILPLILSPFRLQLLGRFLALTIVALGIDLIWGYTGLLSLGHGIFFALGGYGIAMHLKLQLPDGQLPEFFTLYGVSDLPWFWKPFYSFPFTVVAIFVIPAIVAGILGYLVFRNRIKGVYFSIITQAALIVFFNFFNGQQKLINGTNGLKTDTETIFGVVASSQTAQFAFYQFTILFLLLAYLLCRWLTSGRFGRLLIAIRDDENRVRFSGYNPTGFKVLVFAVSGAIAGISGALYTLQTGIITPSIMEVAFSIEMVIWVAVGGRGTLLGAIIGTLLVRFGQTFLSEEFPEIWLFFQGALFLMVVTVLPDGIVGWWNNWAWIKLKSVLGLQPKLSTYPAIEQNPEVEMEKENIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W7</accession>
    <name>K9Z5W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220304.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2500"/>
    <dbReference type="EnsemblBacteria" id="AFZ54581">
        <property type="protein sequence ID" value="AFZ54581"/>
        <property type="gene ID" value="Cyan10605_2500"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2500"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2650"/>
    <dbReference type="eggNOG" id="COG4245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082324_1_0_3"/>
    <dbReference type="OMA" id="MHGEPIE"/>
    <dbReference type="OrthoDB" id="1369887at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="25595" checksum="4D9B735E1A9C400E" modified="2013-03-06" version="1">MSNLKKFTVHSPRKLPVIILADVSGSMESNGKIQTLNRAIASMIDSFAQEEDVRAEINVSVITFGGEKAQIHIPLQPAEKIEWQDMSAMGRTPMGNAFGVAQAMVEDRSIIASRDYHPTIILVSDGIPTDEWIPPLNNLITSERASKALRLSMAIGAEADNEPLQSFLQNQHPEIPVFRADEANQIKQFFRFVTMTITNASKSVNPNSIPVLNFDALDNFDDLDDEYTGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z672</accession>
    <name>K9Z672_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO and MBR like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219800.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1980"/>
    <dbReference type="EnsemblBacteria" id="AFZ54075">
        <property type="protein sequence ID" value="AFZ54075"/>
        <property type="gene ID" value="Cyan10605_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1980"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2100"/>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106271_0_0_3"/>
    <dbReference type="OrthoDB" id="1679387at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="25798" checksum="B0435E8827E641E4" modified="2013-03-06" version="1">MTNNWFSGTVNTVMGVKKESQNNNQENIPLNGKKIVSYLAGTLAQIGLMILTLWLANKGFESLIKYNLNEKINISIVCLFLTFFTIRSRFFSPLDNTRSRRQYDQVIRPKWAPPPFVFPIVWMSIGVLRIVSSYLVWQKLDQNFLAIPLIVFAIHLALGDTWNTIFTVEGRYALAVPVVILGPLLSSIILAVLYGQIIPLAGWLIFPSCVWLVVASALVTRIWQLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z683</accession>
    <name>K9Z683_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219962.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2151"/>
    <dbReference type="EnsemblBacteria" id="AFZ54237">
        <property type="protein sequence ID" value="AFZ54237"/>
        <property type="gene ID" value="Cyan10605_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2151"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2285"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_8_3"/>
    <dbReference type="OMA" id="FHIDRWW"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="584"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="874"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1047" mass="120321" checksum="7C8077C8EAB7EC3E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A6</accession>
    <name>K9Z6A6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ordered locus">Cyan10605_2632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220429.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2632"/>
    <dbReference type="EnsemblBacteria" id="AFZ54706">
        <property type="protein sequence ID" value="AFZ54706"/>
        <property type="gene ID" value="Cyan10605_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2632"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2796"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_4_0_3"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="45379" checksum="5F635B1F654D7EFB" modified="2013-03-06" version="1">MDTKTFKRTLQQSDNYHRKGFGHQEEVTLTLNQEYQSNLIQTIRQNNYQITQGNVTIRLAEAFGFCWGVERAVAMAYETRTHFPTEKIWITNEIIHNPSVNKRLREMNVDFIPVDNGVKDFSVVNPKEVVILPAFGASVSEMQLLNDKGCTIVDTTCPWVSKVWNSVEKHKKKEYTSIIHGKYKHEETVATSSFAGTYLVVLNMKEAQYVCNYILNGGDKLEFLNKFKNAYSEGFDPDVDLVRVGIANQTTMLKSETEAIGKLFEQTMIKKYNPAELNQHFMSFNTICDATQERQDAMLDLVEEKLDLMVVIGGFNSSNTTHLQEIAIENQIPSYHIDSCDRILEGNRIEYKPLDKDLEIQENWLPEGKITVGITSGASTPDKVVEDVIEKIFALKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A7</accession>
    <name>K9Z6A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219835.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2016"/>
    <dbReference type="EnsemblBacteria" id="AFZ54110">
        <property type="protein sequence ID" value="AFZ54110"/>
        <property type="gene ID" value="Cyan10605_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2016"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2142"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015930_0_0_3"/>
    <dbReference type="OMA" id="AKVGYWL"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="AMIN" evidence="8">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="177"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="377"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="851" mass="94279" checksum="6AD998DB389C8E74" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B2</accession>
    <name>K9Z6B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219840.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2021"/>
    <dbReference type="EnsemblBacteria" id="AFZ54115">
        <property type="protein sequence ID" value="AFZ54115"/>
        <property type="gene ID" value="Cyan10605_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2021"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2148"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_3"/>
    <dbReference type="OMA" id="HEDEDYW"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="AMIN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="187"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="369"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="834" mass="94327" checksum="359E6C3A7464F401" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G9</accession>
    <name>K9Z6G9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220504.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2708"/>
    <dbReference type="EnsemblBacteria" id="AFZ54781">
        <property type="protein sequence ID" value="AFZ54781"/>
        <property type="gene ID" value="Cyan10605_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2708"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_6_1_3"/>
    <dbReference type="OMA" id="HNSTELK"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="11933" checksum="B8A74A44C9DDB491" modified="2013-03-06" version="1">MLSKVKVIRPDGMLDANKAVVFRQQIKDLVSEGINLILIDLKKVNFMDSSGLGALVLALKMVREKGGRLFLMSLNDQVKMLFELTNTGHLFEIINDKSELEEKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I5</accession>
    <name>K9Z6I5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220524.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2729"/>
    <dbReference type="EnsemblBacteria" id="AFZ54801">
        <property type="protein sequence ID" value="AFZ54801"/>
        <property type="gene ID" value="Cyan10605_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2729"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2895"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_3_0_3"/>
    <dbReference type="OMA" id="WQMMLRL"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011787">
        <property type="entry name" value="SiR_ferredoxin-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02042">
        <property type="entry name" value="sir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="10">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="9">
        <location>
            <begin position="165"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="10">
        <location>
            <begin position="362"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="9">
        <location>
            <begin position="445"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="643" mass="73534" checksum="2EB4A0FF48AE02F4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J2</accession>
    <name>K9Z6J2_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2086"/>
    <dbReference type="EnsemblBacteria" id="AFZ54175">
        <property type="protein sequence ID" value="AFZ54175"/>
        <property type="gene ID" value="Cyan10605_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2086"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1724350at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="205" mass="24776" checksum="036A5F0423244943" modified="2013-03-06" version="1">MNGNNIFFSDLNHELLIPLHKESDIFLWKKWQSNPSQARYLVEIFIRYHKLINDSQENDIDKVTLDKYYKQIWFYIIDNLLEYPISKDTILRDVIFTLSKNFFQEHNVIYKSFYLSPIDYDLLKKYIPLIYFLNKSLNKLNSLERLTIVAIDKFGWQEEKLIEYLRQHQQNLTIPELKSYYTKGYSNLINNLPTDIIAIYLQNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M1</accession>
    <name>K9Z6M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220121.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2313"/>
    <dbReference type="EnsemblBacteria" id="AFZ54397">
        <property type="protein sequence ID" value="AFZ54397"/>
        <property type="gene ID" value="Cyan10605_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2313"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2457"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108879_10_0_3"/>
    <dbReference type="OMA" id="RDKYQCQ"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
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    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
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    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9915" checksum="CB5308CB8E360D66" modified="2013-03-06" version="1">MRNNIKTERINIPLSVRKYIYERDKFQCQSCGKKENETQLNIDHIIPLAKGGSNDLSNLQTLCYQCNQRKKANFDPRFRRYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M7</accession>
    <name>K9Z6M7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220568.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2779"/>
    <dbReference type="EnsemblBacteria" id="AFZ54846">
        <property type="protein sequence ID" value="AFZ54846"/>
        <property type="gene ID" value="Cyan10605_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2779"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2952"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369128_0_0_3"/>
    <dbReference type="OMA" id="GGYPDHF"/>
    <dbReference type="OrthoDB" id="412318at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="514"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="775" mass="88255" checksum="3E46AE4F31B74E23" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N1</accession>
    <name>K9Z6N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CpcD phycobilisome linker domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cellular thylakoid membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219930.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2116"/>
    <dbReference type="EnsemblBacteria" id="AFZ54205">
        <property type="protein sequence ID" value="AFZ54205"/>
        <property type="gene ID" value="Cyan10605_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2116"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2249"/>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173132_1_0_3"/>
    <dbReference type="OMA" id="YSRMNEE"/>
    <dbReference type="OrthoDB" id="2009463at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008213">
        <property type="entry name" value="CpcD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01383">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01094">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51441">
        <property type="entry name" value="CPCD_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="2 3" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CpcD-like" evidence="4">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="9467" checksum="A5271904BC2131E9" modified="2013-03-06" version="1">MLSTLVSGSSYSPAKNRVFVYEVTGLKQSGENDKNNYAFRKSGSVFIQVPYARMNEEMQRINRMGGKIINISPLVISEGGSGDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q0</accession>
    <name>K9Z6Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Farnesyl-diphosphate farnesyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219803.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1983"/>
    <dbReference type="EnsemblBacteria" id="AFZ54078">
        <property type="protein sequence ID" value="AFZ54078"/>
        <property type="gene ID" value="Cyan10605_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1983"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2104"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_1_0_3"/>
    <dbReference type="OMA" id="DLDRYTF"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004310">
        <property type="term" value="F:farnesyl-diphosphate farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="270" mass="30498" checksum="5817BD50F964D69E" modified="2013-03-06" version="1">MNLKKSALKTLKETSRTFYIPISRLPDSLQDAVTSAYLCMRAIDEIEDHPHIENNIKREILTQISASLQSISNDTAVEDITAYIEPYKHLLPEVSYRFAEWATLAPVSIAGRIWEATAAMSDRMAYWADKNWVIKTKADLDQYTFSVAGSVGLLLSDLWAWYDNTKTNREEAIAFGRGLQAVNILRNHQEDKLRGVSFFPEGWQLEDMHQYARYNLTLADSYTKSLPKGPALQFCQIPLTLAHATLDVLILGKPKLTRNDVMALVAQVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S7</accession>
    <name>K9Z6S7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="11" type="ordered locus">Cyan10605_2829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220618.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2829"/>
    <dbReference type="EnsemblBacteria" id="AFZ54896">
        <property type="protein sequence ID" value="AFZ54896"/>
        <property type="gene ID" value="Cyan10605_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2829"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3007"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_3"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="655"/>
            <end position="662"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="873" mass="97901" checksum="99F844DAB7089577" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T3</accession>
    <name>K9Z6T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2179"/>
    <dbReference type="EnsemblBacteria" id="AFZ54265">
        <property type="protein sequence ID" value="AFZ54265"/>
        <property type="gene ID" value="Cyan10605_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2179"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_3"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29701" checksum="3036562CEE54DB94" modified="2013-03-06" version="1">MNKDDPQITSPMIIAHRGSSKESPENTLSAFQLAISQGADGIEGDFHLTKDKQVVCIHDSNTARVANTKLIVKNSTLAELKKLDVGYWFNSTFKNEKIPTLNEVLEILPSDKKLFLEIKSDPDIVPYLLSILIDSKINLNQLVIISFNSRILRTIKQQKPELKTLFLVSLKTFNRIKLSNFLVKKLLNKLEDISADGISTSISNFLNETYIHQFISKGYEYHLWTIDNEKIAEQFIKIGVNSITTNTPKIIKQIKYFQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z744</accession>
    <name>K9Z744_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220285.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2481"/>
    <dbReference type="EnsemblBacteria" id="AFZ54562">
        <property type="protein sequence ID" value="AFZ54562"/>
        <property type="gene ID" value="Cyan10605_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2481"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2630"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038461_0_0_3"/>
    <dbReference type="OMA" id="NFKRGIG"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="59242" checksum="F7EB4FC6B6DF11C3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z763</accession>
    <name>K9Z763_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase HEAT domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220305.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2501"/>
    <dbReference type="EnsemblBacteria" id="AFZ54582">
        <property type="protein sequence ID" value="AFZ54582"/>
        <property type="gene ID" value="Cyan10605_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2501"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2651"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101012_0_0_3"/>
    <dbReference type="OMA" id="PDYGIRA"/>
    <dbReference type="OrthoDB" id="1113913at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="222" mass="24632" checksum="D94D0CA493565A45" modified="2013-03-06" version="1">MSQINLAEIDRQLESNNSKDRLLALASLREVEAKDAVPLIKKVIYDEMLPVRSMAIFALGVKQTEECLPILVKLLETDPDYGIRADAAGALGYLKDIRAFESLVRAFYEDTEWLVRFSAAVSLGNLGDIRAKKLLLDALHSNETALQQAAISALGEVKAEDCIEEILVFVQSDDWLIRQRVSESLGNFKGNKKAISALNFLVKDPHPQVCQAAEYSLQKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z769</accession>
    <name>K9Z769_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2986"/>
    <dbReference type="EnsemblBacteria" id="AFZ55046">
        <property type="protein sequence ID" value="AFZ55046"/>
        <property type="gene ID" value="Cyan10605_2986"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2986"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3180"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064678_0_0_3"/>
    <dbReference type="OMA" id="FTGHLHV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="360" mass="41606" checksum="0AF55E417BBD1FB4" modified="2013-03-06" version="1">MNIRFAIASDLHIALPETIDAEAKRFHLTQFSIPALEVVLQHLQNLNLDFLLLPGDLTQDGEILNHCWLKTQLEKLPFPVYVIPGNHDIPSIKGNEDIIAFQDFPLYYQKCGYQSATKNLDYTCEIAPNLQLVALNSNNFDRDGKQQGYLKDEQFSWLEQTLANLTDKLVLLMIHHNVIEHLPQQSTHILGRRYMLDNAPRLLSILEKYGVKLIFTGHLHIQDVAKYGDIQEITTGSLITYPHPYRILTLTRDRLIIESHHITKLPEMDDFAEFSQKWMGDRSFSFMMMMLTSPPLNLKEEKAKEYAPILRNFWADIAHGDKQFDFPQFPPEINKYFQAFGAIDEQGKPVKKDNNTIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z781</accession>
    <name>K9Z781_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220154.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2346"/>
    <dbReference type="EnsemblBacteria" id="AFZ54430">
        <property type="protein sequence ID" value="AFZ54430"/>
        <property type="gene ID" value="Cyan10605_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2346"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2490"/>
    <dbReference type="eggNOG" id="COG3211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018570_1_0_3"/>
    <dbReference type="OMA" id="WDVYLFG"/>
    <dbReference type="OrthoDB" id="796397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="717" mass="78921" checksum="125963A18C3C875A" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z792</accession>
    <name>K9Z792_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.17" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220335.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2532"/>
    <dbReference type="EnsemblBacteria" id="AFZ54612">
        <property type="protein sequence ID" value="AFZ54612"/>
        <property type="gene ID" value="Cyan10605_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2532"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="GSYGIAY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28801" checksum="F4655AAB32490E36" modified="2013-03-06" version="1">MELLVKNRYQAVKIIGEGGFGKTFLAIDTHSQNQYRCVIKQLLNTSTSSQSKNWQLFIAEIHRLQFLNTNPHIPKLIDFCEQDNNYYIIQEFIDGENLKLELNKQGIYSEKKIIKLLQEILPILKFIHDKSIIHRDIKPENIIRKIDNQQLYLVDFGASKLLSQQDPYKTATVIGSPEYVAPEQARGKTVFASDIYSLGVTCLSLLTERSPFDLIDLNNNWIWQEYTREKINKTLCKILNKMVCFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A4</accession>
    <name>K9Z7A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220345.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2542"/>
    <dbReference type="EnsemblBacteria" id="AFZ54622">
        <property type="protein sequence ID" value="AFZ54622"/>
        <property type="gene ID" value="Cyan10605_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2542"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2697"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010500_1_0_3"/>
    <dbReference type="OMA" id="SDFNWTG"/>
    <dbReference type="OrthoDB" id="393729at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022244">
        <property type="entry name" value="DUF3769"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12600">
        <property type="entry name" value="DUF3769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="775" mass="86195" checksum="90B55EBE9AF1BE90" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H3</accession>
    <name>K9Z7H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220813.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55094">
        <property type="protein sequence ID" value="AFZ55094"/>
        <property type="gene ID" value="Cyan10605_3037"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3037"/>
    <dbReference type="eggNOG" id="ENOG50333VT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174734_2_1_3"/>
    <dbReference type="OMA" id="VEHHPVK"/>
    <dbReference type="OrthoDB" id="2057405at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032568">
        <property type="entry name" value="DUF4926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16277">
        <property type="entry name" value="DUF4926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="8880" checksum="72AE80F27C4B597C" modified="2013-03-06" version="1">MNFALYSDVILLKDIVEDGLFAGDIGTVVDIHNVSGLETGYSVEFFDLLGNTRAVVTLPMSYFRQPTKSDIPTVRLLAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M4</accession>
    <name>K9Z7M4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGTPase</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220122.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2314"/>
    <dbReference type="EnsemblBacteria" id="AFZ54398">
        <property type="protein sequence ID" value="AFZ54398"/>
        <property type="gene ID" value="Cyan10605_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2314"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_3"/>
    <dbReference type="OMA" id="KLEYQFP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="15423" checksum="485EEC6BBF23D05C" modified="2013-03-06" version="1">MNKSHKHIGVAIIINDKKEILIDRRLPTGVMANLWEFPGGKIERGETPEDCIIREIKEELGVVVRCDRIFAEITHDYEQFTVTLYVYLCHICQGKPQPLECAEILWVKPHELSQFEFPSANQEIISKLQKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y8</accession>
    <name>K9Z7Y8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMP/dCMP deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220977.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3212"/>
    <dbReference type="EnsemblBacteria" id="AFZ55259">
        <property type="protein sequence ID" value="AFZ55259"/>
        <property type="gene ID" value="Cyan10605_3212"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3212"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3424"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_5_2_3"/>
    <dbReference type="OMA" id="MCHAAMR"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17640" checksum="92B70ED4535FE61B" modified="2013-03-06" version="1">MINDKDIEYMRQAIALMREAGVVKKTGGAFGTVVVKDGEVIGASGNSVLRDNDPTAHAEVNAIRQACKKLGTVDLSGAVLYSSCECCPMCYATAYWARISKIYYAAGWSDFADLFDDANIQEDLVKEYKNRLLAPEQILQEEAQAVWQEFRELPDGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z841</accession>
    <name>K9Z841_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221079.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3316"/>
    <dbReference type="EnsemblBacteria" id="AFZ55361">
        <property type="protein sequence ID" value="AFZ55361"/>
        <property type="gene ID" value="Cyan10605_3316"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3316"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3530"/>
    <dbReference type="eggNOG" id="ENOG5031TCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116763_0_0_3"/>
    <dbReference type="OMA" id="ERPYFQK"/>
    <dbReference type="OrthoDB" id="1744488at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="19235" checksum="06C554C8CABD4975" modified="2013-03-06" version="1">MTEEKKQDLDQDLELQKDIYQGREFTLADFIAKEGGDFLKGESPVPKIVQLKTEINFFIKNNLKDLSGSLQAVLQDWVNISDDKISSNRENPLNALSLIIEEIISNDNLYYEFVRQVDLKWGQMYQERPYFQKPGQIPHPEDEYTHDSVKIQLLDLLTRVKSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D2</accession>
    <name>K9Z8D2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein Cyan10605_3367</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221127.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3367"/>
    <dbReference type="EnsemblBacteria" id="AFZ55409">
        <property type="protein sequence ID" value="AFZ55409"/>
        <property type="gene ID" value="Cyan10605_3367"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3367"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3585"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_3_2_3"/>
    <dbReference type="OMA" id="VDFEISM"/>
    <dbReference type="OrthoDB" id="2015368at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="108" mass="11669" checksum="2FB6B88CC635CC27" modified="2013-03-06" version="1">MIVTTTDNIQNQEISSYLGVVTAEVIYGTNALRDFFAGIRDMFGGRTGSYEKVFEKAQLEAIEELKKRAIKLNADAVIGIKVDTGTINVDQEGVLLLVTATGTAVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F0</accession>
    <name>K9Z8F0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221189.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z8F0"/>
    <dbReference type="STRING" id="755178.Cyan10605_3431"/>
    <dbReference type="EnsemblBacteria" id="AFZ55471">
        <property type="protein sequence ID" value="AFZ55471"/>
        <property type="gene ID" value="Cyan10605_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3431"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3656"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_3"/>
    <dbReference type="OMA" id="PVEHKAV"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="5"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="388" mass="42637" checksum="86E450E8F932803D" modified="2013-03-06" version="1">MSNPIYLDYHSTTPVDRRVAQKVYDYMVHNFGNSSSIDHIFGDRTQEAIKKAKRQIADLINSSPQEIIFTSGTTESINLVIQGLQPSRIIISPVEHKAVIDTCQAMAKKGLAEIIWLKVDKKARIDFNHLEKVCSQGADLLCIMGANNEVGNIYPIEEIGKIAQKYHIPFLCDGSQAVGKIPVNFEDWGITFLTISGHKLYAPKGIGALVIRKGYRLQPLIYGGGHQNGIRSGTLNVSGIVGLGEACYLRQLEMQEDESAIALKRNHLQSLLQSKIPQLVVNGDTENRLAGNLHISIPNVPNSAIIARIRHQLAISTGSACSSATVSPSHVLRAMNLSDDLIEGALRIGVGKFTRDIEIEKSADIITNAVEKIFQLTSIYDADKFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G5</accession>
    <name>K9Z8G5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220597.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2808"/>
    <dbReference type="EnsemblBacteria" id="AFZ54875">
        <property type="protein sequence ID" value="AFZ54875"/>
        <property type="gene ID" value="Cyan10605_2808"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2808"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2985"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_3"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="343"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="774" mass="89295" checksum="906D436A6A9A41F3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H5</accession>
    <name>K9Z8H5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ordered locus">Cyan10605_2593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2593"/>
    <dbReference type="EnsemblBacteria" id="AFZ54668">
        <property type="protein sequence ID" value="AFZ54668"/>
        <property type="gene ID" value="Cyan10605_2593"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2593"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2754"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_3"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1009" mass="116296" checksum="92A193E8D5375C51" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L0</accession>
    <name>K9Z8L0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220652.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2864"/>
    <dbReference type="EnsemblBacteria" id="AFZ54930">
        <property type="protein sequence ID" value="AFZ54930"/>
        <property type="gene ID" value="Cyan10605_2864"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2864"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3044"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062814_1_1_3"/>
    <dbReference type="OMA" id="VTIPHNK"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="31726" checksum="6AC01440D2F49AD1" modified="2013-03-06" version="1">MFVSGYLLQLDASNSEKISRLIDNITLGKVIQGVLLVVLAYWGQIFVAKIINWLAEKVPLKYRLKVKQSLPFWRAFVLGIVGVSLINLFLNLSADNILPLTGTIAVALGFAFKDYASSVIAGVLALFENPYQVGDRVKIGDDYGEVISYGLRGIMLQTPDDNIVTIPHNKLWTESISNANKGNLEAQTVISFYFSHDVDIENVFYLLYRVAQTSKYTQLNLPILVVMEEKPWATYFKLKCYPIDARDEFIYQTDLVRRAKRYFQRDNLPYPILPPLDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M0</accession>
    <name>K9Z8M0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Cyanophycinase</fullName>
            <ecNumber evidence="4 8">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220662.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2874"/>
    <dbReference type="EnsemblBacteria" id="AFZ54940">
        <property type="protein sequence ID" value="AFZ54940"/>
        <property type="gene ID" value="Cyan10605_2874"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2874"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3054"/>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053928_0_0_3"/>
    <dbReference type="OMA" id="FMTGGDQ"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR032067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="29863" checksum="1B2DC91A46DCD890" modified="2013-03-06" version="1">MKQYQRSSILVIGGAEDKVHGKEILQSFWHCAGGTSAIIGIIPSASREPTIIGERYFNIFRDMGAKDIRVLDVRDRIHGEDKGYQEYVEECTGIFMTGGDQLRLCGLLADTPLMERIRQRVKLGEVTLAGTSAGAAVMGHHMIAGGSSGESPNRALVDMAMGLGIIPEVIVDQHFHNRNRMARLLSAISSHPERLGIGIDEDTCAVFHHHNEFIEVLGRGTVTIVDAQAMSYTNQGDVSAEAPLALHNLRLHILGHGDRYNIKNHQPIAAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S9</accession>
    <name>K9Z8S9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ordered locus">Cyan10605_3070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3070"/>
    <dbReference type="EnsemblBacteria" id="AFZ55127">
        <property type="protein sequence ID" value="AFZ55127"/>
        <property type="gene ID" value="Cyan10605_3070"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3070"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3273"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_3"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="416" mass="45650" checksum="FF9D6BE100765AC2" modified="2013-03-06" version="1">MTTATLETTKTGFSQDTFNQYVMNTYGRFPVAIEKGEGCKLWDTEDKEYLDFVAGIATCTLGHAHPALVEAVTKQIKKLHHISNLYYIPEQGELAKWIVDHSCADKVFFCNSGAEANEAAIKLVRKYAHTVLEFLEQPVILTAKSSFHGRTLATITATGQPKYQKNFEPLVPGFEYVPYNDITAIEEAITDIDEGDRRVAAIMIEPLQGEGGVRPGELEYFLRLRKICDDTGILLVFDEVQTGVGRTGKMWGYENLGIEPDIITSAKGLAGGIPIGAMMCKASCDVFEPGNHASTFGGNPFACASALAVLQTIEKDNLLQNVQARGEQLRTRLRAISQKYSDIFIDVRGWGLINGMEINNNAELTSIEVVKKAMENGLLLAPAGPKVIRFVPPLIVSAEEIDQGSDILEKTVSQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z7</accession>
    <name>K9Z8Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ordered locus">Cyan10605_2781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220570.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z8Z7"/>
    <dbReference type="STRING" id="755178.Cyan10605_2781"/>
    <dbReference type="EnsemblBacteria" id="AFZ54848">
        <property type="protein sequence ID" value="AFZ54848"/>
        <property type="gene ID" value="Cyan10605_2781"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2781"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2954"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_2_3"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17031" checksum="F07D5E6F117FCA79" modified="2013-03-06" version="1">MKKNPIFWIVAIIALIIDQITKYLVVISFPEIGDTMPLWQGVFHFTYVQNTGAAFSFFQGGVGWLKWLSLIVSLGLMIFAWKEKLSKIEQFAYGFILAGALGNGVDRFLFGYVVDFLDFRLINFPVFNMADVCINIGIVLLIYATIKMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z946</accession>
    <name>K9Z946_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ordered locus">Cyan10605_3073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220849.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3073"/>
    <dbReference type="EnsemblBacteria" id="AFZ55130">
        <property type="protein sequence ID" value="AFZ55130"/>
        <property type="gene ID" value="Cyan10605_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3073"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3276"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_3"/>
    <dbReference type="OMA" id="GFKRQDP"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="199" mass="22260" checksum="F121070C700FFC83" modified="2013-03-06" version="1">MPIGVPRVPYQLPGQPYSDWVNIYDRLYRERIIFLGRGVNDSLANQIIAVMLYLDSEDNSKPIYLYINSPGGSVTAGLAIYDTMQHIKSEVVTICVGLAASMGAFLLSAGTKGKRLALPHSRIMIHQPLGGIQGRRQATDIEIEAKEILRIKHDLNEMMALHTGQPIEKIEKDTDRDYFMSAAEAKEYGLIDKVIEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z959</accession>
    <name>K9Z959_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2862"/>
    <dbReference type="EnsemblBacteria" id="AFZ54928">
        <property type="protein sequence ID" value="AFZ54928"/>
        <property type="gene ID" value="Cyan10605_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2862"/>
    <dbReference type="eggNOG" id="ENOG5032Y73">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130851_1_0_3"/>
    <dbReference type="OMA" id="PAHELMG"/>
    <dbReference type="OrthoDB" id="1778256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13038" checksum="18C2AEB665FCAB5A" modified="2013-03-06" version="1">MSETLENKDKQPANKLTTPTATTTKESSALKLADKSAALLPGNRPVEANHLQIVHTYTSVGSIRPVTKSNLDIKSMMTLSGNRPIAASHLQISQEFKIMGNRPVASNHIDDPLLLMGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C1</accession>
    <name>K9Z9C1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55327">
        <property type="protein sequence ID" value="AFZ55327"/>
        <property type="gene ID" value="Cyan10605_3281"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3281"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3496"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="OMA" id="QLAINCY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10852" checksum="7004A340CBE7439A" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSQFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSIANGSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA11</accession>
    <name>K9ZA11_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221148.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3388"/>
    <dbReference type="EnsemblBacteria" id="AFZ55430">
        <property type="protein sequence ID" value="AFZ55430"/>
        <property type="gene ID" value="Cyan10605_3388"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3388"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013507_0_0_3"/>
    <dbReference type="OMA" id="DYGEDQF"/>
    <dbReference type="OrthoDB" id="447064at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="709" mass="79198" checksum="241A3CB61B2E02B6" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAG0</accession>
    <name>K9ZAG0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221295.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3547"/>
    <dbReference type="EnsemblBacteria" id="AFZ55580">
        <property type="protein sequence ID" value="AFZ55580"/>
        <property type="gene ID" value="Cyan10605_3547"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3547"/>
    <dbReference type="HOGENOM" id="CLU_2768900_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="8479" checksum="C58E013F5336B9C1" modified="2013-03-06" version="1">MEYLQWEAAVNKKLSKYFSQRILDKYNSSYEHLFNNNQTPQEAFDYLYEYINDSEDAQQPFWFDMIGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAG3</accession>
    <name>K9ZAG3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ordered locus">Cyan10605_3336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221096.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3336"/>
    <dbReference type="EnsemblBacteria" id="AFZ55378">
        <property type="protein sequence ID" value="AFZ55378"/>
        <property type="gene ID" value="Cyan10605_3336"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3336"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3552"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_1_3"/>
    <dbReference type="OMA" id="MVQAVRT"/>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24253" checksum="11DD214CF6D65356" modified="2013-03-06" version="1">MTYTESSIIKSANQNNSLPNLITESQPPVTEADMIQAVRTLLLGLGENPDREGLKDTPKRVVKALKFLTSGYGQSLDELLNGAVFHENANEMVLVRDIDLFSSCEHHILPILGRAHVAYIPNGKVIGLSKIARICEMYARRLQVQERLTAQIADALQGLLQPQGVAVVIEATHMCMVMRGVQKPGSWTSTSALRGVFNDDAKTRQEFMNLIQHRPTFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ67</accession>
    <name>K9YZ67_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0065"/>
    <dbReference type="EnsemblBacteria" id="AFZ52226">
        <property type="protein sequence ID" value="AFZ52226"/>
        <property type="gene ID" value="Cyan10605_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0065"/>
    <dbReference type="eggNOG" id="ENOG50316YV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163164_0_0_3"/>
    <dbReference type="OMA" id="IACEAES"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014947">
        <property type="entry name" value="DUF1818"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08848">
        <property type="entry name" value="DUF1818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="SSF54447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13465" checksum="37146AEAB7386133" modified="2013-03-06" version="1">MIKQGKGWRIGWKPNPCTYQGLLGGEDWAMELTSAEMADFCRLLPEINQAVIDISEHLMDEEKIVCEMESELLWLGAEGYPQNYSLRVILSQGRCCEGTWSVEVLPELLKAIQSFHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ71</accession>
    <name>K9YZ71_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIID/LytB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217963.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0070"/>
    <dbReference type="EnsemblBacteria" id="AFZ52231">
        <property type="protein sequence ID" value="AFZ52231"/>
        <property type="gene ID" value="Cyan10605_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0070"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.72"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036694_0_0_3"/>
    <dbReference type="OMA" id="DGYHLCS"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="232"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="540" mass="61152" checksum="8B8A91E767060F33" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ98</accession>
    <name>K9YZ98_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217993.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0102"/>
    <dbReference type="EnsemblBacteria" id="AFZ52261">
        <property type="protein sequence ID" value="AFZ52261"/>
        <property type="gene ID" value="Cyan10605_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0102"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701786_0_0_3"/>
    <dbReference type="OMA" id="EPGAIQF"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="42901" checksum="DEC63BB634754986" modified="2013-03-06" version="1">MNNYDVIIIGGGLTGSVLSYELAKKNLRVLLLEKDSIFNNATVYSYGGISYWCGTDETTIKLCQEGINIYRNLTEELDYNIDFRELDLLFTIDKNQDPENTFQQYQKFHIAPKLLDKKETNSLEPLINIDAISGSLRFPQGHVQPEKMIFAYQKALMRLGGKVEQELVISVEKNQDKIIGVKTEKNSYSASQIILCAGAFSRSILQNLGINLPLYFSHAQLIMTPPAPVKLKTLVMPCTMKRLDTEKQVAQSAEKIWQKESNTLYGDVLEAGAIQFLDGSFCLGQISQIIPNLNSPIDSVISEKRLRDAIASILPSLANLSGKWHNCQVAFTEGMPFLVGKIGQIEGLSIFSGFTSPFVFVPPLARYFADYLVNGEETLISFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZQ9</accession>
    <name>K9YZQ9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane adhesin like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218168.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0288"/>
    <dbReference type="EnsemblBacteria" id="AFZ52436">
        <property type="protein sequence ID" value="AFZ52436"/>
        <property type="gene ID" value="Cyan10605_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0288"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.298"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234844_0_0_3"/>
    <dbReference type="OMA" id="FAENERY"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="652"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1947" mass="211053" checksum="B8F5E8CCADD6C161" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZR6</accession>
    <name>K9YZR6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 4, conserved region-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218141.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0259"/>
    <dbReference type="EnsemblBacteria" id="AFZ52409">
        <property type="protein sequence ID" value="AFZ52409"/>
        <property type="gene ID" value="Cyan10605_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0259"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.269"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_2_3_3"/>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="356" mass="38618" checksum="3E065E7F6F3D121A" modified="2013-03-06" version="1">MLPKTSSVNEIYHLIAFLVSMNVVMWSTPVVKNIGLRSGHVDKPDARKIHSQPIVRIGGIAIFAGTTAGLLIVWWLGGFGVLSPEKDAEIWGVTIGAIFFFFIGLADDLFNLSPQSRLLVQSIVASFAWYKGVRIDFFTIPFGDLIQIDMWWLSLPITVIWLVGMVNAVNWIDGLDGLAAGVCGIAAVVMLIVSLFMNQPAAALLAAGLAGGALGFLRYNFNPAEIFMGDGGAYFMGFMLAGVAVIGISKTAAVTAVLLPYVILAVPILDMSWVILSRVLQGKSPFLPDKRHLHHRLLQAGISQRLTAIYIYSLTLWAGSLALAFSGFPSGGVYALGATMLLIYTTWQVWRNSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZZ4</accession>
    <name>K9YZZ4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218257.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0381"/>
    <dbReference type="EnsemblBacteria" id="AFZ52526">
        <property type="protein sequence ID" value="AFZ52526"/>
        <property type="gene ID" value="Cyan10605_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0381"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.402"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127724_0_0_3"/>
    <dbReference type="OMA" id="PYVIWAT"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21549" checksum="9EC7032AA0790B0D" modified="2013-03-06" version="1">MTESNQPNLNSFTRTQILGFMGITALILLIISQIWQRLGKINLIPVKFNLHDFSMGVLIAIAIILASSILTRVWEDYRHSAEKYLNLIISPLILADLIWVGLLPGLSEELLFRGVMLPAFGYDWLALILSSVFFGILHWSEVSSWHYVVWAIIIGFVLGYSAYITGNLLVPIVAHSLTNFVSSLLWKLKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z074</accession>
    <name>K9Z074_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218332.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0459"/>
    <dbReference type="EnsemblBacteria" id="AFZ52601">
        <property type="protein sequence ID" value="AFZ52601"/>
        <property type="gene ID" value="Cyan10605_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0459"/>
    <dbReference type="eggNOG" id="ENOG5032ZPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157044_2_0_3"/>
    <dbReference type="OMA" id="PTPLRCI"/>
    <dbReference type="OrthoDB" id="2006059at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021434">
        <property type="entry name" value="DUF3082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11282">
        <property type="entry name" value="DUF3082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="11887" checksum="A4B189D360F36EB2" modified="2013-03-06" version="1">MTDKEKKEPIIPSPEAEQEKITPLRCMTGSAISGGLAVAAYLLTKSVILTYVNMPIKFNNPLAANIASTVRTLIMGVTTMATFLFLMVAVGLFALGVKRFIEEKREPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z080</accession>
    <name>K9Z080_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0430"/>
    <dbReference type="EnsemblBacteria" id="AFZ52574">
        <property type="protein sequence ID" value="AFZ52574"/>
        <property type="gene ID" value="Cyan10605_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0430"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.453"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_3"/>
    <dbReference type="OMA" id="IYDINWR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="860" mass="98685" checksum="83E829F5F8EC76BD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V0</accession>
    <name>K9Z0V0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Cytochrome b559 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">PSII reaction center subunit V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psbE</name>
        <name evidence="18" type="ordered locus">Cyan10605_0690</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="13">With its partner (PsbF) binds heme. PSII binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha subunit and a beta subunit. Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha subunit and beta subunit. Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13 15">Cellular thylakoid membrane</location>
            <topology evidence="13 15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 15">Belongs to the PsbE/PsbF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218557.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0690"/>
    <dbReference type="EnsemblBacteria" id="AFZ52826">
        <property type="protein sequence ID" value="AFZ52826"/>
        <property type="gene ID" value="Cyan10605_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0690"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.724"/>
    <dbReference type="eggNOG" id="ENOG5032RR6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194095_0_0_3"/>
    <dbReference type="OMA" id="VRYWVIH"/>
    <dbReference type="OrthoDB" id="1863986at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00642">
        <property type="entry name" value="PSII_PsbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006217">
        <property type="entry name" value="PSII_cyt_b559_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037025">
        <property type="entry name" value="PSII_cyt_b559_asu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006216">
        <property type="entry name" value="PSII_cyt_b559_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013081">
        <property type="entry name" value="PSII_cyt_b559_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013082">
        <property type="entry name" value="PSII_cytb559_asu_lum"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00283">
        <property type="entry name" value="Cytochrom_B559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00284">
        <property type="entry name" value="Cytochrom_B559a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000036">
        <property type="entry name" value="PsbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01332">
        <property type="entry name" value="cyt_b559_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00537">
        <property type="entry name" value="CYTOCHROME_B559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 15" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="12 13 15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_B559" evidence="16">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_B559a" evidence="17">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with beta subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ52826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9390" checksum="3F682FC998CE9CFA" modified="2013-03-06" version="1">MAGTTGERPFSDIVTSVRYWVIHSITIPMLFIAGWLFVSTGLAYDVFGTPRPDEYFTQTRQELPIINDRYEAKNQIEQFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W5</accession>
    <name>K9Z0W5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ordered locus">Cyan10605_0223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218109.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0223"/>
    <dbReference type="EnsemblBacteria" id="AFZ52377">
        <property type="protein sequence ID" value="AFZ52377"/>
        <property type="gene ID" value="Cyan10605_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0223"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.232"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_3"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="186" mass="20982" checksum="884DAC64A95F9A20" modified="2013-03-06" version="1">MNLTTIEKEKLAIPPLQLHYLGDRTLRQNTKRINKIDDSVRELAKQMLQTMYTENGIGLAAPQIGVHKQMIVVDCQPDNPASQPMVLINPEITKFSKDLCVAEEGCLSIPNVFLEVIRPRNIQLTYKDESGKKHKIKASGLLSRVIQHEMDHLHGILFVDRVKNSIALGEELKKKGFSIEAVQPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X9</accession>
    <name>K9Z0X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218550.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0681"/>
    <dbReference type="EnsemblBacteria" id="AFZ52819">
        <property type="protein sequence ID" value="AFZ52819"/>
        <property type="gene ID" value="Cyan10605_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0681"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="OMA" id="RRWRIRE"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="108" mass="12878" checksum="F2307D76EBEB158A" modified="2013-03-06" version="1">MTTTLNRNFNVPLKKIAEFCHKWEIIEFAVFGSILRDDFSSDSDIDCLVKFSENSYWSLFDRVKMKEELALILNRKVDLVNRKSIENSENWLRKQEILKTNKVIYVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z171</accession>
    <name>K9Z171_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218042.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0153"/>
    <dbReference type="EnsemblBacteria" id="AFZ52310">
        <property type="protein sequence ID" value="AFZ52310"/>
        <property type="gene ID" value="Cyan10605_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0153"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.159"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_3_3"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="32261" checksum="32C1E44CC885E82A" modified="2013-03-06" version="1">MGRKALLLINRHSRKGEKSLPLAVEYFYAHDLELIIKPVKDAQELGIVVREYHHQIDFVIVGGGDGTLNAVVDSLVETNLPLGILPLGTANDLARTLNIPLAMREACNVIGNGKLKSIDLGWVNGKYFFNVASMGLSVDITKKLSRGVKRRWGVFAYAITALQVISTARRFSATIKVDNETLPVKTVQIAIGNGRYYGGGMAIANDAAIDDQRLDLYSIELQHWWQIFPLIWHLPKGEHHQLQWVRTIEGKEIEIHTYKSYSVNTDGEITTITPAKFKVIPHALKVFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z199</accession>
    <name>K9Z199_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218670.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0806"/>
    <dbReference type="EnsemblBacteria" id="AFZ52939">
        <property type="protein sequence ID" value="AFZ52939"/>
        <property type="gene ID" value="Cyan10605_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0806"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.848"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034159_0_0_3"/>
    <dbReference type="OMA" id="PQMGGCW"/>
    <dbReference type="OrthoDB" id="478217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041695">
        <property type="entry name" value="GST_C_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044629">
        <property type="entry name" value="GSTL1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44328">
        <property type="entry name" value="PTHR44328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16865">
        <property type="entry name" value="GST_C_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="400" mass="47140" checksum="79C3B65AF5AE9338" modified="2013-03-06" version="1">MLNPLSWQELEALTDFQIDKVNGVTNSQSTLRLFNKPEEKVRVTLYRDHHAWCPYCQKIWLWLEEKQIPYRIRKVTMFCYGQKESWYKEKVPSGMLPAVELDGHIITESDDILKALEQDFGVLGYGMEDEKVIPLRRLERLLFRAWCTWLCYPTMFPLQEMNNRRGFLQVVKEVEGALSVTDSPFFLDDFSVADVVFVPYVERMNASLYYYKGYSLREENPLLSRWFSALEERSTYRGTQSDFHTHAHDLPPQMGGCYSNNEKQTLINQKRVDRGDWFSLPDVKYNEPENSRQEALYRVLKHRHNIIKVNPTDNEMFDLALRCALTYMMTDKECSPPPETDLALRYLRDRICVPRDMSIYAAKRLRTALEYTASLAGDRQPEALPLRHRRDQNPMNFQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B8</accession>
    <name>K9Z1B8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxysome shell protein CcmK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Carbon dioxide-concentrating mechanism protein CcmK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmK</name>
        <name evidence="6" type="ordered locus">Cyan10605_0827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer. Interacts with CcmN and CcmO in the carboxysome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The tight homohexamer forms a small pore which is positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial microcompartments protein family. CcmK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218690.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0827"/>
    <dbReference type="EnsemblBacteria" id="AFZ52959">
        <property type="protein sequence ID" value="AFZ52959"/>
        <property type="gene ID" value="Cyan10605_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0827"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.870"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_0_3"/>
    <dbReference type="OMA" id="QFREGVN"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00854">
        <property type="entry name" value="CcmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046380">
        <property type="entry name" value="CcmK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="4" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="5">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12133" checksum="0FE2B09C202CB936" modified="2013-03-06" version="1">MSIAVGMVETLGFPAVVEAADAMVKAARVTLVGYEKIGTGRVTVIVRGDVSEVQASVAAGIENVKRVKGGQVLSHHIIARPHENLEYVLPIRYTEEVEQFRESVNPRPLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D8</accession>
    <name>K9Z1D8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ordered locus">Cyan10605_0847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218710.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0847"/>
    <dbReference type="EnsemblBacteria" id="AFZ52979">
        <property type="protein sequence ID" value="AFZ52979"/>
        <property type="gene ID" value="Cyan10605_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0847"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.890"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_3"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="217"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="34592" checksum="FB6180F6EE508F4E" modified="2013-03-06" version="1">MQSYSLFAPAKINLHLEIIGDRTDGYHELVMIMQSVNLGDIIHLRANGTDEIRLFCQNPQVPLDDTNLAYKAVRLVQEKYPTLSRNYGGIDITIEKNIPVAAGLAGGSSNAAAVLVGLNLMWNLGLTQPELKDLGALLGSDVPFCISGGTAIATGRGEQIEPLPDLKNLWVILAKYSNISVSTGWAYNTYRELFNHEYISNPQEVKQRTHEIHSGNLVKAISKNDYKQIGALLYNDLEKVVLPEYSAVNELIEAFKSKNVLGAMMSGSGPTVFALCDKKEEAETIMEEVKESINDPNLDCWLTQVCPHGIMVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H8</accession>
    <name>K9Z1H8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="5" type="ordered locus">Cyan10605_0032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217925.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0032"/>
    <dbReference type="EnsemblBacteria" id="AFZ52193">
        <property type="protein sequence ID" value="AFZ52193"/>
        <property type="gene ID" value="Cyan10605_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0032"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.34"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_1_3"/>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="20324" checksum="376D016AD092A3EE" modified="2013-03-06" version="1">MENNNSAWRQQLLNLLVEYAYQEGDFTLSSGQKSSFYLNGKQVTLRAEGALLVGKLIFSMLSDDTDAIAGLTLGADPMVSAVSVVSAYENKPIPALIIRKEAKGHGTKAYIEGPTLKQGALVTVLEDVVTTGKSAMLAVERLTDAGYKVNQVISLVDRLSGGRELYQSHGLSFASIFTIDEIQAHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V3</accession>
    <name>K9Z1V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218090.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0202"/>
    <dbReference type="EnsemblBacteria" id="AFZ52358">
        <property type="protein sequence ID" value="AFZ52358"/>
        <property type="gene ID" value="Cyan10605_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0202"/>
    <dbReference type="HOGENOM" id="CLU_2878350_0_0_3"/>
    <dbReference type="OMA" id="TWVYIQN"/>
    <dbReference type="OrthoDB" id="666223at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="63" mass="7729" checksum="DC3A703CD4E627D3" modified="2013-03-06" version="1">MNNYTWVYIQNHPQETKRLLGINYEQLQQLIDYLKFLEDNENKAQETKKKPSPHQKKTSKHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X7</accession>
    <name>K9Z1X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218895.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1038"/>
    <dbReference type="EnsemblBacteria" id="AFZ53164">
        <property type="protein sequence ID" value="AFZ53164"/>
        <property type="gene ID" value="Cyan10605_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1038"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009398_1_1_3"/>
    <dbReference type="OMA" id="HENLIAC"/>
    <dbReference type="OrthoDB" id="50133at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="224"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126974" checksum="C792820E8AE53E77" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z204</accession>
    <name>K9Z204_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218155.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0273"/>
    <dbReference type="EnsemblBacteria" id="AFZ52423">
        <property type="protein sequence ID" value="AFZ52423"/>
        <property type="gene ID" value="Cyan10605_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0273"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.283"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078216_0_0_3"/>
    <dbReference type="OMA" id="CTAIVRG"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="4">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="BMC" evidence="4">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30319" checksum="423157A18810F609" modified="2013-03-06" version="1" precursor="true">MRHRHISPDSALGLVSTYSFPAIVGTADMMLKSAEVMLVGYEKIGAGHCTAIVRGRIADVRLAVEEGAKMAEQIGQLHTKLIIPRPMPNLEAVFPIGSRLVEVAQQKRGFSRLSNRSIGLLETKGFPAMVGAADAMLKSADVQLASYETIGAGLCTVIVRGSVANVAVAIEAGMAEAERIGDLNAVMIIPRLLEDLEHTLPVANYWLEQENKEHPLPTFTSRQKERAKRKLVALPELEKIPLTFETREKVKQEAKLESQLELSSELELSPESDDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z208</accession>
    <name>K9Z208_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218952.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1099"/>
    <dbReference type="EnsemblBacteria" id="AFZ53221">
        <property type="protein sequence ID" value="AFZ53221"/>
        <property type="gene ID" value="Cyan10605_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1099"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107036_0_0_3"/>
    <dbReference type="OMA" id="HCLNYGT"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21951" checksum="8CCB0122B4CE4767" modified="2013-03-06" version="1">MVTLITNKTTNQTISLEEFLQLPETKPVREYFDNKITQKPMPQAKHSRIQGKLTKVINDVVEESKIALAFPELRCTFNDKSIVPDIVVLTYNHIPKDENGELTNTISIPPDWMIEILSPDQSQTLIIKKILRCLESGCQLAWIIDPEEKIIFVYSLQKVSYFELDSDVLPMPDFMADFSLTLGDIFGWLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z224</accession>
    <name>K9Z224_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0295"/>
    <dbReference type="EnsemblBacteria" id="AFZ52443">
        <property type="protein sequence ID" value="AFZ52443"/>
        <property type="gene ID" value="Cyan10605_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0295"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081798_2_0_3"/>
    <dbReference type="OrthoDB" id="1694484at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="20722" checksum="2B1996BD01372B38" modified="2013-03-06" version="1">MIIDLQWTLDQFLYKNVNESLSQIQESIILMKYYSFDLSGYQFRELIVKWTKIYPHNWLPLAVTEAIYQGRLKAISVEQILNVWQKKGKIQHSFNYEFVRLVKPDFSEEELNKYLEITGSFLSDLLSQENISRDYNCNDHDNNYIDANLTVNDFNPVEDFSHCFQKLRGFITNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z276</accession>
    <name>K9Z276_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218563.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52832">
        <property type="protein sequence ID" value="AFZ52832"/>
        <property type="gene ID" value="Cyan10605_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0696"/>
    <dbReference type="eggNOG" id="ENOG50346JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330100_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="206" mass="23873" checksum="C1A8DE615DB61FBF" modified="2013-03-06" version="1">MSYFKFHDLSKKTERLQKEISDSKTLWGENGEDEEKQLRQVKKKWLRQQNQEFQKLKHQESQNRSIKTLVSTLISIALIAIAFPFIPKLWQISVETVAEFLPKDSQTSGKPKKGGFLEKLKAMQDEYKQKEKIKQLVKACEKDPQKTPEECQTIAETSINNDVKPNNVNDSNDSNGKVIIEDQLLESLDNIDQYNKDLKKAIEMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z299</accession>
    <name>K9Z299_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218998.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1147"/>
    <dbReference type="EnsemblBacteria" id="AFZ53269">
        <property type="protein sequence ID" value="AFZ53269"/>
        <property type="gene ID" value="Cyan10605_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1147"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1214"/>
    <dbReference type="eggNOG" id="COG3019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112034_1_1_3"/>
    <dbReference type="OMA" id="GSCHTAF"/>
    <dbReference type="OrthoDB" id="1676023at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007332">
        <property type="entry name" value="DUF411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04214">
        <property type="entry name" value="DUF411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939070" evidence="1">
        <location>
            <begin position="33"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20470" checksum="7BD6193C614A9632" modified="2013-03-06" version="1" precursor="true">MTKARLIKKSTAMATMTIISSIAFSFNIPSYAHENHENHENKAITASVWDKSTVNYNGSKKITVYSSPSCGCCGQWISHMKKHGFEVTDIKTDDIEAIKRKNNLPPELASCHTAIINGYVMEGHIPANDIKRFLSQKPSNLKGLAVAGMPIGSPGMESDKIKQPFSVLSFNNKGNITVFNQYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B8</accession>
    <name>K9Z2B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218431.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0559"/>
    <dbReference type="EnsemblBacteria" id="AFZ52700">
        <property type="protein sequence ID" value="AFZ52700"/>
        <property type="gene ID" value="Cyan10605_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0559"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.590"/>
    <dbReference type="eggNOG" id="COG5493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081497_0_0_3"/>
    <dbReference type="OMA" id="WGDLANK"/>
    <dbReference type="OrthoDB" id="1511177at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="190" mass="21696" checksum="BB175F17A0483CDA" modified="2013-03-06" version="1">MTTTADDVWKILAELAESQKESDHRLQEIERILKEKSLETDRQITRLSKEIGNLGGKWGRFVENMVAPACETLFISRGIPVHQVSQRVKKKLDGRVLEIDILVTNQDHVLVVEVKSSLGVENVKELMEDLQEFREFFPEYSQKRVYGAVAGIEIEEGADKYAYRQGLFVLTQSGENVVIVNGDDFQPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D2</accession>
    <name>K9Z2D2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218623.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0759"/>
    <dbReference type="EnsemblBacteria" id="AFZ52892">
        <property type="protein sequence ID" value="AFZ52892"/>
        <property type="gene ID" value="Cyan10605_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0759"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.797"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423193_0_0_3"/>
    <dbReference type="OMA" id="THDECAN"/>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="147"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="650" mass="75232" checksum="3AC6B8F2B0602EF1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H4</accession>
    <name>K9Z2H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218663.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52932">
        <property type="protein sequence ID" value="AFZ52932"/>
        <property type="gene ID" value="Cyan10605_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0799"/>
    <dbReference type="eggNOG" id="ENOG5032WHP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1913586_0_0_3"/>
    <dbReference type="OMA" id="GPNSNTY"/>
    <dbReference type="OrthoDB" id="1857896at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022224">
        <property type="entry name" value="DUF3750"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12570">
        <property type="entry name" value="DUF3750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17531" checksum="9C3C120ABC7A9D44" modified="2013-03-06" version="1">MSYQVELRAAKIPYIGAIAVHYWFVIHEQVSERWEIWQTKSLVSSSWGHLHKNLMNPTRGVGNGGSWQEYVWQGEEADNLQTIIRKTPQIYPYNYLYRYYPGPNSNTYIQWILDKSQIRYSLGRKGLGKNYHRFFSKYEAIALLSTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q6</accession>
    <name>K9Z2Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219163.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1319"/>
    <dbReference type="EnsemblBacteria" id="AFZ53434">
        <property type="protein sequence ID" value="AFZ53434"/>
        <property type="gene ID" value="Cyan10605_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1319"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1392"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_15_4_3"/>
    <dbReference type="OMA" id="EHLFNGE"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="555" mass="64363" checksum="A93B6DA756C60185" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q9</accession>
    <name>K9Z2Q9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="10" type="ordered locus">Cyan10605_0725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218591.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0725"/>
    <dbReference type="EnsemblBacteria" id="AFZ52860">
        <property type="protein sequence ID" value="AFZ52860"/>
        <property type="gene ID" value="Cyan10605_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0725"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.760"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_1_0_3"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="OrthoDB" id="1150446at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="25154" checksum="C41AC5E503ABCEFB" modified="2013-03-06" version="1">MNKDKIIVPLDVPSLEDAIALVKKLPEVSFWKVGLELFVSTGSDILKYLKDENKKIFLDLKFHDIPNTVKSATKSALKYDVDLLTLHATAGREALTAAKEVVKESASPMKLLAISVLTSINSRQLALDLKIPLELPEYALNNALMARECGIDGAVCSPQEARKLKEVCGDDFILVCPGVRPEWAVTGDQQRVMTPKQAFAEGADYLVIGRPITQAENPVLAWEKVIAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U5</accession>
    <name>K9Z2U5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1420</name>
        <name evidence="3" type="ordered locus">Cyan10605_3143</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219260.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1420"/>
    <dbReference type="EnsemblBacteria" id="AFZ53531">
        <property type="protein sequence ID" value="AFZ53531"/>
        <property type="gene ID" value="Cyan10605_1420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55194">
        <property type="protein sequence ID" value="AFZ55194"/>
        <property type="gene ID" value="Cyan10605_3143"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1420"/>
    <dbReference type="KEGG" id="can:Cyan10605_3143"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1501"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101320_2_0_3"/>
    <dbReference type="OMA" id="YHLVWIP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="15379" checksum="599D283C32FBFF26" modified="2013-03-06" version="1">MEDYRRNPHSVTLLNYHFVWCPKRRKAVLKGKIVKRCQEIIFELCTENDWRLIALEIMPDHIHLFIETNPTYAPSVIIKRVKGRLSHHLRKEFPELLKLPTLWTPSYFCSTAGNASTETIKKYIENQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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    <name>K9Z2V8_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
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        <name evidence="2" type="ordered locus">Cyan10605_0542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0542"/>
    <dbReference type="EnsemblBacteria" id="AFZ52683">
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        <property type="gene ID" value="Cyan10605_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0542"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.573"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_3"/>
    <dbReference type="OMA" id="FIIPCFY"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
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        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
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        <location>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="571"/>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117451" checksum="FDABD762E089DD07" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="CASTNTI"/>
    <dbReference type="OrthoDB" id="2167985at2"/>
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    </dbReference>
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        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="536" mass="56644" checksum="8538BF24C2EDEBCB" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z341</accession>
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        <submittedName>
            <fullName evidence="6">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">Cyan10605_1463</name>
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    <organism evidence="6 7">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ53574">
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        <property type="gene ID" value="Cyan10605_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1463"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1551"/>
    <dbReference type="eggNOG" id="COG5135">
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    <dbReference type="OMA" id="ARLQFAW"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
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    </dbReference>
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        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
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        <property type="entry name" value="Pyridox_Oxase_FMN-dep_Alr4036"/>
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        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="23130" checksum="217CA001A5EAD3B9" modified="2013-03-06" version="1">MEITVKWRSHLQKALHKNRSQVFSKYIQLATITKEGYPANRTVVFRGFLENSNVIQIITDTRSEKYSHLQTNPVAEICWYFAKTREQFRIRGKIDLVIGNNNNLTWQKARQNTWNNLSKNGKEQFYWDTPGEEKIEKEKEEQIPIIDEKNPPENFCLLLLNPDKVDHLELRGNPQNRHLYTLQDNNQWSYTVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A0</accession>
    <name>K9Z3A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0940</name>
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    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0940"/>
    <dbReference type="EnsemblBacteria" id="AFZ53070">
        <property type="protein sequence ID" value="AFZ53070"/>
        <property type="gene ID" value="Cyan10605_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0940"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.991"/>
    <dbReference type="eggNOG" id="ENOG5032ZB7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200471_0_0_3"/>
    <dbReference type="OMA" id="EQPNLGT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="56" mass="6375" checksum="312EEBC3AA9B2C3A" modified="2013-03-06" version="1">MTTPIIAEKIRAIASKKEVLEQLLEKPDLGNLRLDVNQALEELEELIEELNKTFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C0</accession>
    <name>K9Z3C0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ordered locus">Cyan10605_0960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218821.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0960"/>
    <dbReference type="EnsemblBacteria" id="AFZ53090">
        <property type="protein sequence ID" value="AFZ53090"/>
        <property type="gene ID" value="Cyan10605_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0960"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1013"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_1_3"/>
    <dbReference type="OMA" id="MPEMIIV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="6417" checksum="3F7EBB9C42EAD207" modified="2013-03-06" version="1">MFGLGWAEVIIILIVAVLIFGPKKIPELGSSLGKTLRGFKDEVIRDDDNDNNDKESDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I7</accession>
    <name>K9Z3I7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin (Vitamin B12) biosynthesis CbiM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219031.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1181"/>
    <dbReference type="EnsemblBacteria" id="AFZ53302">
        <property type="protein sequence ID" value="AFZ53302"/>
        <property type="gene ID" value="Cyan10605_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1181"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1247"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_1_0_3"/>
    <dbReference type="OMA" id="MNMAVPA"/>
    <dbReference type="OrthoDB" id="1632785at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="23665" checksum="FDDDA0CA291FE36A" modified="2013-03-06" version="1">MHIPDGLLPPAVSISGYAITGGVTWFSLKQIHKQTNYQEEIPKASLLTAAFFVASLIHIPIPPFSIHLVLNGVMGLVLGYYAFPGILIGLFFQGMFFQHGGLSTLGINAIIMGVPALLAHYIWSFRTTSFFNTPFGKSTLAFLGGGLSVFLSALIFVFITINNIAPDLDIDAEKTAIFTSLIGYAVQALIEGILTVMLISFLEKVKPELIGLENSEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N5</accession>
    <name>K9Z3N5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219543.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53816">
        <property type="protein sequence ID" value="AFZ53816"/>
        <property type="gene ID" value="Cyan10605_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1713"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1820"/>
    <dbReference type="eggNOG" id="ENOG502ZBZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560322_0_0_3"/>
    <dbReference type="OMA" id="QYMVIWA"/>
    <dbReference type="OrthoDB" id="1458394at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="18641" checksum="CA0EEBC83AF8D82E" modified="2013-03-06" version="1" precursor="true">MSKLRNVLIGAGIAAVGAVGVKKAVDYFQNKKQQEALPETPEDAQISNPEEEVAFAVVETSSVQDFLDKSFGKSGRYNPNRPPKVFEYQDKQYMVIWAYDNEKSKNQMLVFQYTDSGRQMIASVGYTDSATDYNLKMGNTPFAVEINGAKLQSGEGETEGTSDVDFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R0</accession>
    <name>K9Z3R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219496.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1663"/>
    <dbReference type="EnsemblBacteria" id="AFZ53769">
        <property type="protein sequence ID" value="AFZ53769"/>
        <property type="gene ID" value="Cyan10605_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1663"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1765"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_3"/>
    <dbReference type="OMA" id="EGLKCYY"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="140" mass="15676" checksum="BD4A0B2F6376A0E0" modified="2013-03-06" version="1">MINKSYSQVEEKNNTQSLSDCLMAQMPPAALDLVADFFKVLSETSRLNIVCCLRTGSKNVTEIIDKTGLGQANVSKHLKILAQAGIVARTQKGINVYYQISNPFVFDLCDLVCNSLSIQIQQQHEQLRQIQKMQNNETVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S9</accession>
    <name>K9Z3S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1287"/>
    <dbReference type="EnsemblBacteria" id="AFZ53402">
        <property type="protein sequence ID" value="AFZ53402"/>
        <property type="gene ID" value="Cyan10605_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1287"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1360"/>
    <dbReference type="eggNOG" id="ENOG502Z8A8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983293_0_0_3"/>
    <dbReference type="OMA" id="FHFDHIF"/>
    <dbReference type="OrthoDB" id="803323at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939077" evidence="1">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="30461" checksum="0FDE739AB198D3AE" modified="2013-03-06" version="1" precursor="true">MKTLIIVKNWFNFSFVSFIAILFLSSCGNNSSNTTVSENEDYAGETLTLVANGEDFIRQGFTSKDGWRIDFNHAYVTLDEVIAYQTDPPFNAESDEMINASESIILVDEAITIDLAQGDENASPIIVAEAIAPTGVYNAISWKLINDAQSNSSIVLDGIAVKDGETINFVLNLPIPLEYQCGEFVGDERKGVLEAGKDAQLETTFHFDHIFGDGEATPEDEINVGAIGFQPLAQLSNNGELNIDLATMKAQLSPEDYEKLEKNLQSLGHVGEGHCRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T9</accession>
    <name>K9Z3T9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219141.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1297"/>
    <dbReference type="EnsemblBacteria" id="AFZ53412">
        <property type="protein sequence ID" value="AFZ53412"/>
        <property type="gene ID" value="Cyan10605_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1297"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1370"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078469_2_1_3"/>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="OrthoDB" id="1288973at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014075">
        <property type="entry name" value="SUF_FeS_clus_asmb_SufR_cyano"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02702">
        <property type="entry name" value="SufR_cyano"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="24688" checksum="4CF86CB3EBCF5047" modified="2013-03-06" version="1">MNTSLQSSSKEAILQYLLKENQASAQNIAEAMNISTQATRRHLKDLLEQGLIEYDLIRVKTGRPQYLYSLSRQGRDRFPQNYGEFAVSFLDTLTETVGENEVSRVLQKQWEKKADNYRKFMTGKSLQEKVTRLVEMRKEEGYMAELFIIEENPPQFFISEHNCAISDVAESYPQVCSHELEMFSSLFPECLVERTNWIHQGEHRCGYLIKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U2</accession>
    <name>K9Z3U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219598.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1769"/>
    <dbReference type="EnsemblBacteria" id="AFZ53871">
        <property type="protein sequence ID" value="AFZ53871"/>
        <property type="gene ID" value="Cyan10605_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1769"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1877"/>
    <dbReference type="eggNOG" id="ENOG5032ZJA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191962_0_0_3"/>
    <dbReference type="OMA" id="EDVQYHL"/>
    <dbReference type="OrthoDB" id="1980755at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7143" checksum="9EB372E98CE593C6" modified="2013-03-06" version="1">MNSTKEKVQSMLRKLPDDCTIEDIQYHLYVLGKIRQGLQIADTQGVLQQAEVEGLLNKWLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A6</accession>
    <name>K9Z4A6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219751.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1930"/>
    <dbReference type="REBASE" id="58404">
        <property type="entry name" value="Cap10605ORF1930P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54026">
        <property type="protein sequence ID" value="AFZ54026"/>
        <property type="gene ID" value="Cyan10605_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1930"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2051"/>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002539_0_0_3"/>
    <dbReference type="OMA" id="HEFFLFD"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025931">
        <property type="entry name" value="TaqI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12950">
        <property type="entry name" value="TaqI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eco57I" evidence="9">
        <location>
            <begin position="881"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="TaqI_C" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="797"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1320" mass="154245" checksum="5E6051B5BB911BB8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F5</accession>
    <name>K9Z4F5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ordered locus">Cyan10605_1512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219349.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1512"/>
    <dbReference type="EnsemblBacteria" id="AFZ53622">
        <property type="protein sequence ID" value="AFZ53622"/>
        <property type="gene ID" value="Cyan10605_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1512"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1605"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_3"/>
    <dbReference type="OMA" id="IHCAGRV"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="317" mass="35484" checksum="B46C3DCFCF7CA2B5" modified="2013-03-06" version="1">MLDLSTKKILVTGGAGFLGKQVVAELINAGANPDKITVPRSRDCDLTVWENCQKVVANQDIVIHLAAHVGGIGLNREKPAELFYDNLMMGAQLIHAAYQAGVEKFTCVGTICAYPKFTPVPFKEEDIWNGYPEETNAPYGIAKKALLVQLEAYRNQYGFNGIYLLPVNLYGPEDNFDPRSSHVIPALIRKVHEAQKRGDRTLPVWGDGSPTREFLYSNDAARGIVMGTQMYDSSEPINLGTNFEISIKDLTELICELMEFDGELIWETDKPNGQPRRCLDTTKAKETFGFTAKMNLREGLKRTIEWYRQNDSLTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F6</accession>
    <name>K9Z4F6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219199.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1356"/>
    <dbReference type="EnsemblBacteria" id="AFZ53470">
        <property type="protein sequence ID" value="AFZ53470"/>
        <property type="gene ID" value="Cyan10605_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1356"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1430"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_68_3"/>
    <dbReference type="OMA" id="WISNITA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="HisK_dim/P"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="41"/>
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        <location>
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        <location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="732" mass="83919" checksum="3FAD2244AE6CEB45" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54091">
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        <property type="gene ID" value="Cyan10605_1997"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_163218_0_0_3"/>
    <dbReference type="OMA" id="WQGETRE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="16263" checksum="5C66A4D28BC39D67" modified="2013-03-06" version="1">MMLSTSTVEDFFQRANWQGLKQIPVFDEEVTSEVFTGEESLKPELNFTVEKFFALNNWSGKTQVFTKPISAEEELELSEQGTYKPVYSLKMTVAEFFQRMVWQGQGKKRQLNIASIPAMDQTLISEPEKRQINVKDLSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L2</accession>
    <name>K9Z4L2_CYAAP</name>
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        <submittedName>
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        <name evidence="10" type="ordered locus">Cyan10605_2030</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ54121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2030"/>
    <dbReference type="EnsemblBacteria" id="AFZ54121">
        <property type="protein sequence ID" value="AFZ54121"/>
        <property type="gene ID" value="Cyan10605_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2030"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2157"/>
    <dbReference type="eggNOG" id="COG4771">
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    </dbReference>
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    <dbReference type="OMA" id="SDRLDVM"/>
    <dbReference type="OrthoDB" id="169533at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
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        <property type="entry name" value="BtuB-like"/>
    </dbReference>
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        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR30069"/>
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    </dbReference>
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        <property type="entry name" value="AMIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <feature type="domain" description="AMIN" evidence="9">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="192"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="851" mass="94364" checksum="F35612516F11AAB4" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N1</accession>
    <name>K9Z4N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219866.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2052"/>
    <dbReference type="EnsemblBacteria" id="AFZ54141">
        <property type="protein sequence ID" value="AFZ54141"/>
        <property type="gene ID" value="Cyan10605_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2052"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2180"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="KLKCGFR"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="39761" checksum="E89E03A37BF09E72" modified="2013-03-06" version="1">MAKIITSNDWEEIWAESHDNGTYISYSRNKYGYIIQGKHPYLGRNRCYGIDLRNGLSIEYNEVEFSDDLVILRDKLNQPLFGLSFFLSGKVRIERHGLTGKSEESIGRYYSDCNCDVKETEWWTKGEKFSRIYIEIEPQKFFNSFSQEDLSQIPPFLRQTLVEKQTQPYYDQGNITREMQKILRQILNCPYQGFMKQIYLESKSVELIALHCQQFQQNQLQDCRLQTGNLSDIDRIYQAKEILLKNLENPPTLMELSRRVGLNDFKLKRGFRELFGTSTFKYLHDYRLEQAKQLLTSGEMKVEDVALKVGFNSRSYFASAFRQKYGVNPKQFQKIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P8</accession>
    <name>K9Z4P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219881.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2067"/>
    <dbReference type="EnsemblBacteria" id="AFZ54156">
        <property type="protein sequence ID" value="AFZ54156"/>
        <property type="gene ID" value="Cyan10605_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2067"/>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075662_2_0_3"/>
    <dbReference type="OMA" id="IGTDCPG"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="23796" checksum="D10E320249B71539" modified="2013-03-06" version="1">MKKKLIIFTRYPEIGKTKTRLIPAIGAEKACFFHKSMTEMTVKKTDKLKEIVDVDVSVYFAGGNQTLMKAWLGNNYNYYPQNGDNLGEKMYSAFADSFKNNFSHVVLIGTDCIDLDENILNDTFNQLNFYDLVIGKAEDGGYYLIALKQLKKELFTNIKWGTDSVFETTVETASQLKYSIYQLPTLRDIDRPEDLQYLESKIISEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q9</accession>
    <name>K9Z4Q9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein Cyan10605_1589</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219424.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1589"/>
    <dbReference type="EnsemblBacteria" id="AFZ53697">
        <property type="protein sequence ID" value="AFZ53697"/>
        <property type="gene ID" value="Cyan10605_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1589"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1688"/>
    <dbReference type="eggNOG" id="COG1742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117653_2_0_3"/>
    <dbReference type="OMA" id="WLWAVEG"/>
    <dbReference type="OrthoDB" id="1991345at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12092" checksum="9455F3DB1E702DA0" modified="2013-03-06" version="1">MNIVKSLLFFLITGLAEIGGGYLVWLWLREGKSFKYAIVGWLILMLYGVLPTFQPTNFGRVYSAYGGAFVFFSLLWGWKIDKIPPDAYDWLGVVIILLGASIMMYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R0</accession>
    <name>K9Z4R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1459"/>
    <dbReference type="EnsemblBacteria" id="AFZ53570">
        <property type="protein sequence ID" value="AFZ53570"/>
        <property type="gene ID" value="Cyan10605_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1459"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1547"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="OMA" id="QIRFLYY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10855" checksum="F32DA7009E06B38B" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSLFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U8</accession>
    <name>K9Z4U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular exopolysaccharide family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219479.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1646"/>
    <dbReference type="EnsemblBacteria" id="AFZ53752">
        <property type="protein sequence ID" value="AFZ53752"/>
        <property type="gene ID" value="Cyan10605_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1646"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_2_2_3"/>
    <dbReference type="OMA" id="QQIYIQL"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="8">
        <location>
            <begin position="594"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="757" mass="85513" checksum="B070058D1D5D5116" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W4</accession>
    <name>K9Z4W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_1672</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219504.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1672"/>
    <dbReference type="EnsemblBacteria" id="AFZ53777">
        <property type="protein sequence ID" value="AFZ53777"/>
        <property type="gene ID" value="Cyan10605_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1672"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1775"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_3"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="12">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="822" mass="91539" checksum="600F6B48B26369B2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z515</accession>
    <name>K9Z515_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219392.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1556"/>
    <dbReference type="EnsemblBacteria" id="AFZ53665">
        <property type="protein sequence ID" value="AFZ53665"/>
        <property type="gene ID" value="Cyan10605_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1556"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1652"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_3"/>
    <dbReference type="OMA" id="LAGHGNF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="16"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="441"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="833" mass="93344" checksum="740D6D5ADC8EF27F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z516</accession>
    <name>K9Z516_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobaltochelatase CobN subunit</fullName>
            <ecNumber evidence="2">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219991.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2180"/>
    <dbReference type="EnsemblBacteria" id="AFZ54266">
        <property type="protein sequence ID" value="AFZ54266"/>
        <property type="gene ID" value="Cyan10605_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2180"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2316"/>
    <dbReference type="eggNOG" id="COG1429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002017_1_0_3"/>
    <dbReference type="OMA" id="YQFQGGL"/>
    <dbReference type="OrthoDB" id="8025at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1088" mass="124030" checksum="FF1119D4B8C72B77" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H2</accession>
    <name>K9Z5H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219537.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1707"/>
    <dbReference type="EnsemblBacteria" id="AFZ53810">
        <property type="protein sequence ID" value="AFZ53810"/>
        <property type="gene ID" value="Cyan10605_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1707"/>
    <dbReference type="eggNOG" id="ENOG5032SHT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134386_0_0_3"/>
    <dbReference type="OMA" id="FVAPEME"/>
    <dbReference type="OrthoDB" id="1675191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="19902" checksum="E18DA0D5D1D0BA67" modified="2013-03-06" version="1">MAKKQSKAFKDLQNLKPIEKKQKIKISRKKSSSLDNFAHDIKENHPDLVMRKVKKGELKMSEVIWNFVAPEMEIVSDLEEGHRLVSVAILAWNLSLLPEQERKDNINNYLVDLGIDNDPLESQAFKKFVQGFIDRKLKYFADIDRVIFDFKLEERRDTFHLSIASQLNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H4</accession>
    <name>K9Z5H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2310"/>
    <dbReference type="EnsemblBacteria" id="AFZ54394">
        <property type="protein sequence ID" value="AFZ54394"/>
        <property type="gene ID" value="Cyan10605_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2310"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2454"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406689_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="21255" checksum="4C5A6EE7CF1EEA39" modified="2013-03-06" version="1">MSKKQLQHIEEADKARRLKKHKELFNLLSIAAGLIFLQGYMIAPLIPRLSEVFNVPVQEIGFIVPAYMLSYALMALFYGLLSDRFGRWSIIRLSLIIFVVCTALIATSQTASQMATWRLLTGIGASGVIPLTFALIGDLFPFDQRGVKLGLVFAAMEGGMAAGSAGGAILEPYIGWRWLFLGTAIKEFLIIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S2</accession>
    <name>K9Z5S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219450.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1616"/>
    <dbReference type="EnsemblBacteria" id="AFZ53723">
        <property type="protein sequence ID" value="AFZ53723"/>
        <property type="gene ID" value="Cyan10605_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1616"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1716"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_3"/>
    <dbReference type="OMA" id="ADSFPWF"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="24811" checksum="966A168A24D0B75E" modified="2013-03-06" version="1">MALKVLIFDFDGTIADSRITLVKIANELADEFGYDPVTESDIVRLSNLSSKDVIIQSPIPAYKIPFLLRRVKRQLNEHIAYLQPFEGMKEALSNLKKKGCYLGIITSNLGANVSLFLRKNSLDNYFDFVYSANTLFGKNKVINKAIDKHRLLKDEVIYIGDETRDIEAAKKSNIKVAAVTWGFNSASVLKKYNPDFILDKPQELLDIIECNCGLNKSLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S5</accession>
    <name>K9Z5S5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2460"/>
    <dbReference type="REBASE" id="58398">
        <property type="entry name" value="M.Cap10605ORF2460P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54541">
        <property type="protein sequence ID" value="AFZ54541"/>
        <property type="gene ID" value="Cyan10605_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2460"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2605"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_4_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="412" mass="46856" checksum="C60A16AE4119CA83" modified="2013-03-06" version="1">MKRPTVIDLFSGCGGMSLGLEASGFDVAVAVEFDAIHALIHHLNFPYTHTICQDINHLNTDYLKGILQAKGIDEVDLIAGGPPCQGFSLMGKRQLDDPRNSLVFQYVRVIRDLQPKYFVFENVPGIAVGSHKQFLEELINEFESLGYHIAKPIKILDASLFGAPQKRKRLILMGSRHDMQPVNYPLETKEYNDVENTINDLSNIPAFIGKNESIDANKLDYSGFRRNFALKPQGIYGLCHDRQRDNLVYNHVGSNHTEKSKQRFQNTPQGEVEKTSRFLKLSPTGLCNTLRAGTARDKGAYTAARPIHYNQPRCITVREAGRLHTFPDWFLFHETIWHGFREIGNAVIPMLAKGIGDEIIKVLEVDINQLEVRKLEKIDLEFMAYNMDKASNYWNVSNDIIPKRKRLEMNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V8</accession>
    <name>K9Z5V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219490.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1657"/>
    <dbReference type="EnsemblBacteria" id="AFZ53763">
        <property type="protein sequence ID" value="AFZ53763"/>
        <property type="gene ID" value="Cyan10605_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1657"/>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130333_1_0_3"/>
    <dbReference type="OMA" id="MDFKTYQ"/>
    <dbReference type="OrthoDB" id="1760741at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11541">
        <property type="entry name" value="NTP-PPase_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011379">
        <property type="entry name" value="MazG-related_GP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006639">
        <property type="entry name" value="UCP006639_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12205" checksum="13207B8777E7212F" modified="2013-03-06" version="1">MNLNEYTLKTRETAIYPPETFLEYLTLGLASEAGEVSGVVKKYIRKDQNLDVAKEKLEKELGDVMWYWARLCDELGLDPQQVIENNIKKLQARKVNQTLQGDGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W5</accession>
    <name>K9Z5W5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1864"/>
    <dbReference type="EnsemblBacteria" id="AFZ53965">
        <property type="protein sequence ID" value="AFZ53965"/>
        <property type="gene ID" value="Cyan10605_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1864"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1977"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118536_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="19739" checksum="A65367B8F9E1B434" modified="2013-03-06" version="1">MGIAHLTKLNVGEPKIMCKLSIELVPQTCWFSNVRDHVDKKTWDLLRKDTYKKANYKCEICGGIGEKHPVECHEIWHYDDEKYIQTLMGLTALCPSCHQVKHIGLARVRGKEAEAKKHLAKVNNWSTLQVENYLAKVWSQWTQRSQFNWKLDLSWLEENFNIKVTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z607</accession>
    <name>K9Z607_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219550.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1720"/>
    <dbReference type="EnsemblBacteria" id="AFZ53823">
        <property type="protein sequence ID" value="AFZ53823"/>
        <property type="gene ID" value="Cyan10605_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1720"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757953_0_0_3"/>
    <dbReference type="OMA" id="DIDWMMA"/>
    <dbReference type="OrthoDB" id="1604212at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023892">
        <property type="entry name" value="cNMP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03896">
        <property type="entry name" value="cyc_nuc_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="169"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="41713" checksum="A1B1B7146936D4AB" modified="2013-03-06" version="1">MTDVLLQELSNSDIEWLKNTGQTQRVAVNTLLIEQTKQVDFVYIIIQGEFIATLTRHEKGRLGEVFAALEDNQSLEQEIGKFSEGEILGEMSFLEVNPAANSIRAIADSVVLSIPRESLNQKLQQDYGFAARFYRGMTILLLERFQHLITLYLKKRLGQIAPLQEVSLIFGELRDSDVDWFLQKGKLETFPANTVLIQSGEQVENIYILLQGVMNVSVSEQKKNRLNSIFALLESDDNTSSAPVEREIGHISRGEIVGEIAVLESHRSYCTIKTLENCSVLVISRQQMILKLQQDVGMASRFYRVIAKLMSGRVQGMISRLGFGKTSYSQGETLSQDTTYEDEIDLDVMDNLTLGGARFDWMLRRLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z630</accession>
    <name>K9Z630_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219902.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2088"/>
    <dbReference type="EnsemblBacteria" id="AFZ54177">
        <property type="protein sequence ID" value="AFZ54177"/>
        <property type="gene ID" value="Cyan10605_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2088"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2219"/>
    <dbReference type="eggNOG" id="COG1142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037469_0_0_3"/>
    <dbReference type="OMA" id="HWFKLIC"/>
    <dbReference type="OrthoDB" id="1263281at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021039">
        <property type="entry name" value="Fe-S-bd_prot_LdpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12617">
        <property type="entry name" value="LdpA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="38684" checksum="74C089477428849F" modified="2013-03-06" version="1">MSYSPFYSLQEGNWFKLICGASYQHLPSIRNLALIYTLAGADCIDMAADRAVIHSALEGIKKAQDLFVEAKNQGYDSHFSPFVMVSINDGEDPHFRKAYFNPNLCPIDCPRPCESICPADAITFSSMYRGVKSDLCYGCGRCLPICPLNLIQTESIFITIDTIVEWLDILPIDAIEIHTQEGHFSQFISVWKKLQPHLSKLKIIAISCPYTSNIMDYLQKISDFISPLEIPLIWQTDGRPMSGDIGEGTTHLTIKYAQKLMNSNLKGFIQLAGGTNEYTIKKLSELNLTSKVAGIAFGSKGRKIIADVLQELENISTTNQIENYPDLLWKGVEIASSLVSPLKLASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z651</accession>
    <name>K9Z651_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="9">FNR</shortName>
            <ecNumber evidence="6 9">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_2591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="6 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220389.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2591"/>
    <dbReference type="EnsemblBacteria" id="AFZ54666">
        <property type="protein sequence ID" value="AFZ54666"/>
        <property type="gene ID" value="Cyan10605_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2591"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2752"/>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053066_0_0_3"/>
    <dbReference type="OMA" id="GKAWLFM"/>
    <dbReference type="OrthoDB" id="707164at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008213">
        <property type="entry name" value="CpcD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015701">
        <property type="entry name" value="FNR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035442">
        <property type="entry name" value="FNR_plant_Cyanobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43314">
        <property type="entry name" value="PTHR43314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01383">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FNR-PetH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Frd-NADP+_RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01094">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51441">
        <property type="entry name" value="CPCD_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0521">NADP</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CpcD-like" evidence="14">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="120"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="402" mass="45570" checksum="73F14C562DB6D448" modified="2013-03-06" version="1">MRTFNNIKTFASSVNENRRFLFEVVGVSQQESNTLDYPIRKSGSVFIAVPYARMNQEMNRINRLGGKIINITPIDGLTPVQSPSQGSSTTTETQPMTQSEPKAKKEKKEVKVPVNIYRPKNPYVGKCLENYELVAEGGSGTVRHLTFDLSAGDLHYLEGQSIGIIPPGEDDNGKPHKLRLYSIASTRHGDNRDDKTVSLCVRQLEYQNDEGETVYGVCSSYLCNLEVGADVAITGPVGKEMLLPDDEDATIIMLATGTGIAPFRAFLWRMFKERELNPDYQFKGLAWLIFGIPYTQNILYKDDLEKMAADYSENFRLTYAISREQQTADGGKMYVQSRVSEYADELFELIQKPNTHVYMCGLKGMEPPISETFTAEAEKRGMNWDDLRKQMKKEERWHVEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z670</accession>
    <name>K9Z670_CYAAP</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54222">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="EIDFWLV"/>
    <dbReference type="OrthoDB" id="1793243at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019616">
        <property type="entry name" value="Ycf54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038409">
        <property type="entry name" value="Ycf54-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35319">
        <property type="entry name" value="PTHR35319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10674">
        <property type="entry name" value="Ycf54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12693" checksum="35501B92DE927872" modified="2013-03-06" version="1">MTTYYYLVASEKFLTSDNENLHEVLEEKERDYKEKNKEKDFWFIKQPAFLDAPEFKEIKAKCPQPAAAILSLNEQWITFLKLRLEYVITGKFDAPSADIPEPLASLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z673</accession>
    <name>K9Z673_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54644">
        <property type="protein sequence ID" value="AFZ54644"/>
        <property type="gene ID" value="Cyan10605_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2564"/>
    <dbReference type="eggNOG" id="ENOG5032Z7T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2356558_0_0_3"/>
    <dbReference type="OMA" id="TVICLDF"/>
    <dbReference type="OrthoDB" id="1829011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11617" checksum="B3BB7BE05C8C4EFA" modified="2013-03-06" version="1">MSESQSFFKSTSYDFEQEVLTRFRVLVEILPNECEIHRETWDSRTVICLDFQNCPYSLEIVKENVSILLNVMERFGLAKSIIFRDGNHLKAWRNLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I7</accession>
    <name>K9Z6I7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220462.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2665"/>
    <dbReference type="EnsemblBacteria" id="AFZ54739">
        <property type="protein sequence ID" value="AFZ54739"/>
        <property type="gene ID" value="Cyan10605_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2665"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2830"/>
    <dbReference type="eggNOG" id="ENOG502ZAE0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014939_0_0_3"/>
    <dbReference type="OMA" id="NIATYPF"/>
    <dbReference type="OrthoDB" id="1222825at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="30902" checksum="82ACAAD4FD2037DA" modified="2013-03-06" version="1">MYCLKISIAPTSAMTFRILPSSILNIATYPFVPPTTLSGYLRRLVMLSMKLEIPETDINKNNPPVYALPRKYITLGAYPVRDNFTAIHRTYRKGMREFNHDVFSRLYIEKEKADFQLHTWEYLITSELIGYVVTKSAEDLKPLQEIKGFGCKLGKEGFAVIQDISQPIKLTQITKEAIPSTIVPMEALLATNQFVNGCDIYNLYRYNWLTNQDNLNDNSPTAVNGFIPFVASYFQNQLTPELDYLTDSNNQINIPLSLINLLQLKGEITNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N5</accession>
    <name>K9Z6N5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b6-f complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome b6-f complex subunit PetG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Cytochrome b6-f complex subunit V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">petG</name>
        <name evidence="9" type="ordered locus">Cyan10605_2328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PetG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220136.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2328"/>
    <dbReference type="EnsemblBacteria" id="AFZ54412">
        <property type="protein sequence ID" value="AFZ54412"/>
        <property type="gene ID" value="Cyan10605_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2328"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2472"/>
    <dbReference type="eggNOG" id="ENOG5033BE9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_216962_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009512">
        <property type="term" value="C:cytochrome b6f complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00432">
        <property type="entry name" value="Cytb6_f_PetG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003683">
        <property type="entry name" value="Cyt_6/f_cplx_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036099">
        <property type="entry name" value="Cyt_6/f_cplx_su5_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02529">
        <property type="entry name" value="PetG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000034">
        <property type="entry name" value="Cyt_b6-f_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103446">
        <property type="entry name" value="SSF103446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="38" mass="4249" checksum="EE47677E2F4B89A0" modified="2013-03-06" version="1">MVEPLLLGIVLGLIPVTLIGLFFAAYRQYRRSSEIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T2</accession>
    <name>K9Z6T2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 6">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220176.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2369"/>
    <dbReference type="EnsemblBacteria" id="AFZ54452">
        <property type="protein sequence ID" value="AFZ54452"/>
        <property type="gene ID" value="Cyan10605_2369"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2369"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2516"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_5_3_3"/>
    <dbReference type="OMA" id="PANEIIG"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00884">
        <property type="entry name" value="beta_CA_cladeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045066">
        <property type="entry name" value="Beta_CA_cladeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="284" mass="32168" checksum="F104A8B404C4893F" modified="2013-03-06" version="1">MKKLIEGLHRFQAGYFKSHQDLFESLSHGQNPRILFITCSDSRIDPNLITQANVGELFVIRNAGNIIPPFGATNGGEGAAVEYAIAALGIEQVIVCGHSHCGAMKGLLKMSKLAEDMPLVYEWLKQAEATRRLIKENYSHVPEENLLRITVAENVLTQLENLSTYPIIRSRLHQGKLSLHGWVYNIERGEVLTYDPVIHDFVTLEQRNNSPEPEYIYNLYPSCSVSQAEGCRTYGIEEDNNNHNITHHQIAHTATHTQNNRNPNLPRSNRLSQEQAERIYRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W3</accession>
    <name>K9Z6W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220653.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2865"/>
    <dbReference type="EnsemblBacteria" id="AFZ54931">
        <property type="protein sequence ID" value="AFZ54931"/>
        <property type="gene ID" value="Cyan10605_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2865"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3045"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_3"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Rhodanese" evidence="13">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="371" mass="39618" checksum="10F187E8221F6EE0" modified="2013-03-06" version="1">MPVVATKLDQPSTTYHVKAGWKGLIEEYKHYLPVTESTPIITLREGNTPLIPVSSISKMIGRNVKVYVKYDGLNPTGSFKDRGMTMAISKAKEAGAQAVICASTGNTSAAAAAYATRAGMKAFVIIPDGYVALGKLAQALIYGAEVLAIDGNFDDALTIVREMAESYPVTLVNSVNPYRLEGQKTAAFEVVDTLGYAPDWLAIPVGNAGNITAYWMGFCQYHSENKCDILPKMMGFQAAGSAPFVEGHQVLKPETIATAIRIGNPANWEKALSVREASQGQFNAVTDEEILEAYRILGREEGVFCEPASAASVAGVLKLKEQIPDNGTVVCVLTGNGLKDPDSAMKLSESGIRGGIKADLNEVARIMGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z9</accession>
    <name>K9Z6Z9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">Cyan10605_2255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220064.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2255"/>
    <dbReference type="EnsemblBacteria" id="AFZ54340">
        <property type="protein sequence ID" value="AFZ54340"/>
        <property type="gene ID" value="Cyan10605_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2255"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2396"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_3"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="687" mass="72839" checksum="8F900E0C4B0A078D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z718</accession>
    <name>K9Z718_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium protoporphyrin O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220260.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2456"/>
    <dbReference type="EnsemblBacteria" id="AFZ54537">
        <property type="protein sequence ID" value="AFZ54537"/>
        <property type="gene ID" value="Cyan10605_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2456"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2601"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066342_1_0_3"/>
    <dbReference type="OMA" id="LDVFIHY"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046406">
        <property type="term" value="F:magnesium protoporphyrin IX methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010251">
        <property type="entry name" value="Mg_prot_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010940">
        <property type="entry name" value="Mg_prot_MeTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07109">
        <property type="entry name" value="Mg-por_mtran_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02021">
        <property type="entry name" value="BchM-ChlM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51556">
        <property type="entry name" value="SAM_MT_MG_PIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mg-por_mtran_C" evidence="1">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26089" checksum="28D3352FD818BE13" modified="2013-03-06" version="1">MVNTTKKTIDDKTVVKEYFNATGFERWRNIYGEGKVNKVQLDIRQGHQQTIDTVVSWLKDDGNLSQLSICDAGCGVGSLTLPLAQEGATVYASDISAKMVGEAAERIKQVMKNPRNIRLGVQDLESIRGSYDTVICLDVLIHYPTEDAAKMINHLSSLTKSRLILSFAPKTFFLTLLKRIGEFFPGPSKTTRAYQHKEEDIVKILQDNGFQIKRTGMTSTSFYYSRILEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z730</accession>
    <name>K9Z730_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ordered locus">Cyan10605_2291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220099.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2291"/>
    <dbReference type="EnsemblBacteria" id="AFZ54375">
        <property type="protein sequence ID" value="AFZ54375"/>
        <property type="gene ID" value="Cyan10605_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2291"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2433"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_3"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="205"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="32782" checksum="0006DF10EDDB7209" modified="2013-03-06" version="1">MSNPDSIVVKVPATTANLGAGFDCIGAALEFYNEFAFSLSQDDTTFTVEGEGADKITLDENNLLYQSFLYYYQQLNLTPPKVNISIKINVPLARGLGSSATAIIAGLLGANHFSSNSLTQTELLEMAIALEGHPDNVVPALLGNCILSVGEKGNWHFVPINCHEKIKFIVAIPDFELSTESARKVLPPHLTYSEAVYNIAHLGLLIKALETGNEDWLREALEDKLHQPYRKSLIKGYDEIYQAVVKGGGYGMVISGAGPTLLALTSEQHQETVTQAMAQTWASLGVNAIVKCLNLNTQGAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z779</accession>
    <name>K9Z779_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name evidence="2" type="ordered locus">Cyan10605_2135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219948.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2135"/>
    <dbReference type="EnsemblBacteria" id="AFZ54223">
        <property type="protein sequence ID" value="AFZ54223"/>
        <property type="gene ID" value="Cyan10605_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2135"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2270"/>
    <dbReference type="eggNOG" id="COG2377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_3"/>
    <dbReference type="OMA" id="GQTIRHE"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="41818" checksum="CAC842C92CA2FCC9" modified="2013-03-06" version="1">MIIIGLMSGTSVDGIDAAIVNIEGQGLDLKVDLLVGQTFPYSPSLREEILQVCAGKPLSMEELSKLDNAIASEFAQAVTSIIPDDLKVDLIGSHGQTVYHQPPQKNQLGYTLQLGRGDLISYLTGINTVSNFRVADIALGGQGAPLVSKIDVCLYRHPHHHRCLQNIGGIGNATYLPSSHTPQWQEKIMGWDTGPGNVLIDLAVQELTNNQQKFDFNGEWSRQGKPCQVLVKKWLNQDFFKQKPPKSTGRELFSPHYLQQCLKDAQTYNLSSADCLATLTELTVASIADSYHRFLPSPPHEVVLAGGGSRNSYLKERLQAHLPHSRLLNSDDLGISSEFKEAIAFAILAYWHINNFPGNLPQVTGAKKEVILGQHYLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z787</accession>
    <name>K9Z787_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220330.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2526"/>
    <dbReference type="EnsemblBacteria" id="AFZ54607">
        <property type="protein sequence ID" value="AFZ54607"/>
        <property type="gene ID" value="Cyan10605_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2526"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2680"/>
    <dbReference type="eggNOG" id="ENOG502Z85P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111454_0_0_3"/>
    <dbReference type="OMA" id="HCRQTIP"/>
    <dbReference type="OrthoDB" id="1385439at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013472">
        <property type="entry name" value="CHP02652"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09654">
        <property type="entry name" value="DUF2396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02652">
        <property type="entry name" value="TIGR02652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="20103" checksum="7B2A1DA723A048F9" modified="2013-03-06" version="1">MTNTNLQYPIFGPQIKCPHCRQTIDALTLTDSYLCPRHGAFEANPETEVLVHLQSGRQWRLWEHKWYRQHTHPDGIRFEIHEALDRLYTEGYRATKVIIAERYHNLISSYLDKGNNWQGNQESKLYKLYGLPVEFSHKSDAEPCWEVINFVLEKEKGTPSRYPYFRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I7</accession>
    <name>K9Z7I7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220268.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2464"/>
    <dbReference type="EnsemblBacteria" id="AFZ54545">
        <property type="protein sequence ID" value="AFZ54545"/>
        <property type="gene ID" value="Cyan10605_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2464"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2609"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_0_3"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="296"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="392" mass="43237" checksum="EF032ACBB86824A0" modified="2013-03-06" version="1">MLNPNLEAIELNKEEYERYARHIILPEVGLEGQKRLKAASVLCVGTGGLGSPLILYLAASGIGRIGIVDFDVVDTSNLQRQIIHSTSWVGKPKIESAKHRILEINPACQVDLYETRLSSENALSIFEPYDIIIDGTDNFPTRYLVNDACVLLNKPNVYGSIFRFEGQATVFNYEGGPNYRDLYPEPPPPGMVPSCAEGGVLGVLPGIIGTIQATEAIKIILGAETTLSGRLLLFNAWDMKFRELKLRPNPVRPVIEKLVDYEEFCGIPQAQAESEKAQEELPEITVQELKFLLESHPHDYVLIDVRNPNEHEIARIPGSVLVPLSDIESGEGVQKIRELVDVKGHRLIAHCKMGGRSTKALQILKEAGIEGINVKGGILAWSQEVDPSVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S2</accession>
    <name>K9Z7S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220358.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2555"/>
    <dbReference type="EnsemblBacteria" id="AFZ54635">
        <property type="protein sequence ID" value="AFZ54635"/>
        <property type="gene ID" value="Cyan10605_2555"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2555"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2712"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_3"/>
    <dbReference type="OMA" id="AWCPYCN"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="23840" checksum="B960A9EE4AD4CCCF" modified="2013-03-06" version="1">MNLQQELNNLSQQMQQKLSDDVKKIMAKTAQELIDSQISEKALKKGDKIPSFALPNSTGKLINISDILATSKAVISFYRGGWCPYCNLELKALQQRLPEIKEAGANLVAISPQTPDNSLSTIEKQELTFEVLSDVGNNVAKEFGLVFTVPEILRNIYHSFGIDLPKSNGDDSYTLPLPATYIVDRNGTIIYSFVDTDYTKRVDPQEIIDILKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X3</accession>
    <name>K9Z7X3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="6">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_3245</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221009.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3245"/>
    <dbReference type="EnsemblBacteria" id="AFZ55291">
        <property type="protein sequence ID" value="AFZ55291"/>
        <property type="gene ID" value="Cyan10605_3245"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3245"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3459"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_3"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="581"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="12">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1231" mass="137301" checksum="0D0A30D9122477ED" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z853</accession>
    <name>K9Z853_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glk</name>
        <name evidence="3" type="ordered locus">Cyan10605_2845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220634.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z853"/>
    <dbReference type="STRING" id="755178.Cyan10605_2845"/>
    <dbReference type="EnsemblBacteria" id="AFZ54912">
        <property type="protein sequence ID" value="AFZ54912"/>
        <property type="gene ID" value="Cyan10605_2845"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2845"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3024"/>
    <dbReference type="eggNOG" id="COG0837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042582_0_0_3"/>
    <dbReference type="OMA" id="NNHWRLS"/>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00524">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00749">
        <property type="entry name" value="glk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="37644" checksum="2F362DB2C229DC99" modified="2013-03-06" version="1">MKVLIGDIGGTKTILRLVEINKNNHYETIKQIKYSSQEYQTFSYMIEKFLDGFAIDKICIAIAGPINNNSCKLTNLNWHIKGDELAQEFHCQEAYLLNDFAAVSYGIINLKESELFTLQEGEKNNNSPIAVIGAGTGLGQSFLIPEKNKYRVFATEGGHSDFSPKNELEWQLLKYLKNKFGWERISAERVISGQGIVAIYQFLRDTKFAPESEEISSQIKQWEQGDNTIDPGEIIGQSALTKSDILTTQTMTMFLDAYAGEIGNFALKILPYGGIYIAGGIITKILPLVQDSDFVNTFLHKGRMKPLLEKMPLKVVTNTEVALQGLLYYESIALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z893</accession>
    <name>K9Z893_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220321.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2517"/>
    <dbReference type="EnsemblBacteria" id="AFZ54598">
        <property type="protein sequence ID" value="AFZ54598"/>
        <property type="gene ID" value="Cyan10605_2517"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2517"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747771_0_0_3"/>
    <dbReference type="OMA" id="LVHDLFF"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="305" mass="34015" checksum="5E667F10AED0512B" modified="2013-03-06" version="1" precursor="true">MNKNKQLLTILVFLISIVFCFCQNTLNAYAYQKEDLLKLENYHKCIKCDLEKYHFNSKKIDLQKANLKASNLHKANLKNNNISQVNFNQADLSFVNLENTTAIKTNFKQANISHSNLKRSNFSNSDFSQAQLNNANLSYSTLNKSNLSRSHLISAKLIQTNLTATNLHKANLSQADLTEANLSSKSKKEITNLSQANLSETRIINAEIKGVNLIKANLFHADLEGSDLQNSNLKKANLAQANLSHVNLTNANLKKANLINSSLVYAKLDHCDLRKANLEKANLTGTNIETCNLKGTIMPDGTIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E3</accession>
    <name>K9Z8E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220572.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2783"/>
    <dbReference type="EnsemblBacteria" id="AFZ54850">
        <property type="protein sequence ID" value="AFZ54850"/>
        <property type="gene ID" value="Cyan10605_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2783"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2957"/>
    <dbReference type="eggNOG" id="ENOG5032RPJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2130915_0_0_3"/>
    <dbReference type="OMA" id="FFLSEGW"/>
    <dbReference type="OrthoDB" id="1740548at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="12136" checksum="5564889DE3E1F4E3" modified="2013-03-06" version="1">MKYFFLTAGWTYNRIWERSGLWNEMVWRRQPYIKSLPIGIIENDQTLWLYEVEDTIIMVEVSPLSDNVKFDKNIGQVVLKRLIDSDQVLDTLIKAQKVVKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I5</accession>
    <name>K9Z8I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220756.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2977"/>
    <dbReference type="EnsemblBacteria" id="AFZ55037">
        <property type="protein sequence ID" value="AFZ55037"/>
        <property type="gene ID" value="Cyan10605_2977"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2977"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3170"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080449_0_0_3"/>
    <dbReference type="OMA" id="LATKQCQ"/>
    <dbReference type="OrthoDB" id="1677419at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938711" evidence="2">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="27703" checksum="7C781886F4E82B4F" modified="2013-03-06" version="1" precursor="true">MNKTILLTSTLLMSLIATFPCQAENIEHLNQLLQTKQCENCDLADAGLVMINLQGANLRGANLVGANLSRADLTGADLRGANLTNASFFGANLSGANLSGANAYNTDFRNSYVQGVIIEGLDLSMAHIQGTVGIPATAASAEQFYVWGLSEDKDGNYKAAADYYSQAINLNPELAQAYLGRAVIKSRYGQVSAAIKDAETAQGLFETQNNSEGYLLSSRFVQLVKARAEAEEKDGNQGSPQFVQIVNSIAPMVLKLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L4</accession>
    <name>K9Z8L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220406.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2608"/>
    <dbReference type="EnsemblBacteria" id="AFZ54683">
        <property type="protein sequence ID" value="AFZ54683"/>
        <property type="gene ID" value="Cyan10605_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2608"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2771"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_3"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30541" checksum="2EA420FFD62B4A6F" modified="2013-03-06" version="1">MPKNKERIDILLTEKQLCDTRTTAQKLIRAGKVRVKGQIVDKPGTLVSLDSIIEVESEPPFVSRGGEKLIKAIASFKIEVKGRICLDGGISTGGFTDCLLQQGAKKVYGVDVGYGQVAWKIRQDERLTLLERTNFRHLTPEKLYQGETPADLGVMDLSFISLTKVLAKLWELLITPRDVILLVKPQFEVGKEKVGKNGVVRDYRLQAEAINQVLRHALEIGWQYQNLTYSPITGPAGNIEYLLWLSEDINNVNPTLEQIEQLTKSSQKEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N1</accession>
    <name>K9Z8N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C-5 cytosine-specific DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221242.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3489"/>
    <dbReference type="EnsemblBacteria" id="AFZ55524">
        <property type="protein sequence ID" value="AFZ55524"/>
        <property type="gene ID" value="Cyan10605_3489"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3489"/>
    <dbReference type="eggNOG" id="ENOG5030M31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1945171_0_0_3"/>
    <dbReference type="OrthoDB" id="1991793at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="15329" checksum="7A850DEB9D135AD7" modified="2013-03-06" version="1">MSQKFHFIDSPRIIPRGKQKIPPSGHLAPVIEFKNGKAYPAISGVDLQERQARKLDCPEDYPHWFTWFYQWAEKDELTDLWRTNSIRVPPCLVKFVRYMIDRDKSISEILLFIRKNKNSSRSHKLDIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N9</accession>
    <name>K9Z8N9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction modification system DNA specificity domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220679.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2897"/>
    <dbReference type="REBASE" id="58393">
        <property type="entry name" value="S.Cap10605ORF2897P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54960">
        <property type="protein sequence ID" value="AFZ54960"/>
        <property type="gene ID" value="Cyan10605_2897"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2897"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3084"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_10_3_3"/>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="145"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="36921" checksum="1EB10C18FC9EC4B8" modified="2013-03-06" version="1">MNEPTVWTTQVTKEANKDDLLISVRAPLGDVNFNPFDKICIGRGLAAIQHESLLLKKYLFEYLVSHQFLFEGYKGATFEAISTDDLRQIKIPLPPLEIQEEIVKACQVIDEEFEKAETIIKSEKEKIENLMKQTLDTFNNKDYQITIGNLTETSSGGTPKSSNSLYYQGGKIPWINSGEVAKGEIYYAEKFITDLGLQNSNAKIFPEETVLLAMYGATAGKCAVLKIKASTNQAICGIFPNDEFISKFLKYQLDFMYEDILGLRHGIARENLSQEIIKNILVIIPPKEKQQEIIFEIEKCEAKIKEAQIIINGIAKRKEAVIYQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q4</accession>
    <name>K9Z8Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-lysine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220826.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3050"/>
    <dbReference type="EnsemblBacteria" id="AFZ55107">
        <property type="protein sequence ID" value="AFZ55107"/>
        <property type="gene ID" value="Cyan10605_3050"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3050"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="EFIYIIG"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="28161" checksum="F03450535F101C74" modified="2013-03-06" version="1">MTKSSLPIIICENLHKSYGTLEVLKGVNVQFHQGDVVSIIGPSGCGKTTFIRCLNRLESVTSGTLQVMGIDISDHTISNNKLRQLRSKVSMVFQHFNLFPHLTILDNLTLAPQKVLKKSPQEAKEMALHYLDKVGLSSKANFYPQQLSGGQKQRVAISRSLCMQPDIILFDEPTSALDPELVGEVLTTMRQLAEEGMTMIVVTHEMQFARDVSNLVLFFNQGIIEEMGNPHQIFSQPKSDRLKTFLKRTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W1</accession>
    <name>K9Z8W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220754.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2975"/>
    <dbReference type="EnsemblBacteria" id="AFZ55035">
        <property type="protein sequence ID" value="AFZ55035"/>
        <property type="gene ID" value="Cyan10605_2975"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2975"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3168"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029821_0_0_3"/>
    <dbReference type="OMA" id="EDYMLPV"/>
    <dbReference type="OrthoDB" id="878131at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044200">
        <property type="entry name" value="At5g03900-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47380">
        <property type="entry name" value="PTHR47380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="432" mass="49738" checksum="D6036179D6693DAD" modified="2013-03-06" version="1">MASPNSAIMQSVEKLNYRVTVGDVATQSGLDVKIVQQELLQLANDTSGHLQVAETGDIVYLFSSNFRSILRNKYWQLRWKKWLQKAWDIVFYLIKISFGIILISSIIIMLLAIIVIVVAISSSKDGDNNGGDSRRGGGFFFLPQFWISPDFFWMFSPNYEERRYQRQRNNKTENELNFLESIYSFLFGDGNPNRNLEERRWREIATVIKNNNGAIIAEQVAPYLDNISNQEDEDYILPVLIRFNGYPEVSDKGEIIYYFPELQVTAKERNKASVAPYLKENLWQFSIASSGQKIGAIALGGVNIVLALMLGTLLTPELAQEIGGFILFVNSIYGILVAYAVSYLTIPLIRYFWLQNRNKKVVERNNQRQNRANILESNSQLQNKINYAQQFAQQKVITGEDLAYSTEKDLLDQEIEQRDKIDEEWRKKLMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Y6</accession>
    <name>K9Z8Y6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ordered locus">Cyan10605_2765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220555.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2765"/>
    <dbReference type="EnsemblBacteria" id="AFZ54833">
        <property type="protein sequence ID" value="AFZ54833"/>
        <property type="gene ID" value="Cyan10605_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2765"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2936"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_3_3"/>
    <dbReference type="OMA" id="PCQSVNP"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="725" mass="81127" checksum="F294F7BF210A22F6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z5</accession>
    <name>K9Z8Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease (SNase domain-containing protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220794.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3016"/>
    <dbReference type="EnsemblBacteria" id="AFZ55075">
        <property type="protein sequence ID" value="AFZ55075"/>
        <property type="gene ID" value="Cyan10605_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3016"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_5_1_3"/>
    <dbReference type="OMA" id="RAQQWAR"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="160" mass="18397" checksum="AB55264CF7ADB504" modified="2013-03-06" version="1" precursor="true">MIKNLLVISLLIIFLFGCNSSHKFGGINAQINRVISGQTIEIFVDKKNVSFRLMGLRIPSNINYDKKLAQQHLIQLLTSNYHYPLNSVIVKVETKLNQKDKYGRLTGYVWLNNQLINRKVLEGGWAIASLEYTDGKYDRDLLQGEEYARIMGNGIWKINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z931</accession>
    <name>K9Z931_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220940.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3171"/>
    <dbReference type="EnsemblBacteria" id="AFZ55222">
        <property type="protein sequence ID" value="AFZ55222"/>
        <property type="gene ID" value="Cyan10605_3171"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3171"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_4_3_3"/>
    <dbReference type="OMA" id="YQEAYGV"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="10455" checksum="EB8DD5C645BED80B" modified="2013-03-06" version="1">MKENKHKITVIVKLFAIYQETYQKEEITLKLEKEITVKQLLQDFIVQEKPELKPWENITRFAVNLQFVEPNFILNDQDEIALIPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z935</accession>
    <name>K9Z935_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220620.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2831"/>
    <dbReference type="EnsemblBacteria" id="AFZ54898">
        <property type="protein sequence ID" value="AFZ54898"/>
        <property type="gene ID" value="Cyan10605_2831"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2831"/>
    <dbReference type="HOGENOM" id="CLU_1537539_0_0_3"/>
    <dbReference type="OrthoDB" id="2172743at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="20641" checksum="9FE1ECFD0722BDE0" modified="2013-03-06" version="1">MNNFTQSIIILNRRKKQVSEELEEAKSKLLMWSKRVNLSLENNRFDLLKEASLQENLYIDKVKSLESQLSQLSTEIDKTEQKQSRSILPNFQPTLPLSDFEKMEREINDNDHLSQKEELDIEEEIKLIKNYLKYATNALEKLESKVLKNNKNQDIFDIANIDDELEELRKQLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z954</accession>
    <name>K9Z954_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3204"/>
    <dbReference type="EnsemblBacteria" id="AFZ55252">
        <property type="protein sequence ID" value="AFZ55252"/>
        <property type="gene ID" value="Cyan10605_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3204"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_5_0_3"/>
    <dbReference type="OMA" id="YLRFQLT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21018" checksum="168C1C2B3E09F6A2" modified="2013-03-06" version="1">MSMSESVSISSKLEQLLPQLFENKDLRGDRYLRFQLDAGITALIPIDDVRESLLIDRDKITPVPKMSPFIMGVINSRDRVFLVMDLPLLVNLTPISAYAREYNLVVVNIAPFIPNNNSHSSELWLGLAVHKIEGITRTEQKPIKDDSSTPLFSEKSLDEYIYGWIIEQNQTLAVLDLVKIVKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D8</accession>
    <name>K9Z9D8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221060.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3296"/>
    <dbReference type="EnsemblBacteria" id="AFZ55342">
        <property type="protein sequence ID" value="AFZ55342"/>
        <property type="gene ID" value="Cyan10605_3296"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3296"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2248893_0_0_3"/>
    <dbReference type="OMA" id="IAVIIWD"/>
    <dbReference type="OrthoDB" id="1856403at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12350" checksum="FF6ECF5D9963D338" modified="2013-03-06" version="1">MQEFSDFLRHKCAYVATATFKPGKFPEAQKLFEEAIASYSQGFKGAYLFQKPNTEEGIAFIIWEKIEDMEENKNEVHNQIMKQMKHLFATPPQTNFYDVLTEFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G6</accession>
    <name>K9Z9G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220752.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2973"/>
    <dbReference type="EnsemblBacteria" id="AFZ55033">
        <property type="protein sequence ID" value="AFZ55033"/>
        <property type="gene ID" value="Cyan10605_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2973"/>
    <dbReference type="HOGENOM" id="CLU_137178_0_0_3"/>
    <dbReference type="OrthoDB" id="2070443at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="14263" checksum="974CAB5EA0DC2FE9" modified="2013-03-06" version="1">MSVFIPSQIVALDYQNKSLYCEVIDACCVADPFGIASRDLCWVRPIILVDKMTEKTDYLTDKNDIYDLRFTSDLLWNIKDFRIVLDTEYIEFLVNLSDFEFDDDKLKLAREKLKLFIKEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L5</accession>
    <name>K9Z9L5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221135.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3375"/>
    <dbReference type="EnsemblBacteria" id="AFZ55417">
        <property type="protein sequence ID" value="AFZ55417"/>
        <property type="gene ID" value="Cyan10605_3375"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3375"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3593"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_3"/>
    <dbReference type="OMA" id="GAWIQDP"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30564" checksum="A1F1D8B82801144A" modified="2013-03-06" version="1">MTDIKLLILDIDGTISGKSNQVTEKVKNAIKEAQGKGVKVGLATGRMFCSALRFHQEINADLPIIAYNGAWMQRVDNQEILLHQPVNKNIAQELMRYFREKQIDNELEIHLYYDDQLYVENFSEKTDFYVTRSGINFNVVEKLETLLNNHPTKVLAQSPDADFIGNLLQDLQIRYSTDELYLTQSNPIYLEATQANVNKGSTVKYLVEKILGYNPQEVMAIGDNYNDYTMLDYVGLGIAMGDAPPEIRAIAAGVTQDVENDGVADAIASYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA26</accession>
    <name>K9ZA26_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221163.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3403"/>
    <dbReference type="EnsemblBacteria" id="AFZ55445">
        <property type="protein sequence ID" value="AFZ55445"/>
        <property type="gene ID" value="Cyan10605_3403"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3403"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3624"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_3"/>
    <dbReference type="OMA" id="YVGEYGK"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="25019" checksum="D8DCB9BA061B1420" modified="2013-03-06" version="1">MFIITNDDGINAEGIKALKEIITEDKVIIAPDRALSGCGHQVTTKEGITVTETKPQEYAISGTPADCVRLGISKIFPSATWVLSGINAGGNLGSDIHISGTVAAVREAAIHGLGAIAISHVIKYPQPINWDIAKKLSKKVLKKLLNKDLPKGCFWNVNLPPLDYVSNPDIVFCSPSIDPLPLNFKQEGNQYFYRGEYWQRKRTIDTDVDVCFSGNIAVSLISINGNSTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA89</accession>
    <name>K9ZA89_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-6 DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221228.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3474"/>
    <dbReference type="REBASE" id="58387">
        <property type="entry name" value="Cap10605ORF3474P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55510">
        <property type="protein sequence ID" value="AFZ55510"/>
        <property type="gene ID" value="Cyan10605_3474"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3474"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3699"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009503_0_0_3"/>
    <dbReference type="OMA" id="ENVFNIM"/>
    <dbReference type="OrthoDB" id="45009at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="322"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="709"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1078" mass="125852" checksum="3F9F5F8F1FDAC897" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAA0</accession>
    <name>K9ZAA0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221011.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3247"/>
    <dbReference type="EnsemblBacteria" id="AFZ55293">
        <property type="protein sequence ID" value="AFZ55293"/>
        <property type="gene ID" value="Cyan10605_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3247"/>
    <dbReference type="eggNOG" id="ENOG502ZV3X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117669_0_0_3"/>
    <dbReference type="OMA" id="YKLDTCG"/>
    <dbReference type="OrthoDB" id="1669276at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013481">
        <property type="entry name" value="CHP02664_NO3_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09655">
        <property type="entry name" value="Nitr_red_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02664">
        <property type="entry name" value="nitr_red_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="18144" checksum="7F3935D14578BB9A" modified="2013-03-06" version="1">MTIFFKFEQDFVNSLRCIPMIVRYKLDTCGVKLKLNHWHEFNKEEKDFLVHKPCKTTQEIKEYANYLQELVREKTGEYAKNLEIESNPQWSNIEEIPEQVSKKAEEFNFQLTLSQWQNLDDLQRFVLIKLSKSGHENRNFLPALKEFKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD0</accession>
    <name>K9ZAD0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenite efflux ATP-binding protein ArsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221046.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3282"/>
    <dbReference type="EnsemblBacteria" id="AFZ55328">
        <property type="protein sequence ID" value="AFZ55328"/>
        <property type="gene ID" value="Cyan10605_3282"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3282"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3497"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033948_0_0_3"/>
    <dbReference type="OMA" id="WYVRRFR"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="3">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="40149" checksum="2EB440166A179EFC" modified="2013-03-06" version="1">MAFILTFLGKGGVGCTTMAIASAKKYAQIGKKVLLAVQDSTPSFSIQLGANVTSEISEISPNLDVVQLHSTQLLEASWEQLKQLEAKYLRSPVLNNIYGQELALLPGMDCALALNYIREQDSKYDVIIYDGKTSLNSLRMFGIPDTLSWYIRRVKNLLENSDIVKALSPFVQPVSSAIFNVTWSPDNLSNESTKEADQILEQGKKAINDPSRVCAFLVTNQTLEAIATCKYWWGSAQQIDLTVGGVLLNQDSITEDITTTFKPLNISSIPSKKSDNWENLTQALPDFESQAKQAPRPIIIDTVAREVKVFLPGFDKKQVKLSQSGPEITISAGDQRRNIFLPSPLKGQSVKGAKFQDAYLVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAV1</accession>
    <name>K9ZAV1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3482"/>
    <dbReference type="EnsemblBacteria" id="AFZ55518">
        <property type="protein sequence ID" value="AFZ55518"/>
        <property type="gene ID" value="Cyan10605_3482"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3482"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3708"/>
    <dbReference type="eggNOG" id="ENOG5033AV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186854_0_0_3"/>
    <dbReference type="OMA" id="MMTLPEM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11751" checksum="9B1AD304423ECC7D" modified="2013-03-06" version="1">MIKSFDQLSAQEQDNLLEILRQRRSQLTKGEDLPNESELEEAITPSTAKVETVDDLKVDLGKEKQGFWSALQDFRRRVDLESLDDDTFDNLRDKSPGRDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZE6</accession>
    <name>K9YZE6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218016.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0127"/>
    <dbReference type="EnsemblBacteria" id="AFZ52284">
        <property type="protein sequence ID" value="AFZ52284"/>
        <property type="gene ID" value="Cyan10605_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0127"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.129"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_5_2_3"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10269" checksum="848ACE1116BC1BC0" modified="2013-03-06" version="1">MGKVILIFLINIYRQYISPLFPPSCRFQPTCSQYAIAAISTFGVWRGSYLAIKRILRCHPFHPGGYDPVPSSLEELLLNNKKKAKDKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZM4</accession>
    <name>K9YZM4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_IS240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218096.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0208"/>
    <dbReference type="EnsemblBacteria" id="AFZ52364">
        <property type="protein sequence ID" value="AFZ52364"/>
        <property type="gene ID" value="Cyan10605_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0208"/>
    <dbReference type="eggNOG" id="COG3316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452212_0_0_3"/>
    <dbReference type="OMA" id="WVIRLVP"/>
    <dbReference type="OrthoDB" id="1655560at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS240" evidence="2">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="23002" checksum="FEDB96CEA22BA0FD" modified="2013-03-06" version="1">MRRSNVNQWDQIREEVILLCIQWYVTENLTYTQLKKVMGQRGFKIDPRTINYLVKEYSPLAKKRAMETLRKKRRGWRIVQIPFNLRGKKKYLYRALDAQGNTLDFIITNMRNKEKARVFFEQTIPKNLEQRLSKILSNRQILKVEKNNLITGSIFVIILVIIGFIVIKQKDNNQDNNSSNAVYGRGLINNALDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZM7</accession>
    <name>K9YZM7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218101.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0214"/>
    <dbReference type="EnsemblBacteria" id="AFZ52369">
        <property type="protein sequence ID" value="AFZ52369"/>
        <property type="gene ID" value="Cyan10605_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0214"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.224"/>
    <dbReference type="eggNOG" id="ENOG5032Y24">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160065_1_0_3"/>
    <dbReference type="OMA" id="DQQHPLY"/>
    <dbReference type="OrthoDB" id="1749590at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021705">
        <property type="entry name" value="DUF3288"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11691">
        <property type="entry name" value="DUF3288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="11378" checksum="1540CC8637AE1D97" modified="2013-03-06" version="1">MVIDQKHPLGHIDREIVKQIFVEGKNDYNLAEVARLKIRYQNFPGARDIQFDLDSILQQWEMTEDELFAESRKLHQNSSIYRKKVKGDEEREDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZU1</accession>
    <name>K9YZU1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0285"/>
    <dbReference type="EnsemblBacteria" id="AFZ52434">
        <property type="protein sequence ID" value="AFZ52434"/>
        <property type="gene ID" value="Cyan10605_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0285"/>
    <dbReference type="eggNOG" id="ENOG5032Z0G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420636_0_0_3"/>
    <dbReference type="OMA" id="DSWKGES"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029013">
        <property type="entry name" value="HP0062-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158414">
        <property type="entry name" value="SSF158414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="13337" checksum="2C326F8C77CC4FE8" modified="2013-03-06" version="1">MLEYKNNFKGYFKLLGGNLMTQDIDVDIDELKEFIDTLQYFQDVMSDRFQAVEYDWNRCDESWEGESKKRFTSDFEEVYDRTKRTLTAGEDALEWLKKYYQILEDFERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZV0</accession>
    <name>K9YZV0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218176.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0296"/>
    <dbReference type="EnsemblBacteria" id="AFZ52444">
        <property type="protein sequence ID" value="AFZ52444"/>
        <property type="gene ID" value="Cyan10605_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0296"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.307"/>
    <dbReference type="eggNOG" id="ENOG50330D4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2663116_0_0_3"/>
    <dbReference type="OMA" id="HERNWNS"/>
    <dbReference type="OrthoDB" id="1990892at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8529" checksum="B388073CA70C784D" modified="2013-03-06" version="1">MAILITLFVIGWLAVSIIGTQAYFRGEQSKTIHERNWNSESFDQLAQSVTGQETDYLVRVPAYYFDPRVTRQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZV3</accession>
    <name>K9YZV3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218213.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0334"/>
    <dbReference type="EnsemblBacteria" id="AFZ52481">
        <property type="protein sequence ID" value="AFZ52481"/>
        <property type="gene ID" value="Cyan10605_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0334"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.349"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_1_3"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="39182" checksum="7459814CF3A48FB2" modified="2013-03-06" version="1">MSVLAAIAVLGILIVVHELGHFGAARLQGIHVNKFSIGFGPVLAKYDGKETEYALRAFPLGGYVGFPDDDPDSKIPLDDPNLLRNRPVFDRAIVISAGVIANLIFAYLLLVGQVATVGVQDFNYQQGVLIPEILTEIESPAQKAGLKSGDVVLAIDNQTLPTQEDAIDILRQTIQKSPNQTLNFTIKRGEETLSLPIIPELGENGQGKIGVMLAPNGEIIKRRPQNIIEPFTLAAEQFERYTTLTVQGFGQLITNFQENARQVAGPVAIVAVGAELAKNDLGNLFQFGALISINLAIINILPLPALDGGQLAFLVVEGITGKPLPNKLQEGIMQTGLVLLLGLGVFLILRDTANLAFFQQLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z086</accession>
    <name>K9Z086_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA</name>
        <name evidence="6" type="ordered locus">Cyan10605_0435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218310.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0435"/>
    <dbReference type="EnsemblBacteria" id="AFZ52579">
        <property type="protein sequence ID" value="AFZ52579"/>
        <property type="gene ID" value="Cyan10605_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0435"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.459"/>
    <dbReference type="eggNOG" id="COG0831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_3"/>
    <dbReference type="OMA" id="MQLTPHE"/>
    <dbReference type="OrthoDB" id="1826954at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="11001" checksum="1DB2EE047419A22F" modified="2013-03-06" version="1">MELSPQEKDKLLIFTAGLLAERRKAKGLKLNYPEAVAYISAAILEGAREGLTVAELMSYGRTLLTKNDVMEGISEMVEEVQVEATFPDGTKLVTVHHPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z090</accession>
    <name>K9Z090_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="9">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218315.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0440"/>
    <dbReference type="EnsemblBacteria" id="AFZ52584">
        <property type="protein sequence ID" value="AFZ52584"/>
        <property type="gene ID" value="Cyan10605_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0440"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.465"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_1_1_3"/>
    <dbReference type="OMA" id="IGVPNKR"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="247" mass="27837" checksum="E8A415568DD3B312" modified="2013-03-06" version="1">MNDNNLITGLIHSTESCGTVDGPGIRFVVFTQGCPLRCLYCHNPDCRHIENGKKITVGELIEEIEKYHSYFDYSGGGVTVTGGEPLMQPEFVKAIFQECHKKGIHTALDTSGYVQLNQAKEVLESADLVLLDIKSYDPEIYRRVTSVSLQPTLDFANYLAKINKPTWIRFVLVPNLTDPDHNVQGLAEFVAGLKNVEKVEVLPFHKMGEYKWEQLGYDYQLKDTQTPSPELIAKVSEIFKRNGLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D1</accession>
    <name>K9Z0D1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="3" type="synonym">rpl24</name>
        <name evidence="6" type="ordered locus">Cyan10605_0514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218387.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0514"/>
    <dbReference type="EnsemblBacteria" id="AFZ52656">
        <property type="protein sequence ID" value="AFZ52656"/>
        <property type="gene ID" value="Cyan10605_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0514"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.544"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_3_3"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13247" checksum="176E5A360F152834" modified="2013-03-06" version="1">MRSLKTSKQKPARYKMHVKKGDTVQVISGKDKGKVGEILQAIPSDSTVIVKGVNIRTKHQKPRQEGESGQIVTYEAPIHSSKVMLYSEKEKVASRINYVITEEGKKVRKLKKTGEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D2</accession>
    <name>K9Z0D2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217904.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0011"/>
    <dbReference type="EnsemblBacteria" id="AFZ52172">
        <property type="protein sequence ID" value="AFZ52172"/>
        <property type="gene ID" value="Cyan10605_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0011"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125353_0_0_3"/>
    <dbReference type="OMA" id="ICLINEE"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="14096" checksum="140072693BA2D08D" modified="2013-03-06" version="1">MKLDYLIDTNIFICLINEELREAIPNGILGYSIITQIELLSFPLLEKEEENLIKRYLNTLSEIPLNKIIAEKTIYLRRKYNLKTPDAIILATAWECQSVLLSNDQKLTNIKEVSVISLKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D6</accession>
    <name>K9Z0D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="8" type="synonym">rps3</name>
        <name evidence="13" type="ordered locus">Cyan10605_0519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218392.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0519"/>
    <dbReference type="EnsemblBacteria" id="AFZ52661">
        <property type="protein sequence ID" value="AFZ52661"/>
        <property type="gene ID" value="Cyan10605_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0519"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.549"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_3"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="240" mass="27394" checksum="5B1E4CD4B39998AB" modified="2013-03-06" version="1">MGQKVHPIGFRLGITKEHSSCWYADKRNYPKLLQEDHKIRQYIDKNLANASIADVKIERKADQIDLSIHTARPGVVVGKGGQGIEKIRTDLQALLKNQRQFRVNVIEVTNVDASAALMAEFLTSQLERRVSFRRVVRQAIQRAQKAEVLGIKIQVSGRLNGAEIARTEWIREGRVPLHTLRADIDYSYKTASTIYGILGVKVWIFKGEIIPGEENLNLTANRNKPSRKKPRRQKFEDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0H0</accession>
    <name>K9Z0H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217939.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0046"/>
    <dbReference type="EnsemblBacteria" id="AFZ52207">
        <property type="protein sequence ID" value="AFZ52207"/>
        <property type="gene ID" value="Cyan10605_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0046"/>
    <dbReference type="HOGENOM" id="CLU_182787_1_0_3"/>
    <dbReference type="OMA" id="SGFQRWQ"/>
    <dbReference type="OrthoDB" id="2026414at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="60" mass="6937" checksum="97BBF7F4ABC6690A" modified="2013-03-06" version="1">MISSTIANNLPQDQEIWNSLQKAIAKSSGFQRWQKENKFDGTVEEQVTQYLRSTLETLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K6</accession>
    <name>K9Z0K6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218447.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0576"/>
    <dbReference type="EnsemblBacteria" id="AFZ52716">
        <property type="protein sequence ID" value="AFZ52716"/>
        <property type="gene ID" value="Cyan10605_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0576"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.608"/>
    <dbReference type="eggNOG" id="COG0387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_2_3"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="OrthoDB" id="988251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="214"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="38613" checksum="043451FDF4029FD7" modified="2013-03-06" version="1" precursor="true">MNKNLIFGILLIFIPISIAGHFLHWGEVVIFLSAALAIVPLAAFMGEATENIAVVVGPNLGGLLNATFGNATELILAFIALKSGFVQVVKATLTGSIIGNLLLVMGFAMFLGGLRFKEQNFQPATARLNASAMNLAVIAILLPTAVQYTSKGIPTTTMQTLSVAVAVVLISVYLLTLLFSMKTHSYLYDVGMAENETEEESESPHQPNILFWISILLVVTIGVAIESELLVDSLEEATADLGLPALFTGVIFLPIIGNAAEHATAVTVAIKNKMDLSVSVAVGSSLQIALFVAPVLVIIGWFIGQPMDLNFNPFELVAVAVSVLIANSISSDGNSNWLEGILLLATYVVIGLAFYFHPVIEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W4</accession>
    <name>K9Z0W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218572.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0705"/>
    <dbReference type="EnsemblBacteria" id="AFZ52841">
        <property type="protein sequence ID" value="AFZ52841"/>
        <property type="gene ID" value="Cyan10605_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0705"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.738"/>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050982_0_1_3"/>
    <dbReference type="OMA" id="HIIVCGC"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="38163" checksum="8DA3B231053B338B" modified="2013-03-06" version="1">MLDPYYQRLRKELIISSLGLAGVFIGGTLWYWLVEKWSLLDSAYMTMITLSTVGFSEVNPLDERSRLFTMGLILTGIIVIGYMVNRFTEAFLQGYFQQGIRLRQKRNVIDKLSGHYILCGFGRMGSYVAKEFTAEAIPFIILDSEQEEVEKASQMGYLALQGDATLDECLLMAKIETAICVVAALSSDADNLYTVISAKALNPTIRAIARASTEEAVKKLERAGADAVVSPYITGGKRLASAALRPQVMDFVDGILSGGEKSIYLEEFLLDENTCPCLGQTLIEAGLRAKSGALVVAIRRSNGILIAGPTGGSILEAGDSLICMGTAEQLRILNGILMPISAPRIPRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X3</accession>
    <name>K9Z0X3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218582.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0715"/>
    <dbReference type="EnsemblBacteria" id="AFZ52851">
        <property type="protein sequence ID" value="AFZ52851"/>
        <property type="gene ID" value="Cyan10605_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0715"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_3_0_3"/>
    <dbReference type="OMA" id="TILCEPL"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15727" checksum="C77113CF299B2B64" modified="2013-03-06" version="1">MKLLLDTNIWISGLLWGGVPREIISLTETNLASIYISNSLLQELEDTLTKSKLQKRLKQLNYSEKDLIDTVKSVTILCEPLSILKVEELRDFKDKIVLEAGLSIPVDFIITGDLDLLVLDSFRGIQILNPNDFKLKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y5</accession>
    <name>K9Z0Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217942.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0049"/>
    <dbReference type="EnsemblBacteria" id="AFZ52210">
        <property type="protein sequence ID" value="AFZ52210"/>
        <property type="gene ID" value="Cyan10605_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0049"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.51"/>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040984_0_0_3"/>
    <dbReference type="OMA" id="ASTQCLI"/>
    <dbReference type="OrthoDB" id="687829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="216"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="39315" checksum="08FA20E877BAC7B8" modified="2013-03-06" version="1">MVSSQSKHLLIASSEPYTGKTATILGIAHQLQKKGVKLGYGKPIGTCFNPNDGIQDEQDLQFISEILGLPPERVKAPLLFLDEKTITDYLKTINDDYQDTLKEYCDSIEGDLILLEGAGNLTQGKLFNLSVPEIVEKISAEVLLVVKYDGLLIVDQILHAKDVLGDRLLGVLINSIPNDALDHIESDLKPFFQSRGIDILGMLPTDRLLQSVSVRELVSQLNARVLCRENRLDLMVESLTVGAMNVNSALEYFRKGQNMAVVTGSDRTDLQLAALESSTNCLILTGHTPPQQLILARAEDLEIPILMVDCDTLTTVEIIDRAFGKVRLHETIKVECMQNLIEEHFNVDLLLKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z101</accession>
    <name>K9Z101_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage shock protein A, PspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217962.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0069"/>
    <dbReference type="EnsemblBacteria" id="AFZ52230">
        <property type="protein sequence ID" value="AFZ52230"/>
        <property type="gene ID" value="Cyan10605_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0069"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.71"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056466_3_2_3"/>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="28566" checksum="5D2DE1E53504919A" modified="2013-03-06" version="1">MGIFDRISRVIRANVNDMIDKAEDPEKVLEQSIREMGDDLVKMRQAVAQAIASQKRTEQQYQKNLSEANTWQQRAQLALSKGEEGLAREALVRKKTHAETAATLKAQLDSQVQQIDALRRNLTALESKISEAKTKKDMLKARISAAKANKQLQSTISNINSSSAMSAFERMEERVMLEEAEASAVGELAGMGEDSKWASLEGGTAVDDELEALKRQLSGTPEPSTALPAGNEIIDGETVSSNTPPIDDELEKLRAELRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z176</accession>
    <name>K9Z176_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0158"/>
    <dbReference type="EnsemblBacteria" id="AFZ52315">
        <property type="protein sequence ID" value="AFZ52315"/>
        <property type="gene ID" value="Cyan10605_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0158"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.164"/>
    <dbReference type="eggNOG" id="ENOG502ZBK0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088265_0_0_3"/>
    <dbReference type="OMA" id="GCVRYDV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021499">
        <property type="entry name" value="DUF3153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11353">
        <property type="entry name" value="DUF3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938630" evidence="2">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="27277" checksum="ECAC4AAAFF3BC10E" modified="2013-03-06" version="1" precursor="true">MKKIFIFLALCLCLTGCVRYDVGIQFPQANHGTMIQHIKLGEQLTNFSEKEGNAWLNSIERRALKLQGKSKRLSQDELVVTIPFSNGQDLVKKFNQFFIPTLGDKSSQKISDDNSNSLLDLSAKMSIKQNNLLFLERNTLNFDADLTPLGVVSSEGNIIISSGDLINLQIQFDFPLGAKLTTNEFAQWEKLPNNQYNIQLSAGQINQLQAVFWLPNYIGLGASAIALFIILGFYLKYQKLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B3</accession>
    <name>K9Z1B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218685.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0822"/>
    <dbReference type="EnsemblBacteria" id="AFZ52954">
        <property type="protein sequence ID" value="AFZ52954"/>
        <property type="gene ID" value="Cyan10605_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0822"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749331_0_0_3"/>
    <dbReference type="OMA" id="TIRINWN"/>
    <dbReference type="OrthoDB" id="972839at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="42786" checksum="0AEB8F13F8930DBA" modified="2013-03-06" version="1">MFKDIDKTIELGNYQEAREKLSQLIIEEKDRLWYRYYSALIAEKEGDLSLAENAYREIIKDSIYPDPTLIKLIRDGIERIVKFYQSKKEEKKQEFRTIENSQDLAVLILEPVKPEDKKNLAPQLAKLMEIDNYTATLQIPTRSLRLYKTGSLGELKYYQFELSQGGIPCFCHPIKNINKMDVYQVKFIENDGNICDLTIENDLEEEKRYTLNWAKVKSKVQGLIPIFEMTTHLDARNKVQKKQSTLDYANFFDLHVVSDNLILRFSDHFYQFEAGLTIGENSKTTQEKWKKLVNYLQRKTSDINLLSNFNLFAEGVIHFPEMLKQITAHINLFRREESVWDEAFQLYSGLIFLQTLSQQEDDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H6</accession>
    <name>K9Z1H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma 54 interacting domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0889"/>
    <dbReference type="EnsemblBacteria" id="AFZ53019">
        <property type="protein sequence ID" value="AFZ53019"/>
        <property type="gene ID" value="Cyan10605_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0889"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.934"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017386_0_0_3"/>
    <dbReference type="OMA" id="WWWPLIL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="43"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="723" mass="82619" checksum="619267C0AB4F9188" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K7</accession>
    <name>K9Z1K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl-acyl-carrier-protein synthase I</fullName>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218822.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0961"/>
    <dbReference type="EnsemblBacteria" id="AFZ53091">
        <property type="protein sequence ID" value="AFZ53091"/>
        <property type="gene ID" value="Cyan10605_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0961"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1014"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_3"/>
    <dbReference type="OMA" id="DSSDAHH"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="40608" checksum="54AE34F6A54D7DAE" modified="2013-03-06" version="1">MKIVVTGVSLFTCLGNTQDTWQKILNDVSGIKIQQPFSFLPPLPLGMIEKQPVSIHDLTKILIQQLCQDAKLTLPQDNIGVIVGSSRGCQSQWEYFLSSFAPDFSSLSWLHTLPSQPALMIAQYLQTQGFVSAPANACATGIVAIALGYELIKQNRCSQVVVGGVETAITPLTITGFNQMKALSQEGCFPFAVNRSGLVLGEGGGLLLLETEESARLRNAKIYGEILGWSMNCDALAMTTPESDGETAIRCVKDCLYNSGLCPQEIDYIHAHGTGTILNDQREALIIKKLFPHSPYVSSTKGFTGHTLGAGGAIASALNFLALEKQTLLPNTMNLTLDFELNFVKKSHHHPLKKVLCFSFGFGGQNVAIAMQNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K8</accession>
    <name>K9Z1K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218780.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0919"/>
    <dbReference type="EnsemblBacteria" id="AFZ53049">
        <property type="protein sequence ID" value="AFZ53049"/>
        <property type="gene ID" value="Cyan10605_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0919"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.966"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259687_0_0_3"/>
    <dbReference type="OMA" id="WLRLWGA"/>
    <dbReference type="OrthoDB" id="1319533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="25239" checksum="A1471ED0211A77E7" modified="2013-03-06" version="1">MTILSKILYVFPTLILLLVFSNLFWLIINPSFLPLFTLFICLYIIPLLVYRIHQYFYPNLEGISYLKGKEYNPWWGTQQIQIIYNSFSFLEKILHLVPGLFSLWLRLWGAKIGKNVYWVPTVSILDRPLIEVGDGVIIGHHTVFCSHNVKPKKDNLIVFTKKIKVGNYAFISGDVGLAPGVEIEDKAFVPYGEKLYPRVKLKANKTENDNSLSTQVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R8</accession>
    <name>K9Z1R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218256.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0380"/>
    <dbReference type="EnsemblBacteria" id="AFZ52525">
        <property type="protein sequence ID" value="AFZ52525"/>
        <property type="gene ID" value="Cyan10605_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0380"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.401"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_3"/>
    <dbReference type="OMA" id="NRDPRGH"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17902" checksum="2B5FDDEC6CAA25A4" modified="2013-03-06" version="1">MTNYINPAPTVDIIIELKDHDSRPIVLIERKNEPLGWAIPGGFMDYGESVEETAIREAKEETCLDIELLDLLYVYSDPSRDARKHTLSVVFIAEAVGQPIPADDAKNLAIFPIEKIPSNLCFDHDLILQDYLNYRLNFNSKGICFPTRPLPKIKKSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T0</accession>
    <name>K9Z1T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218271.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0396"/>
    <dbReference type="EnsemblBacteria" id="AFZ52540">
        <property type="protein sequence ID" value="AFZ52540"/>
        <property type="gene ID" value="Cyan10605_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0396"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.419"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_1_1_3"/>
    <dbReference type="OMA" id="ATTLMTQ"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="38869" checksum="6FEA480D887FB7AE" modified="2013-03-06" version="1" precursor="true">MDFAKWISFCSVIILIYIIWQVRKILLLVFTAVVFAITLNLLVEKFCKLGLKRGYGVIIATVIFLIAIALFFVIVVPSLVFQFQELLTLLPQGIDKIIFQIEKIKNNLSPEISDSFPDLEEILPQVQPIINDLLTRGFNFVSGFLGALLSGVLLIALTLMFLVEPTPYKQGFVRLFPAFYRRRITGILNRTEKDLEEWLKDTFIKIIAVSILTFIVLFILGIPLIAVQALLAGILSFTPYIGPIFSIIFPVAIAFIYSPWKPWAILIIYILIFCGVDRIIIPKLRPHRVNLIPANVIIAEVIFASFLGLLGLFLVVPLTIISQILLEEILIKDIFDHWQRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z200</accession>
    <name>K9Z200_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0268"/>
    <dbReference type="EnsemblBacteria" id="AFZ52418">
        <property type="protein sequence ID" value="AFZ52418"/>
        <property type="gene ID" value="Cyan10605_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0268"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.278"/>
    <dbReference type="eggNOG" id="ENOG5033ETN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192956_2_0_3"/>
    <dbReference type="OMA" id="FETVGYF"/>
    <dbReference type="OrthoDB" id="2058878at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="6981" checksum="117A8D6BA4C18E6D" modified="2013-03-06" version="1">MTELPIYDLVINNGLFAQMVEDPDILGQMSDAWKNFVESGQIWALLIGVFFGYIFASFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z265</accession>
    <name>K9Z265_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218955.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1102"/>
    <dbReference type="EnsemblBacteria" id="AFZ53224">
        <property type="protein sequence ID" value="AFZ53224"/>
        <property type="gene ID" value="Cyan10605_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1102"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1166"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_6_0_3"/>
    <dbReference type="OMA" id="IYERVNF"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="23023" checksum="651AFAF279551E19" modified="2013-03-06" version="1">MIAQLEKTCYSVEEYFELEETAEYKSEYHDGEIIPMTGGTTNHNKIAGNFYFYFKSAFRRQNYDIYINDVRLSIPLQRRYTYPDIMIIQDQPIYEGDKQTTITNPLIIIEVLSNSTENYDKGEKFKSYRSIKSFQEYILIDQYSFSVEQFIKESEGEWKFKEYLGENQVLKLGKIDFELSFSDIYEGVNFVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C4</accession>
    <name>K9Z2C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219023.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1173"/>
    <dbReference type="EnsemblBacteria" id="AFZ53294">
        <property type="protein sequence ID" value="AFZ53294"/>
        <property type="gene ID" value="Cyan10605_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1173"/>
    <dbReference type="eggNOG" id="ENOG502ZVZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596800_0_0_3"/>
    <dbReference type="OMA" id="WASENSN"/>
    <dbReference type="OrthoDB" id="1799145at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="523" mass="58966" checksum="1B10E7A428BD6B69" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D6</accession>
    <name>K9Z2D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218451.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0581"/>
    <dbReference type="EnsemblBacteria" id="AFZ52720">
        <property type="protein sequence ID" value="AFZ52720"/>
        <property type="gene ID" value="Cyan10605_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0581"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.613"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107036_0_0_3"/>
    <dbReference type="OMA" id="KPPHEYI"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21715" checksum="29CC758BD8079F0B" modified="2013-03-06" version="1">MFTQAEKRISLKDFLQLPETKPIKEFINGYVYEKPMPKGKHSTIQTFLTTAINQQGFINKKCCAFTELRCNFDERSIVPDISIINWEKIPKDEQGEIANIIEIAPDWIIEILSPQQSSIRVIDNILFALNHGSQIGWLIDPQERIIMTFLPNQQPQIKQNQDLLPVLSSLSHWQICPQEIFNYLTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J3</accession>
    <name>K9Z2J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218516.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0646"/>
    <dbReference type="EnsemblBacteria" id="AFZ52785">
        <property type="protein sequence ID" value="AFZ52785"/>
        <property type="gene ID" value="Cyan10605_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0646"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.682"/>
    <dbReference type="eggNOG" id="ENOG50330BX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189266_0_0_3"/>
    <dbReference type="OMA" id="RYPKYLI"/>
    <dbReference type="OrthoDB" id="2085044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008470">
        <property type="entry name" value="Uncharacterised_Ycf33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05421">
        <property type="entry name" value="DUF751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7765" checksum="D2E640D4B2C979CB" modified="2013-03-06" version="1">MDGFWENVLRYPRYMVSLILGIFFFLWQQVKPLFNNPPTAIALLGLMVGGFFFLYFTLKAMLGITPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P9</accession>
    <name>K9Z2P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ordered locus">Cyan10605_0506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218379.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0506"/>
    <dbReference type="EnsemblBacteria" id="AFZ52648">
        <property type="protein sequence ID" value="AFZ52648"/>
        <property type="gene ID" value="Cyan10605_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0506"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.536"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_4_1_3"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="20232" checksum="A760E2E64B1635BE" modified="2013-03-06" version="1">MTKIIFLGPPGSGKGTQGALIAEKHGIPHISTGDILRGAIAAQTPLGVKAKSYVDNGDLVPDELILDLIEERLGQDDAQKGWILDGFPRNVPQAEFLTGLLKKLDQNCDAVVNLDVPNEVILQRLLARGRKDDNEETINNRLDVYRQQTAPLIDYYQQSNLLKTVDGDRSMEEITAEITTIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U0</accession>
    <name>K9Z2U0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0912"/>
    <dbReference type="EnsemblBacteria" id="AFZ53042">
        <property type="protein sequence ID" value="AFZ53042"/>
        <property type="gene ID" value="Cyan10605_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0912"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.959"/>
    <dbReference type="eggNOG" id="ENOG502Z8UT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088154_0_0_3"/>
    <dbReference type="OMA" id="WFLICKG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="253" mass="29505" checksum="B82DC2D83100CE38" modified="2013-03-06" version="1">MSIEKILLPVEELHSEKDEMFSLFKTHFEGVNRQQFEEDLSGKDWVILLKENLVLKGFTTINFYDAKFHNKPVRIVYSGDTITDPSMWSSPALAKAWVASVKAIHQERKEKLYWLLISSGFRTYRFLSIFWKTFYPCYAQNTPPEIAEFMHNLAQEKFGEYYDVSTGIVRFSQPQILKPHLQEIPDERLKNSHIAFFLRKNPSHNEGDELVCLAEVSETHLTKAGLRIWRSSDSIHIPFSINKQNSDDTTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U2</accession>
    <name>K9Z2U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218404.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0531"/>
    <dbReference type="EnsemblBacteria" id="AFZ52673">
        <property type="protein sequence ID" value="AFZ52673"/>
        <property type="gene ID" value="Cyan10605_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0531"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.562"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075760_0_0_3"/>
    <dbReference type="OMA" id="DFPEWTR"/>
    <dbReference type="OrthoDB" id="1626945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="30502" checksum="6B8D5EE3ACC5119E" modified="2013-03-06" version="1">MNGKVIDSGANSIPLVLLPLAFIIIIVFVAWPLLVAIFIFALGLKLWERFRLQQLSEEIDPYFNNLIQAHQGCVTVLDLTNKTELKSKTARWYLDQKAEEYGAVKRQYEDKGIVYYFLTASTLGSILDDSEPDDSDTDEDINIASSSQQSSSSYSSISPASSPTPEVKLESVTITPPENSSSSPPPVNDDSVSNTSPEVETSTQEEDTSNNLDNQEENGMSLNQSDLAKRLEVHPSTVGKRKSDRDFGLWSQSRDPDGIPWQYIEDTKMFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W5</accession>
    <name>K9Z2W5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apolipoprotein A1/A4/E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219228.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1386"/>
    <dbReference type="EnsemblBacteria" id="AFZ53499">
        <property type="protein sequence ID" value="AFZ53499"/>
        <property type="gene ID" value="Cyan10605_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1386"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080678_0_0_3"/>
    <dbReference type="OMA" id="ISRINDM"/>
    <dbReference type="OrthoDB" id="1641918at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="33209" checksum="2AE77D8630C09D60" modified="2013-03-06" version="1">MAVDLEQSIAETVTQLQELLNRADEAEENLNQARERLAEVSQQFDSNWDELSTRADGLLERISNARDELNGETENLRQGISDLQTNLQSAQDEANQMVEDTKTEITALGEDSDTKSSEFEEVFNSVKEALETLQTKVEEVQQDLEETVSESQSKLENDFNSALSSNEEEIEVRAGEMEQEIAQDAISRINDMIGNLTTQLQEITASVREKAEEEANNTQESANSALDEFTGNAEGMFEDLLSTAEDIEDALTTLSELVTDLGGTVDTTKDTLMTAMDTTNIGLNTALGVFEEVQELLGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z3</accession>
    <name>K9Z2Z3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HerA-ATP synthase, barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219310.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1470"/>
    <dbReference type="EnsemblBacteria" id="AFZ53581">
        <property type="protein sequence ID" value="AFZ53581"/>
        <property type="gene ID" value="Cyan10605_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1470"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1559"/>
    <dbReference type="eggNOG" id="ENOG502Z832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112459_0_0_3"/>
    <dbReference type="OMA" id="IHQAVYR"/>
    <dbReference type="OrthoDB" id="1865257at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAS-barrel" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="223" mass="25279" checksum="D8C33B423324045F" modified="2013-03-06" version="1">MRLPLPKQERENPLSEHIGEVIETSTTEFLAQCLEPEELNFPTMPPFGSWVKSLDEESGNKIFAVVTNVTTAPVDSVHKARALGLTLAELREQQPQIFAMLRTEFRAVIIGFETPATNDNNGYSPSNGNIYQYLPPRPPQIHQGVFRCVPDEVIKFTANPDFLRVLLQVQNTPVESLIAATLRESYRLRNGDRTWLVNAGRTLSVLLKNDYDCLKYILSQVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z300</accession>
    <name>K9Z300_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218454.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0584"/>
    <dbReference type="EnsemblBacteria" id="AFZ52723">
        <property type="protein sequence ID" value="AFZ52723"/>
        <property type="gene ID" value="Cyan10605_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0584"/>
    <dbReference type="eggNOG" id="ENOG5032SZ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432698_0_0_3"/>
    <dbReference type="OMA" id="QYLLWGE"/>
    <dbReference type="OrthoDB" id="1849899at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023815">
        <property type="entry name" value="CRISPR-assoc_A791736"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03984">
        <property type="entry name" value="TIGR03984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="190" mass="21800" checksum="4B113217131E19A5" modified="2013-03-06" version="1">MTTFLHAQSSVNITLSEAINQCLNQLEDAIALLYSPNSCQVLKLEKDGNLSNSKGEIINTNYQDNYIFEARIFNQNYELRWLNEDEGKGTAVIISENDFDNCLAKKLDSIEVIDTIKQQYLLWGEKAKTTLNEGWQRLSASRIGSLDIPLSQSLSQEKRVYLNTREYLKVMDNFGNVRVIEERLINLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z320</accession>
    <name>K9Z320_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219283.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1443"/>
    <dbReference type="EnsemblBacteria" id="AFZ53554">
        <property type="protein sequence ID" value="AFZ53554"/>
        <property type="gene ID" value="Cyan10605_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1443"/>
    <dbReference type="eggNOG" id="ENOG502ZWQM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591783_0_0_3"/>
    <dbReference type="OrthoDB" id="2232378at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="20090" checksum="51BA932610293795" modified="2013-03-06" version="1">MIKETNYLKKENRLPLKLHTAVGDATRIAIIHREFYKHKEKYIHLIQEYLSHSYLENNPVEKYYKKEGSKKSILQNIPLNLEQIKRIKEGILLLLSLDKLTEEEKQLEEDFIKKNKNYLLVKKLEENNYYLANFTTELLKINRFLNLNFNISLKDLYEIDFSQLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A6</accession>
    <name>K9Z3A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218806.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0945"/>
    <dbReference type="EnsemblBacteria" id="AFZ53075">
        <property type="protein sequence ID" value="AFZ53075"/>
        <property type="gene ID" value="Cyan10605_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0945"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.996"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_3"/>
    <dbReference type="OMA" id="DHPHADT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="15996" checksum="4DBDE68886110035" modified="2013-03-06" version="1">MVISKDNIIKTLKSKGLRVTPQRFAVYSNLLHRCDHPTAEQILTDLNQEVPTLSQATVYLSLQTLQNVGLVKEVLLEEGVCRYDANVDPHHHFLCECCGEIEDIPWESLTGINISNLRQGLKVDRFEVTVYGRCDRCSDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E3</accession>
    <name>K9Z3E3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="9" type="synonym">atpC</name>
        <name evidence="10" type="ordered locus">Cyan10605_0765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218629.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0765"/>
    <dbReference type="EnsemblBacteria" id="AFZ52898">
        <property type="protein sequence ID" value="AFZ52898"/>
        <property type="gene ID" value="Cyan10605_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0765"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.805"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_0_3"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="315" mass="35273" checksum="A6D4283D4AF3B5A3" modified="2013-03-06" version="1">MSNLKAIRDRIDSVKNTKKITEAMRLVAAAKVRRAQEQVTATRPFADTLAQVLYGLQNRLRFEDVDLPLLKEREVNTVALLVVTGDRGLCGSYNASIIKRAEQRAAELKSQGINYTYITVGRKAEQYFKRREEPISSTFYGLEQIPTAQDSQAIADELISLFFSNVVDRVELIYTRFVSLISSKPVIQTLLPLTPQGLEVHDDEIFRLTVRGGNFQVERESVTTPVADFPRDMIFEQDPVQILDSLLPLYINNQLLRALQESAASELAARMTAMNNASDNASDLMKTLTLSYNKARQASITQQILEVVAGANSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F3</accession>
    <name>K9Z3F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218639.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0775"/>
    <dbReference type="EnsemblBacteria" id="AFZ52908">
        <property type="protein sequence ID" value="AFZ52908"/>
        <property type="gene ID" value="Cyan10605_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0775"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.816"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_0_1_3"/>
    <dbReference type="OMA" id="YGLTIMM"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="16410" checksum="7D50C6D9141D06DE" modified="2013-03-06" version="1">MKLTTKAHYAVKALLDLSLSPLNQPISVNKIADRQHIPAPYLEKILIQIRRAGLIKSVRGSQGGYQLAMSPEKISLGEILTAVGDKIEPLPDLDNTANSPEDWVTITLWKRLNRKLKEAIFEISLADLYYDARSRQADLGEGNNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F6</accession>
    <name>K9Z3F6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0996"/>
    <dbReference type="EnsemblBacteria" id="AFZ53125">
        <property type="protein sequence ID" value="AFZ53125"/>
        <property type="gene ID" value="Cyan10605_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0996"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1053"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_3"/>
    <dbReference type="OMA" id="NRQYRIR"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="5">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="143"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="518" mass="56747" checksum="0D6FD6195F7D09B6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G2</accession>
    <name>K9Z3G2_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0785"/>
    <dbReference type="EnsemblBacteria" id="AFZ52918">
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        <property type="gene ID" value="Cyan10605_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0785"/>
    <dbReference type="eggNOG" id="ENOG5032TD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112039_2_0_3"/>
    <dbReference type="OMA" id="TIYVPVY"/>
    <dbReference type="OrthoDB" id="1716865at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021471">
        <property type="entry name" value="DUF3124"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11322">
        <property type="entry name" value="DUF3124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939087" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20813" checksum="D660FDBDCBF84CF8" modified="2013-03-06" version="1" precursor="true">MVWKIKHLILLFISFFIISCQAEETDNLELTKEPFINTEIVTIDDNFKPIMGEIIYVPAYSYIYYSNRQRSHSLAITLSLHNTDVELPIMIKSVKYYDSKGQLLEDYLSHPIQLNALSSTNFYIEDDDTRGGVGGNFLIEWVAQKEVSSPIAESVMVSTASTQGISFVSTGRIIKKLKFDDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I0</accession>
    <name>K9Z3I0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219406.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1570"/>
    <dbReference type="EnsemblBacteria" id="AFZ53679">
        <property type="protein sequence ID" value="AFZ53679"/>
        <property type="gene ID" value="Cyan10605_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1570"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129283_1_0_3"/>
    <dbReference type="OMA" id="HELHETM"/>
    <dbReference type="OrthoDB" id="1919052at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="15105" checksum="8D29ACBC38717E0F" modified="2013-03-06" version="1">MFGNQANFAPAEAFTIIILFSAISDGSFEDEEKDIILNILKRMKTFRYYGGNIVQLMSNCLKYLLKDPIQALAQSVISLPQELHETVFVVATDIIMSDGKVTEKEAATLDMLAKYLSISPTQVTKIIEVIAIKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T4</accession>
    <name>K9Z3T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1292"/>
    <dbReference type="EnsemblBacteria" id="AFZ53407">
        <property type="protein sequence ID" value="AFZ53407"/>
        <property type="gene ID" value="Cyan10605_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1292"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1365"/>
    <dbReference type="eggNOG" id="COG4264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018283_0_0_3"/>
    <dbReference type="OMA" id="TGWHRFG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="150"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="428"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="616" mass="70875" checksum="F9963E2BE2206FD5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T8</accession>
    <name>K9Z3T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218779.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0918"/>
    <dbReference type="EnsemblBacteria" id="AFZ53048">
        <property type="protein sequence ID" value="AFZ53048"/>
        <property type="gene ID" value="Cyan10605_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0918"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.965"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093323_0_0_3"/>
    <dbReference type="OMA" id="TSRNTLW"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="247" mass="29092" checksum="433E11AD59209606" modified="2013-03-06" version="1">MFPIIIFWLFFATTLLQSKQRKLLITKSLQDWFLDGIGLCFQGAIIPLLQIGIATHLYQKILPQSQGCLIIEPWLGFIISFVIVDYIYYWTHRLLFHEILFSVHAVHHSVTQMDMLGTSRNTLWSSLFLPYIWLNSLMLYLLSDYRGYAFGFLLTCLLDLWRHSSWNLPENNIIHRILNPWLILPQDHAHHHCGDKLGNFAANLKLWDIFHGTYIKPNYHDENMGITLNINIVQKLFFPFTPFNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V3</accession>
    <name>K9Z3V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihem cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1711"/>
    <dbReference type="EnsemblBacteria" id="AFZ53814">
        <property type="protein sequence ID" value="AFZ53814"/>
        <property type="gene ID" value="Cyan10605_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1711"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1818"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123240_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018588">
        <property type="entry name" value="Dihaem_cytochrome-c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09626">
        <property type="entry name" value="DHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="21492" checksum="B84E721362F5D3F8" modified="2013-03-06" version="1" precursor="true">MPPERGGDNCQLFILRGIMFFRSKKRKKVTLPLILALIVLFCSIFGWGASLAMNHQSLTAGTKSVDKAVGNFVIGKDLYLENCSTCHIPIPPAVLPSETWQTILENPGNHYGVRIDGIVRFTQVLMWQYLQQYSRQLLKDEPRPKFIAQSRYFFALHPDIKFTTPVTHNTCIECHNRAIEFDYSVTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X1</accession>
    <name>K9Z3X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219171.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1327"/>
    <dbReference type="EnsemblBacteria" id="AFZ53442">
        <property type="protein sequence ID" value="AFZ53442"/>
        <property type="gene ID" value="Cyan10605_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1327"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1401"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_1_1_3"/>
    <dbReference type="OMA" id="MYIQLGM"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10584" checksum="6B88B7E0EDA71A34" modified="2013-03-06" version="1">MDLEFEWNDSKAKTNKRKHGVSFEEASSVFNDPLSINFDDPDHSQTENRYIIIGLSSQGRCLFVSFVERGKKIRLISARLVTPKERRFYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X8</accession>
    <name>K9Z3X8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219566.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1736"/>
    <dbReference type="EnsemblBacteria" id="AFZ53839">
        <property type="protein sequence ID" value="AFZ53839"/>
        <property type="gene ID" value="Cyan10605_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1736"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1843"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_0_1_3"/>
    <dbReference type="OMA" id="PNQLDCL"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938579" evidence="2">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="36"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33317" checksum="A359E3660B75A09E" modified="2013-03-06" version="1" precursor="true">MWKKLLNIGVAFTCLGLCSSPVLAGTVLERIKETGVIRAGYRDDTPPFAFRNEQGKPVGYSVDILELIQAEAQKQLNTPVTLEFVRINPSNRFEQIQDGSIDIECGSTTVTWEREKFVDFTVSYFASGTQMIVNRGSGFANSDNLTGAKVGVIPNTTNEKAMKIYASSATLVPVKSEEEGWAMLQKGDLDGFAGDGILLQALKKQSDNGQDYEIVPEFPYMIESYACTVPEDESQWRGLVNKAIVKFMQGVTTDTPSAIDIYERWFGQNGNTPYPIETMADYFQGIINGYEWIIIDERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z3</accession>
    <name>K9Z3Z3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Prephenate dehydratase</fullName>
            <shortName evidence="9">PDT</shortName>
            <ecNumber evidence="3 9">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="12" type="ordered locus">Cyan10605_1348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219191.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1348"/>
    <dbReference type="EnsemblBacteria" id="AFZ53462">
        <property type="protein sequence ID" value="AFZ53462"/>
        <property type="gene ID" value="Cyan10605_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1348"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1422"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_2_3"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="32246" checksum="4831660ADB370C86" modified="2013-03-06" version="1">MTKIIAYLGPEGTYSEVATLYYSRLLKEIHSIESELIPIPSISQTLHALAQGKADIAVVPIENSIEGTVAITLDTLWQLDGLYIRKGLTIPIIHNLLSRGRSLKGIKTIYSHPQALAQCQKWLEKNLPQARLIPTNSTTEALHHLNQEPTAGAISSSRAAQLYDLPIKAKNINDYPDNCTRFWVVDRIGKTRGNHVSVGFAFEANIPGVLVKPLEIFAQKQINLTKIESRPTKRCLGEYLFFLDLQGDSDGKPIQEALKELEKVTKTVKILGSYDVEKVDLNQLYSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z433</accession>
    <name>K9Z433_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1216"/>
    <dbReference type="EnsemblBacteria" id="AFZ53335">
        <property type="protein sequence ID" value="AFZ53335"/>
        <property type="gene ID" value="Cyan10605_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1216"/>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107928_1_0_3"/>
    <dbReference type="OMA" id="KLRSDQT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="12493" checksum="7DFBFE85CED13E90" modified="2013-03-06" version="1">MRKNMTPAERKLWSEYLRRLTYKFMKQRPIDNFIVDFYCSQKRLVIEVDGDSHFQPEGIERDLTRTAILENYRLRLLRFSNDDVLRNFEGVCGAIGFELDSLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z468</accession>
    <name>K9Z468_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219266.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1426"/>
    <dbReference type="EnsemblBacteria" id="AFZ53537">
        <property type="protein sequence ID" value="AFZ53537"/>
        <property type="gene ID" value="Cyan10605_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1426"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1507"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="NGWEFRA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17688" checksum="A1F6FF51FA6F178E" modified="2013-03-06" version="1">MSNLDLVNPEESVILIVDDLKQNLKLLNIILESAHYQTSLALSGKDALERLKVLNPDLILLDLMMPDISGLEVCRRIKSNPEYEDIPVIFLTASVEENHLIEAYSLGANDYVNKPFRKPELLARIKTQLTLRKQSKLIQELLEKIESLQNSQHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z477</accession>
    <name>K9Z477_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tic22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219276.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1436"/>
    <dbReference type="EnsemblBacteria" id="AFZ53547">
        <property type="protein sequence ID" value="AFZ53547"/>
        <property type="gene ID" value="Cyan10605_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1436"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1519"/>
    <dbReference type="eggNOG" id="ENOG502Z8C3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073560_0_0_3"/>
    <dbReference type="OMA" id="HIQDVVK"/>
    <dbReference type="OrthoDB" id="1319693at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PTHR33926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04278">
        <property type="entry name" value="Tic22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="26962" checksum="F3FC42741EDA89BF" modified="2013-03-06" version="1">MLEQQSLLNKIKKLTVIGATVASCWLTQTTRILALPQEVILEKLKPIPVFTIADSQGAPLIASTEDNNRVAGVFISEKDANSFVERLKQDNPDLGKQVQVVPVSLAEVYQLSEKNSQQQDGVQFAYVPSSQQIEQAQQLNNQYQGGVPLFVAKAGEDQGYLTIKQNDQEVIPFFFEKQQVQQLVENFKKAQPDLANSVQIEVVILEGMLDAMKQGDDEMLTRIVLWPSKESLEFLRSNTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J3</accession>
    <name>K9Z4J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1964"/>
    <dbReference type="EnsemblBacteria" id="AFZ54059">
        <property type="protein sequence ID" value="AFZ54059"/>
        <property type="gene ID" value="Cyan10605_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1964"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2085"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120816_0_0_3"/>
    <dbReference type="OMA" id="RNDVEDQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="175" mass="20767" checksum="32AA42567A22BC3C" modified="2013-03-06" version="1">MNSINLWKNIFSSQKNQPEKDGLIITKTQRDKLLSENQNLLKEKTKLQQLVKIQQQESEAKEEALYSELLDIFDSLEFLIDYLDNNLQEENFNPKAFKRLPKFVNTMQEKLLTILSRREVERIDFDEDTPDFSVCKVVDREIRDDIPEQTITKIVRQGFKIKEKILRYVEVITAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q8</accession>
    <name>K9Z4Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase DndC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219891.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2077"/>
    <dbReference type="REBASE" id="329008">
        <property type="entry name" value="M.Cap10605DndCP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54166">
        <property type="protein sequence ID" value="AFZ54166"/>
        <property type="gene ID" value="Cyan10605_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2077"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2207"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027799_2_1_3"/>
    <dbReference type="OMA" id="GDSRFGC"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017598">
        <property type="entry name" value="SulphurTrfase_DndC_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03183">
        <property type="entry name" value="DNA_S_dndC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="513" mass="59972" checksum="2EEEC408EF9BF502" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S0</accession>
    <name>K9Z4S0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ordered locus">Cyan10605_1604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219439.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1604"/>
    <dbReference type="EnsemblBacteria" id="AFZ53712">
        <property type="protein sequence ID" value="AFZ53712"/>
        <property type="gene ID" value="Cyan10605_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1604"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1703"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_3"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="19651" checksum="21305C0A17B7EDFD" modified="2013-03-06" version="1">MSEINPEIGIIMGSDSDLPTMKGAIAVCEQFNIKYEVAIVSAHRTPEKMVKYAQNAHKRGIKVIIAGAGGAAHLPGMVASLTPLPVVGVPVTTRQLQGVDSLYSIVQMPRGIPVATVAIGNAENAGLLAIRILASQQPDLLEKVLKYSNNLRQMVEDKQTQLDKIGYEKYLESMKPEFGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V3</accession>
    <name>K9Z4V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219916.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2102"/>
    <dbReference type="EnsemblBacteria" id="AFZ54191">
        <property type="protein sequence ID" value="AFZ54191"/>
        <property type="gene ID" value="Cyan10605_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2102"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2234"/>
    <dbReference type="eggNOG" id="COG3788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_3_1_3"/>
    <dbReference type="OMA" id="YARHKYF"/>
    <dbReference type="OrthoDB" id="1899954at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="SSF161084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="14744" checksum="B37DE424D02C11AB" modified="2013-03-06" version="1" precursor="true">MLLGASLITVSALLVYFVTIINVGRARAKYKVMPPAMTGDENFERALRVQQNMLEQLVLFLPIMWIFSYYVSELWGAIIGGVWILGRVLYAWGYYQEAKKRMVGFGISSLSIMALLLTCLYSLTMALVGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y1</accession>
    <name>K9Z4Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219951.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2138"/>
    <dbReference type="EnsemblBacteria" id="AFZ54226">
        <property type="protein sequence ID" value="AFZ54226"/>
        <property type="gene ID" value="Cyan10605_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2138"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2273"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_9_0_3"/>
    <dbReference type="OMA" id="WDKQVHQ"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="16823" checksum="2568C88A4A18B13D" modified="2013-03-06" version="1">MNKTVGEVMTPNPITVKPETPLKEAIALLVEHKISGMPVIKEGGELVGILSESDLMWQETGVEPPPYIMILDSIIYLQNPNRYDKEIHKALGQTVADVMSDKPITISSTKTIKEAAQLLHQKQIRRLPVVDSDKKIIGILTQGDIIRAMADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z543</accession>
    <name>K9Z543_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase</fullName>
            <shortName evidence="6">Mg-protoporphyrin IX monomethyl ester oxidative cyclase</shortName>
            <ecNumber evidence="6">1.14.13.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acsF</name>
        <name evidence="8" type="ordered locus">Cyan10605_1422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58632"/>
            <dbReference type="ChEBI" id="CHEBI:60491"/>
            <dbReference type="EC" id="1.14.13.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AcsF family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.81" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219262.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1422"/>
    <dbReference type="EnsemblBacteria" id="AFZ53533">
        <property type="protein sequence ID" value="AFZ53533"/>
        <property type="gene ID" value="Cyan10605_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1422"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1503"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048037_0_0_3"/>
    <dbReference type="OMA" id="ENRHGDC"/>
    <dbReference type="OrthoDB" id="366541at2"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048529">
        <property type="term" value="F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036068">
        <property type="term" value="P:light-independent chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01047">
        <property type="entry name" value="ACSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01840">
        <property type="entry name" value="AcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008434">
        <property type="entry name" value="AcsF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31053">
        <property type="entry name" value="PTHR31053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02029">
        <property type="entry name" value="AcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="7">
        <location>
            <begin position="84"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="353" mass="41953" checksum="8FD5D155A35FE8A2" modified="2013-03-06" version="1">MTATAIKPKSDKKKELKETLLTPRFYTTDFKAIAEMDISAQEKELRAMLQEMKNDYNRNHFVRDEEFEQTWDHLDEQTRSAFIDFLERSCTSEFSGFILFKEISRRIKDKNPLLSEIFSLMARDEARHAGFLNKAMSDFNISLDLGYLTKNRVYTFFKPEWVIYAVYLSEKIGYWRYILMYRHLEKNPQYKFYPLFKKFEHWCQDESRHGDIFNALLRSQFSMWQGWQAKLWSKFFLLSVFATHTLTVHEREDFYESVGLDAKEYDRQVIEKTNNTAAKAFPVILDTNHPKFFAGLEKCSEYNLQMSKIDESNQPNFIKALRKLPLQIAIFFNLLGLYFIKSINAEELRGAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E6</accession>
    <name>K9Z5E6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ordered locus">Cyan10605_1513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219350.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1513"/>
    <dbReference type="EnsemblBacteria" id="AFZ53623">
        <property type="protein sequence ID" value="AFZ53623"/>
        <property type="gene ID" value="Cyan10605_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1513"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1606"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_3"/>
    <dbReference type="OMA" id="VDLTIYV"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="21452" checksum="9F50CD8544598326" modified="2013-03-06" version="1">MTFRIGIAGPVGSGKTALLDALCKNMREKYSLAAVTNDIYTQEDAQFLVRSQSLTPDRIKGVETGGCPHTAIREDASINIEAIEELETTFKDLDIVFVESGGDNLAATFSPELVDLTIYVIDVSAGDKIPRKGGPGITKSDLLVINKIDLAPHVGASLEVMTRDSQKMRGDKPFIFTNLKTGEGLEKVIDFIQFHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E9</accession>
    <name>K9Z5E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220093.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2285"/>
    <dbReference type="EnsemblBacteria" id="AFZ54369">
        <property type="protein sequence ID" value="AFZ54369"/>
        <property type="gene ID" value="Cyan10605_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2285"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2427"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723031_0_0_3"/>
    <dbReference type="OMA" id="VMPIPHT"/>
    <dbReference type="OrthoDB" id="994662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="44423" checksum="092F5032B40E0637" modified="2013-03-06" version="1">MINSQTKNNPLFISLIPNLMGGEGHIIPYHQSITKAMNILGWHHEVIYSTEDNLPSLPSHWQGCVKGNQLEEKANIFQTIKDVDLFAKTIKIFLEQRLISNSNQPIIIFVERFIHLQLFSLLLAINNLPKDNLYIWVLYRHNFHQHKTKGIYKLLNKLLKKSVKKDHFHLFSDSELLANSMEKYFNESFTVMPIPHTEFVDKNRDLENNSIICWWAGPPREEKGWQVIRSLADYPIKNGDNFVLVTAKSADLISINGGVKVITTDDNLSRLDYIHWLQKTDIMLIPYDAIAYQERTSGVFTEAVMAGNIPLTTTNTWMARELLKFGLDNLIISWENPESVWQHIEKVFHCQETRCKLKKMQESYRNIHNIHNFAHQFLISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M6</accession>
    <name>K9Z5M6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="9">RNAP subunit beta'</shortName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoC2</name>
        <name evidence="12" type="ordered locus">Cyan10605_1569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 Zn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">In cyanobacteria the RNAP catalytic core is composed of 2 alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219405.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1569"/>
    <dbReference type="EnsemblBacteria" id="AFZ53678">
        <property type="protein sequence ID" value="AFZ53678"/>
        <property type="gene ID" value="Cyan10605_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1569"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1666"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_1_0_3"/>
    <dbReference type="OMA" id="IEGKSDW"/>
    <dbReference type="OrthoDB" id="4373at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01324">
        <property type="entry name" value="RNApol_bact_RpoC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012756">
        <property type="entry name" value="DNA-dir_RpoC2_beta_pp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02388">
        <property type="entry name" value="rpoC2_cyan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_4" evidence="11">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb1_5" evidence="10">
        <location>
            <begin position="176"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1279" mass="141319" checksum="06269219E24F5B5D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z2</accession>
    <name>K9Z5Z2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin thioredoxin reductase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219530.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1700"/>
    <dbReference type="EnsemblBacteria" id="AFZ53803">
        <property type="protein sequence ID" value="AFZ53803"/>
        <property type="gene ID" value="Cyan10605_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1700"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1806"/>
    <dbReference type="eggNOG" id="ENOG5032ZFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171349_0_0_3"/>
    <dbReference type="OMA" id="YHHPEHR"/>
    <dbReference type="OrthoDB" id="1984752at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004207">
        <property type="entry name" value="Fd_thioredoxin_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044166">
        <property type="entry name" value="FTRV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46937">
        <property type="entry name" value="PTHR46937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02941">
        <property type="entry name" value="FeThRed_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeThRed_A" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8806" checksum="C68AE3D54E3047FC" modified="2013-03-06" version="1">MKIGDRVKVKESVIVYHHPEHKKEPFDIKGMEGELIKIVTEWQGRPVSANFPYLVQFSKKFKAHLREEEITIVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z615</accession>
    <name>K9Z615_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219560.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1730"/>
    <dbReference type="EnsemblBacteria" id="AFZ53833">
        <property type="protein sequence ID" value="AFZ53833"/>
        <property type="gene ID" value="Cyan10605_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1730"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1837"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133730_1_0_3"/>
    <dbReference type="OMA" id="ISHIDYW"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="15316" checksum="0CC233A05FFE3C0D" modified="2013-03-06" version="1">MNLIDIIKEDYQKFPEDQTYAIYAENVHFKDPVYDFYGLKKYQEMIAFLRKWFSNLNLELHEINQIENQINTRWTMSWNSPLPWKPFISVSGRSELKLKDDLIVGHYDYWDCSFFDMIKQHFIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z638</accession>
    <name>K9Z638_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220332.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2528"/>
    <dbReference type="EnsemblBacteria" id="AFZ54609">
        <property type="protein sequence ID" value="AFZ54609"/>
        <property type="gene ID" value="Cyan10605_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2528"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2682"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_3"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="676" mass="77505" checksum="F2B29509DF922F4A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B3</accession>
    <name>K9Z6B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219675.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1846"/>
    <dbReference type="EnsemblBacteria" id="AFZ53948">
        <property type="protein sequence ID" value="AFZ53948"/>
        <property type="gene ID" value="Cyan10605_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1846"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057011_4_4_3"/>
    <dbReference type="OMA" id="DYKMAVC"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="4">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="29268" checksum="97FCB88B209346F7" modified="2013-03-06" version="1">MTFWDLQSWQKISILPFSLFPYDVHLFYGNVSNFLDFIPFFKSLLSDDELNKALYFKSQERCNSYLVNKGILRVILANYLLIKPEEIFFFYNKKGKPVLDFSINNIGLNFNLSHSKTDIIYCFSLLNLGVDLEELEDNNNLLRIAKRFFAQEEYQYLQHLKKEEQVKTFYQFWTKKEAYLKAIGEGLSGGLNTINFCTNSYSQWQINNFSLDDNFVGAIAVNAQYKCNYYSLELLPEILEQLILNLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F3</accession>
    <name>K9Z6F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219880.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2066"/>
    <dbReference type="EnsemblBacteria" id="AFZ54155">
        <property type="protein sequence ID" value="AFZ54155"/>
        <property type="gene ID" value="Cyan10605_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2066"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2195"/>
    <dbReference type="eggNOG" id="COG3651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_3"/>
    <dbReference type="OMA" id="TGWFRDG"/>
    <dbReference type="OrthoDB" id="1635990at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="13516" checksum="77CCB3EC7C5B176F" modified="2013-03-06" version="1">MTNSRNVYGKPLKTCCTSPMTGFYRSGCCDTGLEDRGLHTVCAQVTEEFLLYSKKQGNDLITPVSMFNFPGLKAGDKWCLCVSRWVEALKAGFAPPIILEATHEKTLEFVPLEILQEYSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F9</accession>
    <name>K9Z6F9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220427.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2630"/>
    <dbReference type="EnsemblBacteria" id="AFZ54704">
        <property type="protein sequence ID" value="AFZ54704"/>
        <property type="gene ID" value="Cyan10605_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2630"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2794"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_3"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="307"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="581" mass="65500" checksum="5FD519A57C807B05" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J0</accession>
    <name>K9Z6J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHP02436-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220467.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2670"/>
    <dbReference type="EnsemblBacteria" id="AFZ54744">
        <property type="protein sequence ID" value="AFZ54744"/>
        <property type="gene ID" value="Cyan10605_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2670"/>
    <dbReference type="eggNOG" id="ENOG5032RWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_2_0_3"/>
    <dbReference type="OMA" id="KMSIAYK"/>
    <dbReference type="OrthoDB" id="1986697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035652">
        <property type="entry name" value="CHP02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13967" checksum="27CD2D46B23428A6" modified="2013-03-06" version="1">MNSIIYQKAYKFSLRIIKAYKYLIEEKKEFILSKQLLRSGTSIGANIAEANGAISKADFRHKMSIAYKESLETQYWLSLLKDSEVIDVKSYQSIYQDVVEISKILCSIVKNTKAKNNKSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K3</accession>
    <name>K9Z6K3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein Cyan10605_1937</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219758.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1937"/>
    <dbReference type="EnsemblBacteria" id="AFZ54033">
        <property type="protein sequence ID" value="AFZ54033"/>
        <property type="gene ID" value="Cyan10605_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1937"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_3_0_3"/>
    <dbReference type="OMA" id="RWRCRWG"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16848" checksum="171858C431E99D7B" modified="2013-03-06" version="1">MKKIGSLGEKIIAQWLINKGYSVIESNWHCRWGEIDLIVINKSLKEIIFVEVKTRSIKNWDDNGLYSINNKKQEKLWLTASLFLEKNQIFTDWNCRFDIALLTYKKLTNFGTVFSVNDNCLRPKFNYEGYQFEMVDYLENAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P5</accession>
    <name>K9Z6P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220527.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2732"/>
    <dbReference type="EnsemblBacteria" id="AFZ54804">
        <property type="protein sequence ID" value="AFZ54804"/>
        <property type="gene ID" value="Cyan10605_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2732"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2898"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041001_0_0_3"/>
    <dbReference type="OMA" id="QLHICYC"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="381" mass="43244" checksum="209DC23DCF4FFFB2" modified="2013-03-06" version="1">MKIALVHEWLTPKATGGSELVVKEILQFIDAQVFALIDFESVNPHSYLYQREIKTTFLQHFPFSGNGVQKYLPLLPLAIEQLNLTEYDVVLSSSHAVAKGVITRPDQPHICYCHTPMRYAWDLTFDYLDRTPAGKGIQGIFTRYLLHQLRQWDVISANRVDFFIANSHHTARRIWRCYRRQAKVIYPPVQVSQFPFKAEKSDYYLTVSRLVSYKKVSMIVEAFNRNGLPLVVIGEGAEMDYIRAIAKPNITLLGSVNDKTLKEYMSNAKAFIYAACEDFGIAIVEAQACGTPVIAYGGGGALETVIDMRENSQQGTGILFSPQTVEGLLEGVKTFTILEKEFKPENARIQAEKFSAETFKQDYLAFFDQCCQNFALIRFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T5</accession>
    <name>K9Z6T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, WecB/TagA/CpsF family</fullName>
            <ecNumber evidence="1">2.4.1.187</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.187" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219995.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2184"/>
    <dbReference type="EnsemblBacteria" id="AFZ54270">
        <property type="protein sequence ID" value="AFZ54270"/>
        <property type="gene ID" value="Cyan10605_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2184"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2320"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_3"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="26637" checksum="530CF6649CD4DA09" modified="2013-03-06" version="1">MKTFPVLGLPIHLSENYQDLLISRVENNTPTHVVTMNSEMAMMAQKNTDLATAINKADLVVPDGSGVIFYLKRRGQKQQRIAGIELAASLIEAIGKKGKDYPICFYGGAKGVSEKAAQAWKEKVTSAHIIYNHGYLSGQELDDWCETIKKVQPKLILVGLGVPRQELWIMNHRHLAPNAVWIGVGGSFDIWGGVKERAPEFFCNNHLEWLYRLYQEPSRWRRMLALPRFFIKAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V5</accession>
    <name>K9Z6V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multisubunit sodium/proton antiporter, MrpG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220015.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2204"/>
    <dbReference type="EnsemblBacteria" id="AFZ54290">
        <property type="protein sequence ID" value="AFZ54290"/>
        <property type="gene ID" value="Cyan10605_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2204"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2342"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174640_0_0_3"/>
    <dbReference type="OMA" id="GYVLAYC"/>
    <dbReference type="OrthoDB" id="1908747at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10638" checksum="9E18A7ACA17963FA" modified="2013-03-06" version="1" precursor="true">MDFLTYFFMVIGLVFWLWGTIQILDKRSVLYKLHSLSVADTLGSILIVFALALKIPSELPLLILAIISLTLWNTMLGYVLAYCSRNQEGKKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z6</accession>
    <name>K9Z6Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220060.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2249"/>
    <dbReference type="EnsemblBacteria" id="AFZ54335">
        <property type="protein sequence ID" value="AFZ54335"/>
        <property type="gene ID" value="Cyan10605_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2249"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2390"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_3"/>
    <dbReference type="OMA" id="YERYSLW"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="394" mass="44146" checksum="303ED601EFA269F3" modified="2013-03-06" version="1">MKVAYVCADVGIPVFGQKGCAIHVQEIIRSFLAKNIEISLFTPRLGEKKPCDFEKINIYPLPPIPKVEKGEREKIALSINSDLDSLLTLTQPFDFIYERYSLWSYAGVEFAQKRGIPSILEVNAPLIIEQDRHRGLVHRQEAEKIAQRVFESATVIIAVSKEIKSYVSQYVSNPEKITVIPNGVNAQRFSDDVIKNSHKESNYRFTVGFVGSLKPWHGLPILIDSFARFNRDYPESRLLIVGDGAEKDFLVENVEQRQLQSAVQFVGAVSPDMIPYWLGKMDVGVAPYPSLDNFYFSPLKVYEYMAAGLPVIASNIGQIKELIEDGVDGLLCEAGDSLALTNALITLARSHLLRDKLGTSARAKILSHYTWNKVVDKILACVEQSRLRIKEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z784</accession>
    <name>K9Z784_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219953.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2141"/>
    <dbReference type="EnsemblBacteria" id="AFZ54228">
        <property type="protein sequence ID" value="AFZ54228"/>
        <property type="gene ID" value="Cyan10605_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2141"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2276"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_1_3"/>
    <dbReference type="OMA" id="GIVFDFA"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22368" checksum="C771B98B6DF52BCB" modified="2013-03-06" version="1">MNKEKKQLRKKYLQERLTLSPLQWQEKSKQICQHLSESLLVSNSKIILSYLSFKQEPDLSLLHHDKRKIWGLPRCQGNELIWHQFTSVNDLEIGKYGILEPSTHSPLIYPHQVDLILVPAVGCDRFGYRLGYGGGYYDRLFAQPLWQNIVRMGIVFDFAYVDKLIKESWDKPLDYICTESGIKTPIKEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z799</accession>
    <name>K9Z799_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220738.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2957"/>
    <dbReference type="EnsemblBacteria" id="AFZ55019">
        <property type="protein sequence ID" value="AFZ55019"/>
        <property type="gene ID" value="Cyan10605_2957"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2957"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3147"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_2_3"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="20029" checksum="6AE9A65C473F5F1D" modified="2013-03-06" version="1">MNIPNTITAIRIVLVLPLIYFLYQPSTSFQWLAFFIFLVAALTDWLDGYLARKLNQITALGKFLDPLTDKILIIAPLLILIERQQLRAWAVFIIIIREIVIAGWRVNPQLSSDNDISGANIWGKLKTVTQIGAIALLIIPVPQLTNIGLILFWIALVLTVISGSIYLGFPSFSLGKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D7</accession>
    <name>K9Z7D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220214.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2408"/>
    <dbReference type="EnsemblBacteria" id="AFZ54490">
        <property type="protein sequence ID" value="AFZ54490"/>
        <property type="gene ID" value="Cyan10605_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2408"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2553"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_0_3"/>
    <dbReference type="OMA" id="CGHVSKS"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="179"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="50457" checksum="32BF43655B0545F7" modified="2013-03-06" version="1">MKNYGCQQNLINPNPDSLAILEFLCEESNKLHNCGVYLGRQLWFKGRRYLKKFDLNKLLKNNNHYRVLYSQVAQQLLLSVTESFKSYYELQKQYHKKTITDKPRPPKYRKKGGFCGLTYPKQALKLRGNQIRLPLGKTVTRWFGLSEFFLPMPTNLSFSTIKELRIVPRNRLFYVEYVYEKKIVMQKNDPEKVLAMDHGIGNALSCVTNIGKSIIIDGKKAKSLNQWYNKKIAKLKEGKPQGFWSDDLARTTEIRNRQMRDFVNKSARYIVNFCRHHRIGTIVFGWNQGQKQSVNIGKKNNQSFVQIPMGKIKDRIHQLCDEHGLKFIELPEAYTSKSSFLDNDLIPNFGEKPEGYQFSGKRIKRGLYRSKQGFLVNGDVMAAANILRKYVSIQPVNISLAKVSRAVLTLPQRINIFNRGFNPIQYFFFESPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D8</accession>
    <name>K9Z7D8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin reductase domain protein FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mediates electron transfer from NADH to oxygen, reducing it to water. This modular protein has 3 redox cofactors, in other organisms the same activity requires 2 or 3 proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the flavodoxin reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220375.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2574"/>
    <dbReference type="EnsemblBacteria" id="AFZ54652">
        <property type="protein sequence ID" value="AFZ54652"/>
        <property type="gene ID" value="Cyan10605_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2574"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2734"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_2_1_3"/>
    <dbReference type="OMA" id="HVKNNIH"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="265"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="581" mass="64420" checksum="BDC29F7B3B199D0D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E0</accession>
    <name>K9Z7E0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">RuBisCO accumulation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">raf1</name>
        <name evidence="10" type="ordered locus">Cyan10605_3054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A major RuBisCO chaperone. Acts after GroEL-GroES chaperonin to fold and/or assemble the large subunit of RuBisCO (ccbL, rbcL). Cooperates with RbcX in RbcL folding, plays the major role in assembly of dimers into RbcL(8)-Raf1(8) intermediate complexes. RbcS replaces Raf1, leading to holoenzyme formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms an RbcL(8)-Raf1(8) complex. Forms complexes of many stoichiometries with RbcL with and without RbcS. RbcX and Raf1 can bind simultaneously to RbcL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Has 3 domains, the N-terminal alpha-helical domain, an extended flexible linker and the C-terminal beta-sheet domain. The 2 C-terminal beta-sheet domains are swapped and pack against each other to form the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RAF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220830.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3054"/>
    <dbReference type="EnsemblBacteria" id="AFZ55111">
        <property type="protein sequence ID" value="AFZ55111"/>
        <property type="gene ID" value="Cyan10605_3054"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3054"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3254"/>
    <dbReference type="eggNOG" id="ENOG502Z7IG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766477_0_0_3"/>
    <dbReference type="OMA" id="IVASQVY"/>
    <dbReference type="OrthoDB" id="951992at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110102">
        <property type="term" value="P:ribulose bisphosphate carboxylase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00856">
        <property type="entry name" value="Raf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037494">
        <property type="entry name" value="RAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040858">
        <property type="entry name" value="Raf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046382">
        <property type="entry name" value="Raf1_cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040781">
        <property type="entry name" value="Raf1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041358">
        <property type="entry name" value="Raf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35299">
        <property type="entry name" value="PTHR35299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18579">
        <property type="entry name" value="Raf1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18578">
        <property type="entry name" value="Raf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18087">
        <property type="entry name" value="RuBisCo_chap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="3 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Raf1_HTH" evidence="9">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Raf1_N" evidence="8">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCo_chap_C" evidence="7">
        <location>
            <begin position="206"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal alpha-helix" evidence="6">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal beta-sheet" evidence="6">
        <location>
            <begin position="218"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="358" mass="40732" checksum="FDBC53A4C70EFEEE" modified="2013-03-06" version="1">MTENNSLQQNLTAAEKEEIIRSLLHKEGCWVDWGKACQKLHDNGVSNQEIFEQTGLQNSHQNLVIVASKVFESLKQQEAEEDLLEYYRGPRSDVLYELRILNHQERLSAAKLVREKNLDVDGAKEIAKAMKEFSHLSQPPSGFTLNPGDAVAYQYWKNARQKKTLADKARLIAEGLKYAQSATARQQIESLLTDIAQTPQQNAPLLPMYRLESDEELPCILPVAGRFPLRVRDLDHVPILDAIEPFGVVNVKNSVSVVTIPSWQVILKAEKPAVIFCQGKDLPKETQNKSEELLIVVDLAVTEWNANHYFLTEEDDNLIFKWFNSSPQQRILGQLLVILRPKKILDEGNLTQPWQMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F2</accession>
    <name>K9Z7F2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220229.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2423"/>
    <dbReference type="EnsemblBacteria" id="AFZ54505">
        <property type="protein sequence ID" value="AFZ54505"/>
        <property type="gene ID" value="Cyan10605_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2423"/>
    <dbReference type="eggNOG" id="ENOG50318FE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1955942_0_0_3"/>
    <dbReference type="OMA" id="TRCRIQF"/>
    <dbReference type="OrthoDB" id="1882773at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14994" checksum="E0D31C3569571008" modified="2013-03-06" version="1">MSNIEKLQPANKDDTKMYLPFYNKEQQEILPYALSLYQQGYLEGERIIEGQQSIPFVAIWYVSRLPYEITRCRIQFEGSAELSYEVNLSNSEFIQYLILLIKNFKQSRQTDFSQKFYRKLLRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G5</accession>
    <name>K9Z7G5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyruvate phosphate dikinase PEP/pyruvate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2439"/>
    <dbReference type="EnsemblBacteria" id="AFZ54520">
        <property type="protein sequence ID" value="AFZ54520"/>
        <property type="gene ID" value="Cyan10605_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2439"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2583"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005950_0_0_3"/>
    <dbReference type="OMA" id="WTRKIAA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="262"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="881"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="964" mass="108274" checksum="115223C608E35E17" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N8</accession>
    <name>K9Z7N8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_3111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220883.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3111"/>
    <dbReference type="EnsemblBacteria" id="AFZ55164">
        <property type="protein sequence ID" value="AFZ55164"/>
        <property type="gene ID" value="Cyan10605_3111"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3111"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3315"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="AYHCIAG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="10">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="498" mass="55181" checksum="8999EB013806F5D4" modified="2013-03-06" version="1">MEEAIASRYKIIKNLGSGGFGDTFLAQDLQMPSARQVVIKKLKPVHHNNISLEFIETLFEKEAKVLEELGQNCPQIPTLYAYFRENEEFYLVQEYIEGKSLAELGVIHPNQCESILSSLLNTLKYVHGKNIIHRDIKPENIILRDSDKLPVLIDFGAVKESMGAVQLSSGSTVSSVIIGTRGFIPPEQSTGRTVFSSDLYALSLTIIYSLTGKYPIELPNNNITGELDWQSYIPNLPLNLKTVLEKASKIDLAQRYPTAQEMYEALHLSQGQTMAVTPNPIDLQKSSTPNLAPTVLIPNSMASVPQQVSQVSQPLVAPQKNNLLVILITALLVALGVSGGFFVVQQMKETQARLEEIEKEKEETEARLAEEQTKREEEELKRQESEKMRLEAEKERAKAEELRRQAEIKAQSQPQIRTVVVNPSSLTDGSYGTITGSTGSKNIRSGPGTGYPVVGEGYTGESIEILDSGYDNGGYLWYKVYHPSSGVTGWMAGQLVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R0</accession>
    <name>K9Z7R0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exoribonuclease II</fullName>
            <ecNumber evidence="3">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220162.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2354"/>
    <dbReference type="EnsemblBacteria" id="AFZ54438">
        <property type="protein sequence ID" value="AFZ54438"/>
        <property type="gene ID" value="Cyan10605_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2354"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2499"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_3"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="655"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="749" mass="84713" checksum="C8EB38F251987FA3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U0</accession>
    <name>K9Z7U0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220969.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3203"/>
    <dbReference type="EnsemblBacteria" id="AFZ55251">
        <property type="protein sequence ID" value="AFZ55251"/>
        <property type="gene ID" value="Cyan10605_3203"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3203"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3415"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_2_3"/>
    <dbReference type="OMA" id="QRDESWW"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="526"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="806" mass="88653" checksum="41BE7E76DBA9E8A9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U1</accession>
    <name>K9Z7U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2730"/>
    <dbReference type="EnsemblBacteria" id="AFZ54802">
        <property type="protein sequence ID" value="AFZ54802"/>
        <property type="gene ID" value="Cyan10605_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2730"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_3_3"/>
    <dbReference type="OMA" id="AKIRICK"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="9681" checksum="14A1A07591140893" modified="2013-03-06" version="1">MMKSNNNIPLTNLECGKTAIINQIITGIHGQALTTRFQSLGLVSGKKVKVIRKSWLGGTLHVKVGSTTAIALRSQEADLVLVNNPEKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A3</accession>
    <name>K9Z8A3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221097.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3337"/>
    <dbReference type="EnsemblBacteria" id="AFZ55379">
        <property type="protein sequence ID" value="AFZ55379"/>
        <property type="gene ID" value="Cyan10605_3337"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3337"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143452_1_1_3"/>
    <dbReference type="OMA" id="LGHGRIF"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17598" checksum="D9D19775665F6444" modified="2013-03-06" version="1">MIIVDTGFWISLFNDKDQYHQRAKKTLAKYSSEPLVITWSVLTENCHLLLQRSITKQKGVEKQVQLINLFDQYPEMFKIFNIREHHFPKMKELMKKYANLPIDLADASLIVLAEDLGDGRILSVDNRDFNAYRWKQTYPFTNLFFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D8</accession>
    <name>K9Z8D8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220361.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2558"/>
    <dbReference type="EnsemblBacteria" id="AFZ54638">
        <property type="protein sequence ID" value="AFZ54638"/>
        <property type="gene ID" value="Cyan10605_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2558"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2715"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_3_0_3"/>
    <dbReference type="OMA" id="AIGTNHI"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="32085" checksum="1535F8C37A9C5992" modified="2013-03-06" version="1" precursor="true">MNFEYWYMFPFSIVIATIAMASGVEGATFFTPLFMLVLKLPPEVAIGTGLITEVFGFSSGLFAYIRKGLIDFKLGKKLLIVTIPLALIGTWLGKLISPSALKAMLGVGLFVIAQSFLSNPESEEIEVLDANIASHSRENPQTCLTSNDGETFCYTIANTTEGRLLSGIGALFLGMVSTGLGELNGYFLIQRCKVPSQVAVATSVFIVAITALIASVGHVLQFLQAGNDELMTVLSLVIFTAPGVLIGAQFGSMVASKLSQKLLERSMGILFIIVGAIVLFELAVKNQDLISSFIYISMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E1</accession>
    <name>K9Z8E1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">leuC</name>
        <name evidence="14" type="ordered locus">Cyan10605_2935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220716.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2935"/>
    <dbReference type="EnsemblBacteria" id="AFZ54997">
        <property type="protein sequence ID" value="AFZ54997"/>
        <property type="gene ID" value="Cyan10605_2935"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2935"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3123"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_3"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="8"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="51266" checksum="486011B43173E7CD" modified="2013-03-06" version="1">MSKGTLFDKVWDLHTVGTLPSGQTQLFIGLHLIHEVTSPQAFAMLRERKIKVLYPERTVATVDHIVPTENQARPFADSLAEEMIQALEKNTEENNIRFFNTHSGNQGIVHVIAPEQGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTSQVRDVLASQTLSLTKLKVRKIEVNGDLAPGVYAKDVILHIIRKLGVKGGVGYAYEYSGTTFEKMSMEERMTVCNMSIEGGARCGYVNPDDVTYNYLKDKDFAPKGEKWEEAVKWWNSLRSDEDAEYDDVVTFSASDIEPTVTWGITPGQGIGISESLPILDELSESDREIALQAFEYMQLQPGESLKGTPIDVCFVGSCTNGRISDLREAAKFAKGHKVAQNVKAFIVPGSERVKQQAEAEGLHNIFINAGFEWREPGCSMCLAMNPDKLQGSQISASSSNRNFKGRQGSAQGRTLLMSPAMVVAAAINGKVADVRDLEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I9</accession>
    <name>K9Z8I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220761.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2982"/>
    <dbReference type="EnsemblBacteria" id="AFZ55042">
        <property type="protein sequence ID" value="AFZ55042"/>
        <property type="gene ID" value="Cyan10605_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2982"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3176"/>
    <dbReference type="eggNOG" id="ENOG5032YDH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187684_1_1_3"/>
    <dbReference type="OMA" id="FHFGLTT"/>
    <dbReference type="OrthoDB" id="2009670at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021702">
        <property type="entry name" value="DUF3285"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11688">
        <property type="entry name" value="DUF3285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="6984" checksum="14A4225F8694A622" modified="2013-03-06" version="1">MTNSSKIEPENIDNSQEKGKDSYVKLAMRNMVKKRGTSLKHFFLTTFGLLVFLVGISYLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R7</accession>
    <name>K9Z8R7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">Cyan10605_3060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220836.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3060"/>
    <dbReference type="EnsemblBacteria" id="AFZ55117">
        <property type="protein sequence ID" value="AFZ55117"/>
        <property type="gene ID" value="Cyan10605_3060"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3060"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3261"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_2_0_3"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="31004" checksum="1F0C9753B928C8AB" modified="2013-03-06" version="1">MSGFLYLVATPIGNLEDITFRAIKVLQSVDIIAAEDTRHTGKLLKYYQISTPTISYHQHNHQSRVQELLTKLEDGLSIALVTDAGTPAISDPGYHLVSACIKHQINIIPIPGAIAAINGLIASGLSSDRFCFEGFLPQKKKEKDNLLKDLQGEKRTIIFYEAPHRLLKTLKDFSQYFGDNRRITLARELTKLHEDFWRGTIKDAIAFYQNQNPKGEFTIIVEGNQHQEIVELSPTQIKEEIEQLMAKGMTKSEACQELAKYSNLSRREIYKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T6</accession>
    <name>K9Z8T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2948"/>
    <dbReference type="EnsemblBacteria" id="AFZ55010">
        <property type="protein sequence ID" value="AFZ55010"/>
        <property type="gene ID" value="Cyan10605_2948"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2948"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3137"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102914_0_0_3"/>
    <dbReference type="OMA" id="YLEPANV"/>
    <dbReference type="OrthoDB" id="1624852at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="28003" checksum="453867858EB40517" modified="2013-03-06" version="1">MMKTILKQLSLKQFALGMLTKWHCAIPKGTTTQYALITVLQITSFLLQTPIAKADSPLTSTDLASAYQDLMVIDTIQEKQPLQGEALRFLLSNAPLDEKAAVINKLGWNIDGQNNGYIFLQALAKKKGVAVNNLVLTDLTPKDKFVLGYLLAMDDYFNLSPLDTNSNNNLFSATPLDLLSQAAFAMPEDFTVHFIKSLVEAQLYFDVSWCAIYLTPQSVLRIFPTETRNLRPSAVSKTMEYINLYQDNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z926</accession>
    <name>K9Z926_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2816"/>
    <dbReference type="EnsemblBacteria" id="AFZ54883">
        <property type="protein sequence ID" value="AFZ54883"/>
        <property type="gene ID" value="Cyan10605_2816"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2816"/>
    <dbReference type="HOGENOM" id="CLU_3167071_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="47" mass="5062" checksum="EC276308401571D7" modified="2013-03-06" version="1">MLHSLTSVRDKFSSMNDGEKGKGQGENLKGQWAKVNSVGVLGRIVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z939</accession>
    <name>K9Z939_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220625.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2836"/>
    <dbReference type="EnsemblBacteria" id="AFZ54903">
        <property type="protein sequence ID" value="AFZ54903"/>
        <property type="gene ID" value="Cyan10605_2836"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2836"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3014"/>
    <dbReference type="eggNOG" id="COG1565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_1_1_3"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="1220759at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="390" mass="45172" checksum="45EF84E88CE36D47" modified="2013-03-06" version="1">MTNNKSNLLQKKIIELIDSSNQKKITFADYMNLCLYDSEYGYYNSENILIGKNGDFYTSTSLSSDFGELLAIQLEEFWRVMDKPTPFHLVEVGAGEGNLTINILNYLKTHYPDFFQSIEYIIIEKSEILAEKQKQIIKKSFNKSVISKWYKWEDIENNSLQGCIFSNELIDAFPVHLVEFNQGILQEVYLTNNEGNLTEVLGNLSTIEIEDFFKTLNINFSQDIYPEKYRTEVNIQALNWLKTVTKKLKKGYVLTIDYGYQGDKYYHPQRFQGTLKCYYQHRHHNNPYVNIGCQDITSHINFTALETYGERYGLSNIAYTPQALFLMNLGLGDRISELSSGKIPIGEIIERRNQLHSLINPEGLGNFGILLQGKNLNKEQKNYSLKGFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z955</accession>
    <name>K9Z955_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3083"/>
    <dbReference type="EnsemblBacteria" id="AFZ55140">
        <property type="protein sequence ID" value="AFZ55140"/>
        <property type="gene ID" value="Cyan10605_3083"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3083"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3285"/>
    <dbReference type="eggNOG" id="ENOG50317WH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116628_0_0_3"/>
    <dbReference type="OMA" id="YLAYWFQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17264" checksum="4FDAE2F8849D3945" modified="2013-03-06" version="1">MIISMAESAKVKKYLAYWFQLGKKIIIPSQNTAILPSKILNGHGYANEFEECWQLVTDENTGDCYLEGTSQTIQQLLSSQWDITECARCSMPVPMIDVGIQNSSCVCNDMDNWPNNELPYPRQPINNQENLKRISESLKQKKISKNDIIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E8</accession>
    <name>K9Z9E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220918.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3149"/>
    <dbReference type="EnsemblBacteria" id="AFZ55200">
        <property type="protein sequence ID" value="AFZ55200"/>
        <property type="gene ID" value="Cyan10605_3149"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3149"/>
    <dbReference type="eggNOG" id="ENOG5034350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2116952_0_0_3"/>
    <dbReference type="OMA" id="HAYQYEI"/>
    <dbReference type="OrthoDB" id="1944236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="13877" checksum="C8463D0B7453891F" modified="2013-03-06" version="1">MFPFPPRKPNKKVIIPQKKNFPSSSPRRVNIPSHFQKNPLITYSQIEIERELQKYPGLLRTLSHAYQYQVTFMDDKTENQYWFCRNIELTMILLKYLNEKNWSVDWQEKPFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G1</accession>
    <name>K9Z9G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ordered locus">Cyan10605_2966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220747.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2966"/>
    <dbReference type="EnsemblBacteria" id="AFZ55028">
        <property type="protein sequence ID" value="AFZ55028"/>
        <property type="gene ID" value="Cyan10605_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2966"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3157"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_3"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="27503" checksum="E468D757C87A6D9D" modified="2013-03-06" version="1">MLAKRILPCLDVNAGRVVKGVNFTNLKDAGDPVELAKLYNDAGADELVFLDITATHEARDTIIDVVYRTAEQVFIPLTVGGGIKTLENVKDLLRAGADKISVNSTAVRNPDFINKASERFGSQCIVVAIDARRREDANNPGWDVYVRGGRENTGIDAVAWAKEVTERGAGELLITSMDADGTQAGYDLKLTKTIAEMVEIPVIASGGAGNCHHIYQALTEGKAEAALLASLLHYGQLTVEEIKKYLSSHQVPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P2</accession>
    <name>K9Z9P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221160.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3400"/>
    <dbReference type="EnsemblBacteria" id="AFZ55442">
        <property type="protein sequence ID" value="AFZ55442"/>
        <property type="gene ID" value="Cyan10605_3400"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3400"/>
    <dbReference type="eggNOG" id="ENOG503304D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184319_1_0_3"/>
    <dbReference type="OMA" id="NREIHEV"/>
    <dbReference type="OrthoDB" id="2077439at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021336">
        <property type="entry name" value="DUF2949"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11165">
        <property type="entry name" value="DUF2949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="63" mass="7378" checksum="90A20E3D62F6E02B" modified="2013-03-06" version="1">MPTITYTRFIKFLQDEINLSQDSIAMAQKTVDQNLGLMPVVLWQYGLVDLQQLNKIYEWLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T8</accession>
    <name>K9Z9T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55138">
        <property type="protein sequence ID" value="AFZ55138"/>
        <property type="gene ID" value="Cyan10605_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3081"/>
    <dbReference type="HOGENOM" id="CLU_2989072_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="57" mass="6159" checksum="4283030597AF1AE5" modified="2013-03-06" version="1">MEAGEPSRKKKGFKQVSVEILGTLIALTTLTIPIFLITNFSDNSNSSPAKSLLLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA03</accession>
    <name>K9ZA03_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221269.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3519"/>
    <dbReference type="EnsemblBacteria" id="AFZ55552">
        <property type="protein sequence ID" value="AFZ55552"/>
        <property type="gene ID" value="Cyan10605_3519"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3519"/>
    <dbReference type="eggNOG" id="COG5314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035317_0_0_3"/>
    <dbReference type="OMA" id="MISINTI"/>
    <dbReference type="OrthoDB" id="1819594at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="452" mass="50868" checksum="A470F6631458B7B6" modified="2013-03-06" version="1">MNLSDNFDKVRSDITWLISTRPDLVAKAKLIAQGKYDPNQDNTLDNNDKKFLRCFLNLIIVNPNDLHGKVYVTDNVESRSHLTASSITIANWINGISNFPLFFFLVETTFLPIVGGMGAILATGAVLGIGNTFGASVAKCRKGNRSWSLWGGLLALVGLNVIQTGATGIGVEMMNNRSELNRIYATKIANNYLTDKENQITYLQQSENPIYLNVKERCDVGTTQFNTLPPRHPNRDALYVSLYGAFAQKDTNWNNLPFEKLPVCRQVTRLENEKNQELETAILSYQNLLTERSQTGSDLVFLEKFALQVFNEHFTNQREIKSGTILVGLATTEVFNKLSKGKWTELGLSYFIFILSAITSIASCVMALTHALSKDVQNSYDPQLQIIIDDYFQEMRQALMIAQANDTHIISELDPTIQSLENSYHYEYEPNDMGTGNINHPLPEGNEKEWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA83</accession>
    <name>K9ZA83_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3227"/>
    <dbReference type="REBASE" id="58389">
        <property type="entry name" value="Cap10605ORF3227P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55273">
        <property type="protein sequence ID" value="AFZ55273"/>
        <property type="gene ID" value="Cyan10605_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3227"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3441"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002151_1_1_3"/>
    <dbReference type="OMA" id="PPYNANQ"/>
    <dbReference type="OrthoDB" id="45009at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="867"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1265" mass="149064" checksum="4DFDEEA00C2CBEB3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAZ4</accession>
    <name>K9ZAZ4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221270.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3520"/>
    <dbReference type="EnsemblBacteria" id="AFZ55553">
        <property type="protein sequence ID" value="AFZ55553"/>
        <property type="gene ID" value="Cyan10605_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3520"/>
    <dbReference type="HOGENOM" id="CLU_1719301_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="17153" checksum="02498A87AE784D3C" modified="2013-03-06" version="1">MKKNGKIDLPTIQALVNQYQEGEIIPSQPTPETTPSPNPSQFSANYTKINSDNNTINNTNVTNVPPPENPPVKIEAEIINEDKEKKAPISETITVNNEIPIDTQQLERIILELQLTETAQNLAKPPKKRLKSPHLGEIEKRLNQFIYKNNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ30</accession>
    <name>K9YZ30_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217901.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0008"/>
    <dbReference type="EnsemblBacteria" id="AFZ52169">
        <property type="protein sequence ID" value="AFZ52169"/>
        <property type="gene ID" value="Cyan10605_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0008"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_4_1_3"/>
    <dbReference type="OMA" id="FICESDF"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="20851" checksum="24B2B8AA46F66612" modified="2013-03-06" version="1">MKKREYWLDLLHHVPKWNHWRELNPEETIDLSGINLNSYDLEAINFSGCNLSHVNFIGSNLRFANLSSADLSHSNLIGVNLRLANMRQSVLFKARLHRSNLSEANMVQSFICESDFSKAIFYETELGESKIYKTSFSHAKLVNTHLGKADIFMCNFDHAIMESVDLRWANVIKTSINFNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B6</accession>
    <name>K9Z0B6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217899.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0006"/>
    <dbReference type="EnsemblBacteria" id="AFZ52167">
        <property type="protein sequence ID" value="AFZ52167"/>
        <property type="gene ID" value="Cyan10605_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0006"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347034_0_0_3"/>
    <dbReference type="OrthoDB" id="1457810at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="23056" checksum="49923F469C5748EB" modified="2013-03-06" version="1">MNSPRQHSSEALALEVASLKKLVVDLSKYKRAMEAQKELFRSILMMSNVASGKLMLRSILLEISEVTRDLLKAQDASLFILNPKGVITESILARGPTIQEEKTHLIGTILDRGLAGWVYRYRRMALVKDTQQDERWLNFENQPYEVGSALCVPFLRGSLVLGILTLTHPKPRHFNEDMEDFMSMFSPSIAIALDHARVYLESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0E6</accession>
    <name>K9Z0E6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0016"/>
    <dbReference type="EnsemblBacteria" id="AFZ52177">
        <property type="protein sequence ID" value="AFZ52177"/>
        <property type="gene ID" value="Cyan10605_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0016"/>
    <dbReference type="eggNOG" id="COG5279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047114_0_0_3"/>
    <dbReference type="OMA" id="YTHFPEN"/>
    <dbReference type="OrthoDB" id="1574236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="505" mass="58262" checksum="E83A36ED49456EE7" modified="2013-03-06" version="1">MTTLVFIMTTEREYREWHKQRNKQVKRRQRKKSNFGFFVFLIIAISLGVTIKSNPQIIDYLQNQLESPNLSSFFNAFRFRVNSLKSLTEEFITEIDEPVVITENYQLLEKRNFSDIDRKAKSIKYTGNSVEELSQILSKYAKTEADKARIIYTWITYNISYDVGALNDLFNNNIYPDVRTEIVLNTRSTICSGYANLYQQLAKKMGLKSVIILGYAKGENYIVGLDNNVNHAWNAVKIDSNWYLIDTTWGSGTVTNNGFNAQFNPFYFATNPREFIYTHFPENDKWQLLNPIMSRSEFDSLANVSPTLFEYDIQLLSHPNVNISTDENNVNIALKVPKNVIAIASLKSKEKQLQDNYTFVQKQGENILINASFPEKGEYKLDIFAKPKDETNSYPLVVSYNILASGNGNQFPKTFQHFNEYNGYLETPLNNSLNPNQNTYFKLKIDQALEVKAVNKSTNQWHDLERYGNVFAGNINVGNGDIILYAKFPQDSRYWALLEYGNNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V2</accession>
    <name>K9Z0V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hexapeptide repeat-containing transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218520.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0650"/>
    <dbReference type="EnsemblBacteria" id="AFZ52789">
        <property type="protein sequence ID" value="AFZ52789"/>
        <property type="gene ID" value="Cyan10605_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0650"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.686"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_4_0_3"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="18169" checksum="6FD8FB76A568FC9A" modified="2013-03-06" version="1">MKQLNINSFTQAAFIAENASVMGQVTIGEGASIWYSAVVRGDVEKIKIGAYTNIQDGAIIHGDPHQETILEDYVTVGHRAVIHSAHIKKGCLIGIGAIILNGVTVGEGSIIGAGCVVTKDVPSHSLMVGIPAKKIRDVNEEETQNLIQHALKYYQLGLYHAGKTSDKGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V9</accession>
    <name>K9Z0V9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ordered locus">Cyan10605_0024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217917.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0024"/>
    <dbReference type="EnsemblBacteria" id="AFZ52185">
        <property type="protein sequence ID" value="AFZ52185"/>
        <property type="gene ID" value="Cyan10605_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0024"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.25"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_3"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="39009" checksum="F7431689A30EFF9A" modified="2013-03-06" version="1">MSPDQQLSSYDYYLPSELIAQNPVTPRDSSRLLVIEGENSPKHQIFADLPQFLSAGDLLVVNNTRVIPARLYGEKSTGAQVEVLLVEETRDNCWLALVKPGKRFSVGSEIYFGDGLLKATVVDKDEATGGRYLEFSWQEGESFWHLLEKVGNIPFPPYVTESSANPSQYQTVYAQKQGAIAAPTAGLHFTDRLFEQLKAEGINKTEVTLHVGIGTFRPVEVEDIVNHDMHQEWIEIDEATVNLIRATKARGNKVIAVGTTVVRTLEGVCKECGDLQAFEGKTNLFIYPGYEFKVIDGLITNFHLPKSSLLMLVSALIGRERLMMVYEEAIREKYRFYSFGDAMLIKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y7</accession>
    <name>K9Z0Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218597.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0732"/>
    <dbReference type="EnsemblBacteria" id="AFZ52866">
        <property type="protein sequence ID" value="AFZ52866"/>
        <property type="gene ID" value="Cyan10605_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0732"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.768"/>
    <dbReference type="HOGENOM" id="CLU_028870_0_0_3"/>
    <dbReference type="OMA" id="WLSWEDL"/>
    <dbReference type="OrthoDB" id="1879368at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="491" mass="56565" checksum="1175DDBEABA3CFEA" modified="2013-03-06" version="1">MSFPPTSSKPYKSRLLNFVNRNYIKINSQINTKFREWGYVIKGGLQDILLPFVWLWRKTNINQVFTGEKKSNASLPYSRCDELIVTVREKMTVEKDFPLLLTHEFQGLASQINNRKIVAIVGNNKSKDIIPIQKQEEIVSLIKIIVQDYELRKYPNTLITWIDKFIAQVESVIVSKQDDEEENTLNNISEEIINQQENFSLINIIKSAIDYFFGNKNTHNGLNGNVEAEVNQITSNKQDKSLSSLKGQKNNNVLPLSKKNNASLVNINIIPQAKNISNKIINLTINQLANISNSININSNKNNDPFQIKLIILAAIEYFFSKDKKISNPQINSDNKNEKLTILAGSDVIIIREEISESWLSWEDLYGDNNSSYIENNQQLTPSQDESFNTNQQKKIETDSKNNSDNFLSSNNINNADKISNKNKEETDNLVNQNSLNHQNNLDAENEIEIEAKVIEIKYEKHFLQFILEKLDQLILWIEEIIIKIIKKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z111</accession>
    <name>K9Z111_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="11" type="ordered locus">Cyan10605_0272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218154.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0272"/>
    <dbReference type="EnsemblBacteria" id="AFZ52422">
        <property type="protein sequence ID" value="AFZ52422"/>
        <property type="gene ID" value="Cyan10605_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0272"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.282"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_3"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="460" mass="51239" checksum="C005F573ACD1EB9E" modified="2013-03-06" version="1">MRTEWIAKRRGQANVSQMHYARQGVITEEMHYVATRENLPAELIRDEVARGRMIIPANINHPNLEPMCIGIASKCKVNANIGASPNSSNIDEEVAKLNLAVKYGADTVMDLSTGGGNLDEIRTAIINASPVPIGTVPIYQALESVHGKIENLTADDFLHIIEKHAQQGVDYMTIHAGILIEYLPLVRNRITGIVSRGGGIIARWMLHHHKQNPLYTHFDDIIEIFKKYDVSFSLGDSLRPGCTHDASDEAQLSELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPNAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSKARYNFDWNRQFELSLDPDRAREYHDETLPADIYKEAEFCSMCGPKFCPMQTKVDADALTELEKFLAKEASSKQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z148</accession>
    <name>K9Z148_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218189.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0309"/>
    <dbReference type="EnsemblBacteria" id="AFZ52457">
        <property type="protein sequence ID" value="AFZ52457"/>
        <property type="gene ID" value="Cyan10605_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0309"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.321"/>
    <dbReference type="eggNOG" id="ENOG502ZR9C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1755218_0_0_3"/>
    <dbReference type="OMA" id="HFPGWSP"/>
    <dbReference type="OrthoDB" id="1459349at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="137" mass="15735" checksum="FC520DD3A57B97CC" modified="2013-03-06" version="1">MNASEKAKGLETTSKIASIVNLFKQNFPDAKADLKPWQNDPDTINLVDPDSIDIGFHFPGWSRSLQSRSILVQIRFHRDSEEETHHFIGIETAGFTHAGEVWRLSTIDNWQLEGKYLPTEEITNKLKEFCRGVFQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z167</accession>
    <name>K9Z167_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218037.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0148"/>
    <dbReference type="EnsemblBacteria" id="AFZ52305">
        <property type="protein sequence ID" value="AFZ52305"/>
        <property type="gene ID" value="Cyan10605_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0148"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.154"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_3"/>
    <dbReference type="OMA" id="TPKVWDI"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="30858" checksum="E5580CD03C7D9A8B" modified="2013-03-06" version="1">MIYFWHQVYNFCHQITHRIGESLLADFAQLEPTRKADGSLVTKADKWADEELRLGIKQCFPTHGVLTEETEHILPPNEWCWVIDPIDGTTNFTRGIPIWGISIGLLYRGIPVFGFVHFPQVQQTYHGYYYGNTGLTGPKGAFLNNNLISTSDASPTMNHVVTMCNRSLDILKHDFPCKVRITGVTSYDLISVACGATLGAIEASPKIWDVAGAYPILLAAGGNFVHIDPENAFPLTKGVNYGNISFPCLAVAKENLISVFKPLVESIYQPKSLLNLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G9</accession>
    <name>K9Z1G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP dicarboxylate transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218745.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0884"/>
    <dbReference type="EnsemblBacteria" id="AFZ53014">
        <property type="protein sequence ID" value="AFZ53014"/>
        <property type="gene ID" value="Cyan10605_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0884"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.929"/>
    <dbReference type="eggNOG" id="COG4664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019824_4_0_3"/>
    <dbReference type="OMA" id="IVVNMEV"/>
    <dbReference type="OrthoDB" id="941328at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="11"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="445" mass="47477" checksum="EBB4614373916968" modified="2013-03-06" version="1" precursor="true">MSYDWLGLLMFVGALVFLSSGYPVAFSLGGVALIFALIGSLLGVFDPIFLTAMPSRIFGIMSNYTLLAIPYFIFLGSMLETTGIAEKLLETMGILFGRMRGGLALAVVVVGALLAATTGVVAATVVAMGLISLPIMLRYGYNKQLATGVIAASGTLGQIIPPSVVLVVLADQLGLPVGDLFIGSLIPGLLMAGVFAAHVLIVAWLRPDCAPALPLEVRKISGKQLWVRVTQAMFPPLILIFLVLGSIFWGIATPTEAGAIGSFGAMILAMLNGRLTWQMVLKACKSTMLITTMVMFILLGSTAFSLVFRGIGGDRIIEELLVNLPGGVWGFLAVNMLLIFILGFFIDFFEIAFIVIPLFAPAAQLLGIDLLWYGVILGANLQTSFLTPPFGFALFYLRGVAPPEVSTEDIYKGAIPFILLQLFVLILIIIFPALVNFLPSLSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I5</accession>
    <name>K9Z1I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218802.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0941"/>
    <dbReference type="EnsemblBacteria" id="AFZ53071">
        <property type="protein sequence ID" value="AFZ53071"/>
        <property type="gene ID" value="Cyan10605_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0941"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.992"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489866_0_0_3"/>
    <dbReference type="OMA" id="HQPLFWD"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="549" mass="63127" checksum="8413E867CB8E81A2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z9</accession>
    <name>K9Z1Z9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52742">
        <property type="protein sequence ID" value="AFZ52742"/>
        <property type="gene ID" value="Cyan10605_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0603"/>
    <dbReference type="eggNOG" id="ENOG5033H14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406688_0_0_3"/>
    <dbReference type="OrthoDB" id="1669101at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="22784" checksum="72C7556019AD3474" modified="2013-03-06" version="1">MNDNLKIDNLDDLNSVLKTNNIDINQWNHQQGNKTIEELYQEIKEGESQLKLIQGKLVRLMKVSAIEVIFNLGNNYFQLIEDKQIFLTGIVRRREQNFITEKIKGGENSLQGAYRGLEEEIGLKTEKKLNLMRETVWEKISPSYPNLMTFYKVFNYRIILGEEELKQIRFSEYREQEKIISLFTLTPTKFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B4</accession>
    <name>K9Z2B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0554"/>
    <dbReference type="EnsemblBacteria" id="AFZ52695">
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        <property type="gene ID" value="Cyan10605_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0554"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.584"/>
    <dbReference type="HOGENOM" id="CLU_2616074_0_0_3"/>
    <dbReference type="OrthoDB" id="1952655at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="8828" checksum="A1DCE66EC7C5BEA2" modified="2013-03-06" version="1">MISCLTCDSNQLDYPCSEKVSAEIVAEAIASLVEKTHYEGKSLEDLIKEVLAEDQILDQVQRRWLSKIVTQAWKSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C7</accession>
    <name>K9Z2C7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218618.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0754"/>
    <dbReference type="EnsemblBacteria" id="AFZ52887">
        <property type="protein sequence ID" value="AFZ52887"/>
        <property type="gene ID" value="Cyan10605_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0754"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.792"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="25957" checksum="4FA82D121EDC9DF5" modified="2013-03-06" version="1">MTNLLEVQDVYAGYIKDLNILQGINFRIESHELVTVIGPNGAGKSTLAKTIFGLLTPNEGKIIFKGENIAGLKPNEIVKLGMCYVPQIVNVFPSLTIEENLEMGAYILSGSSNRQKDLIYTMFPKLKERAKQKAGTLSGGERQMLAMGRALMLDPDLLILDEPSAALSPILVSSVFEQIKAINEAGKAIILVEQNAKKALMMAHRGYVLESGKDAIEGKGSDLLNNPQVGELYLGTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D4</accession>
    <name>K9Z2D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219095.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1248"/>
    <dbReference type="EnsemblBacteria" id="AFZ53366">
        <property type="protein sequence ID" value="AFZ53366"/>
        <property type="gene ID" value="Cyan10605_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1248"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1316"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_4_3"/>
    <dbReference type="OMA" id="KYEVLQW"/>
    <dbReference type="OrthoDB" id="1383885at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21274" checksum="816D9E62B5B16C63" modified="2013-03-06" version="1">MNRKIKLYGGSRSRASIIQWYLEEIGADYEFILLDMANKEHLSPEFLKLNPMGKVPVIIDGDFILWESGAILLYLAEKYGQEIDSLETRSIFNQWILFANSTLSTGLFIEANREREISKLLPPLEKILQSHSFLLGDKLTVADIAVGSMLAYTQILLKLNLRDYPAISNYIDTISQRPAFSKTIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H0</accession>
    <name>K9Z2H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0434"/>
    <dbReference type="EnsemblBacteria" id="AFZ52578">
        <property type="protein sequence ID" value="AFZ52578"/>
        <property type="gene ID" value="Cyan10605_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0434"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="HILAVEC"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="312"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="454"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="709" mass="81061" checksum="90B80E3B6A1AE529" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I9</accession>
    <name>K9Z2I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218511.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0641"/>
    <dbReference type="EnsemblBacteria" id="AFZ52780">
        <property type="protein sequence ID" value="AFZ52780"/>
        <property type="gene ID" value="Cyan10605_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0641"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093778_0_0_3"/>
    <dbReference type="OMA" id="WQINLAT"/>
    <dbReference type="OrthoDB" id="1689289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="29004" checksum="6F13AC033B1A86C0" modified="2013-03-06" version="1">MKITSGFISLILKLVGGILLISSLINYVFFLISPQWQDPNWQINVTNGAIEQGITPLIAIAFLLVAWWIGDNNNSEKPNKPVRMIVFIIASILGLVYLLLVPLHFGNINRVSSDLFVQIDQRIAQQEAQIQGFVSELEAISKNPEQLKQEIEQRNQIIQAGGNLGGQQLNPQQLQSITTQRDQLQQILNLSDKPEELKAKFQEVRNQLESELQKAVEQEKRKAQGLALQQSLKTSISSLMLAIAFIAIGWLGLQKMLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J8</accession>
    <name>K9Z2J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0651"/>
    <dbReference type="EnsemblBacteria" id="AFZ52790">
        <property type="protein sequence ID" value="AFZ52790"/>
        <property type="gene ID" value="Cyan10605_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0651"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087926_0_0_3"/>
    <dbReference type="OMA" id="VLENNHQ"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21574" checksum="3B86747F7418E676" modified="2013-03-06" version="1">MRDYAPSPTIFRQATLDDVEGIAEVLTLSFNHFNEVTFWVYPLIKIGVCQDLRKRLQNNEKENICLIAVFINNTEGKVNQEILGTVELSFRENYRWAKKEKYAYIANLAVRENCRRQGIASQLLSRCEQIAQENNYSHVYLHVLASNHKARKLYLNNGYTIQQVETDLFSLFIPSQRRLLLTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N3</accession>
    <name>K9Z2N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218561.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0694"/>
    <dbReference type="EnsemblBacteria" id="AFZ52830">
        <property type="protein sequence ID" value="AFZ52830"/>
        <property type="gene ID" value="Cyan10605_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0694"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989434_0_0_3"/>
    <dbReference type="OMA" id="QCRIWGE"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="32732" checksum="70FF7BD829648BEB" modified="2013-03-06" version="1">MQLEQYSLNYVVKSFLIDLIKAIDINNPHSQLSLSNLSLQLSTDTDSFVYKTPIFEQLKINSPQLKNLLTQKLLTLFEENYSYGDFKVKINSSHWLEIAVCDPEGICGTGGILNQWLNNLSRVTKINIIKQKNNSNKTEKKAKFIYYYTHARCCSILTSAHKQNLIQLNNLDFKINDWYWQKTKDINFNSLNFYKGYESKLIRELVIIIDKIEANKINYLTSLENLTQKILDVEKHCRIWGKVLKNNKDISLARLALIMIALKYYQALIYAQFSLELPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T3</accession>
    <name>K9Z2T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1350"/>
    <dbReference type="EnsemblBacteria" id="AFZ53464">
        <property type="protein sequence ID" value="AFZ53464"/>
        <property type="gene ID" value="Cyan10605_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1350"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1424"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_3"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="42251" checksum="C3FACD2C2F50EF67" modified="2013-03-06" version="1">MNNIEKEKIYWLAWSKIKGIGAVSLKRIYDYFGSVELAWKINESELLKIEGIGKKLVNKIKEEKGKINPEQLYIKHKEKNPQFITPFERKYPQLLLEIPSPPPVLYYQGEIDISENQGLTPLIGIVGTRKPTEHGKRWTYNISKVLAQNGFTIVSGLAEGIDTIAHRGCLDGGGRTIAVLGNGLDRVYPSNNKQLMAEIAEKGLILTEYDYGSLPERGNFPARNRIVAGLCRAILVMEAPEKSGALITAHYATEFNRDVYTLPNTPDNIQARGCLRLIHNGAEVIITEKELLSSLGAIPDLNSPQQLSLFAETSSPPTLLETPKPNLSEPLSIVYDAIASSPTPFDVIVNQSNLTSAEVSGILLQLELEGLVTQLPGMMYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y1</accession>
    <name>K9Z2Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219243.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1402"/>
    <dbReference type="EnsemblBacteria" id="AFZ53514">
        <property type="protein sequence ID" value="AFZ53514"/>
        <property type="gene ID" value="Cyan10605_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1402"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1481"/>
    <dbReference type="eggNOG" id="COG1630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059379_0_0_3"/>
    <dbReference type="OMA" id="HEIAYCY"/>
    <dbReference type="OrthoDB" id="626260at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="45332" checksum="2FB98EA7300FFF89" modified="2013-03-06" version="1">MLDLAKLARQMPDMGQEIQKEALKSSQRLEKAIQLLAIVEKDQDTFIKAQKEWSDRLLFTAATPQESITKKVKIPIAPNNHSVFSADGSQIAPSHHEIAYCYLINIGRIMLHYGQNLHPLLDTLPEIYYKSEDLYASRKWGIRTEEWMSYRRTVAEAEVLAEMACTWVNPPGAHFDTPNLAMMDGSLVYWFLETLPVEAREEILNPILKAWESLRQTKIPFVGYVSASRSTSAINFLRFPLCPYDNPNCMAFCGEEVDKTPCQKVEPLRDVNLWTHLLQRGERSAIFRSNSRILDLYGEENHIYFCYLHVGTEIARVEFPQWVAENESLLNQSLSITLAQVDKGFGYPVALAEAHNLAVIKGSDRTRFFALLEEQMIKAGIKNVGVSYKEARKRGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y4</accession>
    <name>K9Z2Y4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218818.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53087">
        <property type="protein sequence ID" value="AFZ53087"/>
        <property type="gene ID" value="Cyan10605_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0957"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1010"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092327_0_0_3"/>
    <dbReference type="OMA" id="VHQVEPV"/>
    <dbReference type="OrthoDB" id="1277822at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="238" mass="27488" checksum="27F91FAC8AB56806" modified="2013-03-06" version="1">MVERYLQTDNQWELDIYNIPIYSVTDASRYLNIPLPTIRTWLNGRKYKTRKGEQNFLPLIQRPSEEMSQLSFTNLVEAHILRVIRTIHNISLDQVRIALDYISKRFDTDHPLATKQFSTDGVDLFLEEVRDLVNVSRSGQLAMKEILLQLLTRVEWDENNLATRLYPELDNTNDDKILIIDPRISFGKPVIKGTGVPTKAIAQLYDAGDSIEDIAENYDCKVIDIKQAILFESYIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z306</accession>
    <name>K9Z306_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52733">
        <property type="protein sequence ID" value="AFZ52733"/>
        <property type="gene ID" value="Cyan10605_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0594"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.626"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139651_0_0_3"/>
    <dbReference type="OMA" id="ANIVIYP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939078" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17454" checksum="0E5C82B93D061B78" modified="2013-03-06" version="1" precursor="true">MWKTLVYSSLLIASANLSLLPYSVQAQTETNNPPASTYQPGFWQPVARVNTEKPISLKIINETGIALDYSFTDETLTPTVLRADDNVTIKSLNPEDSIYLVIYPDLNIPNASRINLQYLVEVTENNMINLTVKQIEDVGKGNRTFNLQPTGAIFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z313</accession>
    <name>K9Z313_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218843.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0982"/>
    <dbReference type="EnsemblBacteria" id="AFZ53112">
        <property type="protein sequence ID" value="AFZ53112"/>
        <property type="gene ID" value="Cyan10605_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0982"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1037"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029746_1_0_3"/>
    <dbReference type="OMA" id="NTIANVW"/>
    <dbReference type="OrthoDB" id="1865124at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="PTHR13194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="CIA30" evidence="2">
        <location>
            <begin position="142"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="37551" checksum="4F85448858D916C2" modified="2013-03-06" version="1">MKIKQLWETLTFFEVIPFFNCFTNFFNISQHKTSPLISTMNFTLICYDHSPLAQETLNNLQQQNIPLRILNTSSFNPNPSEKTEIIKINLLQDSLSPHLLERVDRIFCFPQPGINNLINLINQQLFPGEIILCDLRYGNENQRYIWGAVDDVVMGGVSSSNLFFKENKAIFTGNVSTDNNGGFVSVRSKNFNPPWDLSAYEGIRLRVQGDGNRYKFITRCEGKWDGISYCYSFNTIANVWMTIDIPFKDLIPVFRAKTVNADQFDQTRVYSLQLMLSKFEYDGAYNPTFRAGVFSLEIESIKAYGKPNSPQLILMDNQVDGETMKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z334</accession>
    <name>K9Z334_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218863.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1003"/>
    <dbReference type="EnsemblBacteria" id="AFZ53132">
        <property type="protein sequence ID" value="AFZ53132"/>
        <property type="gene ID" value="Cyan10605_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1003"/>
    <dbReference type="eggNOG" id="ENOG5033GX2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159846_0_0_3"/>
    <dbReference type="OrthoDB" id="1917618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939082" evidence="1">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="14792" checksum="2FEA17C28EFA26F4" modified="2013-03-06" version="1" precursor="true">MLKTNTLFTFSSLLLLTFSGFSVSKEAIAQSSNKFNRQQCIQNLVKDGLKSEDASVWCNYNEQCLVRSQKEGLHAEAAKSVCDCTIKTFRNKYTTQKFREITKKSETDKKIANQLREVGEICFEEILFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z354</accession>
    <name>K9Z354_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218519.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0649"/>
    <dbReference type="EnsemblBacteria" id="AFZ52788">
        <property type="protein sequence ID" value="AFZ52788"/>
        <property type="gene ID" value="Cyan10605_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0649"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.685"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_3"/>
    <dbReference type="OMA" id="YHVEHLR"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="14941" checksum="0F2ADD272C8C57D5" modified="2013-03-06" version="1">MKVSDKINTNTIKEDLIPCTPHSLDSEFIDTFKGQILSSEKAQKMAEFFSLLGDPNRLRILSVLAKQELCVCDLAATLDMTESAVSHQLRTLKAMRLVSYQKRGRKVFYRLLDHHVLELYSSVAEHLDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z391</accession>
    <name>K9Z391_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-on-curing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218908.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1051"/>
    <dbReference type="EnsemblBacteria" id="AFZ53177">
        <property type="protein sequence ID" value="AFZ53177"/>
        <property type="gene ID" value="Cyan10605_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1051"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1112"/>
    <dbReference type="eggNOG" id="COG3654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115697_4_0_3"/>
    <dbReference type="OMA" id="FFVTMTF"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018297">
        <property type="entry name" value="Doc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14776" checksum="F773F8208A871925" modified="2013-03-06" version="1">MSIHWLSMRLVIAIHQEQISEHGGADGLRDKGLLESALIRPQNQYYYHKITNISSLASTYTFSIVKNHPFIDGNKRTGFISGVTFLMLNGSHFTASEVEVVHIIQTLASGRITEEELQQWFVKKSKQMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D8</accession>
    <name>K9Z3D8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="11" type="ordered locus">Cyan10605_1115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1115"/>
    <dbReference type="EnsemblBacteria" id="AFZ53237">
        <property type="protein sequence ID" value="AFZ53237"/>
        <property type="gene ID" value="Cyan10605_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1115"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1179"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_3"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="205"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="356" mass="37987" checksum="89BEC5BBF50E5CF6" modified="2013-03-06" version="1">MATSTMAQNPDKEKALNLVLNQIERSFGKGSIMRLGDAAKMKVETISSGALTLDLALGGGLPKGRIIEIYGPESSGKTTLALHAIAEVQKAGGIAAFVDAEHALDPTYSAALGVDIDNLLVAQPDNGESALEIVDQLVRSSAVDIVVVDSVAALVPRAEIEGEMGDLQVGLQARLMSKALRKVAGNIGKSGATVIFLNQLRQKIGISYGSPEVTTGGTALKFYASVRLDIRRIQTLKKGSEGEYGIRAKVKVAKNKVAPPFRIAEFDIIFGSGISRIGCLLDLAEKTNIVNRKGAWYSYEGDNIAQGRDNAVKYLEENLEIAEAIEEKVKAELEINNVSFGSSGDDSDDDNFDMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D9</accession>
    <name>K9Z3D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218624.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52893">
        <property type="protein sequence ID" value="AFZ52893"/>
        <property type="gene ID" value="Cyan10605_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0760"/>
    <dbReference type="HOGENOM" id="CLU_563507_0_0_3"/>
    <dbReference type="OrthoDB" id="2132801at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="54897" checksum="21EA666E18878387" modified="2013-03-06" version="1">MVTHFSVDTSVNIPATVNDFIKHLSEGFGVSDVYLCGDIDEVRQFILSHLHMVRGIKDVDGERQEGFLKNSVDELIEYISIITLPYLERENQVNLSIVGDTLYGYDSQGIAVSFVNIERLVNYLQQGLPLLAIDGVHVGTSIPHPVGSLINPKILTDKPIYQASAHTAIRQADVGVKEIVGQLWRGNIIGMDMNKISVSRDKNYIMPVMGTAFLWNLIICNGNRPIPTPEETTVDYLLQRKTDCWFPTYTYRCDPEGNCHAARIYEDNLLPSKEIRKEIQDGHCFSIKVAGALRASLYHLNPIKPLIIEPHSYSGFSHEFLNQYVGKSLLPQDWLPLAKKENALRPLVSVLDVQKLGQNGYWTTTQEEAERFYQGFLQELKSHWHELPFIEGIPESMNDVYGYGGGILTRLTQVIEQASYYANTDFESIKTFYEKNILTVEINRLLVQLSEFEDVSCITEEVYLQRCQIVGNAFMAGIKNMLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N3</accession>
    <name>K9Z3N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">PCC 10605</strain>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="191"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="28290" checksum="25713C98AAF4CCE5" modified="2013-03-06" version="1" precursor="true">MKHLNIIISVIFIFVFTLIMFASSLVYEPVQTTDNQYYEYRALHNRDGIGKYYLGREIAKVMGHQEFLWLERPSREAEEQPSKVIEALNLSPDDTIADIGAGSGYFSFRLAQKVPEGLVYAVDVQPEMIDIIDFLAEESPNLPVLPVLGSETSPNLPPESINFALMVDTYHEFNHPREMMENIVKALKPQGKVVLVEYRKENPLIMIKGVHKMSEKQVKKEMEAVGLKWLKTDEFLPQQHYLVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1648</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1648"/>
    <dbReference type="EnsemblBacteria" id="AFZ53754">
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        <property type="gene ID" value="Cyan10605_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1648"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1750"/>
    <dbReference type="eggNOG" id="ENOG5032RS2">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176868_0_0_3"/>
    <dbReference type="OMA" id="VRFWLNA"/>
    <dbReference type="OrthoDB" id="2024081at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012663">
        <property type="entry name" value="CHP02450_Tryp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09493">
        <property type="entry name" value="DUF2389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02450">
        <property type="entry name" value="TIGR02450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="9305" checksum="3F5AC2A93643E7E4" modified="2013-03-06" version="1">MAKKQKFPHLLGSKWTAAQKTWGWRHFQVINRKNEDKWVFAEMMSSCDSQVRFWINAKQLKDRNLWTPGWTPLKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R2</accession>
    <name>K9Z3R2_CYAAP</name>
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        <submittedName>
            <fullName evidence="6">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1738"/>
    <dbReference type="EnsemblBacteria" id="AFZ53841">
        <property type="protein sequence ID" value="AFZ53841"/>
        <property type="gene ID" value="Cyan10605_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1738"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1845"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="TEMGCNH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="PAC"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="201"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="343"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="596" mass="67590" checksum="695018CC9C17C462" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R3</accession>
    <name>K9Z3R3_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218931.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1077"/>
    <dbReference type="EnsemblBacteria" id="AFZ53200">
        <property type="protein sequence ID" value="AFZ53200"/>
        <property type="gene ID" value="Cyan10605_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1077"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_0_3"/>
    <dbReference type="OMA" id="TIFHLHA"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="45787" checksum="EE64DFEB882E2B1F" modified="2013-03-06" version="1" precursor="true">MIASNFFLSLSLNIMNENILLIGYSSQNMASGVSLSFDSLIDGFKLIDYQPEVIYIVDSRKSATYGSFSLTRVKDSLKAIFEALQKIPNQEVIYMTISSSKLGFIRDMMIIWFAWFFKKRVILHLHGGGYKDFYLGQSSLFQKLIRSTLAKSTHIVVLGELLRDQFYFVPDIDGKIKFIPNGLTTNLNTNLAKVKSLPSTDQCLRLLYLSNLIPSKGYLILLDACIKLIKNHGIRLICDFCGDFSLTVVDDKSLDVKKQKEDFFFKIKQAGLEDYIIYHGRVSGEKKEKMLREANFFVLPTFYSWEGQPLSIIEALAFGTPIISTYHKGIPEQVKDEYNGYLIKTNDPQEIIDAILKGIKSPDNYSTLSKNAIKHFQDHFTREVHLKRLISLICEDDNIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X7</accession>
    <name>K9Z3X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inorganic carbon transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218814.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0953"/>
    <dbReference type="EnsemblBacteria" id="AFZ53083">
        <property type="protein sequence ID" value="AFZ53083"/>
        <property type="gene ID" value="Cyan10605_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0953"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1006"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033061_0_0_3"/>
    <dbReference type="OMA" id="DTVWYRP"/>
    <dbReference type="OrthoDB" id="754057at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006007">
        <property type="entry name" value="Inorganic_carbon_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00947">
        <property type="entry name" value="2A73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="459" mass="50994" checksum="0E6545B618F96870" modified="2013-03-06" version="1">MSTLKHSQDEKFFLLNWLKGSLIGNLVGLLSPWRSSSYLLGYSDIITAIFVCLVIISSPFTSNTLVGIILLAGGGFWVLLTVSDIDKNQITPIHLCIFAYWLISVAATAFSPLKMAALSGLVKFTLYLLLFALASRVFAKTKMRALIMGTYLLVSLIVSAYGVRQQFIGVKPLATWTDPTSPLADTTRVYSFLGNPNLLAGYLIPAVAFSVVALIVWKTKPQKILAGFALVINVACVYFTGSRGGWLALIGTGIVFLLGFKFWWNEYLSPFWRKWLIPTVITSFLLLVGVAMIFVEPLRIRIFSLFSWRGDSSNNFRINVWISALQMLQDYPLIGIGPGNEVFNQIYPLYMQTKFTALSAYSIFLEIALETGLIGLFSFLAVIVTTFKRGMVLIKKMKPSNDLQAIWILGAIASLAGLATQGLFDTVWYRPQINTLWWLCVAMVAAVYSLKSETDNHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z403</accession>
    <name>K9Z403_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218839.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0978"/>
    <dbReference type="EnsemblBacteria" id="AFZ53108">
        <property type="protein sequence ID" value="AFZ53108"/>
        <property type="gene ID" value="Cyan10605_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0978"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1032"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_3"/>
    <dbReference type="OMA" id="NPDGCTM"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36700" checksum="E59402E599B9CCAF" modified="2013-03-06" version="1">MQNLRTPVINYYQVLGISSDASPEDVKKAFRTLARRYHPDVNPGDQNSEEMFKQINEAYDILSDYTKRQQYDSQFLGGKRRFVGSQTKKRPSNGFPFPNANIGGFWQDNVRSSNGASSGNKNSTYRPNPPNIGDFRPGTTKTIKSTPSPRTQPKDIEAKLTLPLTKAYEGGRERIRLEDGRSLEVDMPPCMYHGQKIRLKGQGIRGGDLYLKILIEPHPFFTLQGSDISCEVPLTPSEAIVGGAIEVPTIDGLVKMNVPAGVKSGQRLKLANKGYPNIRGERGDQLVIINIVIPPEVSEEEKELYAKIREVEQFKPRQDFIDLYTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z404</accession>
    <name>K9Z404_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1179"/>
    <dbReference type="EnsemblBacteria" id="AFZ53300">
        <property type="protein sequence ID" value="AFZ53300"/>
        <property type="gene ID" value="Cyan10605_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1179"/>
    <dbReference type="HOGENOM" id="CLU_3215168_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="44" mass="5245" checksum="1685582A46C8BFD2" modified="2013-03-06" version="1">MTTQTIDLTEMILTKIKDLPLEQQLKKINRMEKELQVYLRIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z464</accession>
    <name>K9Z464_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219711.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1887"/>
    <dbReference type="EnsemblBacteria" id="AFZ53986">
        <property type="protein sequence ID" value="AFZ53986"/>
        <property type="gene ID" value="Cyan10605_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1887"/>
    <dbReference type="HOGENOM" id="CLU_133778_0_0_3"/>
    <dbReference type="OMA" id="WIPSAWT"/>
    <dbReference type="OrthoDB" id="1819809at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12479" checksum="591EB2EBD20533F4" modified="2013-03-06" version="1">MKEDPQDKLDKFQLSLYLMPLFGPIWSLVNLNYKSNLEQKEKKTARLSLKWGLIWLIVYGSLWMGGNITSDIWAVRLLYLNGVVTTIYFLMCFILISSVWTQRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z487</accession>
    <name>K9Z487_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-3',4' desaturase CrtD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219286.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1446"/>
    <dbReference type="EnsemblBacteria" id="AFZ53557">
        <property type="protein sequence ID" value="AFZ53557"/>
        <property type="gene ID" value="Cyan10605_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1446"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1534"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_4_2_3"/>
    <dbReference type="OMA" id="LWLCGDS"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014104">
        <property type="entry name" value="Myxoxanthophyll_desat_CrtD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02733">
        <property type="entry name" value="desat_CrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="498" mass="55115" checksum="36FAE7A3BF2A3520" modified="2013-03-06" version="1">MGHKEKVIVVGAGIGGLTAGALLARYGYDVTIYDQAIVSGGCASTFKRKGFIFDVGATQVAGLEVGGIHHRVFQELGVDLPPATNCDPACAVFLPQEKQPIMVWRNREKWKMEREGHFPNSGRFWELMRILFEASWRFQARDPILPPRSLWDFGQLLQAIRLDTFVTAPFTFMTVADALRLLGLAHDKRLKTFLDMQLKLYSQVDTEETALLYAATALSVSQEPQGLYHLQGSMQVLCDRLEEGLNKYGGKLLMRHKVDKIHTKKGKAVGVRVKNLKTGEIKEEKADYVIGNVTVNNLVTMTDNISRGYAQRVKKLPPASGAFVVYLGVDESAIPSNCPPHLQFLYDYEGEIGEINSLFVSVSKPGDGRAPEGKATIIASSFTDVNRWWNISQAEYEALKLNYTQDAIARLAEYFNLTPETIIHQESATPVTFANYTAREKGIVGGIGQRINTFGPFGFANRTPIKNLWLVGDSTHPGEGTAGVSYSALTVVKSIMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K4</accession>
    <name>K9Z4K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219047.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1199"/>
    <dbReference type="EnsemblBacteria" id="AFZ53318">
        <property type="protein sequence ID" value="AFZ53318"/>
        <property type="gene ID" value="Cyan10605_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1199"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1265"/>
    <dbReference type="eggNOG" id="COG1895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151247_2_1_3"/>
    <dbReference type="OMA" id="YYAMFYA"/>
    <dbReference type="OrthoDB" id="1694197at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="14661" checksum="4913EE28F444677E" modified="2013-03-06" version="1">MKNEQKLLLEKAQESLRASKILLENQLPDFAVARAYYTMFYIAEAFLLKQDLTYSSHSAVIAGFGREFAKTKRIPVEYHRYLIEAQQKRTEADYNLKPNITLQEAENIINKAQNMLDFTNNNIDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M8</accession>
    <name>K9Z4M8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF sensor signal transduction histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219269.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1429"/>
    <dbReference type="EnsemblBacteria" id="AFZ53540">
        <property type="protein sequence ID" value="AFZ53540"/>
        <property type="gene ID" value="Cyan10605_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1429"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1510"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405850_0_0_3"/>
    <dbReference type="OMA" id="RQEAHRY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033415">
        <property type="entry name" value="CHASE6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17150">
        <property type="entry name" value="CHASE6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="424"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="655" mass="74584" checksum="8D9C27F0F02F7955" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M9</accession>
    <name>K9Z4M9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uvrA</name>
        <name evidence="17" type="ordered locus">Cyan10605_1234</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219082.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1234"/>
    <dbReference type="EnsemblBacteria" id="AFZ53353">
        <property type="protein sequence ID" value="AFZ53353"/>
        <property type="gene ID" value="Cyan10605_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1234"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1302"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_3"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="627"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="663"/>
            <end position="670"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="962" mass="106523" checksum="2F4F9FD7D24DF57E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S1</accession>
    <name>K9Z4S1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2055"/>
    <dbReference type="EnsemblBacteria" id="AFZ54144">
        <property type="protein sequence ID" value="AFZ54144"/>
        <property type="gene ID" value="Cyan10605_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2055"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2184"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_7_3_3"/>
    <dbReference type="OMA" id="GRTTFPQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03418">
        <property type="entry name" value="GRX_GRXb_1_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011900">
        <property type="entry name" value="GRX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02181">
        <property type="entry name" value="GRX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="10909" checksum="CC547B168115DE27" modified="2013-03-06" version="1">MLTVNQNRVIMSAKVEIYTWSSCPFCLRAKALLREKQIEFTEYCIDGDNAARMAMTERANGRSSLPQIFIDDQHIGGCDDIYALDRAGKLDQILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V2</accession>
    <name>K9Z4V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thymidylate synthase (FAD)</fullName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1656"/>
    <dbReference type="EnsemblBacteria" id="AFZ53762">
        <property type="protein sequence ID" value="AFZ53762"/>
        <property type="gene ID" value="Cyan10605_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1656"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1758"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155920_0_0_3"/>
    <dbReference type="OMA" id="FMDLRAK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="30392" checksum="44F6BABABA75A632" modified="2013-03-06" version="1">MEMIDNLEMLDPLFAVEVLSKCDRPNLLCYLAMHQDYSEDFVYSEMSKLANYSEAELGDRIVRNCVNKSHWGILEHPSITFNVINFPHSVMVQARTHRVGVSFDCQSQRYTCKRILRLAQQIEETPEDAINLIEKVFYFRAVAHYFDREGNKYFYSPSARNQDILFTQKAVLYYAEKVNQQGYAPEHARDLLTQNLRQHFVVSFNARSLLHFCDLRLPKDAQPEIRNLAELIFEHFQKWMPEVANVYAKKRMGKNLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V8</accession>
    <name>K9Z4V8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="3">NDK</shortName>
            <shortName evidence="3">NDP kinase</shortName>
            <ecNumber evidence="3 5">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk</name>
        <name evidence="7" type="ordered locus">Cyan10605_2080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">(Microbial infection) Catalyzes the phosphorylation of dZDP to dZTP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dZDP = ADP + dZTP</text>
            <dbReference type="Rhea" id="RHEA:67644"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:172929"/>
            <dbReference type="ChEBI" id="CHEBI:172931"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219894.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2080"/>
    <dbReference type="EnsemblBacteria" id="AFZ54169">
        <property type="protein sequence ID" value="AFZ54169"/>
        <property type="gene ID" value="Cyan10605_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2080"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2210"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_3"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="16861" checksum="F4C1CD785104B06F" modified="2013-03-06" version="1">MERTFIMIKPDGVQRNLVGEIIKRFEQKGFTLAGLKLMQVSRELAEKHYDVHKERPFFNSLVEFIVSSPVVAMVWQGEGVVASARKLIGATDPLAAEPGTIRGDFGIEIGRNIIHGSDAIETAQREISLWFSEEEICSWENSMKPWLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z514</accession>
    <name>K9Z514_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="21234" checksum="EC1D0601569E8262" modified="2013-03-06" version="1">MESSIYPISPLIKITLLNLYFALTIPLPFLLKTTSLNFPIWLLSLLIGLGAIAIFAILSERVIVDNEGIAVTYPQWVKWLWRKGWHLSWREIDSLKMRTTGQGGLVYYFVSKNRDKAYLLPMRIAGFAKMVQQVQNKTNIDTTDIRPLAQPWMYIFLFFFTFFLWLVDIWTIYQIQFSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z545</accession>
    <name>K9Z545_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
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        <property type="gene ID" value="Cyan10605_2215"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
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            <end position="261"/>
        </location>
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            <begin position="270"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="637"/>
        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="654" mass="73998" checksum="8027801B43927EF6" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z564</accession>
    <name>K9Z564_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="755178.Cyan10605_2235"/>
    <dbReference type="EnsemblBacteria" id="AFZ54321">
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        <property type="gene ID" value="Cyan10605_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2235"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2376"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1371190at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="43970" checksum="040315988625BDB2" modified="2013-03-06" version="1">MTYDIAIIGGGIVGLATAMNLQQKYPQKKIILVEKENHCATHQTGHNSGVIHSGVYYQPGSYKAKLTTQGNRALVEFCQTHNIKYDVCGKLIVACKEKELSQLENLYQRGLQNGIAVTKISREEAKEIEPYVNCIQAIKVPTAGIVDYKEVAKKYAEIFCNIGGEIRLNTKVVNLKYQDSQHIIITNQGEITSKYLVNCAGLYSDKIAILGGINPKMKIIPFRGEYYELKPEKRYLVKHLIYPVPNPDFPFLGVHFTRLIDGNIHAGPNAVLSLKREGYKKTDFALGEFWETVTYSGLWKLVSKYYEEGIEEIIRSFSKTAFVRSLQTLIPEVQEDDIIPSPAGVRAQALNQDGTLVQDFALLPTENALHVCNAPSPAATASLKIGEVISQNVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z587</accession>
    <name>K9Z587_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220070.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2261"/>
    <dbReference type="EnsemblBacteria" id="AFZ54346">
        <property type="protein sequence ID" value="AFZ54346"/>
        <property type="gene ID" value="Cyan10605_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2261"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2401"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_3"/>
    <dbReference type="OMA" id="NVLRKTQ"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="22911" checksum="D61BFB71FC0EA1C0" modified="2013-03-06" version="1">MLKILLVEDDELFRLGLSVRLQQETDLHIVAEAEDGETAVNLTNRHPLDLVLLDIGLPRMSGLEACYKIKSNHPKLAILALTSHSEPSLINRLIEVGIQGYCLKGIPAETLILAIRSVVAGASWWDSKATQEIQSAFTSPSNSILDALTEREREILTLMAQGKSNQEIAKMLYITSGTVRVHTHSMIQKLGVCDRTQAILLFQNLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B4</accession>
    <name>K9Z5B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219327.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53598">
        <property type="protein sequence ID" value="AFZ53598"/>
        <property type="gene ID" value="Cyan10605_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1487"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1579"/>
    <dbReference type="eggNOG" id="COG0390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076147_1_0_3"/>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="OrthoDB" id="1882150at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="258" mass="28706" checksum="E39E7710C0608F3F" modified="2013-03-06" version="1">MEIIELDFIDLLWAWGLILMAISLSIWQKLGFEGQFLLAAGRSLLQLMFLGYILEFIFVIDNPVAVVAIILIMITIAAIVARNRISKKIPRLLQTVWLGLFFSSSFVVAYSIVFIIQPERWYNPQYLIPLVGMILGNTLNGASLAGERLANMIKNNRLEIETHLCLGATGRNAIASYRLDAIKVGLIPIINSMMVVGMVSLPGMFTGQVLAGNSPLSAASYQILILFMIALANLITILIITEGVYRHFFNARQQFVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E2</accession>
    <name>K9Z5E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1861"/>
    <dbReference type="EnsemblBacteria" id="AFZ53962">
        <property type="protein sequence ID" value="AFZ53962"/>
        <property type="gene ID" value="Cyan10605_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1861"/>
    <dbReference type="HOGENOM" id="CLU_2381365_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="11316" checksum="36CBF71D3ADF2A52" modified="2013-03-06" version="1">MLTGYYYEYDSLTYDIISLFSSICSPRYTIHHVARIYGKSHNRLLNEEFLHNYFYAEYIAGIDVIENRMENLIIFSLEDNINIDKYMNTQLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K7</accession>
    <name>K9Z5K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220195.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2389"/>
    <dbReference type="EnsemblBacteria" id="AFZ54471">
        <property type="protein sequence ID" value="AFZ54471"/>
        <property type="gene ID" value="Cyan10605_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2389"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2536"/>
    <dbReference type="eggNOG" id="ENOG5031YA1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118481_0_0_3"/>
    <dbReference type="OMA" id="NWDTDFA"/>
    <dbReference type="OrthoDB" id="1695288at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17255" checksum="1C2FB24C7E6597F5" modified="2013-03-06" version="1" precursor="true">MFSPLILLSFFSLFFCSLIVPIRAETCKPLPLVGGEGSTVTKTVSQPTIPTRFGNITNSNWNTDWAVPGGESFKRYVVTVTSKDDNSFDIRMYLKYSDQTADEFFNEEGYTVNPDQPLKVSANPRKSTQPYQVNLFVNGVASFGKTYTATVMGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N5</accession>
    <name>K9Z5N5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220225.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2419"/>
    <dbReference type="EnsemblBacteria" id="AFZ54501">
        <property type="protein sequence ID" value="AFZ54501"/>
        <property type="gene ID" value="Cyan10605_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2419"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2563"/>
    <dbReference type="eggNOG" id="ENOG502ZBP7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530813_0_0_3"/>
    <dbReference type="OMA" id="QFVGYSR"/>
    <dbReference type="OrthoDB" id="1722016at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="20954" checksum="BF4895134D47F745" modified="2013-03-06" version="1">MTISSSLPKLNDLSFLPYLDDTGKISSELEGKIGIYAIFDQNKNLRYIGYSRNLFLSLKQHLIRQSDNCSWLKLYSFDRPNRTILEEIKQNWLAENQHIPEGNGEKENLWTQPIDAKLTMTMGEKEEYQELDEISKVKFLKKIARKLEEDIKEKLTLKGVTMEIRFNPKLKEEGLLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P2</accession>
    <name>K9Z5P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative type II DNA modification methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220234.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2430"/>
    <dbReference type="REBASE" id="58399">
        <property type="entry name" value="M.Cap10605ORF2430P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54511">
        <property type="protein sequence ID" value="AFZ54511"/>
        <property type="gene ID" value="Cyan10605_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2430"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324584_0_0_3"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="24026" checksum="0B9F279D8E39A037" modified="2013-03-06" version="1">MIISKELISSLKIENSNEIGNLISKQNDVSTINFILENLGKLPSDFDGKFLFNLLNHPNKQVRVNVIKTIGKLAYKYNLDYFKKLFQEEKETIVKREIISTIGRQRDLKNVDFLLSVLEDEDPKIVCQAIRSLIIFDDIKKVSQELKKLINHPNEMVRTAIYKKYFSNEENNKSKLPHTKTYEFLKNVVVNGIDGFVQHKSSLPIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z606</accession>
    <name>K9Z606_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220297.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2493"/>
    <dbReference type="EnsemblBacteria" id="AFZ54574">
        <property type="protein sequence ID" value="AFZ54574"/>
        <property type="gene ID" value="Cyan10605_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2493"/>
    <dbReference type="eggNOG" id="ENOG5032UPK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096791_0_0_3"/>
    <dbReference type="OMA" id="SEHERYY"/>
    <dbReference type="OrthoDB" id="1759249at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="25946" checksum="863F9634DC5ED934" modified="2013-03-06" version="1">MTKVEIICLANSKKHGGRCIAGIRTDEKGWIRPIGRNDDHGALFPEDYILIDGSEPRKLSVIEIGISTPKPKPYQPENWLIETIPWRLVSNSLNQSHLRLIKNAFFQGDNLFGTTSDRIPYIQLEQYPAKSSLEIIQPVGVKWVIKNNYSGNRQIRAIFYLHNVEYDLVVTDLDWLKKLAQFDLGYYTSEDIGLPQQVKFLFTISLGVPYNGDCYKLVAAVIPYFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C0</accession>
    <name>K9Z6C0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ordered locus">Cyan10605_2201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220012.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2201"/>
    <dbReference type="EnsemblBacteria" id="AFZ54287">
        <property type="protein sequence ID" value="AFZ54287"/>
        <property type="gene ID" value="Cyan10605_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2201"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2339"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_3_3"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="23687" checksum="8CCB9DE30E20C966" modified="2013-03-06" version="1">MAHLEIEDLGLLPYKIAWEYQQSIVQQKLNNPSFPDKLILVQHPPVYTLGTGATTENLKFDLNSFSGEIHRIERGGEVTYHYPGQIVAYPILNLRSYQQDLHWYLRQLEEVIICLLAKYDVKAERIKGLTGVWVDNTKIAAIGIKVKRWVTMHGFALNVNGDLSGFNQIIPCGIKDKGVTKLSNFLPSISVEDVKPELVKTFISIFECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F5</accession>
    <name>K9Z6F5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220052.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54327">
        <property type="protein sequence ID" value="AFZ54327"/>
        <property type="gene ID" value="Cyan10605_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2241"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2382"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_4_0_3"/>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="31962" checksum="75B3EE77D4130DAD" modified="2013-03-06" version="1">MNIILQSVLPVAFIIIIGYVAGKKLSLERSTLSQLTVYILAPALVTDSFYRNSMGGDVTLRFLLAYGLISVILYGGIILIGKVIKLSSENHRSLFAILLCPNNGNMGLSITAFALGEGGLERAVIYMIGSSIVLFGVLPAVLKGESIIKGIKMTFRLPLIWAMILGVSLHLAHITLPFNLGKSIEWLGMSSIPIALLILGMQLTNTRFQFDFIHFLISLGKLAIAPLIAYGVGKIMGLEGLDLQVLVLQTAMPTAINTAVMMQEFGGDITMVSRTIILSTLMSFITIPMVMFLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H4</accession>
    <name>K9Z6H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219733.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1910"/>
    <dbReference type="EnsemblBacteria" id="AFZ54008">
        <property type="protein sequence ID" value="AFZ54008"/>
        <property type="gene ID" value="Cyan10605_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1910"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_1_3"/>
    <dbReference type="OMA" id="HATVHEF"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="32220" checksum="F3928665E9654E0B" modified="2013-03-06" version="1">MEIQEKKIKVGNFEWFYREMLPPQENNKVPVILLHGLFSQSFSWLEMMPSLAEYGYRAIAPDWLGWGFSDIPEKREFGYKPDNFIEALKDFIETLELEKVSLIIQGFLGTIGIQYALKYPEKIDHLVILNAPITTEAKLPWQIAQCGFPLLGDMVTQDPLIVDRTLEKGSGFVISDNNLALYRKPIVTSSAAGRMLVTIVKNLQLKQTTKEIETGLKTWEKPCLIIWGNEDPWLEIDSVENLIKTNNKLKLTPLPEAKHYPQEHFSEEISPLIINFLGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J8</accession>
    <name>K9Z6J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220096.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2288"/>
    <dbReference type="EnsemblBacteria" id="AFZ54372">
        <property type="protein sequence ID" value="AFZ54372"/>
        <property type="gene ID" value="Cyan10605_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2288"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2430"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050673_0_0_3"/>
    <dbReference type="OMA" id="GYQRALW"/>
    <dbReference type="OrthoDB" id="844428at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="32886" checksum="AB411225E5EC4724" modified="2013-03-06" version="1">MSKAIYELVNELPQNNITTLALKSLDKFIPGQWENITNFEEMIRQVTGENDEEMIQKIGDRAVWLFNDKTQGYQNALWLYQTVDKTDYALGAAALANKVGEKIKLLGFLNRLTPNNEKAQAIDLAIKLVVEVVAFCQINGLPGDSISDFVKALGEYEKEALIRMGGLVCFDGLIPFGGDFILQIESTLNNLSGKELSNNSSFSQVSRLIPGDNPAGQLQFIHDSFSAVKGWMTGFVANHSLTRDKLLSSLHNFIEFSEDQFDYVAAFLDMSTNYFEHTGTQSIAKSLISRAMFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K2</accession>
    <name>K9Z6K2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220482.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2685"/>
    <dbReference type="EnsemblBacteria" id="AFZ54759">
        <property type="protein sequence ID" value="AFZ54759"/>
        <property type="gene ID" value="Cyan10605_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2685"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2850"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053780_0_0_3"/>
    <dbReference type="OMA" id="GRKKCPY"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07397">
        <property type="entry name" value="MPP_NostocDevT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027629">
        <property type="entry name" value="DevT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35769">
        <property type="entry name" value="PTHR35769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04168">
        <property type="entry name" value="TIGR04168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="33689" checksum="E2031E50261970B2" modified="2013-03-06" version="1">MTDKIIKIAVIGDVHDLWNEFDHEALEFLQVDLVLFVGDFGNESIPLISRIAQLNIPKAIILGNHDAWFSATEWGRKKCPYDRTLEDRVQQQLDILGKSHVGYGYLDFPELDISVVGSRPFSWGGSKWKCEEFYREKYAIENFHQSSDKIIASVNKTQAQQIIFVGHNGPFGLGANPEDTCGRDWKPLGGDFGDPDFQEAIKYTQELGKNVPLVTFGHMHHSLRHTKDRLRTIINQDEHKTIYLNAASTPRIQEIEGQKIHKFSLVTLDARIVTKIDLIGISEKMKIKEAINLYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L6</accession>
    <name>K9Z6L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cellular thylakoid lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family. PetJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219915.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2101"/>
    <dbReference type="EnsemblBacteria" id="AFZ54190">
        <property type="protein sequence ID" value="AFZ54190"/>
        <property type="gene ID" value="Cyan10605_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2101"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2233"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_1_0_3"/>
    <dbReference type="OMA" id="CAGCHIN"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031979">
        <property type="term" value="C:plasma membrane-derived thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023655">
        <property type="entry name" value="Cyt_C6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34688">
        <property type="entry name" value="PTHR34688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="12916" checksum="8D5F695ADE3EB954" modified="2013-03-06" version="1" precursor="true">MTKYLTIIISLILTINLLFIFPVNAETVINNQPQKIFELNCAGCHPNGNNIIRRGKNLKLKALHRNGYDSVEAITQIVSNGKNNMSAFSNRLSEREIKEVAEYVLQQAENNWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M5</accession>
    <name>K9Z6M5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="11" type="ordered locus">Cyan10605_2318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220126.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2318"/>
    <dbReference type="EnsemblBacteria" id="AFZ54402">
        <property type="protein sequence ID" value="AFZ54402"/>
        <property type="gene ID" value="Cyan10605_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2318"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2463"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_3"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="10">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="177" mass="20330" checksum="02084DF3932BCD62" modified="2013-03-06" version="1">MQCPSCHFNQTKVIESRTTEKAQSIRRRRECLQCHHRFTTYERIEFVAITVIKKDGSTESFDRSKVLRGIVRACEKTGIESELLDSIVDNLESEIENQFPREITSKQIGNLVLKQLSQISQVAYIRFASVYENFTSIEDFVATLKKLQNSPENSGNNPEPQSPISENENKKNQTTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V2</accession>
    <name>K9Z6V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220643.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2854"/>
    <dbReference type="EnsemblBacteria" id="AFZ54921">
        <property type="protein sequence ID" value="AFZ54921"/>
        <property type="gene ID" value="Cyan10605_2854"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2854"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3033"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_10_3"/>
    <dbReference type="OMA" id="LADEMQD"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="433"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="677"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="827"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="948" mass="108720" checksum="9DD69ACCCA55AC75" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z701</accession>
    <name>K9Z701_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219888.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54163">
        <property type="protein sequence ID" value="AFZ54163"/>
        <property type="gene ID" value="Cyan10605_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2074"/>
    <dbReference type="HOGENOM" id="CLU_1746586_0_0_3"/>
    <dbReference type="OrthoDB" id="2220415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="16439" checksum="CEC0CAE75E98AE3A" modified="2013-03-06" version="1" precursor="true">MNNCQKLLQSILSLHQSLFSLLFLSSLFLLTVTTKSISARPLCYLIDANGNQINLSGICGQSKKTAIIQERQPPTPPALPQNGQSNVNPNQTNTTPPENSANTENAIPNSQNTADAQKEEEIDTSEFPPAQRKIPLLQNQRKEQITEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z713</accession>
    <name>K9Z713_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2924"/>
    <dbReference type="EnsemblBacteria" id="AFZ54986">
        <property type="protein sequence ID" value="AFZ54986"/>
        <property type="gene ID" value="Cyan10605_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2924"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3111"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_3_0_3"/>
    <dbReference type="OMA" id="NFAQMVG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="127" mass="14511" checksum="C2920FC1FF25B5A6" modified="2013-03-06" version="1">MLPILYFSLLDSSCLTLEKSNVIIESKLIITQNMVLNETEVRQKLANYPNWVTSGQSINTTYKFKDFIQAVEFVNRLVEPAERAGHHPDIEISYNKVTIHLTTHDAGGITQKDFDLAEEIQRIIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z739</accession>
    <name>K9Z739_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma 70 subunit, RpoD subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220109.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2301"/>
    <dbReference type="EnsemblBacteria" id="AFZ54385">
        <property type="protein sequence ID" value="AFZ54385"/>
        <property type="gene ID" value="Cyan10605_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2301"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2444"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_3"/>
    <dbReference type="OMA" id="MNERPMT"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017848">
        <property type="entry name" value="RNA_pol_sigma_RpoD_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02997">
        <property type="entry name" value="Sig70-cyanoRpoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="255"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="36983" checksum="D6A551D1652F5859" modified="2013-03-06" version="1">MQALPKNIDTIRVYLKEIGRIPLLTKEEEIVLAKQIQELVALEKKRETLKKKLEREPSKKEWAEAAKISEKNLDIKISRGEKAKRKMVEANLRLVVSIAKKYLKHNLDLLDLIQEGTIGMQRGVEKFDPKKGYRFSTYAYWWIRQAITRAIAEKSRAIRLPLHITEKLNKIRQTQRKLSEEKGRPATIAELSEALELTTEQVRDYLGKARQPLSLDLKVGDNNDTELGELLEDKGQSPEDFTDYSCLQFDLRRMMSDLTQQQQDVIRLRYGLDDGKPLTLSKIGTILNISRERVRQIEREALTKLRKRKEVIEEYIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z751</accession>
    <name>K9Z751_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219918.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2104"/>
    <dbReference type="EnsemblBacteria" id="AFZ54193">
        <property type="protein sequence ID" value="AFZ54193"/>
        <property type="gene ID" value="Cyan10605_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2104"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2237"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_1_3"/>
    <dbReference type="OMA" id="FWKIEIS"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16316" checksum="73B209A588330AEF" modified="2013-03-06" version="1">METPKKIFLPDEESTKKLGKEFAQKLTPNSVLLLQGNLGAGKTTFIQGLGEGLGISEPIVSPTFTLINEYLEGKIPLYHIDLYRLNPEQVKHLHLQNYWEGIEVEAGITAIEWSDLLPQLPPHYWQIILELTPDSSRNAFITYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z753</accession>
    <name>K9Z753_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220295.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2491"/>
    <dbReference type="EnsemblBacteria" id="AFZ54572">
        <property type="protein sequence ID" value="AFZ54572"/>
        <property type="gene ID" value="Cyan10605_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2491"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2640"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_2_2_3"/>
    <dbReference type="OMA" id="CSEHLPH"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="SSF47031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="17232" checksum="FA85B25E6478560F" modified="2013-03-06" version="1">MDLFTIGFTQTSAEEFFESLKKNHIKTLIDVRLNNSSQLAGYAKKNDLKYFLKALCDIHYVHILDLAPTKEMLDQFKKQKNMSWIEYEQSYLNLIDNRKIEKKLSPELFENGCLLCSEKKPHHCHRRVLAEYLNEKWGDIRIKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B8</accession>
    <name>K9Z7B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220758.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2979"/>
    <dbReference type="EnsemblBacteria" id="AFZ55039">
        <property type="protein sequence ID" value="AFZ55039"/>
        <property type="gene ID" value="Cyan10605_2979"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2979"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3173"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965474_0_0_3"/>
    <dbReference type="OrthoDB" id="1753304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="34102" checksum="BDB8F41E16D862DF" modified="2013-03-06" version="1">MNKYNRLKNFRHDTYEMLVKSKDATFELMDSIMTRENARSLAQFSLSPFFQRQWCSTYEAIEDSRPNGNKLMKRYTQEIDTLEYTLLGIDHTQWECKDSPTMKDRGYQYSHSSLNSSVVGQGYSTIAWLPPLKEKKTGSLHRPLWLIWVGEEFLSLEYIWSQYKRRFGLEHWYRFAKQRLHWTLPNFRTPDRCQRWSNLIVNITWQLWLSKDLVQEHHLPWQKPQQNLTPGRVALSMTSLLIEIGSPTLSPKSRGKSHGWPQGGKRNKAKVYPTIKKQQSKSKKRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E9</accession>
    <name>K9Z7E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220788.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3009"/>
    <dbReference type="EnsemblBacteria" id="AFZ55069">
        <property type="protein sequence ID" value="AFZ55069"/>
        <property type="gene ID" value="Cyan10605_3009"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3009"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3206"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_3"/>
    <dbReference type="OMA" id="FVWTVTH"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="262"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="506" mass="56935" checksum="ACF0DC370784F84E" modified="2013-03-06" version="1">MKEELNTLIKAQYPLIYLVTSEEERAEKAIADIVAESNDKNPPRIYAWTVTRGLVELDNPNGSSVQHNTVSPEAAIEWVVRQKEAGIYIFKDLHPYLESPPVTRWLRDAIASFKGTDKIIILMSPYQQTPLELEKDLVVLDFPLPQASELDQVLEKALKRARGKQLQPEIKERLRRAALGLTIDEAEKVYRKALVKAGKLSDEEVEIVLSEKKQLIRRNGILDYIEEDETINGVGGLEELKHWLTQRSQAFTEKARDYGLPQPKGMLILGVPGCGKSLIAKTTSKLWGLPLLRLDMGRVYDGSMVGKSEANLRSALKTAESISPAILFIDELDKAFAGSAGSGDSDGGTSSRIFGSFLTWMQEKQSPVFVMATANRLEKLPGEFLRKGRFDEIFFVDLPNAQEREAIFHIHLKKRRHDIDRFDLDQLAKVSDGFSGAEIEQAIVAAMYEAFAQEREFTQLDIIAAIKATLPLSRTMTEQVSALRDWARQRARPASSSIAEYQRMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I9</accession>
    <name>K9Z7I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3057"/>
    <dbReference type="EnsemblBacteria" id="AFZ55114">
        <property type="protein sequence ID" value="AFZ55114"/>
        <property type="gene ID" value="Cyan10605_3057"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3057"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3258"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137907_0_0_3"/>
    <dbReference type="OMA" id="FRINCAG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="14061" checksum="298EC70C88E09BB6" modified="2013-03-06" version="1">MNNQLLETQLNDNSTQNKTTGNILAIVIIVLISLTIWWLFPISDPYVQEVLSLEGNKTRGEAIFQVNCAGCHGLNGAGNVGPSLLNVTKHKSDSQIIKQVISGKTPPMPKFQTSTEDMADLLNYLHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J7</accession>
    <name>K9Z7J7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2474"/>
    <dbReference type="EnsemblBacteria" id="AFZ54555">
        <property type="protein sequence ID" value="AFZ54555"/>
        <property type="gene ID" value="Cyan10605_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2474"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2623"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_3"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="OrthoDB" id="1528139at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="18335" checksum="ED928FEB0FE71FBD" modified="2013-03-06" version="1">MSIPHPDKKFISVNCAIITVSDSRTVVNDESGQIMQELLIKSGHKIVNYIIIKDNKELIEITLKNIAKNDNVHCLIFNGGTGISNRDHTYDVLANLLDKTLSGFGEIFRFLSYQEIGSRAIASRALAGVYQGKLVFSLPGSTGAVKLGLEKLILPELNHLWTQINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K6</accession>
    <name>K9Z7K6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220102.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2294"/>
    <dbReference type="EnsemblBacteria" id="AFZ54378">
        <property type="protein sequence ID" value="AFZ54378"/>
        <property type="gene ID" value="Cyan10605_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2294"/>
    <dbReference type="eggNOG" id="ENOG50333A6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432379_0_0_3"/>
    <dbReference type="OMA" id="NIESSGW"/>
    <dbReference type="OrthoDB" id="1823206at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="21183" checksum="716B30BEAA9466DC" modified="2013-03-06" version="1" precursor="true">MKKNNLISVLIMGFIASQLIPFSDSIKAETVSEKKPLLLVQETQTGLTEDTLTQIMTEIEQAEAEENIAGILEYLAPYVITSITVEIDNQKITTFVEGKDDHEGFLNDSFKKVKGKKIISSYTTTKINDSGEMALLTRVRAREVDTETGNRYLSLSTDKIRFAMIDNEPKIINIESSGWLEPISDQAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L1</accession>
    <name>K9Z7L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220107.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2299"/>
    <dbReference type="EnsemblBacteria" id="AFZ54383">
        <property type="protein sequence ID" value="AFZ54383"/>
        <property type="gene ID" value="Cyan10605_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2299"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_2_0_3"/>
    <dbReference type="OMA" id="WEFNQIV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17463" checksum="C1D6A2D05AD75159" modified="2013-03-06" version="1">MLEENQKLIFTWDEFWQYCQKVTEKIIQENQEYSQIISILRGGFYLGDYLSRRLNIPLSAIVAKSYSEQNQQGNLLLGQLSCIEPPTNRVLLVDDLLDTGVTMIAVKKALENQWQVKVDTAVIWQKSHSQCQADYFCEITPASVWIVQPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N4</accession>
    <name>K9Z7N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220900.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3130"/>
    <dbReference type="EnsemblBacteria" id="AFZ55181">
        <property type="protein sequence ID" value="AFZ55181"/>
        <property type="gene ID" value="Cyan10605_3130"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3130"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3336"/>
    <dbReference type="eggNOG" id="COG4178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_6_0_3"/>
    <dbReference type="OMA" id="IPRWNSK"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="361"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="570" mass="64655" checksum="9E7CF9FDDDF1ED81" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R6</accession>
    <name>K9Z7R6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220167.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2360"/>
    <dbReference type="EnsemblBacteria" id="AFZ54443">
        <property type="protein sequence ID" value="AFZ54443"/>
        <property type="gene ID" value="Cyan10605_2360"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2360"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2506"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119429_0_0_3"/>
    <dbReference type="OMA" id="SERHYYT"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="23986" checksum="F84EDB6F042B336A" modified="2013-03-06" version="1">MYEYHKLTPQQRLELVQERLKRGFPPHSPPHPIQIEGFYLLTIACYQHQKILNNSSRRQQLLNLLFEKCIHEAIDIRGWVILVNHYHLLVYLPNLSILTSIFKAIHGVTSYQWNLEDNQRGRKVWYRFSDRAIRSERHYYTTLNYIHYNPVKHNYVNSPYDWLESSVHWYLEEKGREWLRDSWVKYPVRDCGKGWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T2</accession>
    <name>K9Z7T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220903.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3133"/>
    <dbReference type="EnsemblBacteria" id="AFZ55184">
        <property type="protein sequence ID" value="AFZ55184"/>
        <property type="gene ID" value="Cyan10605_3133"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3133"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3339"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_4_3"/>
    <dbReference type="OMA" id="PGMAIQA"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="85"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="512" mass="55515" checksum="38C9A5421D49FDAF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z824</accession>
    <name>K9Z824_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220438.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2641"/>
    <dbReference type="EnsemblBacteria" id="AFZ54715">
        <property type="protein sequence ID" value="AFZ54715"/>
        <property type="gene ID" value="Cyan10605_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2641"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2806"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027173_1_0_3"/>
    <dbReference type="OMA" id="YEPNVAS"/>
    <dbReference type="OrthoDB" id="416080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="504" mass="57555" checksum="65DAAB7C80933757" modified="2013-03-06" version="1">MNFKLPSETETRLTLADKFWSDFRLNNQPIKNVVYSSQEIVSNHDFDVVICGGTLGIFLATTLQQKGYKVAIIEKNILQGREQEWNISRSELESLLELDLLTSQELEKIIFTEYNPARIGFYKGYELWVKNILNVGVSPKLLIAKIKEKFISLDGVILENTAFNSAQINDNGVEIKTDKNSLKTRLLIDSMGHFSPIVKQIRNGEKPDGVCLVVGSCGKGFKQNETGDLIYSFTPIINQCQYFWEAFPAKDGRTTYLFTYVDANPERISLKNLMTEYLRLLPEYQQIELDNLDFQRFLFGFFPAYRQSPLKMPWDRIIAVGDSSGMQSPVSFGGFGAMMRHLPRLSLAIDEALKGDYLTREDLALIQPYQPNISVTWLFQKTMSVPIDKQPQPNQINDLMSGVFRVMDKLGDDVLKPFLQDVVQFSGLTKTLPLVNPMLVLPLLPQVGLPILADWLKHYLSLGVYTGLYPFAKGFIGFSEKFSPRQQYYYHRYLELLQYGSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z840</accession>
    <name>K9Z840_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3268"/>
    <dbReference type="EnsemblBacteria" id="AFZ55314">
        <property type="protein sequence ID" value="AFZ55314"/>
        <property type="gene ID" value="Cyan10605_3268"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3268"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_2_3"/>
    <dbReference type="OMA" id="WREPFVD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="18991" checksum="41CED4B53028A0D3" modified="2013-03-06" version="1">MKQNLLGGKSMAIVRFNPLYEINSLHRQMNRLLDEITAWDDTSNSFLKPAVELLDNDNSLMLKVLVPGIDKKDLDVSVTRDSVKVSGEYHRQQENKDTGYYISEFNYGKFERTINLPLPIKNDQVKAEYNDGVLTLILPKLEDEKNKVFKVSLGAEEKPALESESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z857</accession>
    <name>K9Z857_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220291.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2487"/>
    <dbReference type="EnsemblBacteria" id="AFZ54568">
        <property type="protein sequence ID" value="AFZ54568"/>
        <property type="gene ID" value="Cyan10605_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2487"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2636"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_3"/>
    <dbReference type="OMA" id="PLEHWAE"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="36288" checksum="0F6905077EC370F6" modified="2013-03-06" version="1">MRVLVLIPGGISDQILFFPTLQTLKNKYPQATIDVIVEPRSKNSYRICKHVQEVLVFDFQDRNGLADYLNLLGMIRDREYELVITLEQNWIVNFLLWLDGIPTRVGYQSSNSWFLNCTIPKNTDQYIPFMYHDLLKALKIDDPCPDLSVNVPREDIEWAESEQKRLKIKDTGYIIIHGGASILTAYQGINKIYPVPKWQRVIEDIRMKQPDIPIVLLCGPDDLEWTTEIVSLCPYVKVVSPPDIGKLAAIIAGANLMLCTDSAPMQLAIAVGVYTIALFGPTKTTKLLPPKCDRVFGIQSLSSQIADIPTDKILEQIWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z898</accession>
    <name>K9Z898_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl-4,4'-diaponeurosporenoate acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the acylation of glycosyl-4,4'-diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12-methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis; staphyloxanthin biosynthesis; staphyloxanthin from farnesyl diphosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyltransferase CrtO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221139.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3379"/>
    <dbReference type="EnsemblBacteria" id="AFZ55421">
        <property type="protein sequence ID" value="AFZ55421"/>
        <property type="gene ID" value="Cyan10605_3379"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3379"/>
    <dbReference type="eggNOG" id="ENOG503340V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133300_1_0_3"/>
    <dbReference type="OMA" id="FNLPCLW"/>
    <dbReference type="OrthoDB" id="1881045at2"/>
    <dbReference type="UniPathway" id="UPA00029">
        <property type="reaction ID" value="UER00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044021">
        <property type="entry name" value="CrtO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18927">
        <property type="entry name" value="CrtO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="19424" checksum="B3C354F3B8F7FE0A" modified="2013-03-06" version="1">MLLNLNDGRVLLLCVVGWAAWSLLIGFVGYKLPLKHLEIDTWLTQPRPWGETRKWYEQVLRIKDWKDWLPEAGNFFPGGFQKTSIGGGNYALMFRFVAETRRAEYVHIAIWFFWLVTILWTSGWGVVLNLVVGTTFNLPCLWVQRYNRLRLQHLLLLKKTRKITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F8</accession>
    <name>K9Z8F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220731.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2950"/>
    <dbReference type="EnsemblBacteria" id="AFZ55012">
        <property type="protein sequence ID" value="AFZ55012"/>
        <property type="gene ID" value="Cyan10605_2950"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2950"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3139"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_0_3"/>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="254" mass="27135" checksum="A0F79F3858BAC6A5" modified="2013-03-06" version="1">MNKLLDRLLSGLFLMGQIIVHILQGKIYRNNTMEQMAFVGPASLSIALITAVFVGMVFTIQVAREFIYFGATSAVGGVLAIALTRELAPVLTAVVLAGRVGSAFAAEIGTMKVTEQIDALQILKTDPVDYLVTPRVMACCLMLPILTIVSLFMGMMGGLVIADSLYDISNTVFLDSIRNFLKPWDLIASMLKSLVFGIIIAVIGCNWGLTTTGGAKGVGQSTTAAVVISLITIFITNFILSWLMFQGTGSAVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M1</accession>
    <name>K9Z8M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220416.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2618"/>
    <dbReference type="EnsemblBacteria" id="AFZ54693">
        <property type="protein sequence ID" value="AFZ54693"/>
        <property type="gene ID" value="Cyan10605_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2618"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048743_0_0_3"/>
    <dbReference type="OMA" id="PFWDAGY"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="61"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="31837" checksum="FAFB129762D86DF1" modified="2013-03-06" version="1">MSYNPSQSRLEKELEAICIPGHPVWNNWGYQKVQEYIETKLNACGKVEKHIFPSMEMEGCNLILKLEGNNPQLAPILIGAHYDGVPDTAAADDNGTAVVALLQLAEMFAQQSLNRSLWLVAFDQEEWGMRGSSALARHLKEQKQPLKLMISLEMLGFTCEVQNYPQPEMYQLFGSKGDYLALVANQEIYLLVQEMNEIFSRHLPTRFLCVPDRGASFPEITLSDHSPFWECGYDGLLLTDTAFLRNPNYHKYSDTIDSLDLDFFAKVVEGLILVTKHLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X5</accession>
    <name>K9Z8X5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220541.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2749"/>
    <dbReference type="EnsemblBacteria" id="AFZ54818">
        <property type="protein sequence ID" value="AFZ54818"/>
        <property type="gene ID" value="Cyan10605_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2749"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2919"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_0_3"/>
    <dbReference type="OMA" id="DYKGDTV"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26043" checksum="DAFF30DDDE0A7ED6" modified="2013-03-06" version="1">MLFRQLFDQSTWTYTYLIADEDSKEAVLVDPVLEQVDRDFQLIKELGLNLIFCLETHVHADHITGTGKLKELAHCIGIVPEKANVSCADRHILDGEVLKVGKIEIKAIASPGHTDCHFAYLVNGTHLLTGDALFIRGCGRTDFQSGNAEDLYESITEKFFTLPDNTFVYPGHDYRGQTVSTIKEEKQFNPRIAHKDKVEFVEIMNNLNLPNPTKIMEAIPANQQCGNIPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z6</accession>
    <name>K9Z8Z6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase B</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220896.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3126"/>
    <dbReference type="EnsemblBacteria" id="AFZ55177">
        <property type="protein sequence ID" value="AFZ55177"/>
        <property type="gene ID" value="Cyan10605_3126"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3126"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3332"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="MSVIYCL"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016252">
        <property type="entry name" value="Ser/Thr_kinase_SpkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000647">
        <property type="entry name" value="Ser/Thr_PK_SpkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="512" mass="57481" checksum="8DD0440F227B4EAF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z911</accession>
    <name>K9Z911_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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</entry>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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    </evidence>
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    </evidence>
    <sequence length="542" mass="59886" checksum="A987D52259601F36" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
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    <sequence length="314" mass="36005" checksum="B5092C8499AAF0E0" modified="2013-03-06" version="1">MRIFITGGSGCIGHYIADLLIKNTNHELFFLVRNPSKVKFDYNYRSGINIIEDNLTNILAYKDILNTINIAILIATCWGGEVESYQINVEANINLINCLNKKNCERIIYFSTASILDQKNQLLPQAGEIGTDYIKTKYQCFTQLEKHPLYPKIITVYPTLVFGGDEKKPSSHLSAGLKDLPKWFNLIRWFQADGGFHVIHGQDIATIIGYLVENGDKLDPSFERKLVLANSPLTVNQAIKEIGNYLNKKVYLQIPLPIWLANVFIKVFNIQMAKWDYFCLNYRYFTYDKYVNPQSFGLDYYVPNISKLLEISGV</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12328" checksum="FD1C37D84200550A" modified="2013-03-06" version="1">MDLSSISLRGVEIWRIWSPHNIIEQFWKMLKSVLKIAEMKLRKQGIYIGLLIKVIMYLILLSMQFMPSLGRLSLTQIIKKIESTTKLPDVIKEHFQHDFLGVSAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C0</accession>
    <name>K9Z9C0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220707.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2926"/>
    <dbReference type="EnsemblBacteria" id="AFZ54988">
        <property type="protein sequence ID" value="AFZ54988"/>
        <property type="gene ID" value="Cyan10605_2926"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2926"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3113"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_17_1_3"/>
    <dbReference type="OMA" id="CFDDVRW"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016781">
        <property type="entry name" value="Anti-sigma_regulat_PmgA_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020906">
        <property type="entry name" value="Anti_s_fact_PmgA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="16958" checksum="13F24FD6CABE4A3C" modified="2013-03-06" version="1">MISISLPVKFGNWKTVSFASTLYLSPILDLLLCKVPKRLHPEIRLGLQEALVNAAKHGNKLDPSKRVVVKFCCRRGKYFWVVCDQGQGFIQECSCPLDEHSLPPEEAENGRGLCILHQIFDQVLWDSQGTQVTLSKQVPQYSKVSLLMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9F0</accession>
    <name>K9Z9F0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220737.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2956"/>
    <dbReference type="EnsemblBacteria" id="AFZ55018">
        <property type="protein sequence ID" value="AFZ55018"/>
        <property type="gene ID" value="Cyan10605_2956"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2956"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3146"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_3_1_3"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16120" checksum="6F914D64495A3C91" modified="2013-03-06" version="1">MERVAVIGLDIGLRRVGVAGCDGLGLIATELTTVNRRSFKEDVEAFRRIIEEREANLLVAGIPYTMKGEIGFQAKQVIKYAKRLSNALELPLEFVDERLTSLEAEEQLKSSKKYSSRQKGLIDKRAAAIILQQWLDIRRSQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N6</accession>
    <name>K9Z9N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220812.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3036"/>
    <dbReference type="EnsemblBacteria" id="AFZ55093">
        <property type="protein sequence ID" value="AFZ55093"/>
        <property type="gene ID" value="Cyan10605_3036"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3036"/>
    <dbReference type="eggNOG" id="ENOG50333DW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137827_0_0_3"/>
    <dbReference type="OMA" id="LDNWQQL"/>
    <dbReference type="OrthoDB" id="2079377at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12807" checksum="06AE5684D56C559D" modified="2013-03-06" version="1">MQIPNFDLAIIEKSKIIDYLLNINHKRGGSKAKILLNYGYSPENWQQLESDIRKFHLNAEVSIIKETSYGIRYEIISEILTPIHKPLLMKSVWQIDKGTEIPRLITMIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R0</accession>
    <name>K9Z9R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(SSU ribosomal protein S18P)-alanine acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.267</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.267" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220832.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3056"/>
    <dbReference type="EnsemblBacteria" id="AFZ55113">
        <property type="protein sequence ID" value="AFZ55113"/>
        <property type="gene ID" value="Cyan10605_3056"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3056"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3257"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_1_3"/>
    <dbReference type="OMA" id="FEPIGFR"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="157" mass="17955" checksum="9582E26AFD21F7D5" modified="2013-03-06" version="1">MSLAEIQFQVLTDKDLEQVLELDRICFGGLWSLDSYKREIESPNSYLLIITVNTHSGTKVIGFGCFWAILEEAHITILAIHPDFQGQGLGSLLLENLLKEAVNRKLERATLEVGENNTKAINLYQKFGFKEAGRRKKYYKKTGEDALIFWKSIRENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S5</accession>
    <name>K9Z9S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221053.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3289"/>
    <dbReference type="EnsemblBacteria" id="AFZ55335">
        <property type="protein sequence ID" value="AFZ55335"/>
        <property type="gene ID" value="Cyan10605_3289"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3289"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3504"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107996_0_0_3"/>
    <dbReference type="OMA" id="YICPGAN"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27028" checksum="FA28AAA7F39741EE" modified="2013-03-06" version="1">MDSDLNFTEKVNQEKTKVPTRAKYPKLILENLFAFAPNRDTLGGTSYLLIHPLGNILVDCPFWSEENKNFCLSHGVKYLFVTNRDGISKHISHIKKELHCELVIQEQEAYLLPNLSPITFSEEYRLYDDCFGLWTCGYSPASACLYYGNYGGVLFSGRHLLPVGNDKISALKLKKTFHWLRQLRSVQKLCDRFSEKTLEYICPGANTGYLRGQGFMNKGYQKLIESNQNYVASDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W0</accession>
    <name>K9Z9W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)-dependent nickel-iron dehydrogenase diaphorase component subunit HoxU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221225.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3471"/>
    <dbReference type="EnsemblBacteria" id="AFZ55507">
        <property type="protein sequence ID" value="AFZ55507"/>
        <property type="gene ID" value="Cyan10605_3471"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3471"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3696"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_3_3"/>
    <dbReference type="OMA" id="NHVCAVC"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016214">
        <property type="entry name" value="NAD-red_Hydgase_HoxS_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000309">
        <property type="entry name" value="NAD_red_hyd_HoxU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="238" mass="26134" checksum="82A049A21913E439" modified="2013-03-06" version="1">MAVVTLKIDDIDVAIASGSSILTASKEAGVKIPTLCHLEGVSDVGACRLCLVQIKGSDKLVPSCITEVREGMEVFTQTDILKEYRKMTVELLFAEGNHICATCVANNNCQLQDTAVEVGMDHSRFNYRFPDRDVDLSHPMFGIDHNRCILCTRCVRVCSEIEGAHVWNVGFRGAAAKIISGLNQPWGDVSACTSCGKCVEACPTGTIFHKGVTTAEMHKHPDNIDFLHTAREKHQWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA29</accession>
    <name>K9ZA29_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221168.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3408"/>
    <dbReference type="EnsemblBacteria" id="AFZ55450">
        <property type="protein sequence ID" value="AFZ55450"/>
        <property type="gene ID" value="Cyan10605_3408"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3408"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3631"/>
    <dbReference type="eggNOG" id="COG0371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044754_0_0_3"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008888">
        <property type="term" value="F:glycerol dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fe-ADH" evidence="6">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="371" mass="39704" checksum="E6C3B01AC07DACC3" modified="2013-03-06" version="1">MSKSKSISIEVGQIFSLQVAPGNIIKGENSLSNSGDAIASFGQMPLVVGGEKTIKLIETYLEPICKKFNLKPRYASYLPDCSETSLKRLEKAVKTHEADFIIGVGGGKSLDSAKLLAHNCHLPVITIPTSGATCAAWTALSNIYSESGAFQYDVSLRHCPNLLILDYNIIASAPKYTLIAGIGDAIAKWYEASVSSGNSTATLTIAAVQQARVLRDILLQKAETALQNPLSETWKEVVDATVLLAGVSGGLGGANCRTVAAHAVHNGLTHLEATHGKLHGAKVAYGILVQLRLEETIANNQLAKTARQQLIKFYQSIGLPITLEDLGLTNITLNQLRQCAEITCKPESDIHRLPFNVTPDILLSAMVSTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA45</accession>
    <name>K9ZA45_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photosystem II reaction center protein K</fullName>
            <shortName evidence="9">PSII-K</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psbK</name>
        <name evidence="11" type="ordered locus">Cyan10605_3177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PsbK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220946.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3177"/>
    <dbReference type="EnsemblBacteria" id="AFZ55228">
        <property type="protein sequence ID" value="AFZ55228"/>
        <property type="gene ID" value="Cyan10605_3177"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3177"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3386"/>
    <dbReference type="eggNOG" id="ENOG5032YQR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174355_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00441">
        <property type="entry name" value="PSII_PsbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003687">
        <property type="entry name" value="PSII_PsbK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037270">
        <property type="entry name" value="PSII_PsbK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35325">
        <property type="entry name" value="PTHR35325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02533">
        <property type="entry name" value="PsbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161037">
        <property type="entry name" value="SSF161037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="2 9" id="KW-0674">Reaction center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="propeptide" id="PRO_5005069559" evidence="9">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023249487" description="Photosystem II reaction center protein K" evidence="9">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="45" mass="5122" checksum="4F2F51CF198C3D07" modified="2013-03-06" version="1">MEATMLLAKLPEAYEIFKPLVDVLPVIPLFFLLLAFVWQAAVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA55</accession>
    <name>K9ZA55_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ordered locus">Cyan10605_3435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221193.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3435"/>
    <dbReference type="EnsemblBacteria" id="AFZ55475">
        <property type="protein sequence ID" value="AFZ55475"/>
        <property type="gene ID" value="Cyan10605_3435"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3435"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3660"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_0_1_3"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="29702" checksum="1CA48B8CD793FCAF" modified="2013-03-06" version="1">MNQENLIPVVVNGAAGKMGKEVIKAVKNAPDMMLVGAIDRNQAVIGKDVGEVAGCGALEVPIVDDLESVLVLATQHKIQGVMVDFTHPDCIYDNIRSAIAYGIRPVVGTTGLSPEQIKDLAEFAEKASTGVLIIPNFSIGIVLMQQAAIQAAQYFDHVEIIELHHNQKADAPSGTAIKTAEMLSDLGKTYNPQLVEETENLKGARGSICGDNIRIHSVRLPGLIAHQEIIFGAQGQIYTLRHDTSDRSCYMPGVLLSIRKIVELKTLVYGLEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA74</accession>
    <name>K9ZA74_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220981.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3216"/>
    <dbReference type="EnsemblBacteria" id="AFZ55263">
        <property type="protein sequence ID" value="AFZ55263"/>
        <property type="gene ID" value="Cyan10605_3216"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3216"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3428"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_3"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="30214" checksum="645EFE1C45811977" modified="2013-03-06" version="1">MNKSKVNILNGFWRLSEDIPKPLYITLTISSIALPLFLWWFITTVGNIDPKFLPSPANVLQAFGRLWSSGELMQDTIASLWRVGVGFFLAALFAIPIGILMGSFASIRALLEPLFGLMRYMPAPAFIPLLILYLGIGEEPKITLIFIGVFFFNALMVMDTVKFVSKDLIESTYILGGNKWQILTQVILPHSLPGILDACRINLAAAWQLVIVSELIASTEGLGRRISVAGRFLKTDEIFVGLIVIGIIGLSLDLFFQYLLRISCKWSSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAM7</accession>
    <name>K9ZAM7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ordered locus">Cyan10605_3406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221166.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3406"/>
    <dbReference type="EnsemblBacteria" id="AFZ55448">
        <property type="protein sequence ID" value="AFZ55448"/>
        <property type="gene ID" value="Cyan10605_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3406"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3628"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_2_0_3"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="10838" checksum="CE2C9FC4C2BEE821" modified="2013-03-06" version="1">MSLSQAEVKKVANLARLHLTEAEEEAFAPQLSAILDYFEQLKELDTENVEPTTRAIDVNNITREDVQSTYEDRESLLNVAPERDDDFFQVPKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAY0</accession>
    <name>K9ZAY0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein, Crm2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221260.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3510"/>
    <dbReference type="EnsemblBacteria" id="AFZ55543">
        <property type="protein sequence ID" value="AFZ55543"/>
        <property type="gene ID" value="Cyan10605_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3510"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011213_0_0_3"/>
    <dbReference type="OMA" id="WLWDIRQ"/>
    <dbReference type="OrthoDB" id="1599626at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3692" evidence="2">
        <location>
            <begin position="218"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1025" mass="118299" checksum="B5741E800F96CE39" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ54</accession>
    <name>K9YZ54_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217943.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0050"/>
    <dbReference type="EnsemblBacteria" id="AFZ52211">
        <property type="protein sequence ID" value="AFZ52211"/>
        <property type="gene ID" value="Cyan10605_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0050"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.52"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_3"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="22224" checksum="919533576D9586F9" modified="2013-03-06" version="1">MLKIGQKAPEFTATAVIDQEFKVVKLSDYLGKYVVLFFYPLDFTFVCPTEIIAFSERYEEFSSLNTEILGVSVDSEFAHLAWIQTERKQGGIGDINYPLISDLSKEISKAYEVLDESAGVAARGLFIIDTEGNIQQITINNLSCGRSVDETLRNLKAIQHVHSHDNEVCPVDWQEGDKTMIPDPLKSKLYFESNSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ91</accession>
    <name>K9YZ91_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52219">
        <property type="protein sequence ID" value="AFZ52219"/>
        <property type="gene ID" value="Cyan10605_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0058"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.60"/>
    <dbReference type="eggNOG" id="ENOG503367W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166096_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11818" checksum="58F4D6934917238E" modified="2013-03-06" version="1">MFSKNNPDKNPMATSEIENLTNENNEDLFDTELEEIDSPPLVKLVEKISGILSPYFIVIVGLYLYDNNFLFGSILILIGVLSLLKISYEDVLAWIEKIKGMFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZD1</accession>
    <name>K9YZD1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218033.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0144"/>
    <dbReference type="EnsemblBacteria" id="AFZ52301">
        <property type="protein sequence ID" value="AFZ52301"/>
        <property type="gene ID" value="Cyan10605_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0144"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_3"/>
    <dbReference type="OMA" id="IWIMSDT"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="24856" checksum="2484619FCED936D6" modified="2013-03-06" version="1">MENKINLDNIEAIIFDLGGVIIGVEMESPYQTLLKISPRNEQELLSELKQIAYEYEIGKIEDITFLSAIKKKAQIDLDLVEIENIWNQMLNYVPEYMGELLAKIKQEKRTFILSNTNPIHIREVKKRFAQSVKEYTFESLFEKIYYSHEISLHKPDQAIYDYVVKTSKLNPLRTLFIDDNYHNVIEAKKYGLQAIHMNPVMNLDKIFPFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZH6</accession>
    <name>K9YZH6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ordered locus">Cyan10605_0195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218083.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0195"/>
    <dbReference type="EnsemblBacteria" id="AFZ52351">
        <property type="protein sequence ID" value="AFZ52351"/>
        <property type="gene ID" value="Cyan10605_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0195"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.205"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_2_0_3"/>
    <dbReference type="OMA" id="LVVWPNK"/>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="8774" checksum="A199D36EA1E5E46D" modified="2013-03-06" version="1">MTNKDTVKTKNANSNEAQGKEIISSGFVEETKQELAKVVWPSRQQLLSESVAVILMVTVVATLIYLMDKLFGWLAGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZH8</accession>
    <name>K9YZH8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218051.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0162"/>
    <dbReference type="EnsemblBacteria" id="AFZ52319">
        <property type="protein sequence ID" value="AFZ52319"/>
        <property type="gene ID" value="Cyan10605_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0162"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.168"/>
    <dbReference type="eggNOG" id="COG2948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069770_0_0_3"/>
    <dbReference type="OMA" id="VRHEDAK"/>
    <dbReference type="OrthoDB" id="1692147at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042217">
        <property type="entry name" value="T4SS_VirB10/TrbI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938552" evidence="1">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="234" mass="25021" checksum="590DC5E7BDE10A01" modified="2013-03-06" version="1" precursor="true">MFKPISLTSKTLRFMVLSLSLTTLVGSFASVEARPDKYYRSAPPGWERKNEVNQNRKNPTYYSANLNSGTVIPTTLPSAKKILVTKDETLPVTLVVTRDVKDNSGRVVIPRGSEVVGEVRPAGSGSRFVGNTVILPNGEQYSIQANSKIVTRTEKISDGRNTDAIWQGALAGSAAATLISAVTGDKAIATEEVLGGAGFGALAGFLFGGTRDRELISINTQEDLDLTVTSNISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZN5</accession>
    <name>K9YZN5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Photosystem I reaction center subunit III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">PSI-F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 28-168</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria). This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PsaF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
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        <source>
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    <sequence length="168" mass="18688" checksum="54D6752FDD6BE6B9" modified="2013-03-06" version="1" precursor="true">MRKIFSLVLAFTLSITLWFNFAPAAQADLSHLTPCSESPAYQAKAKSFRNTTSNPESGQKRAESYAEALCGPEGYPHLVVDGRLDHAGDFIIPGLLFLYVAGWIGWVGRSYLIAIREEKDTEMKEIIIDVPLAINKMLFGFMWPLQAFGEFTSGKLTVKDSEIPVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ52424">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFZ52424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="DCA7A884C05AD960" modified="2013-03-06" version="1">MAQLTPQSPLYNFPLPEIEAWLKKMGCDQNPQELNCWYVKKGNWEAEITLDIEDICVSYLNAGADGSDIKRAFPYSLSRQDIEDAVFSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0432"/>
    <dbReference type="EnsemblBacteria" id="AFZ52576">
        <property type="protein sequence ID" value="AFZ52576"/>
        <property type="gene ID" value="Cyan10605_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0432"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.455"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cellulose_synth"/>
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        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
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        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="699" mass="80784" checksum="0E6E25843E8CA74D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0C3</accession>
    <name>K9Z0C3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ordered locus">Cyan10605_0504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218377.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0504"/>
    <dbReference type="EnsemblBacteria" id="AFZ52646">
        <property type="protein sequence ID" value="AFZ52646"/>
        <property type="gene ID" value="Cyan10605_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0504"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.534"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="37" mass="4366" checksum="DA9366816BFEF55F" modified="2013-03-06" version="1">MKVRASVKKICDKCRVIRRRGRVMVICSNPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0G2</accession>
    <name>K9Z0G2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217929.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52197">
        <property type="protein sequence ID" value="AFZ52197"/>
        <property type="gene ID" value="Cyan10605_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0036"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.38"/>
    <dbReference type="HOGENOM" id="CLU_195269_2_0_3"/>
    <dbReference type="OMA" id="RYSNSEQ"/>
    <dbReference type="OrthoDB" id="2089721at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="60" mass="7217" checksum="3976E068D8436FDF" modified="2013-03-06" version="1">MSKRRNPKKEKAERNKAYARQFRKKFSRYSSRNNKGFNRNNSKSDDNDTTETRSDSQNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0H2</accession>
    <name>K9Z0H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218407.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0534"/>
    <dbReference type="EnsemblBacteria" id="AFZ52676">
        <property type="protein sequence ID" value="AFZ52676"/>
        <property type="gene ID" value="Cyan10605_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0534"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.565"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_7_1_3"/>
    <dbReference type="OMA" id="AYGLFFY"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="173"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="37921" checksum="2B38526A6F64CDB2" modified="2013-03-06" version="1" precursor="true">MDLKFKSHWLFFQPVILISPFFFWGTAMVAMKSVIPQTTPLFMAGVRIFPAGLLILLVALMLGKSQAISLRGWLWICFFALVDGCCFQGFIGEGLMRTGAGLGSVMIDSQPLAVAIMSRWLFKEVIGFWGWLGLLTGIVGISLIGLPDEWILRGLQGDFTGFNWSWNGLFDNGEWLMLLASLSMAGGTIMIPFVCRHVDAVVATGWHLVIGGLVLFLFSFQYETNQWINLDLNSWLLLSYATIFGSAIAYGVFFFLASKGNLTSLSALTFLTPVFALTFGNLLLEEKLSDLQWQGVWLTLVSIYLINQREKISKFMFRENLYFFLKKLKQTQTTNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I3</accession>
    <name>K9Z0I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217959.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0066"/>
    <dbReference type="EnsemblBacteria" id="AFZ52227">
        <property type="protein sequence ID" value="AFZ52227"/>
        <property type="gene ID" value="Cyan10605_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0066"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.68"/>
    <dbReference type="eggNOG" id="ENOG5032SVX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141457_1_0_3"/>
    <dbReference type="OMA" id="DIIRHNV"/>
    <dbReference type="OrthoDB" id="1812225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12200" checksum="44EF736C24A1BD71" modified="2013-03-06" version="1">MVFDSNFFQRESETTLKNTLVEYLQKQHPETLERVAQSATPEVREIITHNVQGLLGVLPSDGFNVQIVTDRQYLANLLASAMMTGYFLCQMEKRKDLEDSISNTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J6</accession>
    <name>K9Z0J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0083"/>
    <dbReference type="EnsemblBacteria" id="AFZ52242">
        <property type="protein sequence ID" value="AFZ52242"/>
        <property type="gene ID" value="Cyan10605_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0083"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071497_0_0_3"/>
    <dbReference type="OMA" id="THTWAND"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="38055" checksum="2C823B0833C3CE56" modified="2013-03-06" version="1">MKKSTLYRLILHNCKDKSSLEKGFSLIEAISTLLMGSIILGVALSGFFQIKEFFGKDKLTTDVNQRLRTAFQTIGPDLQQMGENVSNIEFPAVALSTNNGTSEITIRRGGLEPLTLCADISANSTDSVTVLDKNFTASPACISVNDDDGDGWPDTVKEWQNFRNGNTIRAYIVDTSTNKGEFFEYKGEETLDSGGATMTPSGGTEPYVVNLTTNTHTWANDYSASTTAIYLFDESTYKVTNNTLQLIRNGEVFDLVEDIEKLDITAIIQENPTATEYECKTINLTEVDCDPTFSIDDYTWNLIKSLDVEVTALPPQDKGNFAKLTEDDLTLSQQFLPRNRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P6</accession>
    <name>K9Z0P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218492.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0622"/>
    <dbReference type="EnsemblBacteria" id="AFZ52761">
        <property type="protein sequence ID" value="AFZ52761"/>
        <property type="gene ID" value="Cyan10605_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0622"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.656"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599989_0_0_3"/>
    <dbReference type="OMA" id="VICAPEY"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="18428" checksum="A22970D92C3AC350" modified="2013-03-06" version="1">MKISIIVASNNKNLELAHQLNKIAIEMGQQTQIIDLIEEDLPLYTPKIQAQSGIPDKVQSLSQTLINTEGMIFVAPEYNGGIPPILTNAIAWLSVSGDDWRRCFNSKPAMIATHSGGGGQYVLLAMRSQLSYIGMNVVGRQIITNYQKSLNLDSAREVISQLVAMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W3</accession>
    <name>K9Z0W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217922.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0029"/>
    <dbReference type="EnsemblBacteria" id="AFZ52190">
        <property type="protein sequence ID" value="AFZ52190"/>
        <property type="gene ID" value="Cyan10605_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0029"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.31"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_3"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="465" mass="51609" checksum="79B4F102AA91EECE" modified="2013-03-06" version="1">MSDNFKATENNSRHELRDLVRSQLQILLDQNNLKGAKSLLIPVQPVDIAEAIASLSESAQAIAFRLLDKNKAIEVYEHLEAKIQGILIEDFKRQEVIDIVDKMSPDDRARLFDELPATIVSRIITQLSDQERQATNLLLGYQENTAGRIMTPEYIFVKETFNINETFAKIRSLANTSELIYYVYVVNETRQLTGVVSFRDLVIHGRQTIVKDIMTQDIIYVKTDTDQEEVANLIKRYDFFALPVVDRELRIVGVVTVDDVIDILQKKATEDIYALSAIQGEGENYFKTNLFTITKRRVGWLLVLLLTNTVTGGIIGAQEDIIAQYTILAAFMPLLADTGGNIGAQSSTVVIRGISTEEVRELGTTKVIIREGLAGLLLGFVLGLVTMIWAYLLPSNDNNLIVAFAVGITLTAICTLASIAGSALPFLFRRLGLDPALMSGPFITTAVDVLGILIYFNIARAMLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z110</accession>
    <name>K9Z110_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217972.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0081"/>
    <dbReference type="EnsemblBacteria" id="AFZ52240">
        <property type="protein sequence ID" value="AFZ52240"/>
        <property type="gene ID" value="Cyan10605_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0081"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123096_0_0_3"/>
    <dbReference type="OMA" id="VELINNW"/>
    <dbReference type="OrthoDB" id="1833410at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="262" mass="28388" checksum="51EAF1C8B8340337" modified="2013-03-06" version="1">MEKQGKKTKFLNNFIQSLKTSKNYGYTLVEVLTVLIILGIMGALMGPRLFFGDSSSASGDAYNLAKSLVGVTRQRAISQTSAARLSFDPNQSDKFLIEIANTRGCEALTRLSEAAVSSQTDIKVYSTTGFQIGDKLKIGSDTTSNEITGKDNTTITLGVALGTSQNKDSTVELVENWKEDSALNLKKNIGNGKYIYEYLQLPENVTVTSNITNWTLCFNSRGIATIYDNSGNSQAKLELTFKDGSSNEETLTILKGGAIATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z143</accession>
    <name>K9Z143_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6398 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218012.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52280">
        <property type="protein sequence ID" value="AFZ52280"/>
        <property type="gene ID" value="Cyan10605_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0122"/>
    <dbReference type="eggNOG" id="ENOG502Z8XI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071278_0_0_3"/>
    <dbReference type="OMA" id="WIATLIE"/>
    <dbReference type="OrthoDB" id="580355at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045651">
        <property type="entry name" value="DUF6398"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19935">
        <property type="entry name" value="DUF6398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6398" evidence="1">
        <location>
            <begin position="203"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="334" mass="38382" checksum="794F9865E4A36085" modified="2013-03-06" version="1">MTFQLNKLDNLDFDEGQEIIEDYIEDAIWDFVDSPVGQEYIKTREQGGFWIHHFIEFGYMYEGYTLSTMTVSDVKTIMEYILPRKLMILNEEEVEDAIPELIAFWQYLGETHKRKTAKGIIKYLKTLENKFTAMMTDDSSGSFVKSMLMNAHKSGLDMTSEEALIKFLQGQSQNKVSSDKNLQVSQLLGKSTIPPSMKNKYDEITNLTDDFCRNYLNDEYLEFSRKLTTVLCNYQPSPLNKGKAKSWACGIIHALGMINFLADSSFEPYMKSSELYQRFGVSESTGCGKSKQIRDLLEMSRLDQEWMMPSVSESHPMSAIANIASTLKQILDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z159</accession>
    <name>K9Z159_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ordered locus">Cyan10605_0766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cellular thylakoid membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218630.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0766"/>
    <dbReference type="EnsemblBacteria" id="AFZ52899">
        <property type="protein sequence ID" value="AFZ52899"/>
        <property type="gene ID" value="Cyan10605_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0766"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.806"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_3"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="150"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="372"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="503" mass="54007" checksum="675333AAC52C92FF" modified="2013-03-06" version="1">MVAIRPDEISSIIRQQIESYDQQVQVSNVGTVLQVGDGTARIYGLDQAMAGELLEFEDGTVGIALNLEQDNVGAVLMGDGLDIQEGSSVKATGKIAQIPVGDALVGRVLDALARPLDGKGDIETSETRLIESPAPGIVARKSVCEPMQTGITAIDAMIPVGRGQRELIIGDRQTGKTAIAVDTIINQKSEDVICVYVAIGQKASTVANVVDTLREKGALDYTIVVAANANDPATLQYLAPYTGAAIAEYFMYKGKATLVIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDELGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSSDLFNAGFRPAINAGISVSRVGSAAQTKAMKQVAGKLKLELAQFAELEAFSQFASDLDAATQAQLARGQRLRQLLKQPQNSPLAVWEQVAQVYTGINGLLDDIAVEQIQDFVTSLRNYIKNSKPKFIEIVSTEKKLTEEAEALLKEAVAEAKQAFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z163</accession>
    <name>K9Z163_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0324"/>
    <dbReference type="EnsemblBacteria" id="AFZ52472">
        <property type="protein sequence ID" value="AFZ52472"/>
        <property type="gene ID" value="Cyan10605_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0324"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_2_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="11478" checksum="2337E07681050479" modified="2013-03-06" version="1">MSRELRMFKFEYDSHKSQSNAKKHGMDFVEAQQLWQDEDLLEIPTKTETEPKWIVIAKLKQKHWTAVITYRGDIVPIISVRRAKSKEIKLYESERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I7</accession>
    <name>K9Z1I7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="4" type="synonym">rps14</name>
        <name evidence="5" type="ordered locus">Cyan10605_0042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0042"/>
    <dbReference type="EnsemblBacteria" id="AFZ52203">
        <property type="protein sequence ID" value="AFZ52203"/>
        <property type="gene ID" value="Cyan10605_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0042"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.44"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_3"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="11319" checksum="CFD6EDD663A86684" modified="2013-03-06" version="1">MIAREVKRAKLVAKYAHKRAELKEQIRTAEDPAERFELQRQLQRLPLNSSPYRQRNRCWVTGRPRGYYRDFGLSRNVLREWAHQGLLPGVVKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J7</accession>
    <name>K9Z1J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218770.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0909"/>
    <dbReference type="EnsemblBacteria" id="AFZ53039">
        <property type="protein sequence ID" value="AFZ53039"/>
        <property type="gene ID" value="Cyan10605_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0909"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.955"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_3_3"/>
    <dbReference type="OMA" id="FSPFGNK"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="372"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="678" mass="75785" checksum="D53B04D254606A74" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L7</accession>
    <name>K9Z1L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218832.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0971"/>
    <dbReference type="EnsemblBacteria" id="AFZ53101">
        <property type="protein sequence ID" value="AFZ53101"/>
        <property type="gene ID" value="Cyan10605_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0971"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_3"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="21560" checksum="B54643A57B3FB125" modified="2013-03-06" version="1">MILVIDNYDSFTYNLVQYLGELATDYKVAQDIRVVRNDQISLTEISALKPDAIVISPGPGTPDSAGICLELVEKLGQEYPILGVCLGHQTIGQVFGGKVISAPVLMHGKTSEIKHSNIGVFQDLPNPLTATRYHSLIVEKETIPPILEITAWTEDGIVMGIRHQEFKHIQGVQFHPESILTDSGLKLLGNFLKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P2</accession>
    <name>K9Z1P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218005.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0114"/>
    <dbReference type="EnsemblBacteria" id="AFZ52273">
        <property type="protein sequence ID" value="AFZ52273"/>
        <property type="gene ID" value="Cyan10605_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0114"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.117"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_3"/>
    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28113" checksum="13A3D9D2FF1F20B0" modified="2013-03-06" version="1">MNNKFVNQEKKITAVILAGGFGTRVKHLLPDIPKPMAKVLDKPFLEWIIRYLHQQNINNFLLSTGYLSTIIKNYFNTSLFDNLSIKCYEELEPLGTGGGFINAVKQDKSYTDYWLVANGDSLIFSNLKPFFECLNDDTVEGVILGLTVEDASRYGSLKFDDDYNLISFAEKKDGKGIINGGIYLFKNDVLAKFPQNNKLSFEYDIFPYLLSQGCKIKVHITSAPFLDIGTPETLIQAEKFIAENWQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P9</accession>
    <name>K9Z1P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218015.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0126"/>
    <dbReference type="EnsemblBacteria" id="AFZ52283">
        <property type="protein sequence ID" value="AFZ52283"/>
        <property type="gene ID" value="Cyan10605_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0126"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.128"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_3"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="42861" checksum="1196784D7457DC9C" modified="2013-03-06" version="1">MTKPSCEYQPGLEGIPVAQSSISFVDGKNGILEYRGINIEELAQKSTFLETAYLLIWGKLPTKDELANFQDEITRHRRVKYHIRDMMKCFPESGHPMDALQTSAAALGLFYSRRALAKEEYIRDAVVRLLAKIPTMVAAFAQMRMGNDPVQPSDNLNYAANFLYMLTEKEPEPLEARIFDVCLMLHAEHTMNASTFSAMVTASTLTDPYAVVASAVGTLAGPLHGGANEEVLVMLEEIGSVENVRPYIEDCIENKKKIMGFGHRVYKVKDPRAKILQQLAERLFELTGHDEYYDIALEVEKVVTEKLGHKGIYANVDFYSGLVYRKLGIKPDLFTPMFAISRVAGWLAHWKEQLAVNRIFRPTQVYIGDRGIPYVAIEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T1</accession>
    <name>K9Z1T1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neutral amino acid ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218892.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1035"/>
    <dbReference type="EnsemblBacteria" id="AFZ53161">
        <property type="protein sequence ID" value="AFZ53161"/>
        <property type="gene ID" value="Cyan10605_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1035"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1097"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_0_3"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="41036" checksum="30E2BCB667399C1A" modified="2013-03-06" version="1" precursor="true">MVEYLVFLTISASLYSLFALGLNLQWGFTGLINFGHVAFMTIGAYTTVLLESQGVPLFLAVIIGALGASIFGLIIGFSSIKLREDYLAIVTIGAGELVRLIVQNEEWLTKGTFGIQGYNLPFGTFKPNPLGKLLMVAILTVLAVFVVWRLWINVRQRLNLAKNIQGKSYQPPSLLSTYVWGSLAFIFILICYINGAIALMDYTYKAGLMLLILITLAVIYYGLDIIIHSPWGRVLKAIREDEEVAKALGKNVFWYKLQAFMLGGAIAGLAGAFYSWQLTTIYPSSFEPLMTFNAWIIVVLGGSGNNAGVILGAMIFWGYDSLTRFIFSSMPFITASQVGAFRVMVIGLILMILMIWRPQGILGRKGELSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T6</accession>
    <name>K9Z1T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218897.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53166">
        <property type="protein sequence ID" value="AFZ53166"/>
        <property type="gene ID" value="Cyan10605_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1040"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13259" checksum="6AD3E8C0B62FE1E2" modified="2013-03-06" version="1">MSKEAVEQFFARIPEDNELQQKLVSILQEDIDHRQETAKLAQEYGFDVTAEELSEEAKQRQEEFAQNPESEELSEEELESVAGGSIPSITVGIFQPLTINTYNMPGSISNPFPKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U0</accession>
    <name>K9Z1U0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arogenate dehydrogenase (NADP)</fullName>
            <ecNumber evidence="3">1.3.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.78" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218070.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0182"/>
    <dbReference type="EnsemblBacteria" id="AFZ52338">
        <property type="protein sequence ID" value="AFZ52338"/>
        <property type="gene ID" value="Cyan10605_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0182"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.189"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_2_0_3"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033730">
        <property type="term" value="F:arogenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="30241" checksum="985516AFA5F2276C" modified="2013-03-06" version="1">MKIGIIGLGLIGGSLGLDLTAKGYEVIGVSRKKETCDRALEKQIVTTAGQNLELLSKTDLIFVCTPIEAILRTIESIIPHLSPETIITDVGSVKGAIASPATKLWSNFVPSHPMAGTANQGVEAAEYNLFNNAPCVITPLPQTSPLAITKVSHIWETVGCRLYQSTPELHDRAVAWISHLPVMISANLIYSCTHTSSPEVIKLAQALASSGFKDTSRVGGGNPELGLMMAQYNRQQLINSLREYQQNLDLLIESIEGENWEALTNILQETHQNRPNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z8</accession>
    <name>K9Z1Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218937.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1083"/>
    <dbReference type="EnsemblBacteria" id="AFZ53206">
        <property type="protein sequence ID" value="AFZ53206"/>
        <property type="gene ID" value="Cyan10605_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1083"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1146"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094945_1_0_3"/>
    <dbReference type="OMA" id="CVERNPW"/>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="30380" checksum="9166D149CF5D92F5" modified="2013-03-06" version="1">MIISHKHKFIFIHCRKVAGSSISAFLSNKLGRFDLQIGAWGDSFDLGVLPNLRCFLDLLYPLSTVKMIERIMVEPSTLFQKKKLILAINAAQKEKYKKSLGNNPPHPTASCIKHYNPEAWKKYYKFCFVRNPYERVVSDYLWRTKTKNVHNVSFLEYLRILDDDSNHHKVKPVNYDNWSMYTINNTVVVDFIGRYENLTDDMAKVCSVLNIPFSPNMFPQAKKNNHRYDYRKWYKSEECALVEKIFAEEINYFNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z240</accession>
    <name>K9Z240_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="5" type="synonym">rpl5</name>
        <name evidence="9" type="ordered locus">Cyan10605_0513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218386.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0513"/>
    <dbReference type="EnsemblBacteria" id="AFZ52655">
        <property type="protein sequence ID" value="AFZ52655"/>
        <property type="gene ID" value="Cyan10605_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0513"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.543"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_3"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="20215" checksum="8D8EF268A8211A53" modified="2013-03-06" version="1">MSKLKTYYQETIVPKLKEQFGYTNIHQVPKVTKVVINRGLGEASQNAKALESSLSELAVITGQKPVVTRAKKAIAGFKIRQGMPVGAMVTLRSDKMYAFLERLINLSLPRIRDFRGISPKSFDGRGNYSLGVKEQLIFPEIEYDSIDQIRGFDISIITTANTDEEGRALLKEMGMPFRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z249</accession>
    <name>K9Z249_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218935.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1081"/>
    <dbReference type="EnsemblBacteria" id="AFZ53204">
        <property type="protein sequence ID" value="AFZ53204"/>
        <property type="gene ID" value="Cyan10605_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1081"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105702_0_0_3"/>
    <dbReference type="OMA" id="DWHERLT"/>
    <dbReference type="OrthoDB" id="1241673at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="29305" checksum="675256C7B5265926" modified="2013-03-06" version="1">MQKRRIDSSIFLAIFNDLNIEISSQSRILDFGCGNGNTVKELLDLGYNAKGCDFKFKDGEHVAFLSKQGYIKLISDNPYKLPYPDNTFDILISNQVMEHVKNYGETLAEIYRVLKPNGVCCHIFPSKYKIIESHVYVPFSSIIRNQYYLLLWAFLGIRKSTQKGKKPQEIARENQAYLLSNTNYLSISQVIKEFNSLFKNIYFVEKYYLKNSPSQRGRILYKWGEKIPLIFLLYRFFMSYIIIASDEKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z254</accession>
    <name>K9Z254_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Capsular exopolysaccharide family</fullName>
            <ecNumber evidence="18">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Cyan10605_1086</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="18"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218940.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1086"/>
    <dbReference type="EnsemblBacteria" id="AFZ53209">
        <property type="protein sequence ID" value="AFZ53209"/>
        <property type="gene ID" value="Cyan10605_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1086"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1150"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_2_2_3"/>
    <dbReference type="OMA" id="HTNGLMM"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Wzz" evidence="16">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="17">
        <location>
            <begin position="577"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="758" mass="85052" checksum="C1E0B4E348FBD6F8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A6</accession>
    <name>K9Z2A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219065.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1217"/>
    <dbReference type="EnsemblBacteria" id="AFZ53336">
        <property type="protein sequence ID" value="AFZ53336"/>
        <property type="gene ID" value="Cyan10605_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1217"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1284"/>
    <dbReference type="eggNOG" id="ENOG5032F4U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134228_0_0_3"/>
    <dbReference type="OMA" id="SWDFSIY"/>
    <dbReference type="OrthoDB" id="1694502at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002636">
        <property type="entry name" value="DUF29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34235">
        <property type="entry name" value="PTHR34235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01724">
        <property type="entry name" value="DUF29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="16305" checksum="3C26A9EDD003C0AA" modified="2013-03-06" version="1">MEELLALRQYIEEKNYDRALELVAELEEMSKEDKLNKIFSYAVILLLHLIKQQAEKRTTRSWDFSIYNSIKEIKKINKRRKSGGYYATEEELKEILADAFDTAIRKASLEAFEGKYNPEELMLKIDYDSIQSSALKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D5</accession>
    <name>K9Z2D5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218279.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0404"/>
    <dbReference type="EnsemblBacteria" id="AFZ52548">
        <property type="protein sequence ID" value="AFZ52548"/>
        <property type="gene ID" value="Cyan10605_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0404"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.427"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_3"/>
    <dbReference type="OMA" id="HEGAITK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="11941" checksum="D33C2546DBE353B4" modified="2013-03-06" version="1">MSKVIEIEDSQFKSAVIEENQPVLAYFWAQWCGPCRLVSPSISWIAETYSDRLKVVKLEVDASPESVSQCKVEGVPALRLFKQGEVVKSHEGAIGKDKLKEFVEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M3</accession>
    <name>K9Z2M3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ordered locus">Cyan10605_1284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219128.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1284"/>
    <dbReference type="EnsemblBacteria" id="AFZ53399">
        <property type="protein sequence ID" value="AFZ53399"/>
        <property type="gene ID" value="Cyan10605_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1284"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1356"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_3"/>
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    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="purM"/>
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    </dbReference>
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    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="336"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ53399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="36465" checksum="09EB9318E23B272B" modified="2013-03-06" version="1">MDYKQAGVDVEAGREFVKKISENVASTYRREVLGGLGGFGGCFEIPAGYQQPVLISGTDGVGTKLKIAHQLNRHDTVGIDLVAMCVNDILTSGAEPLFFLDYLATGKLNGNQLAEVINGIVIGCKESGCALLGGETAEMPGFYQQGEYDIAGFCVGIVEKSRIIDGSAIQAGNVAIALSSSGIHSNGFSLVRKIIESEGLSWDYQCEELGEKTLGEICLTPTKLYVKPVLSALKTGIPIKGMAHITGGGIPENLPRCLPTDKSIEVKLDSWTIPPIFQWLKKKGNVSLEDMLNTFNMGVGFVVIVEAQEADKTIQHFQSSGIDTFLIGKVIEGKQTIIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N8</accession>
    <name>K9Z2N8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218723.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0860"/>
    <dbReference type="EnsemblBacteria" id="AFZ52992">
        <property type="protein sequence ID" value="AFZ52992"/>
        <property type="gene ID" value="Cyan10605_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0860"/>
    <dbReference type="eggNOG" id="ENOG50336PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764993_0_0_3"/>
    <dbReference type="OMA" id="TVKSNCG"/>
    <dbReference type="OrthoDB" id="1866826at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="14816" checksum="D001E1EE113EFD31" modified="2013-03-06" version="1" precursor="true">MILKFSHPFSYLWLATMVCLIYGGNMGEVQAQNQEIKGMTGGNKNSGDCGYVSDKPNYVLQLNEQAYSLNVILETQAEKPSLLILGPGEGDRFCILGDTKSGKNPQMGGVWAAGKYLIYVGDSQGSQNPFTLKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R1</accession>
    <name>K9Z2R1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD(P)H dehydrogenase, subunit NdhF3 family</fullName>
            <ecNumber evidence="10">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219168.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1324"/>
    <dbReference type="EnsemblBacteria" id="AFZ53439">
        <property type="protein sequence ID" value="AFZ53439"/>
        <property type="gene ID" value="Cyan10605_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1324"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1398"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_3"/>
    <dbReference type="OMA" id="GVGIMSF"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010217">
        <property type="entry name" value="NU5C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01960">
        <property type="entry name" value="ndhF3_CO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="139"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="629" mass="68739" checksum="A2B414E869EDA2E6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R7</accession>
    <name>K9Z2R7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsS</name>
        <name evidence="6" type="synonym">rps19</name>
        <name evidence="8" type="ordered locus">Cyan10605_0521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218394.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0521"/>
    <dbReference type="EnsemblBacteria" id="AFZ52663">
        <property type="protein sequence ID" value="AFZ52663"/>
        <property type="gene ID" value="Cyan10605_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0521"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.551"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_3"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="92" mass="10277" checksum="1862BD7C073D476F" modified="2013-03-06" version="1">MSRSLKKGPFVADSLLSKIEKLNSKGDKQVVKTWSRASTIIPQMIGHTIAVHNGRQHVPIFITDQMVGHKLGEFAPTRTFRGHAKSDKKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U4</accession>
    <name>K9Z2U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218778.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0917"/>
    <dbReference type="EnsemblBacteria" id="AFZ53047">
        <property type="protein sequence ID" value="AFZ53047"/>
        <property type="gene ID" value="Cyan10605_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0917"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.964"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_0_3"/>
    <dbReference type="OMA" id="DRCPHRN"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="39557" checksum="66EC5BA1CA906443" modified="2013-03-06" version="1">MKFEDFWYVVALSKQLKSNQVLSRQVLGEWLAIFRTKNGKPVALQDRCTHRNSRLSCGKVQQGYLQCPYHGWVYDESGGVVSIPSEGENFKPRASLKAKQYHTCEQDGFIYVCLTEEIKPQFSPFSMPYYQQPGWHYVRVVHRFNNNVTNCAENFIDIPHTVSVHPGIFRKSYQQKLEMTVTRTQGTVIANYHNEDTNLGWWTRFLNPSHHKIYHSDRFFMPNITSVEYQFAPRRHLFITSQSVPETETSTLVYTDATFSYGIWSYLATPFVSYTAKRIIGQDVKILQIQQEVIEKYGEKFAHTQADTIHVFVESIRKAIAQGKDPRTLPDKTIEVTFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W3</accession>
    <name>K9Z2W3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-3 methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218798.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0937"/>
    <dbReference type="EnsemblBacteria" id="AFZ53067">
        <property type="protein sequence ID" value="AFZ53067"/>
        <property type="gene ID" value="Cyan10605_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0937"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.986"/>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009721_2_1_3"/>
    <dbReference type="OMA" id="LMHDFCA"/>
    <dbReference type="OrthoDB" id="1195697at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_N" evidence="7">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_mid" evidence="8">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="6">
        <location>
            <begin position="261"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="405"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="651" mass="72091" checksum="04DC1830F638CD46" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z311</accession>
    <name>K9Z311_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218469.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0599"/>
    <dbReference type="EnsemblBacteria" id="AFZ52738">
        <property type="protein sequence ID" value="AFZ52738"/>
        <property type="gene ID" value="Cyan10605_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0599"/>
    <dbReference type="HOGENOM" id="CLU_2272710_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11845" checksum="2F731A324A15FAF4" modified="2013-03-06" version="1">MSEKRRKIRKSIYFEPNLNKALTLFANEYNIPTSEVVALLLAGFLISKKDIFSSELREIVEKIKPFLVYGRSIPYLENKEEPFVTLKEIIDLVEKNYDNSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z384</accession>
    <name>K9Z384_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GH3 auxin-responsive promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218781.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0920"/>
    <dbReference type="EnsemblBacteria" id="AFZ53050">
        <property type="protein sequence ID" value="AFZ53050"/>
        <property type="gene ID" value="Cyan10605_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0920"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.967"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_3_1_3"/>
    <dbReference type="OMA" id="KLISCWD"/>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="486" mass="55612" checksum="E14D022B55A05FAF" modified="2013-03-06" version="1">MSQLFIKGLSAVFFPFYQKFHLDLQDFQKAQNKVKNKVIQKLNKTAYGSKLKLKNLEDWGNIPIVDYDSLKPWIAQQRQQPNSAIITPEKIHFWECTSGSTGSKKWIPYTTSLLASFSNMFCIWAYDLISNGPAFSSGKTYLCISPEIGTTGQGIDDSKYLNPLLKWLLGKFLLRIKGHFSTVEDFRWSLACALLQAPDLETFSLWSPSFLTTQLDFIQTNNRQLQSCLVNKISSRRLSLLGESEINWSELWSELKLISCWDCNYAADSAEILKQYFPKVFLQGKGLLATEAPMTIPLIPVKGFVPLLNQVVFEFLTSEGEICNLRELEVGKTYELVISQLGGLSRYRIGDRIQVSHWHLNTPCLNFVGRGEQISDLVGEKLNIEFVRECLNNFLKWGFCCLVPVSGNPPHYCLLLEQAQEEEEEIIRKLETALQENFHYRKARQFGQLDRVKVIINPQVSQWLRGNKRLGDGKYPILVTKPLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z388</accession>
    <name>K9Z388_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218786.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0925"/>
    <dbReference type="EnsemblBacteria" id="AFZ53055">
        <property type="protein sequence ID" value="AFZ53055"/>
        <property type="gene ID" value="Cyan10605_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0925"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.972"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058593_0_0_3"/>
    <dbReference type="OMA" id="CKKYWEN"/>
    <dbReference type="OrthoDB" id="1326147at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="45970" checksum="38572C2E617CD047" modified="2013-03-06" version="1">MIASSDIIASIADDLSRLPEAKRAKKLVFYVSQRYWESDFSIVNNYSFESLLEVLYESNPTIEDLKALLYQAVNTLNRKGVYVKIAQYVYKRMSKLYTEDAQTVSNASEYQGNELEPELIDRICENIEYHEESPRIKKLIFAACKQYWENDINVIEMYDLRELVLELHELYPNAKRLRKALDKIVASINRQNFYSFIADTIIGELTYLYKHEPAEIREQGNEDEDTKLIRAKKPNQSSDISKETQIAIEQRHSVIESVEESPNPTKEEESLSIKQGTDVEPSAIPEGQVLPWLKVDSLFDLKQDIMQYTNPLRAKIVLFYTVYQIDPYEQHWSIVRTCNLDDLLIKLFQQYGKDLKLVEHHLLQVANAHIEGLEVEENIQAATALVECIKHFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z394</accession>
    <name>K9Z394_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MotA_ExbB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218913.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1058"/>
    <dbReference type="EnsemblBacteria" id="AFZ53182">
        <property type="protein sequence ID" value="AFZ53182"/>
        <property type="gene ID" value="Cyan10605_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1058"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1119"/>
    <dbReference type="eggNOG" id="COG4694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033311_0_0_3"/>
    <dbReference type="OMA" id="PRILVWA"/>
    <dbReference type="OrthoDB" id="791442at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="133"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="477" mass="53492" checksum="8074CCBB05CEE1A7" modified="2013-03-06" version="1">MGQKNNNRQELDINFLNTIIAALVLTILIYVLALPFQETYVGMLLLKRGFTQFLTVFCAFLVITITVDKYLKISKENKVFKKLGIPEEFSFENHQSVQLLHLQEDLSRTSTMITNRLRRVINAYINSGSRKTVTNFALDDSSFYLSASESSYAVPRILVWAIPLLGFIGTVLGISSAVNGFTGFLENTAEIDQIKEGIGTVTSGLAVAFDTTLLALLLSVVVMIPLVLIERMESNLLLATDIYINDYILPRLNEKQTGEKNDLNTEVIVNTINTTLEKKLPTKEELIKPIKEALPTPEELISPAQIYAQEAAKNLVTEFVNQFHKIYEQEQQLLNTIKEVNAVILEDRNKFIQTFGQQNDLNQSIITNIKELVDLVQKNNETNSQGLVEASQAISQQLNKAAVSLEEKVTSLEASSARIAELKSLQSNLEKIVEVLHNVGDIEKTLVNIQDKITNIQPTLQDLSKPRVIRLVEQIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A3</accession>
    <name>K9Z3A3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photosystem II reaction center X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psbX</name>
        <name evidence="7" type="ordered locus">Cyan10605_1562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">PSII consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. PSII forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PsbX family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219398.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1562"/>
    <dbReference type="EnsemblBacteria" id="AFZ53671">
        <property type="protein sequence ID" value="AFZ53671"/>
        <property type="gene ID" value="Cyan10605_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1562"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1659"/>
    <dbReference type="HOGENOM" id="CLU_212837_1_0_3"/>
    <dbReference type="OrthoDB" id="2082627at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01386">
        <property type="entry name" value="PSII_PsbX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009518">
        <property type="entry name" value="PSII_PsbX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023431">
        <property type="entry name" value="PSII_PsbX_type_1_subfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06596">
        <property type="entry name" value="PsbX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="37" mass="3954" checksum="51BBE96064CEECDC" modified="2013-03-06" version="1">MTASLANFLWSLVWGAAIVVIPVTIGLIVVSQADKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C6</accession>
    <name>K9Z3C6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53222">
        <property type="protein sequence ID" value="AFZ53222"/>
        <property type="gene ID" value="Cyan10605_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1100"/>
    <dbReference type="HOGENOM" id="CLU_3389013_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="32" mass="3779" checksum="A6606BA97B815A70" modified="2013-03-06" version="1">MLPVADFHLNQVIIFQNTFKTLTNQKYLLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H4</accession>
    <name>K9Z3H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219473.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1639"/>
    <dbReference type="EnsemblBacteria" id="AFZ53746">
        <property type="protein sequence ID" value="AFZ53746"/>
        <property type="gene ID" value="Cyan10605_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1639"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1740"/>
    <dbReference type="eggNOG" id="ENOG5032Z2Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161929_3_0_3"/>
    <dbReference type="OMA" id="FWIGSHA"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="10098" checksum="58BD5C4668F56C02" modified="2013-03-06" version="1">MHRTNGRFWNCFYQLPESIQILAKKNFELLKNDLNHPSLYFKKVGKFWSVRVGINYRALAFKDGEDYIWVWIGSHEEYERLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J2</accession>
    <name>K9Z3J2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219421.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1585"/>
    <dbReference type="EnsemblBacteria" id="AFZ53694">
        <property type="protein sequence ID" value="AFZ53694"/>
        <property type="gene ID" value="Cyan10605_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1585"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1683"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_3"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="30819" checksum="465737A7152F0547" modified="2013-03-06" version="1">MQPEVIGVDLGGTAIKLGRFTQDGSCLESVTIPTPQPATPKAVIDAIASMVKQLNSQNQAIAIGVGTPGPTDTQGRIALVAINLTGWENVPLADELEAKTGLKTTIANDANCAGLGEAWLGAGKNYHNSILLTLGTGVGGAIIINDKLFTGHLGAAGELGLITLNPDGPPCNSGNRGSLEQYVSATAIIRETGKNPAELATLAEQNDSTALMFWHNYGKQLGAGLASLIYILTPEVVIIGGGVSAGAKYFLSSTQKEIEKRVLPSSRINLKITVAQLGNQAGMVGAAKLAWDKGKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M0</accession>
    <name>K9Z3M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218901.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1044"/>
    <dbReference type="EnsemblBacteria" id="AFZ53170">
        <property type="protein sequence ID" value="AFZ53170"/>
        <property type="gene ID" value="Cyan10605_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1044"/>
    <dbReference type="eggNOG" id="ENOG50338GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="OMA" id="EIWITTI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12176" checksum="DC6D2F0EFE744367" modified="2013-03-06" version="1">MSQEAVVQFLDAVPENEQLQQRLVTILETSENDREDAAKLANEYGYDITPEELWAEIQKRQEEAVERQESGELTDEELEAVAGGEVVAITVAAIGAASTIFSALIPKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M4</accession>
    <name>K9Z3M4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219451.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1617"/>
    <dbReference type="EnsemblBacteria" id="AFZ53724">
        <property type="protein sequence ID" value="AFZ53724"/>
        <property type="gene ID" value="Cyan10605_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1617"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1717"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_3"/>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="454"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="526" mass="56079" checksum="DB3E862B8A9DD78C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P1</accession>
    <name>K9Z3P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219548.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1718"/>
    <dbReference type="MEROPS" id="C39.005"/>
    <dbReference type="EnsemblBacteria" id="AFZ53821">
        <property type="protein sequence ID" value="AFZ53821"/>
        <property type="gene ID" value="Cyan10605_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1718"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1825"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_3"/>
    <dbReference type="OMA" id="FAGYYAK"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="538"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50990"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53821.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="751" mass="82778" checksum="F999A343D27120BE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U5</accession>
    <name>K9Z3U5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="18">NADH dehydrogenase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Cyan10605_1302</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I subunit 5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008137">
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    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
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        <property type="entry name" value="NADH_UbQ_OxRdtase_chlpt_su5_C"/>
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        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
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        <property type="entry name" value="NU5C-like"/>
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        <property type="entry name" value="Proton_antipo_N"/>
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        <property type="entry name" value="PTHR42829"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDH_I_L"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
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            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="16">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="15">
        <location>
            <begin position="143"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_C" evidence="17">
        <location>
            <begin position="487"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001230"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="667" mass="73285" checksum="22D7AAF6ABD6F66F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U9</accession>
    <name>K9Z3U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219536.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1706"/>
    <dbReference type="EnsemblBacteria" id="AFZ53809">
        <property type="protein sequence ID" value="AFZ53809"/>
        <property type="gene ID" value="Cyan10605_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1706"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1812"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_3"/>
    <dbReference type="OMA" id="IAQTCIG"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="462" mass="50088" checksum="FA3A1AFF5393F2AA" modified="2013-03-06" version="1">MSQFEQALDKSKLTTPMWLLWILSAGLIALDGFDFFIIGIALPFLEKDFLLTPAQIGSVAVAAIFGSLIGSLTLGAITDKIGRQKMLLIDVIIFIVSSAGTALAWDAFSLIFFRFLVGIGIGADYPISVAYITENIPSRLRGRMVVGAFTFQAVGALLGALTGILVIKGCLFFSDDATIFAVQYGWRIMLGVGLILAILVGFLRMQFLLESPRYFIAKGDYQEATLAASELLDINIKITPETDPQPQENDFNYNTLFSKKYLKNTLFASLPWFLQDIATYGIGIFTPTIIAVLAFTQEDNFLLSQSQSAQGSAIVDLFLIIGFLAAVLLVDKIGRIKLQIFGFIGMALGLFLLALAGVSNSNLILVFTGFFIFNFSMNAGPNSTTFLLSGEVFPTSIRASGAGLSAAIAKSGAVLGTFLLPILRVKIGVNNVLYFLVVICLLAAVLTYFLRIETMNKPLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z6</accession>
    <name>K9Z3Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53859">
        <property type="protein sequence ID" value="AFZ53859"/>
        <property type="gene ID" value="Cyan10605_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1757"/>
    <dbReference type="HOGENOM" id="CLU_3042552_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="54" mass="6425" checksum="A8C9CDD328259E7D" modified="2013-03-06" version="1">MLIYNDFIFEIIKTIAIKVPVNYFLLIYHNYCIKADFALQKNTHTQRNCPLNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z409</accession>
    <name>K9Z409_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine--scyllo-inositol transaminase</fullName>
            <ecNumber evidence="4">2.6.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219034.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1184"/>
    <dbReference type="EnsemblBacteria" id="AFZ53305">
        <property type="protein sequence ID" value="AFZ53305"/>
        <property type="gene ID" value="Cyan10605_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1184"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1250"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_1_1_3"/>
    <dbReference type="OMA" id="INPRRYF"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047310">
        <property type="term" value="F:glutamine-scyllo-inositol transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080100">
        <property type="term" value="F:L-glutamine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="45676" checksum="16A69C2B068A5E27" modified="2013-03-06" version="1">MTLISDNLKTKIEDLAIFGGKPLFSEKQHVGRPNLGDRTQFLNRINDMLDLNWLTNRGPFVKEFEQKIADYLGVKHCVSVCNATIALELAIRALELTGEVIIPSFTFIATAHALQWQEITPVFCDIDPITHTIDPDKIESMITPRTTGIIGVHVWGQPCNIEALTTIAKKHNLKLMFDAAHAMGCSYQGKMIGSFGDAEVLSFHATKFLNSFEGGAIVTNNDELAEKLILMENFGFSGLDNVIYIGTNGKMSEVCAAMGLTSLESINEFIEINHQNYQCYQQELKDIKGIKLFTYNQQEQCNYQYIVLEIDEEITNISRDKFVDILTAENIIARRYFYPGCHRMQPYKSYFPHAGLLLPETEKLSNKVMLLPTGVNMNPDKIIKITDLIKFILDNTCSIANKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z438</accession>
    <name>K9Z438_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">Cyan10605_1797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219626.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1797"/>
    <dbReference type="EnsemblBacteria" id="AFZ53899">
        <property type="protein sequence ID" value="AFZ53899"/>
        <property type="gene ID" value="Cyan10605_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1797"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1906"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_3"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="496" mass="54766" checksum="055465DDD8523041" modified="2013-03-06" version="1">MDKYILAIDQGTTSSRALIFNKDGNVISSAQQEFTQYYPNPGEVEHDPLEIWQSVLSVVEKAIEQGNIEKKQIEGIGITNQRETTVVWNKETGKPIYNAIVWQDRRTSAKIDNLKERELQKEVKNRSGLLLDAYFSASKVEWILDHVENARNLANQGKLAFGTIDSWLIWHLTGGKKHITDVSNASRTLLLNVNKVKWDVVLLDLFNIPESMLPQLCDNSGIVAYTSSEVFGEQIPISGVAGDQQAATFGHTGFHKGIAKNTYGTGCFLISPTGKTLVPSAKSLLSTICWRFNNEITYGLEGSILASGSAITWLRDGLGIINNADEVNTLANSVPDTGDVYFVPALAGLGSPYWDQYARGTIVGIDRGTTKAHIARATLEGIAFQVYDVVKALEEDSHTPLELLTVDGGAARSDFLLQFQADILGIPVERPQEIELTAKGVGYLAGLGVGYWDNLSQIQQIKSDTKVFEPKMSENERKQRCDRWLEAVNRAKTWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z444</accession>
    <name>K9Z444_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulphatase-modifying factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218879.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1022"/>
    <dbReference type="EnsemblBacteria" id="AFZ53148">
        <property type="protein sequence ID" value="AFZ53148"/>
        <property type="gene ID" value="Cyan10605_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1022"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1083"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_9_1_3"/>
    <dbReference type="OMA" id="CRGTFRN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027577">
        <property type="entry name" value="OvoA_Nterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04344">
        <property type="entry name" value="ovoA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="192"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="52407" checksum="878DE74F53AFD2D6" modified="2013-03-06" version="1">MLLTNNHKNLILNNCTKQDIINYLNSAWETEDILFKSIQDDRTFYLNPDSLRNPLIFYLGHSAIFYINKLLIVGLLDTGINPLYEKLYEMGVDPDTPDELQNAIASIQWHDVEKLWTYRHQARNLLIDIIKKTPLELPITPESRWWAIIMGIEHQRIHIETSSMLIRQLPVELIAKPSSWYYASSKGKPPKNDMITVKGGVVNLGNPEKAYLYGWDVDFGTREVIVNDFAVSKYPITNDEFLQFVKSGGYQNSNYWQEEGWQWRETNQVTHPKFWILNQDSYRYRLMFDEIDLPLDFPVEVNHHEAIAFCNYYSQKIGQKCTMMSEAQWHLASGKNQDDENKYNLNLKYISPTPVGSIETAQSHEGIYDLRGNVWEWLADIFTPLTDFQPHYLYQDYSAPFFDNRHYLLKGGSWATNGYEATPYYRNWFRPHFFQHAGFRISNQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D4</accession>
    <name>K9Z4D4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="9" type="ordered locus">Cyan10605_1106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218959.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1106"/>
    <dbReference type="EnsemblBacteria" id="AFZ53228">
        <property type="protein sequence ID" value="AFZ53228"/>
        <property type="gene ID" value="Cyan10605_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1106"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1170"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_3"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="56"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24460" checksum="0F5B1B7CBAE7DD01" modified="2013-03-06" version="1">MAEISAKLVKELRDKTNAGMMDCKKALAENDGDMAKAMEWLRQKGITSAEKKSGRVAAEGIVESYIHTGGRIGVLVEVNCETDFVARREDFQALAKNIAMQIAACPNVEYIKISDIPEDVVAKEKEIEMGREDLASKPENIREKIVDGRINKRLGEMCLLSQPYIRDQGITVEELITQQIAKIGENIQVRRFQRFILGEGIEKEETNFAEEVAAQAGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J5</accession>
    <name>K9Z4J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219831.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2012"/>
    <dbReference type="EnsemblBacteria" id="AFZ54106">
        <property type="protein sequence ID" value="AFZ54106"/>
        <property type="gene ID" value="Cyan10605_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2012"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2138"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_11_0_3"/>
    <dbReference type="OMA" id="CTTATTQ"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938587" evidence="1">
        <location>
            <begin position="28"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="33099" checksum="8D362713C91387D6" modified="2013-03-06" version="1" precursor="true">MKNSIASQLILKLSLVFLFGLSINGCTNPTNTTTNNNSQEIISKQEPISQAERVVALTSLSADIIHQLDASKLVGVAGSSLIKQDPRFQDITTVSEGRSQPDLEKIMELKPDLVVGADGFSDQTLAKLEELGVNTVSTKVDSWLALQDTIKILAGAIDADPQPLLDSYQSLLPAKLESNISTLVLVSRQPILAPNKNSWTGDLLTQFKVNNVVADLQGSGQFSGYVTLSPEKILETNPEVIIIVDPAREGILEQLKQEDFWSELNAVKRDRIYTFDYYGLVNPGSMAKVKDTLTQLAQLTQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L6</accession>
    <name>K9Z4L6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219809.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1990"/>
    <dbReference type="EnsemblBacteria" id="AFZ54084">
        <property type="protein sequence ID" value="AFZ54084"/>
        <property type="gene ID" value="Cyan10605_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1990"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602339_0_0_3"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="52038" checksum="AB6FC3976E61054E" modified="2013-03-06" version="1">MTINITPISDQSFNLETSSTTINLLNHFDDPLTTGKVANFNLEDNSLGSGEINIVLFDQTGEGAPIAVNNFTSYVDGGSYNNSIIDRSFSTSQSKYILGGAYTVENLEVKRITPSAPIEDEFSSQRSNKAGTIAMYKLTDEANSARNRWVFNVGDNPDFDTRGGGLTVFGQVLSPEDLNTVGAIASLPVTNTSLPVINPVTSSQFSTFFSRLPVNDNTIANDFNFPYPSYPFTEDNQFVRFENITIDNVLEFTFTVESNTDPDVVSASFDNQGNLILDYGSSLKTPLYRFQNQDLPGTYLFVGEQERQSILSNFRNFKEEGLAFKTASQANGDTIKTGETDITIKATNLLGESARQSFKVSVTGDVPENENQDQLIRFNRFQNRDIPGTYLYAAEEESRNIRQNYTNFIEEGIAFYTYGADANLGQDIYRFQNTSQPGTYLFVGEEEKNSILANYPQFVLEGVAFEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M1</accession>
    <name>K9Z4M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain protein beta barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219072.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53343">
        <property type="protein sequence ID" value="AFZ53343"/>
        <property type="gene ID" value="Cyan10605_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1224"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1292"/>
    <dbReference type="eggNOG" id="COG3217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_0_2_3"/>
    <dbReference type="OMA" id="GYPFLLI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="291" mass="33225" checksum="776AF3D1DE2488FB" modified="2013-03-06" version="1">MNNLKIVNLYIYPIKSCQGIEVKSAQVTAKGLCLINNSCNCTVGDRTFMLVNEQGKFLTQREYPQLATIKVDISDNNLILSSENNDISPFELTILEENISRKVTVWRDETIGIDQGEEVAKWFKNALKLNTNCYLVKQSPQYIRPINSKYSLKENQPVSFADGFPFLLTNTASLAELNHQLKVKYPQDNLQIPMKNFRPNIVIDTDTPFIEDTWEEIEINLIKFKLVKPCSRCIIITTHQKTGARNPYKEPLLTLGNFRKTQDGIMFGQNMIALSEGVIHVSSHQTIKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q2</accession>
    <name>K9Z4Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219112.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1267"/>
    <dbReference type="EnsemblBacteria" id="AFZ53383">
        <property type="protein sequence ID" value="AFZ53383"/>
        <property type="gene ID" value="Cyan10605_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1267"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990242_0_0_3"/>
    <dbReference type="OMA" id="ISYILAW"/>
    <dbReference type="OrthoDB" id="1648552at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="33145" checksum="14A79CE7202E4047" modified="2013-03-06" version="1">MHLLLIFISLLLAYGLRILSQFISKKYQQKWGLSLFLFAFPTLILLMTCIAIICMGYQGEMWGIKASKLSYYLSISFLIYALFTLVKNTLDHLKTWSILQQCSVQKINNYKFKLLETDFPYAAQIGFWNSQLVLSQGLIKLLSQEHLLAVIAHESAHKKCRDPFLFFWLFYLKKLGFCLPNNEQLWDNLILLRELRADQIAAKKVDYLLIAESLIQVTSSIMTLPSEFNHNLECTFYDNRLQVRIDNLMAEKEDLVNNNYLEIIWLLFIFIPWLFFPFHNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S7</accession>
    <name>K9Z4S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219142.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1298"/>
    <dbReference type="EnsemblBacteria" id="AFZ53413">
        <property type="protein sequence ID" value="AFZ53413"/>
        <property type="gene ID" value="Cyan10605_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1298"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1371"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099872_1_0_3"/>
    <dbReference type="OMA" id="FYGQHPV"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23733" checksum="97472376BEF27F3C" modified="2013-03-06" version="1">MNRKGLALHTTTGELGVAFVDNQGKYYCQSWDLGRDLANQLQVKLQEFIAPLCLWSDLDFLVVAIGPGSYTSTRIGVVTAKTLAQQLNIPVYGISTLETLAWNQAINKPENSLLAIEMRANNEDVYGGIYQKKSNDLLIKILADEQLKKQKWMEIVSKYQVKFEEKIEVIFAPDKLGFTAKNLLEIAEIKINCEGIINIDSWQTLQPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z540</accession>
    <name>K9Z540_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-threonine synthase</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220021.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2210"/>
    <dbReference type="EnsemblBacteria" id="AFZ54296">
        <property type="protein sequence ID" value="AFZ54296"/>
        <property type="gene ID" value="Cyan10605_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2210"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2349"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_3"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="87"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="47218" checksum="FFFD825A230F6E53" modified="2013-03-06" version="1">MTQAIARTTDNKLKPTFTKLVSKEGSAEYPLKAIHICEETFAPLEVAYDYDAIKAQVSRESIAAGPNSIWRYKAFLPVESENPIDVGTGMTPLVKSTRLARRLGLKNLYIKNDAVNMPTLSFKDRVVSVALTRARELGFTTVSCASTGNLANSTAAIAAHAGLDCCVFIPSDLEAGKVLGTLIYNPTVMAVKGNYDQVNRLCCEVGNTYGWGFVNINLRPYYSEGSKTLGFEVAEQLGWKLPDHIVAPLASGSLFTKIYKGFQEFVKVGLVDDKAVRFSGAQAEGCSPIAQAFREGRDFVTPVKPNTIAKSIAIGNPADGMYALDIARKTNGNIESVTDAEIIEGIKLLAETEGIFTETAGGTTVAVLKKLVEAGKIDPEESTVVYITGNGLKTQEAVQGYISEPLIIEPKLDSFERALERSRTLDRLEWQQVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z570</accession>
    <name>K9Z570_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220051.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54326">
        <property type="protein sequence ID" value="AFZ54326"/>
        <property type="gene ID" value="Cyan10605_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2240"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151259_0_0_3"/>
    <dbReference type="OMA" id="WANDLNT"/>
    <dbReference type="OrthoDB" id="1844498at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15125" checksum="71F93EC0C93AF649" modified="2013-03-06" version="1">MTLTYLDSGVLITLFRASDNLALKAQEIVDDCTRKFASSDFVKLETLSKAIFHKQIDEVDFYNTFFDMCNVWANDLNTIINLAENLASKYGLNALDALQIASGISVNAEEFITTEKPTKPLHRVTDIKVISLMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K5</accession>
    <name>K9Z5K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219747.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1926"/>
    <dbReference type="EnsemblBacteria" id="AFZ54022">
        <property type="protein sequence ID" value="AFZ54022"/>
        <property type="gene ID" value="Cyan10605_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1926"/>
    <dbReference type="eggNOG" id="ENOG5033GFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692564_0_0_3"/>
    <dbReference type="OrthoDB" id="2169742at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17702" checksum="68B4BEC631D3EDD3" modified="2013-03-06" version="1">MLSNITNYTINNSLETGKNMLKELGDRAINSSNNLTDAMSKNVQSSLESLWNNWIGNHPLIGFFVSHPLIFIIVMITLVLTIWGVIQMIPSLLVRLWLSVFKSPFILGKSLLKNNQQDTLKEEFYQLILNKLDAIESKQNQLEQQLSQSKNQQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L5</accession>
    <name>K9Z5L5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MazE/toxin transcriptional modulator MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219587.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1758"/>
    <dbReference type="EnsemblBacteria" id="AFZ53860">
        <property type="protein sequence ID" value="AFZ53860"/>
        <property type="gene ID" value="Cyan10605_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1758"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_3_3"/>
    <dbReference type="OMA" id="YLCRASK"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13273" checksum="436CA7A44156B7C5" modified="2013-03-06" version="1">MSDFDVFPRQGEIYLCRASKQSGDTKKRPVVVVSLDVRNQYSSTVLVVPFSSFIEGIENNPCRVLVKKGEGGLMVDSVAMADLITNIKKNYLESSVYGVISQSYLTKIQRAISLSMGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U4</accession>
    <name>K9Z5U4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Aconitate hydratase B</fullName>
            <ecNumber evidence="5 16">4.2.1.3</ecNumber>
            <ecNumber evidence="6 16">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-methylisocitrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ordered locus">Cyan10605_1642</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="5 16"/>
    <dbReference type="EC" id="4.2.1.99" evidence="6 16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219475.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1642"/>
    <dbReference type="EnsemblBacteria" id="AFZ53748">
        <property type="protein sequence ID" value="AFZ53748"/>
        <property type="gene ID" value="Cyan10605_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1642"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1744"/>
    <dbReference type="eggNOG" id="COG1049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016536_0_0_3"/>
    <dbReference type="OMA" id="QDTTGAM"/>
    <dbReference type="OrthoDB" id="32104at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01576">
        <property type="entry name" value="AcnB_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004406">
        <property type="entry name" value="Aconitase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015933">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036288">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015929">
        <property type="entry name" value="Aconitase_B_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06434">
        <property type="entry name" value="Aconitase_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11791">
        <property type="entry name" value="Aconitase_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036687">
        <property type="entry name" value="AcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74778">
        <property type="entry name" value="SSF74778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00117">
        <property type="entry name" value="acnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 16 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase_B_N" evidence="21">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_2_N" evidence="20">
        <location>
            <begin position="171"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase" evidence="19">
        <location>
            <begin position="403"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF11791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AFZ53748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="867" mass="93866" checksum="765B8F6660595732" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z609</accession>
    <name>K9Z609_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ordered locus">Cyan10605_1912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219735.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1912"/>
    <dbReference type="EnsemblBacteria" id="AFZ54010">
        <property type="protein sequence ID" value="AFZ54010"/>
        <property type="gene ID" value="Cyan10605_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1912"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2029"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_1_3"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="20099" checksum="A490CB601D60E0A8" modified="2013-03-06" version="1">MEHKGVTIWFTGLSGAGKTTISKQVEAKLREQGYKIEVLDGDIVRTNLTKGLGFSKEDRDENIRRIGFVSQLLTRNGVIVIVSAISPYRAIREEVRAKIGNFVEVFVNAPLAVCEDRDVKGLYKKARAGEIKMFTGISDPYEPPTNPEIECRTDLEELDESVNKVLQGLEKLGYLSQPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z635</accession>
    <name>K9Z635_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54651">
        <property type="protein sequence ID" value="AFZ54651"/>
        <property type="gene ID" value="Cyan10605_2573"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2573"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2733"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="OMA" id="QIYIAIE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10897" checksum="7019BA0092FA439A" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSQFPKTEIYGLSNQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A0</accession>
    <name>K9Z6A0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prmC</name>
        <name evidence="7" type="ordered locus">Cyan10605_1831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219660.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1831"/>
    <dbReference type="EnsemblBacteria" id="AFZ53933">
        <property type="protein sequence ID" value="AFZ53933"/>
        <property type="gene ID" value="Cyan10605_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1831"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1943"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_2_0_3"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="6">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33914" checksum="CA9CA5865D873A59" modified="2013-03-06" version="1">MEFEITGKDLFNWYQSAKRDCLNNNINISELNLFIIELTSLNKLNLQLNNYQNQESINSKFSLDKLEKIWNLRITKRCPIQYLIGECHWRNFTLKVTPDVLIPRPETELIIDLASEITFNYSYLKTGNFLDLGTGSGAIALGLAEAFPNSYIYAVDKSESALKIAQENALKYGFESRVKFCHGSWFDPINDLKNSFSLIVSNPPYIPSQMVLELEPEVVNHEPKIALDGGEDGLKDIRYLIENSPNFLVKDGFLILEIMAGQGKIVENLLKENGSYKNIKIEYDLAGLDRFAIGIATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A3</accession>
    <name>K9Z6A3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220424.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2626"/>
    <dbReference type="EnsemblBacteria" id="AFZ54701">
        <property type="protein sequence ID" value="AFZ54701"/>
        <property type="gene ID" value="Cyan10605_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2626"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2789"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038906_1_0_3"/>
    <dbReference type="OMA" id="VFANGAM"/>
    <dbReference type="OrthoDB" id="801007at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="2">
        <location>
            <begin position="301"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="427" mass="48611" checksum="61CAAB7B6D2F5087" modified="2013-03-06" version="1">MSEIEQSEQLISHSRLRMRVKSPFFATLALFAQFKASYAIDTAATDGKTVFYHPEYLISLPKAQQDGLILHEILHMALLHTIRRHHRECQLWNIACDIVVNGLIAEDKNYELPPNGIRKPEWETKSVEEIYELLLQQPNESKPSLLMPDLLNQPLYDSDNEENNQAETTNKSANNQQETIDKSPKNGNQTRSKDKFLANNDINLEVELTGSIQEHKQGELKAYWQNAMQQANIVARTSNQGKLPAGMERQFKELQSAQIDWRTYLWRYLVQTPTDFQGFDRRFISHGLYLDTLAGESVQVYVCIDTSGSISDHQMNLFCSELQGILGAYPHLQCQLYYADANIYGGYELKANDDIPKPIGGGGTSFIPFFEQVEKTRDLCLQGVCVYLTDGYGDFPRDKPSLPVLWVVVPGGLDMDKFPFGEIVKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B6</accession>
    <name>K9Z6B6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220007.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2196"/>
    <dbReference type="EnsemblBacteria" id="AFZ54282">
        <property type="protein sequence ID" value="AFZ54282"/>
        <property type="gene ID" value="Cyan10605_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2196"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2334"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107610_0_0_3"/>
    <dbReference type="OMA" id="IWLVTAY"/>
    <dbReference type="OrthoDB" id="1731509at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="19180" checksum="D30CFF9AAB754D54" modified="2013-03-06" version="1">MKPISESEFNNLYQTGKLAFEKGCYRLSIENLEKACQLASFYTRVGGEARIWLVNAYEAGRETEKAIALCEELTAHPHLETRKQALKLLYILKAPQLKRPEEWMTKIPDLNADTNNLIKYNPPSNGKKIKPPPQIVLEDFSKINTKDNRFIWLSLIVSGLTLTGLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B7</accession>
    <name>K9Z6B7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1852"/>
    <dbReference type="EnsemblBacteria" id="AFZ53953">
        <property type="protein sequence ID" value="AFZ53953"/>
        <property type="gene ID" value="Cyan10605_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1852"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1965"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023681_0_0_3"/>
    <dbReference type="OMA" id="TIRFILH"/>
    <dbReference type="OrthoDB" id="757878at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="449"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="685" mass="79753" checksum="2CE39F80A8229B64" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F7</accession>
    <name>K9Z6F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219713.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53988">
        <property type="protein sequence ID" value="AFZ53988"/>
        <property type="gene ID" value="Cyan10605_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1889"/>
    <dbReference type="eggNOG" id="COG3556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092231_2_0_3"/>
    <dbReference type="OMA" id="WAIPLRK"/>
    <dbReference type="OrthoDB" id="1993992at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018706">
        <property type="entry name" value="DUF2214_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09980">
        <property type="entry name" value="DUF2214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="154" mass="17376" checksum="99F79472DFBB40EE" modified="2013-03-06" version="1" precursor="true">MWASAITAYFHYLSIGVIFASLAIEFLTLKEKLTTKEAWRIVWADSAYGAAAVVILITGILRVLYFAKDTAYYMHQPVFWAKIALYFIVGTVSLYPTISFILWVKSLLEDKAPEISLNKYKILKGIIAFELVGFTLIPLMASMMARGIGSEWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G3</accession>
    <name>K9Z6G3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2635"/>
    <dbReference type="EnsemblBacteria" id="AFZ54709">
        <property type="protein sequence ID" value="AFZ54709"/>
        <property type="gene ID" value="Cyan10605_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2635"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2799"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_3"/>
    <dbReference type="OMA" id="KSWDFHV"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="552" mass="60688" checksum="B73C3EF69A620E82" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J7</accession>
    <name>K9Z6J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase IS891/IS1136/IS1341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219905.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54180">
        <property type="protein sequence ID" value="AFZ54180"/>
        <property type="gene ID" value="Cyan10605_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2091"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2222"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="GMVFVED"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="46194" checksum="E984F2D90C89885E" modified="2013-03-06" version="1">MITLTYPFKLKVNRQQTQEIEHILSVCRSVYNYALAERKHWYNSRKSPVNSCSLISEYIIPANALYPSYNNQAKNLTVAKKTNQDLKSVNAQVLQQTLKTLDKAFSDMKSKGFGFPRFKKQMKSFVFPAMLKNCLAEGKVKLPQLGWLKIKQSRDYPTGFEAKQARIVKKATGYYLMIAFQSQESCPSAPVGKTSLGIDAGIESFVATDRGELIEAPKFLLKAQSKLKLLQRRLKHKIKGSNNWLKLQNKIAKLHEKVANTRRDWHFKLANYLCELTDNIFVEDINFTSWSRGIVRKQSLDSGIGQFINEILPFVCWKRSKFYLKVNKDGTSQECSNCGNHTGKKHLKERIHHCQYCGYTAPRDVVSAEVIKNRGLIAVGHTVNQNAYGDVLTGISQDLISLVKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M3</accession>
    <name>K9Z6M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220507.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2711"/>
    <dbReference type="EnsemblBacteria" id="AFZ54784">
        <property type="protein sequence ID" value="AFZ54784"/>
        <property type="gene ID" value="Cyan10605_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2711"/>
    <dbReference type="eggNOG" id="COG4795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084701_0_0_3"/>
    <dbReference type="OMA" id="KGGFRFC"/>
    <dbReference type="OrthoDB" id="1917135at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="26505" checksum="9E59202C61E476DE" modified="2013-03-06" version="1" precursor="true">MNRYKLLQLFLNLKKYQQKGLSLVELIVALVISGIVLTAAASGFVNVLRANQSVESKTVRSSTLARALAYMQDEIKQASSLTAVKEADDSNCNTSSGNADSEYCLRLTLPDGDSNSATTEYIYYALDDISGVTSEWLKPGVLRRRRIQEDGTDSGWWAIADGLTSVNETEPSTIACDQDSVNWTGHNTIYGGTTGGKGGFRFCVDQDPTTGESRLARIFLYGHIMGAGDGNNTISASTISFARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U9</accession>
    <name>K9Z6U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220638.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2849"/>
    <dbReference type="EnsemblBacteria" id="AFZ54916">
        <property type="protein sequence ID" value="AFZ54916"/>
        <property type="gene ID" value="Cyan10605_2849"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2849"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3028"/>
    <dbReference type="eggNOG" id="ENOG5031KNS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099780_0_0_3"/>
    <dbReference type="OMA" id="IRYHIYV"/>
    <dbReference type="OrthoDB" id="1609166at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="205" mass="24150" checksum="00AE11E83BCED918" modified="2013-03-06" version="1">MKRQFRKYKWVIVTIFSVIINLFTHYFSVHYYNGSVNVNQNELPFTRVWAQTLTPEVVSREVYQQIPDFPLENNYLSVETNQVVSENTLVSRIVRYHQYVKSRPTVYRLDWKLTLADYLGKNEIMDEQRYPSTTITENPLEKDKQVIKSLTRQQRDELVSVLVNIYNPENQEINQESTQNQQKTPSSQSPSFQLPKPGSADLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z726</accession>
    <name>K9Z726_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2286"/>
    <dbReference type="EnsemblBacteria" id="AFZ54370">
        <property type="protein sequence ID" value="AFZ54370"/>
        <property type="gene ID" value="Cyan10605_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2286"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2428"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445333_0_0_3"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="609" mass="70319" checksum="4633E90C40EAFF85" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z766</accession>
    <name>K9Z766_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2119"/>
    <dbReference type="EnsemblBacteria" id="AFZ54208">
        <property type="protein sequence ID" value="AFZ54208"/>
        <property type="gene ID" value="Cyan10605_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2119"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2253"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_3"/>
    <dbReference type="OMA" id="FSWRPDD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="225"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="690" mass="77936" checksum="2B1E10C267DCA5E6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z768</accession>
    <name>K9Z768_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220310.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2506"/>
    <dbReference type="EnsemblBacteria" id="AFZ54587">
        <property type="protein sequence ID" value="AFZ54587"/>
        <property type="gene ID" value="Cyan10605_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2506"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2656"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053953_3_1_3"/>
    <dbReference type="OMA" id="HHEAGHF"/>
    <dbReference type="OrthoDB" id="1428565at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="26444" checksum="DFDD4459B2CEE7C3" modified="2013-03-06" version="1">MEKNDIGLNILAIGIFSITLLVLVGPLLSISPFIPATITFILLSLVTVDTLAWGNQGTNLFLNLFLSEEQKQRIIHHEAGHFLTAYLYEIPIIGYTLTPWENMKINNLGSGGVMFDTSFLEEKGQDLRELNLLTERFAVVLMAGIAAEKLVYKNSEGGEEDNQKLSEIYKSLGINYSQIKIKQRLAILQAETLIEKYKDAYFALVEAMGKRLSVTECQAIIEEKKSSQLNELTPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z774</accession>
    <name>K9Z774_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD(P)H dehydrogenase, subunit NdhF3 family</fullName>
            <ecNumber evidence="10">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220770.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2991"/>
    <dbReference type="EnsemblBacteria" id="AFZ55051">
        <property type="protein sequence ID" value="AFZ55051"/>
        <property type="gene ID" value="Cyan10605_2991"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2991"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3186"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_3"/>
    <dbReference type="OMA" id="MDWGWAR"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010217">
        <property type="entry name" value="NU5C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01960">
        <property type="entry name" value="ndhF3_CO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0874">Quinone</keyword>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
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        <location>
            <begin position="72"/>
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        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="606" mass="66549" checksum="0EBD16A725341917" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z775</accession>
    <name>K9Z775_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="34" mass="4257" checksum="CDB4D9BA3CB070DC" modified="2013-03-06" version="1">MIDKQQSQPKLEQEEDINWDDYLDEEEEERETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C5</accession>
    <name>K9Z7C5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2187"/>
    <dbReference type="EnsemblBacteria" id="AFZ54273">
        <property type="protein sequence ID" value="AFZ54273"/>
        <property type="gene ID" value="Cyan10605_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2187"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2323"/>
    <dbReference type="eggNOG" id="ENOG502ZXWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="YKVMTNE"/>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9678" checksum="A94D609E9140D677" modified="2013-03-06" version="1">MKEDNLRSRKRKPRNLSEKLDAQVEKIVYKVMTNEGLEETVNTAIQKALISLIIRYSALIIIGLLLVLALQNLILVIILKSFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H8</accession>
    <name>K9Z7H8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ordered locus">Cyan10605_2258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220067.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2258"/>
    <dbReference type="EnsemblBacteria" id="AFZ54343">
        <property type="protein sequence ID" value="AFZ54343"/>
        <property type="gene ID" value="Cyan10605_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2258"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2399"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_3"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="561" mass="60418" checksum="251E6023D5B2CF19" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H9</accession>
    <name>K9Z7H9_CYAAP</name>
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        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
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    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ54535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54535">
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        <property type="gene ID" value="Cyan10605_2454"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="252"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="31094" checksum="9A208DA468335038" modified="2013-03-06" version="1">MSFKSPIIENKNPEPNKRQLLTIFFLFGGTLTFLIFLIFYLFNQLIYLVPLEVEEKIGNLIIEQIAPEKENSNISQQLNVLVDEIETLLPNKNNVKRNYEVIYVPENTVNALAIPGNKIVVYEGLLKELKSENELVMILGHEIGHFAHRDHLRSLGNMLLFKLIISSIIGDLDIFSSGVDLANVIINTQYSQRQEMKADEFGLDILNKYYGHVGGAIAFFETLEKKENNSNKLSFFSSHPSPQNRIKNLRKIIEKKDYIESQPQELNILQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I6</accession>
    <name>K9Z7I6_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2268"/>
    <dbReference type="EnsemblBacteria" id="AFZ54353">
        <property type="protein sequence ID" value="AFZ54353"/>
        <property type="gene ID" value="Cyan10605_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2268"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2409"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112741_1_0_3"/>
    <dbReference type="OMA" id="VGEGGWC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13795" checksum="4A9AF22EF84C94EB" modified="2013-03-06" version="1">MNQWRCIENCGACCNLDPSDRPDLEQYLTQEELTLYLSMVGEDGWCINYNHEQRRCNIYDDRPRFCRVKPDIFEQMYDIPLEEFEEFAIDCCHQQIEAVYGEESEEMERYISQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K8</accession>
    <name>K9Z7K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54697">
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        <property type="gene ID" value="Cyan10605_2622"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2622"/>
    <dbReference type="HOGENOM" id="CLU_1710227_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="153" mass="18159" checksum="38BE9F806B9C1C06" modified="2013-03-06" version="1">MVKNDNSLWENLDKNTCKNQKKLLDKIKSEREKLKVLLENLHDSGYEISFKNKKNNKDNENTLRIRKIINSDEKHYGLISDEVLNKNKNTNNLFGYCLDFKCDYCPNDFPYNILGFPQDNGWFIYTKKEKSKVREYIIITSIDLAHKIFNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L0</accession>
    <name>K9Z7L0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54702">
        <property type="protein sequence ID" value="AFZ54702"/>
        <property type="gene ID" value="Cyan10605_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2628"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106726_4_1_3"/>
    <dbReference type="OMA" id="RHRRIEF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="16275" checksum="98C0AF4B181365C5" modified="2013-03-06" version="1">MVIKLTASEEIKEVAQNLLNHKFKINVLKLEEHETVNIPVDLANFVEQIIREVAEGNSITLVSNHQEISTTEASEILEVSRQHLIELLESGELPIPFRRVGKHRRLRAEDVINYKNKIDEQRLKTLEELAKQAQELKLGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M2</accession>
    <name>K9Z7M2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photosystem I reaction center subunit PsaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Photosystem I subunit X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psaK</name>
        <name evidence="10" type="ordered locus">Cyan10605_2643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 11-88</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PsaG/PsaK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220440.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="9/K/k=11-88"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z7M2"/>
    <dbReference type="STRING" id="755178.Cyan10605_2643"/>
    <dbReference type="EnsemblBacteria" id="AFZ54717">
        <property type="protein sequence ID" value="AFZ54717"/>
        <property type="gene ID" value="Cyan10605_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2643"/>
    <dbReference type="eggNOG" id="ENOG5032YIH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160496_1_0_3"/>
    <dbReference type="OMA" id="ANCLGHI"/>
    <dbReference type="OrthoDB" id="2053688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.860.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00474">
        <property type="entry name" value="PSI_PsaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035982">
        <property type="entry name" value="PSI_centre_PsaK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000549">
        <property type="entry name" value="PSI_PsaG/PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017492">
        <property type="entry name" value="PSI_PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037101">
        <property type="entry name" value="PSI_PsaK_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01241">
        <property type="entry name" value="PSI_PSAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81563">
        <property type="entry name" value="SSF81563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03049">
        <property type="entry name" value="PS_I_psaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01026">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="88" mass="8945" checksum="E5E5400D5C79001D" modified="2013-03-06" version="1">MLYLNSLLATAVPTTLEWNLNVGLTMIVCNIVAIAFAKYTVKEPGAGPKLPGEAFFGGMGLPALLATTSFGHLLGAGVILGLASLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X4</accession>
    <name>K9Z7X4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220559.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2769"/>
    <dbReference type="EnsemblBacteria" id="AFZ54837">
        <property type="protein sequence ID" value="AFZ54837"/>
        <property type="gene ID" value="Cyan10605_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2769"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055243_0_0_3"/>
    <dbReference type="OMA" id="ADVHGRC"/>
    <dbReference type="OrthoDB" id="499443at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="276" mass="32434" checksum="E59B90BE0B0FF3D4" modified="2013-03-06" version="1">MAFILIKGRFHVVGYSPDGDSIRFQAYNLEHWSKLQGISPELNEENHAQIRLIGIDSLETHFRQCQQSVKWALNAAHFLLESLEIDEVKWNEEKNIIISAQDKIEGFILVKKTDQHGRPLAFVFKGEIDHPDGEEFFLPINLFFESVNYQSLLSGQSYPTYYRGIAPTLRKKMTWAVNQARKNKKGLWEFDLTNHGFNVWDLFDEEKTVIILPKLFRRLVSYLETSDNLDYFKHSVVKSEKVLILPNKRKKLFRDIIIQDEHFFKLSELPEDLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z8</accession>
    <name>K9Z7Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3222"/>
    <dbReference type="EnsemblBacteria" id="AFZ55269">
        <property type="protein sequence ID" value="AFZ55269"/>
        <property type="gene ID" value="Cyan10605_3222"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3222"/>
    <dbReference type="HOGENOM" id="CLU_3403100_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="30" mass="3581" checksum="C647D97D5138F00C" modified="2013-03-06" version="1">MEKIPDLFFSNHKLLVIVKSRNFECADEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A4</accession>
    <name>K9Z8A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BFD domain protein (2Fe-2S)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221144.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3384"/>
    <dbReference type="EnsemblBacteria" id="AFZ55426">
        <property type="protein sequence ID" value="AFZ55426"/>
        <property type="gene ID" value="Cyan10605_3384"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3384"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3602"/>
    <dbReference type="eggNOG" id="COG2906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159205_3_3_3"/>
    <dbReference type="OMA" id="CTEYACK"/>
    <dbReference type="OrthoDB" id="1969696at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="6454" checksum="5CBC37AC2C6B6C11" modified="2013-03-06" version="1">MYVCICNGVTEKDIHKAVEGGICSLDQLSAKTSVTKHCGCCTEYACKVIEEAMAQRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G9</accession>
    <name>K9Z8G9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ordered locus">Cyan10605_2813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220602.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2813"/>
    <dbReference type="EnsemblBacteria" id="AFZ54880">
        <property type="protein sequence ID" value="AFZ54880"/>
        <property type="gene ID" value="Cyan10605_2813"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2813"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2990"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_3"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="66"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="413" mass="45072" checksum="9714435D5AFDC081" modified="2013-03-06" version="1">MTVTPIKNNKFTQVPDNLGRFGQYGGKYVPETLMPALTELETAYYQYKEDPDFKNELNQLLKDYVGRENPLYFAERLTQHYAKPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKRMGKKRIIAETGAGQHGVATATVCARFGLQCVIYMGVEDMERQKLNVFRMRLLGATVQPVSAGTGTLKDATSEAIRDWVTNVENTHYILGSVAGPHPYPMMVRDFHGVIGKETRKQCLEKWGGLPDILIACVGGGSNAMGLFYEFVDESSVRLIGVEAEGSGINTGKHAATLTHGKPGVLHGAMSYLLQDNQGQVVEAHSISAGLDYPGVGPEHSYLKDLGRAEYYSVTDAQALDAFQLVCKLEGIIPALETAHAFAYLETLCPQVSGSPRIVINCSGRGDKDVQTVAKHLKGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V6</accession>
    <name>K9Z9V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220872.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3100"/>
    <dbReference type="EnsemblBacteria" id="AFZ55153">
        <property type="protein sequence ID" value="AFZ55153"/>
        <property type="gene ID" value="Cyan10605_3100"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3100"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3303"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_0_2_3"/>
    <dbReference type="OMA" id="NAQGKYN"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoB-type G" evidence="1">
        <location>
            <begin position="37"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="22093" checksum="F56266B73213160B" modified="2013-03-06" version="1">MNCHQCQSTTCHSHSKNNWFTSLFKKKKTQTIERETTGKIALVGMPNVGKSVLFNALTGIYVDISNYPGTTVEISHGKFQIDNDYFSIIDTPGMYSLLPITEEERVARDLLLQDSLSLAIHVVEAKNLARMLTLTFQLIEAGFPTLLAVNMIDEAEKLKIKIDPLTLEDELGIPVIKMSAATGFGLDQLKRRILSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9X1</accession>
    <name>K9Z9X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3481"/>
    <dbReference type="EnsemblBacteria" id="AFZ55517">
        <property type="protein sequence ID" value="AFZ55517"/>
        <property type="gene ID" value="Cyan10605_3481"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3481"/>
    <dbReference type="HOGENOM" id="CLU_2914787_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="7011" checksum="D938169B9F491364" modified="2013-03-06" version="1">MSLKYLLDTNIISEAKRPLPNQNVIKNLSLYSQEIATAMSLMDLDLKHDEFIHTIKFLSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA78</accession>
    <name>K9ZA78_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221218.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3463"/>
    <dbReference type="EnsemblBacteria" id="AFZ55500">
        <property type="protein sequence ID" value="AFZ55500"/>
        <property type="gene ID" value="Cyan10605_3463"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3463"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3688"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327247_0_0_3"/>
    <dbReference type="OMA" id="LIFAHNT"/>
    <dbReference type="OrthoDB" id="35904at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029457">
        <property type="entry name" value="GHL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14872">
        <property type="entry name" value="GHL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="836" mass="97692" checksum="D9FCC96C3A4E2F28" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA90</accession>
    <name>K9ZA90_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_3237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221001.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3237"/>
    <dbReference type="EnsemblBacteria" id="AFZ55283">
        <property type="protein sequence ID" value="AFZ55283"/>
        <property type="gene ID" value="Cyan10605_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3237"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3451"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047345_0_0_3"/>
    <dbReference type="OMA" id="WCPHCHE"/>
    <dbReference type="OrthoDB" id="1187526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12916">
        <property type="entry name" value="VKOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044698">
        <property type="entry name" value="VKOR/LTO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="339" mass="37246" checksum="742A0A16DC4AB1EC" modified="2013-03-06" version="1" precursor="true">MLRRRNQTWIQKKSRLIIGAIAIVGLILTLYLTITKLAGGEVACTTEVANTAAGCSSVLDSAYAYPFDPQGKTGPPLSLFGSLAYLVMAIFALSPLFINPEKSKQLRLSLEKWTWWGMLVGSFAMATFSAYLMYVLAFELQTVCYYCIGSALFSLSLLTLTIIGNDWEDMGQIIFTGVAIALITLVSTVGVYANVNADVATNQPATEISQNGKIIITRPTVEAKPPIGWEITTTSGESEIALAKHLAQSDAVMYSAYWCPHCYDQKQLFGQEAFNNHLKKIECAPDGLKGEPQKCVDANIRAFPTWIIQGQVYEGVQSLEKLAELTGYTGEQNFKYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAE6</accession>
    <name>K9ZAE6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221071.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3308"/>
    <dbReference type="EnsemblBacteria" id="AFZ55353">
        <property type="protein sequence ID" value="AFZ55353"/>
        <property type="gene ID" value="Cyan10605_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3308"/>
    <dbReference type="eggNOG" id="ENOG5031501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112010_1_1_3"/>
    <dbReference type="OMA" id="AWKTFTR"/>
    <dbReference type="OrthoDB" id="1943186at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="13761" checksum="3E15C05BB21121DE" modified="2013-03-06" version="1" precursor="true">MNEPLFWLGLSLCLVATSLTAVLIALIPVVQELSRAARSAEKLFDTLNREFPDTLEAIRVTNIEITELSEEMKGGVKSASGAVQKVDRTLINAKKQVESAQTKSKSFWIGLKTGFQTWKNYDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAI7</accession>
    <name>K9ZAI7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_3366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55408.1"/>
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    <dbReference type="EnsemblBacteria" id="AFZ55408">
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        <property type="gene ID" value="Cyan10605_3366"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.3584"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
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        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="recQ"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="222"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="523"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="707" mass="81847" checksum="0A12081CD019C72F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ90</accession>
    <name>K9YZ90_CYAAP</name>
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        <submittedName>
            <fullName evidence="4">rRNA (Guanine-N(2)-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0092"/>
    <dbReference type="EnsemblBacteria" id="AFZ52251">
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        <property type="gene ID" value="Cyan10605_0092"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.94"/>
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    <dbReference type="OrthoDB" id="1772619at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0034470">
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    </dbReference>
    <dbReference type="GO" id="GO:0001510">
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
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        <property type="entry name" value="THUMP_dom"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="374" mass="42417" checksum="B3FA7A0A50889B00" modified="2013-03-06" version="1">MTTSYFATTSRGLEEITAQELTTLGAKEVKTDFTGVHFQGDKELLYRVNLWGRTIFRVLKPIATIKSQTPQQLFRNVQKIDWSEFLQPQQTLAIRCTGKNDQLNHSHFTAIQIKNAIVEQQQKYHKVRSNIDTNSPDIVINAHIHHDECILSLDSTGESLHRRGYRPAVGLAPLKETLAAALLYIAEWDSSIPLYDPFCGSGTILIEGALMGLNIAPGLYRHQFCFENWQDYDHNLWQNLIDEARKSQKIDLPPIVGTDIDSSIIKQAQHNAKTCQIANHVEFFQRHLVDATPPAESGILICNPPYGKRLEDTEALFPLYKLLGDILKQRFKGWTAYILTGNKLLTKKVGLRTSRRIAINNGGIDCTLLKYELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z013</accession>
    <name>K9Z013_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0402"/>
    <dbReference type="EnsemblBacteria" id="AFZ52546">
        <property type="protein sequence ID" value="AFZ52546"/>
        <property type="gene ID" value="Cyan10605_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0402"/>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2381364_0_0_3"/>
    <dbReference type="OMA" id="DAVYIRI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10793" checksum="CE3171D9D2EA1D43" modified="2013-03-06" version="1">MIGVTNMIRISEYDPEVDAIYVQLHEDDVLDSEEIEKGIIVDYNKYNKVIGFELLGIRNISISSLQSLKSLLSSDEIAMLQEFNIFSQIFLMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z045</accession>
    <name>K9Z045_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218270.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0395"/>
    <dbReference type="EnsemblBacteria" id="AFZ52539">
        <property type="protein sequence ID" value="AFZ52539"/>
        <property type="gene ID" value="Cyan10605_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0395"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.418"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_1_3"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="20490" checksum="B25737F3E465942B" modified="2013-03-06" version="1">MFGIPELPQILGSKLFFQGKKFQFEVNKLRLPNGAEGEWECIRHPGGALAVPITNDGKLVLVRQYRFAVKTRLLEFPAGTVESEEAPETTIKREIEEETGYRAKKWRSLGKFPLAPGYSDEFIFAFLAQDLEKLAQPPKQDDDEDIEVVLMTPAEFEDLAMTSNQIDAKTICSYFLALPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I2</accession>
    <name>K9Z0I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218400.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0527"/>
    <dbReference type="EnsemblBacteria" id="AFZ52669">
        <property type="protein sequence ID" value="AFZ52669"/>
        <property type="gene ID" value="Cyan10605_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0527"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_2_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="11471" checksum="FCAD1604D4B8E880" modified="2013-03-06" version="1">MLIALDHQINNSQIEVGELMTVVVVRATNAAKDFFENIKNVTGGKMTHYESLIQNALKEALKLLDEEAKQKGYDGVIGVKICHPTVVVGGVEIIVYGNGFKNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S1</accession>
    <name>K9Z0S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218059.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0170"/>
    <dbReference type="EnsemblBacteria" id="AFZ52327">
        <property type="protein sequence ID" value="AFZ52327"/>
        <property type="gene ID" value="Cyan10605_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0170"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.178"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063207_1_0_3"/>
    <dbReference type="OMA" id="IGNYQAK"/>
    <dbReference type="OrthoDB" id="900615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="43150" checksum="FA19CB96232909F9" modified="2013-03-06" version="1">MAINSKNTKAEILSAYKELEKEKTELENKLKAGQNLNLPLEKTPPIPENKTTDQKKNTDKNEEKTMNISNANISQIIQNLETLQVSFGGAVSQLSEQLITEASTVEKLQTEIQGEIDKLRELHDLETIEENTLDELINNYQTSEENFILEYSQREESLRQELENLSKEWQKEQETKQREIKIRNDNYNTNKQREQDEYYYNLQLERQLNQESYEQEINNFYKELEETKQQQEKVWEEREKAIFEKEKEYEETKQKVKEFEEKLSLEIKKAKEEGKGIGTYQAKVKADLRQKEIEGETQNYLLRIQALESTINNNENRINNLSHQLESALKQVQDLAVKAIEGTSNRNSFEAMKEVALEQAKNQQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T2</accession>
    <name>K9Z0T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218537.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0668"/>
    <dbReference type="EnsemblBacteria" id="AFZ52806">
        <property type="protein sequence ID" value="AFZ52806"/>
        <property type="gene ID" value="Cyan10605_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0668"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.704"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169009_1_0_3"/>
    <dbReference type="OMA" id="FFDDYSG"/>
    <dbReference type="OrthoDB" id="1864676at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11186" checksum="CDC93F336E53C92F" modified="2013-03-06" version="1">MTQQASKLVIVTEKLLLKPIAKIIDAAGASGYTVVAAGGKGSRNVRSSGQPSVSDTYSNIKIEVLTANREMALKISDEVAAQFFNDYSGIIYICEAEVLYAHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U8</accession>
    <name>K9Z0U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delta-9 acyl-phospholipid desaturase</fullName>
            <ecNumber evidence="9">1.14.19.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217907.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0014"/>
    <dbReference type="EnsemblBacteria" id="AFZ52175">
        <property type="protein sequence ID" value="AFZ52175"/>
        <property type="gene ID" value="Cyan10605_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0014"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.15"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_0_3"/>
    <dbReference type="OMA" id="SCGESWH"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="31774" checksum="3052C1926308E34F" modified="2013-03-06" version="1">MTATTTTEKLAPAWSVIIYMTSIHLIALLAFLPSNFSWGAVGITAFLYWLTACIGVTLGYHRLVSHRSFETPKWLEYFLVFCGTLACEGGPISWVGLHRIHHKYSDHEGDPHDSNKGFWWSHMGWMFVKNPANNDVPKYTKDIQNDPFYVFCEKYFIPIQVVLGLLLFWWGGWSFVVWGIFLRLVLVFHVTWFVNSATHKFGYKSHESNDHSRNCWWVALLTFGEGWHNNHHAFQYSARHGLQWWEIDLTWMTIKLLAFFGLAKNIKLAPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V8</accession>
    <name>K9Z0V8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="8" type="ordered locus">Cyan10605_0218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218104.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0218"/>
    <dbReference type="EnsemblBacteria" id="AFZ52372">
        <property type="protein sequence ID" value="AFZ52372"/>
        <property type="gene ID" value="Cyan10605_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0218"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.227"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_0_3"/>
    <dbReference type="OMA" id="PWQDPHN"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="38466" checksum="BB6EC4A5DA440D0B" modified="2013-03-06" version="1">MGKSVWSLDHARLHKLLKDKDLVAKSSRILIAVSGGQDSLCLARLCLDLQSKWSWKIAIAHFDHQWECDRGLSSHIAKICDDWGVNFYLSQAQEKIREREGEARKYRYEALINIATEYDFNYLLTGHTRSDRAETFIYNLMRGAGIEGLTALNWRRKINENLTLVRPLLDFTRQETGQFCHKWQLPVWEDKYNQERKFARNRIRLDLIPYLQTEFNPQIEKHLTQTAEILRADLTYLKQETTRLYEQVYNHENNSLKCEELRKISLNFQRRIVKDFLVQNLQKMPNFEQIEAVVKLIESPNLTATSTLIKNKIAQVKNREILIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z145</accession>
    <name>K9Z145_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218615.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0751"/>
    <dbReference type="EnsemblBacteria" id="AFZ52884">
        <property type="protein sequence ID" value="AFZ52884"/>
        <property type="gene ID" value="Cyan10605_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0751"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.789"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_1_3"/>
    <dbReference type="OMA" id="LWQANEH"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16759" checksum="0B2DF04490E81399" modified="2013-03-06" version="1">MKPHGVETKKMRSLKDALNRCQELGLRISRQRRFILELLWEEKNHLCAKEIYEKLSQQGKHIGYTAVYQNLEILSQNGIIECVDKHGSRLYSNLGDEHSHLNIIDTDQIVDIQVELPPDLIKNIEAKTGVKVAHYRIDFYGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z180</accession>
    <name>K9Z180_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218692.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0829"/>
    <dbReference type="EnsemblBacteria" id="AFZ52961">
        <property type="protein sequence ID" value="AFZ52961"/>
        <property type="gene ID" value="Cyan10605_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0829"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.872"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_3"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="36557" checksum="7A6F13132D361584" modified="2013-03-06" version="1">MAILITGGAGYIGSHTVKLLQNRDYDILVFDNLVYGHRDIVEKLGVSFIEGDLCDRTLLDDLFQEHNIEAVIHFAAYAYVGESVENPAKYYRNNVTYTLNLLEAMEKAGIRKIVFSSTCATYGIPEEVPIKETHPQNPINPYGYTKLVVEKMLSDFQRAYNWEYVAFRYFNAAGASSDGLIGEDHNPEPHLIPLILYAALGKRDSISILGDDYPTPDGTCIRDYIHVEDLAQAHLLGLEYLLDGGKSEVFNLGNGNGFSVKEVIKAAKKVTGKDFTVKNAPRRPGDPPILVGSSEKAKKILNWQPQYPDIETIISHAWQWHQSRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z181</accession>
    <name>K9Z181_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218052.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0163"/>
    <dbReference type="EnsemblBacteria" id="AFZ52320">
        <property type="protein sequence ID" value="AFZ52320"/>
        <property type="gene ID" value="Cyan10605_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0163"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.169"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_0_2_3"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="744"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="903" mass="99105" checksum="C11461DF4D2CD9BC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z183</accession>
    <name>K9Z183_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Cyan10605_0791</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218655.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0791"/>
    <dbReference type="EnsemblBacteria" id="AFZ52924">
        <property type="protein sequence ID" value="AFZ52924"/>
        <property type="gene ID" value="Cyan10605_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0791"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.832"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_10_3"/>
    <dbReference type="OMA" id="KFWFDLD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="363"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="448"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="697"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ52924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="899" mass="102955" checksum="129A8712874D8238" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J9</accession>
    <name>K9Z1J9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218338.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0465"/>
    <dbReference type="EnsemblBacteria" id="AFZ52607">
        <property type="protein sequence ID" value="AFZ52607"/>
        <property type="gene ID" value="Cyan10605_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0465"/>
    <dbReference type="HOGENOM" id="CLU_1988942_0_0_3"/>
    <dbReference type="OMA" id="DCPACIN"/>
    <dbReference type="OrthoDB" id="1895340at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="16204" checksum="6EDC9B335DC5F9F0" modified="2013-03-06" version="1" precursor="true">MNINSSLKILLLSSPAVIGTLFLNLVYGDSVQALDLLNSEGSISTSNPSPSNLNCDRSFCTGNQYLAAFPQVDQQESVNQFPNVEQNEEGHLLLDVTEEESDTAVQMFGCDCVKAINALRQLRGIPVGVEGDRILPGPLIRPCTQRLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P0</accession>
    <name>K9Z1P0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="3" type="synonym">rpl17</name>
        <name evidence="6" type="ordered locus">Cyan10605_0500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218373.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0500"/>
    <dbReference type="EnsemblBacteria" id="AFZ52642">
        <property type="protein sequence ID" value="AFZ52642"/>
        <property type="gene ID" value="Cyan10605_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0500"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.530"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_2_3"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="13054" checksum="3894992D8BD9D184" modified="2013-03-06" version="1">MRHRRKVPLLGLPADQRKALLRALTTQLLREGEIVTTKARAKAVRTTADKMITLAKDGSLSARRQALGYIYDKDLVNDIFAKATERYGNRNGGYTRVVRTKSRRGDNAEMAIIQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V0</accession>
    <name>K9Z1V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF sensor signal transduction histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218296.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0421"/>
    <dbReference type="EnsemblBacteria" id="AFZ52565">
        <property type="protein sequence ID" value="AFZ52565"/>
        <property type="gene ID" value="Cyan10605_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0421"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.445"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_3"/>
    <dbReference type="OMA" id="IWQQTVD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="2">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="309"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="554" mass="62691" checksum="232180701DF23F2A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z242</accession>
    <name>K9Z242_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded nucleic acid binding R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218990.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1139"/>
    <dbReference type="EnsemblBacteria" id="AFZ53261">
        <property type="protein sequence ID" value="AFZ53261"/>
        <property type="gene ID" value="Cyan10605_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1139"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_4_1_3"/>
    <dbReference type="OMA" id="RGKEPHR"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="18497" checksum="01B8822BEACB754E" modified="2013-03-06" version="1">MDEQIQRGKKWLETLLTLMGVPASVTIGRVEQEERAISCWLTIDETKLTPTVIENLIGKKGETIDALQYLANVLLNIGVLDGEERFFTVELNGYRIRRQAELMAIAQKAADRVRITGMPEEIRYLSSVERRQVHSFLEKSGDLATESEGNEPDRRLIVKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z274</accession>
    <name>K9Z274_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218224.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0346"/>
    <dbReference type="EnsemblBacteria" id="AFZ52493">
        <property type="protein sequence ID" value="AFZ52493"/>
        <property type="gene ID" value="Cyan10605_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0346"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.362"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_3"/>
    <dbReference type="OMA" id="PFHMLQR"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="26700" checksum="4162059C24DCED81" modified="2013-03-06" version="1">MVLKAILFDFNGVIVNDEIIHQKLIDELLLRENLPPSGNQYQKFCLGRSDRACIKDILEARGRVIGEEYLDKLIQRKAQDYRRILEEMEKLPSCDRITEFILSLQSRHLSLGIVTGALRTETEYILEKMNICQYFSVIVAGDDIKTSKPSGDGYLLAVEKINQQNPSLELKPSECLVIEDTPAGIEAGKNAGMAVVGVANTYPLHLLQRQANWCVDNLMQLDLDWINDTMKANFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B5</accession>
    <name>K9Z2B5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms protein Csm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219075.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1227"/>
    <dbReference type="EnsemblBacteria" id="AFZ53346">
        <property type="protein sequence ID" value="AFZ53346"/>
        <property type="gene ID" value="Cyan10605_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1227"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1295"/>
    <dbReference type="eggNOG" id="COG1567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062371_0_0_3"/>
    <dbReference type="OMA" id="YFSHFEF"/>
    <dbReference type="OrthoDB" id="2044338at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005510">
        <property type="entry name" value="Csm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040932">
        <property type="entry name" value="Csm4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17953">
        <property type="entry name" value="Csm4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01903">
        <property type="entry name" value="cas5_csm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Csm4_C" evidence="5">
        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="41683" checksum="61AE1BF32765536E" modified="2013-03-06" version="1">MSNWKLIHLNFTKNLAHFGEVGIGLEETQERVKSDTLFSALITSYARLFGKKEVEDLLNQINQNPHLFRHSSTFIYHRNQDKFTYYLPKPLLFPKNYPIKDDLAFTKTYKKLKHLPLTIWQKWYQKADFTQDDIEELTSKTQGKNNSHNYLAQQGVFDYQNNFEIKKNPKVAIDRNDSSTNFYHTGFVQYNYQDEKEYSGLYFLINFAENTKELEIKICAALHLLAEEGIGGEKSSGAGRFTPEWLELPPQWQDVINFNQGDLYSLISLFWNSSISSEIIDKSYYEIQERGGWIGSPFSGRQLRRKMVRMFTEGSVFSTIPQGELADVTPSDFKKVHKVYRSGISLSLPIQVQLTSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H3</accession>
    <name>K9Z2H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53401">
        <property type="protein sequence ID" value="AFZ53401"/>
        <property type="gene ID" value="Cyan10605_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1286"/>
    <dbReference type="HOGENOM" id="CLU_3250296_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="42" mass="4802" checksum="F2EFDD6096CECCBD" modified="2013-03-06" version="1">MVLGYWGVLSPLNSLYYKDETISEWVSQFIILTPNPSPKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H7</accession>
    <name>K9Z2H7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219083.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1235"/>
    <dbReference type="EnsemblBacteria" id="AFZ53354">
        <property type="protein sequence ID" value="AFZ53354"/>
        <property type="gene ID" value="Cyan10605_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1235"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_6_1_3"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10572" checksum="B5FC061150B4ABDE" modified="2013-03-06" version="1">MYKIEYSKTAIKKLNKIPKNLVKRIQNKLTEIAQNPYRENPNLKKLVGREGYRLRIGDWRIIYEINNDRIVILVLYQIRLISHTKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q3</accession>
    <name>K9Z2Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219215.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1373"/>
    <dbReference type="EnsemblBacteria" id="AFZ53486">
        <property type="protein sequence ID" value="AFZ53486"/>
        <property type="gene ID" value="Cyan10605_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1373"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1450"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_3"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="147"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="362" mass="38975" checksum="1C631BBC275A73AE" modified="2013-03-06" version="1">MKIGVPKEIKDREFRVGLTPASAKVLIEQNHQVFIEDNAGLGSGFTNQDYENIGANIVDQSTAWNQELIIKVKEPLAEEYQYINQGQILFTYLHLAADRILTEFLLKSGVTAIAYETVQLADGRLPLLTPMSIIAGRLSVQIGARYLEKQQGGKGILLGGMPGVTQGNVVILGGGIVGTEAAKIAVGMGAKVTILDVNIDRLSYLETLFGSRVELLYSNSQHIAQVVPHADLLIGAVLITGRKAPILVSRDLVKQMSPGSVILDVAVDQGGCIETLRTTSHSQPSYEEEGIIHLGIPNLPGAVPRTATQALNNNTLPYIVKLANQGIGALKQDPSLAQGLNIQYHRLVHPAVQQVFPDLVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q5</accession>
    <name>K9Z2Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
            <ecNumber evidence="3">1.14.14.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.14.18" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218738.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0877"/>
    <dbReference type="EnsemblBacteria" id="AFZ53007">
        <property type="protein sequence ID" value="AFZ53007"/>
        <property type="gene ID" value="Cyan10605_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0877"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.922"/>
    <dbReference type="eggNOG" id="COG5398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057050_2_0_3"/>
    <dbReference type="OMA" id="KKSHTMA"/>
    <dbReference type="OrthoDB" id="1371367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="27642" checksum="BBDFB137379726D7" modified="2013-03-06" version="1">MTVNLATMLKEGTKKSHSMAENMGFIKCFLKGVVEKNSYRKLAANLYFVYGAMEEEMERLKDHPIVGKIYFPELNRQPSLAKDLQFYYGANWKNEIQITPAGQAYVDRIHEIANNQPELFAAHSYTRYLGDLSGGQILKNIAQKAMNLDGEGTAFYEFETISDEKAFKNMYRQALNDLPVDEATAEKIVDEANDAFAMNMKMFQELEGNLIMAIGKMLFNTLTSRRRRGSTQSDNQGELATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R6</accession>
    <name>K9Z2R6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219173.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1329"/>
    <dbReference type="EnsemblBacteria" id="AFZ53444">
        <property type="protein sequence ID" value="AFZ53444"/>
        <property type="gene ID" value="Cyan10605_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1329"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261594_0_0_3"/>
    <dbReference type="OMA" id="WLESHEY"/>
    <dbReference type="OrthoDB" id="393776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="PTHR21529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="2">
        <location>
            <begin position="161"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1221" mass="146641" checksum="B9DA942FC4721ADB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S9</accession>
    <name>K9Z2S9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ordered locus">Cyan10605_1345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219188.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1345"/>
    <dbReference type="EnsemblBacteria" id="AFZ53459">
        <property type="protein sequence ID" value="AFZ53459"/>
        <property type="gene ID" value="Cyan10605_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1345"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1419"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_3"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="30787" checksum="F9AC58EAD46B44AA" modified="2013-03-06" version="1">MRILISNDDGIFAKGIRTLANAIASCDHEVVVVAPDRERSATGHGLTLHQPIRADIIEGIFHEKVTAWSCSGTPSDCVKLALSAILKDNPPDFVLSGINQGSNLGTDILYSGTVSAAMEGTMEGITSIAFSLASFTIKEFQPAANYALKLIQQLIENPLPEATLLNVNIPPVSEPEIKGVKITRQGIRRYTENFQQRFDPRGKSYYWLAGEVVEEIEQPEHIYLPPDLPTDVQANKDNYITITPLQYNLTDVVTVQRLEQKLDLSINYFSLARSKGFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y5</accession>
    <name>K9Z2Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219248.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1407"/>
    <dbReference type="EnsemblBacteria" id="AFZ53519">
        <property type="protein sequence ID" value="AFZ53519"/>
        <property type="gene ID" value="Cyan10605_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1407"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1487"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_4_1_3"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10151" checksum="447E1000CE39FF19" modified="2013-03-06" version="1">MKRIVKDFLHDILDTINSINRFIDSLNFDDFCEDEKTIFAVIHGLERIGEATKKVTDNLPYVKEKYSNMNWKEIAGMRDILINLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z302</accession>
    <name>K9Z302_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218459.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0589"/>
    <dbReference type="EnsemblBacteria" id="AFZ52728">
        <property type="protein sequence ID" value="AFZ52728"/>
        <property type="gene ID" value="Cyan10605_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0589"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.621"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042257_1_0_3"/>
    <dbReference type="OMA" id="PRHYGPW"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="167"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="362" mass="40770" checksum="925134FE807AF480" modified="2013-03-06" version="1">MKIAQVAPLWESVPPNRYGGIELVVALLTDELVRRGHDVTLFASGDSQTLAKLESVYPRAIRTDKQVKDYNAYLTLQLQKVYSRANEFDLIHSHVDYHALPYANFVKTPTIHTLHGEFTQENKLLFSQSKHQNYVSISQSQREPLPDLNYVGNVYNGIDVNSYQFFPQPDDEPYLAFLGRVSPQKGPHLAIQIAKKTGWKLKMACKVDPVDQEFFETQVLPHVDGQQIQLLGEVDSKEKNKLIGGARATLFPITWREPFGLVMAESMASGTPVIAMSLGSAPEVIADGKTGFLCHNIEEMILAVDKISQVNRYDCRNHVLKNFGVSRMVDSYEEVYRQVLAQRFNNINGHLIDSHIDLATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z347</accession>
    <name>K9Z347_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
            <ecNumber evidence="2">3.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EC" id="3.5.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218873.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53142">
        <property type="protein sequence ID" value="AFZ53142"/>
        <property type="gene ID" value="Cyan10605_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1014"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1072"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_3"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050118">
        <property type="term" value="F:N-acetyldiaminopimelate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="188"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="392" mass="42842" checksum="1F01A3315EE99EA8" modified="2013-03-06" version="1">MLDKIKDIAQEIAPRLIEIRRHFHAHPELSGQEYQTAAYVAGVLSSCGLSVQEGIGKTGVIGELKGNGSQDRTLAIRTDMDALPIHEATSLDFVSRVPGVMHACGHDVHTTVGLGTAMILAQMCDRIDGNIRFLFQPAEEIAQGALWMVADGAMKDVDAIFGVHVFPTIPARSVGIRYGALTSAMDDLEIIIQGEAGHGARPHQAIDAIWISAQVITALQQAISRTHNPLHPLVLTIGQINGGSAPNIIADQVKMVGTVRSLHPEIRENLPSWIKGIVEGICNIYGAKCEIKYNHRLPSVQNDLNLTKIMEKAAMEALGEEQVINILEPSLGAEDFAVYLDYAPGTMFRLGIGMEDKKNYPLHHPRFELDESSIITGVITMAYSAYQYFHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z355</accession>
    <name>K9Z355_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ordered locus">Cyan10605_1478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219318.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1478"/>
    <dbReference type="EnsemblBacteria" id="AFZ53589">
        <property type="protein sequence ID" value="AFZ53589"/>
        <property type="gene ID" value="Cyan10605_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1478"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1568"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_2_0_3"/>
    <dbReference type="OMA" id="HWDISTI"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="626" mass="69689" checksum="8823A5759C7C886C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z369</accession>
    <name>K9Z369_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="7" type="ordered locus">Cyan10605_1488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219328.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1488"/>
    <dbReference type="EnsemblBacteria" id="AFZ53599">
        <property type="protein sequence ID" value="AFZ53599"/>
        <property type="gene ID" value="Cyan10605_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1488"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1580"/>
    <dbReference type="eggNOG" id="COG1165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006051_3_0_3"/>
    <dbReference type="OMA" id="FCNRGTS"/>
    <dbReference type="OrthoDB" id="897995at2"/>
    <dbReference type="UniPathway" id="UPA00995"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M_2" evidence="6">
        <location>
            <begin position="222"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="422"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="581" mass="66906" checksum="18C49255CFAD1A1F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z392</accession>
    <name>K9Z392_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0702"/>
    <dbReference type="EnsemblBacteria" id="AFZ52838">
        <property type="protein sequence ID" value="AFZ52838"/>
        <property type="gene ID" value="Cyan10605_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0702"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.735"/>
    <dbReference type="eggNOG" id="ENOG50318U5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108245_1_0_3"/>
    <dbReference type="OMA" id="WQNWRIF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021467">
        <property type="entry name" value="DUF3119"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35550">
        <property type="entry name" value="PTHR35550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11317">
        <property type="entry name" value="DUF3119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="14908" checksum="24D50FAB1AC31C3F" modified="2013-03-06" version="1">MNSTTLTSETIELTPRYNLPIFIIILGVALSLVQMFVGIITILFGFFLLIQANIIKLKFTPKALEVYRQQNKIREFPYTDWQNWAIFWQPVPILFYFKEVKSIHFLPIIFDPITLKKCLEKYYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A4</accession>
    <name>K9Z3A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0718"/>
    <dbReference type="REBASE" id="58409">
        <property type="entry name" value="Cap10605ORF717P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52853">
        <property type="protein sequence ID" value="AFZ52853"/>
        <property type="gene ID" value="Cyan10605_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0718"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.753"/>
    <dbReference type="eggNOG" id="ENOG502ZBWB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683647_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021107">
        <property type="entry name" value="Restrct_endonuc_II_HinP1I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11463">
        <property type="entry name" value="R-HINP1I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17782" checksum="AD63FD796F2C64FD" modified="2013-03-06" version="1">MDRAKIGSMTAKGGFINEQNICDKFNSWQKDNEAREWLFIMGYDSDKIKSFKVIHIPVKIYFFSENKVLIVNDILKGRGGLSAEWLLVTKKDKNANDKLDWILKDINTACNFFAQGDVKISPKGSLYIGKITMQRKGGTPDPTSLQFKINPLQLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D0</accession>
    <name>K9Z3D0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ordered locus">Cyan10605_0750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218614.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0750"/>
    <dbReference type="EnsemblBacteria" id="AFZ52883">
        <property type="protein sequence ID" value="AFZ52883"/>
        <property type="gene ID" value="Cyan10605_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0750"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.788"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_3"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="261"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="389" mass="42069" checksum="5C894D6E32E4F659" modified="2013-03-06" version="1">MKLITILGSTGSIGTQTLDIVRDHPDKFKVVGLAAGNNINLLAEQIREFKPEIVAIRDSNKLSELKDAITSVSPQPILLAGEEAICEVASYGEAQSVVTGIVGCAGLLPTIAAIKAKKDIALANKETLIAGGPVVLPLIEKYGVKLLPADSEHSAIFQCLQGVPEGGLRRIILTASGGAFRDLPVEKLASVTVQDALKHPNWSMGQKITIDSATLMNKGLEVIEAHFLFGLDYENIDIVIHPQSIIHSLIELEDTSVLAQLGWADMRLPLLYALSYPDRISTNWKALDLVQVGSLTFREPDHNKYPCMQLAYGAGKAGGCMPAILNAANEQAVALFLQEKITFLDIPRLIELVCDRFSSDNRPNPSLEDILHADSWARKAVLEQVSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G5</accession>
    <name>K9Z3G5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="5" type="ordered locus">Cyan10605_1006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218866.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1006"/>
    <dbReference type="EnsemblBacteria" id="AFZ53135">
        <property type="protein sequence ID" value="AFZ53135"/>
        <property type="gene ID" value="Cyan10605_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1006"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1064"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_3"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15258" checksum="8ECC3F5527300D3A" modified="2013-03-06" version="1">MVEKIKKTEQEWKEILTPEQFEVTRKHGTERAFTGEYHDFKGKGVYKCVCCGNELFVSDTKYNSGTGWPSFWQPIREDSVAYKNDFSLFMKRTEVLCNACDAHLGHVFNDGPEPTGKRYCMNSAALKFEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q8</accession>
    <name>K9Z3Q8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4351 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218926.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1071"/>
    <dbReference type="EnsemblBacteria" id="AFZ53195">
        <property type="protein sequence ID" value="AFZ53195"/>
        <property type="gene ID" value="Cyan10605_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1071"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1133"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069065_0_2_3"/>
    <dbReference type="OMA" id="PRANYKE"/>
    <dbReference type="OrthoDB" id="987684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022573">
        <property type="entry name" value="DUF2887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025587">
        <property type="entry name" value="DUF4351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11103">
        <property type="entry name" value="DUF2887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14261">
        <property type="entry name" value="DUF4351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4351" evidence="1">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="34483" checksum="39F3DD16D88F8382" modified="2013-03-06" version="1">MKTDKLFYQIFINQPSLINELLPEIPSNCQFEYTAPVVKDTEFRLDGLLTPLSDDKNIPLVFLEAQMQKDIKFYHRYFAEIFLYLSQYEIKRPWKGLLILKNKNNDLGSEVPYQILLNNNITRLYLEELSNIEKLSPNLALLRLIVSPNSEIKHLGNLVLSSAKTEEDFQRQFTLIEAILKSKLPQLKTEDILTMFDLKTATMPKLDAYETLVKYWQDKAKEEGIQKGLEEGIQKGLEEGEANLLIRQLNRRFGSLTENQKQKVRSLSIPQLESLAEDLFDFENISDFEKWLEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S5</accession>
    <name>K9Z3S5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ordered locus">Cyan10605_1679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219511.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1679"/>
    <dbReference type="EnsemblBacteria" id="AFZ53784">
        <property type="protein sequence ID" value="AFZ53784"/>
        <property type="gene ID" value="Cyan10605_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1679"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1782"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_1_0_3"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="33289" checksum="77A5421F13E3A409" modified="2013-03-06" version="1">MKIRRQQPSPPVAIETLRYQVKLPESEPQNILEKIVWQKEEEVARMREKVSLLELRKQVSQLNDAPLDFLSALKNSSRQPALIAEVKKASPSKGLIREDFDPEVIAKEYEKAGATCLSVLTDREFFQGSFDNLSIVRNAVKIPLLCKEFIIYPYQIYLARLQGADAVLLIAAILKDADINYFLKIINGLGMTALIEVHTLEECDRILNIEGVKLMGINNRNLQDFSVDLNTTKNILLARQDIIKEKQITVVSESGLYEKKDLDFVQSAGANAVLIGESLMRQENLVSAIENLYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T5</accession>
    <name>K9Z3T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218956.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53225">
        <property type="protein sequence ID" value="AFZ53225"/>
        <property type="gene ID" value="Cyan10605_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1103"/>
    <dbReference type="HOGENOM" id="CLU_2022884_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="14279" checksum="B611919F8CC903A4" modified="2013-03-06" version="1">MEIIYQILLKLSQFQVRVVGDHHGSLFMALIEIYIPINLTLISSKDKIEIPAIITFLMLISAIFFILFSIVVSSPQFWIALLQNSSKNWFKIILIQLWFVCLLFIWITALKYTIQRFLLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z465</accession>
    <name>K9Z465_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin propeptide, TIGR03798 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218899.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1042"/>
    <dbReference type="EnsemblBacteria" id="AFZ53168">
        <property type="protein sequence ID" value="AFZ53168"/>
        <property type="gene ID" value="Cyan10605_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1042"/>
    <dbReference type="eggNOG" id="ENOG50338GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168130_0_0_3"/>
    <dbReference type="OMA" id="EIWITTV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="12445" checksum="F2F0B688F991908D" modified="2013-03-06" version="1">MSQEAAIQFLEAVPENEELQQKLVAILESSENDREDAAQLANEYGYDITPDELWAEIQKRQQDLEARQEAGELTDEELEAVAGGEFVATAVVATVVGAAGLGWTIGGGIAPKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B6</accession>
    <name>K9Z4B6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53984">
        <property type="protein sequence ID" value="AFZ53984"/>
        <property type="gene ID" value="Cyan10605_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1885"/>
    <dbReference type="eggNOG" id="ENOG5033SAS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828243_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="41017" checksum="D3F1EE2A5B4E03E6" modified="2013-03-06" version="1">MSIELTIGRKADKPWWNRPLVGDKPLVDYLFKQYSRTHICPEIISLHDYHLEKLESVSVTLKALFNQKFTHSDFLIYARLEGYFQKYCQTKKHYFLVGKEFFKIILNNLDNLRSITKIEKKYNQPSLLAFYDSVYDLIKENHHKLIFQEKLIKLHYSFKCQFKETREIKIIDKYLAYFISISEVENLLYFLDLLRVNNLTNWDNFTRLSNFIEETKNGMIEDIKPFLLFAKSEGDFLIEIANKVIKIKEDDDTKLINIAKIFQYIALVDKYENLYSQFQLFLRCLSKWEKIYYDIVNIRKNYPIHQFIIPPSFKVKLPSFEIYKSYHDYLDYSCLTRLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C1</accession>
    <name>K9Z4C1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219714.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1890"/>
    <dbReference type="EnsemblBacteria" id="AFZ53989">
        <property type="protein sequence ID" value="AFZ53989"/>
        <property type="gene ID" value="Cyan10605_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1890"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2006"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_3"/>
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    <dbReference type="OrthoDB" id="116406at2"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="11">
        <location>
            <begin position="12"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="758" mass="85649" checksum="6BC5FD6F3FF274D1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G8</accession>
    <name>K9Z4G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219806.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1986"/>
    <dbReference type="EnsemblBacteria" id="AFZ54081">
        <property type="protein sequence ID" value="AFZ54081"/>
        <property type="gene ID" value="Cyan10605_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1986"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_5_2_3"/>
    <dbReference type="OrthoDB" id="2029116at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="16766" checksum="8E6653422BDBE2AC" modified="2013-03-06" version="1">MDYFIVELTNQKKIAIPLEQIQEVITVNYADICPIPGVKNSLLGLISQRGILLWLLDLSLLLQNIPSFSNRLSSSTILVTKLGRNNVGLIVKKLGEIKDFLQDKITQDNLGQSLPIPLLSEYVDSFIQDETELLPILNMNNIQIYLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H5</accession>
    <name>K9Z4H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisubunit sodium/proton antiporter, MrpC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1528"/>
    <dbReference type="EnsemblBacteria" id="AFZ53637">
        <property type="protein sequence ID" value="AFZ53637"/>
        <property type="gene ID" value="Cyan10605_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1528"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1623"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_2_3"/>
    <dbReference type="OMA" id="FFGIILK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12288" checksum="7F62F1B264A2895D" modified="2013-03-06" version="1">MIILEGFILATILCGFLGIMLKRNLVMKIMGMDVMSSGVIAYYVFIASRKGFFTPILTAKDNVDYADPVPQAVILTAIVIGFSIQALMLVGVMKLAVDNPTLETDEIENTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I8</accession>
    <name>K9Z4I8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219027.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1177"/>
    <dbReference type="EnsemblBacteria" id="AFZ53298">
        <property type="protein sequence ID" value="AFZ53298"/>
        <property type="gene ID" value="Cyan10605_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1177"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1243"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110687_2_0_3"/>
    <dbReference type="OMA" id="YWIANTT"/>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13543" checksum="0E50E63E0F884680" modified="2013-03-06" version="1">MSNNSLPVEILLTQYFKKNLTQLAKRYRSIRKDLEPLIECLKLGEILGEQISGSNYQVFKVRLKNSNIQKGKSADYRVIYYLKTSSKIILVTIYSKSDFSDISTKVIEQIIAEFENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I9</accession>
    <name>K9Z4I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219229.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1387"/>
    <dbReference type="EnsemblBacteria" id="AFZ53500">
        <property type="protein sequence ID" value="AFZ53500"/>
        <property type="gene ID" value="Cyan10605_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1387"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929743_0_0_3"/>
    <dbReference type="OrthoDB" id="2177498at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="34631" checksum="EF931483F20224CA" modified="2013-03-06" version="1">MEKINDLIDEMTERLEVMESKLELSSGSFSKINNGVTSLRQSIINLQENTKNTTVSLSEKMMRIQENLLTQTGVSHATLIKLNEQVKFIDNIADDLMVKIRLHSSAFQDDINNIEQKTDTLTDSLKDNINEWQSRIETLDNDLKNYLEETNNNLNSLQDISEKMRSQFREQREYLTNKSDSLQNLSKEKIAEIKNLILELFNSIEENLEKLKQVCKEENQQLNSWLNMKIKQGEFQDIIEEIKTLQNTSKKIESLTEESGEKIVISLEKNNDSLEEMNNKLSTAQQLYQSSLETIKSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K2</accession>
    <name>K9Z4K2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219389.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1553"/>
    <dbReference type="EnsemblBacteria" id="AFZ53662">
        <property type="protein sequence ID" value="AFZ53662"/>
        <property type="gene ID" value="Cyan10605_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1553"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1648"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_3"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="78"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="391"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="55279" checksum="841FE310F0DA5F43" modified="2013-03-06" version="1">MAKTRTVYICNCCGAESSQWFGKCPSCDTYGSLEEVILNSNGNFSRGGWQSNARPHQKNVTSPQPRISVKFSDIKEEEQPRMNSGYQELDRVLGGGIVPGSLVLIGGDPGIGKSTLLLQTANQLAIRFPRILYVSAEESGQQVKLRASRLGVGVIEEDEEDLNHNHNGNGHKGNQTNQDYSEPNLYVLAETDLEEILRELESLKPQVAIIDSIQTLHFATLNSAPGSVSQVRECTSALMQVAKREGITLFIVGHVTKEGAIAGPRVLEHLVDTVLYFEGDRYASHRLLRSVKNRFGATHEIGIFEMVDHGLDEVSNPSELFLSSRDELAPGTATIVSCEGTRCIVVELQALVSPTSYTSPRRSTTGVDYNRLQQILAVLEKRVGIPLSKLDAYVASAGGLGVEEPAADLGMAIAIVASFRDRTVDPRTVLIGEIGLGGQVRLVSQMELRLKEAAKLGFKRAIVPKGQTYPSDLGLEILCVGKVIDAIVLAIPNQSSSSVDINGDSIVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L7</accession>
    <name>K9Z4L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219851.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2037"/>
    <dbReference type="EnsemblBacteria" id="AFZ54126">
        <property type="protein sequence ID" value="AFZ54126"/>
        <property type="gene ID" value="Cyan10605_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2037"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2164"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_3"/>
    <dbReference type="OMA" id="QTGVYFQ"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="AMIN" evidence="10">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="228"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="404"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="867" mass="96478" checksum="6E9D541AEA6B4153" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P5</accession>
    <name>K9Z4P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219839.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2020"/>
    <dbReference type="EnsemblBacteria" id="AFZ54114">
        <property type="protein sequence ID" value="AFZ54114"/>
        <property type="gene ID" value="Cyan10605_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2020"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2146"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_18_15_3"/>
    <dbReference type="OMA" id="WKGLDYI"/>
    <dbReference type="OrthoDB" id="883339at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="30551" checksum="035D49B3295105A0" modified="2013-03-06" version="1">MFIQIQEKIKQVKEKKLKVLDLSYDCDREEQKLEKIPPEIFDLKQLEYLSLRGHSLKKIPQEINNLINLQYLDLSSNQLDEIPSEMGSLISLEHLDLSRNQLFCLPTTFVNLNSLIYLDLSINQFSEFPEFLGEIASLKYLSFAVNRLYSLPESIIKLSNLNHLDLSKNKFVRFPEFITSLKKLTYLDLSVNQLTSLPENIDQLSELRDLGLLNNQIKTLPTSMINMTNLEYMELWDNPLPKNLSREIGFEDIRKYFDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S2</accession>
    <name>K9Z4S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219444.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1609"/>
    <dbReference type="EnsemblBacteria" id="AFZ53717">
        <property type="protein sequence ID" value="AFZ53717"/>
        <property type="gene ID" value="Cyan10605_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1609"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1710"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043242_0_0_3"/>
    <dbReference type="OMA" id="NWFLWGL"/>
    <dbReference type="OrthoDB" id="1217682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="494" mass="55217" checksum="36AC6F22CAB1F979" modified="2013-03-06" version="1" precursor="true">MNVKRSLLIILTAISLYSVFFALTQSLTETQIQSRLELYQTNLILNASEWQPSSDNQKSFTQNLLGNNPYLIAQEQYNNILTEAESVKGSEKISNQEDKAIASETPRKQLKQEIQENQAFIEDLKIKLGIIYAYQENNDKAIAYWQEINDKSTAEILNSIWINNSDISVNKQEIIEKKLNGWFENITLSKLYAIENNLNKLEEINNKTQELAEKAIKRLLLLSVIPVVGGLIGFGLIIFLIVQLALKKEESILATNAGKTWDSPWDWEIIGQVLIVGFFFLSQILLPILIGVSGFNPTDLDIKGKALYVLVTYLLMAGGGLSVLYLSIKSFFPLPTDWFKLTNKNWFWWGLGGYLTAIPLVFFVSLLNQQIWQGKGGSNPLLMLALESQDKFALIIFFITASIAAPIFEEIIFRGFLLPSLTRYMSVGSAIVVSGIIFAIAHLSLAEALPLAVLGIILGIVYTRSGCLLASIMVHSLWNSGTLFSLFLLGSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z553</accession>
    <name>K9Z553_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219994.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2183"/>
    <dbReference type="EnsemblBacteria" id="AFZ54269">
        <property type="protein sequence ID" value="AFZ54269"/>
        <property type="gene ID" value="Cyan10605_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2183"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2319"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039510_0_0_3"/>
    <dbReference type="OMA" id="TVAWAQG"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019896">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase_CsaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03609">
        <property type="entry name" value="S_layer_CsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="346" mass="38828" checksum="7006D930A61173F1" modified="2013-03-06" version="1">MRKAIICGYYGQGNAGDEALLLAILSRLNNNITPIILSGNPQKTNQDYGVISYSRFQIIKEILKLTKKDLFIWGGGSLIQDITSVKSAIYYLTLMALAQLKGVKTIAYAQGIGPIKTPLIQWLTKIVLKRCDRISVRDQKSAKLLDKWGIKCLIAPDPVWALPSKITKKIELLPAPRIAVNLRSHSSLTITKIETISQVLIKIKEKINANIILIPFQISKDLEVCEKIAQQLKTNYQILTLENAQELKGLFSQIDMLIGMRLHSLIMAGSENCKCFALSYDPKVSNLMREINIKGYDLEKLPTNIDEIVQECLNTYNNPNPISPHQIQKLAEDALKHHQLIDSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z562</accession>
    <name>K9Z562_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220004.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2193"/>
    <dbReference type="EnsemblBacteria" id="AFZ54279">
        <property type="protein sequence ID" value="AFZ54279"/>
        <property type="gene ID" value="Cyan10605_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2193"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2330"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026771_1_1_3"/>
    <dbReference type="OMA" id="FRFVDVM"/>
    <dbReference type="OrthoDB" id="402265at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="495" mass="57962" checksum="D234EF7F72439A5E" modified="2013-03-06" version="1">MSQEKLIQRMQQANFYHHPVKEPIKIIQTHCSIVFLTGNYAYKMKKIVDFGFLDYSTLAKRQHFLSVELEMNKQIAPDLYLEVLPIYEENNNFYWQEQGQIKEYVLKMNQFPQENLLLNIYQQGNLTSQHMKELGKLVAKFHQNTVTNEYITSFGTPEKIGESISQNYEQTQKYIGIAQNQEQYEQTKTFTDIFLHNYRDVLEKRQTDHKIKECHGDLHLKNICIWQDKIQLFDRIEFNEPFRFVDVMYDVAFTVMDLDSKGEKTLANVFLNTYLEETGDWEGVLVLPLYLSRQAYVRAKVTSLLLDDRAISEEEKVKAKETAAAYYHLAWQYTQPSQGKIIMMSGLSGSGKTTIATKKARELNAIHIRTDAVRKHLANIPLQEKGEKEIYSQAMTAKTYQKLLDLAKILTIQGFKVILDGKFDRICWRHPVLEFALNHNIEFEIIYCHAPLDVLQNRLRQRNSDISDATPELLKQQQKQQEAFTEKEKLFLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D1</accession>
    <name>K9Z5D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, cation-chloride cotransporter (CCC) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220073.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2264"/>
    <dbReference type="EnsemblBacteria" id="AFZ54349">
        <property type="protein sequence ID" value="AFZ54349"/>
        <property type="gene ID" value="Cyan10605_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2264"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2404"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001883_3_1_3"/>
    <dbReference type="OMA" id="KNWRPHI"/>
    <dbReference type="OrthoDB" id="175418at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015377">
        <property type="term" value="F:cation:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="PTHR11827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="17"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12" evidence="7">
        <location>
            <begin position="468"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="737" mass="81443" checksum="BF05D2C94A99B849" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D5</accession>
    <name>K9Z5D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KGK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2312"/>
    <dbReference type="EnsemblBacteria" id="AFZ54396">
        <property type="protein sequence ID" value="AFZ54396"/>
        <property type="gene ID" value="Cyan10605_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2312"/>
    <dbReference type="eggNOG" id="ENOG5033KVV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136180_1_0_3"/>
    <dbReference type="OMA" id="EAKEWCN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014971">
        <property type="entry name" value="KGK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08872">
        <property type="entry name" value="KGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11675" checksum="8C94D64874DB9C2A" modified="2013-03-06" version="1">MDQKIEHLEKNDVIQMKKDKSRWVMKQTTFTVNDFISTLSNCYISDAEAKEWCNNGVEAEVLVPRKPWRKGKIRLSIEFIPDESEIESPLDDFRQKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D9</accession>
    <name>K9Z5D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S1P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220125.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2317"/>
    <dbReference type="EnsemblBacteria" id="AFZ54401">
        <property type="protein sequence ID" value="AFZ54401"/>
        <property type="gene ID" value="Cyan10605_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2317"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2462"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_0_1_3"/>
    <dbReference type="OMA" id="YDYHFSP"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="346" mass="38590" checksum="64E0BAA29A46966C" modified="2013-03-06" version="1">MVNQTETLNSNVSFTHEEFAALLDQYDYHFSPGDVVPGTVFSIEPKGALIDIGAKTAAYIPVQELSINRVDDPSEVLQANETREFFILTDENEDGQLTLSIRRIEYMRAWQRVRQLQEEDATVYSNVFATNRGGALVRVEGLRGFIPGSHISAKDTKEDLVGQDLPLKFLEVDEERNRLVLSHRRALVERKMNGLEVGQVVIGSVRGIKPYGAFIDIGGVSGLLHISEISHDHIDTPHSVFNVNDELKVMIIDLDAERGRISLSTKQLEPEPGDMLKNRELVFEKAEEMAQKYKEKLLAGDAEEANVDSDSVQEVAEGEEVTATETTETSDIENQSEEELTTTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E1</accession>
    <name>K9Z5E1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">Cyan10605_2274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220083.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2274"/>
    <dbReference type="EnsemblBacteria" id="AFZ54359">
        <property type="protein sequence ID" value="AFZ54359"/>
        <property type="gene ID" value="Cyan10605_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2274"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2415"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_0_3"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="88"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="308" mass="35015" checksum="12EAA23EE6A74263" modified="2013-03-06" version="1">MFGSGFPDNLSSFIVFFRQFLDLGFAVFSFYYISVLIRERRAQRMIRGLFFLFIIFYVSDRIFQLKLFSFFLERLILICSLSLALVFQSDFRRFLEQIGRWQFDFSSSNSSLPKEDSAIDEMVEAVKDLSQNRVGALIIVETFNTLEERIFVNPGVQLNAIVSKELLQTIFQTKSLLHDGAVFVRGNEVVSAGVILPLSDRSASRQLGTRHRAAMGITERVDNCICIVVSEETGSISLAEKGTLNRPLTSTKLKELLEEKLSQPSEGEVVTGVSRLSKKLSFGGRKFLANLFKFGKKKKLLEQQKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F3</accession>
    <name>K9Z5F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219699.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1872"/>
    <dbReference type="EnsemblBacteria" id="AFZ53972">
        <property type="protein sequence ID" value="AFZ53972"/>
        <property type="gene ID" value="Cyan10605_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1872"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1987"/>
    <dbReference type="eggNOG" id="ENOG502ZC6B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125421_0_0_3"/>
    <dbReference type="OMA" id="LTDVSWH"/>
    <dbReference type="OrthoDB" id="1420384at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17900" checksum="76C211FDB04DEAEA" modified="2013-03-06" version="1">MILNFSFKLLTEGGKLLCKCSLYKTYRVASSVPVDMVWGKLINLADMSWHPLFSQTNLPKGLIPKPGLIFSVVTRLTPFPIRAFVESVRPRELLSIRLLAIPGIEQRITYQIESTLCGSYIAYSITLRGWLSPFIWWLIKPYSIKVANELVNAAAKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N3</accession>
    <name>K9Z5N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chlorophyll synthase</fullName>
            <ecNumber evidence="7">2.5.1.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.62" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219607.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1778"/>
    <dbReference type="EnsemblBacteria" id="AFZ53880">
        <property type="protein sequence ID" value="AFZ53880"/>
        <property type="gene ID" value="Cyan10605_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1778"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1887"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042598_0_0_3"/>
    <dbReference type="OMA" id="QDMYFLR"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046408">
        <property type="term" value="F:chlorophyll synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13958">
        <property type="entry name" value="PT_UbiA_chlorophyll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006372">
        <property type="entry name" value="Chl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011799">
        <property type="entry name" value="ChlG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02056">
        <property type="entry name" value="ChlG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01476">
        <property type="entry name" value="chlor_syn_BchG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="36462" checksum="45E5B71608B31D9A" modified="2013-03-06" version="1">MTNTEDKDYTKVELDREDKGSKARQLLGMKGASQAKSIWQIRLQLMKPITWIPLIWGVVCGAASSGGYVWGFEDFMMALTCMLMSGPLLAGYTQTINDFYDRDIDAINEPYRPIPSGAISVPQVVAQILILLFAGIGVAYGLDVWAGHEFPILTCLAIGGSFISYIYSAPPLKLKQNGWLGNYALGSSYIALPWWAGHALFGELNWTVVILTLVYSMAGLGIAVVNDFKSVEGDRTLGLKSLPVMFGVTTAAWICVIMIDVFQIAMGGYLIYLGQNLYATILLLLVIPQITFQDMYFLRDPLKNDVKYQASAQPFLVLGMLVMGLALGHSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S4</accession>
    <name>K9Z5S4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-vinyl reductase 4VR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219817.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1998"/>
    <dbReference type="EnsemblBacteria" id="AFZ54092">
        <property type="protein sequence ID" value="AFZ54092"/>
        <property type="gene ID" value="Cyan10605_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1998"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2121"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106284_0_0_3"/>
    <dbReference type="OMA" id="VLEAWWW"/>
    <dbReference type="OrthoDB" id="1171270at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="238" mass="27732" checksum="DAC4BFB9E6A37A19" modified="2013-03-06" version="1">MTFTPTKSDRIVEKISKNLWKSKYPKKHDHYTLEDFFHFDTNRGDITDWNESRNVLVTEDFIVGLIEGLEEEVGSASSVVMYNIGKAWGVRDAEFFEKWFQEEYEYPKNIHDMNLLYVLEAWWWPFTTQGWGNWDVDLSEQKNGFMFVNIFDSAVARTLGDVGKPVCHIYAGLMAGFFSRFINKPLNCIEIQCYSMGETYCKFLLGKQDRIDAATFWQNEGAGAKDIQKKLVNGEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z652</accession>
    <name>K9Z652_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative site-specific DNA-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2108"/>
    <dbReference type="REBASE" id="58402">
        <property type="entry name" value="Cap10605ORF2107P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54197">
        <property type="protein sequence ID" value="AFZ54197"/>
        <property type="gene ID" value="Cyan10605_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2108"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2241"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136571_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="28090" checksum="DF75EA2D0D6163D0" modified="2013-03-06" version="1">MLIKSNHSTLSMNYKELLISIYQEVIEGKSYSSKINNGTLKNIEIIAKKCFSQKGVYTVLVTLIIYKILHPEQDIRNHQAQIEGGFSGRVIDTQYISPTLRELGLPAMAESGWTTRSLEQPYPYTLDYQGRIGNKQVKKAFLELLDTIQNQKINPKYILHELLTQIIVIQQLNKVVIQPLNNAEKLTINKIIKVLDSQFSFNYKIFGGSKLPVLAFYSLYDDLELKSVHKQKWIELLKELENDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A5</accession>
    <name>K9Z6A5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219992.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2181"/>
    <dbReference type="EnsemblBacteria" id="AFZ54267">
        <property type="protein sequence ID" value="AFZ54267"/>
        <property type="gene ID" value="Cyan10605_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2181"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2317"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_3"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="431" mass="46826" checksum="95A5D5A56EDF3486" modified="2013-03-06" version="1">MSAEIICIGTELLLGDILNSNSQFLAQELAILGIPHYFQTVVGDNLARIHEVINIASQRSSILIFTGGLGPTPDDLTTEAIASFFQGTLEEKSEIIEDIEVKFAQRGRKMTNNNRKQALLPKGADILPNLTGTAPGMIWQPFLNNVNHPQQKLTILTFPGVPSEMKQMWRDTAVPFLQSQGWGKEIIVSEMMRFRGIGESALAEKVNHLFALTNPTVAPYASHGEVKLRVSTKAKNEAEARKIINPIVEEIKAIALEDYYGSDEDTLEGVVGKLLTARGETVSVAESCTGGGLGAMFTACGGSSAYFYGGIIAYSNQVKIRQLGVSEADIEQFGAVSETVAQQMAKGVKNRLQTDWGIGITGIAGPDGGTETKPVGLVYVAIAQPHFVTASPSSDTISYELKWGINRDRQTIRYLTCCFALDQLRRKLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F6</accession>
    <name>K9Z6F6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220489.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2693"/>
    <dbReference type="EnsemblBacteria" id="AFZ54766">
        <property type="protein sequence ID" value="AFZ54766"/>
        <property type="gene ID" value="Cyan10605_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2693"/>
    <dbReference type="HOGENOM" id="CLU_1394304_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22777" checksum="AAB7071BBA9841A7" modified="2013-03-06" version="1">MAWFDFQTTIYELNPSKQITAEDVNNKLISLEEKWQQEALSTKSINFPLLRSSLTRIYQDLGYDLPQFIYFSSPCQLGQYVCQSVINSFSQEDLQLLTCKILFHLQGKEKGLLREITKEIIIVFHHYFDLWFGANFKGKFKSNFETNKNLKIADIDLNLKVAIEKRRSHLGKRYVGLTGESIQMILLWLVSIKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F8</accession>
    <name>K9Z6F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219885.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2071"/>
    <dbReference type="EnsemblBacteria" id="AFZ54160">
        <property type="protein sequence ID" value="AFZ54160"/>
        <property type="gene ID" value="Cyan10605_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2071"/>
    <dbReference type="eggNOG" id="ENOG5030BDP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054352_0_0_3"/>
    <dbReference type="OMA" id="GIGGEFY"/>
    <dbReference type="OrthoDB" id="583634at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="422" mass="50258" checksum="2297F8546AA47CD6" modified="2013-03-06" version="1">MDNLSIEQCYKILNIDNDLTLAEIDKHYYSLVAEKLKSGEKEELVSIRQAYLQLTEYKQKEQKNKEKTQTKQFDIYLTKTLNKELLYLGVRIKVESYPDHILLKFRNLTKIKKSQIVKLVYDYLTKLIKEETKIVLINFGHKNQIIWQTEFKILPNISPDKLANYNQDIFLAEAEIKTNTYALPIAFFIAFAINFIDPLVWFISVWIHELGHATLAWFSGYRAMVTFAATIVSFEHSLFVYFGILFLLLLTIYSTWKENKKYIIIFLVFLIFLQFILTWTISRSTYGMLLAFAGIGGEFYLSTLFIISFYWNLPQRFYWEFWRYIFLIWGMITFWGSWTRWQKIKVGKSQIPWGTFWSGRGDSGGDLNILRNQHDWGIERIINTYNTLGFICFLVILFVYFYNLWISNPNLRLRVNKMFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G4</accession>
    <name>K9Z6G4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219890.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2076"/>
    <dbReference type="EnsemblBacteria" id="AFZ54165">
        <property type="protein sequence ID" value="AFZ54165"/>
        <property type="gene ID" value="Cyan10605_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2076"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2206"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102912_1_0_3"/>
    <dbReference type="OMA" id="GCFPFFG"/>
    <dbReference type="OrthoDB" id="1672574at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="186" mass="22072" checksum="B391705B92856870" modified="2013-03-06" version="1">MNFVHKNKTSNVKQKLTKNCYYSKTKKLNKKQFRKKDYPWKRYGKYYKWKLLRLREHPHKIARGFAVGVFSGCLPLMGLQFLISLLLAFIVRGNKFTALMGTWISNPFTYVPLFIFNFHVGKIILGFFISNQDLQFNWQSWREFAQMGTEITVTLLFGSVIVGIVFATIAYHFILRLLYHWKKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I1</accession>
    <name>K9Z6I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220519.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2724"/>
    <dbReference type="EnsemblBacteria" id="AFZ54796">
        <property type="protein sequence ID" value="AFZ54796"/>
        <property type="gene ID" value="Cyan10605_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2724"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2890"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_3"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="43103" checksum="26B0A850A8DF8294" modified="2013-03-06" version="1" precursor="true">MKLNDALKMAMTTIFANKMRSSLTMLGIVIGNASVIAMIGIGEAAQRLASEQFETLGANVLFVVPGSRESRRTTFEVPKTLVLDDANAIASQVPTVEEVAPQINSRLLVTYRNRNNNVSIIGTTPEFLTVRSFDVAQGRFINDSDLKRNNRVAVLGSQIAEEFFPNENPIGKRLRVKNVSFEVIGIMEAKGSFLGTNQDETVYLPLTTMANQIVGKTSNYGLELSFISVSANSSDSIAAARFQIENLLRLRHKINGEDDFRVETQKDILSIVGTVTSGLTMMLGAIAAISLLVGGIGVMNIMLVSVSERTQEIGLRKAVGATENNILSQFLIEAIIISAIGGLIGTVIGVSGLIVIGLVSPLPTAISANTIILAVGVSGGIGLFFGVIPAQQAAKLDPIVALRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L8</accession>
    <name>K9Z6L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220502.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2706"/>
    <dbReference type="EnsemblBacteria" id="AFZ54779">
        <property type="protein sequence ID" value="AFZ54779"/>
        <property type="gene ID" value="Cyan10605_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2706"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2871"/>
    <dbReference type="eggNOG" id="COG4241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080696_0_0_3"/>
    <dbReference type="OMA" id="ENLWVVI"/>
    <dbReference type="OrthoDB" id="1112122at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28416" checksum="F437BB5577ABB09A" modified="2013-03-06" version="1">MTDSKPDFSVDDSNWIDEEETYQSIASESDANLKDKQTKYYQFKPETIALVESAFLASTASLIWLIDYYFRIGPFLKMLFPLPIALVYLRRGKRASIITTIVCGLLLAILMGPPRSIVYIVPYGLMGIQLGALWRRGVNWYVSIFVASLIGCFGFFFRFWLFSILLGEDLWVYVISQITNLADWIFLKLGILARPDMITIQLLAIAVVMVNNIIYSLTVHLVALLMLDRLKTPIPRPPKWLQVILDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P8</accession>
    <name>K9Z6P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220532.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2737"/>
    <dbReference type="EnsemblBacteria" id="AFZ54809">
        <property type="protein sequence ID" value="AFZ54809"/>
        <property type="gene ID" value="Cyan10605_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2737"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_0_1_3"/>
    <dbReference type="OMA" id="QTETYAC"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="32742" checksum="87E15911AE677B26" modified="2013-03-06" version="1" precursor="true">MSVKLSKLLLSFALFCWFGGGYLTPSIAKGETVLEKINRTGVLRVGVRNDAIPFGYRDNGRLEGLCLSLIQLIREEIIRTEQRNIISIDLLVSGLYNRFDIVQDKVVDLECGPNSIRSIPEYSRVTFSEPFFISGLQLITRRDRTSSVLNSDGKDLTIGVLAYTNTENLIKEKYPLAQLEFFQGAKGNLRGIQSVNQERIDAFANDGILLLGEAILNRIPIEDNSPLSIVPEIPLTCERYGLILPKDENWENLVNSVLQSEDFRRIRRDWFISLAKESLIPSQQCVDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q7</accession>
    <name>K9Z6Q7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219808.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1988"/>
    <dbReference type="EnsemblBacteria" id="AFZ54083">
        <property type="protein sequence ID" value="AFZ54083"/>
        <property type="gene ID" value="Cyan10605_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1988"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2109"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_3"/>
    <dbReference type="OMA" id="MKGEARM"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="806"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="857"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="927" mass="104929" checksum="D7C47F1D66AC4E88" modified="2013-03-06" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFZ54245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="11106" checksum="E099D13971CE0ADA" modified="2013-03-06" version="1">MLLIKIIDLTLGKTQNFTLIKDSSFYFESKGEYEIMSNSVGLSLEQQFNLRSFETQVEKMTKEQAQDFLVKLYAEMLVRENLYKDTLKHQWGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFZ54260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="613" mass="64782" checksum="45E32497AC8AF819" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
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    <name>K9Z6X5_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="546" mass="61915" checksum="C146CCDC2010B57A" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z711</accession>
    <name>K9Z711_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Cyan10605_2863</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="gene ID" value="Cyan10605_2863"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="397" mass="46754" checksum="2F739597BB44DE83" modified="2013-03-06" version="1">MLLNNLTKKFKHWLPLAKSKIEKGASQLENSINNYDPKEIIPSKLIERLNTKLNSLPVYESYYDTLTINVHDYIHQWIINKEQNRKNCLVIKGNCVDNLYNILTSIFSEKSSLSKETIELDYQIFSLENLKQNRRDRLNYLQEKILEIQQQSDKKIILIPDLSYYFSRTIEGLEVLEKLLKLLDEDENKFWIIGCNHWLWLFLVKIYHWDAYIENARDLPLLSQENLQDILLPVLDLVEFDWNDLRRFLVELPNQNEDDHKIISQLQAKYFENLANLSQGCLGTASQLCFYSLRYVKNEETELSNLKINNPQLPDFPSITQSDRYLLFCIGLHGHLNKSDLANILGDDQIYITSQIECLVNLNLIHFLDHQNIAINPLFYSKLTKDLKDNHFLVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z724</accession>
    <name>K9Z724_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
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                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AFZ54173"/>
        <property type="gene ID" value="Cyan10605_2084"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2215"/>
    <dbReference type="eggNOG" id="ENOG5032S9I">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1855046at2"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="DUF3007"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11460">
        <property type="entry name" value="DUF3007"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="7"/>
            <end position="24"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="11225" checksum="9E6A02A82E7F2C43" modified="2013-03-06" version="1">MRRIDAILIAFAVFVAGGIIYIIFQYLGFDAYDAGIWSQVLLVLGLIGWVVTYLFRVFTNNMTYHKQVKDYDDAFFAKQLEKMSPEEIEKLMAEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z740</accession>
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        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2902"/>
    <dbReference type="EnsemblBacteria" id="AFZ54964">
        <property type="protein sequence ID" value="AFZ54964"/>
        <property type="gene ID" value="Cyan10605_2902"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2902"/>
    <dbReference type="HOGENOM" id="CLU_3355709_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="36" mass="4392" checksum="C42CF45F75DCDE73" modified="2013-03-06" version="1">MTLPREQPKAKELNFKQKCFGLMSYSQFFMLIMYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z758</accession>
    <name>K9Z758_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulphatase-modifying factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2976"/>
    <dbReference type="EnsemblBacteria" id="AFZ55036">
        <property type="protein sequence ID" value="AFZ55036"/>
        <property type="gene ID" value="Cyan10605_2976"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2976"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="DMTFGMG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="33206" checksum="129B238561007842" modified="2013-03-06" version="1">MDNLKKNQIEVVTIDTNQNQYQDYPTLTLRKQTKEIEYFSVNLDEKVTLDMVSIHGGKFKMGTPTQEQGRSKDETPEHEVEIKDFFVSKYLITQSQYQAIMKENPSFFAGDNKPVENISWFDAHNFCQQLSQLTGIKYRLLSEAEWEYICRAETTTSFCYGTTITSELANYKASFGYGLGGSGKWRQETTEVGIFPANNYGLYDVHGNVWEWCEDHWHENYIEAPTNGQPWLEKETSLDSEEEIPRVIRGGSWDDTAYYCRSGVRLWALPSFKGKLIGFRIACDSMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B2</accession>
    <name>K9Z7B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3027</name>
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    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55086">
        <property type="protein sequence ID" value="AFZ55086"/>
        <property type="gene ID" value="Cyan10605_3027"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3027"/>
    <dbReference type="HOGENOM" id="CLU_3308340_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="39" mass="4548" checksum="D4390832D2898B23" modified="2013-03-06" version="1">MKQDLQQLYFNSEELKQLTGISIDLNKITPRSETSLCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C0</accession>
    <name>K9Z7C0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="Cyan10605_2182"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2318"/>
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    <dbReference type="OrthoDB" id="2060174at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="164" mass="18934" checksum="E8D859C6ED6472B6" modified="2013-03-06" version="1" precursor="true">MKIRHNKFLNFNSIIFLSVFVGLNTLLNSFLVQVKADSSHQHGMNMSSENGHAHKTLDVSNLNEIPSIEIEIFPDKIKGWNLYLNTKNFEFISPNLENNNPNQGHAHLYINGVKVSRIYSNWYYISELPEKDNEIEITLNTNNHHDLIYNGKIVGDRILITNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C9</accession>
    <name>K9Z7C9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ordered locus">Cyan10605_2989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220768.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2989"/>
    <dbReference type="EnsemblBacteria" id="AFZ55049">
        <property type="protein sequence ID" value="AFZ55049"/>
        <property type="gene ID" value="Cyan10605_2989"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2989"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3183"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_3"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="18750" checksum="ED395C4439E53361" modified="2013-03-06" version="1">MEELENHQYWMSQALIMAKEAGNRGDIPVGAIVVDNYNNLIAKASNQKELQKSAIAHAEILAINQANQKLGKWRLDNCTLYVTLEPCPMCIGAIIQARIKTLVYGVDDFKTGAVRTILNIPDSEVSNHRLQVFAGIQAVACGDLLKSWFNQLRQGKRQGAMEKLRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G6</accession>
    <name>K9Z7G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220855.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3079"/>
    <dbReference type="EnsemblBacteria" id="AFZ55136">
        <property type="protein sequence ID" value="AFZ55136"/>
        <property type="gene ID" value="Cyan10605_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3079"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3282"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_0_3"/>
    <dbReference type="OMA" id="LCIFWRA"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="29857" checksum="DDE24BC33AFB6537" modified="2013-03-06" version="1">MITNFFSALQLEFMQNAIMAGFLVSIACGIIGTFVVVNRIVFISGGIAHSAYGGIGLGYFFGFNPIIGAIAFSLLSGFGMAIVERNTGERKDTIIGTMWAMGMSIGIIFIDLTKGYKANLMSYLFGSILAVPKQDLWIMLILDLVIITMVCLFYKELLAISFDPMFATTRNLPVNSLYLMLVGAIALTIVMVMQVVGLIMIIALLTIPAAVANQYVQEMKQMMILSSILGVIFILLGLSLSFVFNLTSGATIIMVAGCVYFLSLIIKQWQLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M3</accession>
    <name>K9Z7M3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkA-C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220308.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2504"/>
    <dbReference type="EnsemblBacteria" id="AFZ54585">
        <property type="protein sequence ID" value="AFZ54585"/>
        <property type="gene ID" value="Cyan10605_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2504"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2654"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_1_3"/>
    <dbReference type="OMA" id="IHWQSLV"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="602" mass="65961" checksum="C72F3EE97A3283E5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M6</accession>
    <name>K9Z7M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3101"/>
    <dbReference type="EnsemblBacteria" id="AFZ55154">
        <property type="protein sequence ID" value="AFZ55154"/>
        <property type="gene ID" value="Cyan10605_3101"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3101"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3305"/>
    <dbReference type="eggNOG" id="COG4446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105603_1_0_3"/>
    <dbReference type="OMA" id="GDKPNCV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010865">
        <property type="entry name" value="DUF1499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07386">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026426">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15840" checksum="BC66D3C2603397EF" modified="2013-03-06" version="1">MASIFHFEGSVPTDLGVTDGKLKQCPPSPNCVVSQTEDETHYIKPLKYNSDRTSAYNNFLKILSVVPDTVIVEKTDDYIRTESRSKIMGFVDDAEFYFPEDEKVVQWRSASRLGESDLGVNRRRLEQIRLAFSDLTVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q9</accession>
    <name>K9Z7Q9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ordered locus">Cyan10605_3160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220929.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3160"/>
    <dbReference type="EnsemblBacteria" id="AFZ55211">
        <property type="protein sequence ID" value="AFZ55211"/>
        <property type="gene ID" value="Cyan10605_3160"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3160"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3367"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_0_3"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="20595" checksum="D64888814A43FB14" modified="2013-03-06" version="1">MSITLECKTRAEGGNPRALRREGFIPANLYGHKGAESVSLVLTQKEALTLLKNASVNNTLVELNVPEINWNGQVLIREVQTHPWKRNLHHISFFCPSADKDVIVVVPLKIVGHSIGISKGGIMEQMVTEVKVRCLPDKIPQFLEMDISHVDIGKTFSVGNLVLPEGITVLDDPHKNIIGIVAPRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z847</accession>
    <name>K9Z847_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220629.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2840"/>
    <dbReference type="EnsemblBacteria" id="AFZ54907">
        <property type="protein sequence ID" value="AFZ54907"/>
        <property type="gene ID" value="Cyan10605_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2840"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3018"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="242" mass="27216" checksum="559148D1DD3329AA" modified="2013-03-06" version="1">MELFLQNIHKYYNKRCIVNRVNLKVSQGEIVGLLGPNGAGKTTTFYITTGLIKPNEGNVYLDQEDITKLQLNKRAKLGIGYLTQQASIFRNLTVKENIQLVLEQTNNSPRFQQMRLEQLIAEFRLEKIVNTKGSQVSGGERRRTELARALAVGKEGPKFLLLDEPFAGVDPIAVSEIQEMIAKLKNNGMGILITDHNVRETLAITGRSYIMREGQILASGTGEELYNNPLVRQYYLGDNFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z869</accession>
    <name>K9Z869_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ordered locus">Cyan10605_2861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220649.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2861"/>
    <dbReference type="EnsemblBacteria" id="AFZ54927">
        <property type="protein sequence ID" value="AFZ54927"/>
        <property type="gene ID" value="Cyan10605_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2861"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3041"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_3"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="24834" checksum="00A77F735D2753AA" modified="2013-03-06" version="1">MTTTDPVVIMKQEVGKAAADRVQSNSIVGLGTGSTTAYAIQYIGERLQKGELTNIVGVPTSFQAEVLAKKYGIPLTTLDAVTHIDVAIDGADEVDPHKNLIKGGGAAHTREKVVDSLANQFIVVVDSGKLVDKLGSTFLLPVEVIPMAVTPVMNKLEQLGGKPELRMGIKKAGPVVTDQGNLVIDVKFESIDNPAELEKTINNMPGVLENGLFVGVADVILVGEIIDGKPSVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H4</accession>
    <name>K9Z8H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220746.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2965"/>
    <dbReference type="EnsemblBacteria" id="AFZ55027">
        <property type="protein sequence ID" value="AFZ55027"/>
        <property type="gene ID" value="Cyan10605_2965"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2965"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371619_0_0_3"/>
    <dbReference type="OMA" id="IIQEFMV"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="691"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="759" mass="87712" checksum="135523B3ABF4D17F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I0</accession>
    <name>K9Z8I0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221219.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3464"/>
    <dbReference type="EnsemblBacteria" id="AFZ55501">
        <property type="protein sequence ID" value="AFZ55501"/>
        <property type="gene ID" value="Cyan10605_3464"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3464"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3689"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141654_0_0_3"/>
    <dbReference type="OMA" id="VECHIIT"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="265" mass="31302" checksum="38536455F6A3547C" modified="2013-03-06" version="1">MRLVQRHIIRPDHKYYQYFDQQCYLSKNLYNLSTYRYRQHFFQTGQKLSFNDLYHQVSKTSAYYALPNTKVAKQIIRRIDQSWKGYFQAHKDWSRVDNYLHTVSRRVIDWCLLNSIGTLVIGKNDHWKQSINIGKKNNQQFVSIPHARLIEMLCYKGELMGIKVVVTEESYTSQSSFLDFDTLPSYGEKKPKFSGKRIKRGLYKTSTGKLINADVNGSYNCIRKHLQQEKVKSNAFHSHDLMALPFMPVTYDPLRTHNLNFLQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K0</accession>
    <name>K9Z8K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221207.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55489">
        <property type="protein sequence ID" value="AFZ55489"/>
        <property type="gene ID" value="Cyan10605_3449"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3449"/>
    <dbReference type="eggNOG" id="ENOG50346H4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2179470_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12818" checksum="9A0B7DBDCD39B588" modified="2013-03-06" version="1">MTYPTWYQEAIARGIDFIVIVYEKAEGFVFCPSNLETTFRVGGDYDGSFYTNGEGALRHYYNCLNPAFEEKIAWFIPFVNKIVNKEDFSLDDLELNHHPIRIIKGRWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N8</accession>
    <name>K9Z8N8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3528"/>
    <dbReference type="EnsemblBacteria" id="AFZ55561">
        <property type="protein sequence ID" value="AFZ55561"/>
        <property type="gene ID" value="Cyan10605_3528"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3528"/>
    <dbReference type="eggNOG" id="ENOG502ZB6U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465990_0_0_3"/>
    <dbReference type="OMA" id="VEYHILE"/>
    <dbReference type="OrthoDB" id="252419at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="585" mass="66504" checksum="10FA261888883258" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P2</accession>
    <name>K9Z8P2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220816.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3040"/>
    <dbReference type="EnsemblBacteria" id="AFZ55097">
        <property type="protein sequence ID" value="AFZ55097"/>
        <property type="gene ID" value="Cyan10605_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3040"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3236"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_3"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="6"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="42286" checksum="E3CD9582CB0B9343" modified="2013-03-06" version="1">MRDRPIYLDGHATTQVDERVIKAMMPYFTEYFGNPSSNAHVYGWEAQAGVKKARDAIASAINAEPREIIFTSGATEANNLAIKGVAEAYFQKGRHIITVETEHRAVIEPCEYLQSLGFEITFLPVEKNGLLNLELLTKTIREDTILVSVMTANNEIGVIQDIEKIGAICRENEVIFHTDSAQAIGKIPLDVQKMNVDLMSFTAHKIHGIKGIGALYIRAKNPRVNIASQIQGGGQERGYRSGTLCTPQIVGFAEAINIALKEMEQENQRQKNLRDYLWQELKQLDGIYLNGDLNQRLAGNLNISVEGVNGSALLLALQSQIAVSSGSACSSTSTKPSHVLKALGYSDELARASLRFGIGRFNTFEEIKETASFTLQTIKTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U8</accession>
    <name>K9Z8U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221299.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3551"/>
    <dbReference type="EnsemblBacteria" id="AFZ55584">
        <property type="protein sequence ID" value="AFZ55584"/>
        <property type="gene ID" value="Cyan10605_3551"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3551"/>
    <dbReference type="eggNOG" id="COG4474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108363_3_0_3"/>
    <dbReference type="OMA" id="HHRNDYL"/>
    <dbReference type="OrthoDB" id="1535236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="19055" checksum="52D0FEC70CD76E66" modified="2013-03-06" version="1">MKFASVTGHRYIVDNSMNRKAVNHLINLAVESGIEKFLVGMSRGADFLFARVLSERKLSWIAVIPCTDQTCLWNENDRTRHKGLIDKADNVIILSNEYKHGVMHHRNEYMVDKSEMLLAIYDNSVSGGTAHTVNLALKKHKRVVQFNPKTYEFYAIKSRQLSLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z901</accession>
    <name>K9Z901_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2786"/>
    <dbReference type="EnsemblBacteria" id="AFZ54853">
        <property type="protein sequence ID" value="AFZ54853"/>
        <property type="gene ID" value="Cyan10605_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2786"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2961"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076038_0_0_3"/>
    <dbReference type="OMA" id="GHVIYFR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938656" evidence="2">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="27425" checksum="87A3AFE27794874D" modified="2013-03-06" version="1" precursor="true">MKKSKSLELLMAIGLTATLSSTSSFVNAQENSHNNTNIPPFLLAQGGEGGEGGEGGEEYSEGEQANADFKDKMNGKQLLDSLKQGGYVIYFRHAETEKDYADQVTAVMGNCSTQRTLSEYGWNQAKMIGEAFRKYSIPVADVIASQYCRAWQTADLAFGRHVKNGDLNFPKAEDYTDEQVADMKARLIPMLTKLPPQGENTVIVGHDDLFEAATGIYPAPQGLAYVVKPDGNGGFELIANLLPEEWMKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z905</accession>
    <name>K9Z905_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding protein, PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220804.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55085">
        <property type="protein sequence ID" value="AFZ55085"/>
        <property type="gene ID" value="Cyan10605_3026"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3026"/>
    <dbReference type="eggNOG" id="COG5378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147223_1_0_3"/>
    <dbReference type="OMA" id="QHLENHA"/>
    <dbReference type="OrthoDB" id="1838295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10130">
        <property type="entry name" value="PIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="146" mass="16899" checksum="E0B6395BAA3DE9CC" modified="2013-03-06" version="1">MFLVVDANILIGELLRKRGQEIILNPMLTLYVSERVFSEANYELDKRVNFMIQQKRLTQNEGKKRLGDAKLIVESLNMVIFSDYQHLENHAKNLIPRDLNDWETVAISILLDVDIWTKDSDFIGCGRATWTTDTLIYLINANLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z916</accession>
    <name>K9Z916_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220595.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2806"/>
    <dbReference type="EnsemblBacteria" id="AFZ54873">
        <property type="protein sequence ID" value="AFZ54873"/>
        <property type="gene ID" value="Cyan10605_2806"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2806"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2983"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="OMA" id="SHNWIRR"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13524" checksum="F7E517FA812A9502" modified="2013-03-06" version="1">MNKEIEKRLNLTKQQIRDFCQENNIQELSLFGSVLRDDFNDNSDLDFLVVFKPEFQLSLMDLVDIQYQLENLTRRKVDLIEKSSILDSYNWLRRQHILDTARVIYELRSILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A1</accession>
    <name>K9Z9A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220687.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2906"/>
    <dbReference type="EnsemblBacteria" id="AFZ54968">
        <property type="protein sequence ID" value="AFZ54968"/>
        <property type="gene ID" value="Cyan10605_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2906"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3093"/>
    <dbReference type="eggNOG" id="ENOG502ZBTH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098227_1_0_3"/>
    <dbReference type="OMA" id="RECKQRM"/>
    <dbReference type="OrthoDB" id="1777623at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021511">
        <property type="entry name" value="DUF3172"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11371">
        <property type="entry name" value="DUF3172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20124" checksum="86B86A9281ECA81A" modified="2013-03-06" version="1" precursor="true">MNRRPKSSYSRYSEPPSRKSTKSSPLENINYTLAAICAGIFILGVGVGIALSSGQTISTQNVASREVIDRSAPNPEICVQFGASAIVSDLRVFVTLNPFNVYVTQPNMRPGCVLKRNNWSILEQRRLVSDNDVRQCKNRMNTFGFTGTLESSPKIDCIYQNDSAGNLFLNPEGAVNPQGVQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H4</accession>
    <name>K9Z9H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin synthesis protein P47K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221095.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3335"/>
    <dbReference type="EnsemblBacteria" id="AFZ55377">
        <property type="protein sequence ID" value="AFZ55377"/>
        <property type="gene ID" value="Cyan10605_3335"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3335"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3551"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_1_1_3"/>
    <dbReference type="OMA" id="TEMNSGC"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="38000" checksum="814DCDB65413EBE3" modified="2013-03-06" version="1">MDSLILPKRGLPVTIITGFLGSGKTTLLNHILTNNQDLKVAILVNEFGDIDIDSQLLISVEENMVSLSNGCICCTINDDLLDTVFQILESDKKIDYLIVETTGVADPLPIILTFLSPELRDLIRLDSVLTLIDADNFTSEHFDSDAALKQIIYGDIIILNKVDLVSETKIKQLEEDILCIKNRANILCSQYGKVPLPLILDINSHNSNNYSLEKSKQKQHHHHHNHDHDHDHHHSHHLEIDGFISISFECDRPFNVDKFQNFITDNIMSQVYRAKGILWFAESQLKHIFQLSGKRYDIDTEEWQTNPKNQLVMIGRNIDENQLKTKLKECLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9I4</accession>
    <name>K9Z9I4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ordered locus">Cyan10605_3186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3186"/>
    <dbReference type="EnsemblBacteria" id="AFZ55235">
        <property type="protein sequence ID" value="AFZ55235"/>
        <property type="gene ID" value="Cyan10605_3186"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3186"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3396"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_0_3"/>
    <dbReference type="OMA" id="IICVDNR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="19962" checksum="FDAB218F20C82A87" modified="2013-03-06" version="1">MAYSLELYLEDLFFTPQNQIPLIKEENWQIYLEKWLNSLDLDFDPTKIYEMTLRLTNDEDIKSFNAQFRDKNQPTDVLSFAALETDFPDFDMDLVALGDVIISVETAEKQAQLHLHSLEIELLWLASHGFLHLLGWDHPDDESLKEMLNLQKFLLHTIGIESESLKEWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K3</accession>
    <name>K9Z9K3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3003"/>
    <dbReference type="EnsemblBacteria" id="AFZ55063">
        <property type="protein sequence ID" value="AFZ55063"/>
        <property type="gene ID" value="Cyan10605_3003"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3003"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3199"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037292_0_0_3"/>
    <dbReference type="OMA" id="SASAHTW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="100"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="547" mass="63952" checksum="B390695D0EB84116" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L1</accession>
    <name>K9Z9L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221130.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3370"/>
    <dbReference type="EnsemblBacteria" id="AFZ55412">
        <property type="protein sequence ID" value="AFZ55412"/>
        <property type="gene ID" value="Cyan10605_3370"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3370"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_0_2_3"/>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15457" checksum="8CF75F877C1F2E89" modified="2013-03-06" version="1">MKLHQQVIQVKTSGKCLHKITSQVNDVVINSGINTGLCTVFILHTSASLIIQENADPDVLADLSSFFSKLVSESADYLHSAEGVDDMPSHIRSVLTSTSENIIIHQGRLWLGTWQGLYLWEHRMRSHLRQIAIHIQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9X3</accession>
    <name>K9Z9X3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221103.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55385">
        <property type="protein sequence ID" value="AFZ55385"/>
        <property type="gene ID" value="Cyan10605_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3343"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3561"/>
    <dbReference type="eggNOG" id="COG4828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136765_1_0_3"/>
    <dbReference type="OMA" id="RRDINQF"/>
    <dbReference type="OrthoDB" id="2000842at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13464" checksum="0C3510CD749CBA5E" modified="2013-03-06" version="1">MEFIEHLEEGLVYIATLAKIFLEALGIITVTMGIIINLHHIIYLCHHPNNHIYNIVRTRVARSLALALEFQLGADILATTVGATYESLGKLAIIAIIRTFLNYFLSKEIKELNLDNHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAC0</accession>
    <name>K9ZAC0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221036.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55318">
        <property type="protein sequence ID" value="AFZ55318"/>
        <property type="gene ID" value="Cyan10605_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3272"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3487"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_1_2_3"/>
    <dbReference type="OMA" id="DDYSIGR"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="18049" checksum="4218461FE38119C7" modified="2013-03-06" version="1">MNAKLYDTRLDLSAEIREKVVQILNLTLATTLDLKTQTKQAHWNVKGNDFFQLHELFDEMAGELEEYVDMVAERVTALAGVALGTARVASQTSLLPEYPLEITAGLDHVSALADRYATYAAHVREAISKTDDLGDADTADLYTEISRTIDKRLWFLEAHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAI3</accession>
    <name>K9ZAI3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3361"/>
    <dbReference type="EnsemblBacteria" id="AFZ55403">
        <property type="protein sequence ID" value="AFZ55403"/>
        <property type="gene ID" value="Cyan10605_3361"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3361"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3579"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_3"/>
    <dbReference type="OMA" id="RLVHAYF"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13890" checksum="2599F74B382F6444" modified="2013-03-06" version="1">MTAIDDFTRLKHIADACQEALDFIKGITRQELENDRMLSLALVKELEIIGEATNHISSELKNRHPDVSWQDMIGMRNRLVHVYFGINYDIVWQTITENLPILLAQINDILKLDFPQNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAQ8</accession>
    <name>K9ZAQ8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3438"/>
    <dbReference type="EnsemblBacteria" id="AFZ55478">
        <property type="protein sequence ID" value="AFZ55478"/>
        <property type="gene ID" value="Cyan10605_3438"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3438"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249682_0_0_3"/>
    <dbReference type="OMA" id="VNAECHF"/>
    <dbReference type="OrthoDB" id="1589236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025569">
        <property type="entry name" value="DUF4335"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14233">
        <property type="entry name" value="DUF4335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="222" mass="25031" checksum="765A97BA5B17869E" modified="2013-03-06" version="1">MSSSIERQYMSPNCVLSLQGFSEESDNQEAISVMSVLTLAKCQIIGNSTTLQGGLTFLEHLLHAVSSYTHDLLSGLNHPVESKDKNDYIYLTNLEDKKRHLLIWQKEKGQTDDQLELELTTVQLFDLLDALDQLYQDPLTLPQLKDEIKPLSRRHRQAEVSFVEQSTPATLGFVGFTLAAIALFFIPNPNNIKDPNQEPQPARETNQQVIPVETPSKPNENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAU6</accession>
    <name>K9ZAU6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221231.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3477"/>
    <dbReference type="EnsemblBacteria" id="AFZ55513">
        <property type="protein sequence ID" value="AFZ55513"/>
        <property type="gene ID" value="Cyan10605_3477"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3477"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3703"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250123_0_0_3"/>
    <dbReference type="OMA" id="ERSEWIC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="389"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="467"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="735"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="787"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="859"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1472" mass="169407" checksum="C485DCE95F6F9002" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZA3</accession>
    <name>K9YZA3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217998.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0107"/>
    <dbReference type="EnsemblBacteria" id="AFZ52266">
        <property type="protein sequence ID" value="AFZ52266"/>
        <property type="gene ID" value="Cyan10605_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0107"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.110"/>
    <dbReference type="eggNOG" id="ENOG50302MH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073961_3_0_3"/>
    <dbReference type="OMA" id="REVDPFN"/>
    <dbReference type="OrthoDB" id="1516789at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021920">
        <property type="entry name" value="DUF3531"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12049">
        <property type="entry name" value="DUF3531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="17166" checksum="6F3F377E65EBA27F" modified="2013-03-06" version="1">MEINFREFNPFDLWIWLEFDHVPSEMEKQYVEELFNSWFYIGKLGGFNAENLQIQDTGIDISYLQYDYDFADNAMMSPMHNMGEFEYVGNWGRCWFDLGTSDLIALDVLINSLRELAKEYVGIIQLIIGGENEDWTVEKRNDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZD7</accession>
    <name>K9YZD7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218001.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0110"/>
    <dbReference type="EnsemblBacteria" id="AFZ52269">
        <property type="protein sequence ID" value="AFZ52269"/>
        <property type="gene ID" value="Cyan10605_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0110"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.113"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_3"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="31349" checksum="66956CB759D00CAE" modified="2013-03-06" version="1">MTQSLTIRNYHFEWGKRTYLMGILNVTPDSFSDGGNFCSVDNAVKQALKMVDEGADIIDIGGQSTRPGAKQITLEEELNRVIPVVQALRQKSDIPISVDTTRSEVAKEAIASGADIINDISGGTFDQEMLPTIAKLNVPIILMHIKGTPETMQSLTDYQDLIGEIQDFLQKQINQATNLEIKKEHIIIDIGIGFAKNYEQNIELLRAISQFKLMNFPLLVGTSRKSFIGKILNQDDPKKRVWGTAASCAYAITQGVDILRVHDVAPMYDIVRVTDAISRRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZP3</accession>
    <name>K9YZP3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218116.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0230"/>
    <dbReference type="EnsemblBacteria" id="AFZ52384">
        <property type="protein sequence ID" value="AFZ52384"/>
        <property type="gene ID" value="Cyan10605_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0230"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979038_0_0_3"/>
    <dbReference type="OMA" id="RYIIMFL"/>
    <dbReference type="OrthoDB" id="1144296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="284" mass="32026" checksum="5CAA4A08BD0D9D21" modified="2013-03-06" version="1">MSDKKKESQPFLPKIVRRFQKTLSSFINAIAEAITSSVHIPEIAIGPIIGSLITAITTLIIGLVTISNIFSEQFLYRPLQIQDNNANYTLELARYQQTILTDYLNHATQLTLDYPLWKLQQNPYLLRSLTQTVLKEIDGERKRYIIMFLKDSFFLNSPSQEPPSLLKEADLTEANLSKLDLTASNFSGSNLSKANLSHTNFHKSNLKNANLNNANLTNADLRGANLSKIEATNTNFTNACYDVFTQFDSNFDPIKANMQQIDSFSNCPYIKDVSENSNKKSTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZY5</accession>
    <name>K9YZY5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218247.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0371"/>
    <dbReference type="EnsemblBacteria" id="AFZ52516">
        <property type="protein sequence ID" value="AFZ52516"/>
        <property type="gene ID" value="Cyan10605_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0371"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.391"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_5_3"/>
    <dbReference type="OMA" id="RPWVEGL"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="23435" checksum="7EBB7DA1D45FB722" modified="2013-03-06" version="1">MSQDQTNSQIVKTKKTVYHLVNSFVVKPIFGTYFRGKVTGKEKVPLEGKLIIVSNHASVFDPPLLSAGIPRPVSYMAKQELFTEGFFGNLIKSLGAYPVNREGFDRKAIRQAVSLLEEGWATGIFIEGTRTPDGRIHNPKLGAALIAAKAQAPLLPVALCGTEKIVVKGQKLPKSVKVHLKIGDIIPPPTSGKKENLETITAQCASAINQLVDCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZY9</accession>
    <name>K9YZY9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218252.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0376"/>
    <dbReference type="EnsemblBacteria" id="AFZ52521">
        <property type="protein sequence ID" value="AFZ52521"/>
        <property type="gene ID" value="Cyan10605_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0376"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.396"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_2_0_3"/>
    <dbReference type="OMA" id="GWGFYRA"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="9">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="528" mass="58543" checksum="1D4009225D2642AF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z049</accession>
    <name>K9Z049_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218275.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0400"/>
    <dbReference type="EnsemblBacteria" id="AFZ52544">
        <property type="protein sequence ID" value="AFZ52544"/>
        <property type="gene ID" value="Cyan10605_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0400"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.423"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_1_3"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="30725" checksum="9C2AE9DCBBC6D1C4" modified="2013-03-06" version="1">MIPNSLILDTLIKDWLLEDIGRGDRTTESIFADNKIGKAHWIIKETGVIAGLPIAEKVFEILDPMAKCERLVLEGEKQEKGTKILTIEGKISALLTGERVALNLVMRLSGIATEARKYVEAIRDYPTKLVDTRKTIPGLRILEKYASAVGGATNHRIGLDDGIMIKDNHIQGAGGIKEAVDKVRKNMPYPLSIEVETSDLTQVEDAIASGVEIIMLDNMAIETMKEAVKLIRKSNPLTKIEASGNVTLDNIRSIAATGVDYISTSAPITRSSWLDISMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z064</accession>
    <name>K9Z064_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218290.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0415"/>
    <dbReference type="EnsemblBacteria" id="AFZ52559">
        <property type="protein sequence ID" value="AFZ52559"/>
        <property type="gene ID" value="Cyan10605_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0415"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.439"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107036_0_0_3"/>
    <dbReference type="OMA" id="PDWAIEI"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21195" checksum="DE10AE1A53FB9035" modified="2013-03-06" version="1">MVTTVKPKLTLENFLQQPETKPASEFIDGKITQKPMPQGQHSRIQYKLCAVINNIAETEKIACAFPELRCNFESKSIVPDVVVLEWDKIPLTDTGKIANRINTYPDWCIEILSPEQSLTQVLDKLLLCSQFGTQLGWLINPEEEAIFALLPEQKLRLFKNNDPLPVLEKVNLKLTVNEIFNWLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F9</accession>
    <name>K9Z0F9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/proton antiporter NhaS3, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0529"/>
    <dbReference type="EnsemblBacteria" id="AFZ52671">
        <property type="protein sequence ID" value="AFZ52671"/>
        <property type="gene ID" value="Cyan10605_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0529"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.559"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_3"/>
    <dbReference type="OMA" id="FIIGPHT"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="32"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="459" mass="48133" checksum="93BC43ADF8FECD42" modified="2013-03-06" version="1">MLNFSVSNLFFATATEADKAPLVLTGVLLTLAIIYITSKLGGELSRLVNLPPVLGELVGGVIVGVSALNLVVFPETSEASTSQIMNFLQFFTPMNPEFLSEVFASQSEVISVLAELGVVVLLFEIGLESDLRELKSVGYQAAIVAVVGVVAPFALGTVGLIYFFHFPTIPAIFAGAALTATSIGITSKVLSELGYLKAKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEVNLTQVILLIVSASAFLIGSILLGKFFNQSFMAIADKLKTRGNLVIPAFTFALLMAFLANVIHLEAILGAFAAGLVLDETDKRKELDKQVIPIADVIVPVFFVTVGARVDLSVLNPLIPENRAGLAIASFLIVVAIIGKVITGWAVFGQPNINRLAIGIGMIPRGEVGLVFAGIGSTSGVLSKPLEAAIIIMVILTTFLAPPLLKLVLKKPETGVPTTDNSVKELASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K2</accession>
    <name>K9Z0K2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photosystem II reaction center protein H</fullName>
            <shortName evidence="7">PSII-H</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psbH</name>
        <name evidence="8" type="ordered locus">Cyan10605_0570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, numerous small proteins, at least 3 peripheral proteins of the oxygen-evolving complex and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PsbH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218442.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0570"/>
    <dbReference type="EnsemblBacteria" id="AFZ52711">
        <property type="protein sequence ID" value="AFZ52711"/>
        <property type="gene ID" value="Cyan10605_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0570"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.601"/>
    <dbReference type="eggNOG" id="ENOG50332MV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190203_0_0_3"/>
    <dbReference type="OMA" id="PLMAVFM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00752">
        <property type="entry name" value="PSII_PsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001056">
        <property type="entry name" value="PSII_PsbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036863">
        <property type="entry name" value="PSII_PsbH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34469">
        <property type="entry name" value="PTHR34469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00737">
        <property type="entry name" value="PsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161025">
        <property type="entry name" value="SSF161025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7352" checksum="20999F23EB71A9F1" modified="2013-03-06" version="1">MAQRTGLGNLLRPLNSEYGKVVPGWGTTPLMAVFMVLFLVFLLIILQIYNSSILLEGIDVDWRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L6</accession>
    <name>K9Z0L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217999.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0108"/>
    <dbReference type="EnsemblBacteria" id="AFZ52267">
        <property type="protein sequence ID" value="AFZ52267"/>
        <property type="gene ID" value="Cyan10605_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0108"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.111"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_0_3"/>
    <dbReference type="OMA" id="GYNQSEC"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24665" checksum="1F85CA415E00DF54" modified="2013-03-06" version="1">MLNNFLSLFLKDNCPLCQRTAEKIICSYCQQKIDLCQLDSSQELTSDNFLIFAWGKYDGTLKRAIASLKYNGNRNLGVLMGQWLGKKWLDSGNKEKYKKLTVIPIPLHPEKLKQRGFNQAELIARGFTRITGYSLKPNLLQRVKDTTAMFGLNPSARKKNISKAFEIGKDLATINKSYPTLIVDDIYTTGTTVNEARQVLTKHKLLSVGVATLSKVNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q8</accession>
    <name>K9Z0Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/proton antiporter NhaS3, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217897.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z0Q8"/>
    <dbReference type="STRING" id="755178.Cyan10605_0004"/>
    <dbReference type="EnsemblBacteria" id="AFZ52165">
        <property type="protein sequence ID" value="AFZ52165"/>
        <property type="gene ID" value="Cyan10605_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0004"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.5"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_3"/>
    <dbReference type="OMA" id="CAWATTA"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="30"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="452" mass="47020" checksum="1DB4526FF0B8ABF2" modified="2013-03-06" version="1">MAWFYPVFATATSTETASPTLILAGVLLTLIVIYFASKVGGELCSRIGLPAVLGELVGGVVIGVSALKLVIFPEGGLSGDESLIIQFLETTANLEPSSAEKVFDTVSEVISIFSELGVIILLFEIGLESDLKELIRVGPSASVVAVAGVVVPFALGTFGLDYFFHLPLIPSIFAGAALTATSIGITAKVLAELGQLSSKEGQIIIGAAVLDDILGIIVLAVVASLAKTGEIQISQIVYLIISAGAFLIGAILIGRLISPWLVGLVNQMKTRGDILITGLIFAFTLAYIANVIQLEAILGAFAAGLILAETEKRKELEEQIIPVADMFVPIFFVCVGAKTDLSVLNPAVPSNREGLIIASFLIVVAIIGKVVAGFTIWAQPEVNRLAVGVGMIPRGEVGLVFAGVGAASGALSPATDAAIIVMVIVTTFVAPPLLKLVFKEPVPTTETETKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U3</accession>
    <name>K9Z0U3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ordered locus">Cyan10605_0640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218510.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0640"/>
    <dbReference type="EnsemblBacteria" id="AFZ52779">
        <property type="protein sequence ID" value="AFZ52779"/>
        <property type="gene ID" value="Cyan10605_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0640"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.676"/>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_0_0_3"/>
    <dbReference type="OMA" id="YQFGEYN"/>
    <dbReference type="OrthoDB" id="130048at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="467" mass="54470" checksum="8633C224724509B7" modified="2013-03-06" version="1">MINPFLNLEYEPAMENLGDDYYDVVTPAEFPQHILRFRNDDLLSIIGLSEDEVEDSHWVDAFGKFQGIRPFLALKYHGYQFGVYNPQLGDGRGFLYGQVRGRDGVLYDFGTKGSGRTPYSRQADGRLTLKGGVREIIAGEALFRMGVNTSRCLSLIETGEALWRGDEPSPTRSSVMVRFSKSHIRFGSFERLYYFQRPDLVKNLLDHVIYYYYPHLTMQDKPYTLFYSELIQRVALLVAQWMSAGFCHGVLNTDNMSITGESFDYGPYAFINTYDPTFTAAYFDYGGRYCYGNQPLICRWNLELLQKPLGLLISLEDLQQELAKFERVYQGYYQELMLKKLGFSQLRNNLGEKLVQETIDLLKESQYSYHQFFADLAEQFNYGWHNSYELILENSEIKSSNLDSWKRLYHLCLETFVREELDQIQCTLHQYNPQIVPIRAIIEAIWHPITTEDNWLPFYDLLAQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X5</accession>
    <name>K9Z0X5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218545.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0676"/>
    <dbReference type="EnsemblBacteria" id="AFZ52814">
        <property type="protein sequence ID" value="AFZ52814"/>
        <property type="gene ID" value="Cyan10605_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0676"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.712"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_3"/>
    <dbReference type="OMA" id="FQPGAYI"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="23964" checksum="C8E542DCEF6A3C07" modified="2013-03-06" version="1">MKYKVCYRPAFAAIFVTLEPRERITAEAGAMVSMDGDIVMKTEFSGGLIPALIRKFLGGESMFVNVFYNPTNRPLNLVLTQSMIGDIEAIKLENKSICFQPGAYIAHTPGAKMGVKWAGFASWFAGEGLFKLHFSGKGRVLFGCYGGITRREINGDFIVDNNHLVAYDDGIKMNITLSGNLLSSLTSGEGFVNKLTGRGAIYLQSRSVSGLVGFLSPKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y2</accession>
    <name>K9Z0Y2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218129.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0245"/>
    <dbReference type="EnsemblBacteria" id="AFZ52397">
        <property type="protein sequence ID" value="AFZ52397"/>
        <property type="gene ID" value="Cyan10605_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0245"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.254"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_7_2_3"/>
    <dbReference type="OMA" id="IRHGGKH"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="6871" checksum="7C0BDD2E851D207D" modified="2013-03-06" version="1">MKRKDLIKIIEKHGCILIRHGGKHNIYQNPDTGISQPIPRQKEINERLAKKIIKDLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z124</accession>
    <name>K9Z124_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="7">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lpxA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218595.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0730"/>
    <dbReference type="EnsemblBacteria" id="AFZ52864">
        <property type="protein sequence ID" value="AFZ52864"/>
        <property type="gene ID" value="Cyan10605_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0730"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.766"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_3"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="8">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="28249" checksum="C873226FEC777DA5" modified="2013-03-06" version="1">MIHPTAIIDPKAELDSTVQVAPYAVIGADVKIGANTTVGSHTVIEGPIEIGCDNQIFPGSALGLAPQDLKYKGAKSLVKIGDRNVIREYVTVNRATGEGETTIIGNDNLLMAYVHVAHNCILHDRIVIANSVAIAGHVEIESKAVIGGMLGIHQFVKIGTMAMLGGMSRIDRDVPPYMLVEGNPSHVRSLNLVALKRNNFSSEQVSLLKKAYKILYRSKLTVNQALEELQPLTDNEQIKHLVEFIRASANDSGRRGLINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z141</accession>
    <name>K9Z141_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylation/Crystallin J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0788"/>
    <dbReference type="EnsemblBacteria" id="AFZ52921">
        <property type="protein sequence ID" value="AFZ52921"/>
        <property type="gene ID" value="Cyan10605_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0788"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.829"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_7_0_3"/>
    <dbReference type="OMA" id="RQDRFHA"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="40338" checksum="18658F6021DDE9B4" modified="2013-03-06" version="1">MSNNDISSLLGILIGTAIGDSVGLPAEGISRQRNHKIFRHQWHQRLLWRYGMISDDTEHTIFVAQCLIAHPNSSEKYVGRLAWCLRWWLLSLPAGVGLATLKSIIKLWLGFNPRYSGVDSAGNGAVMKSAIIGAFFAYNQDKLREYVCLSTRITHSDPRALIGAEAIASLTAWIIRDKFTQPPQIETLSTFLKQIGDKNREWILLVDAIIESLKEDLSVLQFAEKIGQKKGVSGYVYHTVPVVIFTWYRHFGNFPQALSAIYDCGGDTDTTGAILGALMGATVGLKGIPEDWINNLRDYPRNIELLHKIAQKLSNTIHNNYQPSQPIFYGWWWVLPRNIIFLLIVLCHGFRRLFPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z178</accession>
    <name>K9Z178_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218650.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0786"/>
    <dbReference type="EnsemblBacteria" id="AFZ52919">
        <property type="protein sequence ID" value="AFZ52919"/>
        <property type="gene ID" value="Cyan10605_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0786"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.827"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_0_0_3"/>
    <dbReference type="OMA" id="FGNYWNY"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="577"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="727" mass="83589" checksum="AF4FCBE1A46D4DEB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M2</accession>
    <name>K9Z1M2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="8" type="ordered locus">Cyan10605_0485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFZ52627"/>
        <property type="gene ID" value="Cyan10605_0485"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.514"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1632367at2"/>
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        <property type="reaction ID" value="UER00151"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTP cyclohydrolase I activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="27239" checksum="BED375CDEB3DAD9A" modified="2013-03-06" version="1">MTEFSNNSNSKNVPNNHDSITTETYNNVASRPDRNTHNGKEAQIHEAKEENKIQMMDAVRNILDAVGEDPEREGLLKTPKRVAEAMQFLTQGYNQSLEKLVNGAIFDEGHNEMVLVRDIDFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQVQERLTRQIAEAIQTILDPQGVAVVMEATHMCMVMRGVQKPGSWTVTSAMIGEFQDNDKTRQEFLDLIRHKPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z7</accession>
    <name>K9Z1Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ52615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0473"/>
    <dbReference type="EnsemblBacteria" id="AFZ52615">
        <property type="protein sequence ID" value="AFZ52615"/>
        <property type="gene ID" value="Cyan10605_0473"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.501"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="171"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="645" mass="74206" checksum="303891ED0425A451" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z260</accession>
    <name>K9Z260_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218543.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0674"/>
    <dbReference type="EnsemblBacteria" id="AFZ52812">
        <property type="protein sequence ID" value="AFZ52812"/>
        <property type="gene ID" value="Cyan10605_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0674"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.710"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_0_3"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="25755" checksum="E0D65CC9BBA6A7A4" modified="2013-03-06" version="1">MLNKSEIKYRIEHNPAYGFLVLELEPNQTAIVEAGGMAAMDSSIKMESKMKGGFGQSFGRMLGGESLFLNEFTAQASQGELYISPGVPGDIQYYHLDGSKGLMIQSSGFVASSKNVEINSNFQGFKGFFSGESIFLLKATGKGDIWFSSYGAIVEINVENNYVVDTGYIVAFEDTLNYNVEMIGGLSFRNLRTGILGGEGLVCRFSGSGKLWIQSRGLYPLLNFLYPFRPVKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z261</accession>
    <name>K9Z261_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218950.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1097"/>
    <dbReference type="EnsemblBacteria" id="AFZ53219">
        <property type="protein sequence ID" value="AFZ53219"/>
        <property type="gene ID" value="Cyan10605_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1097"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1161"/>
    <dbReference type="eggNOG" id="COG0670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986288_0_0_3"/>
    <dbReference type="OMA" id="RTYRDDQ"/>
    <dbReference type="OrthoDB" id="1947455at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="242" mass="25350" checksum="79E2A36179B0D7DA" modified="2013-03-06" version="1">MATTSNFRNAIKKAQGQALVGPNVINKALPYLGGGLVLTAVGVYGGLGVIQSNPGIFMPTFFGAMIAELVLFFVVRGIAERADNGTALPLLAVYSLLSGYTLSGIVFVALGTAGVGLQGVGIAALGCGVTFVIARNVGSNLGEEDGLALTKTVQLGIMGLFVVILLQVVLGFFGVFTPSWLEVGISGLGVLLFAGASVVDFYLLPRAYRDEQYLCAALSMYLTYINLFIFILRLLIAINGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q4</accession>
    <name>K9Z2Q4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218586.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0720"/>
    <dbReference type="EnsemblBacteria" id="AFZ52855">
        <property type="protein sequence ID" value="AFZ52855"/>
        <property type="gene ID" value="Cyan10605_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0720"/>
    <dbReference type="eggNOG" id="COG3905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181431_0_0_3"/>
    <dbReference type="OMA" id="QWSSTIL"/>
    <dbReference type="OrthoDB" id="2096132at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9195" checksum="5620E18546F7A011" modified="2013-03-06" version="1">MNFNIYLEDELANDLIVIAKKSGKTRNSLVREAIHEYVNKQHHLQWSEKILNFNGVDDGIEFESYRDELLSPNDKGIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y2</accession>
    <name>K9Z2Y2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ordered locus">Cyan10605_0812</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218676.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0812"/>
    <dbReference type="EnsemblBacteria" id="AFZ52945">
        <property type="protein sequence ID" value="AFZ52945"/>
        <property type="gene ID" value="Cyan10605_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0812"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.855"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_3"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="125"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="320"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="475" mass="52325" checksum="9A1016A70F13B78E" modified="2013-03-06" version="1">MSGIDLQGKPFHFIGIGGIGMSALAYILAKRELPVSGSDIRASHITNRLEAVGATIFTSQNAENFERISWGNHGHYHKQEVQVVCSTAINQDNPEYKEAIAQGYPIYHRSDLLAALIKDYKSVAVAGTHGKTTTSSLIAYLLLESGLDPTVIIGGEVSAWEGNARLGESNYLVAEADESDGSLVQHHPEFGIITNIELDHPDHYESLDQLVGIFRQFAHQSKNVIACVDCPITRKYIQADITYSLNPQSGANYIATNIVHSPYGSEAEVWENGIWLGNISLELSGDHNISNALAAIAVGRKLGLNFATIADALSTFEGAKRRFEYKGTYQGATLIDDYAHHPSEIRCTLQAGRARLKQYDAQRLIAIFQPHRYSRTSAFLEDFAQCFAQADVVIVTDIYSAGEKNTEGINGEIVADYISKYHQEVYFQPNLHSLRDFLADFLEPEDLTLFLGAGNLNQIIPQLIALEEKSYAQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z319</accession>
    <name>K9Z319_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218479.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0609"/>
    <dbReference type="EnsemblBacteria" id="AFZ52748">
        <property type="protein sequence ID" value="AFZ52748"/>
        <property type="gene ID" value="Cyan10605_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0609"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.642"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030532_1_0_3"/>
    <dbReference type="OMA" id="FKWVAIL"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="413" mass="45574" checksum="9193FE44019AF5CF" modified="2013-03-06" version="1">MDNNIKNYALVTAAYWGYTVTDGALRMLVLLHFNKLGFTPIEIAFLFLFYEIFGIVTNFLGGWIGSQFGLRLTLYGGIGLQIFALVMLGLINPNWAVWFQVVYVMTSQAFSGIAKDLTKMSSKSAVRLVVPKEAESKLFKWVAILTGSKNALKGIGFFVGATLLQLFGFEKALFYQAAVLFIIFLSGRFLPKNLGKIKAKVKFKQLFSKSKAINILSAARFFLFGARDIWFVVALPVFFRMELGWSFIQVGTYMACWVIGYGIVQSLSPTILRQNQEGKAPQGKTIQIWTSILTIIPAAIALAFMAGFPPQIVITGGLIIFGIVFAFNSAVHSYLVLAYTEDDDVALNVGFYYMANSGGRLLGTITSGIVYQTMGIEGCLWFSSVFVLVAALVSAKLPPVKVLDSANELRHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z336</accession>
    <name>K9Z336_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe(3+)-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1458"/>
    <dbReference type="EnsemblBacteria" id="AFZ53569">
        <property type="protein sequence ID" value="AFZ53569"/>
        <property type="gene ID" value="Cyan10605_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1458"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1546"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="YRTGFWL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="36951" checksum="0B4072748C2B4A9A" modified="2013-03-06" version="1">MIATANLSENNDTRSLAVVETYKLSKVYVTGFWMNKKVPSLNDCTLKVYKGETFGLLGPNGAGKTTLLKTLLGIIRPTSGKALLLGKPLGDRQVKQRLGYLPENAYYYDFLTAWEFLSFIADLFKIPKSQQKQKILQLLDLVGLAKQTAQKKQLRQYSKGMMQRVGMAQALINDPEIVFFDEPMSGLDPLGRYQVRQIILSLKEQGKTIFFNSHVLSDVEKICDRIAILARGELLKVGSLDEILGTKKSYHVVLKQGENNNDWNQWLTHIKQENNFISGELTGNQEEFIHYVKSICAELISMNLSRDSLEEYFIRILEEKGITSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z359</accession>
    <name>K9Z359_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218524.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0654"/>
    <dbReference type="EnsemblBacteria" id="AFZ52793">
        <property type="protein sequence ID" value="AFZ52793"/>
        <property type="gene ID" value="Cyan10605_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0654"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.690"/>
    <dbReference type="eggNOG" id="ENOG5032YT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177114_0_0_3"/>
    <dbReference type="OMA" id="HTMWVEL"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="9687" checksum="22E51E2EE35E1236" modified="2013-03-06" version="1">MSILVDLRVKNVIIDDDDLAVEIMNGRTIKAPLACFPRLFNVSKQQLNNWQICGRGYGIHWEEIDEDISVEGLLRGAISPDYKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z375</accession>
    <name>K9Z375_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218544.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0675"/>
    <dbReference type="EnsemblBacteria" id="AFZ52813">
        <property type="protein sequence ID" value="AFZ52813"/>
        <property type="gene ID" value="Cyan10605_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0675"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.711"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_0_3"/>
    <dbReference type="OMA" id="AMVYMKG"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="24532" checksum="753BB69642CD821B" modified="2013-03-06" version="1">MDIQILQQPESAIAKITIEQNEELIAEAGTMIAMSDFINVSTTLRQGKGGGIMGGFKRMLAGESLFLSVFRCYQPQGEVFLAPSLMGDIITYEMQGQELIVQSASYLASASTVDMDLGFQGFKSFFSGESIFWLSITGYGPVILSSFGAIYEIDVDGEYIVDTGHIVAFERSLDFRIGKANSSWLGALLGGEGLICRFFGQGKVYCQTHNPGNFGRLIGSRLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z376</accession>
    <name>K9Z376_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218771.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53040">
        <property type="protein sequence ID" value="AFZ53040"/>
        <property type="gene ID" value="Cyan10605_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0910"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.957"/>
    <dbReference type="eggNOG" id="COG4238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110168_1_1_3"/>
    <dbReference type="OMA" id="FIVGQFK"/>
    <dbReference type="OrthoDB" id="2074260at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="9936" checksum="D62F2891440D2BDA" modified="2013-03-06" version="1">MSALTDNDLKELKDLITSKFESISKDLNDIKVDVATIKSDVNGLGKRLDDTNKRIDNLEFTNRGIFITVISGLLLAVITLTVKFLTPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D5</accession>
    <name>K9Z3D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218619.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0755"/>
    <dbReference type="EnsemblBacteria" id="AFZ52888">
        <property type="protein sequence ID" value="AFZ52888"/>
        <property type="gene ID" value="Cyan10605_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0755"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.793"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_1_3"/>
    <dbReference type="OMA" id="VNYSAPR"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="29904" checksum="D56E99BD2AC0D6A2" modified="2013-03-06" version="1">MISEQIINKLVELGTTVGLKILTALIIFLIGLQVAKWIKHLLETALTKKEVESTLVKFLGKILYIALISFVIIIALNQAGVAVTSIIAIFGAASLTVGLALQGSLSSLAAGISLIILRPFKIGDLIDGGGSFGIVEEIGLFNTTIKTLDNLTIIIPNDKIRNEKIINYSLKPIRRVDLVVSIGYGDDIDKAKQLVKEILSNDSRILADPAFTIHLFELADSSVNFAVRPWVKTSDYWDTYCDLTETIKKRFDEEGINIPFPQRDVHIYNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E2</accession>
    <name>K9Z3E2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase</fullName>
            <ecNumber evidence="6">2.5.1.147</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FO synthase subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cofH</name>
        <name evidence="8" type="ordered locus">Cyan10605_1120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The FO synthase complex consists of two subunits, CofG and CofH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218971.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1120"/>
    <dbReference type="EnsemblBacteria" id="AFZ53242">
        <property type="protein sequence ID" value="AFZ53242"/>
        <property type="gene ID" value="Cyan10605_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1120"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1184"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_3"/>
    <dbReference type="OMA" id="ATMMFGS"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
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    </dbReference>
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        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="368" mass="41227" checksum="36D34D978FCB5678" modified="2013-03-06" version="1">MILKTVSPFISFSEGVNLLQSNLQEHKQWLQNTADEMRHQQVGDTVTYVVNRNINFTNICEQHCSFCAFRRDQGEKGAFWLEIEDIIAKSTLAVEKGATEICMQGGLNPLAKVDGSSLKYYLKLVSAIKKSFPQLHLHAFSPQEIQFIAREDGLTYDDVIVALRDGGVNSLPGTAAEILDDTVRKIICPEKIDSQTWMDIISKAHRWGLYTTSTMLCGHIETYEQEMLHLTKVRSLQELALEKGYPARITEFILLPFVGEYAPQPLRKRVGKIQPDLEATLKLTAVARLFLGDIIPNHQPSWVKLGLHGAIEALSWGCNDIGGTLMEEHITTMAGAKGGTCLEVKEIQDAIASINRPFRQRNTLYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K2</accession>
    <name>K9Z3K2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1671"/>
    <dbReference type="EnsemblBacteria" id="AFZ53776">
        <property type="protein sequence ID" value="AFZ53776"/>
        <property type="gene ID" value="Cyan10605_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1671"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1773"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029517_1_1_3"/>
    <dbReference type="OMA" id="KEWRFRQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="43171" checksum="964791DDD57BE596" modified="2013-03-06" version="1">MVLTLPQPSKIWGQTSFAEIRGVWITKNDSDIWLDTPKLESSIQELAQLNFNTIYPVVWNSGYVSYDSAVAKRVGIPIIKAGNNKDMIAEITYQGHLNRLLVVPWFEFGFMAPPSSELALKHPRWLTNRRDGSKIGNSAAGQVVWLNPFHPQVQQFITDLVLEICTRYRVDGIQFDDHMALPRDFGYDPYTVNLYKQETKKNPPANPQDREWVKWRADKITDFMVRLNTLLKQRNPNFIFSVAPNPYSTAYNLFLQDWKRWVNLGIVDELIIQVYRPDLNSFVRELNVPEVQNARKKIPTGVAILTGLRNNPSPITLIEDKVRQARRYRLGVSFFYYETLWIEKPTETPDLRKAVVRALFYNPQPRFPVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N8</accession>
    <name>K9Z3N8_CYAAP</name>
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        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219091.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1244"/>
    <dbReference type="EnsemblBacteria" id="AFZ53362">
        <property type="protein sequence ID" value="AFZ53362"/>
        <property type="gene ID" value="Cyan10605_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1244"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1312"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016165_1_0_3"/>
    <dbReference type="OMA" id="AYYYLYT"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="60630" checksum="6A811E224A089DA2" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q0</accession>
    <name>K9Z3Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218916.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1061"/>
    <dbReference type="EnsemblBacteria" id="AFZ53185">
        <property type="protein sequence ID" value="AFZ53185"/>
        <property type="gene ID" value="Cyan10605_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1061"/>
    <dbReference type="HOGENOM" id="CLU_2011450_0_0_3"/>
    <dbReference type="OrthoDB" id="2068431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025578">
        <property type="entry name" value="DUF4359"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14271">
        <property type="entry name" value="DUF4359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="123" mass="14050" checksum="DEFB66987DAF3EA6" modified="2013-03-06" version="1">MKLSRISLLILGAFFLYGYFTNPSEQKFNEFITENTQGSLKDQICNANKSEDILSNLKSLTCNFVADQSSGAIEQFLSENTIRNNYLIFSIYQVKTPVYKSQTLGIFNQFFLLYQSSPIDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q3</accession>
    <name>K9Z3Q3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219106.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53377">
        <property type="protein sequence ID" value="AFZ53377"/>
        <property type="gene ID" value="Cyan10605_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1261"/>
    <dbReference type="eggNOG" id="ENOG5034465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871993_0_0_3"/>
    <dbReference type="OMA" id="KQRIHGF"/>
    <dbReference type="OrthoDB" id="1977029at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="15272" checksum="9710BC4EE76C0EC1" modified="2013-03-06" version="1">MNIFDKLEQDISNQIQSLQAKQQELIEKKKYLATTKEKIQNFLTSAQEIQQIVGGEPELLKSIQKELGKIFSSHNNPQPKLPIKKENSTTPNLESPPENKPIDSALKSADNSDDTEEGEAIKIFNFVDAQGKNTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q4</accession>
    <name>K9Z3Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate:AMP phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218921.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1066"/>
    <dbReference type="EnsemblBacteria" id="AFZ53190">
        <property type="protein sequence ID" value="AFZ53190"/>
        <property type="gene ID" value="Cyan10605_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1066"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1128"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033786_0_2_3"/>
    <dbReference type="OMA" id="SPLDWQQ"/>
    <dbReference type="OrthoDB" id="953793at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043751">
        <property type="term" value="F:polyphosphate:AMP phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022489">
        <property type="entry name" value="PolyP_AMP_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03708">
        <property type="entry name" value="poly_P_AMP_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="270"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="493" mass="58500" checksum="EE3ABBE6EF8EA265" modified="2013-03-06" version="1">MLDNLDLSNSLDKDTYRYKIEELMRELRSLQNICWLQKMPIIVVLEGWAAAGKGELVKQMTNYMDPRGFTVHPIFSPSEQEKQYPFLWRFWQKLPPVGSIGIFYHSWYTHVLEDRLFKRLEDERVPLIMRDINAFERQLVEDGTVVAKYWLHVSKKELKNRLKKYEKDELESWRVRKEDWQQVKNYEEYSHLAEEMLIYTSTGFAPWVLVEADCQRWAKMKVLTQLVATIREGLAKREIITATPSSAPQSQLLPTEPDYLGQTDLTLHLPKDEYKTKLKKYQVQLRQLQKDIYEHNIGVLLLFEGWDAAGKGGAIKRVTDILDPRSYEVHTFAAPTDEEKKHHYLWRFWRSLPALGKIGICDRSWYGRVLVERIEGFATEIEWRRAYREINEFEAQLATSNYIVLKFWLHISPEEQLNRFQDRKEDPYKRYKLTEEDWRNREKWDLYDVAVNQAIARTSTALAPWTVVPGNDKYYARVHVLETVVNAIKNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y5</accession>
    <name>K9Z3Y5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">Cyan10605_1158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219009.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1158"/>
    <dbReference type="EnsemblBacteria" id="AFZ53280">
        <property type="protein sequence ID" value="AFZ53280"/>
        <property type="gene ID" value="Cyan10605_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1158"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1225"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_1_3"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023254043" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023254042" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="191"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="413" mass="43446" checksum="92E8AFD1E9D98D37" modified="2013-03-06" version="1">MADWKVIEGGITAPKGFKSSGITAGLKPSNAPDLALIWSETEAIASGVFTTSEVRAACVDYCRQRLQDKASARAILCNAGQANAATGEQGWQDALDSASALAKELNIDANSILLASTGVIGQRIKMDAMLNAIPQLVSELSEDGGEATAKAIVTTDLVTKSIALETMIDGRPVRIGGIAKGSGMIHPNMATMLGFITCDGLVSTQLWQQMLKRAADKSFNQITVDGDTSTNDSLIALANGQSRTPAITSLDENGQKLEAMLTEVCQYLAKAIARDGEGATCLIEVEVTGASTEASARQIAKTIVGSSLVKSAIFGRDPNWGRIAAAAGRAGVPFKQEDLMIKLGDFLLMEKGQPLNFDRTSASNYLKQAAAGEYLKNDTVLISVSVGDGSSSGKAWGCDLSYDYVKINAEYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y7</accession>
    <name>K9Z3Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218824.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0963"/>
    <dbReference type="EnsemblBacteria" id="AFZ53093">
        <property type="protein sequence ID" value="AFZ53093"/>
        <property type="gene ID" value="Cyan10605_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0963"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1016"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_5_1_3"/>
    <dbReference type="OMA" id="MLAFDGS"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="218"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="31844" checksum="E90F8AF77D5D3F29" modified="2013-03-06" version="1">MKNILVCTDGSIIAKNIYHYGAWFAKRLNAQINVLSVTDIRSQKVVSTGNFSGAIGLGASEDLLEKLVELEHHKAQLNHEKSKLILKTAKEILQAEGVINVNLISKKGFLVDTLHEFESNNDLIVLGKRGENAEFASKHLGGNVERIIRSSHKPCLVVPLQFKPIERLLFAYDDSASCQKLLQLITSSPIFQGLELHLVTVTKDKKDQKAHVNLMKGQELATLAGFNPICLLIEGHPEEAIASYISENDISMLLMGAYGHNRIRQLVIGSTTIQILRSTQIPVFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z419</accession>
    <name>K9Z419_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219668.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1839"/>
    <dbReference type="EnsemblBacteria" id="AFZ53941">
        <property type="protein sequence ID" value="AFZ53941"/>
        <property type="gene ID" value="Cyan10605_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1839"/>
    <dbReference type="eggNOG" id="ENOG5033NF7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_4_0_3"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="8537" checksum="27418A64E7162A41" modified="2013-03-06" version="1">MIHIPLSDLSETVQNLVNQARMTGDNLTITGEGKPLAVIQPIKEKKRATFRVMKHRGKILGDIVEPTSNLVTWDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B3</accession>
    <name>K9Z4B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease, Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219756.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1935"/>
    <dbReference type="EnsemblBacteria" id="AFZ54031">
        <property type="protein sequence ID" value="AFZ54031"/>
        <property type="gene ID" value="Cyan10605_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1935"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2056"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_6_3"/>
    <dbReference type="OMA" id="ILQPYGQ"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="684" mass="76909" checksum="6FEF7760AC926CB9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D1</accession>
    <name>K9Z4D1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aat</name>
        <name evidence="5" type="ordered locus">Cyan10605_1901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219724.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1901"/>
    <dbReference type="EnsemblBacteria" id="AFZ53999">
        <property type="protein sequence ID" value="AFZ53999"/>
        <property type="gene ID" value="Cyan10605_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1901"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2018"/>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075045_1_1_3"/>
    <dbReference type="OMA" id="YRQGIFP"/>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="190" mass="21752" checksum="2EEC960393A3D679" modified="2013-03-06" version="1">MIDVPSIIQGYAHGNFLMADDKQQLGWYSSNQRALIPLDHQFHYPKSLRRVINQNRFSVAINQDFLGVCCGCAQRETTWISSELIQIYLELNKAGWAYSFETWQDGKLAGGILGIVIRGAFIGESMFYHVPDASKVAMVKLVEHLRQRNFILFDAQMQNPHLERFGSYIIDNRKYMGLLAKALEANCDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L0</accession>
    <name>K9Z4L0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ordered locus">Cyan10605_1408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219249.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1408"/>
    <dbReference type="EnsemblBacteria" id="AFZ53520">
        <property type="protein sequence ID" value="AFZ53520"/>
        <property type="gene ID" value="Cyan10605_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1408"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1488"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_0_3"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="298"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="588"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="841" mass="95570" checksum="C3E140D068D4B875" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L9</accession>
    <name>K9Z4L9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219259.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1419"/>
    <dbReference type="EnsemblBacteria" id="AFZ53530">
        <property type="protein sequence ID" value="AFZ53530"/>
        <property type="gene ID" value="Cyan10605_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1419"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1500"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_0_3"/>
    <dbReference type="OMA" id="WGEIGHI"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="436" mass="50688" checksum="49C4569501892CC9" modified="2013-03-06" version="1">MYGSQQVLLNPDKDTKSVLEYICIEANKLYNIGLYYARQIYFKEHRYITKFELDKEIKTNLHYRALRSCVAQQTLRSVYEGMSSYKTLKSKANKGDLHFKPKLPNYRKKGLYQAVYPARWVKLAKNNQLKFTLGKQTKVWFGIDHFYLQMPSNLNYKDIKEYRIIPRNGCFYLEFVYEQKIEPISLCQDNVLGIDHGINNWLTCVSNVGTSFIVDGKQVKSMNNWYNKKVAILKENRTQGFWSKRLMRITEKRNRQMRDAVNKSARIVINHCLQNNIGTIVFGWNQGQKQEANMGKKTNQKFVVIPTARLKDRIKDLSELYSIQFIEQEESYTSKASFLDLDFIPTHGEKPEIWKSSGKRVKRGLFRTANNLYINADCNGSANIIRKKVTAKSSILSNVNLDGVSMGALIHPQRIRLWSAKTKRSNVDLSHWSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P9</accession>
    <name>K9Z4P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219107.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1262"/>
    <dbReference type="EnsemblBacteria" id="AFZ53378">
        <property type="protein sequence ID" value="AFZ53378"/>
        <property type="gene ID" value="Cyan10605_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1262"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_6_1_3"/>
    <dbReference type="OMA" id="QMAGFAC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="610" mass="69910" checksum="9D3D2C5FDA11850B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R7</accession>
    <name>K9Z4R7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219864.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2050"/>
    <dbReference type="EnsemblBacteria" id="AFZ54139">
        <property type="protein sequence ID" value="AFZ54139"/>
        <property type="gene ID" value="Cyan10605_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2050"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2178"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110687_2_0_3"/>
    <dbReference type="OMA" id="RAKNTDI"/>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06296">
        <property type="entry name" value="RelE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12638" checksum="D85BBC1F49F67959" modified="2013-03-06" version="1">MTEIRYTLPFQRQLKQLAKRYRNIKNDIQPTVKELQKGNFVGNQIKGVQQTIFKVRAKNTDIPTGKSGGYRIIYQVISGEIVLLLLIYAKSDTANITVQEIEKIIKETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V9</accession>
    <name>K9Z4V9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1333"/>
    <dbReference type="EnsemblBacteria" id="AFZ53448">
        <property type="protein sequence ID" value="AFZ53448"/>
        <property type="gene ID" value="Cyan10605_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1333"/>
    <dbReference type="HOGENOM" id="CLU_3355708_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="36" mass="3903" checksum="56C915C2692AE958" modified="2013-03-06" version="1">MMIDNSQLDLILGIIALVIVIAGLVMLFQGVNTMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z555</accession>
    <name>K9Z555_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219604.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1775"/>
    <dbReference type="EnsemblBacteria" id="AFZ53877">
        <property type="protein sequence ID" value="AFZ53877"/>
        <property type="gene ID" value="Cyan10605_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1775"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1884"/>
    <dbReference type="eggNOG" id="COG0278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_2_1_3"/>
    <dbReference type="OMA" id="KGTKLMP"/>
    <dbReference type="OrthoDB" id="2001991at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014434">
        <property type="entry name" value="Monothiol_GRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005894">
        <property type="entry name" value="Monothiol_GRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00365">
        <property type="entry name" value="TIGR00365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12166" checksum="4C90DBC0240B1197" modified="2013-03-06" version="1">MTPELKQRIEDILKSDRIVVFMKGTKLMPQCGFSNNVVQILNTIGVPFQTFDVLSDYDIRQGIKEYSNWPTIPQVYVNGEFIGGSDIMIEMYQTGELQQMIEVALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z575</accession>
    <name>K9Z575_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(1-&gt;4)-alpha-D-glucan branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1592"/>
    <dbReference type="EnsemblBacteria" id="AFZ53700">
        <property type="protein sequence ID" value="AFZ53700"/>
        <property type="gene ID" value="Cyan10605_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1592"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1691"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_3"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="7"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="427"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="61662" checksum="C3D95FD4E892217B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z576</accession>
    <name>K9Z576_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220019.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2208"/>
    <dbReference type="EnsemblBacteria" id="AFZ54294">
        <property type="protein sequence ID" value="AFZ54294"/>
        <property type="gene ID" value="Cyan10605_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2208"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2346"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365126_0_0_3"/>
    <dbReference type="OMA" id="NLFWCPP"/>
    <dbReference type="OrthoDB" id="72038at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014903">
        <property type="entry name" value="DUF1796"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08795">
        <property type="entry name" value="DUF1796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="738" mass="85261" checksum="D111D951EA3A5CBF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F1</accession>
    <name>K9Z5F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219512.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1680"/>
    <dbReference type="EnsemblBacteria" id="AFZ53785">
        <property type="protein sequence ID" value="AFZ53785"/>
        <property type="gene ID" value="Cyan10605_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1680"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1783"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_1_3"/>
    <dbReference type="OMA" id="LWHHKHF"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17638" checksum="2A417A50CAB15EB3" modified="2013-03-06" version="1">MLNFKYSSVINAPIDKVWHFHEREDILQILTPPWQPVKVIRREGGLEVGATSEFVLMFGFINIPWIARHSQYEKYKQFTDEQIKGPMVSWTHYHQFQTEGANTRLTDKIEYEIPGGWLSEICLGWWVNSRLHDMFAYRHRVTKQHCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H3</accession>
    <name>K9Z5H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220160.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2352"/>
    <dbReference type="EnsemblBacteria" id="AFZ54436">
        <property type="protein sequence ID" value="AFZ54436"/>
        <property type="gene ID" value="Cyan10605_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2352"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136572_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938601" evidence="1">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="27156" checksum="BD80D73BA05F39A8" modified="2013-03-06" version="1" precursor="true">MKIKHLLITNISLFTLFSGPLQAQNSSFPTIINNNNSPFQQKLIDWGFSISNCDGNVVSIRDLNTQEIACVEPNQQISSGNYVYDRVTNQIRPDTNVDSDTANVSQTNTRGASQNIEEVVTEGYVNPNPSNADPRIADVVIDFVDIYGYNNCLDALLLLYEGRNPVGDNSCLQNVKEVFGNQISRDVMLELVDIANVRATSLLPMELYPAYGIRRRVAQSVGYVYEIDVDNPEMIRLAQSSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I2</accession>
    <name>K9Z5I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aluminum resistance family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219380.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1544"/>
    <dbReference type="EnsemblBacteria" id="AFZ53653">
        <property type="protein sequence ID" value="AFZ53653"/>
        <property type="gene ID" value="Cyan10605_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1544"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1639"/>
    <dbReference type="eggNOG" id="COG4100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037803_3_0_3"/>
    <dbReference type="OMA" id="YGHDDLG"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="44354" checksum="7ADDE304DB746493" modified="2013-03-06" version="1">MNIDLLIDSAQEKLLPTFAEIDQQVKHHLNKILTAFRDHRVGVHHFSSVSGYGHDDLGRDVLDQIFAQVFEAEKAAVRIQFVSGTHAIASCLYGVLRPNDEMLAVAGHPYDTLEEVIGVRGEGQGTLQEWGVKYRELALTDEGGIDWEGLATAVKPETKLVLIQRSCGYSWRQSLSVADIARVVQLVKKQNPDTVCFVDNCYGEFIEKSEPTAVGVDLMAGSLIKNPGGTIVTAGGYVAGREDLVEKACCRLTAPGIGSSGGATFEQNRLLFQGFFLAPQMVAEAMKSSHLIAYVFSELGYEVNPLPFTPRRDIIQAVKLGSPDKLVAFCRAIQKNSPIGSYLDPVPAPMPGYDTNLVMAGGTFIDGSTSEFSADGPLREPYIVFCQGGTHWTHTAIALKSALEAFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T3</accession>
    <name>K9Z5T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220232.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2428"/>
    <dbReference type="EnsemblBacteria" id="AFZ54509">
        <property type="protein sequence ID" value="AFZ54509"/>
        <property type="gene ID" value="Cyan10605_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2428"/>
    <dbReference type="HOGENOM" id="CLU_2715617_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8498" checksum="A4F2B26889CAA87C" modified="2013-03-06" version="1">MNINQSKSQFKTSDTIFATGVFLKPVKCVINDIEQWRWIVVSFEDDSYFDGNLIEVYEYSDTFEGLFIQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V3</accession>
    <name>K9Z5V3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1652"/>
    <dbReference type="EnsemblBacteria" id="AFZ53758">
        <property type="protein sequence ID" value="AFZ53758"/>
        <property type="gene ID" value="Cyan10605_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1652"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1754"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_3"/>
    <dbReference type="OMA" id="VYCPQAY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="85"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="507" mass="53679" checksum="8D864CA83000776A" modified="2013-03-06" version="1">MLIIKTHLTYNKRVKTESKAMLITRTQKRKIQLIINKIQKSSSWQGCVLLSVILLLCSSYAVYAQDSSTSLEIITGELKVGLDTLWVVIASILVIAMNAGFAMLETGFCRSKNAVNLLSKNLIVFAVSTLAFWAIGFGLMFADGNSFIGTQGFFLQGADNSPATGDAYEGVYNALSWAGVPLSAKFLFQVAFAGTAATIVSGAVAERVKFIDFLFFSFFLVAIAYPIIGHWTWGGGWLADAGFQDFAGSTVVHSVGGWCALTGAIILGPRLGKYLSDGGIVPLPGHNLSLATLGCFILWIGWFGFNPGSTMAVGEDIAYIAVVTNLAAASGGLTGTISSWVLAGKPDLSLSINGILSGLVAITAGCSMVSYSSAVTIGALAGILVVFSVYMLDKLKIDDPVGAVSVHLVNGIWGTIAVGLFADENITGDESIAGFFSNGTFALLGSQILGVVSVGIAMIIFSTMFWVVLRSIFGLRVSQEEEYLGLDIGEHGMEAYTGFFDFEGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W6</accession>
    <name>K9Z5W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219500.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1668"/>
    <dbReference type="EnsemblBacteria" id="AFZ53773">
        <property type="protein sequence ID" value="AFZ53773"/>
        <property type="gene ID" value="Cyan10605_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1668"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1770"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_3"/>
    <dbReference type="OMA" id="ALMGDGI"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="30936" checksum="7DFCCDABF9C13B8B" modified="2013-03-06" version="1">MIVFSSLVSWLLEPLQHSFMVKAIWVSAFVGIVCAVLSCYITLKGWSLMGDAVSHAVVPGVVVAYALNIPFALGAFIFGFGATVAIGYVKSKTRLKEDTVIGVIFTGFFALGLVLVTKIPSNIDLFHILFGNVLGISPEDIVQTLIAGGITLVVILIRRKDLLLFCFDPNHAKAIGLNTKTIYYTLLSLLALTIVTALQTAGIIMVVAMLVTPGAIAYLLTDRFDQMLILSIVSSVLSCVLGTYLSYHFDVSTGGSIVVLMTIIFILAMIFAPKYGIINQNTKIYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X8</accession>
    <name>K9Z5X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name evidence="4" type="ordered locus">Cyan10605_2468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220272.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2468"/>
    <dbReference type="EnsemblBacteria" id="AFZ54549">
        <property type="protein sequence ID" value="AFZ54549"/>
        <property type="gene ID" value="Cyan10605_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2468"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2615"/>
    <dbReference type="eggNOG" id="COG1489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052299_2_0_3"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="OrthoDB" id="1375946at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="27480" checksum="284D94ED243E7577" modified="2013-03-06" version="1">MSFLYKYPPLISGTLVRRYKRFLSDIELDNGELITAHCANTGPMIGLCKVGSRVMVSKSDNPKRKLAYTWEMIDVGEENHPIWVGINTGLPNRIVKLALEKHIINELAHQYTQIKNEVKFGHDGKSRIDFVLKAEESQPPIYLEVKNTTLAENNIAMFPDTETIRGQKHLKELIELSADAKPVMLYFINRSDCKHFTVGREFDQIYGRLFDEALDKGVKILPCRFDISPQGINYLGIAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z600</accession>
    <name>K9Z600_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219725.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1902"/>
    <dbReference type="EnsemblBacteria" id="AFZ54000">
        <property type="protein sequence ID" value="AFZ54000"/>
        <property type="gene ID" value="Cyan10605_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1902"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2019"/>
    <dbReference type="eggNOG" id="ENOG5031BJF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173842_0_0_3"/>
    <dbReference type="OMA" id="RMEGEND"/>
    <dbReference type="OrthoDB" id="1772082at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12799" checksum="89A4BF8D0FAE5BC3" modified="2013-03-06" version="1">MSQPIPPIVLPPVENPEKERSWLKKSLHQWLDNEFIPELVNETIANRAAQIFIRHRLEGENDLGSLVIAIVTEMQSFDFQKSFYSEFAIANAVSDIILQSLGIDTCCGNNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z604</accession>
    <name>K9Z604_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1715"/>
    <dbReference type="EnsemblBacteria" id="AFZ53818">
        <property type="protein sequence ID" value="AFZ53818"/>
        <property type="gene ID" value="Cyan10605_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1715"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1822"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062525_0_0_3"/>
    <dbReference type="OMA" id="LVWGYYI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="284" mass="32197" checksum="BE7BAD8553AC518B" modified="2013-03-06" version="1">MLLSHIKNYPIVVRLGLFVLALLFIWSPFLLSTYYFLGAKDPNLTTIITMAILFVIFLFLVKFWGQFVYDKSNIFKSYGLVFSRTNFLFLIKGLIIGFISNWLLFGVEFLLGWVSFQSPSLPLVKLLTEGFISAIGIGLAEELFFRGFLLWELERDFSLAFSAGLNAFIFAFLHFIKPLPEVIRTSVTFPALVILGYILVLGKRSHLNLLGISIGIHSGLVWGYYIVNVGQMVKYNNLVPSWITGIDKNPIAGVMGISFLLILLYSLKIDNKLRNKVKNDVNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z612</accession>
    <name>K9Z612_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219555.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1725"/>
    <dbReference type="EnsemblBacteria" id="AFZ53828">
        <property type="protein sequence ID" value="AFZ53828"/>
        <property type="gene ID" value="Cyan10605_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1725"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1832"/>
    <dbReference type="eggNOG" id="ENOG502ZBMS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120948_0_0_3"/>
    <dbReference type="OMA" id="TFAWAGE"/>
    <dbReference type="OrthoDB" id="1630101at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="18131" checksum="4005BC8DAB80E5E0" modified="2013-03-06" version="1">MNYLVAVLSDRIQAEDAYTALEKAGIPTKQISILGKGYKSADEFGLIKPEDEGRKNAIRMAYWLVPFGFFGGYTFDAITSIDTFGWAGEPFNHIIGGFLGAIGGAMGSFFVGGSIGLAEGSGDALPYRNRLNQGKYLIIVEGDQMTKNQATRILKVFEPENLQGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z641</accession>
    <name>K9Z641_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219595.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1766"/>
    <dbReference type="EnsemblBacteria" id="AFZ53868">
        <property type="protein sequence ID" value="AFZ53868"/>
        <property type="gene ID" value="Cyan10605_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1766"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1874"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_3"/>
    <dbReference type="OMA" id="RLMRYEY"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="80"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="218"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="54613" checksum="214295D56B4F8DEF" modified="2013-03-06" version="1" precursor="true">MIKKLGKIWQWLGFTFITIAIVITTHHVAFADVTPSTYRDLQFPPLAEIKLPEYERYQLDNGMVIYLIEDHRLPLISGNAVIRTGSRFDPPSQVGLAELTGSLIRLGGTANYSPEQLNSILEQKAAAIESSIDETMGSVSFSSLSYDLDTIFPLFAEVIQSPAFDSQQLEVLKTQAKGAIARRNDDPGNIASREFKKLVYGENNPYARTIEYNTLDNIQQSDIKNFHSKYVRPEGIILGIVGDFDSSQIKEKIAQYFGNWQGNSQVKPTFDTITSKQEKSKGIFIADQPQLTQSNILLGHLAGKLNDPNYPTLSVMNGVLNGFGGRLHNEIRSRQGLAYSVYGIWQGAYDYPGLFVAGGQTKTDTTTQFIKTMKEEIEKLRTQPITEAELNYAKDSILNSFVFKFQNPSQTLSRMMTYEYYDYPQNFIFDYQQGVKNTQIDDVLNVAQEYLHPDKIVTLVVGNEEEIKQELQTLGQNIKQIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z680</accession>
    <name>K9Z680_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S16 lon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219640.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1811"/>
    <dbReference type="EnsemblBacteria" id="AFZ53913">
        <property type="protein sequence ID" value="AFZ53913"/>
        <property type="gene ID" value="Cyan10605_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1811"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1922"/>
    <dbReference type="eggNOG" id="COG2802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048359_0_1_3"/>
    <dbReference type="OMA" id="MLDHTRK"/>
    <dbReference type="OrthoDB" id="1474822at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="24351" checksum="3343A672EF886099" modified="2013-03-06" version="1">MASSSIAVRELPLFPLPEVVLFPGRPLPLHIFEFRYRMMMNTILEYDRRFGVLMIDPISGEIAKVGCCAEIIHFERLPDDRMKVLTLGQQRFRLLEYVRQKPYRVGLVEWFEDLPPQENLQPKAEEVTTLLHDVVKLSAKLTDQKIELPENLPTQPIELSYWVASNLYGVASEQQALLEIDNTGERLQREADILATTRSNLAARTALKDAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z689</accession>
    <name>K9Z689_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Cyan10605_1821</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219650.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1821"/>
    <dbReference type="EnsemblBacteria" id="AFZ53923">
        <property type="protein sequence ID" value="AFZ53923"/>
        <property type="gene ID" value="Cyan10605_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1821"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1932"/>
    <dbReference type="eggNOG" id="COG1282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007866_4_0_3"/>
    <dbReference type="OMA" id="AMTSMPE"/>
    <dbReference type="OrthoDB" id="788546at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="7"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ53923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="479" mass="50253" checksum="E92CE98EC7D50807" modified="2013-03-06" version="1" precursor="true">MSQNLITVAYIGASALFILSLAGLSNQETAQKGNIYGISGMAIAFIATAFSPQVTNYTTLIGAIIPAVIIGAILASRVAMTAMPELVAILHSFVGLAAVLVGVGNYLQPESGLVGAEAFIHQIEIYVGVFIGAVTFTGSIVAFGKLRAIISSKPLMLPARHLLNIGMLGATIYLGYDFLHSEFGLQPLLIMTGIACLLGIHLVAAIGGADMPVVISMLNSYSGWAAAAAGFMLNNDLLIITGALVGSSGAILSYIMCKAMNRSFISVILGGFGEGSSNKSNSAQKQEVGEAVATNVEEVADLLVNAKNVIITPGYGMAVAQAQHGVSEITKLLRDRKINVRFGIHPVAGRLPGHMNVLLAEANVPYDIVLEMDEINEDFSETDVVLVIGANDTVNPSALEDPNSAIAGMPVLEVWKAENSIVMKRSLATGYAGVDNPLFYKENTKMLFGDAKANVDALLVALREKTSKGKANNKVLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A2</accession>
    <name>K9Z6A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent hemoglobin/transferrin/lactoferrin family receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219830.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2011"/>
    <dbReference type="EnsemblBacteria" id="AFZ54105">
        <property type="protein sequence ID" value="AFZ54105"/>
        <property type="gene ID" value="Cyan10605_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2011"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2137"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cell outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
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        <property type="entry name" value="BtuB-like"/>
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    </dbReference>
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        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TonB_Hb/transfer/lactofer_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TonB-hemin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TonB-hemlactrns"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
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        <location>
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            <end position="147"/>
        </location>
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            <end position="283"/>
        </location>
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        <location>
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            <end position="870"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="874" mass="97627" checksum="B781090A8C2C830B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H9</accession>
    <name>K9Z6H9_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_1915</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFZ54013">
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        <property type="gene ID" value="Cyan10605_1915"/>
    </dbReference>
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        </location>
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            <end position="575"/>
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            <begin position="79"/>
            <end position="475"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="575" mass="63924" checksum="3028021178DE1A1D" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q1</accession>
    <name>K9Z6Q1_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_2343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220151.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2343"/>
    <dbReference type="EnsemblBacteria" id="AFZ54427">
        <property type="protein sequence ID" value="AFZ54427"/>
        <property type="gene ID" value="Cyan10605_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2343"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2487"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="33214" checksum="F8A7D7D5383137A5" modified="2013-03-06" version="1">MLTNEIVTEAKKLIEKDSIALFEQIQFTKINTPLSSKEIATSYIKKGEGKTPVLLLHGFDSSVFEYRRLLPFLKKEYEVWALDLLGFGFTQRQANLNYSPHSIRTHLYHFWSTMINKPMILVGASMGGASAIDFCLSYPQAVEKLVLLDSGGLTKQPIIGKFLFPPLGYLATEFLRNLKVRQSISKTAYFNPEFASEDALRCAALHLQCENWSKALISFTKSGGYGSFAEELGQIRAETLILWGKNDKILGIKPASQFQELIPQSKLVWIDNCGHVPHLEKSEITAHHILDFVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V1</accession>
    <name>K9Z6V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220196.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2390"/>
    <dbReference type="EnsemblBacteria" id="AFZ54472">
        <property type="protein sequence ID" value="AFZ54472"/>
        <property type="gene ID" value="Cyan10605_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2390"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254216_0_0_3"/>
    <dbReference type="OrthoDB" id="1687556at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939142" evidence="1">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="24851" checksum="2495E57AB7256E7E" modified="2013-03-06" version="1" precursor="true">MFFKITYLLVAGIASLTLISGVKAQTFTDIKGNPYEQEINRATELNIVAGFPNQTFRPNQPVKREEAISMIVEALGTLTEIDLKEAPTTRTRPYLDVDENRWSYDKITWAQWNIQPEGSATGNFRPDDYITRTELVDFLRRAAEFLQVKLGKSSFLTPTVKEITFSDVSGYELQLTRQMSAYCNVASALNEKGDKFAPKKSANRDYTAAAIIRMLDCVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W7</accession>
    <name>K9Z6W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-regulated ABC transporter permease protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220658.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2870"/>
    <dbReference type="EnsemblBacteria" id="AFZ54936">
        <property type="protein sequence ID" value="AFZ54936"/>
        <property type="gene ID" value="Cyan10605_2870"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2870"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3050"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_5_2_3"/>
    <dbReference type="OMA" id="PNCESHQ"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="455" mass="51564" checksum="43464980A456E657" modified="2013-03-06" version="1">MMILTQENLKNTKDGYLGCLLQIAENQPLHLEGKLQTIVQEIRRKAANKVVKLNLPTTKDESWRFTDLSELYKQDLVYAQPQDLENQTLQEFILKEASNSRLVFVNGYYQANLSDTSGLNSEQIYVGNLTNLDDDKQEKIAQYLAKNEPENEVFTALNSTSLNDAFVVWVKANQEIKTPIHLLHLSVKEKTGSWHQPRILVVAEANSVLEFIEYYGATSFGCSDSARQQYYFTNAVTEIHLLDNAQVNHNRIQRESGDGFHIAQTMVNQAKNSRYTINEISLGGKLYRHNLQVNQEGEQTETYLHGLTMLQGKQLGDTHSEVNLNHPYGTVNQLHKYILDDAGHGVFNGRVYVPKLAQLTNAAQLNRNLLLSPKARINTKPELQITADNVKCAHGATVSQLEADEIFYLRSRGLNEYDARHLLIDAFAAEIIDNIPFASLRQRLTQCVTCRTIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X0</accession>
    <name>K9Z6X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219863.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2049"/>
    <dbReference type="EnsemblBacteria" id="AFZ54138">
        <property type="protein sequence ID" value="AFZ54138"/>
        <property type="gene ID" value="Cyan10605_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2049"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2177"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_3"/>
    <dbReference type="OMA" id="CDYWCYY"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0798">TonB box</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="AMIN" evidence="11">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="10">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="9">
        <location>
            <begin position="387"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="829" mass="91452" checksum="2E4DC9137EA44D3C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z717</accession>
    <name>K9Z717_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid binding OB-fold tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220710.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2929"/>
    <dbReference type="EnsemblBacteria" id="AFZ54991">
        <property type="protein sequence ID" value="AFZ54991"/>
        <property type="gene ID" value="Cyan10605_2929"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2929"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3116"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_5_1_3"/>
    <dbReference type="OMA" id="IYCGAFD"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="453" mass="50793" checksum="F38AE77F2F9B3F71" modified="2013-03-06" version="1">MVKIVKRRSLGVQPVYDIGVEKDHNFILANGLVASNCFNKSHSTAYAYVTYQTAYLKANYPVEYMSALLTASSDNQDKVEKYRENCLKMGIDVKPPDINLSQKEFTPQGDNILFGFSAVKNLGESAIDNILEVREEAGGKFANFADFISRVNLKTVNKRALETLIYAGAFDCIHSNRRQLLEGLDLMVSWVQKRLKEKETGQLNIFEQMMGNSTNTATETTTEISYESAPRLPRVEDFSPQEKLKSEKEHLGFYVSEHPLKPLKNKISILSPINLSELSSQKSRHKICTLAMLNTIKSHVDKNGNNMAFLTLEDISGQADGVIFASSYEQIKDNLVEDTPLIIWGRADNKNEKSQIIVNYMSKIAETKLVFIRLSPENASNPSIQGKIKGILQEQSGDKNQAVIPTFVVIEGARERIIVRLGDAYWVQDAYNTLEALTNASFDAYLQGFDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z797</accession>
    <name>K9Z797_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219968.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2157"/>
    <dbReference type="EnsemblBacteria" id="AFZ54243">
        <property type="protein sequence ID" value="AFZ54243"/>
        <property type="gene ID" value="Cyan10605_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2157"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2292"/>
    <dbReference type="eggNOG" id="ENOG5032Y9E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163891_0_0_3"/>
    <dbReference type="OMA" id="TIFLTRM"/>
    <dbReference type="OrthoDB" id="1975944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="11110" checksum="0B4ED56505A51E62" modified="2013-03-06" version="1" precursor="true">MSSFLGRFSLLWFLFFFGHFSAIALPPPDDIPEEVLATEIITEARSPLNNEPLTTEEYVTLTEKQANSKYPPQISSDIRQKIFLLRIINLIRTISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z798</accession>
    <name>K9Z798_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220340.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2537"/>
    <dbReference type="EnsemblBacteria" id="AFZ54617">
        <property type="protein sequence ID" value="AFZ54617"/>
        <property type="gene ID" value="Cyan10605_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2537"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2692"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104916_1_0_3"/>
    <dbReference type="OMA" id="EGQIDEF"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="27822" checksum="119D7C3DE6A157BB" modified="2013-03-06" version="1">MSKEIPALFQKTKFLEGQIDEFLDKIAEGAIHFEIGMTAFLGAGKVNQTSEEQLFQINSLKEKCSELRRTIVNILYTEMLIPDFRGDVLSLLTNLFSLLDALGKNFQELMIEHQEIESKSPSNSEEENNHIENQSSIQKENNLSEGELLLLVKMVVKSVEMVVVAARDFFRNPKAVRDHIYQVRVYESEADRISISIKKNIFSSNLKFSHKINLRDKVNAIDAIADKAEEVADELSIYAIQRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C4</accession>
    <name>K9Z7C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2393"/>
    <dbReference type="EnsemblBacteria" id="AFZ54475">
        <property type="protein sequence ID" value="AFZ54475"/>
        <property type="gene ID" value="Cyan10605_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2393"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2540"/>
    <dbReference type="eggNOG" id="COG5659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049561_0_0_3"/>
    <dbReference type="OMA" id="CKQELGW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="334" mass="39123" checksum="39A425FF92DA9EAC" modified="2013-03-06" version="1">MQGKKIILIVDETGDRKKGNKTDYTARQYLGNVGKIDQGIVSVNVYGVYQNITFPLMTKIYKPKSRLKVGDKYKTKTAIAGEMVRELKELGLEIEIVLADSLYGESSSFLEVLEELKLEYVVSIRKNHGVWMGANERVRANKWCKFTRTFRDGKRETRYIREIIYGKKRRITYWEMTTDTENLPKNSTSFVRTNCQGNLKKRLGDLYGQRTWVEYGFRQCKQELGWKDYRLTKIESIEKWWGLINSVYTMVSLQTKPLRELLFSEEEKKEEIEEKEQINSWKTSLKKIMMMIEPLVLFWLITPWLKMVNSSGLLEGLNNLLSITHGSKLYFPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G8</accession>
    <name>K9Z7G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220808.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3030"/>
    <dbReference type="EnsemblBacteria" id="AFZ55089">
        <property type="protein sequence ID" value="AFZ55089"/>
        <property type="gene ID" value="Cyan10605_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3030"/>
    <dbReference type="eggNOG" id="ENOG5033DAD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186047_0_0_3"/>
    <dbReference type="OMA" id="EGRQNDF"/>
    <dbReference type="OrthoDB" id="2053564at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="8227" checksum="69EC39B3E367A1C8" modified="2013-03-06" version="1">MISKTIDLSEEKIKELLKEVLIELMETKKDDFQELFLEVIEEIGLKNAIKEGRKNDFVAEEDIFLLLENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I3</accession>
    <name>K9Z7I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220263.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2459"/>
    <dbReference type="REBASE" id="58397">
        <property type="entry name" value="Cap10605ORF2460P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54540">
        <property type="protein sequence ID" value="AFZ54540"/>
        <property type="gene ID" value="Cyan10605_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2459"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2604"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244224_0_0_3"/>
    <dbReference type="OMA" id="FMSDERV"/>
    <dbReference type="OrthoDB" id="1362496at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="268" mass="30878" checksum="DFFEC5B4BD65FDA8" modified="2013-03-06" version="1">MSKYKYDAIIETVFFNNYKEGDEKVSFVREELAKACDTLNISRIKNLGDIPYKYRFRKDLPDSIKNKAPENTDWIIVGTGRASYEFRQATPGKIEVTKNRQLIKIPDATPEIVKRYAPGMDEQALLTKVRYNRLIDLFTGLTCYSIQNHLRTSIDTIGQIEIDEIYLGINKRGAHFVLPCQAKSPGDSFGIVQVMQDIEFCKIRYPNLICKPIALQFLSDNDVAILELSVEESQEKLRLSVVEEKHYQLVLKNDISEQEIKNICEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K1</accession>
    <name>K9Z7K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ordered locus">Cyan10605_2479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220283.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2479"/>
    <dbReference type="EnsemblBacteria" id="AFZ54560">
        <property type="protein sequence ID" value="AFZ54560"/>
        <property type="gene ID" value="Cyan10605_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2479"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2628"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_3"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="438" mass="49288" checksum="B8FECADB207570C5" modified="2013-03-06" version="1">MSDNLSNHFSQKLLDFDRNHIWHPYTSLINPLPTYPIVCAEGVRLIMDNGKQLIDGMSSWWTAIHGYNVPELNQVANEQLQKMSHVMFGGITHKPAILLCQKLVEITPKGLEKVFLADSGSVSVEVALKMAIQFQHSLGQPQKNKFMTIRRGYHGDTTGAMSVCDPEGGMHHLFRDFLPKHFFIEKPQKRFGETYEEEELFFLEEFFRLHSHQCAGFILEPIVQGAGGMWFYSSQFLKKIKSLCEVHNMLLIADEIATGFGRTGKLFACEHAGISPDILCLGKALTGGYMTLAATICTQRVAETICQGEAGVFMHGPTFMANPLACAIASKSIELLLKSDWQSKILTIEKELKQGLNEAKTLENVKDVRVLGAIGVIELHQPVNVAHAQKFFVEKGVWIRPFRNLIYIMPPYIISQKDLRLLTSTMVDYCQKINTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V2</accession>
    <name>K9Z7V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220383.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2583"/>
    <dbReference type="EnsemblBacteria" id="AFZ54660">
        <property type="protein sequence ID" value="AFZ54660"/>
        <property type="gene ID" value="Cyan10605_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2583"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600195_0_0_3"/>
    <dbReference type="OrthoDB" id="58293at1117"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9856" checksum="CFA0D93F3D6FA34A" modified="2013-03-06" version="1">MKELIYLLFFYRIKQDSFCNFIEIDFYRQNKEQLRKEVELIFDKPETYKADTAFSFYLPKSDMFLRRMIYVPFKDLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X1</accession>
    <name>K9Z7X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54832">
        <property type="protein sequence ID" value="AFZ54832"/>
        <property type="gene ID" value="Cyan10605_2764"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2764"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2935"/>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="8889" checksum="93BFF677B4D44319" modified="2013-03-06" version="1">MDLVVICYQLTSLFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIIGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y4</accession>
    <name>K9Z7Y4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221019.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3255"/>
    <dbReference type="EnsemblBacteria" id="AFZ55301">
        <property type="protein sequence ID" value="AFZ55301"/>
        <property type="gene ID" value="Cyan10605_3255"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3255"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3470"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745594_0_0_3"/>
    <dbReference type="OMA" id="TMQEPTI"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="41860" checksum="C1EF3CCCBF54BC92" modified="2013-03-06" version="1">MELINNLIKSWLTEENQAMMTKLSLEFGFFFLLIVLSFIAGRYTPNLCMLGISRISKQPLTQFYEKIIDPLKSIFRLTGTLILWSLSLNFIINYQGLYRVLNFVIDLSLILSMAWLASRLFRQIILIYGVDLIQKLGKEVDELLLVLETVINVIIGFVAAVAFAKRLEINLVGLLASLGLGGIAIAFAAQKTLEQLLGTCVLYLDRPFIVGEYIRLNNGLYGRVESIGLRSTKIRIPGKGTLMIVPNSMMANVEIENITRGKKVMVLLYLDFARILEDSEQALVEDIVKKCTNALFGIDPDSTKVALFIPEKQSQTRARVTFFILGSNESSIKLRKRLLELANENISAQLLTYGINFTMQEPTIYVESPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z2</accession>
    <name>K9Z7Z2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221029.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3265"/>
    <dbReference type="EnsemblBacteria" id="AFZ55311">
        <property type="protein sequence ID" value="AFZ55311"/>
        <property type="gene ID" value="Cyan10605_3265"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3265"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3480"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_3"/>
    <dbReference type="OMA" id="VWSNVFM"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="36053" checksum="7F57445DF2A6F165" modified="2013-03-06" version="1">MKAILMTEAGGVDVLQLRDIPTPQIKSPTEVIVELKAAGVNPIDTKIRKRGSFYPEFSSPVLGCDGAGIVVEVGDGVTRFRKGDEVYFCAGGLGKPETGNYAQYTVVEEDYVAKKPQSLSFAEAACAPLVLITAWEAMCDRISLGADDKILIHGGAGGVGHVAIQLAKLRGAEVATTVSNPDKERLVRKLGADYPILYKQKDFINAIMDWTKGKGVDAAFDTVGGKTFFDTCQAVKVYGDIVTILEPDCHSSSLKTARNRNLRISLELMLTPALMNLQEGLKHQRKILEQCAVWFDEGKLTIHLEHTFPLESASVAHQMIESGSTTGKIALTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z832</accession>
    <name>K9Z832_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55304">
        <property type="protein sequence ID" value="AFZ55304"/>
        <property type="gene ID" value="Cyan10605_3258"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3258"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3473"/>
    <dbReference type="HOGENOM" id="CLU_207600_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5506" checksum="6587995787994778" modified="2013-03-06" version="1">MNIMKMLENMTKYLTEGFARIFSPPEESPPEIGVQPFECAPYREKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z850</accession>
    <name>K9Z850_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221042.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3278"/>
    <dbReference type="EnsemblBacteria" id="AFZ55324">
        <property type="protein sequence ID" value="AFZ55324"/>
        <property type="gene ID" value="Cyan10605_3278"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3278"/>
    <dbReference type="HOGENOM" id="CLU_123783_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="19872" checksum="1C6A2ED5EB690C6F" modified="2013-03-06" version="1" precursor="true">MFIREGKLLTTYFFISFVGLGFIFAKSSQAQTAIFNFQTTIGGECAFSNIQGGSLQLSEDGKTFSSNVPATATLTCNLTNVSLTLNPPEVSTISAPFNIISSTATATYQENNPITYLLSGAVATGNIVTLEATNSSPDSRTYTGLTLGSSVLRIGGSRTITVNMSATSDTEVSAGLYRFIVRFSAIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z868</accession>
    <name>K9Z868_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily I DNA/RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220301.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2497"/>
    <dbReference type="REBASE" id="58395">
        <property type="entry name" value="Cap10605McrB3P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54578">
        <property type="protein sequence ID" value="AFZ54578"/>
        <property type="gene ID" value="Cyan10605_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2497"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2646"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007896_0_0_3"/>
    <dbReference type="OMA" id="MLENRLC"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="455"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="864"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1132" mass="129937" checksum="6D1CC56796CB0C90" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z875</accession>
    <name>K9Z875_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220306.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2502"/>
    <dbReference type="EnsemblBacteria" id="AFZ54583">
        <property type="protein sequence ID" value="AFZ54583"/>
        <property type="gene ID" value="Cyan10605_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2502"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2652"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_3"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="2"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="447" mass="49202" checksum="C9E4769EB00695BA" modified="2013-03-06" version="1">MPFAKILIANRGEIALRIIHSCEEMGIATVAVHSTIDRHALHVKLADESVCIGPPPSNKSYLNIPNIIAAALTRGAEAIHPGYGFLAENARFAQICADHNLQFIGPSPEAIIAMGDKSTAKKTMQEAGVPTIPGSKGLITDEEEAARVAAEIGYPVIIKATAGGGGRGMRFVSDETELSRLLRAAQGEAEAAFGNAGVYLEKFIELPRHIEFQILADSYGNVVHLGERDCSIQRRHQKLLEEAPSPALNPELRQKMGEAAVKAAKYINYVGAGTVEFLVDKYGNFYFMEMNTRIQVEHPVTEMITGLDLIKEQIAIAQGERLAFTQEQIQLKGHAIECRINAEDPDHDFRPNPGKIIAYLPPGGPGVRMDSFVYPDYEIPPYYDSLIGKLIVWGEDRETAIKRMKRALRECAITGVQTTINFHQKILNNPEFLAGNVYTNFIEQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z895</accession>
    <name>K9Z895_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221087.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3325"/>
    <dbReference type="EnsemblBacteria" id="AFZ55369">
        <property type="protein sequence ID" value="AFZ55369"/>
        <property type="gene ID" value="Cyan10605_3325"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3325"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3540"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126005_2_0_3"/>
    <dbReference type="OMA" id="PIPWEAQ"/>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7723" checksum="51CD74B32FA68AD8" modified="2013-03-06" version="1">MSYKDIITIQSGKRSGKPCIRGMRITVYDVLSYLASGMTYEEILNYFPYLTKEDILACLSYAADRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C6</accession>
    <name>K9Z8C6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221164.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3404"/>
    <dbReference type="EnsemblBacteria" id="AFZ55446">
        <property type="protein sequence ID" value="AFZ55446"/>
        <property type="gene ID" value="Cyan10605_3404"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3404"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3625"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_3_2_3"/>
    <dbReference type="OMA" id="NFVYVIP"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="504" mass="54381" checksum="FC839B23590CAE45" modified="2013-03-06" version="1" precursor="true">MTQNTSTNSSSLSSLIPILLGIFIGVLLGGFLPIWGQEVKFLGELFINALLMLVVPLVITSMIASITSLGDISKLKGIGLKTIIFYFITTGIAVILGLVLVNITQPGVAQTDAERVLLRGGEVLTNAEYKVEENEVLLLDTNLRKSFDDRYFVSLIDQDIKGNIIEKAPINSQKIIVSQWENSQGEIVSPLRRGRGINIDLTIAKRIEGKEKSSIKTTIEQVVTDLLPRNLFQSMVENDVLPLIIFSLVFGAILTTLEDGQIVIDFISVLNKAILKIVDLILIFAPIGIGALIAGRLGDAGGFEGFGSEFLSLWKYSSTVILGLILHGFFILTSILYLITSRSPFDYLRKTSPALITAFSTSSSSATIPVTLECAIKNNKVDSKIADFVIPLGATINMDGTALYEAVAAVFIAQIYGIELSLGQLIVIFLTATLAAVGAAGIPEAGLVTMVIVLKAVNIPVEGISLILVIDWFLDRCRTTINVWGDSVGAAVINHLNQENVNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J5</accession>
    <name>K9Z8J5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ordered locus">Cyan10605_2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220766.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2987"/>
    <dbReference type="EnsemblBacteria" id="AFZ55047">
        <property type="protein sequence ID" value="AFZ55047"/>
        <property type="gene ID" value="Cyan10605_2987"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2987"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3181"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_1_3_3"/>
    <dbReference type="OMA" id="TIQFPDP"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="24695" checksum="F4A46FE9BFF277CF" modified="2013-03-06" version="1">MARVRVRQHVNPLSSKYQQSISFPDWSQVYSNLSLPFYLDLGCARGRFLLQMAQQYPEKNYLGIEIREALVDEANEIKTDHNLTNLHYLFANINSSLEKLLTSLPPNSLELVMIQFPDPWFKKKHHKRRVVQPEIVEILAEFLRKDGRIFIQSDIKELAEEMCQIFLENPNFLSLSPNIWLLENPLGIMTEREIATLNKGENVYRAVMMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N0</accession>
    <name>K9Z8N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2396</name>
        <name evidence="2" type="ordered locus">Cyan10605_2884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220202.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2396"/>
    <dbReference type="EnsemblBacteria" id="AFZ54478">
        <property type="protein sequence ID" value="AFZ54478"/>
        <property type="gene ID" value="Cyan10605_2396"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54950">
        <property type="protein sequence ID" value="AFZ54950"/>
        <property type="gene ID" value="Cyan10605_2884"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2396"/>
    <dbReference type="KEGG" id="can:Cyan10605_2884"/>
    <dbReference type="HOGENOM" id="CLU_2552575_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9499" checksum="8D892A4FF905F3D8" modified="2013-03-06" version="1">MADFLGVNHQKIYAEISSWTLYKLQKVLKLLMVNVAVEQLQIIEKKSNSTQSRAKITLAVDDSVIDRVGKRLRRTFTWYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V4</accession>
    <name>K9Z8V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221304.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3556"/>
    <dbReference type="EnsemblBacteria" id="AFZ55589">
        <property type="protein sequence ID" value="AFZ55589"/>
        <property type="gene ID" value="Cyan10605_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3556"/>
    <dbReference type="HOGENOM" id="CLU_2896550_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7489" checksum="06F817C56F625258" modified="2013-03-06" version="1">MELNEIVKLINIRIGIINNTQKYIKQMNSDGWRDIIRENESRIQTLEQLKEDFVQKNNAHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X9</accession>
    <name>K9Z8X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220546.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2754"/>
    <dbReference type="EnsemblBacteria" id="AFZ54823">
        <property type="protein sequence ID" value="AFZ54823"/>
        <property type="gene ID" value="Cyan10605_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2754"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2924"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_3"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12473" checksum="9EA51B1098B2DB95" modified="2013-03-06" version="1">MAETIFSKIIRKEIPANIVYEDDLCLAFKDINPQAPTHILVIPKKPIVCIDDAQSEDQNLLGHLLLTVKKVAAEANLSNGYRVVINNGNDGGQTVDHLHLHILGDRAMQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z957</accession>
    <name>K9Z957_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ordered locus">Cyan10605_3210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220975.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3210"/>
    <dbReference type="EnsemblBacteria" id="AFZ55257">
        <property type="protein sequence ID" value="AFZ55257"/>
        <property type="gene ID" value="Cyan10605_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3210"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3422"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_3"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="166"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="242" mass="27463" checksum="55CF39B84BF37002" modified="2013-03-06" version="1">MKVIQDPRRKKDLRKLLQKLGLQDVSLVNWHLLDLALTHPSISPKDNYEQLEFVGDAVIRLSCAELLLETYPDLPVGDFAAIRSILVSDRFLAEIAEQYGLEMYLLASGGVRNDKWGKPSRLADCFEAVLGALYESTKDMSLIRPWLDPILQEKAIQVHADPARENYKDALQEWTQGKYKILPIYKVRQSESFVKENERFIAEVWLQDKLLGTGKGGTKKASQQAAAKQAYDSIMANELIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z972</accession>
    <name>K9Z972_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ54938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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        <property type="gene ID" value="Cyan10605_2872"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="YYLWGGT"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="91"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="27443" checksum="8C7C1A500FF2015B" modified="2013-03-06" version="1">MNSQLSDLLTPFPTGEYVCLTNLNLYAQPDCKELATQLRKGRYLKVLSSEIIDNTVKVCSLEDQYYAYLHITNLTELEIASQPYQPVSVTREKIETLISQVIEFTYQAMKTPNYYLWGGTVAPNYDCSGLMQSAFASVGVWLPRDSYQQEDFTTRISRDELQRGDLIFFGDARVNHVALYLGENKYIHSSGKEIGNDGIAINQLRDDLDQVSLNYYQKLWSYGRLDRSFIPDIQKLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z990</accession>
    <name>K9Z990_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221010.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3246"/>
    <dbReference type="EnsemblBacteria" id="AFZ55292">
        <property type="protein sequence ID" value="AFZ55292"/>
        <property type="gene ID" value="Cyan10605_3246"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3246"/>
    <dbReference type="eggNOG" id="COG2433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000099_0_0_3"/>
    <dbReference type="OMA" id="WYAIACK"/>
    <dbReference type="OrthoDB" id="2071575at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="32341" checksum="78334EB7B4556854" modified="2013-03-06" version="1">MTNSSSSSKPLINDVNWYAIASKIRNQNEKLKAKINDLENIIEEQKQQIKIQVIKNQDYSNLGENQQKQVENLKKQIVEKNQQIENQKEIIETLTEQLEKIQQQTARLERECSLLQDNYNDQQHQLKQVEKENKELKIRLQRQQRYNIQYKTALDQVIGASSADNNSLNINPLSNNDLSPITNHVSSNQFENKGENENSTPSTIDEKNRPIEKILNTPSFSQENTEVKQNTSLNLPLKNQDSNNNKEKTEDNKGRNQEKKQKKRGFIQLPQFGKKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C4</accession>
    <name>K9Z9C4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220712.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2931"/>
    <dbReference type="EnsemblBacteria" id="AFZ54993">
        <property type="protein sequence ID" value="AFZ54993"/>
        <property type="gene ID" value="Cyan10605_2931"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2931"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3119"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_3_3"/>
    <dbReference type="OMA" id="QRCNVVI"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="24442" checksum="E44200F5CF6FF388" modified="2013-03-06" version="1">MYILIGGVGMMGSDLARTLLQMGHTVAVVDTDTAACQYAREKIGVMAFEGSAVNTTVLLEAGIRKADAVIATLGEDALNLAMVTLSKYYGVTQIVVRMSDRDFTQPYKLAGATHIISTTELAINRIVNAIEYPQVDAMMHFEQGQIEVLKLSLPENCSVVGRKVAEIAQDEKFPMGTLIIGYQVNHHEPLSIPNGNTILEGGSTILAVTKPEFVRQLINFMGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N3</accession>
    <name>K9Z9N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221008.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3244"/>
    <dbReference type="EnsemblBacteria" id="AFZ55290">
        <property type="protein sequence ID" value="AFZ55290"/>
        <property type="gene ID" value="Cyan10605_3244"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3244"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3458"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_2_4_3"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="OrthoDB" id="1925503at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="11935" checksum="CF2957C78C4171C9" modified="2013-03-06" version="1" precursor="true">MPPFLITLIITAISMMITAYIIPGIVISNITAALLAALVFGIVNAIVKPILILFTLPVTILTLGLFLFVINAICFYLAAYFTPGLTINNFVDALLGSIVLSLISSFLNNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N7</accession>
    <name>K9Z9N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221155.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3395"/>
    <dbReference type="EnsemblBacteria" id="AFZ55437">
        <property type="protein sequence ID" value="AFZ55437"/>
        <property type="gene ID" value="Cyan10605_3395"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3395"/>
    <dbReference type="eggNOG" id="ENOG5033133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111019_0_0_3"/>
    <dbReference type="OMA" id="CFLGAYQ"/>
    <dbReference type="OrthoDB" id="1724197at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009560">
        <property type="entry name" value="DUF1176"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06674">
        <property type="entry name" value="DUF1176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="23041" checksum="0212CA91E9BD1FF8" modified="2013-03-06" version="1">MLYFQSLLNRFCSYVLILLLFSCQKETRENSELEAIIITPEEKQVIISKIYENQKDIKLCNQERDQALSIDSTEIYPLKENQYLVEILCFLGAYQGNYQYLLYNRVNSAIEKISFATFRDNPQNLQLTNTFTLNGSPEFDPISQTLSLETKSRGLGDCGSFVVYQWQNSEFTLREYRYKSDCDGVYLSPEKYPLIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Q4</accession>
    <name>K9Z9Q4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 metal ions per subunit. Manganese or magnesium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220827.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3051"/>
    <dbReference type="EnsemblBacteria" id="AFZ55108">
        <property type="protein sequence ID" value="AFZ55108"/>
        <property type="gene ID" value="Cyan10605_3051"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3051"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3249"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080985_1_0_3"/>
    <dbReference type="OMA" id="KWETKAW"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017290">
        <property type="entry name" value="RNase_H_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037839">
        <property type="entry name" value="Ribonuclease_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="106"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037839-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="24460" checksum="1EE4E74D55441B4C" modified="2013-03-06" version="1">MSKNNKKYYVVWQGRKTGIFNTWKECEQQVINFSGARYKSYKTLLEAESAFNSQGNTTVKSLQNSRNLNKLSQEKLTPSSIIIDSICVDASCLGNPGIVEYRGVDTKTHEEIFHKSPMNNGTNNLGEFLAIVHGLAYLKKQNKNIPIYSDSRTAISWVKNKKIKTTLIRNSSNEEIFNLVDRALEWLSNNSYPNKILKWNSKEWGEIPADFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R3</accession>
    <name>K9Z9R3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221180.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3422"/>
    <dbReference type="EnsemblBacteria" id="AFZ55462">
        <property type="protein sequence ID" value="AFZ55462"/>
        <property type="gene ID" value="Cyan10605_3422"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3422"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_3_2_3"/>
    <dbReference type="OMA" id="DEYILIM"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="137" mass="15744" checksum="AF9B688AC0B3AE17" modified="2013-03-06" version="1" precursor="true">MNKLRIILDTNILISGLLLSSSRVGEVFDIVTQNHILLISENTFTEFYLTITKRKFDKYLSFEKRIQFLGQLKAKALLINVIEIIDICRDSKDNKFLELAVSGKADFIVTGDNDLLVLNPFRDIEIITVSDFLNRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R6</accession>
    <name>K9Z9R6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221043.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55325">
        <property type="protein sequence ID" value="AFZ55325"/>
        <property type="gene ID" value="Cyan10605_3279"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3279"/>
    <dbReference type="HOGENOM" id="CLU_123783_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="123" mass="13166" checksum="A429EE259B1EC610" modified="2013-03-06" version="1">MQLSGDRKTFTSDNPATATLTCNRTSLDITLNPPEVSTNSAPFIIASSWATATYQENSPGNSPQPGNIITLTATNGSPASKTYGNNRRMEGSRDLTVNMSVTSDNEVSAGLYRFNVRFSATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V3</accession>
    <name>K9Z9V3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein Cyan10605_3320</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221083.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3320"/>
    <dbReference type="EnsemblBacteria" id="AFZ55365">
        <property type="protein sequence ID" value="AFZ55365"/>
        <property type="gene ID" value="Cyan10605_3320"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3320"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3534"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_1_0_3"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="247" mass="27444" checksum="8DBA3B6CBB991A40" modified="2013-03-06" version="1">MAGHSKWANIKRQKARVDAKKGKTFTQLSRAIIVAARNGLPDPDGNFQLRTAIEKAKSAGIPNENIERAIAKGAGTYNDDDSILEEIRYEGYGIGGVAVLIEALTDNRNRTAADIRAAFSKNGGNLGETGCVSWMFEQKGVIVIEGELEEDSLLEVCLNADAQSYEIIDEEDYQGAEIFTSVETLEQVNSFFQNQGFNVKETELRWIPNNYIEINDPEQTKFLLRLMDALESLDDVQNVTANFDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y5</accession>
    <name>K9Z9Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221118.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3358"/>
    <dbReference type="EnsemblBacteria" id="AFZ55400">
        <property type="protein sequence ID" value="AFZ55400"/>
        <property type="gene ID" value="Cyan10605_3358"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3358"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3576"/>
    <dbReference type="eggNOG" id="ENOG502ZNXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145470_1_1_3"/>
    <dbReference type="OMA" id="DLQYWQQ"/>
    <dbReference type="OrthoDB" id="1657186at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009666">
        <property type="entry name" value="Uncharacterised_Ycf35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39638">
        <property type="entry name" value="PTHR39638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06868">
        <property type="entry name" value="DUF1257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="127" mass="14582" checksum="0C0A2E0BAE80BA23" modified="2013-03-06" version="1">MSHFSSIKTQIRNLESLQASLNNLGIEWKNGPSTVRGYQGQTTQAQIVIEQENNYDIGFAWNGQEYELVADLQYWQQPWTVDGFLQRVTQGYALHTVLQESSKQGFSVTEQQKNNDGSIRLVVQRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAG4</accession>
    <name>K9ZAG4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221300.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3552"/>
    <dbReference type="EnsemblBacteria" id="AFZ55585">
        <property type="protein sequence ID" value="AFZ55585"/>
        <property type="gene ID" value="Cyan10605_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3552"/>
    <dbReference type="HOGENOM" id="CLU_2272713_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="12232" checksum="9D3896FF498068DA" modified="2013-03-06" version="1">MQLSLNLDPIIKTKSEFYKGWEIVANQRQKRQIIREGVTKLYQERYNQNWSEFKVYFYFETIIYRAGITRCICGENSGCQDFDIAIECTKKFIDHFYGYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0E3</accession>
    <name>K9Z0E3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="5" type="synonym">rps9</name>
        <name evidence="9" type="ordered locus">Cyan10605_0497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218370.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0497"/>
    <dbReference type="EnsemblBacteria" id="AFZ52639">
        <property type="protein sequence ID" value="AFZ52639"/>
        <property type="gene ID" value="Cyan10605_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0497"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.527"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_3"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="14623" checksum="F1FE547923F0C923" modified="2013-03-06" version="1">MSNQVVYLGTGRRKASVARVRLVPGTGAVKVNNREGSEYFQLIPNYIQTLKAPLETLGLENEYDIIVNAHGGGLTGQSDAVKLGVARALCQLDPDNRQPLKAEGYLTRDPRAKERKKYGLRKARKAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0G1</accession>
    <name>K9Z0G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="5" type="synonym">rpl29</name>
        <name evidence="6" type="ordered locus">Cyan10605_0517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218390.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0517"/>
    <dbReference type="EnsemblBacteria" id="AFZ52659">
        <property type="protein sequence ID" value="AFZ52659"/>
        <property type="gene ID" value="Cyan10605_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0517"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_0_0_3"/>
    <dbReference type="OMA" id="NTHRFKE"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="8866" checksum="DFA0A270F623D7BE" modified="2013-03-06" version="1">MAYRSIAEARNLSDEELTAEITSAKQKLFQLRLAQTTGRLEKPHEFKHTRRWVAQLLTIQTERQKGIVRKTTSNIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K4</accession>
    <name>K9Z0K4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phytyl-1,4-naphtoquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.329</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Demethylphylloquinone methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ordered locus">Cyan10605_0543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:40551"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28433"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:87844"/>
            <dbReference type="EC" id="2.1.1.329"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.329" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218415.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0543"/>
    <dbReference type="EnsemblBacteria" id="AFZ52684">
        <property type="protein sequence ID" value="AFZ52684"/>
        <property type="gene ID" value="Cyan10605_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0543"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.574"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_3"/>
    <dbReference type="OMA" id="WQKSALN"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00995"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052624">
        <property type="term" value="F:2-phytyl-1,4-naphthoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01982">
        <property type="entry name" value="MenG_phylloquinone_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032904">
        <property type="entry name" value="MenG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26615" checksum="BFA5C8B0B02D3EAA" modified="2013-03-06" version="1">MKSTPQPQEIQEMFNRIAPVYDSLNDWLSLGLHRIWKLMAVKWTNPQPQSVALDLCCGSGDLTFLLRQQVIKGRVIGVDFSSELLDVARVKAKNRGYDDIEWVKADVLSLPFQDNTFDCVTMGYGLRNVQDIPSCLREINRVLKPNGRAAILDFHQPSNYFVANIQKWYLDNIVVTMADWLGKKEDYAYIYPSLQRFLRGDRQIELARQIGFSQSVHYPLLGEMMGVLVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L3</accession>
    <name>K9Z0L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217994.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0103"/>
    <dbReference type="EnsemblBacteria" id="AFZ52262">
        <property type="protein sequence ID" value="AFZ52262"/>
        <property type="gene ID" value="Cyan10605_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0103"/>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061545_2_0_3"/>
    <dbReference type="OMA" id="FANADIW"/>
    <dbReference type="OrthoDB" id="1345387at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010328">
        <property type="entry name" value="DUF928"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06051">
        <property type="entry name" value="DUF928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="25569" checksum="CA299E58CCCCD5AC" modified="2013-03-06" version="1" precursor="true">MKNNNNPYFLRGISKLFVAVTSIMVILPVSVNALEFPSAPERNPPKSTAAGGRRGGCVQGDLPIKAITPGDDNKIKTISSQPPFYIYIPKTKADSAQFLIKSEDGTQLDFQEIAIENGDYIIEINLSDQINITEGQTYTWEISLVCNPMFINSGNYTKGTIERVSLDELTQTQLEMTGDTLDKAQIFANADIWTETLINVIAVKESQPQEWIELLTSVGLHDYAEKSFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T1</accession>
    <name>K9Z0T1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Cyan10605_0625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218495.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0625"/>
    <dbReference type="EnsemblBacteria" id="AFZ52764">
        <property type="protein sequence ID" value="AFZ52764"/>
        <property type="gene ID" value="Cyan10605_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0625"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.659"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_3"/>
    <dbReference type="OMA" id="LNEMCIK"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="34319" checksum="CE5572562BD7063C" modified="2013-03-06" version="1">MRLKQVIIAYKAEDKESKKWAERCAKELEARQCKVLLGPSGVKDNPYPVFLASTGQKIDLGIILGGDGTVLAAARHLSPESIPLLAVNVGGHLGFLTEPFELFKDTEKLWHRLENDLYAVERRMMLEAQVWEREKDNCEPVSDRFFCLNEMCVKPACLDRMPTSLLEMEVDGEVVDQYHGDGLIVSTPTGSTCYTASANGPIMHPGMSAIAVTPICPLSLSSRSLILPPRSVVSIWSLGDYELNNKLWTDGALATTMWPGQWVNVKMADCNAQFIILRDSHSFYKTLRDKLQWAGARIYYQNNHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V3</accession>
    <name>K9Z0V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Na-Ca exchanger/integrin-beta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218099.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0212"/>
    <dbReference type="EnsemblBacteria" id="AFZ52367">
        <property type="protein sequence ID" value="AFZ52367"/>
        <property type="gene ID" value="Cyan10605_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0212"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.222"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235149_0_0_3"/>
    <dbReference type="OMA" id="RENYPNF"/>
    <dbReference type="OrthoDB" id="37659at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0401">Integrin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="1548"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1933" mass="208510" checksum="488BE97FD361F4D2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y3</accession>
    <name>K9Z0Y3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218555.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0688"/>
    <dbReference type="EnsemblBacteria" id="AFZ52824">
        <property type="protein sequence ID" value="AFZ52824"/>
        <property type="gene ID" value="Cyan10605_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0688"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.722"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083159_2_1_3"/>
    <dbReference type="OMA" id="PVCRAGK"/>
    <dbReference type="OrthoDB" id="1918856at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="12302" checksum="CE673650AE8031FB" modified="2013-03-06" version="1">MSEAGKEKTLAEQAPPSYECRSCGYTYVPSKGDSKTNIPPGTLFTDLPSNWRCPVCGASRTVFVNVGAIDAPSGFAENLDYGFGVNRLTPGQKNLLIFSALALGVLFFLSLYGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z0</accession>
    <name>K9Z0Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217947.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0054"/>
    <dbReference type="EnsemblBacteria" id="AFZ52215">
        <property type="protein sequence ID" value="AFZ52215"/>
        <property type="gene ID" value="Cyan10605_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0054"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.56"/>
    <dbReference type="eggNOG" id="ENOG502Z7WZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304357_0_0_3"/>
    <dbReference type="OMA" id="QSWVTVE"/>
    <dbReference type="OrthoDB" id="1417642at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021751">
        <property type="entry name" value="DUF3318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11780">
        <property type="entry name" value="DUF3318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="26048" checksum="F4C5DADAB85012AA" modified="2013-03-06" version="1">MTSYTTSSARAEMNELRRLKTLLPPELQSWVMIEASTEVNPPLVRTEELGKDEVEIQIDLAKWENLAIDQRNLLFWHEVARIQNDTIPKEGWEMAALAIGLGGAVGELWVQDGLLLLLALALCGISGYRLWQKNNGEKNLKEAIEADEKAIQIATRFGYTLKNAYQSLGSAFKTLIEQTPNRSQRKKYEERLQALRRSAAKAKQQKTPEGGNQPLKTPSVRSRSSARMKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z149</accession>
    <name>K9Z149_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-Acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218620.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0756"/>
    <dbReference type="EnsemblBacteria" id="AFZ52889">
        <property type="protein sequence ID" value="AFZ52889"/>
        <property type="gene ID" value="Cyan10605_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0756"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.794"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_3"/>
    <dbReference type="OMA" id="RYNTERP"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="371" mass="41413" checksum="D4E94B4C1D40DEB1" modified="2013-03-06" version="1">MTFSKKTICITLGTRPEAIKLAPVIKCFQNTEDFDTKVILTGQHREMVAQVMDLFDLNADFDLDIMQTKQTLGDITCRSLQGLETIYQDIKPDLVITQGDTTTAFAASLAAFYQQISVGHVEAGLRTDNIYNPFPEEANRRLISQIAQLHFAPTTLAVENLHKSGVTGEIYHTGNTIIDALLSVAQKNPPCDVEGLDWNKYRVLLVTVHRRENWGEPLQDIISGLKLILAKFPDTAILLPLHRNPIVREPLQKQLGDHERVFLTEPLDYKELVGAIKRCFLLLTDSGGIQEEAPSLGKPVLVLRETTERPEAVIAGTAKLIGTKAEQILFSGSELLDSENNYRQMAEAINPFGDGKASQRILDIVRKYFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A0</accession>
    <name>K9Z1A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transposase IS891/IS1136/IS1341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_0849</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218712.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0849"/>
    <dbReference type="EnsemblBacteria" id="AFZ52981">
        <property type="protein sequence ID" value="AFZ52981"/>
        <property type="gene ID" value="Cyan10605_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0849"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.892"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="SEYIMSA"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="189"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="222"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="428" mass="50061" checksum="3DD33DBFC38AC2EA" modified="2013-03-06" version="1">MLTLNYTYRIYPDGKQSAQLGNWLETCRCTYNYALQELKDWIKSRKTPVDRCSLESEYIMPANYPFPSYHQQQNNLPKAKKIFPRLKEVPSQVLQTTIRRLHDGWDFFQKRGYGFPRFKKYGQMKSLLFPQFKTNPITGWQIKLPKLGDVVINLHRPIPEGFVVKQVRVIKKAKGWYAVIVLQSDISIPDQVPHGHCIGVDVGLLSYMSTSDGFVEPRPKFLKELYRRLKVLQHRLSKKQKRSKNYEKLRKQIEALHNHIAFKRKDYQFKLCHKLCDMADSIFLEDCDFRIMAKGMLSKHTLDASFGQFRSILKYVGKRRGVFVDEVDHRGTSQTCPNCRTEVRKELSERWHSCSECNYKCDRDIASAQEICNRGIEKYSTQGLWGKEIGYQVGLSGAMCLDKWRSDGSLRRRKTQGKVHQERIANSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I1</accession>
    <name>K9Z1I1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyQ</name>
        <name evidence="9" type="ordered locus">Cyan10605_0894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218755.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0894"/>
    <dbReference type="EnsemblBacteria" id="AFZ53024">
        <property type="protein sequence ID" value="AFZ53024"/>
        <property type="gene ID" value="Cyan10605_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0894"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.939"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_3"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="35111" checksum="4C7710E7AC2A0A34" modified="2013-03-06" version="1">MTINFQDIVATLNQFWSERNCLIAQPYDTEKGAGTMSHNTFLRAIGPEPWSVAYIEPCRRPTDGRYGENPNRVQHYYQYQVLIKPSPDNIQEIYLDSLKALGIHPEDHDIRFVEDNWESPTLGAWGVGWEVWLDGMEITQFTYFQQCGGIDCKPVSIEITYGLERLAMYLQDVDSIYDIQWNNEIKYGDIFLQGEIEQCTYNFEASNPDLLFQLFTLYEEEAKQLIEKNLVLPSLDYVLKCSHCFNLLDARGVIAVAERTRYIGRIRHLARQVAEQYLAQRESLNFPLNKQAKTEKKQLVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L9</accession>
    <name>K9Z1L9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CTD-binding SR-like protein rA9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218790.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53059">
        <property type="protein sequence ID" value="AFZ53059"/>
        <property type="gene ID" value="Cyan10605_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0929"/>
    <dbReference type="eggNOG" id="ENOG502ZG6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802914_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16555" checksum="2B90BC45F563F1D8" modified="2013-03-06" version="1" precursor="true">MKKLSNLLWFSGLLGLVTLGLGATMSESLAQIRGEDSDRFFRQGNEMMEEQIREIQRESVRQQQEEKAQMGDMDDMDMNDMDMENPENMDGFEEDRDEKETELETELEMKQPSGVELKEVEENPEGLDDNVPESPENEIEVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M7</accession>
    <name>K9Z1M7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with the myosin-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217990.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0099"/>
    <dbReference type="EnsemblBacteria" id="AFZ52258">
        <property type="protein sequence ID" value="AFZ52258"/>
        <property type="gene ID" value="Cyan10605_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0099"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.102"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033222_0_0_3"/>
    <dbReference type="OMA" id="GNYVRGE"/>
    <dbReference type="OrthoDB" id="1465714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021435">
        <property type="entry name" value="DUF3084"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11283">
        <property type="entry name" value="DUF3084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="54970" checksum="C16CE36E4FA1986A" modified="2013-03-06" version="1" precursor="true">MTSAYILIIAMLLLGGLIAALGDRIGTRVGKARLRLFQLRPKQTAVLITIGTGTLISASTLIILFSLSASLRQGVFQLDEILKKRREITQQLDTVKAEKERVEEALLEAKNRQNTVLNQLNVKENELSTTQKKVREIQSRTEKLRKEVERIIKEKEDLLIEKDEIQQQSLKLEQSIAQRDQELREKQGQIEQQEAILQQQQISLEQLKNRQKQLESEISSRDEQIVELDRLISQTDDILDAKERELASLEGQLEFYRQEVEILEQYYQTYQDLRERPIAVIKGQVLSVTLVQIKKDTDISELVDAILSQANRNVMQIIGYGNQPPKERFVQITRGQVEQMKQQLANPGQYLVRILSAGNYVQGEERIRIFGDVTPNQIIYQKNEAIASISIDEQDLNSGELQEKLDFLISVSQFRARREGILGQIFIGDGKITSLVNFIEELQSSDQTIDEILTVAASETYTSGPLQINLVVIADGKEVFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q6</accession>
    <name>K9Z1Q6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="3" type="synonym">rpl14</name>
        <name evidence="6" type="ordered locus">Cyan10605_0515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218388.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0515"/>
    <dbReference type="EnsemblBacteria" id="AFZ52657">
        <property type="protein sequence ID" value="AFZ52657"/>
        <property type="gene ID" value="Cyan10605_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0515"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.545"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_3"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13427" checksum="4A47C70C7D8176E4" modified="2013-03-06" version="1">MIQQQSYLNVADNSGARKIMCLRVLSTGNCTYGGIGDVIIAVVKDAIPNMAVKKSDIVRAVIVRTKHSLRRESGMSIRFDDNAAVIINKDNNPRGTRVFGPVARELRDKNFTKIISLAPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S1</accession>
    <name>K9Z1S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218882.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1025"/>
    <dbReference type="EnsemblBacteria" id="AFZ53151">
        <property type="protein sequence ID" value="AFZ53151"/>
        <property type="gene ID" value="Cyan10605_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1025"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1086"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_2_1_3"/>
    <dbReference type="OMA" id="KKYHWDV"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="176" mass="20602" checksum="49E004AA9A3BB5D4" modified="2013-03-06" version="1">MNTINIGLSKTEIQEVVKLLNQNLADFYLLQIKTKKYHWDVVGPQFLTLHEIWQGQYEIISDNIDNCAERIRALGEYPIGTAQLFLENTTLKEHPSDLPDSTEMVQRLVIDHEHIIRNLRKHIDLCSQKFHDEGTADFLTGIMEQHEEMAWMLRSFIGGKNIEQRIREDRELITES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V9</accession>
    <name>K9Z1V9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218306.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0431"/>
    <dbReference type="EnsemblBacteria" id="AFZ52575">
        <property type="protein sequence ID" value="AFZ52575"/>
        <property type="gene ID" value="Cyan10605_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0431"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.454"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_6_2_3"/>
    <dbReference type="OMA" id="YEEAPCA"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21934" checksum="26A9A9CBDFC2B6D5" modified="2013-03-06" version="1">MVAIQETIKGSNLSPEEYLTQEEKALTKHEYINGEVYEMAGASSAHVTISLNVASLLKAHLKGSNCRVFISDMKVRIDRLNVFYYPDVIVTCNEKDRELNYYKKAPQIIIEVLSESTESFDRGDKFADYRTIETLQEYVLISQTKKRVDLFTRKNCNSWELSSFSEGEKLTLNSINFTCSVLDLYEDIDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W6</accession>
    <name>K9Z1W6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="13">ATP-PRT</shortName>
            <shortName evidence="13">ATP-PRTase</shortName>
            <ecNumber evidence="5 13">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hisG</name>
        <name evidence="15" type="ordered locus">Cyan10605_0561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218433.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0561"/>
    <dbReference type="EnsemblBacteria" id="AFZ52702">
        <property type="protein sequence ID" value="AFZ52702"/>
        <property type="gene ID" value="Cyan10605_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0561"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.592"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_3"/>
    <dbReference type="OMA" id="VASKFVH"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="14">
        <location>
            <begin position="52"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="22873" checksum="61A1903C728ABBB1" modified="2013-03-06" version="1">MLTIALPKGALLKDSIKLCQQAGLDFSLFLEESNRQLQIEDPQGLAKALLVRAQDVPVYVEYGQAHLGIVGYDVLKEKQADVAQIADLGFGYCRMSVAVPSASSYRSSSDLPAHGIVASKFVNCAKEHFRALDLPVEIVPLYGSVELGPITGMSEAIVDLVSTGKTLRENGLIEIDILFESSAYLVANPLTYRLNSYQLSEWVKKIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X9</accession>
    <name>K9Z1X9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">Cyan10605_0577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0577"/>
    <dbReference type="EnsemblBacteria" id="AFZ52717">
        <property type="protein sequence ID" value="AFZ52717"/>
        <property type="gene ID" value="Cyan10605_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0577"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.609"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041534_0_0_3"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="77"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="331"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="461" mass="51259" checksum="92828FDB927B470F" modified="2013-03-06" version="1">MAQFVIAHKLTHLIIGMNIVERLRLGLAVATAKIVTGLVKTFKLGAASVLPGEISRRLYPRLLQLLSQQFRGGLILVVGTNGKTTTSLLLKDILVHKGYKVIHNSTGANLINGLITCLVTNSNLWGILSADYGILEVDENVLPLVLKECQPSHILALNLFRDQLDRYGEVDTISYRWQNAITPLNKDTYIIINGDDPTLCYLGQNLPQKVCYFGLNEPELYLDEIPHAVDSIYCPKCGTSLQYKGVYISHLGDYDCPSCDFTKSKLSVNSKEWPQILIGVYNKYNTLAAGLTAETIGIERDIINDTIHNFKAAFGRAEELTIQDKNIRILLSKNPVGMNETIRAVNDIREINPQSTILMVLNDRTPDGTDVSWIWDVDTEKLVAGGGNIVVSGDRLYDMALRLKYSLDTLNSNLNLIIEEKLSQAINKALELTAVGETLYIIPTYSAMLEVRKILLGREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y4</accession>
    <name>K9Z1Y4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218130.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0247"/>
    <dbReference type="EnsemblBacteria" id="AFZ52398">
        <property type="protein sequence ID" value="AFZ52398"/>
        <property type="gene ID" value="Cyan10605_0247"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0247"/>
    <dbReference type="eggNOG" id="ENOG502ZIHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2731110_0_0_3"/>
    <dbReference type="OrthoDB" id="2085911at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="71" mass="8336" checksum="DF5F6F60AC80AB2C" modified="2013-03-06" version="1">MSIKGLINQKIENLSESEQMKVLNLIDIIQQENLKTENQLWSQFSLEQAMKGLENDLIPEYTEADLIEKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z238</accession>
    <name>K9Z238_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophycocyanin alpha-B subunit apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218190.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0310"/>
    <dbReference type="EnsemblBacteria" id="AFZ52458">
        <property type="protein sequence ID" value="AFZ52458"/>
        <property type="gene ID" value="Cyan10605_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0310"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.322"/>
    <dbReference type="eggNOG" id="ENOG502Z81S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="LIGVREM"/>
    <dbReference type="OrthoDB" id="1326472at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3 4" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2 4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="17961" checksum="E38CD56BC2595957" modified="2013-03-06" version="1">MSIVSQVILKADDELRYPSSGELQGIKSFLETGLLRVKIAETLSENEKKIVEKASQELFKKRPDFRAPGGNAAGQKQYNQCIRDFGWYLRLATYGVLAGDKEPIEKIGLIGAKEMYNSLGVPLPGMVESIRCLKTAALALLSKEEAEETAPYFDYMIQYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z271</accession>
    <name>K9Z271_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Cytochrome b559 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">PSII reaction center subunit VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psbF</name>
        <name evidence="16" type="ordered locus">Cyan10605_0691</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="13">With its partner (PsbE) binds heme. PSII binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Heterodimer of an alpha subunit and a beta subunit. Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13 14">Cellular thylakoid membrane</location>
            <topology evidence="13 14">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the PsbE/PsbF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218558.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0691"/>
    <dbReference type="EnsemblBacteria" id="AFZ52827">
        <property type="protein sequence ID" value="AFZ52827"/>
        <property type="gene ID" value="Cyan10605_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0691"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.725"/>
    <dbReference type="eggNOG" id="ENOG50332KX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211753_1_0_3"/>
    <dbReference type="OrthoDB" id="2060731at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00643">
        <property type="entry name" value="PSII_PsbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006241">
        <property type="entry name" value="PSII_cyt_b559_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006216">
        <property type="entry name" value="PSII_cyt_b559_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013081">
        <property type="entry name" value="PSII_cyt_b559_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33391:SF14">
        <property type="entry name" value="PTHR33391:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00283">
        <property type="entry name" value="Cytochrom_B559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000037">
        <property type="entry name" value="PsbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01333">
        <property type="entry name" value="cyt_b559_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00537">
        <property type="entry name" value="CYTOCHROME_B559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_B559" evidence="15">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with alpha subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="44" mass="4965" checksum="C2644B63F330342A" modified="2013-03-06" version="1">MTSNNPNQPVSYPIFTVRWLAVHTLAVPSVFFIGAITAMQFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z288</accession>
    <name>K9Z288_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218239.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0363"/>
    <dbReference type="EnsemblBacteria" id="AFZ52508">
        <property type="protein sequence ID" value="AFZ52508"/>
        <property type="gene ID" value="Cyan10605_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0363"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.382"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="ALPREEC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16383">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008629">
        <property type="entry name" value="GUN4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037215">
        <property type="entry name" value="GUN4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05419">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140869">
        <property type="entry name" value="SSF140869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="547" mass="62718" checksum="A113928D14969DF3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G9</accession>
    <name>K9Z2G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Cas6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219073.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1225"/>
    <dbReference type="EnsemblBacteria" id="AFZ53344">
        <property type="protein sequence ID" value="AFZ53344"/>
        <property type="gene ID" value="Cyan10605_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1225"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1293"/>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093259_0_0_3"/>
    <dbReference type="OMA" id="LMFRSWL"/>
    <dbReference type="OrthoDB" id="1403079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="133"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="28988" checksum="17366A1F3E2CCD6B" modified="2013-03-06" version="1">MLIKSTWTLTVNEITLLPCSYTVFLIKNLYQKMSLDFINNPIPEITFSGIIGNCKKEGNFYILFPDEKYYLSLSGLEFNASNAIQNLKFNSSLDFLGIQLDVINRENKITSYEEIYSKLVANDPHSIREYTINFLTPTAFAQGKINLPLPIPSLMFRSWLDKWNYFCNIYLGGDELTQYLSENIYFNYYKLYSRQQYIGQQKKTGFIGEVKLKIPLKVDTLLINVVNLLMNYSNYCGTGIKTRLGMGNTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I4</accession>
    <name>K9Z2I4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c biogenesis protein CcsB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccsB</name>
        <name evidence="6" type="synonym">ccs1</name>
        <name evidence="9" type="ordered locus">Cyan10605_0636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">May interact with CcsA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Ccs1/CcsB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218506.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0636"/>
    <dbReference type="EnsemblBacteria" id="AFZ52775">
        <property type="protein sequence ID" value="AFZ52775"/>
        <property type="gene ID" value="Cyan10605_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0636"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.672"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034630_0_0_3"/>
    <dbReference type="OMA" id="RFWIDYT"/>
    <dbReference type="OrthoDB" id="1518243at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01392">
        <property type="entry name" value="CytC_Ccs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="445" mass="50356" checksum="1E7745AA6433FB71" modified="2013-03-06" version="1">MSVSNYNNLSIKGKFDLYFRRLISTIADLRLAIILLLVIAIFSITGTIIEQNQPINYYQENYPENPALFGFLTWQVLLNIGLNHVYTTWWYLAILFLFGSSLIACTFRRQLPALKSAKIWSFYHQSRQFNKLAFSAEITTESLNIIESILNKKGYKVFSSDNSIYAQKGIAGRVGPIIVHIGMIIILLGAIWGAFSGFFAQEMIASGNTFMIKNYLEAGKLTNLEKAQSFQVKVNDFWIDYTPEGKVDQFYSDLSVINKQGEEVKRKTIFVNQPLRYKGITFYQTSWSISGVKVQLNNSPIFQLPMAELATENQGRIWGTWIPTKPDLSEGVSLITKDLQGTMFLYNMQGELINAIRPNMPVEVNGVNLKVLQLVGATGLQIKSDPGVPIVYFGFALLMIGVVMSYVSFSQVWALQEGNRFFIGGKTNRAQVAFEKEMYNILEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J9</accession>
    <name>K9Z2J9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase/vanadium-dependent haloperoxidase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219155.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1311"/>
    <dbReference type="EnsemblBacteria" id="AFZ53426">
        <property type="protein sequence ID" value="AFZ53426"/>
        <property type="gene ID" value="Cyan10605_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1311"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1384"/>
    <dbReference type="eggNOG" id="COG1963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073969_1_1_3"/>
    <dbReference type="OMA" id="QPIEVFF"/>
    <dbReference type="OrthoDB" id="1864362at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="16636" checksum="976E4668C82A20C0" modified="2013-03-06" version="1">MEVLRDIFSNKLLVIPLLACFLAQIIKVSVDTIANQKFSFRYIVSTGGMPSAHSALVGALATGTGQILGWSSPEFAIATIFAVIVMYDAAGVRQAAGKQARILNQIMDEFLRHEDFNEERLKELLGHTPFQVLVGLLLGILSSLFLLPLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S8</accession>
    <name>K9Z2S8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coproporphyrin ferrochelatase</fullName>
            <ecNumber evidence="2">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0747"/>
    <dbReference type="EnsemblBacteria" id="AFZ52880">
        <property type="protein sequence ID" value="AFZ52880"/>
        <property type="gene ID" value="Cyan10605_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0747"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.784"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815756_0_0_3"/>
    <dbReference type="OMA" id="MNHGCPH"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="43901" checksum="B3E7AE8DF26153F0" modified="2013-03-06" version="1">MVVTPEKTIESNSVSPATDRVAIILMGYGEVESYDDFANYNEQALNLLTAKFAPVPTWLYPPLAKLLAVFDLHEWSHQHGNFVSPHNAIFERQRAKIEHQLQHTWGEKVKVFKAFNFCKPHLPYQVLEQVKAEGFEKILIYPLLVVDSIFTSGIAIEQINEALAQKDKKEDHWVKALRYIPSFYNKPEYIDLLAKLVEEEIDAKLSNAYLPSEIGIVLMNHGCPHEAKGFTSGIDESQALYELVREKLIYRYPLISVGWLNHQTPLIKWTQPNAELAGRNLIELGAKALIFMPIGFATENHETLLDVEHIIQALYVKYPDVNYVQMECVNDNEEFCAMAAQWVNPLIESLLTEEGAVINPSFAKTHYHGHHHHDHNHNHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T6</accession>
    <name>K9Z2T6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ordered locus">Cyan10605_0757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218621.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0757"/>
    <dbReference type="EnsemblBacteria" id="AFZ52890">
        <property type="protein sequence ID" value="AFZ52890"/>
        <property type="gene ID" value="Cyan10605_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0757"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.795"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_3"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="180"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="281"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="51196" checksum="3CC4AD33C5EF8438" modified="2013-03-06" version="1">MVVSFSRPQGEVKNSHFQALPVKLFGTDGIRGKVGDLLTANLALEVGLAAGKVLQDYHSTSGVVIIGQDSRNSSDMLSMAIASGLTSMGLEVWNVGLCPTPCVAYLAKTTEAIGGVMISASHNPPQDNGIKFFGEKGTKLDTILTGAIEKTIRQHVSGDINLQGGKCGHIRQYHDLTKNYASFLENSIPNHLDFSGIKIVLDLAWGASVELAPLMFKALGAEVICLNSQADGDRINVDCGSTHLEQLKQAVKDHQADIGYAFDGDADRVMAVDSQGRVVCGDYILYLWGKYLQNKGLLPNNLLIGTVMANLGFEMAWQKLGGKLTRTAVGDQNVQAAMWETGAMLGGEQSGHILCHHHHFSGDGIQTALQLTALVRQEGNCLKSLINDSFTPYPQVLKNVRVEDREKRLNWQDNDTIQSAIASAESAMGNQGRVLVRASGTEPLIRVMVEAQNCDLVNYWTNHLVKVVEDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X8</accession>
    <name>K9Z2X8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52703.1"/>
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            <dbReference type="EMBL" id="AFZ52703.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
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    <sequence length="596" mass="66668" checksum="29335DF16CDEC95C" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
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        <name evidence="2" type="ordered locus">Cyan10605_0952</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="24992" checksum="7B0031133EC433F0" modified="2013-03-06" version="1">MLVNLSNQIGSILLITVYIGGLLLIAEILNRLHKTDSELTRKIVHIGTGNVILLAWWLNITSDVILLAVITASIVAIASYYLPILPSVNSVGRHSLGTLFYAISIGILTALFWHEGEKQFTAIGILIMSYGDGMAALIGQKWGKHKYQLLGNKKSWEGSLTMTLVSILVVISIFGIVATIQTKLFIIALLIGIFATILETFSSFGIDNLTVPVICGILAYYLQNIFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z1</accession>
    <name>K9Z2Z1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GHMP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFZ52713"/>
        <property type="gene ID" value="Cyan10605_0572"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.603"/>
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    </dbReference>
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    <dbReference type="OMA" id="LEIHHDG"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55060"/>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="4">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="5">
        <location>
            <begin position="237"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36306" checksum="FAB5A54A478DD1EE" modified="2013-03-06" version="1">MLISRSPVRISFFGGGTDYPEYFLRHGGAVLATAIDKFCYLTASPFPSQLFDYKIRLSYRQVELVKNVEQIQHNVYRECLKFCGLEGDIELHNVADLPAFTGLGSSSTFTVALLQALHSFKGEFVRPLDLAYEAIYVERQLLKDKVGCQDQLMAAVGGFNLVEFRTETDILVHKVPISPQRLAEFEKHLFIVFTGIKRRAAQVVAHQLEKVVDNTDTLKMMRLMVDEGWDILTSNKPFSAFGELLHKAWMAKRSLASAISNPQIDEIYSLGIDAGAWGGKLLGAGAGGFILFFAPPEVHPALKSVFGDRQVLDIKVNAPGSEIIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z339</accession>
    <name>K9Z339_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218504.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0634"/>
    <dbReference type="EnsemblBacteria" id="AFZ52773">
        <property type="protein sequence ID" value="AFZ52773"/>
        <property type="gene ID" value="Cyan10605_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0634"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.670"/>
    <dbReference type="eggNOG" id="ENOG5031X2B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110216_0_0_3"/>
    <dbReference type="OMA" id="PTIGQYD"/>
    <dbReference type="OrthoDB" id="1536718at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021469">
        <property type="entry name" value="DUF3122"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11320">
        <property type="entry name" value="DUF3122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="163" mass="18793" checksum="E045C7B38520D060" modified="2013-03-06" version="1" precursor="true">MLYFWQKLTSTLVIIFICLLGLCFFPHETFALTRQIEEAPQQFLTQSRHTLRDNQGNSWQVVFFQRKKNGEVKTVDLRLVAFPDVVTFKHPQPLKITFNQGKILFAEDKFAEQSPAPNVGEYDFMPIISQLSPTDYIELSLPDDLSLTIPAAIIVEWRSLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A7</accession>
    <name>K9Z3A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218589.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0723"/>
    <dbReference type="EnsemblBacteria" id="AFZ52858">
        <property type="protein sequence ID" value="AFZ52858"/>
        <property type="gene ID" value="Cyan10605_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0723"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.758"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="DPINFRV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="14344" checksum="394C8DD20B5EE2CC" modified="2013-03-06" version="1">MSTILIVEDDPINMKVFSKILVKRGGFEVKGTENVDEVILMAKEGIPDVILMDVSLANSFYQGKAVDGIKITQILKQDSNTKHIPVILVTAHAMQGDKESFLAESGADGYISKPVVDHQDFVDRIKAVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B5</accession>
    <name>K9Z3B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218599.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0734"/>
    <dbReference type="EnsemblBacteria" id="AFZ52868">
        <property type="protein sequence ID" value="AFZ52868"/>
        <property type="gene ID" value="Cyan10605_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0734"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.770"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_3_1_3"/>
    <dbReference type="OMA" id="YLMTTYQ"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="157" mass="18070" checksum="F2F945B06D1A4997" modified="2013-03-06" version="1">MNCSHIEFCTDKTKIDLVQLQDLYKVTAFWAKNRSLSDIKIAITHSNPVVSVWDRQRLIGSARATSDGIYRATIWDVVIHPDYQGLGLGRKLVETIISHPLLNRVERVYLTTTHQQKFYQKIGFQENSTTTMVLYNRYPTPNELVKQSQSEEITAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H6</accession>
    <name>K9Z3H6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218876.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1019"/>
    <dbReference type="EnsemblBacteria" id="AFZ53145">
        <property type="protein sequence ID" value="AFZ53145"/>
        <property type="gene ID" value="Cyan10605_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1019"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1080"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_2_2_3"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="18750" checksum="853013561186A1AA" modified="2013-03-06" version="1">MIEMKVAAIALDAISRSPIILLKDATERRALPIYIGQDQARSIIGALEQQVSPRPLTHDLIVNILSAWNLRLDRIIINALEDNTFYALLCLKGGELEQQIDCRPSDAIALALRAGCPIWVMEEVILDASIPVDRDADEEEREAFRDFVSNLSPEELIRRARKSNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I5</accession>
    <name>K9Z3I5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proton extrusion protein PcxA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pcxA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in light-induced Na(+)-dependent proton extrusion. Also seems to be involved in CO(2) transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219411.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1575"/>
    <dbReference type="EnsemblBacteria" id="AFZ53684">
        <property type="protein sequence ID" value="AFZ53684"/>
        <property type="gene ID" value="Cyan10605_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1575"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1672"/>
    <dbReference type="eggNOG" id="ENOG502Z8DN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690401_0_0_3"/>
    <dbReference type="OMA" id="PANRDFI"/>
    <dbReference type="OrthoDB" id="1605855at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01308">
        <property type="entry name" value="CemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004282">
        <property type="entry name" value="CemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33650">
        <property type="entry name" value="PTHR33650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03040">
        <property type="entry name" value="CemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="52159" checksum="752CE37A9E959A19" modified="2013-03-06" version="1">MFNRLFRSTKRWISNSLENALEEAYQRALTIKKIEDEHFKGQKISFQNCDYGESVWAYFQSELKSNLRVIKVKINQFKTNKSIHTFLSSKSKNSHYNYNHSGDYNFEYEQEIILEKLNFIDQILDKYNADYYETSSVKIDSNSPNQNINNNPSLAKQKNIQKQDKNDNNFESSLETVSDKTSVLPRSFLRTIDRIKQEIDPKSSESEQDVLNRFRKSKYKTAISIKFLLLLIIVPLLVHNVAKIALGKVFIDPYFSRHEEIVFINQDLQEEALIELKNFEENLNLKVMLGIIPELSIEEKEHEIKAKAQELGEEYRRESANAIKNIFADVFSLIAFGIVIYFSKRELQILKSFIDETIYGLSDSAKAFLIILFTDMFVGFHSPHGWEVILESISRHFGLPENRDFNFLFIATFPVILDTVLKYWIFRYLNRISPSAVATYKNMNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S2</accession>
    <name>K9Z3S2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxybenzoate solanesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-HB polyprenyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">plqA</name>
        <name evidence="8" type="ordered locus">Cyan10605_1749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219578.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1749"/>
    <dbReference type="EnsemblBacteria" id="AFZ53851">
        <property type="protein sequence ID" value="AFZ53851"/>
        <property type="gene ID" value="Cyan10605_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1749"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1856"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_1_1_3"/>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002083">
        <property type="term" value="F:4-hydroxybenzoate decaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047293">
        <property type="term" value="F:4-hydroxybenzoate nonaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010236">
        <property type="term" value="P:plastoquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="31985" checksum="EBF8E6A5BB710D10" modified="2013-03-06" version="1">MVSSPELKSSSLVENIVKLLRWDKPAGRLILMIPALWALFLAGEGKPPLPLVGVVILGSLATSAAGCVINDLWDRNLDNQVERTKTRPLASRALSVRVGIVVFFISLACAAVLAFYLNALSFWLCVGAVPFIVCYPLAKRVFPVPQLVLSLAWGFAVLISWSAVTGNLNNNTWLLWGATVTWTMGFDTVYAMSDKEDDLKVGINSSAIFFDDLVGDAVGLFYALTAGLFAYIAMVNGFNLFFGVAWAIAVILWVGQYIQIRGINQDSINYGQIFSQNVWIGFILLLGIILGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W5</accession>
    <name>K9Z3W5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219166.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1322"/>
    <dbReference type="EnsemblBacteria" id="AFZ53437">
        <property type="protein sequence ID" value="AFZ53437"/>
        <property type="gene ID" value="Cyan10605_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1322"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1396"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_3"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="640" mass="69665" checksum="5B2E4E74D182C89D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z401</accession>
    <name>K9Z401_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219201.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1358"/>
    <dbReference type="EnsemblBacteria" id="AFZ53472">
        <property type="protein sequence ID" value="AFZ53472"/>
        <property type="gene ID" value="Cyan10605_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1358"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1432"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021297_0_0_3"/>
    <dbReference type="OMA" id="QMGPHLH"/>
    <dbReference type="OrthoDB" id="1489393at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046133">
        <property type="entry name" value="DUF6130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19625">
        <property type="entry name" value="DUF6130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="422" mass="48022" checksum="EE25AD44E986D533" modified="2013-03-06" version="1" precursor="true">MMSRIKILSWLTVIFFCWTLLGCSDTIESVQAFNSESKSPIPRVENISEVAPPKLIQELNKNFSQTKPEVKILSPQIDEIVNSQDVSVSLQVKGLDIFKDEELGMGPHLHFFLDDKPYQAIYSASEPIILEGLAPGTHTIRVFASRPWHESFKNPTAYAQTTFHVFTATEDNNPSQDEPLLTYSRPQGTYGAEPIMLDFYLTNAPLHVVAQENPADDIADWRIRVTINGESFLLDTWQPIYLTGFNKGQNWVKLEYIDENGNVIQNAFNSTVRAINYDPSLQDTLAKLVTDKISLDKVKAIALKDYQGLQEVKTQEKEEIIEEELSEEVEEVKEEKSEILEEELTPEVIEEELVEDVTDIAEPSVNESKPENMKVEQDKDILPQEIEPTADLTEEQNEQENISEELETKENKQEDVNDSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z440</accession>
    <name>K9Z440_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219688.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1860"/>
    <dbReference type="EnsemblBacteria" id="AFZ53961">
        <property type="protein sequence ID" value="AFZ53961"/>
        <property type="gene ID" value="Cyan10605_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1860"/>
    <dbReference type="eggNOG" id="ENOG5033QG2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657921_0_0_3"/>
    <dbReference type="OrthoDB" id="2115906at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="18540" checksum="5182A1801E1C9839" modified="2013-03-06" version="1">MDTWKQLKSTYRKAYHQITTEKPHEDEQKYKTFASCVAILCHDNVKYSLRDRLSYLTKLLDLSGGPTVREHACIQSAYAIGDAVEIKHHGMTSYALDERFPLPGTWDYQKAYNFSIPHIFGKIMPIHIKVWLEENCFDDSPEDILEIQTLLETSSDYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z449</accession>
    <name>K9Z449_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="16" type="ordered locus">Cyan10605_1027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218884.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1027"/>
    <dbReference type="EnsemblBacteria" id="AFZ53153">
        <property type="protein sequence ID" value="AFZ53153"/>
        <property type="gene ID" value="Cyan10605_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1027"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1088"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_3"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="15">
        <location>
            <begin position="114"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="37358" checksum="4BEADDAD3120D101" modified="2013-03-06" version="1">MITDIESRLKTLAQEAQEAIASSESLSQLEELRVSYLGKKGQLSLILKEMGKLSAEERPRIGAIANEIKTTIQDNLSNKQQNLQQAEIEKQILAETLDVTMPGVSYPLGKSHPLQSTIDRILDIFVGLGYTVAEGPQIESDYYNFTALNTPEDHPARDMQDTFYFEDGSLLRTHTSSVQIRYMEKNEPPIRIIAPGRVYRRDTVDATHSAVFHQIEILAVGKGLTFTDLKGTIKEFLRQMFGDDLPTVFRASYFPFTEPSAEVDVQWQGKWLEVLGCGMVDPNVLKAVGYDPEIYTGFAAGLGVERFAMILHKIDDIRRLYNSDLRFLQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z462</accession>
    <name>K9Z462_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219651.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1822"/>
    <dbReference type="EnsemblBacteria" id="AFZ53924">
        <property type="protein sequence ID" value="AFZ53924"/>
        <property type="gene ID" value="Cyan10605_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1822"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1933"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_3"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="34645" checksum="675B7DE69F08DBBB" modified="2013-03-06" version="1">MTSEQYQQKLVVDKGGIRIDVWLGDNIDSISRSRLQKLISEGQVIVNQQVCESKKTILKTGDEVIVRIPPPVSSHLIPEAIPLDILYEDEYLLIINKPANFVVHPAPGHSQGTLVNALLSHCPDLKGIGGVERPGIVHRLDKDTTGAMVVAKTEPVLHHLQGQIKAKTAKREYLGVVYGSPSVSSGIVNLPIGRHPCDRKKMSILSEDKGGKPAVTHWLLKERIGNYSLIHYELETGRTHQIRVHSSHIGHPIIGDPLYSSHGKSVGVNLTGQALHAFRLTLTHPITNNTLEAIAPLPQEFEKLLRILRLKIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E3</accession>
    <name>K9Z4E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219734.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1911"/>
    <dbReference type="EnsemblBacteria" id="AFZ54009">
        <property type="protein sequence ID" value="AFZ54009"/>
        <property type="gene ID" value="Cyan10605_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1911"/>
    <dbReference type="eggNOG" id="ENOG50310U2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346479_0_0_3"/>
    <dbReference type="OMA" id="RRYLWLI"/>
    <dbReference type="OrthoDB" id="1646251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="204" mass="23654" checksum="FB9FEEF549E16605" modified="2013-03-06" version="1">MEIQERASLGWTGVVITTIFMVIVSGLILYPQITIENVLTVLRFSSLTTALPFLLVFVAKPLVTLNIFRDLGQWLQTNRRYLWLILTISHLLHLYQIVLYYQLGNSCPFLVWVLTTPLWLIMVLYSVVELMKPQIFDQLNKNSANRKLNIVYQLGNWYIWLIFTLAFGLGTLAKSLLFYNIPALILFLACAIAYCMTWWGVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E9</accession>
    <name>K9Z4E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="3">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218977.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1126"/>
    <dbReference type="EnsemblBacteria" id="AFZ53248">
        <property type="protein sequence ID" value="AFZ53248"/>
        <property type="gene ID" value="Cyan10605_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1126"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1192"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_4_1_3"/>
    <dbReference type="OMA" id="INTCFIM"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="45744" checksum="A492504F0D7769DF" modified="2013-03-06" version="1">MDLLEYQAKELFSQVGIPVLPSQSIADPSELKNLHIHYPIVLKSQVLVSGRAKFGGVRFVENTIDAIAVAQSLFNLSIEGEYPKVILAESRYDVENEIFLGIMFDYVLKKPVLMGSSQGGINVEILLDNLQTCVIEEEFLPFHARHLVMKMNLKKKAIAPVTAIIEKMYDLFIQNDLDIIEINPLGVKNNGEVMALDGKIRINDDSLNRHPNLLKYLNKDQFLSTVYSCLEINNKSDIVIISDSIDEAIFILNHLEGKNIFTQKLYVLTHKNQQFWTSNINQVFRQIIENTSVKKIIITHSNQDNFVDALIEEIKKSHQEEINYKELISQDREERPTGTRLWNETPKSKQKTNNLYRCIQWSIRTFSPHLLSEQESLNLLPIKIDNNLDKILQIILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I1</accession>
    <name>K9Z4I1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nanE</name>
        <name evidence="6" type="ordered locus">Cyan10605_1167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219017.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1167"/>
    <dbReference type="EnsemblBacteria" id="AFZ53288">
        <property type="protein sequence ID" value="AFZ53288"/>
        <property type="gene ID" value="Cyan10605_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1167"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1233"/>
    <dbReference type="eggNOG" id="COG3010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086300_1_0_3"/>
    <dbReference type="OMA" id="TRPMEIT"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="221" mass="24063" checksum="721A1319771344BD" modified="2013-03-06" version="1">MKELQSSLVISCQAPSNSPLHNPDIIANIALACVNQGAKGLRIDSPNHIKAVRKLLPDIPIIGLWKQMGLDSDVYITPRLEDAIAVAEAGADIIAIDATQRKRPNGETLEEIISHIQQNLHKLVMADIDTKENAIIARDLGVDFIGTTLYGYTQDTRQFTPPNFDLIEELVREIDTPIICEGGIKTPEEAKKALDKGCFCVVVGTAITGIDLLAQNFVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P2</accession>
    <name>K9Z4P2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">Cyan10605_1444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219284.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1444"/>
    <dbReference type="EnsemblBacteria" id="AFZ53555">
        <property type="protein sequence ID" value="AFZ53555"/>
        <property type="gene ID" value="Cyan10605_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1444"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1530"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_3"/>
    <dbReference type="OMA" id="FRVVQMM"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="697" mass="77310" checksum="AEFB70FA538EA45A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q1</accession>
    <name>K9Z4Q1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="9" type="ordered locus">Cyan10605_1583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219419.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1583"/>
    <dbReference type="EnsemblBacteria" id="AFZ53692">
        <property type="protein sequence ID" value="AFZ53692"/>
        <property type="gene ID" value="Cyan10605_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1583"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1681"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_3"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="178"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="429" mass="48809" checksum="21B18D569D60C273" modified="2013-03-06" version="1">MLDIKKIRENPQEVLDKLHKRSPNYELQSILDLDSKQRDIQNIRTELQARSNEIGKLIGQKMREGANPQSEEIITLKQEGNEVKAKLADLEPQERELKANIEALLLELPNLPSDSTPVGKDESQNVEVRRWGDEFIPENKDIIPHGDIGEKWGIINSERAVKVAQSRFIALIGAGAALERALINFMLDQQIEAGYVEIMPPVLVNSETLQGTGQLPKFAEESFKCDKDDLWLTPTAEVPVTNFYRQEILEAEMLPIYHCAFTPCFRREAGSYGRDMRGLIRLHQFHKVELVKIVHPDVSVEEHEKMVKDAERILQALKLPYRVLELCTGDIGFSAAKCYDLEVWMPSANTYREISSCSNCFDFQARRADIRFKEKGKKGTEYVHTLNGSGLAVGRTMAAILENYQLPDGNVRIPEVLQPYLKRDLLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T4</accession>
    <name>K9Z4T4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NAD(P)H-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="11">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NAD(P)H dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NDH-1 subunit I</fullName>
            <shortName evidence="11">NDH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ndhI</name>
        <name evidence="14" type="ordered locus">Cyan10605_1625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">NDH-1 is composed of at least 11 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219459.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1625"/>
    <dbReference type="EnsemblBacteria" id="AFZ53732">
        <property type="protein sequence ID" value="AFZ53732"/>
        <property type="gene ID" value="Cyan10605_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1625"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1725"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122804_0_0_3"/>
    <dbReference type="OMA" id="PVVDWVM"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004497">
        <property type="entry name" value="NADH_plast_OxRdtase_su_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47275">
        <property type="entry name" value="PTHR47275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00403">
        <property type="entry name" value="ndhI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 11" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="2 11" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22115" checksum="9601936918AABA59" modified="2013-03-06" version="1">MFKFLKQVTDYAKGSVEAAKYIGQGFAVTFDHMKRRPVTVQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVDWEFNKAVKKKELKHYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELASYDRHELNYDNVALGRLPTKVTQDPMVTPLKELGYLPKGVLSPHDLPKNSPRDRKHPEDLIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X6</accession>
    <name>K9Z4X6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
            <ecNumber evidence="4">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219197.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1354"/>
    <dbReference type="EnsemblBacteria" id="AFZ53468">
        <property type="protein sequence ID" value="AFZ53468"/>
        <property type="gene ID" value="Cyan10605_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1354"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1428"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_3"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="33662" checksum="668E5F8A7DCA83A3" modified="2013-03-06" version="1">MTSKVQPKLIIHGGAGSSLKGEGGLTAIRESLYGIVTQVYNLLLEGKSATEAVIKGCQLLEDNPRFNAGTGSVLQSDGQIRMSAALMDGEKQRFSGVINVSKVKNPINLANILQNKEDRVLSDYGSAELLRELQLPIYDPLTDLRLQEWIEERKNNFTRKMAGVVAEVSPNARRGTIGVVALDQYGRISAGTSTGGKGLEKVGRVSDSAMPAGNYANSYAGVSCTGIGEDIIDECLAAKIVIRVTDGLSLNEAMEKSMKEAWENKRDLGAIAISRTGNIVLGKTSEILLAAYHDGEKMSDCLEWKGEKLVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z507</accession>
    <name>K9Z507_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="8">S12 MTTase</shortName>
            <shortName evidence="8">S12 methylthiotransferase</shortName>
            <ecNumber evidence="8">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rimO</name>
        <name evidence="12" type="ordered locus">Cyan10605_2170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219981.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2170"/>
    <dbReference type="EnsemblBacteria" id="AFZ54256">
        <property type="protein sequence ID" value="AFZ54256"/>
        <property type="gene ID" value="Cyan10605_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2170"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2306"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_3"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="439" mass="49225" checksum="10F5E1943AD56A21" modified="2013-03-06" version="1">MGNKPTIAVSHLGCEKNRIDSEHMLGLLAKSGYGIDNTEELADYVIVNTCSFIESARRESVRTLVELAENQKKIIIAGCMAQHFQEELLAELPEAVALVGTGDYQNIVDIIERVEKGERVKAVSAEPTFIADENIPRYRTTTEGVAYLRVAEGCDYRCSFCIIPHLRGNQRSRTIESIVAEAQQLADQGVKELILISQITTNYGVDLYGEPKLAELLRALGKVDIPWIRIHYAYPTGLTDKVIDAIASTDNILPYLDLPLQHSHPEILKSMNRPWQGKVNDEIIERIKLALPESVMRTTFIVGFPGETEQHFQHLLQFVKRHQFDHVGVFTFSPEEGTKAYELSNQLPEEVKEERRNQLMEIQQPIAAMKNEAEIGKVVPVLVEQENPMTGELIGRSPRFAPEVDGLVYIKGSANLGEITPVRITSADVYDLYGETEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z510</accession>
    <name>K9Z510_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved TM helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219554.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1724"/>
    <dbReference type="EnsemblBacteria" id="AFZ53827">
        <property type="protein sequence ID" value="AFZ53827"/>
        <property type="gene ID" value="Cyan10605_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1724"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1831"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035789_1_0_3"/>
    <dbReference type="OMA" id="RMGLSIY"/>
    <dbReference type="OrthoDB" id="1861057at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
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            <end position="446"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="534" mass="57505" checksum="B6178C6EF6C9430A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z517</accession>
    <name>K9Z517_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="4" id="KW-1278">Translocase</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="122"/>
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            <end position="741"/>
        </location>
    </feature>
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            <begin position="8"/>
            <end position="74"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="748" mass="81175" checksum="4C0BCB89AA0474CF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z572</accession>
    <name>K9Z572_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219619.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1790"/>
    <dbReference type="EnsemblBacteria" id="AFZ53892">
        <property type="protein sequence ID" value="AFZ53892"/>
        <property type="gene ID" value="Cyan10605_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1790"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1898"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_3"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
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        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
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        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
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        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="285" mass="31968" checksum="1770B6E8860660F0" modified="2013-03-06" version="1">MTIRPRKQFGQHWLKSQKALDTIIFSAELNKSNPQTGTQGDRILEIGPGTGVLTKRLLPLVDKLLAVEIDRDLCKKLVNDYGKTDNFLLLEGDFLELNLPEILQPFPDFLAYNKVVANIPYNITGPIIEKLLGTISKPAEKQLDAIVLLIQKEVGERLTAEPNNKVYGALTLKVQYLADCEIVCTVPARDFYPPPKVDSVVVKITPRNLVNPAKNPAFLDSLIKLGFSSRRKMLKNNLKSLISPEKLNDTLEKLNLNPHARAENLSLEEWINLSNYLTSVGFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B9</accession>
    <name>K9Z5B9_CYAAP</name>
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        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_1644</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="22635" checksum="4FF0AC5785451425" modified="2013-03-06" version="1">MKYNPDIHKRQSIRLKGYDYSQSGFYFITICCYERQCLFGEIINHQIILNNFGELVKEEWLKSAEIRREIELDEFVIMPNHFHGIVIIDQQINKNIVVGANGRSPLQTIQSSQQRISMKPKSLSSLIAGFKSATTKRINIIRDTPKNPVWQRNYYEHIIKNDPSLERIKEYIQNNSLSWENDQLHPNNPSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G0</accession>
    <name>K9Z5G0_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_2295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="Cyan10605_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2295"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12596" checksum="2F7035EA5B6C19B8" modified="2013-03-06" version="1" precursor="true">MKNLSKYSLKNQLITFSICATSFASFGTINIKPAQASFGDFMLGVGAGVGTSVIINNNRRANEDRYRPVPPEQEYFRGRSDGINGLRYDNPRNSPDYDRGFQEGLRIRQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J5</accession>
    <name>K9Z5J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GUN4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219737.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1914"/>
    <dbReference type="EnsemblBacteria" id="AFZ54012">
        <property type="protein sequence ID" value="AFZ54012"/>
        <property type="gene ID" value="Cyan10605_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1914"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2031"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097086_0_0_3"/>
    <dbReference type="OMA" id="VHSEGKF"/>
    <dbReference type="OrthoDB" id="1246541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16383">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008629">
        <property type="entry name" value="GUN4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037215">
        <property type="entry name" value="GUN4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032192">
        <property type="entry name" value="GUN4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34800">
        <property type="entry name" value="PTHR34800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05419">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16416">
        <property type="entry name" value="GUN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140869">
        <property type="entry name" value="SSF140869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GUN4_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GUN4" evidence="1">
        <location>
            <begin position="84"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="26696" checksum="A809A93C482E758E" modified="2013-03-06" version="1">MNELETLKDKFAKTSDKNKIALIDEIVEKGEENYQFLRDFLLSNPEEVSPLKGKIYQVLKHSNHPENETFLNQHFPQGIVQLSSEKNIDYSELQELLIAKKYQEADSLTRVKLCELAGETAIRRKWVYFTEVEKFPETDLLTIDTLWQTYSEGKFGYQIQRQLWLSLGKDYTQLWTKLKWKSGNKWTKYPQEFIWDLSAPIGHLPLSNQLRGVRVMDALLSHPAWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K8</accession>
    <name>K9Z5K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1748"/>
    <dbReference type="EnsemblBacteria" id="AFZ53850">
        <property type="protein sequence ID" value="AFZ53850"/>
        <property type="gene ID" value="Cyan10605_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1748"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_5_0_3"/>
    <dbReference type="OMA" id="IWTPYDL"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="22346" checksum="A6DF902BFCD2E51D" modified="2013-03-06" version="1">MNQKKVLMVHGITDTGKIFQSMGNILEKYGYQPHTIDLIPSIGIADLRDLAQQLKQFINNNFHEQEKINLIGFSMGGLVTRYYLQRLDGIDRVNKYVSISAPNNGTNNAHFLPLKGIQQMRPNSEFLQDLNNDVKDILSKIETLVMWTPFDAMILPPKSSVMGVGKEVNFPVLIHRWMLEDKRVFNAILNFLGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q9</accession>
    <name>K9Z5Q9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-sedoheptulose 7-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219802.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1982"/>
    <dbReference type="EnsemblBacteria" id="AFZ54077">
        <property type="protein sequence ID" value="AFZ54077"/>
        <property type="gene ID" value="Cyan10605_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1982"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2103"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_4_0_3"/>
    <dbReference type="OMA" id="DVHICVP"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00441">
        <property type="entry name" value="gmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="11">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="21613" checksum="445DABEA7A2CA8B0" modified="2013-03-06" version="1">MNFWVEERLQCLQQAFNSEYCQAVEQVSHLLANRFQAGHTLLICGNGGSAADAQHIAAEFVGRFQIDRPGLPAIALGTNPATLTAWGNDHEFETIFARQVQSFGKAGDLLWVLSTSGRSRNILHALKVAKEKGLITIGMAGNNGGMISSLIDYPLFVAEKNTPYVQEIHLITYHRICQQVEAMLFAENIVEKKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S7</accession>
    <name>K9Z5S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219455.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1621"/>
    <dbReference type="EnsemblBacteria" id="AFZ53728">
        <property type="protein sequence ID" value="AFZ53728"/>
        <property type="gene ID" value="Cyan10605_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1621"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1721"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_4_0_3"/>
    <dbReference type="OMA" id="FQTADWA"/>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="9824" checksum="12AF8FA57B69C30F" modified="2013-03-06" version="1">MNNISYLIVTTVANFVQIYLALIIVRILLSWFQTADWAANIISFLAPVTDPYLNIFRSLIPPLGGLDLSPILAIFLLQLVPQLLGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T4</accession>
    <name>K9Z5T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2008"/>
    <dbReference type="EnsemblBacteria" id="AFZ54102">
        <property type="protein sequence ID" value="AFZ54102"/>
        <property type="gene ID" value="Cyan10605_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2008"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2134"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_2_3"/>
    <dbReference type="OMA" id="FVAGPTR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939128" evidence="1">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="324" mass="36681" checksum="02D760EBABAB5353" modified="2013-03-06" version="1">MKYLFFYLTIIFFSLTFTGCNYSPTEDLTVTMSSEKTSINQDEKMRSISHSMGVTQVVENPQRVIILTNEGTDILLALGVKPIGAVKSWQGDPFYDYIENKMTDVMVIGDEFKPNLELIVSLKPDLIIGSKVRQEQLYPQLSAIAPTVFSETIGVTWKDNLKLYAQAVNKEAEAEKLLQEWGQKVATFKEKLGDNPPTVSLVRFIAGNTRLYYEQSFPGQIVAELGLKRPPAQQKKDFADEIAIENIPLLDADYLFYFTDSSQGEKGKASEEKWLNHPLWQNLEVVKNGQIYQVSDAHWTSSSGILAAHKILDDLDNFIFKKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V5</accession>
    <name>K9Z5V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1854"/>
    <dbReference type="EnsemblBacteria" id="AFZ53955">
        <property type="protein sequence ID" value="AFZ53955"/>
        <property type="gene ID" value="Cyan10605_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1854"/>
    <dbReference type="HOGENOM" id="CLU_3364519_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="35" mass="4225" checksum="F33C3A6D06461DA0" modified="2013-03-06" version="1">MQIESNIFGVKKRPYYVMLAFHDPETRKYTDFPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y7</accession>
    <name>K9Z5Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219877.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2063"/>
    <dbReference type="EnsemblBacteria" id="AFZ54152">
        <property type="protein sequence ID" value="AFZ54152"/>
        <property type="gene ID" value="Cyan10605_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2063"/>
    <dbReference type="eggNOG" id="ENOG5031CWS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097729_0_0_3"/>
    <dbReference type="OMA" id="FMRFGCD"/>
    <dbReference type="OrthoDB" id="1810357at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="18420" checksum="DB8F13E0F5086019" modified="2013-03-06" version="1">MNSKNLEIFVKTININDYIILNKEKLLPDWQQVPKTIIFLFFRCQHSLNGNNLKSEEIEKERLLLEFYTLGKKFYYHSQNQKILSEVICPKTGFPIYSNKGKEIFITQQLVKRYLPSFKVKTKECGLFHPLWGQAVYPCIILSGAELTINKSIISAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z628</accession>
    <name>K9Z628_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folate-binding protein YgfZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1934"/>
    <dbReference type="EnsemblBacteria" id="AFZ54030">
        <property type="protein sequence ID" value="AFZ54030"/>
        <property type="gene ID" value="Cyan10605_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1934"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2055"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_3_3"/>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="44078" checksum="1A6F39D92C059553" modified="2013-03-06" version="1">MIYGINYAHERRLYLVSLITSFHWLDHNIMNKLKELQIQSGAVFAENLEVPLTFNNQNFSLSQWEDNIFLCDRSDWGLLKVTGCDRLRFLHNQSTNDIQSLKSGQGCDTVFVNSTGRNIDLVSVYFKEEEVLLLTSPNQNQKLYQWMDRYIFPFDKVELKDISSDYKIFTIFGNNSQELLSNWVDKEILEKPEFYHQNLTIDGIEILLTVGCNLKIKGYNLIVNQDQADIIWQKLIEKKPKLIGSKEWEILRVLRGRPAPEKELTEDFNPLETGLWDSISFSKGCYIGQETIARLNTYKGVKQRLWGIKLNQEINPDIENTIFLGEEKIGRITSFINYENEPFALGYIRTKAGGEGLQVKIGKAEGRVISLPYVIHEYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z688</accession>
    <name>K9Z688_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysS</name>
        <name evidence="12" type="ordered locus">Cyan10605_2161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219972.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2161"/>
    <dbReference type="EnsemblBacteria" id="AFZ54247">
        <property type="protein sequence ID" value="AFZ54247"/>
        <property type="gene ID" value="Cyan10605_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2161"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2296"/>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_3"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="256927at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="406"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="523" mass="60114" checksum="83EDBE1962A62E13" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E0</accession>
    <name>K9Z6E0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220407.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2609"/>
    <dbReference type="EnsemblBacteria" id="AFZ54684">
        <property type="protein sequence ID" value="AFZ54684"/>
        <property type="gene ID" value="Cyan10605_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2609"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2772"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_3"/>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="233"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="53189" checksum="368CF428A5A5567C" modified="2013-03-06" version="1">MLDLEKTLENLDINADWIGLRQVYETTTHRIFRDGKPQSNGRKINHGVMVEVMVNGQIGYCATNHLNQSAIQQAAEIAQQQAEKASKWSIFKFNTDIRPPAKGSYQSPITESANLVHPQELNDLLVQICHRLRVSDKVVKATAMAGISDISSHFVSSNGANIQQQFSLVETDYAAIAQDGNIIQKRSDNGMLARCYQAGKDVFNPEITLNRVQQIGEEAVELVFAQDCPNMTTTLVLAPDQMMLQIHESVGHPLEIDRILGDERNYAGSSFVKLSDFGTLAYGSPLMNITFDPTVKGEFASYGYDDAGLKAEKQYLIKDGILLRGLGSLESQQRSNIQGVANFRSSSWNRPSIDRMANLNLESGNSSFHEIISAIEFGVYMKSNRSWSIDDYRNKFQFGCEYAQLIENGKITKTLRNPNYRGVTQHFWHNLIYVGNESTREFYGTPYCGKGEPNQAIRVGHASPVCAFKDIQVFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I9</accession>
    <name>K9Z6I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sirohydrochlorin ferrochelatase</fullName>
            <ecNumber evidence="4">4.99.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220086.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2278"/>
    <dbReference type="EnsemblBacteria" id="AFZ54362">
        <property type="protein sequence ID" value="AFZ54362"/>
        <property type="gene ID" value="Cyan10605_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2278"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2420"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_0_0_3"/>
    <dbReference type="OMA" id="WCAVRPA"/>
    <dbReference type="OrthoDB" id="1573073at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38919" checksum="3BF2C653A6E745FA" modified="2013-03-06" version="1">MQTAIIEQLPRQEQEITLTPLPYQRPLLMIGHGTKDPHGKQIFLEFVETYQKLDTSRPVIPCFLELTEPNIMTGVDYCVEQGYTDISALPILLFAARHNKFDVTNELDRTRLKYPQLTFHYGRHFGINPSIINLWQERLNQLDSKEYNPHQITREDTVLLFVGRGSSDPDANGDVYKLARILWEGSGYKTVETCFIGITHPRLEEGFRRALLYQPKRIIVLPYFLFMGALMKKIFTITQEHQTTYPEIEIKCLPEMGIQPELLQLVREREIETQLGEVKMNCEMCKFRLNALQNNDHHHHHHDHSHGHHHHHHDNDPLIDPTAYHERIWQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P6</accession>
    <name>K9Z6P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220146.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2338"/>
    <dbReference type="EnsemblBacteria" id="AFZ54422">
        <property type="protein sequence ID" value="AFZ54422"/>
        <property type="gene ID" value="Cyan10605_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2338"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2483"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024631_1_0_3"/>
    <dbReference type="OMA" id="YFFFDGE"/>
    <dbReference type="OrthoDB" id="1137363at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="686" mass="80301" checksum="48EBE5A77EFD92D8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S3</accession>
    <name>K9Z6S3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c-550</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c550</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Low-potential cytochrome c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psbV</name>
        <name evidence="12" type="ordered locus">Cyan10605_2004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="9">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The cyanobacterial oxygen-evolving complex is composed of PsbO, PsbP, PsbQ, PsbV and PsbU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
        <text evidence="9">Associated with photosystem II at the lumenal side of the thylakoid membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cytochrome c family. PsbV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z6S3"/>
    <dbReference type="STRING" id="755178.Cyan10605_2004"/>
    <dbReference type="EnsemblBacteria" id="AFZ54098">
        <property type="protein sequence ID" value="AFZ54098"/>
        <property type="gene ID" value="Cyan10605_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2004"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104149_1_0_3"/>
    <dbReference type="OMA" id="GTCHAGG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018063">
        <property type="term" value="P:cytochrome c-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01378">
        <property type="entry name" value="PSII_Cyt550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029490">
        <property type="entry name" value="Cytochrom_C550"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016003">
        <property type="entry name" value="PSII_cyt_c550"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017851">
        <property type="entry name" value="PSII_PsbV_cyt_c550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14495">
        <property type="entry name" value="Cytochrom_C550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005890">
        <property type="entry name" value="Phot_II_cyt_c550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="17955" checksum="41561B358D46BFF4" modified="2013-03-06" version="1" precursor="true">MKKFVLIFIVGVIFAWQSFVGSANALSLSEEIRTIPLNESGETITLSNQEALKGSRLFVSNCAQCHIQGKTKTNPNVSLSKEALANALPARDNLVGLMDYIEHPTSYDGEEDLTLLHVNTERPDLWPEIRNYSEDDIKAVAGHILIQAFSDPKWGNLSLIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y9</accession>
    <name>K9Z6Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219878.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2064"/>
    <dbReference type="EnsemblBacteria" id="AFZ54153">
        <property type="protein sequence ID" value="AFZ54153"/>
        <property type="gene ID" value="Cyan10605_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2064"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2193"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064068_0_0_3"/>
    <dbReference type="OMA" id="AARRDYM"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="387" mass="40169" checksum="2AD7CD1A4D58DD4B" modified="2013-03-06" version="1">MSIIIGRGKSARRAYGIDEIALAPGNRTLDPSLADTRVNLGGIEREVPIIASAMDGVVDVRMAVLLSELGALGVLNLEGIQTRYEDPNPILDRIASVGKSEFVGLMQELYSEPIKPELIKQRVIEIKEQKGIAAVSFTPAGASQYGKVVAEAGADLVFIQATVVSTAHLSPESITPLDLAGFCAEMPMPVILGNCVTYDVALNLMKAGAAGVLVGIGPGAACTSRGVLGVGVPQATAVADCAAARDDFEKETGKYVPIIADGGIITGGDICKCIACGADAVMIGSPIARSEEAPGRGFHWGMATPSPVLPRGTRINVGTTGTIKEILRGPAKLDDGTHNLLGALQTSMGTLGAKNIKEMQEVEVVIAPSLLTEGKVYQKAQQLGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z723</accession>
    <name>K9Z723_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photosystem II lipoprotein Psb27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Photosystem II 11 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psb27</name>
        <name evidence="3" type="ordered locus">Cyan10605_2878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the repair and/or biogenesis of the calcium-manganese-oxide cluster on the lumenal face of the thylakoid membrane. Its presence in a photosystem II (PSII) preparation prevents binding of some small extrinsic subunits and thus assembly of calcium-manganese-oxide cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Forms a complex with a monomeric, partially assembled PSII. This is probably the complex in which D1 is assembled and/or replaced.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cellular thylakoid membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
        <text evidence="1">Associated with PSII on the lumenal side of the thylakoid membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Psb27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220666.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2878"/>
    <dbReference type="EnsemblBacteria" id="AFZ54944">
        <property type="protein sequence ID" value="AFZ54944"/>
        <property type="gene ID" value="Cyan10605_2878"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2878"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3059"/>
    <dbReference type="eggNOG" id="ENOG5031CPI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112237_2_0_3"/>
    <dbReference type="OMA" id="HYSSYPN"/>
    <dbReference type="OrthoDB" id="1677766at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031977">
        <property type="term" value="C:thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010206">
        <property type="term" value="P:photosystem II repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01481">
        <property type="entry name" value="PSII_Psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025585">
        <property type="entry name" value="PSII_Pbs27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038450">
        <property type="entry name" value="PSII_Pbs27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017488">
        <property type="entry name" value="PSII_Psb27_cyano_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041">
        <property type="entry name" value="PTHR34041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13326">
        <property type="entry name" value="PSII_Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03044">
        <property type="entry name" value="PS_II_psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0793">Thylakoid</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938620" description="Photosystem II lipoprotein Psb27" evidence="2">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15445" checksum="E1BC66BE6C5EE07F" modified="2013-03-06" version="1" precursor="true">MIKSYLRKIISLVLIVTIALFSFSQGAIALTGKYTDDTLTVIEDLTQVIETPADASIEVKRENQTLARKQINDYVSRYRKNNKYSGLKSFTTMQTALNSLAGYYTSYGNRPMPEKLKKRLLQEFKQVEFAIKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z727</accession>
    <name>K9Z727_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220270.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2466"/>
    <dbReference type="EnsemblBacteria" id="AFZ54547">
        <property type="protein sequence ID" value="AFZ54547"/>
        <property type="gene ID" value="Cyan10605_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2466"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2611"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_4_3"/>
    <dbReference type="OMA" id="FLTIWFA"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="465" mass="49731" checksum="1A4C6CD430EEDD04" modified="2013-03-06" version="1">MTNQKNISLISTVELSKLIHSKEISPLEVLEFYAPQIEEKNPKLGAFTYLDLDLAHKEAKEKTEILAQVDDTSCLPFFFGIPTAIKDLYPVKGMPTSYGNGFVKDQIADYDCGITGKIKEAGFIIVGKTATSELGSLPYTESIGLLPCRNPHNLDYTAGGSSGGAASAVAGGLLPIAPGSDGGGSVRGPAFCCGLVGLKPSRGRVSNAPVGDYQGGIATHGCLSRTVADSAALLDAIAGYITGDPYWLPNPETSFLSALTQETGKLKIAFATSVLPAGEVDPILKTQVDAIALHLQEMGHELVEACPDFTTLVEPFKIIWQSGITAAGFPEQILNPMNQWLKQNSPDLGTYLRAVHQMQVISRQIVGFFDHFDLLLLPTYMSPPIKIGAWADLPPEKTLEKIIHWINPCPPFNATGQPAIALPTGFTEDNLPIGVQLIGKPADEKTLLQIAHQLETGNKLSSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z770</accession>
    <name>K9Z770_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219938.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2125"/>
    <dbReference type="REBASE" id="58401">
        <property type="entry name" value="M.Cap10605ORF2125P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54213">
        <property type="protein sequence ID" value="AFZ54213"/>
        <property type="gene ID" value="Cyan10605_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2125"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2260"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459013_0_0_3"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20538" checksum="A15F8E9040BE7847" modified="2013-03-06" version="1">MSTINLSGSYQILHSKNKSKFEVIELFAGCGGMALGFENAGLNTKLLVDINKNSCETLQKNRPNWNVINQDITQLDSYYQGGGRTGFAKRLAYDEPCLTLTCSPSQTQTERCHPIETRPLTIREYARVQTFPDDWEFAGSLTSQYQQIGNAVPVNLAYHLGCSLIAMLEGKTGLCSEKVTQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z773</accession>
    <name>K9Z773_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220315.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2511"/>
    <dbReference type="EnsemblBacteria" id="AFZ54592">
        <property type="protein sequence ID" value="AFZ54592"/>
        <property type="gene ID" value="Cyan10605_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2511"/>
    <dbReference type="HOGENOM" id="CLU_135021_2_0_3"/>
    <dbReference type="OMA" id="MNAFQPS"/>
    <dbReference type="OrthoDB" id="1774049at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="15691" checksum="9CEE8AEAD1F0886B" modified="2013-03-06" version="1">MNSNLSLKTRQRRRDYQESISQNRALKQQQRRQKRLNTEKAIETGLKMTVNISITIIAFFSVKQLLPYHLAQQAKLAEIDGEIAKIKPRVEKLEEDFGNTFDPKLTRKVIEKNTYKADPNLSPIFFIDKKQQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A1</accession>
    <name>K9Z7A1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="4" type="synonym">rps21</name>
        <name evidence="6" type="ordered locus">Cyan10605_3017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220795.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3017"/>
    <dbReference type="EnsemblBacteria" id="AFZ55076">
        <property type="protein sequence ID" value="AFZ55076"/>
        <property type="gene ID" value="Cyan10605_3017"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3017"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3215"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_3_1_3"/>
    <dbReference type="OMA" id="HHETPFE"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="6968" checksum="FD3EE51AE4F29A3F" modified="2013-03-06" version="1">MTQVVVGQNENIESALRRFKRQVSKAGIFADIKRLRHYETPIEKKKRKAVARRKKRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F3</accession>
    <name>K9Z7F3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ordered locus">Cyan10605_2222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220033.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2222"/>
    <dbReference type="EnsemblBacteria" id="AFZ54308">
        <property type="protein sequence ID" value="AFZ54308"/>
        <property type="gene ID" value="Cyan10605_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2222"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2361"/>
    <dbReference type="eggNOG" id="COG1828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164833_0_0_3"/>
    <dbReference type="OMA" id="IENYRFE"/>
    <dbReference type="OrthoDB" id="2012814at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="9699" checksum="3D52867846F5606E" modified="2013-03-06" version="1">MSQKFNSRVYVTLRPSVLDTAGTAVESGLHQLGYQGVENVRIGKYIELSITAANKEEADQQLHAMCDQLLANPVIENYCFELIPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K0</accession>
    <name>K9Z7K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Molybdate ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220410.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2612"/>
    <dbReference type="EnsemblBacteria" id="AFZ54687">
        <property type="protein sequence ID" value="AFZ54687"/>
        <property type="gene ID" value="Cyan10605_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2612"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2775"/>
    <dbReference type="eggNOG" id="COG1118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_17_2_3"/>
    <dbReference type="OMA" id="NTFPCWL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="255"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="614" mass="69088" checksum="B3CA91CBBF06C703" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N0</accession>
    <name>K9Z7N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220450.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2653"/>
    <dbReference type="EnsemblBacteria" id="AFZ54727">
        <property type="protein sequence ID" value="AFZ54727"/>
        <property type="gene ID" value="Cyan10605_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2653"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2818"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291303_0_0_3"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117804" checksum="555EAF552AF1DB4C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P1</accession>
    <name>K9Z7P1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">Cyan10605_2524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220328.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2524"/>
    <dbReference type="EnsemblBacteria" id="AFZ54605">
        <property type="protein sequence ID" value="AFZ54605"/>
        <property type="gene ID" value="Cyan10605_2524"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2524"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2676"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_3"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="363" mass="39069" checksum="8483F52C81C2E8D1" modified="2013-03-06" version="1">MSSIFGKLFTISTFGESHGGGVGVIVDGCPPRVEISAEEIQSELNRRKPGQSKITTPRQESDLCEIVSGVFQGKTLGTPIAILVRNKDARSQDYDEMAVKYRPSHADATYDAKYGIRNWQGGGRSSARETIGRVAGGAIAKKILHQIAGVEIIAYVKTIKDISASVDQETVTLEQVESNIVRCPDSVAAEKMIELIDQIRREKDSLGGVVECVVRNVPKGLGEPVFDKLEADLAKAIMSLPATKGFEIGSGFEGTLLTGSQHNDEFYLDEAGNTRTMTNRSGGIQGGISNGENIVIRAAFKPTATIGKEQKTVTKEGEETVLAAKGRHDPCVLPRAVPMVEAMVALVLCDHLLRHHAQCGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U5</accession>
    <name>K9Z7U5_CYAAP</name>
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        <submittedName>
            <fullName evidence="6">Sodium/proton antiporter, CPA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2577"/>
    <dbReference type="EnsemblBacteria" id="AFZ54655">
        <property type="protein sequence ID" value="AFZ54655"/>
        <property type="gene ID" value="Cyan10605_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2577"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2738"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_10_1_3"/>
    <dbReference type="OMA" id="KWEGILI"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger"/>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
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            <end position="256"/>
        </location>
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            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
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            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
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            <end position="393"/>
        </location>
    </feature>
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            <begin position="402"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="633" mass="68133" checksum="F0D28AD4CF745559" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z6</accession>
    <name>K9Z7Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
            <ecNumber evidence="2">3.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EC" id="3.5.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220241.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54518">
        <property type="protein sequence ID" value="AFZ54518"/>
        <property type="gene ID" value="Cyan10605_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2437"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2581"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_3"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050118">
        <property type="term" value="F:N-acetyldiaminopimelate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="395" mass="43256" checksum="59B85C477A43F8B6" modified="2013-03-06" version="1">MVNESQIRDAIALLQPELVQWRRQIHQYPELGFKEVLTANFVSEKLSQWGIAHEKGVAKTGIVAVINSNYEGKVLAIRADMDALPIQEENSVSYCSKHDGIMHACGHDGHTAIALGIAHYLAHNRDKWRGTVKIIFQPAEEGPGGAKPMIEQGVLSNPDVDAIIGLHLWNNLPVGTIGVREGALMAAVECFKCTIFGKGGHGAMPDQTIDSVVVGSQIVNALQTIVARNIAPVDSAVVTVGEFHAGTALNVIADTAKMSGTVRYFNPKLESFIGQRIKDIIGGICQSHGAEYELDYWQLYPPVINNPQITQLVKSVAMEVVETPMGVVPECQTMGGEDMSFFLQEVPGCYFFLGSANADKKLNYPHHHPRFDFDETVLSMGVEIFARFVEKFNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z809</accession>
    <name>K9Z809_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220418.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2620"/>
    <dbReference type="EnsemblBacteria" id="AFZ54695">
        <property type="protein sequence ID" value="AFZ54695"/>
        <property type="gene ID" value="Cyan10605_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2620"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2783"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570762_0_0_3"/>
    <dbReference type="OrthoDB" id="1300203at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="478" mass="54460" checksum="FEA2EA255CCC9B98" modified="2013-03-06" version="1">MTDNKKATKHSTTETNINVEGLSEIILECYKKNNKLKIRVISEGYDSELNVRFPRDLREEGALYSVETIEKTKGNYYLVKGNITKIDQDLDSVIAKNSDLNNEQSQTILTEEKTLKETTTPQDLTELANERAEASGETTTSERLKELANKSIELACLVAQNPHCPSDLLAELAHNEDRLIRQAVTNNPNTPKNTLLKLGTEFPEELLDNPIFDLLLLENPNLLAEMPTSTLKSMVKIETVPNSFLNWAVNYGDDEVLIALLSNPQLSQEDLVQLTKHKNPQIVEEAKLHINWNEEIENPEEFIRKALRYNNLSSYMLREELEFFVNYFFKEMISSQWGYDLLFSNKNLRISLASNPNTPVRVLEKLATDDDKDVRRSVAENPNTPVTLSKKLGIDYIFRISEKSRRPDLGCLAVFLSPYAETSHLAKNFRSTSWLERWAIAQNPNTPENTLSYLVQDGNRLVRSAAELNIKQRQNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z833</accession>
    <name>K9Z833_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2467"/>
    <dbReference type="EnsemblBacteria" id="AFZ54548">
        <property type="protein sequence ID" value="AFZ54548"/>
        <property type="gene ID" value="Cyan10605_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2467"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2613"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025251_0_0_3"/>
    <dbReference type="OMA" id="YNGHDNI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="322"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="592" mass="66414" checksum="C69D1904F82C4F76" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z854</accession>
    <name>K9Z854_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ordered locus">Cyan10605_2676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220473.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2676"/>
    <dbReference type="EnsemblBacteria" id="AFZ54750">
        <property type="protein sequence ID" value="AFZ54750"/>
        <property type="gene ID" value="Cyan10605_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2676"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2841"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_3"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28422" checksum="61E8864D7C4363FE" modified="2013-03-06" version="1">MSTSAQKLYEGKAKIVYATEKEQEYLTYFKDDATAFNAQKKGTIVGKGEINCTVSSALLKWLESKGIPTHFIDQPSSREMLVKAVKIIPLEVVVRNIAAGSLCKQTGLNQGEKLPFPLVEFYLKNDELGDPLLTRDRLSILNIIPSEQIEQLKQYALQINQHLQEFFQSCQITLVDFKLEFGFDSENNIILADEISPDTCRLWDELEQDKQKRVLDKDRFRQDLGKIESAYQEVQQRVLTQIEKLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E2</accession>
    <name>K9Z8E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221179.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3421"/>
    <dbReference type="EnsemblBacteria" id="AFZ55461">
        <property type="protein sequence ID" value="AFZ55461"/>
        <property type="gene ID" value="Cyan10605_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3421"/>
    <dbReference type="eggNOG" id="ENOG50332YF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177503_2_1_3"/>
    <dbReference type="OMA" id="NAIQICN"/>
    <dbReference type="OrthoDB" id="2056467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8144" checksum="5393E3E13EB14B9C" modified="2013-03-06" version="1" precursor="true">METITIKVDSEIAKAYQQADATKQENAIQICNLVLKQLLKPDSFEEIVTQIREEAKVNGLTPEILTQLLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I8</accession>
    <name>K9Z8I8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">Cyan10605_3434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221192.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3434"/>
    <dbReference type="EnsemblBacteria" id="AFZ55474">
        <property type="protein sequence ID" value="AFZ55474"/>
        <property type="gene ID" value="Cyan10605_3434"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3434"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3659"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_3"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="6">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="240" mass="25991" checksum="436B23424245D1B6" modified="2013-03-06" version="1">MTYQRILLKLSGEALMGNLGYGIDPKVVAEIAEDIAQVVAQNVQVAIVVGGGNIFRGVQASAKGMDRATADYVGMIATVMNAMTLQDALERMNVPTRVQTAIAMQEVAEPYIRRRAIRHLELGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKATKVDGVYDSDPVTNPNARRYESLNYNHVLTNDLRVMDGTAIALCKENNIPIVVFNLFERGNIIRAVKGEKVGTIVGGFCDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J6</accession>
    <name>K9Z8J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221202.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55484">
        <property type="protein sequence ID" value="AFZ55484"/>
        <property type="gene ID" value="Cyan10605_3444"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3444"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149845_0_0_3"/>
    <dbReference type="OrthoDB" id="1562645at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="13100" checksum="C51F93F89ED9B212" modified="2013-03-06" version="1">MYSSAFIFEPGEYDEQFYFLDNQIHEAAASVNGFLGRESWESIDGKRKNAIYYWESMDALKEFSRHPKHIEAKRQYTKWYKGFHVVISEVKHSYGDGKLEHITPNDRAKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L1</accession>
    <name>K9Z8L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abi family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221254.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3503"/>
    <dbReference type="EnsemblBacteria" id="AFZ55536">
        <property type="protein sequence ID" value="AFZ55536"/>
        <property type="gene ID" value="Cyan10605_3503"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3503"/>
    <dbReference type="eggNOG" id="COG4823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044962_2_1_3"/>
    <dbReference type="OMA" id="RNVCAHN"/>
    <dbReference type="OrthoDB" id="929031at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011664">
        <property type="entry name" value="Abi_system_AbiD/AbiF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07751">
        <property type="entry name" value="Abi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="34572" checksum="317B250775F94C3F" modified="2013-03-06" version="1">MLFNKSPKTIDEQIELLISRGMIITDHPKVHDVLTHVNYYRLGAYWLPFEQDHENHIFRSGTYFDDVLNLYIFDRKLRLLVLDAIERIEVSCRTQWAYFMAHNHGSHSYLDSTLARKESYWVSNLQSLENEVKRSKEVFIEHYKNKYTQPDLPPIWAVSEVMSLGLFSRWFTNLKPMATRKKIANQYNLDHEILASFLRHLTEVRNICAHHSRLWNRKFTVTLTIPKNPTYLAEKMNQNEKRRLYNTLVMLNYLLNFVSPNNSWYKQLIELIQEHQINHNLMGFTEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L3</accession>
    <name>K9Z8L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-dependent nickel-iron dehydrogenase diaphorase component subunit HoxE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3468"/>
    <dbReference type="EnsemblBacteria" id="AFZ55504">
        <property type="protein sequence ID" value="AFZ55504"/>
        <property type="gene ID" value="Cyan10605_3468"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3468"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3693"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_3"/>
    <dbReference type="OMA" id="HIIRYCD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="20068" checksum="01FCC14DD18567F6" modified="2013-03-06" version="1">MFKVGFSWGLILLRGIMTTTIESPAENTQVKDKRFKILDVVIKKNHSRQDALIQVLHKAQSTFGYLEDDVLIYVARQLKLPLSEVFGVATFYHLFSLKPSGAHNCVVCLGTACYVKGSSELLEKLAEATGLQQGETSADGKVSLLTARCIGACGLAPSVVYDGKVCGKQTADEVVKKVTSWLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L6</accession>
    <name>K9Z8L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221258.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55541">
        <property type="protein sequence ID" value="AFZ55541"/>
        <property type="gene ID" value="Cyan10605_3508"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3508"/>
    <dbReference type="HOGENOM" id="CLU_1537540_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="19544" checksum="15B9CA8788F28AF2" modified="2013-03-06" version="1">MTNQNENGCAGCLSLIIALFVVGLLVSYWQLVLAFVFVIFVFWVLFKIITSICHSVFGGRNTSSYRPMTTKFNSNDANTPFYTIDMKADAIDHPSASKTIKPKQKSSNLVKKDSPKTEIEMTVNTSNKSKLVKKNVQTNLTGDIDINIKDKKIKSVKYTKTTIEEVVYEIDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L7</accession>
    <name>K9Z8L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220411.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2613"/>
    <dbReference type="EnsemblBacteria" id="AFZ54688">
        <property type="protein sequence ID" value="AFZ54688"/>
        <property type="gene ID" value="Cyan10605_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2613"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2776"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_3"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13537">
        <property type="entry name" value="PBP2_YvgL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041879">
        <property type="entry name" value="YvgL-like_PBP2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30316" checksum="0C95771DE83E6CCB" modified="2013-03-06" version="1">MGWRENWLIFFSVIICFSLLKIDFYGLDDKQSNKINLGNSATQITVSCAASLKNIMEEIKPLYEQKYSQTQLIYNFGSSGSLQRQIEQGAPVDVFISAADKQINALEKKGLLLEGTRYDLVSNKIVLIVPKNHNKNKVNITNFTDLTNTNITKIALGEPQSVPAGKYAQEVLHYYKITEQINAKAVYGKDVRQVLNYVATGNVDAGIVYLTDAKIEDEVKVVTTAPSGSHSPVVYPIAVVKDSKNPQESKQLINFLSTSEIQTMFTKYGFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N7</accession>
    <name>K9Z8N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55529">
        <property type="protein sequence ID" value="AFZ55529"/>
        <property type="gene ID" value="Cyan10605_3494"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3494"/>
    <dbReference type="HOGENOM" id="CLU_111019_0_0_3"/>
    <dbReference type="OMA" id="HTISGCA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="22849" checksum="5FF81702EBA4278C" modified="2013-03-06" version="1">MMVNAVLLNMNKKYLIIIITFFISFIPNFIVLANNQNQEIIQEVYKNRKKINLCPDALVWDYAQTVSEVIKFNQQEYIVIFYCFLAAYQTNFSFVKYVKTNSGNQIELLKLDGFQENELGKLERTNVDNFAGFIYRDEKNPSILKIHTISGCAKNIGALATYKINGSNFTLLEYRAKTDCTDVFVEPENYPLIYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z965</accession>
    <name>K9Z965_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220985.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3220"/>
    <dbReference type="EnsemblBacteria" id="AFZ55267">
        <property type="protein sequence ID" value="AFZ55267"/>
        <property type="gene ID" value="Cyan10605_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3220"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3433"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_1_3"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="385" mass="42489" checksum="53AE3CCF66A2C8EF" modified="2013-03-06" version="1">MSNLPESEAQKALQKESELSFTGWQQEVQQGLDYGLEAAESIKDRTISTFSRGELPHYAGINTFLKAPYLEDVKQVGNYDVAIVGVPHDSGTTYRPGTRFGPQGIRKISALYTPYNFELGVDLREQIKLCDVGDIFTIPANNEKSFDQISKGVAHIFKSGAFPIILGGDHSIGFPTLRGVCRHLGDKKVGIIHFDRHVDTQETDLDERMHTCPWFHATNMKNAPAKNLVQLGIGGWQVPRQGVKVCRERATNILTVTDITEMGLDAAADFAIEKATDGTDCVWISFDIDCIDAGFVPGTGWPEPGGLLPREALYLLKKIVQNTTVCGIEVVEVSPPYDVSDMTALMATRVICDTMAHLVVSGQLPRKQKPDYIHEEAQVVDQPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E2</accession>
    <name>K9Z9E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHP02436-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220909.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3139"/>
    <dbReference type="EnsemblBacteria" id="AFZ55190">
        <property type="protein sequence ID" value="AFZ55190"/>
        <property type="gene ID" value="Cyan10605_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3139"/>
    <dbReference type="eggNOG" id="ENOG5032RWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_2_0_3"/>
    <dbReference type="OMA" id="ADETKYW"/>
    <dbReference type="OrthoDB" id="1986697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035652">
        <property type="entry name" value="CHP02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13472" checksum="3E39018C8A40EDFD" modified="2013-03-06" version="1">MEYDISERTLSFSIRIVNLCKFLRENGGTGYDLSKQLIRCGTSIGANIEEAQNAESTADFIHKMSISLKEARETKYWLRILIATEKKLGSRLQPLLHESHELVAIIYTIVKNAKTNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K7</accession>
    <name>K9Z9K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamentous hemagglutinin family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220978.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3213"/>
    <dbReference type="EnsemblBacteria" id="AFZ55260">
        <property type="protein sequence ID" value="AFZ55260"/>
        <property type="gene ID" value="Cyan10605_3213"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3213"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3425"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224734_0_0_3"/>
    <dbReference type="OMA" id="WLHGGQG"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043709">
        <property type="entry name" value="DUF5649"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18886">
        <property type="entry name" value="DUF5649"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01901">
        <property type="entry name" value="adhes_NPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haemagg_act" evidence="2">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2584"/>
            <end position="2609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="3090" mass="321156" checksum="1CACD49C5740B94E" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P9</accession>
    <name>K9Z9P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">obg</name>
        <name evidence="8" type="ordered locus">Cyan10605_3046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3046"/>
    <dbReference type="EnsemblBacteria" id="AFZ55103">
        <property type="protein sequence ID" value="AFZ55103"/>
        <property type="gene ID" value="Cyan10605_3046"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3046"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3242"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_0_3"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="171"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="37263" checksum="B2D29442BE67390D" modified="2013-03-06" version="1">MFGVKNKAIQLMQFIDQVKIEVQAGKGGDGIVAFRREKYVPAGGPAGGNGGRGGSIILKAVNRLQTLLDFKYARHFQAEDGKRGGPNNCTGASGKDLILEVPCGTMVYDLETDELIVDLVDNEQTFVIAKGGKGGLGNKHFLSNSNRAPEYALPGLEGDYRQLRLELKLLAEVGIIGLPNAGKSTLISALSSARPKIADYPFTTLVPNLGVVRKPTGDGTVFADIPGLIEGASLGIGLGHDFLRHIERTRVLLHLVDINSDDPLHDYNIIQNELQAYDKGLGDRPQIIGLNKIDTLDDSRQNEIIEEFKTVTKDPIFLISAVTQKGCDRLLQAIWDQLDSLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Q9</accession>
    <name>K9Z9Q9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221175.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3415"/>
    <dbReference type="EnsemblBacteria" id="AFZ55457">
        <property type="protein sequence ID" value="AFZ55457"/>
        <property type="gene ID" value="Cyan10605_3415"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3415"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3639"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_2_0_3"/>
    <dbReference type="OMA" id="CDKIVFP"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21095" checksum="47CCF2C468E69234" modified="2013-03-06" version="1">MTISLKKGERISLAKVAPSLVAGFIGLGWDVNVTDTGGDFDLDVSVFLLGDNDKLVSDKHFIFYNNLVSPDSDQSVKLLGDNRTGEGEGDDEGLIVDLRKVPVDVAKIVVTVTIYEADKRKQNFGQVSNAYIRLVDVQTKEEVLRYDLTEDFSVETAVIMAELYRKDGEWRLNAVGSGFQGGLQALLDRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y9</accession>
    <name>K9Z9Y9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnB</name>
        <name evidence="3" type="ordered locus">Cyan10605_3363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221123.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3363"/>
    <dbReference type="EnsemblBacteria" id="AFZ55405">
        <property type="protein sequence ID" value="AFZ55405"/>
        <property type="gene ID" value="Cyan10605_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3363"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3581"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_1_3"/>
    <dbReference type="OMA" id="IRGHGLY"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01677">
        <property type="entry name" value="Salvage_MtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="13"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="23469" checksum="94B28E2E25D489F4" modified="2013-03-06" version="1">MVYSQFDFDQACQSIISTANYLYSQGWTPATSSNFSQKLDNNYCAITVSGKDKGRLIADDIMIVDFEGKPQTNQKPSAETLLHTSLYGWNDTIGAVLHTHSLNTTLISLLTNNNILQLEGYELLKAFSGISTHENAIAFPIFENTQDIANLAQEVINYLNTDVPCWGYLIKGHGVYTWGEDMASALRHLEAIEYLMKCELEIMRIKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAH5</accession>
    <name>K9ZAH5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin amidase</fullName>
            <ecNumber evidence="4">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221111.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3351"/>
    <dbReference type="EnsemblBacteria" id="AFZ55393">
        <property type="protein sequence ID" value="AFZ55393"/>
        <property type="gene ID" value="Cyan10605_3351"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3351"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3569"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_0_1_3"/>
    <dbReference type="OMA" id="MCTRLVY"/>
    <dbReference type="OrthoDB" id="636485at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="31"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="40139" checksum="768CD6E9DA60D5F6" modified="2013-03-06" version="1" precursor="true">MTFLHILKSISLVIPTTLTLSALFGLSVLACTRVVYSGSDNTVITGRSMDWKEDIRSNLWVFPRGRDRNGLAGENSIEWKSKYGSVVVTGYDIGTADGMNEKGLVANLLYLAESDYGDTQGKPTLSMSLWAQYVLDNYATVAQAVEELKNEPFRVITSTLPNGSQAQLHLAISDSSGDSAIFEYIDGKLVIHHSKEYKVVTNSPIFEKQLALNQYWQSIGGLNFLPGTNRAADRFARAYFLLNSIPKQTVSNYISAVPEQKYQNQALASVLSVVRSVSVPLGITTPDQPNIASTVWRVVADQKNMTYYFDSATSPNVFWIDFSQLDFSPTASVKKLSLTDGTFYAGDATDNLVSETPFQFLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAM2</accession>
    <name>K9ZAM2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221161.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3401"/>
    <dbReference type="EnsemblBacteria" id="AFZ55443">
        <property type="protein sequence ID" value="AFZ55443"/>
        <property type="gene ID" value="Cyan10605_3401"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3401"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3621"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_3"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="441" mass="46575" checksum="580BB95BBCCFA7A7" modified="2013-03-06" version="1">MIYDIFMPALSSTMTEGKIVSWEKQPGDKVEKGETVVVVESDKADMDVESFYSGYLATILVPAGSQAPVGDAIAYIAETEAEIEEAKKKASQAQGGNNVTSTPATTPEFKKEVETSPQPVATTANTEISPSNTSENNGRIIASPRAKKLAKEFKVDLATIKGSGVNGRITAEDVEKAVGKAPSVTTSTPSLPTITSSIPPQITPTPALGNAAPINNLAGETVPFNTLQQAVVRNMVASLHVPTFQVSYDITTDALDGLYRKIKTKGVTMTALLAKAVAVTLQKHPIMSATYTEGGIKYNDSINIAVAVAMPDGGLITPVIKNAAQIDIYSLARSWKDLVDRARAKQLQPDEYSTGTFTLSNLGMFGVSSFTAILPPGQGSILAIGGTRPAVVASKDGLFGVKNQMTVTITCDHRIIYGADAASFLKDLANLIENDPHSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZC3</accession>
    <name>K9YZC3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217986.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0095"/>
    <dbReference type="EnsemblBacteria" id="AFZ52254">
        <property type="protein sequence ID" value="AFZ52254"/>
        <property type="gene ID" value="Cyan10605_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0095"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.97"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_3"/>
    <dbReference type="OMA" id="IAFFIAW"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="31068" checksum="8A82AD52E7D50069" modified="2013-03-06" version="1" precursor="true">MGNKKTLIQIITIYILLIIIALAMLFPLFWLLSTSFKSAGEDIFAFPPQFIPQQFTLENFVLVWQNYPFGKYLLNSSISAVLTVSLNLLFCALAAYPLARLEFKGRDFIFVLIVATIMIPFQIVMIPLYIFAVNLGLKNNYLGLILPQITSAFGIFLLRQAFQGVPKELEEAGRMDGCSELGIWWHIMLPAIRPAIITLAIFVFIGSWSDFLWPLIILDRPDYYTLPLGVASLASSLDLNWRFIAAGSIISLVPVLVLFITLQHYIIPSDANTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZP9</accession>
    <name>K9YZP9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218158.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0276"/>
    <dbReference type="EnsemblBacteria" id="AFZ52426">
        <property type="protein sequence ID" value="AFZ52426"/>
        <property type="gene ID" value="Cyan10605_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0276"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.286"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093809_0_0_3"/>
    <dbReference type="OMA" id="DSRDCKQ"/>
    <dbReference type="OrthoDB" id="1767588at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="22153" checksum="FC763A3B66EA2ADE" modified="2013-03-06" version="1" precursor="true">MSIAPFISGLIKVCLILFCSLSIWLTNTSSSYADINNDRYDGNIFVVYAGNGSLVPPKLTLKQSFDRKIPVILVYYLDDNSDSKQFAFIVSRLQEFYGKVASIIPVSVDSIPVKEKYQPDEVGYYYRGAIPQTVVLDENRQKVFDEAGVIQFEAVDDVLRKVFNLLPRSQSVELKRKTFNEFNSELVPEEKGNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZR1</accession>
    <name>K9YZR1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218136.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52404">
        <property type="protein sequence ID" value="AFZ52404"/>
        <property type="gene ID" value="Cyan10605_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0254"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053514_1_1_3"/>
    <dbReference type="OMA" id="LWFTRWQ"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="266" mass="30092" checksum="364E4E6D904A5E2A" modified="2013-03-06" version="1">MDFLFLSKLLPLFLYPLGFACFSLLIALVLWWKFPRFLPIPIILALLVLFLSSNFFVSNLLVKSLEWQYLASPSSIDNAQAIVVLGGGIKPLVYPRPMIDLAEQGDRVIYASQLYKMKKSPLILVSGGRIPWKALESQSSEASDMTKLLVLLGVPESAIIKEGKSLNTYENAVNTRLILEEKGIKQIILVTSALHMPRSVKIFQKQGFDVIPAPTDFFVTEQDFIKDDSWQNIIINLFPNSTYLYNTNLALKEYLGIIIYKLKGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZU6</accession>
    <name>K9YZU6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Assimilatory nitrite reductase (Ferredoxin)</fullName>
            <ecNumber evidence="5">1.7.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
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            <strain evidence="6">PCC 10605</strain>
        </source>
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    </dbReference>
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        <property type="gene ID" value="Cyan10605_0291"/>
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    <dbReference type="KEGG" id="can:Cyan10605_0291"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.302"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="519" mass="57921" checksum="BF072E16F3CEF25C" modified="2013-03-06" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="AFZ52474">
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        <property type="gene ID" value="Cyan10605_0327"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.341"/>
    <dbReference type="eggNOG" id="COG1100">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="536" mass="58943" checksum="34D56471F1DBD0A3" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z014</accession>
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    </protein>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">PCC 10605</strain>
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        <property type="project" value="InterPro"/>
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        </location>
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        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
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            <end position="455"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="522" mass="56718" checksum="F9CB13FD763B6410" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M3</accession>
    <name>K9Z0M3_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0597</name>
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    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_015218467.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0597"/>
    <dbReference type="EnsemblBacteria" id="AFZ52736">
        <property type="protein sequence ID" value="AFZ52736"/>
        <property type="gene ID" value="Cyan10605_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0597"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_8_0_3"/>
    <dbReference type="OMA" id="HSYYAPY"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="391" mass="45870" checksum="C6A10D0C4DD8CEAE" modified="2013-03-06" version="1">MIPDKSFRPHGIKVTIQNRSGLIRLLYTYKGKREIISYPLNYFDPQNQQIAIAKATEIHNDIYLYQKYDETKEKYQLKPKLIKHDFGQKEITIREIWEFYKELKKEEIATNTQKNNWSKIDKTLDDNLTVDQIPNYVILLLNKYAKTTVKRILQDLSASIGLSISFGKFRGDNPILKIIESLEVNKKKTIKSFTKNEVITILDVFKNDKYLPEKALYNYSYYYNFVAFRFLTGTRPSEAIAVTWNDIFEKHKKTWLRINKRYVSNEIILGTKNGVDIRMFPVNDQLKDLIDSIPKIDNPNNLLFPSINKTYIDRKNFSTRIWKPLILKLVNEGLVKEYLTFYDVRHTFITHLCRSGKADLQTIANIVGNSVPTLIKNYLAVDDSLELPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S9</accession>
    <name>K9Z0S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218069.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52337">
        <property type="protein sequence ID" value="AFZ52337"/>
        <property type="gene ID" value="Cyan10605_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0181"/>
    <dbReference type="eggNOG" id="ENOG5033JMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202531_2_0_3"/>
    <dbReference type="OrthoDB" id="2100425at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="49" mass="5840" checksum="73F4FEF1AA14C61B" modified="2013-03-06" version="1">MAREYSLRVRLTKDEKSRLAYYAKCKNVSMSEIIQDYCKRLPKPPDTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T6</accession>
    <name>K9Z0T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218500.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0630"/>
    <dbReference type="EnsemblBacteria" id="AFZ52769">
        <property type="protein sequence ID" value="AFZ52769"/>
        <property type="gene ID" value="Cyan10605_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0630"/>
    <dbReference type="eggNOG" id="ENOG502ZF0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151879_0_0_3"/>
    <dbReference type="OrthoDB" id="1514974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="15758" checksum="FB3E8E5B1B005C14" modified="2013-03-06" version="1">MRLRKNTPIDLNCEYPCPCRRKGRLKPIILTEAMGCDKCQQIFVLAENKEYIEQLNPTYPYKKRWRWLGKRWISAQKPWQESYFLLGIVCFFFSVLVATPLLITLTGGFNLISGMMVGLIFLSVCFSLWFVYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V6</accession>
    <name>K9Z0V6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">Cyan10605_0656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218525.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0656"/>
    <dbReference type="EnsemblBacteria" id="AFZ52794">
        <property type="protein sequence ID" value="AFZ52794"/>
        <property type="gene ID" value="Cyan10605_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0656"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.691"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_3"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="134"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="37843" checksum="E8A51E3F4434320D" modified="2013-03-06" version="1">MTKLKIGLLFGGKSGEHQVSITSARAIALGFSVEENREKYEVIPLYIDQAGNWWGKEVAEGILKSGEPKPVEKDTKKNWHFPEECGEIEVFFPILHGPNGEDGTVQGLLTLMEVPFVGAGVLGSAVGMDKIAMKNAFACAGLPQVKYIAVNRSEIFSSPCVFPKVCDRLEAELGYPCFVKPANLGSSVGISKAKNRAELEKALDEAANLDRRVIVEAGVKAREVECAVLGNDNPSASVVGEITYNADFYDYTTKYTDGLASLIIPADIPNNISETIREMAIKAFLAVDSRGLSRVDFFYIPETGEVLINEINTLPGFTALSMYPKLWEASGIGFPQLLDKLITLAQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X8</accession>
    <name>K9Z0X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218124.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0240"/>
    <dbReference type="EnsemblBacteria" id="AFZ52392">
        <property type="protein sequence ID" value="AFZ52392"/>
        <property type="gene ID" value="Cyan10605_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0240"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.249"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092340_1_0_3"/>
    <dbReference type="OMA" id="CSHLRHE"/>
    <dbReference type="OrthoDB" id="1891199at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="23021" checksum="9A34F4BBF44E231A" modified="2013-03-06" version="1">MWDNFDSDPVFPPEQVLENRGRVAIFIDGSNLFYAALQLGVEIDYTKLLYRLTAGAKLLRAFFYTGVDRTNEKQQGFLLWMRRNGYRVIAKDLVQLPDGSKKANLDVEIAVDLMALVDYYDTAVLVSGDGDLAYAVDAVSYRGARIEVVSLRSMTSDSLINVADRYIDLDQIREDIQKTRKSNLTYDAFSPYHLIENRDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y4</accession>
    <name>K9Z0Y4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0726"/>
    <dbReference type="EnsemblBacteria" id="AFZ52861">
        <property type="protein sequence ID" value="AFZ52861"/>
        <property type="gene ID" value="Cyan10605_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0726"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136715_1_1_3"/>
    <dbReference type="OMA" id="TEAIFME"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15220" checksum="FF9F80607F1AF094" modified="2013-03-06" version="1">MSNRLFLDTTFIQAILNRRDQYHQSALKILPLMKNAQEIWTTEAILMEVGNALSKFDRLKVVSFIKQCYTTENIKIVNISSDVFREGLNLYKSRQDKEWGLIDCISFSVMVKQNITDALTTDHHFAQAGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z2</accession>
    <name>K9Z0Z2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217952.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0059"/>
    <dbReference type="EnsemblBacteria" id="AFZ52220">
        <property type="protein sequence ID" value="AFZ52220"/>
        <property type="gene ID" value="Cyan10605_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0059"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176251_0_0_3"/>
    <dbReference type="OMA" id="MNFSIQS"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="7">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10332" checksum="EBA45FCCA7EE0CB2" modified="2013-03-06" version="1">MKITPQAIYSLYSNAIRNPKYRNWIILGTLIYVLSPIDISPDIFPLAGQIDDFLLLSIMAIEVTQMVFNSQKKEEEKPTEKTVDVDAVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z119</accession>
    <name>K9Z119_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="5">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0724"/>
    <dbReference type="EnsemblBacteria" id="AFZ52859">
        <property type="protein sequence ID" value="AFZ52859"/>
        <property type="gene ID" value="Cyan10605_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0724"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.759"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_6_2_3"/>
    <dbReference type="OMA" id="NWNYTAG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003913">
        <property type="term" value="F:DNA photolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="491" mass="57630" checksum="68E1ADAB9447B486" modified="2013-03-06" version="1">MGEIEIMNTALIWFRNDLRIHDHAILARIAEGDYQRIIPFYCFDDRQFQTTSFGFAKTGKYRAKFLIESVADLRESLQKLGTDLIVRKGIPEQIIPDIAKQYNVTEFYFSQEATEEEIKVEKRLIKALKQLHIQVKSCWQSTLYQPDDLPFSIENLPDLFTHFRKQIEKKSIVEECFETPKKLPPIPPIDTGNIPILSDLGLENFEVSQLAVLPFKGGETEAIKRLKSYFWEKDCLKVYKETRNGMLGGDYSSKFSPWLALGCLSPRYIYEEVEKYEQERVKNDSTYWLIFELLWRDFFRFTAVKYGNRLFYPSGIQNISIPWQENWLIFEAWCEGQTGYPLIDANMRELKTTGFMSNRGRQNVASFLTKNLGINWQMGAEWFESLLIDYDVCSNWGNWNYTAGIGNDARGFRYFNIPKQSKDYDYRGDYLRHWLPEIASIRGDKIHEPWKLSRGEQQQFRVQLGVDYPAPIVDFFKSVKYNEKVYLSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z189</accession>
    <name>K9Z189_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218062.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0173"/>
    <dbReference type="EnsemblBacteria" id="AFZ52330">
        <property type="protein sequence ID" value="AFZ52330"/>
        <property type="gene ID" value="Cyan10605_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0173"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.181"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_2_0_3"/>
    <dbReference type="OMA" id="WVRIAFE"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15795" checksum="916AAE1C6F32581B" modified="2013-03-06" version="1">MLNSDINFPLPDGTKPDYDGLVRFLIEPLLESPELLNFDCELVPSTKRVWIRLAFEENDKGRIYGRGGRNIQAVKTVLQTAANIVGDTLYLEIYDEQGRNRSRNSRPPITSSSPNKESGDAYSKKPVRRRRRTIKPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A6</accession>
    <name>K9Z1A6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplS</name>
        <name evidence="5" type="synonym">rpl19</name>
        <name evidence="7" type="ordered locus">Cyan10605_0194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0194"/>
    <dbReference type="EnsemblBacteria" id="AFZ52350">
        <property type="protein sequence ID" value="AFZ52350"/>
        <property type="gene ID" value="Cyan10605_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0194"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.204"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_0_3"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="15462" checksum="5B0782175AC8936E" modified="2013-03-06" version="1">MSINANAIIQSIEAEYLKDKDSIPTIHVGDTIKVGVRIQEGGKERVQPFEGTVIAMRHGGINKTITVRRIFQGVGVERVFLIHSPIVANIQVLRRGKVRRAKLYYLRDRVGKATRIKQRFDRPIDTVKTTKSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C2</accession>
    <name>K9Z1C2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ordered locus">Cyan10605_0215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218102.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0215"/>
    <dbReference type="EnsemblBacteria" id="AFZ52370">
        <property type="protein sequence ID" value="AFZ52370"/>
        <property type="gene ID" value="Cyan10605_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0215"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.225"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_4_3"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="429" mass="48440" checksum="C15969A3E7981961" modified="2013-03-06" version="1">MKRVLSIILGGGAGTRLYPLTKLRAKPAVPLAGKYRLIDIPISNCINSEILKIYVLTQFNSASLNRHISKAYNFSGFSDGFVEVLAAQQTKENPDWFQGTADAVRQYLWLFEEWDVDEYIILSGDHLYRMDYSKFVQHHRDTNADITISVVPIDEQKASAFGLMKIDDNGRIISFSEKPEGEALKQMAVDTSILGLNPEQAKEKPYIASMGIYVFKKEVLEKLLRQNPNQTDFGKEVIPFAAKDHRIQAYLYKGYWEDIGTIEAFYDANLALTNQPQPDFSFYDEKAPIYTRSRYLPPTKLLNSNVTQSIIGEGCIIKECRINHCVLGVRTRIENNCIVEDTLVMGADFYEPFSVRKSKIEQGSVPVGIGANSTIRRAIIDKNARIGQNVIITNKDRVEEANREDEGFLIRNGIIVIIKNAVIPDNTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D0</accession>
    <name>K9Z1D0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218742.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0881"/>
    <dbReference type="EnsemblBacteria" id="AFZ53011">
        <property type="protein sequence ID" value="AFZ53011"/>
        <property type="gene ID" value="Cyan10605_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0881"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.926"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_3"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="325" mass="36344" checksum="35A1B54002520D47" modified="2013-03-06" version="1" precursor="true">MFYIIKRLLQGLLTLLLASILSFAIIQLAPGDYLDNLRQNPTISQETIEELKIRFGLDKSAIEQYWLWFKQVITHFDFGESFVYSRSVSSLILERIPATLLLACSSIIITWAIALPLGIISAVKQNTFTDRFLRVISYFGQGFPSFITALLLLILAQYLSPLFPVGGMTSINHAELSTGGKILDIAWHMILPTIALSITSFAGLQRLTRGQLLDVLRQDYIQTARAKGLPENKVIYVHALRNAINPLITLLGFEFASLLSGSFIAEYFFNWPGLGRLILQAVQAQDLYLVMASLMMGATMLIIGNLFADILLTVVDPRIRLDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E4</accession>
    <name>K9Z1E4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218127.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0243"/>
    <dbReference type="EnsemblBacteria" id="AFZ52395">
        <property type="protein sequence ID" value="AFZ52395"/>
        <property type="gene ID" value="Cyan10605_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0243"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.252"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078529_0_0_3"/>
    <dbReference type="OMA" id="PRTFWIE"/>
    <dbReference type="OrthoDB" id="1256816at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="30071" checksum="8ADE85B11FE33DFF" modified="2013-03-06" version="1" precursor="true">MHHRIVTKVILALFVGLISLGTWFIFPTHPAYAVNNPELLPEEVTPVVDLANYLPDLQQESLIEDIESFEQETGWKLRVLTQYERSPGRAVINFWGLDDRSILLVADGKGGNLLAFSVGDDVYDLLPRTFWIELQTRFGNMYYVREHGENNAIVHTIDTVKNCLADGGCLVVPGLPKEQWILTLVTSVVGGVIFGLAALPRKEGQVFAWQWVLIISPLWGILFFAFGMGPVVSRTSEWLPLFRNIIGFALGALVAYFSPLLNQQSPSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G3</accession>
    <name>K9Z1G3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Circadian clock protein KaiC</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218740.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0879"/>
    <dbReference type="EnsemblBacteria" id="AFZ53009">
        <property type="protein sequence ID" value="AFZ53009"/>
        <property type="gene ID" value="Cyan10605_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0879"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.924"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_1_3"/>
    <dbReference type="OMA" id="MPGEEHL"/>
    <dbReference type="OrthoDB" id="271085at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013503">
        <property type="entry name" value="Circadian_KaiC_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02655">
        <property type="entry name" value="circ_KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="256"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="506" mass="56480" checksum="EFE1830F0CCCEC3A" modified="2013-03-06" version="1">MSQGAELETDYIEKLETGIPGFDFLAEGGLPKGRATLISGTAGSAKTVFACQFLVEGIKKGENGVFITFEESPKAIRKNMRGFDWNIKEWEENRQWAFVDASPQPGETPMVSGKYDLGALIARIEYAIRKYSAQRVSLDSLGAIFSHLADSAQVRSDLFRLASALRELEVTAIMTAERTEEYGEISRFGVEEFVADNVVILRNVLNDEKRRRTIEILKYRGTDHQKGEYPFTIIKGKGAVIIPLSAIELEQHSSNIRITSGSKELDKMCGGGFFRDSIILVSGATGTGKTLMVTEFMAGGVENNERCLVFAFEESREQLFRNATGWGVDFEKMEKEGKLKVVCRYPETTGLENHLINMKDTIQTFKPNRVAVDSLSALERVSTLKGFREFIIGLTSFIKQQEIGGLFTSTTPTLLGGSSITEAHISTITDSIILLRYVEMYGEMRRGITVLKMRGSMHDKDIREFTIDNRGMHIGHPFRNVTGILAGTPMYTTQSEVERLTNLFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H1</accession>
    <name>K9Z1H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0275"/>
    <dbReference type="EnsemblBacteria" id="AFZ52425">
        <property type="protein sequence ID" value="AFZ52425"/>
        <property type="gene ID" value="Cyan10605_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0275"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.285"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091338_1_1_3"/>
    <dbReference type="OMA" id="NRRPFSN"/>
    <dbReference type="OrthoDB" id="1709200at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18174" checksum="4EB05C1DED2695F8" modified="2013-03-06" version="1">MNSDYNRKTQYTTITKEYFADTHYGLLKLHPSASVMEIRRAYRELSKFYHPDTTDLPPEEAKQKFQRLNEAYGVLANPETRLKYDLQIGYSRWNVIQSPYDFSRANEYDSSKASYLDPSDRPLSAGELFALLLMGLTIFGCMILAFCLAWWRTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N6</accession>
    <name>K9Z1N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease, beta subunit</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218368.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0495"/>
    <dbReference type="EnsemblBacteria" id="AFZ52637">
        <property type="protein sequence ID" value="AFZ52637"/>
        <property type="gene ID" value="Cyan10605_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0495"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.525"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_1_1_3"/>
    <dbReference type="OMA" id="FYEVNDA"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="9875" checksum="21B1C101B2BF02A3" modified="2013-03-06" version="1">MIPGEIFTPEGSIELNQGRETLKITVANTGDRPIQVGSHFPFAKVNSALRFDRDKTISMRLNIPAGTAIRFEPGDEKEVELVKTQGTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z250</accession>
    <name>K9Z250_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219000.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1149"/>
    <dbReference type="EnsemblBacteria" id="AFZ53271">
        <property type="protein sequence ID" value="AFZ53271"/>
        <property type="gene ID" value="Cyan10605_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1149"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1216"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_1_1_3"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="11373" checksum="DF0F20ADF24CEFCA" modified="2013-03-06" version="1">MIESFEWDEKKNKINQDKHNVSFELAQLAFLDKNRIIVKDCSHSINEDRFFCIGKVNEGIITVRFTYRHQRIRIFGAGYWRKGNKLYEQQNKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z262</accession>
    <name>K9Z262_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0336"/>
    <dbReference type="EnsemblBacteria" id="AFZ52483">
        <property type="protein sequence ID" value="AFZ52483"/>
        <property type="gene ID" value="Cyan10605_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0336"/>
    <dbReference type="HOGENOM" id="CLU_965473_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="33744" checksum="E2F59D73A3F56388" modified="2013-03-06" version="1">MASSWGIDDYFIAKLYQTENFHGLSNRIFFWSPRFFSEIVLYVYYRLVPFLGKPLTGGINLITWLFLISSIFLFIKETLKKHSLVRQDVYIKLLIPLFITFVLLNYFLLSQNPGSMFYESVISVPYVSTLAGIIFNLNFFINQSNSISISRFYLLYLIIFGVITSSSWEMGAIYQLLFSTCLFFSLILTTISTRFYDLPFHSLHTFSRWTLSIANLIPFSLSLYILFLLKSNRLEVVELAQIESPLKGNFQNSLSSSFIQFFREIFFLNDVSGEAQVNFFFFYIFYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z268</accession>
    <name>K9Z268_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase subunit C</fullName>
            <ecNumber evidence="2">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218219.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0341"/>
    <dbReference type="EnsemblBacteria" id="AFZ52488">
        <property type="protein sequence ID" value="AFZ52488"/>
        <property type="gene ID" value="Cyan10605_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0341"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.357"/>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052147_1_0_3"/>
    <dbReference type="OMA" id="PGCVAQG"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="32672" checksum="8915EFBCDD4E63FF" modified="2013-03-06" version="1">MLRYAYFPGCVAQGACHELHQSTIAISQALDIELIELKKAACCGSGTYKEDSQLLEDTVNARNIALAESLNLPLLTHCSTCQGVIGHVDERLKEAKENDVEYFNQVNGFLKKENCSPYQGTTEVKHILWALISDYGLDALQAKVVKSLKGLKCAAFYGCYLLRAQKHLPFDNPFNPQSLEQVFSVLGATPVFYEGRIKCCGWPLSSYATEQSFKMAGKNLLDAINNGADCIVTPCPLCHLNLDSRQPEVAKVIQKKLDLPILHLPQLVGLALGIEPEKLGLNNHVVSTAKVLHLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z284</accession>
    <name>K9Z284_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolycopene isomerase</fullName>
            <ecNumber evidence="7">5.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene</text>
            <dbReference type="Rhea" id="RHEA:30971"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:62466"/>
            <dbReference type="EC" id="5.2.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Plastid</location>
            <location evidence="5">Chloroplast membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218978.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z284"/>
    <dbReference type="STRING" id="755178.Cyan10605_1127"/>
    <dbReference type="EnsemblBacteria" id="AFZ53249">
        <property type="protein sequence ID" value="AFZ53249"/>
        <property type="gene ID" value="Cyan10605_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1127"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1193"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_4_1_3"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046608">
        <property type="term" value="F:carotenoid isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014101">
        <property type="entry name" value="CrtISO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02730">
        <property type="entry name" value="carot_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="496" mass="56028" checksum="AE3781314E98E604" modified="2013-03-06" version="1">MNQYDVIVIGSGIGGLVTATQLAAKGVKVLVLERYLIPGGSAGYFESQGYRFDVGASMIFGFGTEGTTNLLTRALDAVNMKMETIPDPVQIHYHLPNNLDLKVHRDYDLFLEELYNYFPDEKEGIRKFYDECWAVFNALNSMELLSLEEIRYLTRVFFQKPLACLSLVKYLPLNVGDVARKYIKNPELLKFIDMECYCWSVVPADLTPMINAGMVFSDRHYGGINYPKGGVGKIGETLAEGLEKLGGEIKYQARVTEIIVENHEAIGVRLANGKEYYAQRIVSNATRWDTFEKLIENKKPKKEVKWQQNYRQSPSFLSLHLGVEAKVLENNPECHHIILEDWNNLEAEQGTIFVSIPTLLDRSLAPSGYHIIHTFTPSSMDYWQGLTPKQYEFKKEEAAGRLIERLEKIFPGLDAGLDYMEIGTPRTHRRFLGRINGTYGPIPARRLLGLLSMPFNRTSIKNLYCVGDSTFPGQGLNAVAFSGFSCAHRIAVDLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A8</accession>
    <name>K9Z2A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron permease FTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219008.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1157"/>
    <dbReference type="EnsemblBacteria" id="AFZ53279">
        <property type="protein sequence ID" value="AFZ53279"/>
        <property type="gene ID" value="Cyan10605_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1157"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077905_0_1_3"/>
    <dbReference type="OMA" id="WYGTLLK"/>
    <dbReference type="OrthoDB" id="2018349at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="294" mass="33605" checksum="079C872CC79CC2D5" modified="2013-03-06" version="1">MYWNIFLPVFVIILRNIFPISLLLAIIFACFQRIEHSGYFRQIYLGISGGIVASILVGSVISQGINNIDSTSNNAWIFTPLILNIFVFIAISLLIWFILWFSQQANFWQNLGSTNELLMGKNLRLTIFSLALFLVLIKGINIFLLLNVMPENNSTYVNLAVIASLLLTVLMTLAFVYLQTRLTNHVFFRIAGIFLILVTGGLIIDSLYNLDESLLFINELDTTANWCLFEQNSCLLGSILWSSHEILPEDKFPFILMKIVFGYHDIVYIIPLAIYLLFVFIVGKFYFQNLKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E2</accession>
    <name>K9Z2E2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b'</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b'</fullName>
            <shortName evidence="11">F-ATPase subunit b'</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF2</name>
        <name evidence="11" type="synonym">atpG</name>
        <name evidence="14" type="ordered locus">Cyan10605_0769</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218633.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0769"/>
    <dbReference type="EnsemblBacteria" id="AFZ52902">
        <property type="protein sequence ID" value="AFZ52902"/>
        <property type="gene ID" value="Cyan10605_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0769"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.810"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_9_0_3"/>
    <dbReference type="OMA" id="PLMAIQF"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01399">
        <property type="entry name" value="ATP_synth_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034679">
        <property type="entry name" value="ATP_synth_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17689" checksum="D1164932ACC3D2AF" modified="2013-03-06" version="1">MTQWILLAAETAESGGLFDIDATLPLMAIQFLILATILNALFYKPLGKAIDERAGYVQGQLDQAKKQKQDAIALAQQYEQELREVRKESQNVIAQAQAEAQKIVSEQVQQAQQEVIAERQKASEQIEAERKEALSALEKQVKALSHQIVEKVIGAEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G1</accession>
    <name>K9Z2G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recO</name>
        <name evidence="9" type="ordered locus">Cyan10605_0611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218481.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0611"/>
    <dbReference type="EnsemblBacteria" id="AFZ52750">
        <property type="protein sequence ID" value="AFZ52750"/>
        <property type="gene ID" value="Cyan10605_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0611"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.644"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_0_0_3"/>
    <dbReference type="OMA" id="PLGENDR"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="271" mass="31242" checksum="4208A5F6A50772CA" modified="2013-03-06" version="1">MNANFQTTGIILQKKPFGENDLLISFLSPELGLKKAIAPNGRLYKSTLRGRTELLMVNDFFLIKGRNLDRILQIEGQISYGQLNSNIGKLTISQYLAELVLHLAHEQPQKELYMLFLEHLRRIDSLTDNEQLFAYLAQAVFHLLAISGIAPEIYHCVHNQRQIQPNFEQPYWRVGFTFQGGGVTEYVKSSYSSHYYQINDHLNAVELALLQSLPKPSLLSDLREIIPFNCDDLVIQKSWMRIERILKNYLEFHLDCKMRSAEVIADILIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M5</accession>
    <name>K9Z2M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218359.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0486"/>
    <dbReference type="EnsemblBacteria" id="AFZ52628">
        <property type="protein sequence ID" value="AFZ52628"/>
        <property type="gene ID" value="Cyan10605_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0486"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.515"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_3"/>
    <dbReference type="OMA" id="FPQWGAY"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="242" mass="25650" checksum="3A567005F724A1AE" modified="2013-03-06" version="1">MENAPNRLRAIITGASSGIGKATTLAFASSGIDLCLVSRDQAKLQQVADLASEYGGQVKIVSTDLANLSTVQTVIKAIAEDFGPIDILVNNAGMGYTNLLKDTSLEDWQKVLDLNLTSVFQCVMGILPSMRERGKGTIVNVASIAASNFFPEWGLYSVSKSALVTFGECLAIEERANGIRVTTISPGAVNTPIWETETVQAYFDKSAMLTPETVAQTILHTVLLPQGAVVEKLTIAPSGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N9</accession>
    <name>K9Z2N9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="7" type="synonym">rpl31</name>
        <name evidence="8" type="ordered locus">Cyan10605_0496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218369.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0496"/>
    <dbReference type="EnsemblBacteria" id="AFZ52638">
        <property type="protein sequence ID" value="AFZ52638"/>
        <property type="gene ID" value="Cyan10605_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0496"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.526"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_1_2_3"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="8968" checksum="7F2A9FCB077A8105" modified="2013-03-06" version="1">MPKEGIHPQWYPDAKVICNGEEVMRVGSTQPEINVEVWSGNHPFYTGTQKIIDTEGRVDRFLRKYGMLGKQEKKDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z2</accession>
    <name>K9Z2Z2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromophore lyase CpcS/CpeS</fullName>
            <ecNumber evidence="3">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpcS</name>
        <name evidence="4" type="ordered locus">Cyan10605_0823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CpcS/CpeS biliprotein lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218686.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0823"/>
    <dbReference type="EnsemblBacteria" id="AFZ52955">
        <property type="protein sequence ID" value="AFZ52955"/>
        <property type="gene ID" value="Cyan10605_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0823"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.866"/>
    <dbReference type="eggNOG" id="ENOG502Z8E6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096258_0_0_3"/>
    <dbReference type="OMA" id="LWFASPN"/>
    <dbReference type="OrthoDB" id="1672344at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017009">
        <property type="term" value="P:protein-phycocyanobilin linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01459">
        <property type="entry name" value="Chrphore_lyase_CpxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018536">
        <property type="entry name" value="CpcS/CpeS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09367">
        <property type="entry name" value="CpeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="22339" checksum="347B41963178A0A9" modified="2013-03-06" version="1">MDGLTFFQNSAGKWRSQRTTHHLPFRRAETGGSEIKVEHLEQNDPKIKEICEMHSFDPSLSVGGSYVTWDGAMQWDKENENHQGETVFALIPNQENPRQGKLLRERGYAEIVPVAGEYYLDHEDALILSTEYETMTIHEKFWFVNDNIRMRTSTVQRFGGFNTATFCIEVREADNQVIAEEIKPLLNTPSITGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z314</accession>
    <name>K9Z314_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219278.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1438"/>
    <dbReference type="EnsemblBacteria" id="AFZ53549">
        <property type="protein sequence ID" value="AFZ53549"/>
        <property type="gene ID" value="Cyan10605_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1438"/>
    <dbReference type="eggNOG" id="COG3463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492502_0_0_3"/>
    <dbReference type="OMA" id="IFNQVFW"/>
    <dbReference type="OrthoDB" id="1385011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="531" mass="60624" checksum="B4677E6F88CF2EF9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z317</accession>
    <name>K9Z317_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HerA-ATP synthase, barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218711.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0848"/>
    <dbReference type="EnsemblBacteria" id="AFZ52980">
        <property type="protein sequence ID" value="AFZ52980"/>
        <property type="gene ID" value="Cyan10605_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0848"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.891"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513616_0_0_3"/>
    <dbReference type="OMA" id="MITRRIH"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAS-barrel" evidence="2">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="162"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="566" mass="63931" checksum="2D31230F7EA79095" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z337</accession>
    <name>K9Z337_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219348.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1511"/>
    <dbReference type="EnsemblBacteria" id="AFZ53621">
        <property type="protein sequence ID" value="AFZ53621"/>
        <property type="gene ID" value="Cyan10605_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1511"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1604"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425573_0_0_3"/>
    <dbReference type="OMA" id="HDNYYDI"/>
    <dbReference type="OrthoDB" id="344684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025193">
        <property type="entry name" value="DUF4114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13448">
        <property type="entry name" value="DUF4114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4114" evidence="1">
        <location>
            <begin position="594"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="645" mass="69488" checksum="42DDC69CD0A36CB8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z364</accession>
    <name>K9Z364_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1537"/>
    <dbReference type="EnsemblBacteria" id="AFZ53646">
        <property type="protein sequence ID" value="AFZ53646"/>
        <property type="gene ID" value="Cyan10605_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1537"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261594_0_0_3"/>
    <dbReference type="OMA" id="RTFIKGY"/>
    <dbReference type="OrthoDB" id="19646at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="PTHR21529"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1325" mass="156685" checksum="B3DB49199636F3E3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C8</accession>
    <name>K9Z3C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218958.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1105"/>
    <dbReference type="EnsemblBacteria" id="AFZ53227">
        <property type="protein sequence ID" value="AFZ53227"/>
        <property type="gene ID" value="Cyan10605_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1105"/>
    <dbReference type="eggNOG" id="ENOG502ZCG7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079645_0_0_3"/>
    <dbReference type="OMA" id="HLCTQGY"/>
    <dbReference type="OrthoDB" id="1724038at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="34801" checksum="97A350FCAA492A7E" modified="2013-03-06" version="1">MTRSIKQLRNDLGILNVKIKDLATELQSLYQDYFPQLIAVVKRQLILATYQVCTQKYPSAFLALSYQDKVNLQKHIKDLHSFFPKDLYGKISEIEIIDNIFLHNLKSRILASVPYQNDVTLLTESKENETETFDKDNILEGNHQNDSLLKDDNLLEICPENLIQLQVEVDDAIEECLIKLSHQVNKYLQEIGILPKNIPAKILEVALQAEENTSLISGAPNLLSLLIEKDDKSEDVNITPVVALCLRINEIEFNDPLLNQNRQKISRIFQSLNNLDDEYQNKYQQYQIALAESAWRSSWIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L5</accession>
    <name>K9Z3L5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ordered locus">Cyan10605_1688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219518.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1688"/>
    <dbReference type="EnsemblBacteria" id="AFZ53791">
        <property type="protein sequence ID" value="AFZ53791"/>
        <property type="gene ID" value="Cyan10605_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1688"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1791"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_3"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="14"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="409"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="638" mass="71866" checksum="77AF055AD72EC320" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M2</accession>
    <name>K9Z3M2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219071.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1223"/>
    <dbReference type="EnsemblBacteria" id="AFZ53342">
        <property type="protein sequence ID" value="AFZ53342"/>
        <property type="gene ID" value="Cyan10605_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1223"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1291"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_0_1_3"/>
    <dbReference type="OMA" id="WYTTRER"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="248"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="898" mass="100802" checksum="0457EB70E2F50E28" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N9</accession>
    <name>K9Z3N9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218734.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0873"/>
    <dbReference type="EnsemblBacteria" id="AFZ53003">
        <property type="protein sequence ID" value="AFZ53003"/>
        <property type="gene ID" value="Cyan10605_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0873"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.918"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_3_3"/>
    <dbReference type="OMA" id="KLYCYRV"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="36079" checksum="3D16F13B912BC72F" modified="2013-03-06" version="1">MLQLPKKLQPKQPLASLEESYEYCRQVTAKYSKTFYLGTLLMPKEKRSAIWAIYVWCRRTDELVDGPQAKLTTPETLDLWEQQLESVFAGQPIDDPDVALVDTLKRYPMDIQPFKDMIAGQRMDLYRNRYETFNDLYLYCYRVAGTVGLMSSAVLGIDNSYKNAPWYDKTVYIPEKEAIALGIANQLTNILRDVGEDIGRGRIYLPLEDLERFNYTQEDLFNKVIDERWYDLMKFQINRAKEYYQQAESGIKALNPDGRWPVWSALMLYQGILDVIAKNNYDVFNRRAFVPTPNKIIYLPVAWLRAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W1</accession>
    <name>K9Z3W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219161.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1317"/>
    <dbReference type="EnsemblBacteria" id="AFZ53432">
        <property type="protein sequence ID" value="AFZ53432"/>
        <property type="gene ID" value="Cyan10605_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1317"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1390"/>
    <dbReference type="eggNOG" id="COG4671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044082_0_0_3"/>
    <dbReference type="OMA" id="SNFGWDF"/>
    <dbReference type="OrthoDB" id="700931at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="360" mass="40682" checksum="4C6A414734508922" modified="2013-03-06" version="1">MSRPVLYLAITNHGFGHAVRMATVASQVQKLNPDILLVVVTTAPRWLLESYIEGDFIHRLRAFDVGVIQSDSLTMDLGATLESMKEYCQKEAEIVAGEVNFIRLNKVGLILADIPAMASTIAQKADIPCWMMSNFGWDFIYQAWGDDFQEVTHWLRSRYEKVERLFRLPLAEDMSSFPLLEDVGLTGGNPRYSCEVLRDKFELIKPKEKTVLLTFGGLGLEAIPYENLASFSDWQFITFAKNAPDLPNLLRIDGHSLRPVDFMPVCGKVVSKPGYSTFAESLRLDVPVISITRDGFAEAQILLDGLRNYGYHRIVNYADFFEGNWDFLKQDAIAPLTNNKLDKNGTEFIAQEIVNFFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z0</accession>
    <name>K9Z3Z0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219014.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1163"/>
    <dbReference type="REBASE" id="58408">
        <property type="entry name" value="M.Cap10605ORF1163P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53285">
        <property type="protein sequence ID" value="AFZ53285"/>
        <property type="gene ID" value="Cyan10605_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1163"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1230"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_10_1_3"/>
    <dbReference type="OMA" id="WRKANPM"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="46707" checksum="1E0A40394938C38E" modified="2013-03-06" version="1">MEKIIKGNCLEELKNIDSEIVDLIYLDPPFFTQKKHSLTTRDNRINYQFYDIWHSLNDYLFMMKKCLIECKRILKKTGNIFLHCDKSASHHLRVLLDQIFLPENFRSEIIWSYKRWSNSKKGLLNSHQTIYFYSKTYDFKFNTIYTDYSPTTNVDQIWQLREKNDYGKSVYKKDKNGNIILAQEKKGVPLSDVWEIPFLNPKAKERVGYPTQKPVLLLQQIINISTDEGDLVLDAFCGSGTTCVAAKSLHRNFIGIDISEDAIALTQKRLNEMIITNSKLLEKGKTSYIEKSEDELFLLKSINAIPVQRNNGIDGFLKRQFNEKPIPVRIQKKDETLENAIASINNSEQAKKSDLKIVIQTNNYHQLFPLEDEKIIVIKSSELLIKEELQKVNMMVYNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z441</accession>
    <name>K9Z441_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219241.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1400"/>
    <dbReference type="EnsemblBacteria" id="AFZ53512">
        <property type="protein sequence ID" value="AFZ53512"/>
        <property type="gene ID" value="Cyan10605_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1400"/>
    <dbReference type="eggNOG" id="ENOG5032S45">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153663_1_0_3"/>
    <dbReference type="OMA" id="YAKENIC"/>
    <dbReference type="OrthoDB" id="2039236at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025578">
        <property type="entry name" value="DUF4359"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14271">
        <property type="entry name" value="DUF4359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="15061" checksum="15688DDB1EF2C612" modified="2013-03-06" version="1">MNPLFLEERKFPRVLLAVGGGFFLIMGIILTLTNPNSTKYEKFATEELVRYAKENICPAQSSNLEEMIKSQVCNLIVDTGKNKIPQLIASNTKRNNYLLLSLYTTNLYIYQFETIAVFNNFYVINAQKLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z467</accession>
    <name>K9Z467_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53929">
        <property type="protein sequence ID" value="AFZ53929"/>
        <property type="gene ID" value="Cyan10605_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1827"/>
    <dbReference type="eggNOG" id="ENOG502ZE7N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212012_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5464" checksum="F77E6F736DC4C3BD" modified="2013-03-06" version="1">MKAKFNNNTSNISSIGQQARLLMVDNRQRKSNRQATMLERASEQVGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z472</accession>
    <name>K9Z472_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219271.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1431"/>
    <dbReference type="EnsemblBacteria" id="AFZ53542">
        <property type="protein sequence ID" value="AFZ53542"/>
        <property type="gene ID" value="Cyan10605_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1431"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1512"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132085_0_0_3"/>
    <dbReference type="OMA" id="GPKIQIR"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14438" checksum="EC243C407F0DC17A" modified="2013-03-06" version="1" precursor="true">MITLTLLHPLKSVAVQKWNFDPNSVIRIGRANDNDVVLYSAVVSRHHLEIRPRGKDWALINLGSNGTFINGKKINKVLVKHGMVIRLASSGPKIKITLDDSVDSPTSKDSQQPKRRAISSKDISKETVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z498</accession>
    <name>K9Z498_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ordered locus">Cyan10605_1059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53183.1"/>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
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    <dbReference type="EnsemblBacteria" id="AFZ53183">
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    <dbReference type="PATRIC" id="fig|755178.3.peg.1120"/>
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        <property type="reaction ID" value="UER00942"/>
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        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PurK"/>
    </dbReference>
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        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="106"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="379" mass="42585" checksum="6DBA70791A6A8543" modified="2013-03-06" version="1">MTKNVGVIGGGQLAWMMALVAPQENIKIYIQTPHETDSAVCLGERTIFAPVDDVSATAELAKYCDVITFENEFVDLEGLQSLVTEGVCFYPRLTSLSPLLDKFDQRSFFQSQGFPVPRFSLYESDSDFQSFSFPLVLKARRHGYDGQGTVIVKSPLELQSALEKFKQTPLLIEEFVPFEKELAIMAARSATGEIKVYPVAETYQENQVCRWVIAPALINQDITEKISAIASKLLVSLDYVGILGIELFMKNNGEVLINEVAPRTHNSGHYTLDACETSQFAMQLQTITGKKLGNTRLKSSGAVMINLLGYESAQSEYLPQRKEIEQLGAFVHWYGKTESRQGRKLGHVTVLLDEKSPEKMYHQAQMMIEKVESIWYPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V5</accession>
    <name>K9Z4V5_CYAAP</name>
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        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1505"/>
    <dbReference type="EnsemblBacteria" id="AFZ53615">
        <property type="protein sequence ID" value="AFZ53615"/>
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    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1505"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1596"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="284"/>
            <end position="539"/>
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        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="545" mass="61186" checksum="AB60DE554BF79DDB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W2</accession>
    <name>K9Z4W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54201">
        <property type="protein sequence ID" value="AFZ54201"/>
        <property type="gene ID" value="Cyan10605_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2112"/>
    <dbReference type="HOGENOM" id="CLU_3342771_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="37" mass="4224" checksum="10EF683796844D9A" modified="2013-03-06" version="1">MVGIAHPTRFINRETGILPVAYLSRSVEIKLNKVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W8</accession>
    <name>K9Z4W8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219509.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1677"/>
    <dbReference type="EnsemblBacteria" id="AFZ53782">
        <property type="protein sequence ID" value="AFZ53782"/>
        <property type="gene ID" value="Cyan10605_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1677"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1780"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_3_3"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="32648" checksum="7FE78F413DEAFB5E" modified="2013-03-06" version="1">MPYARTISTIVAIALALIMIILGGLYFTICFGVIVFLAQLEYFRLVKAKGIEPAAKTTLVVSQLLLITATFVPNLTDATFALAGALICFYLLFQPKLATIADISTSILGLFYAGYLPSYWIRLRVSLDQNTAYAQSIPNIHNLPLDGYFPIHPFDISSFPDALKLTFMAMACIWAADIGAYLIGKNFGKTKLSHISPKKTVEGSLSGITGSILVGLVGAWLLQWDAWIITGSFLGLLIGVVSLLGDLMESMMKRDAGVKDSGQLIPGHGGILDRTDSYVFTAPLVYYFVTLLLPLFSHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z6</accession>
    <name>K9Z4Z6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219377.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1541"/>
    <dbReference type="EnsemblBacteria" id="AFZ53650">
        <property type="protein sequence ID" value="AFZ53650"/>
        <property type="gene ID" value="Cyan10605_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1541"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119980_0_0_3"/>
    <dbReference type="OMA" id="QWRQEIT"/>
    <dbReference type="OrthoDB" id="1983924at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17640" checksum="405DDC7BB0F57B1A" modified="2013-03-06" version="1">MLHLAEVIRDTDTGKFLLNLLAVEESKLQWTFCNNQYIPLDNDDDNFKEGLLLLVELNNQGQILRCQSAKDWILNLLKEYLIEGNFRSNININIPEEEARLEKWRQELTSQSQDLTRIRLEVETRREELQELEQTLSWEKEKLKSQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z567</accession>
    <name>K9Z567_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 4 prepilin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220009.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2198"/>
    <dbReference type="EnsemblBacteria" id="AFZ54284">
        <property type="protein sequence ID" value="AFZ54284"/>
        <property type="gene ID" value="Cyan10605_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2198"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465915_0_0_3"/>
    <dbReference type="OMA" id="QITFFGK"/>
    <dbReference type="OrthoDB" id="1916683at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="2">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="173" mass="19779" checksum="DED7E5A919AAD813" modified="2013-03-06" version="1">MKDYHRSLLKKVISNLPTNYHYFGQKGFNLLELLIVTFILGILAAIAVPNLLKQVDKARYTQAIMDMDCIADDVRTYHLENGVFPKDVGSNTKPSGVNCFPRRNIDKIPFNSRYDYESWNGGSQKCYIQITFFGKNGVRNSPTNRVVFSEPGLYYDYDDDLILTLGIFDTPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D3</accession>
    <name>K9Z5D3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219679.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1850"/>
    <dbReference type="EnsemblBacteria" id="AFZ53952">
        <property type="protein sequence ID" value="AFZ53952"/>
        <property type="gene ID" value="Cyan10605_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1850"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1963"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_3"/>
    <dbReference type="OMA" id="IMITARV"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="223" mass="25821" checksum="E44D4872EC6CF969" modified="2013-03-06" version="1">MSKILVVEDEQKLAKFLELELQYEGYEVAIAPDGKEGLKVAQKINPDLILLDWMLPQMSGFDVCRQLRSLGCMIPIILLTARDEINDRVAGLDAGADDYIVKPFGIEELLSRLRVHLRKSNEEDPDELHFLDLSLNRRTREVKRGDRIIDLTATEYDLMEYLISHPRQVLTRDQILEKVWGYDFGGDSNIIEVYVRYLRLKLESNKEKRIIQTVRGVGYVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F2</accession>
    <name>K9Z5F2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ordered locus">Cyan10605_1519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219355.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1519"/>
    <dbReference type="EnsemblBacteria" id="AFZ53628">
        <property type="protein sequence ID" value="AFZ53628"/>
        <property type="gene ID" value="Cyan10605_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1519"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1614"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078499_1_1_3"/>
    <dbReference type="OMA" id="NRETSAH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="222" mass="24378" checksum="9E9EAFBC573CD81F" modified="2013-03-06" version="1">MSNFLGKLKDIIGGGQGDYQYYEEEIESMTTQDLPPSDIEMNEVAIPQTEAPVTPPLSSSRRRPRDNRETSAHKSSDVSSSYLDSGNFSSNLPNNVIGMPGVNNIVNEVVVIEPHSFDEIPQVIQTLKEQRSVILNLNVMEAEEAQRAVDFVAGGTYAIDGHQERIGESIFLFTPRNVKVSTISGKSYQNGNTKIGSEGLTKSFDALWNETSSTELTDSMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V1</accession>
    <name>K9Z5V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220289.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2485"/>
    <dbReference type="EnsemblBacteria" id="AFZ54566">
        <property type="protein sequence ID" value="AFZ54566"/>
        <property type="gene ID" value="Cyan10605_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2485"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2634"/>
    <dbReference type="eggNOG" id="ENOG502Z7YA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007856_0_0_3"/>
    <dbReference type="OrthoDB" id="22544at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1156" mass="136883" checksum="BF7361E4150439AF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W3</accession>
    <name>K9Z5W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2453"/>
    <dbReference type="EnsemblBacteria" id="AFZ54534">
        <property type="protein sequence ID" value="AFZ54534"/>
        <property type="gene ID" value="Cyan10605_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2453"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2598"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_3"/>
    <dbReference type="OMA" id="KHKRTFT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="859" mass="99070" checksum="5E85BCF38FCA903F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z617</accession>
    <name>K9Z617_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219565.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1735"/>
    <dbReference type="EnsemblBacteria" id="AFZ53838">
        <property type="protein sequence ID" value="AFZ53838"/>
        <property type="gene ID" value="Cyan10605_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1735"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1842"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055407_1_0_3"/>
    <dbReference type="OMA" id="YIDGNGY"/>
    <dbReference type="OrthoDB" id="1349509at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022222">
        <property type="entry name" value="DUF3747"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12565">
        <property type="entry name" value="DUF3747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938681" evidence="2">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="32932" checksum="46DBADA70F7E5F6B" modified="2013-03-06" version="1" precursor="true">MFKSLVSRKLSIIALTALASFLPINSAKSVTFQETEVPQEEFIAVAQPYGEDKYNLIVIEQIPGKNQCWNETGANPVNVDLLLLNFDFSGHCRRSTDANGYSIRYDSQDYGLEYILSLVEKDGNLLLMGLNRRSPGQPPVVIGSAKGISESPMKIILNPGWRFTKRTYEGKILGHVYFSYNSASAPQDVVPNMLEEQNQNSDQNNIESILEPNTIESTTEPISEEEILQQGTIQEIVAPEAEPRKEIDKSGKYHRIEDNSNNSTKIDRIDGEESSSNRYNLGQTRFQRMRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z681</accession>
    <name>K9Z681_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220404.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2606"/>
    <dbReference type="EnsemblBacteria" id="AFZ54681">
        <property type="protein sequence ID" value="AFZ54681"/>
        <property type="gene ID" value="Cyan10605_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2606"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2768"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_2_3"/>
    <dbReference type="OMA" id="FYRVYHS"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="349" mass="40210" checksum="64C26D95BDADA25D" modified="2013-03-06" version="1">MSLVNSPSLATIKNLVKNLPNTKKSKWLKKSFKTLIRIVEKKELDRLEWKILTGTLKDLERGFRTFSDYKNRRKITVFGSARTPVDSPEYLLAKDFSHAISQLGFMVLTGAGGGIMEAGNEGASSNNSFGLNIKLPFEQTANKFIFNDPKLINFKYFFTRKLFFLKESDAIALFPGGFGTQDEAFETITLCQTGRQPLIPLVLIDKPGGKYWHNWHNYLVENLLARGYIQEDDIKIYQITDNVESACEIITNFYRVYHSSRYIEDLFVIRLNYDLTDAQLQGLNDSFADVLSRGKIERRRPTKSEKDSLNLPQIAFHLQAKKFSRLYQMIQLINTFSCEESPYCLPQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z685</accession>
    <name>K9Z685_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic nucleotide-regulated ABC bacteriocin/lantibiotic exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220377.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2576"/>
    <dbReference type="EnsemblBacteria" id="AFZ54654">
        <property type="protein sequence ID" value="AFZ54654"/>
        <property type="gene ID" value="Cyan10605_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2576"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2737"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_95_0_3"/>
    <dbReference type="OMA" id="GMLNGPV"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030256">
        <property type="term" value="C:type I protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030253">
        <property type="term" value="P:protein secretion by the type I secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010132">
        <property type="entry name" value="ATPase_T1SS_HlyB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01846">
        <property type="entry name" value="type_I_sec_HlyB"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="11">
        <location>
            <begin position="306"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="460"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="773"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="807"/>
            <end position="814"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113520" checksum="E19A50DBB55C38BC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z694</accession>
    <name>K9Z694_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2616"/>
    <dbReference type="EnsemblBacteria" id="AFZ54691">
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        <property type="gene ID" value="Cyan10605_2616"/>
    </dbReference>
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    <dbReference type="OMA" id="TRTEINH"/>
    <dbReference type="OrthoDB" id="1690080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="22913" checksum="13DFFC58C102FBF0" modified="2013-03-06" version="1">MTEQNLSQKPLIRQRGNLNVNQIQVGEYLAEIQYYKVIKVNPKTIKVISDKGIESTIDKDLVWEMYSASQYHIEKYITRTEINHVLANIGQQIFTVNFNKQVKPTDIKNKLLTAIKDEEGKPLSYEDIEKNLQKISKDLNKGEERTLIGYLLEINNEMGRSSAIDLEIERGKNRLRQIDHRTINYLIFKNTKYIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F0</accession>
    <name>K9Z6F0_CYAAP</name>
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        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2688"/>
    <dbReference type="EnsemblBacteria" id="AFZ54761">
        <property type="protein sequence ID" value="AFZ54761"/>
        <property type="gene ID" value="Cyan10605_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2688"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2852"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_3"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="221" mass="24946" checksum="CDCB7F41DF39B4E2" modified="2013-03-06" version="1">MALSNQLMVEGSRLQRHTSEVAQDVLRMGALVEESFRYSHQALFEGDLETVALITNQDIEIDRYYRHIEMRCATILTLQAPVAQDLRILSAFMQLVRDLERIGDYAKDLGQIAIKLALYPSHSCMPELAAMSKHAQVMLAKAMVALSELDSQAGEKIKLLDDTVDNAYDKLYHTLAQQRDIRGVVEPIILLALAIRHIERMADHATNIAQRVSYIVTGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G7</accession>
    <name>K9Z6G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2105</name>
        <name evidence="2" type="ordered locus">Cyan10605_2252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54194">
        <property type="protein sequence ID" value="AFZ54194"/>
        <property type="gene ID" value="Cyan10605_2105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54337">
        <property type="protein sequence ID" value="AFZ54337"/>
        <property type="gene ID" value="Cyan10605_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2105"/>
    <dbReference type="KEGG" id="can:Cyan10605_2252"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10822" checksum="61E557008FFA5E9A" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSQFPKTEIDGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N2</accession>
    <name>K9Z6N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220573.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2784"/>
    <dbReference type="EnsemblBacteria" id="AFZ54851">
        <property type="protein sequence ID" value="AFZ54851"/>
        <property type="gene ID" value="Cyan10605_2784"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2784"/>
    <dbReference type="HOGENOM" id="CLU_1127613_0_0_3"/>
    <dbReference type="OMA" id="FEICINY"/>
    <dbReference type="OrthoDB" id="1698023at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="29018" checksum="660FCCCE72D87F27" modified="2013-03-06" version="1">MSINVNNFFLKKILFNQYLKDKRFYFFLLGLTASIGDLELVISTVAFLCLMVISYQIKSQYWLNYIHKFTKHLTPENKKLFYSIAIASFFSLSSYFSLNIWTEIDNKWLAFGIIIQTIFSGAGLIFLANILIENKSRNLKANNLFEKIIEQLNDSSPLKRLWAVNQVILQWHHQTFTQEEYEQIREYLTILKDLETEPIIISKIDHCLELITPFFPNNRQRIPINNFPLSRKKKLSSVKTFKILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P4</accession>
    <name>K9Z6P4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photosystem I reaction center subunit XII</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PSI-M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psaM</name>
        <name evidence="8" type="ordered locus">Cyan10605_1978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-31</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PsaM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219798.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M/m/z=2-31"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z6P4"/>
    <dbReference type="STRING" id="755178.Cyan10605_1978"/>
    <dbReference type="EnsemblBacteria" id="AFZ54073">
        <property type="protein sequence ID" value="AFZ54073"/>
        <property type="gene ID" value="Cyan10605_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1978"/>
    <dbReference type="eggNOG" id="ENOG5033BSB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215773_0_1_3"/>
    <dbReference type="OrthoDB" id="2097292at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00828">
        <property type="entry name" value="PSI_PsaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010010">
        <property type="entry name" value="PSI_PsaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037279">
        <property type="entry name" value="PSI_PsaM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07465">
        <property type="entry name" value="PsaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81548">
        <property type="entry name" value="SSF81548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03053">
        <property type="entry name" value="PS_I_psaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="31" mass="3408" checksum="0C198A242BFA8AB8" modified="2013-03-06" version="1">MSISETQVFVALVIALIPGILAFRLATELYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S6</accession>
    <name>K9Z6S6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220171.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2364"/>
    <dbReference type="EnsemblBacteria" id="AFZ54447">
        <property type="protein sequence ID" value="AFZ54447"/>
        <property type="gene ID" value="Cyan10605_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2364"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823140_0_0_3"/>
    <dbReference type="OMA" id="WEAWGVE"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="39641" checksum="D9E7276CE1B9C7A8" modified="2013-03-06" version="1">MTQSICPICEGEMNFHFSVPCDYRKPSEKKEYKVFWCSACDYGHIWDRPLWNEIKESYQIDNYYTHQTQNEQKNKKLRQNSLEEKLRIYIAWRFDFGEHLKLKEISSYLRQKKVENTPKEGSVEKLSICEIGCGSGKNLKKFASLDFDIFGVEPDEEARKVALSITDSIFSGTAEELPTIITQRKYDCVLMSHSLEHTLDINKTIRNIKSVLCDYGLLIIEIPNSKCLGFQKLKGEWPWSDIPRHLNFFTPQSLKLLLERYNFYVESTNYVGFCRHFFPTWLDIEKEIHSAFASNNIDEWKTPNYKLRSWILLLQTLLSSNETKYDSVRMIAINNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W0</accession>
    <name>K9Z6W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220020.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54295">
        <property type="protein sequence ID" value="AFZ54295"/>
        <property type="gene ID" value="Cyan10605_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2209"/>
    <dbReference type="eggNOG" id="ENOG5033N8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197650_0_0_3"/>
    <dbReference type="OrthoDB" id="2057347at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="8536" checksum="8F28508578307F43" modified="2013-03-06" version="1">MMYSFRRVTHAVWSYLNQSITPTEEEYSVWKPSRFWYIYKIRILEKCWLQKSFIPAHEIRGQDEYRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z737</accession>
    <name>K9Z737_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_0911</name>
        <name evidence="16" type="ordered locus">Cyan10605_2896</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218772.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0911"/>
    <dbReference type="EnsemblBacteria" id="AFZ53041">
        <property type="protein sequence ID" value="AFZ53041"/>
        <property type="gene ID" value="Cyan10605_0911"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54959">
        <property type="protein sequence ID" value="AFZ54959"/>
        <property type="gene ID" value="Cyan10605_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0911"/>
    <dbReference type="KEGG" id="can:Cyan10605_2896"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3081"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="CGRINEK"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ53041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ54959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="408" mass="46459" checksum="FFA1FEACE057974F" modified="2013-03-06" version="1">MLKVIKIRIYPDSSQKLALAKAFGSCRWLWNHFLNLMNETYKQTGKGLSGYDVKKLIPELKKQEETSWLSETYSQCLQQVCLNLGVAFNNFFEKRAKYPNFKSKHGKQSLQYPSNVSIKGDCLNVPKIGLVYAKIHRPIDGKIKTVTITKNCCNQYYASVLVDDGKDKPKVSSEGKAIGIDLGLNHFAITSDGSKFDNPKILKKHEVNLKRKQQQLSRKQKGSNNRNKARLKVAKVHKKITNCREDFLHKLSRRIVNENQVIVLEDLNVKGMIKNHCLAKAIQQVGWGQFCTMLKYKAEQEGKTYMEVDRFFPSSKTCHVCLKRVDSLPLDIRHWECPKCKTKHDRDINAAINIRDEGLRILKTGLTRSGNKFRTQPLTSGTGDKAYCPDVRRGRGGRKKSTTPLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B4</accession>
    <name>K9Z7B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220189.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54465">
        <property type="protein sequence ID" value="AFZ54465"/>
        <property type="gene ID" value="Cyan10605_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2382"/>
    <dbReference type="eggNOG" id="COG3930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050360_0_0_3"/>
    <dbReference type="OMA" id="FIMVYNY"/>
    <dbReference type="OrthoDB" id="859435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="DUF1704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="entry name" value="PTHR31817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="370" mass="41869" checksum="C3880613B11A0DE3" modified="2013-03-06" version="1">MTDLKTEKEQERICSVANLLKQANKPIRILGAIAWNPQIKADFFAHQAQKLPEVEYSSFDDSPIIEIIREARKHIFPISSRVDMWLETQANAIEVGARMLANVGKPSFFTFCRQAYGEPTTRLRYDDQTPLQLAESVRDRVARLNYLKIDIDSPKIYSSEDISHKIETAINPHFGEDAPQITIVDELSANALATSKQIRIRRDARFTEQDGIQLINHEAFIHVLTSINGKKQTKLPILGEGHVGTTATQEGLAVFAEVISHSMELNRFQRLADRVFAIQMAIEGADFLQVYHYFLERTQGNEDQSFESARRVFRGDIITGGAPFTKDVVYLFGLLRVGGAINAIGRYSHYYSSSQVMLFSRRKVSIAPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y6</accession>
    <name>K9Z7Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2426"/>
    <dbReference type="EnsemblBacteria" id="AFZ54508">
        <property type="protein sequence ID" value="AFZ54508"/>
        <property type="gene ID" value="Cyan10605_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2426"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2570"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958640_0_0_3"/>
    <dbReference type="OMA" id="AYMGYKL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="31798" checksum="4AF60790C7ACE96E" modified="2013-03-06" version="1">MAQGFNDVNSRLDDISGQLVYLYLLVRDSREKQENLGKAISNIHKAMLIKEITTLQAELEVLRLFPDESPRLALKTATNTRLFLSSQAMQSTPELEAELLLNSDVSIQGWAVATVTEAHLLLQMGQHQEAKGMLREEVEKFKTVAHNWSNSLIKEGNSSLSTAYRFSASPFAEYITPERVTRIKDISPSDLSLDRDQLRRKKNEANVEFEMSYAQERYPKSWIQKQIAIAEYLDSLSELLARLESLEAFADLCESRNLKSSKEILPDENTPSELYLLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z9</accession>
    <name>K9Z7Z9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ordered locus">Cyan10605_2610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220408.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2610"/>
    <dbReference type="EnsemblBacteria" id="AFZ54685">
        <property type="protein sequence ID" value="AFZ54685"/>
        <property type="gene ID" value="Cyan10605_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2610"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2773"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_3"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="6"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ54685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="38488" checksum="861CB34ED70CC69A" modified="2013-03-06" version="1">MTNKYSITLLPGDGIGPEIMAVTVDVLKVIAQQCDLEFSFQEALIGGAAIDATDTPLPTETIEKCRQSDAVLLAAIGGYKWDNLPREKRPETGLLGIRAALGLFANLRPATILPQLIDASSLKKEVVEGVDIMVVRELTGGIYFGQPKGIFTSETGEKRGINTMAYTVSEIDRIAKVAFETAQKRKGKLCSVDKANVLDVSQLWRDRLNAMASQYPDVELTHMYVDNAAMQLVRNPKQFDTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGSDRPGLFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYGLNEPLAADKIEQAVLKVLDLGYRTGDIMSEGCQAVGCQGMGEALLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z803</accession>
    <name>K9Z803_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric oxide reductase, NorZ apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220992.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3228"/>
    <dbReference type="EnsemblBacteria" id="AFZ55274">
        <property type="protein sequence ID" value="AFZ55274"/>
        <property type="gene ID" value="Cyan10605_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3228"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3442"/>
    <dbReference type="eggNOG" id="COG3256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021582_0_0_3"/>
    <dbReference type="OMA" id="VTRTWHT"/>
    <dbReference type="OrthoDB" id="133514at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="769" mass="85592" checksum="075DCAA42F153B9E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z834</accession>
    <name>K9Z834_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)H-quinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="7">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H dehydrogenase I, chain 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NDH-1, chain 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ndhD</name>
        <name evidence="9" type="ordered locus">Cyan10605_2651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220448.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2651"/>
    <dbReference type="EnsemblBacteria" id="AFZ54725">
        <property type="protein sequence ID" value="AFZ54725"/>
        <property type="gene ID" value="Cyan10605_2651"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2651"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2816"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_0_3"/>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00491">
        <property type="entry name" value="NDH1_NuoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022997">
        <property type="entry name" value="NADH_Q_OxRdtase_chain4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="3 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="134"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="58025" checksum="34F5AEFEB68CB0EE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z856</accession>
    <name>K9Z856_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221047.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3283"/>
    <dbReference type="EnsemblBacteria" id="AFZ55329">
        <property type="protein sequence ID" value="AFZ55329"/>
        <property type="gene ID" value="Cyan10605_3283"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3283"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3498"/>
    <dbReference type="eggNOG" id="ENOG5032ZJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191597_0_0_3"/>
    <dbReference type="OMA" id="SWFFEDE"/>
    <dbReference type="OrthoDB" id="1976326at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021291">
        <property type="entry name" value="Tsr0524-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11061">
        <property type="entry name" value="DUF2862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7378" checksum="858B1FFD438AC34C" modified="2013-03-06" version="1">MEVGQKVKICRLREKVSPEILKKAQEGQPAVIKSFKMTDGSGIGVFVEFADSTTGWFFEDEVQVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z885</accession>
    <name>K9Z885_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220664.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2876"/>
    <dbReference type="EnsemblBacteria" id="AFZ54942">
        <property type="protein sequence ID" value="AFZ54942"/>
        <property type="gene ID" value="Cyan10605_2876"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2876"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3057"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_5_3"/>
    <dbReference type="OMA" id="LRCSHEA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="598" mass="67067" checksum="967764B0FCF90383" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z887</accession>
    <name>K9Z887_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabinoheptulosonate-7-phosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220316.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2512"/>
    <dbReference type="EnsemblBacteria" id="AFZ54593">
        <property type="protein sequence ID" value="AFZ54593"/>
        <property type="gene ID" value="Cyan10605_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2512"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2663"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_3"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="352" mass="37930" checksum="D2D591BB4F8E5DEA" modified="2013-03-06" version="1">MIVVMKVGTPEPEITRVSDELATWGLTPEKIVGQHKVVIGLVGETASLNPEQIQEISPWIESVLRVEQPFKRASLDYRHGQPSDVVVPTPNGDVVFGLNHPVVVVAGPCSVENEEMIVETAKRVKAAGAKFLRGGAYKPRTSPYAFQGHGESALELLAAAREATGLGIITEVMDTADLDKIAEVADVLQVGARNMQNFSLLKKVGAQSKPVLLKRGMSATISEWLMAAEYILAGGNSNVILCERGIRTFDREYARNVLDLSVIPVLRSLTHLPIMIDPSHGTGKAEYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQSLTPDRFAQVMQELSVIGKTLNRWESPEAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F4</accession>
    <name>K9Z8F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55434">
        <property type="protein sequence ID" value="AFZ55434"/>
        <property type="gene ID" value="Cyan10605_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3392"/>
    <dbReference type="HOGENOM" id="CLU_181368_0_0_3"/>
    <dbReference type="OMA" id="LLCIRIP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8213" checksum="E95A3EAF3EA9FA0E" modified="2013-03-06" version="1">MTLLFITTIASIFIYQRTNQDIHLILGIFTASVFIIWGLAIAHWSIHMLALLALLCIRIPVFTPKAVKIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G6</accession>
    <name>K9Z8G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221204.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3446"/>
    <dbReference type="EnsemblBacteria" id="AFZ55486">
        <property type="protein sequence ID" value="AFZ55486"/>
        <property type="gene ID" value="Cyan10605_3446"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3446"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3671"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_37_1_3"/>
    <dbReference type="OMA" id="KHRYITH"/>
    <dbReference type="OrthoDB" id="846433at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="300" mass="34194" checksum="FFE6CC9E546963AF" modified="2013-03-06" version="1">MLRRQLYSLNGLQSFEAVARHLSFQKAAEELDVTSTAVSHQIKKLEKELGLLLFRRRPRPLTLTPAGELLFPRVQKSLDVLDNAILELRQINNPTELTVSVLNVFASKWLVPRLNDFQRRHPDIDVRLQTSNTVVDLQARTVDIAIRYGQGNYSGLEVHHLIQDQFTPVCSPKLFAHKQNSITPKEISQHTLIHFDWLNYGSEAPSWKNWLAKAELSEINADKGLKFDDENLAIQAAIAGQGIALCSSIHVQDDVKMGFLIQPFDITLPGFIYSVVYLKNHPKKAFILQFVSWLEEQTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q8</accession>
    <name>K9Z8Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220699.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2918"/>
    <dbReference type="EnsemblBacteria" id="AFZ54980">
        <property type="protein sequence ID" value="AFZ54980"/>
        <property type="gene ID" value="Cyan10605_2918"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2918"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3105"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_1_1_3"/>
    <dbReference type="OMA" id="WRTLTAY"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="39309" checksum="22CF225822795CBB" modified="2013-03-06" version="1">MNFGQSLGFLAFLISLYILWQIRHLLLLVFSAIIFAVALNRLVKKLENIGWNRYQSVYLTVLSLIAIIFILVLLIFPPFIDQFQLLINALPKVPIKINELIENMAGDNYQIFETFLNNINKIINDNNLLPAQVINNFIALFSNFLNVTFQVIFVFVLTVVFLLNPLKYRRYLLKVFPAFYRYRIDEILNKTEIAIVNWLGGILINCIFIGVLSGVGLFFLQVKLVLVHALLAGLLNFIPNIGPTLSVVFPITIAVVDSPWQIIPIIVWYFIIQNIESYWLTPKVMADKVSLLPAVTLFAQIFFATVFGLLGLLLALPLTVVVKTWMEEILFKDILDNWQLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T8</accession>
    <name>K9Z8T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3541"/>
    <dbReference type="EnsemblBacteria" id="AFZ55574">
        <property type="protein sequence ID" value="AFZ55574"/>
        <property type="gene ID" value="Cyan10605_3541"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3541"/>
    <dbReference type="HOGENOM" id="CLU_2421994_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="11231" checksum="1D91D38BC54768DF" modified="2013-03-06" version="1">MRIGQGTFVKRECCFQKENTMPSVLFYQGDRPIYEDEDLEYLEHLEYLKYERENCKTDYWFTFERFPIAWWNTEATSYCLPVEIEPEYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W5</accession>
    <name>K9Z8W5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_2980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220759.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2980"/>
    <dbReference type="EnsemblBacteria" id="AFZ55040">
        <property type="protein sequence ID" value="AFZ55040"/>
        <property type="gene ID" value="Cyan10605_2980"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2980"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3174"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244543_0_0_3"/>
    <dbReference type="OMA" id="VSRCHIH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="164"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="795"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="863"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1410"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="829"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1533"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1154"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="7">
        <location>
            <position position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ55040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1594" mass="182967" checksum="E7231E893AEE1DDB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W7</accession>
    <name>K9Z8W7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ordered locus">Cyan10605_2736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220531.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2736"/>
    <dbReference type="EnsemblBacteria" id="AFZ54808">
        <property type="protein sequence ID" value="AFZ54808"/>
        <property type="gene ID" value="Cyan10605_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2736"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2902"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_0_3"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="316" mass="34718" checksum="D187FF4FD47E7696" modified="2013-03-06" version="1" precursor="true">MIKFSVVKWEKLWWTISAILCLGSIAAMVISYSSIGSVIRPSLDFVGGTRLQIELDCTVPNNCDRALTANEVREVLEAENLGNSSIQIVGQEKQGISIRTKTLDVEERTQLQNALQDNVGVFKAESTQIDTVGPTIGKELFVSGILALLVSFVGTVIYLSFRFQTDYAIFAIVALFHDILITSGVFAILGLVMGLEVDTLFLVALLTIIGYSVNDTVVIYDRIREISKTSNADSMNEIIDIAVNQTLTRSINTSVTTLLPLVAIFLFGGETLKYFALALIIGIFAGSYSSIFVASTLLGWWRKKTNWENPVIVENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z902</accession>
    <name>K9Z902_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannitol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.255</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.255" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3131"/>
    <dbReference type="EnsemblBacteria" id="AFZ55182">
        <property type="protein sequence ID" value="AFZ55182"/>
        <property type="gene ID" value="Cyan10605_3131"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3131"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3337"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_3"/>
    <dbReference type="OMA" id="YRFSIDM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046029">
        <property type="term" value="F:mannitol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="36466" checksum="3764D52C676B5C14" modified="2013-03-06" version="1">MTIVNAYAAHETGGLLKPFQYQLPPIGAYEVDIQVQHCGICHSDLSLLENAWGVTQYPFVPGHEIVGTVLAVGQDVVHLKEGDRVGLGWHSAYCLHCDQCLTGNHNMCYSAQATIVGRHGGFADIVRAKVPSVVKLPDSVDMRTAGPLLCGGITVFNPLIQFNILPTAKVGVIGIGGLGHIAVQILQAWGCEVTAFTSSESKIEEALKMGANKTLNSRDSEELKSAENSFDLILSTVNVELDWSTYLSLLKPKGRLHLLGVVLEPLNLSVSSLLSRQKSVSASPVGSPNAIAQMLEFCQRHNIKPITQHFPLKEVNEAMEHLRAGKARYRVVLDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z920</accession>
    <name>K9Z920_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="10" type="ordered locus">Cyan10605_2811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220600.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2811"/>
    <dbReference type="EnsemblBacteria" id="AFZ54878">
        <property type="protein sequence ID" value="AFZ54878"/>
        <property type="gene ID" value="Cyan10605_2811"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2811"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2988"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_3"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="146"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="449" mass="49882" checksum="6148EF58004A6005" modified="2013-03-06" version="1">MSKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILEEELMPSNRSQPSHSAVKSNPRPSKKTSSTRKPLSLSKLPKPKEIKELLDQYVIGQDEAKKVLSVAVYNHYKRLTVAESEQKTGKSKEETIELQKSNILLIGPTGSGKTLLAQTLANILDVPFAIADATTLTEAGYVGEDVENILLRLLQVSNLDLDEAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQGGRKHPYQDCITIDTSNILFICGGAFVGLDKIVEQDQEKKILGFQIPAENTTKEERVSKAARQLQPDDLVRFGLIPEFAGRLPVVAVLDPLNEEALMEILTRPRNALVKQYQKLVGMDNVILEFEPEAIRAIAQEAYRRKTGARALRGIVEEIMLDVMYEIPSRQDVQHCVITKEMVEKRSTAELILHPSSLPEPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z930</accession>
    <name>K9Z930_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2821"/>
    <dbReference type="EnsemblBacteria" id="AFZ54888">
        <property type="protein sequence ID" value="AFZ54888"/>
        <property type="gene ID" value="Cyan10605_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2821"/>
    <dbReference type="eggNOG" id="ENOG50331KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186816_0_0_3"/>
    <dbReference type="OMA" id="NMGRDRW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8657" checksum="61E60AEDE03C3151" modified="2013-03-06" version="1">MDYLQSLFNPKYCQSALKVALFVGTMLFTINHGSALIQGEMTQQRWISGMLTYLIPYSVNIHGRWSSSRLKSPESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z936</accession>
    <name>K9Z936_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase IS891/IS1136/IS1341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_3063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220839.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3063"/>
    <dbReference type="EnsemblBacteria" id="AFZ55120">
        <property type="protein sequence ID" value="AFZ55120"/>
        <property type="gene ID" value="Cyan10605_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3063"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3265"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="SERIHTC"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="199"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="407" mass="47458" checksum="87F089C6FC0AE2D6" modified="2013-03-06" version="1">MLNLSYEYKLKPSKFQVEQIEHTLDVCRSIWNFALLERIDWVRSRKSPVNACSIQQEYIISPETKYPNYNQQAKSLTLARKQNERIASVNAQVEQQVLRTLERAFADREKKKLGFPRFKNRNRMRSFVFPQMLNNCIQGNRIKLPQLGWVKFRQSRPIPDGFLVKQARIVRKATGYFVILSLQSDVDIPRPIPHGHPKGLDLGFILAVVTSDNESIPRPRFLNKYARELKRLQRRLKNKQKGSCGWRELQKRISRLHFKIACHRKDYHFKLSHHLVQDTGMIFVEDLDFKSWQRSFLSKSSADFAFGQFVNILEWVCFRTDTYFEKVDYRYTSQECPECGVMTGRKYLQERVHHCPECGFTTGRDHASALVVLKRGLDLVAVGQPVQEKASGDGRSGGEFIRLATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z941</accession>
    <name>K9Z941_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220844.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3068"/>
    <dbReference type="EnsemblBacteria" id="AFZ55125">
        <property type="protein sequence ID" value="AFZ55125"/>
        <property type="gene ID" value="Cyan10605_3068"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3068"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_5_2_3"/>
    <dbReference type="OMA" id="KVPTIAC"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="6978" checksum="0FEAE670B239C345" modified="2013-03-06" version="1">MANITLNVPSIACEVCAKTITKAIQNVDNIAEINVDVKTKMVNVTTQKAEEIIKQAILDAGHDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z942</accession>
    <name>K9Z942_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220955.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3188"/>
    <dbReference type="EnsemblBacteria" id="AFZ55237">
        <property type="protein sequence ID" value="AFZ55237"/>
        <property type="gene ID" value="Cyan10605_3188"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3188"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3398"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_3"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="276" mass="29894" checksum="1C0891E6FE3EB5E9" modified="2013-03-06" version="1">MSNFKPKKKNQPSKPKSSVSPASENLNTFENELSSDLIYGSYPVLAALENGQQLNRLYLNSRMLHDSRFESLIPQAKANGTVIDVVDNKRLDQLTNRANHQGIVATVAPYEYVDLSELIDKAKSETDNPVIIIADGINDPHNLGAIIRTAEAFSMQGLIIPQRRAVGVTSTVMKVAAGALAYFPVARVVNLNNAIASLQEAGFWIYGTMMEGNSLHNTKFEGAIGLVIGSEEKGLSPSTAKACDFLVSIPMTGKTPSLNASVASAICLYEIRRQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z949</accession>
    <name>K9Z949_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220635.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2846"/>
    <dbReference type="EnsemblBacteria" id="AFZ54913">
        <property type="protein sequence ID" value="AFZ54913"/>
        <property type="gene ID" value="Cyan10605_2846"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2846"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3025"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051006_0_0_3"/>
    <dbReference type="OMA" id="WLTNPVY"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="454" mass="53357" checksum="28AEF13657AE950F" modified="2013-03-06" version="1">MRIVAYSYIEPLIDSIPDPQIWGWEIEEIYQDIDTREKLNQLFIDSQDNAPDYLLINSLHELGNSLTEVENNIFKLESLNIEIISLQQDYHSKNFHNVTSIQQKKELLKIWQEIESLIKHRKLKKAHAKNRLNILPPPGKPPYGYLRGKDGYIVNRATAPIIRAFFDRFLLYGSLQDAVNYLAEKYNKKISVSTAKYWLNNPIYRGDLNYKNKQIIPDTHTAIITREESAQIERIFQSHRRVKSKSASSQHCLAGLIQCQWCKSNFRVNTVTKRNKSANYLYLTPVECQKEIPCKSINYDFVLQKVIENICNSFKEIKNQEQMPNIEQIKNYLLTEINQKKRVITQIEKLLEEKILDEETAKIRTYKIKQDIGVLKQQIAKLPPNSLNTIANTLSLPQFWYDLSSSEKRFYLREFVKIIEIIPQNNYPQKKDIQLNFVFANAQLNNSWQNREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H6</accession>
    <name>K9Z9H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urea-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220943.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3174"/>
    <dbReference type="EnsemblBacteria" id="AFZ55225">
        <property type="protein sequence ID" value="AFZ55225"/>
        <property type="gene ID" value="Cyan10605_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3174"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3383"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_1_3"/>
    <dbReference type="OMA" id="AQPWSPY"/>
    <dbReference type="OrthoDB" id="538961at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938651" evidence="2">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="436" mass="47357" checksum="29D2300E9AC0467D" modified="2013-03-06" version="1" precursor="true">MSRLGRRKFLLYGSATLGTSLLLKACADAPPPADDTATDTTTETPSGGEGDTIKVGILHSLSGTMAISETTVVEAEQLAIEEINASGGVLGKQIEAIVEDGASDWPTFAEKATKLIDQDGVVTVFGCWTSASRKAVLPVFESKNHMLWYPVQYEGQECSKNIFYTGAAPNQQIEPAVDWLLENKGKEFFLVGSDYVFPRTANTIIKAQLEAKGGTTVGEDYLPLGNTEVTPIITKIKAALPNGGVIFNSLNGDSNVAFFKQIQAAGLTPDKYPVMSVSIAEEEVRQIGVEYLKGHYAAWNYFQTVESPENEKFVEAFRAKYGQDRVTNDPMEAAYIMVYLWKQAVEAAGTTDLEPVRSAAVGQSLQAPEGLVTMQPNHHISKTVRIGQVRDDGLFDIVFATDAPVDPIPWNQYVAETKGFACDWTDPAKGGKYKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J0</accession>
    <name>K9Z9J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221110.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3350"/>
    <dbReference type="EnsemblBacteria" id="AFZ55392">
        <property type="protein sequence ID" value="AFZ55392"/>
        <property type="gene ID" value="Cyan10605_3350"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3350"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3568"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_3"/>
    <dbReference type="OMA" id="VDWGEDI"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17214" checksum="BE14F7A3702BECA6" modified="2013-03-06" version="1">MWRNWQFISGVLKIIFRHPVMGVTLVPVLPDGRVVLVYRRDCQQWSLPGGMIDWGENVPNTARRELKEETGLDLVNISRLVGVYSSPDRDPRLHSICVLIEVEATGELSVKDTWEISEVKAFPPQEIPIGNLAHDHDRQIQDYLEGKNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K8</accession>
    <name>K9Z9K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220787.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3008"/>
    <dbReference type="EnsemblBacteria" id="AFZ55068">
        <property type="protein sequence ID" value="AFZ55068"/>
        <property type="gene ID" value="Cyan10605_3008"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3008"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3205"/>
    <dbReference type="eggNOG" id="ENOG502ZX30">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145470_0_0_3"/>
    <dbReference type="OMA" id="TEVKQRG"/>
    <dbReference type="OrthoDB" id="1646374at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009666">
        <property type="entry name" value="Uncharacterised_Ycf35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39638">
        <property type="entry name" value="PTHR39638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06868">
        <property type="entry name" value="DUF1257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="12960" checksum="603BEA90B22EBA34" modified="2013-03-06" version="1">MSHFSTLRTKITDAEILTNSLKDLGINVKTDADVRGYNSQRIRADIVAVLDGEYDLGWSRNADGSFDLIADLWGVAKKHNQTELINSINQKYAVNKTLSEVKQRGLQNANVKLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9S1</accession>
    <name>K9Z9S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220842.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3066"/>
    <dbReference type="EnsemblBacteria" id="AFZ55123">
        <property type="protein sequence ID" value="AFZ55123"/>
        <property type="gene ID" value="Cyan10605_3066"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3066"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038688_0_0_3"/>
    <dbReference type="OMA" id="PNRRWYP"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="415" mass="47919" checksum="2FD6AA3746BF3A6D" modified="2013-03-06" version="1">MNKDDENIKISDEFLQLCHSQLNLLFTQFFAQESVIYLTDSQAEEPKLIPILVYPNSSSHHFPSLPPLQENPWEDSFSDALDEKKNSEPLINYYPNSHAPHQLILPLIYQNIVLGLLATTRKNSPWQPTEILQIKEITNTIAIARILEQKQQITVEKLSQLQKFRQLESDHLDDFLHQLRNPLTAIRTFAKLLLKRLFVDDPNYSTSQSIYRESDRIKELIADFSEQWQGKNEEEIFTLDTLHTSFFLTENIENLEVVNIINVIKPMLENIRIIAEEKNIQVLEKINIDTEFILTNKKALREIINNLLDNAVKYTPNNGKVRIEIEQNKGDKIIVKIADTGYGIPLEDQTHIFERHYRGSQINGNISGTGLGLAIVKELADKINIKIKLISPFQWLENQVDNGTEFILEIPINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA27</accession>
    <name>K9ZA27_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ordered locus">Cyan10605_3152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220921.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3152"/>
    <dbReference type="EnsemblBacteria" id="AFZ55203">
        <property type="protein sequence ID" value="AFZ55203"/>
        <property type="gene ID" value="Cyan10605_3152"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3152"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3359"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_3"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="53"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="33420" checksum="BBB4098646F2B042" modified="2013-03-06" version="1">MVNTETITPKKPNWLRVKAPQIQRVGTVKDILRDLELNTVCEEASCPNIGECFNAGTATFLIMGPACTRACPYCDIDFDKTPRGLDETEPLRLAEAVKRLKLNHVVITSVNRDDLPDGGASQFVACIEETRKISPNTTIEVLIPDLCGNWDALATILKAQPEVLNHNTETVPRLYRKVRPQGEYARSLLLLEKTRELSPKTYTKSGIMVGLGETDEEVKQVMEDLRKIDCDIITIGQYLQPSSNHLAVKEFITPEQFKAWQEYGESIGFLQVVSTPLTRSSYHAGEVRRLMEKYPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAF3</accession>
    <name>K9ZAF3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circadian clock protein KaiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kaiB</name>
        <name evidence="4" type="ordered locus">Cyan10605_3318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. The KaiABC complex also interacts with SasA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KaiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221081.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3318"/>
    <dbReference type="EnsemblBacteria" id="AFZ55363">
        <property type="protein sequence ID" value="AFZ55363"/>
        <property type="gene ID" value="Cyan10605_3318"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3318"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3532"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144073_0_0_3"/>
    <dbReference type="OMA" id="NEFKGVY"/>
    <dbReference type="OrthoDB" id="1999883at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042326">
        <property type="term" value="P:negative regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02978">
        <property type="entry name" value="KaiB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01835">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013474">
        <property type="entry name" value="Circ_KaiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039022">
        <property type="entry name" value="KaiB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011649">
        <property type="entry name" value="KaiB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41709">
        <property type="entry name" value="PTHR41709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07689">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01248">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02654">
        <property type="entry name" value="circ_KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11445" checksum="1DEEF5AC37CA9AE0" modified="2013-03-06" version="1">MSPIKKTYVLKLYVAGNTPNSVRALKTLKNILEEEFKGVYALKVIDVLKNPQLAEEDKILATPTLSKVLPPPVRKIIGDLSDREKVLIGLDLLYEEIRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAJ5</accession>
    <name>K9ZAJ5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221136.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3376"/>
    <dbReference type="EnsemblBacteria" id="AFZ55418">
        <property type="protein sequence ID" value="AFZ55418"/>
        <property type="gene ID" value="Cyan10605_3376"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3376"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3594"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_3"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="31286" checksum="B80D981941FD3D38" modified="2013-03-06" version="1">MTKFASHANQKILTALERLIDIVAKLRSPLGGCPWDLAQTQESLIPYIIEEAYEAVDAIYSQNQAEIAEELGDLLLQVVLQAQIAQENEYFTLEDIAEGISEKLIRRHPHVFGDVEVASEEEVHHNWEKIKQEEKQKTHALLSEKLKTYVRSLPPLMATLKISKQAAKAGFEWENVEGVWDKFQEELKEFQEAIIKGDLQHAETELGDLLFTVVNLGRWYGIDPTVALQGTNNRFIQRLSLMEQKCDRPLQEYSLTELEVLWQSAKKQLSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAN6</accession>
    <name>K9ZAN6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE associated Golgi family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221176.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3416"/>
    <dbReference type="EnsemblBacteria" id="AFZ55458">
        <property type="protein sequence ID" value="AFZ55458"/>
        <property type="gene ID" value="Cyan10605_3416"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3416"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3640"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_4_2_3"/>
    <dbReference type="OMA" id="FMYGFRI"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23166" checksum="185C1B5B9AB2E9C7" modified="2013-03-06" version="1">MEFLSLEQIKELAHLYGYWAVFAGIAIENTGIPIPGETITIVGGFLAGSGELNYWLVLLTAIAGAVTGDNCGYWIGRIGGWQFLLKLARFFRLPETEVEKAKSKFVDNAAKAVFFGRFITLLRIFAGPIAGIVEMPYPKFLFYNFMGATVWGAIIVTLAYFVGRIVPLAQLVSYLAQFGIVALLAVIAWVVIPLWFKSYNAQKRVKGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAP2</accession>
    <name>K9ZAP2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221181.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3423"/>
    <dbReference type="EnsemblBacteria" id="AFZ55463">
        <property type="protein sequence ID" value="AFZ55463"/>
        <property type="gene ID" value="Cyan10605_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3423"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3648"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047712_0_0_3"/>
    <dbReference type="OMA" id="YKFYWFL"/>
    <dbReference type="OrthoDB" id="1105453at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="253"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="45286" checksum="D844C34058A43847" modified="2013-03-06" version="1">MNHNYHNLPLSNHLNILAFSQLFRSTTNSYKYLFFYSILDILSQRLFDDSESISFQELMIEMLANAWYPHTFFRLSFGKQDRIANKLDSLDLRVNTTVLKFNSSDKIALKEIISQNNLTAIITDFKKNVPFRLLRPFLLEKLRDFDVNYEVVKKTPEIASQYFSILKPLYRFNANTYQDSTAILLHPDWVEYFKQNFIIIKGWVTWEWLQYMQKNNQNVPNLVNKLFAPEKRNSLTNQANYWRFILEKQPIKCIYSGQILNKNSISIDHYLPWSFVAHDHLWNLIPTMNNINSSKSNNIPSSQYLAKFIQLQHQGLTISHQYLPRKDWLKYTENYLLDLKISHTEDLLNFELLTNIYKRHFQPLISIAKIYGFNDNWTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAP8</accession>
    <name>K9ZAP8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221186.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3428"/>
    <dbReference type="EnsemblBacteria" id="AFZ55468">
        <property type="protein sequence ID" value="AFZ55468"/>
        <property type="gene ID" value="Cyan10605_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3428"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632207_0_0_3"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="9006" checksum="CC20514BBC45EDB6" modified="2013-03-06" version="1">MTFSNTILSESIYLDYHATTPVDRRVAEKVYDYMVNNFGNSSSIDHIFDNQATKKIKQSLVNFIFHLNFLLRKNNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZG6</accession>
    <name>K9YZG6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUCC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218036.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0147"/>
    <dbReference type="EnsemblBacteria" id="AFZ52304">
        <property type="protein sequence ID" value="AFZ52304"/>
        <property type="gene ID" value="Cyan10605_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0147"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.153"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030017_1_0_3"/>
    <dbReference type="OMA" id="RMGLWGA"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06176">
        <property type="entry name" value="MFS_BCD_PucC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026036">
        <property type="entry name" value="PucC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004896">
        <property type="entry name" value="PucC-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23538">
        <property type="entry name" value="PTHR23538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03209">
        <property type="entry name" value="PUCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016565">
        <property type="entry name" value="PucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="481" mass="51660" checksum="4359E5A48ED35032" modified="2013-03-06" version="1">MTSNNYQSISLSDTTIPKVNTLTMFRLGLFNLGIGLISVLTLAVLNRVMIAELGIPASIAAGVLAISQLVSPTRIWLGQLSDGKKLFGFHRTGYIRLGVIISGIAIFFAIQLVWLLGSNIIINNGWQWNNVTIFVSILLAIVFVVQGIATGACSTPFTALLVDISDEDNRSKIVATIWSMLMVGIVIGGISGKILLNNLSGVEGKGIPLATLQAPINGIFLVVPIIVVILTLVATWGVEKKYSRFRQRSSFQDREEGVSFKKALKILTSSRQTGIFFSFLVMITLSLFMQEAVLEPYGAEVFNMPIGDTTLLNSFWGMGILLGYGTTGFFVVPRLGKNNTTRLGCILVALSFGLIIFSGLTQTPSVLKGAMVLFGIAAGITTIGAISLMLDLTVAETAGTFVGAWGLAQSLSRGIAIAVGGWILDLGRFLFNNPWLAYSLVFVCEALCIIGAIALLNRVNVQEFQATTRKATAMVMEGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZJ2</accession>
    <name>K9YZJ2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218066.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0177"/>
    <dbReference type="EnsemblBacteria" id="AFZ52334">
        <property type="protein sequence ID" value="AFZ52334"/>
        <property type="gene ID" value="Cyan10605_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0177"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.186"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_0_3"/>
    <dbReference type="OMA" id="FFFINGH"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="27354" checksum="000DE7B7AD988790" modified="2013-03-06" version="1">MQLHLLTWQEVEKYLTHSNGIIIPIGSTEQHGPTGLIGTDAICAEKIAQGVGENTGAIVAPTINVGMALHHTAFPGTISLRPTTLILYIQDYLTSLFKAGFKKFFFINGHGGNIATVKASFSQFYDHLDSMNFANSEQVKCKIANWFMGREVYQLAKKLYGDEEGSHATPSEVALTQFVYPDTIKSAPLDKSVATGHPIYGAKNFRECYPDGRMGSNPALATPEHGKQFYELAVKELTASYQDFISINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZT9</accession>
    <name>K9YZT9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polymorphic membrane protein Chlamydia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218198.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0318"/>
    <dbReference type="EnsemblBacteria" id="AFZ52466">
        <property type="protein sequence ID" value="AFZ52466"/>
        <property type="gene ID" value="Cyan10605_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0318"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476278_0_0_3"/>
    <dbReference type="OrthoDB" id="1838643at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="572" mass="60755" checksum="1169B6CFE5F2278B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZZ8</accession>
    <name>K9YZZ8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218262.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0387"/>
    <dbReference type="EnsemblBacteria" id="AFZ52531">
        <property type="protein sequence ID" value="AFZ52531"/>
        <property type="gene ID" value="Cyan10605_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0387"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.409"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849007_0_0_3"/>
    <dbReference type="OMA" id="IAARHYP"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36999" checksum="D3F50090EE84FFC9" modified="2013-03-06" version="1">MFNFRIQADSHISPSQQLIDQIQFAIASGQYPPGHRLPSTRQLAQITNLHRNTISKVYRQLEKKGLVESITGSGIYVKSQGDEGKKKNKHLVGLESSQADIIKRTIDQLLEQGNNLEQIKQLFFEEIEWRLRCSALILVTVPKVDIGAGQLMVLELEQALLVPTQLVPLEELNHILTQTTSATVVTSRYFVPQVLEIVSPESIRVIPIDIYDYKKELTIIRQLSKNTNLGIVSLSGGILRVAEILIHSLRGDEINTITATIHDQRKLNHLIRFSDVIMCDRNCSTLVKKNLQKLQSDLIRIPKIIATNNYISEKSIQLLKKELEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z009</accession>
    <name>K9Z009_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0397"/>
    <dbReference type="EnsemblBacteria" id="AFZ52541">
        <property type="protein sequence ID" value="AFZ52541"/>
        <property type="gene ID" value="Cyan10605_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0397"/>
    <dbReference type="HOGENOM" id="CLU_2786922_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="8014" checksum="900F2311750D2C09" modified="2013-03-06" version="1">MLVNQFFFLSKVILLSTLISFIIKYGLDNWILEINETFLAIFIISFPVITLVIILLVKHQRELSKWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0E7</accession>
    <name>K9Z0E7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="7" type="synonym">rps11</name>
        <name evidence="9" type="ordered locus">Cyan10605_0502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218375.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0502"/>
    <dbReference type="EnsemblBacteria" id="AFZ52644">
        <property type="protein sequence ID" value="AFZ52644"/>
        <property type="gene ID" value="Cyan10605_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0502"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.532"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_3"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="13620" checksum="78917D6D55B362D0" modified="2013-03-06" version="1">MAKPTKRGGPKKQKKNIPSGTAYIKSTFNNTIVTITDTTGNVISWATAGSSGFKGAKKGTPFAAQTAADSAARVAMDNGMKQVEVMVSGPGAGRETAIRALQGAGLEITLIRDITPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N2</accession>
    <name>K9Z0N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52746">
        <property type="protein sequence ID" value="AFZ52746"/>
        <property type="gene ID" value="Cyan10605_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0607"/>
    <dbReference type="eggNOG" id="ENOG5033BPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174108_1_0_3"/>
    <dbReference type="OMA" id="YGGTWKG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="7096" checksum="1F8EB3142F6C7DF4" modified="2013-03-06" version="1">MARTKKLKSCDYCHQLVNLRYRIQYDESNKWYQVCPNCWNVLAKDNPFYRYGGTWKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U9</accession>
    <name>K9Z0U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218094.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0206"/>
    <dbReference type="EnsemblBacteria" id="AFZ52362">
        <property type="protein sequence ID" value="AFZ52362"/>
        <property type="gene ID" value="Cyan10605_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0206"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_4_1_3"/>
    <dbReference type="OMA" id="CIANWIV"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="265" mass="29410" checksum="00DF580970A8E684" modified="2013-03-06" version="1">MANQNHLNLIRNIHEWNKWRLQNPYSIPDLSNADLQGLNLANVNLGDANLKGANLQGCNLTDADLTKANLHQANLKEANIRRANCYKANFTFANLEKAYLSEADLSMAEMESVNCQYTDFTESYLIKANLTNGNFTHSNLQGAVLTEANLLGCRLVSANLREADLGGIIGTHTDFYGADMSGVSLEDWHIDDTTKLDYVICDYCSLSPNKSVKFYQGLTPINLRLELSKSADSSSVKKQSTPAYNASSVRKNYLHQGDSPYLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z193</accession>
    <name>K9Z193_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218067.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0178"/>
    <dbReference type="EnsemblBacteria" id="AFZ52335">
        <property type="protein sequence ID" value="AFZ52335"/>
        <property type="gene ID" value="Cyan10605_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0178"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.187"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_3"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30072" checksum="3A41B91A56257363" modified="2013-03-06" version="1">MKSYLAAAVCMTSTPDVDHNLNQAEELIELAVNQGAKLVGLPENFSFLGEDKDKIAQGEDIAQRSEKFLIRMAQRFQVTILGGGFPTPLPGDKSKVHNTALLIDPNGLELARYEKIHLFDVNVPDGNNYCESNTVMAGKSLPNVCEVNNLGKIGLSICYDVRFPEVYRHLSRQGAEVIFIPAAFTAYTGKDHWEVLIRARAIENTVYVIAPAQTGNHYARRCTHGHSMIVDPWGSILSSTGSQIGVAIAEINPQRLQKVRQQMPCLQHRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B4</accession>
    <name>K9Z1B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_0377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218253.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52522">
        <property type="protein sequence ID" value="AFZ52522"/>
        <property type="gene ID" value="Cyan10605_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0377"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="NEYQDEH"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="13">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="14">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="403" mass="45943" checksum="F62F0A438C4D776E" modified="2013-03-06" version="1">MHRAIKVRIYPNKTQAKKLSQVMGCCRWWYNYALNLCIDTYKATGKALKQVALNKYLPKLKKEEDTAWLGDCYSQCLQSTTLNLTKAFKNFFEGRAKYPRYKSYQGRQSCQYPQNVSIVDGCLKIPQLGLVKAVIHRIFEGEIKTVTVSKTPTGKYYASILFDTKQTFPEVTITGKVCGIDLGIKDFAIVHDGRKTSKYANPRHIKKHEKNLARKQQKLARKKKGSKNREKARKLVAKVHERISNARQDFLHKLSRKIVNNNQVVVIEQLNIKGMVRNHNLAKAISDVGWGTLINFLDYKLKQKGGLLVEIDRWFPSSKTCSHCHYQMSEMPLEIREWTCPSCGSHHDRDENASKNIRAEGIRKIQTDGTAVSASGGSVRPKGGRKSVLRHEPVKDEAHTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F1</accession>
    <name>K9Z1F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218725.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0862"/>
    <dbReference type="EnsemblBacteria" id="AFZ52994">
        <property type="protein sequence ID" value="AFZ52994"/>
        <property type="gene ID" value="Cyan10605_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0862"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.906"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_4_2_3"/>
    <dbReference type="OMA" id="EHLTECI"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13261" checksum="22DB86737392E75D" modified="2013-03-06" version="1">MTTVFPENNPQQHKHSHNNNKQHHHGHIHSEESQRKIINRLSRIEGHVRGIKTMINEGRDCPEVLIQIAAIRGALDRVARLILDEHLSECITRAAEEGGIEEEIAALKSALDRFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G8</accession>
    <name>K9Z1G8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218787.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0926"/>
    <dbReference type="EnsemblBacteria" id="AFZ53056">
        <property type="protein sequence ID" value="AFZ53056"/>
        <property type="gene ID" value="Cyan10605_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0926"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.973"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_11_5_3"/>
    <dbReference type="OMA" id="KGANIMD"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="35857" checksum="D40DD596CB60EACC" modified="2013-03-06" version="1">MEINQFIERYTSGDHNFTGAMLAGIDLTNSDLIGIILREANLQKTNFTFAYLNRADLSRANLVEANFSGTNLNQANLMGANLHRAELHGAILQKADLRGVELTLANLLDANLFEVDLRYANLSNANLKGACLRSVNMRREKRSEPTNLRGVNLDKADLKNSDLRGVDLRNASLVGANLVEVNLRGADLTNADLTQANLKGAFLTEAEFMGAKLIGANLSNAKLERTKLVDADLSMANLESATMPDVKFTRANLLQANLSFARLNRGDLTRANLYGAVMRNASLMEVFFARTNLTSADLTNANLIGADLSSANLTGVNLQGAIMPDGQVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I9</accession>
    <name>K9Z1I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218177.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0297"/>
    <dbReference type="EnsemblBacteria" id="AFZ52445">
        <property type="protein sequence ID" value="AFZ52445"/>
        <property type="gene ID" value="Cyan10605_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0297"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.308"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_3"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="30688" checksum="0BD7798D60B24575" modified="2013-03-06" version="1" precursor="true">MLKLFWSKLIRDKTAIVALTILSFIIIAIIFLPLVYTTPIDMIDFSQSSLPPNWQHPFGTNDLGQDQLARILFGGRVSLTVGITSMIVAISVGTMVGAIAGYYGGVIDNILMRITDICLSLPQLPILLLVIYLFRDPVKSLLGAELGIFSLVVLIIGLLNWMSVARLVRSSFLQIKEREFISAARSLGANSLRIMWQHILPNVINIIIVAATLAVGNGIIVESTLSFLGLGFPPDIPTWGRMLYEAQEYLPTSPHMAIFPGLAIFLTVLSINYLGDKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X2</accession>
    <name>K9Z1X2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218438.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52707">
        <property type="protein sequence ID" value="AFZ52707"/>
        <property type="gene ID" value="Cyan10605_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0566"/>
    <dbReference type="eggNOG" id="ENOG5034718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508223_0_0_3"/>
    <dbReference type="OMA" id="KTEYNIF"/>
    <dbReference type="OrthoDB" id="1874356at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="204" mass="22991" checksum="87470E3DD0074076" modified="2013-03-06" version="1">MKILTAHELTQQGISLADVQKSLTMTYLTKNFRRKSDLPKKFRDKALNLCAEIEGLGKESFVIETSYSYTVWEEEKVANVEVKNLNSVSPVEANINIQSSQISALDNNKSKDNNRVGKSKSSSQENYSKTEYNIFQYSSKGDGFDHLKARKNQTASISLDTSEDLVKYRGVVVNQPPTEVVNTPQNKPSATPKRKPRTYRGVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X3</accession>
    <name>K9Z1X3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218321.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0446"/>
    <dbReference type="EnsemblBacteria" id="AFZ52590">
        <property type="protein sequence ID" value="AFZ52590"/>
        <property type="gene ID" value="Cyan10605_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0446"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570893_0_0_3"/>
    <dbReference type="OMA" id="WSMSEFE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="235"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="53244" checksum="D14B93245ECB5A7E" modified="2013-03-06" version="1">MSRPLFCHWQKDIAPEIENKRKDAIAALGLDLEKTIPVFDEATQTAADSLNVPICCLGILIEEEYKMKSAYGLSHLGLMNDLAISRKIPRQDAFATYVIDSSNYLTINNTLTDSFFSYSLLASQYGIVAYLGVPLITETGECIGCLEIIDTKPRQFIQTEINFLMITARWCLAEYERSIIKNSLHLNFDKKETKNKSQKDFPETECTSSTDELAIKPTPNSEKYIRELSFQLLNQLIQKLSIPLTSIIGMSSVLKQGIYGQLNSKQAEYLQIIHDSGQEMSILVDEIAKLGNVKSEVNLEYVPVDLENLGTQVLQSLESSAQNKEHTLRLSIEPGKKIWNLDREKAKKTLYYLVNTIIEGSRSGGEIHLHISHRGDILKISCRVNHPWLGEGISLEKIGLYEEVLNNKELSSNLIGDEDRLNPENTNLSNLDYDLVCLSFSAYLANLQGGSIYLQGSVESGYRFILSLPISPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X4</accession>
    <name>K9Z1X4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218912.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1057"/>
    <dbReference type="EnsemblBacteria" id="AFZ53181">
        <property type="protein sequence ID" value="AFZ53181"/>
        <property type="gene ID" value="Cyan10605_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1057"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1118"/>
    <dbReference type="eggNOG" id="ENOG50316GF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748753_0_0_3"/>
    <dbReference type="OMA" id="YIECRED"/>
    <dbReference type="OrthoDB" id="1717032at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17276" checksum="331752D0F3D9CC8C" modified="2013-03-06" version="1" precursor="true">MSRTRKSHKKIELELFPFLSVLACTIGSLILLIIVVSTQTLDSNPEVKIIAQAEDGANQQKQPRYIECREDGVVIYPSEEFIPTNQLENSNSAFLQLIRDVREKRDQEYIIAAIRPKGIEVFEKVRSIIEKEEIDIGYEPIEEDWTLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z3</accession>
    <name>K9Z1Z3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218932.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1078"/>
    <dbReference type="EnsemblBacteria" id="AFZ53201">
        <property type="protein sequence ID" value="AFZ53201"/>
        <property type="gene ID" value="Cyan10605_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1078"/>
    <dbReference type="HOGENOM" id="CLU_513753_0_0_3"/>
    <dbReference type="OrthoDB" id="1540668at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029468">
        <property type="entry name" value="O-ag_pol_Wzy"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14296">
        <property type="entry name" value="O-ag_pol_Wzy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="487" mass="56217" checksum="D8582ABF50DCDE7F" modified="2013-03-06" version="1" precursor="true">MNKTIKKICFLIYLSELLLLITFVLLNQKYDVANFRDYCLFSVIFCPLQIFFLLIATRISVLSFPSVYLFITYLFTNSAFILYLFLGSFGLSALRLVNYEYLSMSVPLVAMAFVSFSLGTLTSKTSKQIIKKSMVSKLFQINNYQRKFHEYYLSIICVFIILFCLGFIGFLYLQGKGLAVMIQGGYHEFARIEKNDFSQKFLVASLTWLIPWSTLALLAISSSSTKSIRMSFIWIFISCALLLITGDRGAALPILLIYIQSYSISVSKFNWLRWSLILIFIFLLVPLVQVLRGIPVSQWNFILLQDIILNSDKYFSTYLQAFFEPFSSTIETLMGTLMQINFMEDYRWGIDYLLSILSAIPFNSGMAPSNSQWVKEYIAPNTVAGIGFLAIAESYLNFSWIGIIVVFTFLGNLMGKYWSLLRNKMLTTIDLSMILIVFYSMTIWVRNEFSLVSRTILWSWFLIYISPKILSYFLGKKSIKYPLNDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z217</accession>
    <name>K9Z217_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0493"/>
    <dbReference type="EnsemblBacteria" id="AFZ52635">
        <property type="protein sequence ID" value="AFZ52635"/>
        <property type="gene ID" value="Cyan10605_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0493"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_4_1_3"/>
    <dbReference type="OMA" id="ITASHHI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="85" mass="9471" checksum="10BCBAC37AF7FB32" modified="2013-03-06" version="1">MAYGCRSIFLSIVDAIALTVSGKKLSTIVQKYDWVLKRVKGSHHIFDKEGLETTLSIPIHSNKDPKIGTLKAILKQANLTEDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z227</accession>
    <name>K9Z227_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase/aspartoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218508.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0638"/>
    <dbReference type="EnsemblBacteria" id="AFZ52777">
        <property type="protein sequence ID" value="AFZ52777"/>
        <property type="gene ID" value="Cyan10605_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0638"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.674"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062226_0_0_3"/>
    <dbReference type="OMA" id="QRLACDA"/>
    <dbReference type="OrthoDB" id="632656at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="374" mass="43125" checksum="00015EEE1171635B" modified="2013-03-06" version="1">MEANTQIIDLQSLASGDILQLKTYHFQGKNGTKKAYIQANLHGAEIVGNAVIYELIEFFSNLNIEQIEGEIILVPMCNPVGANQRNLFFSTGRYSPYDGLNWNRIFWDYIHESPDLDTFVKFNINLSKEEIYHNYLTNIINNFSHKIKEINNSRSLPFSEHLRNVLQSLSLNANYVIDIHSSSVSAIDYIYSFDRRQKSTDYFLLEYAILMNKYDGNAFDEAFLNPWLVLEKKLNHEGRNITFDVEAWTLELGSGMRVKEESVKKGVRGIINYLTYKNILKLELIKPQNKTKFVLKNNLKHYYAPQGGIIRNRLQAGAKIQQGDTLYQLLTFEKKERKPTIIDIQSADQGIIYDVSTNDTVNQGEYILGIFPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z267</accession>
    <name>K9Z267_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall assembly/cell proliferation coordinating protein, KNR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218553.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0685"/>
    <dbReference type="EnsemblBacteria" id="AFZ52822">
        <property type="protein sequence ID" value="AFZ52822"/>
        <property type="gene ID" value="Cyan10605_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0685"/>
    <dbReference type="eggNOG" id="COG4282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413903_0_0_3"/>
    <dbReference type="OMA" id="RTEYLCS"/>
    <dbReference type="OrthoDB" id="1525963at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="208" mass="24393" checksum="4A4F049CCC8C5EB1" modified="2013-03-06" version="1">MNWLDFLEKWSQETLEILLPLKENNISDLTESELEFLTTKTLLKPPATPSQIENLENRLRKKLPPSYKDFLRTSNGWIQLAMDAEDGILWSTEEVDWLIKQEPELVETWHNGRDNYVSDEKYFVYGKEQDCIDLRTEYLCSALALSPLIDSAIYLLNPQVVTNDGEWEAWFFGNELPGANRYPSFAQMMIAEKERVLYSLKDSCDYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z282</accession>
    <name>K9Z282_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219040.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1192"/>
    <dbReference type="EnsemblBacteria" id="AFZ53311">
        <property type="protein sequence ID" value="AFZ53311"/>
        <property type="gene ID" value="Cyan10605_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1192"/>
    <dbReference type="eggNOG" id="ENOG502Z83U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072542_0_0_3"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="329" mass="39124" checksum="35E4A0AA694BCF88" modified="2013-03-06" version="1">MDNKKRLIEHQKPEELEELLKYFENLFNPLEEKEISDIDLCDEPILYIMGCARSGSTLVYQYLTESGLFTYPTNFISRFYYAPYLGAKLQQMLIEYDFREEIFTKNKTSLFTSNLGKTKGVMSPHEFWYFWRRFFIFGDIQKLSPEVIKDVNTDKFIKDLRAFQSVKKLPLVLKGMILNWHIPLLSSLYENSYFLFVKRDIKTNANSLVRAREKFFGDAKQWYSFKPPNYHKVINLEPIYQTVWQVMVTNLAIETGLNSIDSTKVFTIDYEKFCQNPQSLLEELCHKWKKEMPSNMKNLPQYFDIKKHPNISLYNWDNILSKVENLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z283</accession>
    <name>K9Z283_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218234.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52503">
        <property type="protein sequence ID" value="AFZ52503"/>
        <property type="gene ID" value="Cyan10605_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0358"/>
    <dbReference type="HOGENOM" id="CLU_2805259_0_0_3"/>
    <dbReference type="OrthoDB" id="2214234at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7974" checksum="998C0D1342C6AFAB" modified="2013-03-06" version="1">MTKKRIDKSVINITSLTDETDEKTYWLKKKPEDRLKALEMMRVINYGEDATTARLQRFFEIAEFKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z287</accession>
    <name>K9Z287_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219045.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1197"/>
    <dbReference type="EnsemblBacteria" id="AFZ53316">
        <property type="protein sequence ID" value="AFZ53316"/>
        <property type="gene ID" value="Cyan10605_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1197"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_3"/>
    <dbReference type="OMA" id="NIWSRRI"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="106" mass="12638" checksum="69A024965FAF219F" modified="2013-03-06" version="1">MSKNKKQNSTSEDKQPSFPQVPGFSSQFKSDLQWWFKNDKKRAEKILDLVTEVMRNPFQGIGKPEPLKYMEGNIWSRRIDLEHRLIYRISATQIDFLACRFHYDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E4</accession>
    <name>K9Z2E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218461.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0591"/>
    <dbReference type="EnsemblBacteria" id="AFZ52730">
        <property type="protein sequence ID" value="AFZ52730"/>
        <property type="gene ID" value="Cyan10605_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0591"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113197_1_0_3"/>
    <dbReference type="OMA" id="LPMIALN"/>
    <dbReference type="OrthoDB" id="1682867at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="18524" checksum="084CD3A84B1DABF3" modified="2013-03-06" version="1">MTNHSYPPDKCTFELLSAYLDGEVTAQQREEVQDLLANDPEIQSLYRRLLYLRDEFQNLPTPQPEYSPQELSSTVFAKVDQENRRCKTYVWGGGAIAAVILATLGGILNGNRTLLLQMANRDSQLNSDENLVIALNEPVIALPANTEESLMIPLDQSLMDIIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F7</accession>
    <name>K9Z2F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-terminal processing peptidase-2</fullName>
            <ecNumber evidence="6">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0784"/>
    <dbReference type="MEROPS" id="S41.008"/>
    <dbReference type="EnsemblBacteria" id="AFZ52917">
        <property type="protein sequence ID" value="AFZ52917"/>
        <property type="gene ID" value="Cyan10605_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0784"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.825"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_0_0_3"/>
    <dbReference type="OMA" id="FNHQNWA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938563" evidence="4">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="46560" checksum="557521BE8DFBA20F" modified="2013-03-06" version="1" precursor="true">MSRESMKKIPYLLFAIILFLSTLFLNPANANAYTEEEKLLLQSWRLVNEAYVDDSFNNQNWWFIRQQFLKKPLHSKDEAYEAISEMLATLDDPYTRFLPPRQYQNLQITTSGELSGIGLQISINPEDKHLEVVSPLPNSPAEAAGIQPRDQILTIDGIDTETLTLDEAANKIRGKIGTLVTLEIKSKKEGIIKEYQLKRDRLSLSSVTARLDTSNPDYPIGYLRLNQFSGNASKDLAHELAKLDQKGAKAYILDLRNNPGGLLQAGIEIARLWLPPSTIVYTVNRQGIFGSYDATGNQLTDAPLVVLVNQGSASASEILAGALQDNQRATLIGETTFGKGLIQSLFELPDGAGIAITVAKYETPNHKDINKKGITPNVEVTQDPISYFEIGTEKDLQYQAAIAFLTENDSLPTMISQNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I6</accession>
    <name>K9Z2I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell division protein, required for chromosome partitioning (FstK)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0451"/>
    <dbReference type="EnsemblBacteria" id="AFZ52593">
        <property type="protein sequence ID" value="AFZ52593"/>
        <property type="gene ID" value="Cyan10605_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0451"/>
    <dbReference type="eggNOG" id="ENOG5034C8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600193_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9099" checksum="A4A76936901683F4" modified="2013-03-06" version="1">MNQNHSFEDYKNEIRCRKYSYTGRYFKSILTVIAICLMLIVIELASFMPVNASNSVIDVNIHQVGGRTIYRGIPVENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L5</accession>
    <name>K9Z2L5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPS (TC 1.B.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218541.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0672"/>
    <dbReference type="EnsemblBacteria" id="AFZ52810">
        <property type="protein sequence ID" value="AFZ52810"/>
        <property type="gene ID" value="Cyan10605_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0672"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.708"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021521_0_0_3"/>
    <dbReference type="OMA" id="TIRTPNF"/>
    <dbReference type="OrthoDB" id="956274at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="543" mass="61117" checksum="81D4A84D94021198" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L8</accession>
    <name>K9Z2L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1331"/>
    <dbReference type="EnsemblBacteria" id="AFZ53446">
        <property type="protein sequence ID" value="AFZ53446"/>
        <property type="gene ID" value="Cyan10605_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1331"/>
    <dbReference type="eggNOG" id="ENOG5032YW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106205_0_0_3"/>
    <dbReference type="OMA" id="NLHQFKQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="26573" checksum="6BCBF630E375B56D" modified="2013-03-06" version="1">MAEIDNFLQDIESKYQQKNQQVSKVNHNQLDREQKKSNNSDIDSFISEIESQKKVTENQDITEDIVLEIEGKFQQKKSSNSLNSTSNKKDNLISEIESKFNQKQSQSKIDSDDIISDIEKQYKQKQSAHKSQKKSGIAENYISELVTSYHQKQKEINHNKKSENLEEIRQQELEKQRQEKLITRKAEVWLKNLDPYSDEGFWFEQFALSYPTKLEAAIEYLKALSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W8</accession>
    <name>K9Z2W8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recG</name>
        <name evidence="9" type="ordered locus">Cyan10605_1445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219285.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1445"/>
    <dbReference type="EnsemblBacteria" id="AFZ53556">
        <property type="protein sequence ID" value="AFZ53556"/>
        <property type="gene ID" value="Cyan10605_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1445"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1532"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_3"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="417"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="597"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="828" mass="93534" checksum="60897717FF656592" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z304</accession>
    <name>K9Z304_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219268.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1428"/>
    <dbReference type="EnsemblBacteria" id="AFZ53539">
        <property type="protein sequence ID" value="AFZ53539"/>
        <property type="gene ID" value="Cyan10605_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1428"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1509"/>
    <dbReference type="eggNOG" id="COG3228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063037_0_1_3"/>
    <dbReference type="OMA" id="EHSGEAW"/>
    <dbReference type="OrthoDB" id="1806453at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20169">
        <property type="entry name" value="Peptidase_M90_mtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="32377" checksum="634D5BF2CE490394" modified="2013-03-06" version="1">MEKLILLTTLILAFLAYYYQTQIRINYRRKTLKQSSFPEEWIDFLSKYIYLYRIIPQELKQELHSHIKIFLHEKEFISYDKQPVNIETKLAIASQACLLLLGDKRQKRNYFPYLKYIYIYPNLIVQKKGEQMSAILSGQSSVGNKSGKDGVVSLSWQEVIKQSSSPHQIENVILHEFAHQLDQEFGTATGVPRLSNLQETLIWGEILKKEYEKHYQAVHKGRITIIDPYGATNMAEFFAVVTEAFFLKSKLLAAYHPLLYNQLSNYYGVNPIEWKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z312</accession>
    <name>K9Z312_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218706.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0843"/>
    <dbReference type="EnsemblBacteria" id="AFZ52975">
        <property type="protein sequence ID" value="AFZ52975"/>
        <property type="gene ID" value="Cyan10605_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0843"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.886"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086957_0_0_3"/>
    <dbReference type="OMA" id="MGLNPHR"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="24217" checksum="BD1F1386315E62D6" modified="2013-03-06" version="1">MSLNQFQVCEGDLSPEIFRQYSESDCLAMDTETMGLIPQRDRLCLVQVCDRNGLVTAIRIAKGQTEAPLLQKLLENPDITKIFHYARFDVAQFKHTFGVETNSIFCTKIASKIARTYTQSHGLKSLVQELEGVELDKKAQSSDWGNVNSLTSEQLSYAANDVRYLIPVKDKLITMLQREDRWSLTRRCFEAISLFVDLDLMYYNNVFEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B4</accession>
    <name>K9Z3B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1084"/>
    <dbReference type="EnsemblBacteria" id="AFZ53207">
        <property type="protein sequence ID" value="AFZ53207"/>
        <property type="gene ID" value="Cyan10605_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1084"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1147"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_3"/>
    <dbReference type="OMA" id="LYQPYAV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="358"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="596" mass="66344" checksum="1B4A7C1DE1C01DDE" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B8</accession>
    <name>K9Z3B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1090"/>
    <dbReference type="EnsemblBacteria" id="AFZ53212">
        <property type="protein sequence ID" value="AFZ53212"/>
        <property type="gene ID" value="Cyan10605_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1090"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1154"/>
    <dbReference type="eggNOG" id="ENOG5032S96">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162320_0_0_3"/>
    <dbReference type="OMA" id="ALANVDW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021995">
        <property type="entry name" value="DUF3593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35473">
        <property type="entry name" value="PTHR35473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12159">
        <property type="entry name" value="DUF3593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13524" checksum="982626F9CCE648B0" modified="2013-03-06" version="1">MVRVVKYQIIPNMESIINNLLSKENLFAISLFPYLGFLWFLTKSGKVPKLALIGFYLLLLFVAITIPAGLYAENHYHTTLANVDWLHGGAEFFLTLSNIFVVLGFRKMVITAENQNNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F4</accession>
    <name>K9Z3F4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1560"/>
    <dbReference type="EnsemblBacteria" id="AFZ53669">
        <property type="protein sequence ID" value="AFZ53669"/>
        <property type="gene ID" value="Cyan10605_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1560"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1657"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101699_0_0_3"/>
    <dbReference type="OMA" id="TPTYRGW"/>
    <dbReference type="OrthoDB" id="1430280at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="164" mass="18537" checksum="83581D0574841277" modified="2013-03-06" version="1">MFSAVSLNGCNSSNVSSFSTSLNSRYNDEQPAISGDGRWLAMVSNRNGRREILLYDLQLRNFVDLPGLNIGNAINDSPSLSRTGRYIAYISSIQGRPDIFIYDRATKQTQLVTQGYRSWLRNPRISPDGRYIVFETAKRGQWDIEVIDLGIRTELDRPDGEVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F9</accession>
    <name>K9Z3F9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219453.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1619"/>
    <dbReference type="EnsemblBacteria" id="AFZ53726">
        <property type="protein sequence ID" value="AFZ53726"/>
        <property type="gene ID" value="Cyan10605_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1619"/>
    <dbReference type="eggNOG" id="COG5607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073332_0_0_3"/>
    <dbReference type="OMA" id="MRVGMRR"/>
    <dbReference type="OrthoDB" id="1878295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="38604" checksum="6BAD0B2E607E1F21" modified="2013-03-06" version="1">MSSSTLNNNPTTIGDYAYGAISKHSHKIFKYEKKIFQENDPENLHQIRVAMRRLRSSLLSFDRVLILPSIICDRTVGKIARILGQERDVDIININLETKFKPNLPREEEKFLSKLEEEFNQKKHLHFPSSKYILKGKKYLKLKQALLDWLDIPELNKISALKTEKLLPDLLLPQIASFSLQSAWLTGTELENNHEIKLQYNLTDTEIKEILNQEGKYLHQLRKQAKKVRYQLELFTDFYPPKYQEYISFVKQLQTVLGNIQDNLCLMSYLSDLVGKKWEKNLPQLSLLIKEDQERQWREWQKLQSIFLSPNYLSHWREVIIKFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J7</accession>
    <name>K9Z3J7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="16" type="ordered locus">Cyan10605_0821</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218684.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0821"/>
    <dbReference type="EnsemblBacteria" id="AFZ52953">
        <property type="protein sequence ID" value="AFZ52953"/>
        <property type="gene ID" value="Cyan10605_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0821"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.863"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_3"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="15">
        <location>
            <begin position="1"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="939" mass="107044" checksum="105EFB7E84903102" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q5</accession>
    <name>K9Z3Q5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">Cyan10605_1658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219491.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1658"/>
    <dbReference type="EnsemblBacteria" id="AFZ53764">
        <property type="protein sequence ID" value="AFZ53764"/>
        <property type="gene ID" value="Cyan10605_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1658"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1760"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_3"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="58"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="252"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="44216" checksum="285B7451C7B5BF0A" modified="2013-03-06" version="1">MNEPDFNRAKQSIESTPKIKSPNGSHTNPNAGKKMRPKDESPDLNMNSNSITPSNIAKIKVIGVGGGGCNAVNRMIQSSVVGVDFWQINTDAQALAQSMTTYCLQIGQKLTRGLGAGGNPAIGQKAAEESRDEIAKALENTDLVFITAGMGGGTGTGAAPIVAEIAKDMGCLTVGVVTRPFTFEGRRRTNQADEGIRALESKVDTLIVIPNNQLLAVIPPETPLQESFRMADDTLRQGVQGISDIITIPGLVNVDFADVRAVMADAGSALMGIGIGSGKSRAKEGAIAAISSPLIESSIEGATGVVLNITGGKDLTLHEVNAAAETIYEIVDPNANIIFGAVIDEKMQGEVRVTVIATGFSGEKKNNPDRAKTIPSPPNLDSPTSENKETANNSPETDPQSISSGLDIPEFLQRRRFPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q9</accession>
    <name>K9Z3Q9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor, CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1266"/>
    <dbReference type="EnsemblBacteria" id="AFZ53382">
        <property type="protein sequence ID" value="AFZ53382"/>
        <property type="gene ID" value="Cyan10605_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1266"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1337"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_3_3"/>
    <dbReference type="OMA" id="WLACDKQ"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="140" mass="16062" checksum="DA0AC6F604AFD236" modified="2013-03-06" version="1">MSFLPKYRPQKLSLGFLEQEILEIIWDLGCASAKDIHDRILADPDRELAYASVMTVLQRLTKKGWLTHKKKGRAFFWYPLISREQAQAVQSYEQLHNFLAISNPEVVASFADSLDTASIEQIEAIATRLAEVRKQRGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T6</accession>
    <name>K9Z3T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219521.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1691"/>
    <dbReference type="EnsemblBacteria" id="AFZ53794">
        <property type="protein sequence ID" value="AFZ53794"/>
        <property type="gene ID" value="Cyan10605_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1691"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1794"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_4_0_3"/>
    <dbReference type="OMA" id="TFWPGAP"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="84"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="559" mass="64956" checksum="4752D3FC477B4AC6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U1</accession>
    <name>K9Z3U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219526.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1696"/>
    <dbReference type="EnsemblBacteria" id="AFZ53799">
        <property type="protein sequence ID" value="AFZ53799"/>
        <property type="gene ID" value="Cyan10605_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1696"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1802"/>
    <dbReference type="eggNOG" id="ENOG5032RNE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173130_0_0_3"/>
    <dbReference type="OMA" id="VNSGLWF"/>
    <dbReference type="OrthoDB" id="2032033at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9766" checksum="E6C7649E497F4622" modified="2013-03-06" version="1">MPPRWPRKPDRQNDPEFRKLDDRMNFAVHTALFIATNSGVWFFHNFNHPEWSWASQFSLIWGGILIVHFLYISAIADYSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y1</accession>
    <name>K9Z3Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219181.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1337"/>
    <dbReference type="EnsemblBacteria" id="AFZ53452">
        <property type="protein sequence ID" value="AFZ53452"/>
        <property type="gene ID" value="Cyan10605_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1337"/>
    <dbReference type="HOGENOM" id="CLU_164851_1_1_3"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9383" checksum="1169EE3CCA72E61A" modified="2013-03-06" version="1">MSKADRILAKMKLNPHDWRIENVKTVAQTYGIEWRQKSTFHVVFIRSDGKTLSIPAHRPIKPIYIKKFNIKKFINFVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y3</accession>
    <name>K9Z3Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219638.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1809"/>
    <dbReference type="EnsemblBacteria" id="AFZ53911">
        <property type="protein sequence ID" value="AFZ53911"/>
        <property type="gene ID" value="Cyan10605_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1809"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1920"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_11_0_3"/>
    <dbReference type="OMA" id="TILRDWS"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="23761" checksum="39F73371B7F0F164" modified="2013-03-06" version="1">MATFLRPLSYKYQWLYDTISRLAAIPVGGEKKFRELALLDLPITKESKILDLCCGAGQTTKFLINYSTNVTGLDISPLSLEKAKKNVPQAKYIEGFAQKMPLPDQYFDIVHTSVALHEMTTDELEAIFAEVYRVLKPEGIFTFIDLHKPHNPLFIPGIFAFMWLFETDTAWQLLKTDLSVKLIDSGFSILKQKLYAGGSLQVIQAKKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z418</accession>
    <name>K9Z418_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218854.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0994"/>
    <dbReference type="EnsemblBacteria" id="AFZ53123">
        <property type="protein sequence ID" value="AFZ53123"/>
        <property type="gene ID" value="Cyan10605_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0994"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1051"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_2_0_3"/>
    <dbReference type="OMA" id="KALRCQV"/>
    <dbReference type="OrthoDB" id="2067975at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="92" mass="10715" checksum="E83C63AB1FC6329F" modified="2013-03-06" version="1">MRKPNKIKNYRRCISCQKIDHKSNFFRVVKNNAQQIITVDQGMGRSAYICKNVDCVAIAEKKRLAKALKTSIPSDIYQQLWQKLKETKNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z423</accession>
    <name>K9Z423_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosyl-3-phosphoglycerate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218859.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0999"/>
    <dbReference type="EnsemblBacteria" id="AFZ53128">
        <property type="protein sequence ID" value="AFZ53128"/>
        <property type="gene ID" value="Cyan10605_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0999"/>
    <dbReference type="eggNOG" id="COG3769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063016_0_0_3"/>
    <dbReference type="OMA" id="GPEGWNE"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050531">
        <property type="term" value="F:mannosyl-3-phosphoglycerate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006381">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01142">
        <property type="entry name" value="C2.B.2:_Mannosyl-3-phosphoglyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01486">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="29972" checksum="AAF69B4B39092ADF" modified="2013-03-06" version="1">MLFIFTDLDGTLLNQNDYRYDDALPILEILKNKNIPVIPVTSKTKAEVESLCAEIGLNDPFITENGSGIFIPKDDFRFDTTQALTTESYNYISLGFEYHNARCILWEISQKLKTDLVGFGDLSPEDIVNLTGLSLNEAILAKTRNFTEPFLTPKHINPSLLQNIAQEYQATIVVGDRFSHLISAKAGKGNAVKWLLNNYHNLEEKITTIGLGNSPNDISLLESVDIPIIIPNPDGVHKGLKNKNWQVAPHSGSKGWSQVITEIILSHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z485</accession>
    <name>K9Z485_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1908"/>
    <dbReference type="EnsemblBacteria" id="AFZ54006">
        <property type="protein sequence ID" value="AFZ54006"/>
        <property type="gene ID" value="Cyan10605_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1908"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2025"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_2_1_3"/>
    <dbReference type="OMA" id="WGIAGFC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15130" checksum="0A558D74D3BB7B3F" modified="2013-03-06" version="1" precursor="true">MKKQSVIALISGLLFGLGLSISQMVDRERVLGFLDVAGKWDATLMFVLGGAVGVTLITFRFILKLKHPLFEQKFYLPSRQDIDLKLILGAVIFGIGWGIGGYCPGPAVTSLVQLSINPIIFILAFIIGSLGYEKIMGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D3</accession>
    <name>K9Z4D3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219331.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1491"/>
    <dbReference type="EnsemblBacteria" id="AFZ53602">
        <property type="protein sequence ID" value="AFZ53602"/>
        <property type="gene ID" value="Cyan10605_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1491"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112932_1_0_3"/>
    <dbReference type="OMA" id="AHYYFTF"/>
    <dbReference type="OrthoDB" id="1865810at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021256">
        <property type="entry name" value="DUF2808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10989">
        <property type="entry name" value="DUF2808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938657" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="19563" checksum="54731A802B203F08" modified="2013-03-06" version="1" precursor="true">MKFLKIITLLIISANTVIIPFSAHSQNDSQATFFTGKPPVFVGVKTPNSTVNLPDAHYYFTFTLPSNSIEAIAQITIQQQESPEMIALNIDNTSAFIGDQNNQGQTLTIQPSELSEGTGVNILFNPPVPPGTTFTVRLEAVRNPSQDTTYMYDVTVFPAGNNPTAFPLGVGRLSFYELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D8</accession>
    <name>K9Z4D8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">Cyan10605_1111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218964.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1111"/>
    <dbReference type="EnsemblBacteria" id="AFZ53233">
        <property type="protein sequence ID" value="AFZ53233"/>
        <property type="gene ID" value="Cyan10605_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1111"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1175"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_3"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="10937" checksum="64B31EEA5F60583B" modified="2013-03-06" version="1">MAAISINVSTVKPLGDRVFVKVSEAEEKTAGGIYLPDNAKEKPQVGEVVTVGEGKVNDKGERTPVEVKVGDKVLYSKYAGTDIKLGGDDYVLLSEKDILAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I6</accession>
    <name>K9Z4I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219374.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1538"/>
    <dbReference type="EnsemblBacteria" id="AFZ53647">
        <property type="protein sequence ID" value="AFZ53647"/>
        <property type="gene ID" value="Cyan10605_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1538"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1633"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_3"/>
    <dbReference type="OMA" id="GCESFHA"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="544" mass="61623" checksum="F8C16E611257D6B1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M6</accession>
    <name>K9Z4M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219819.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2000"/>
    <dbReference type="EnsemblBacteria" id="AFZ54094">
        <property type="protein sequence ID" value="AFZ54094"/>
        <property type="gene ID" value="Cyan10605_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2000"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2123"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_3"/>
    <dbReference type="OMA" id="RIAGHAF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="64"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="317" mass="37093" checksum="43EEEC28359122E0" modified="2013-03-06" version="1">MFYECSDLNSFLQDINHYYQEYNLQKKTRFFQYINMAKFSPFLSSLETEKDQNKKCHVFSMKFYESMEKALSKALVENQFELYYQPFICFNTRKIVAVEALIRWNHPYWGLISPDKFIPIAEKSGLILPLGEWIIREACLDIQEFLSYPLKLAINISPHQLQDTFFLRNMIKILQETKFYPQNLSLEITEGIFLENSTNVIKLMVKLKKMGISLALDDFGTGYAGLKYLNDFPFDVIKLDKSFIHNIARKSRQKAIVNSMVTLAKTLNLTVHVEGIENNDDLNWIISEGINQGQGYFFSPPLSINQLKSFLKIWVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R5</accession>
    <name>K9Z4R5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">minC</name>
        <name evidence="6" type="ordered locus">Cyan10605_1283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219127.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1283"/>
    <dbReference type="EnsemblBacteria" id="AFZ53398">
        <property type="protein sequence ID" value="AFZ53398"/>
        <property type="gene ID" value="Cyan10605_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1283"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1355"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_0_0_3"/>
    <dbReference type="OMA" id="ILVWGRL"/>
    <dbReference type="OrthoDB" id="1665744at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="30459" checksum="EE629A91D36F7EBB" modified="2013-03-06" version="1">MSIETENQDSLTESPTPPPLKLLSSKEQINLIKKGEIIEVNLPPVNKSEANQWGRIIDDFKIRLQKIDKSWQLGTKTVIKSGDRLLDIRQLSELEGILENIGLTLDIIITRRRQTAVAVASAGYSVKQESSLVTFSDTKKEKKEENQALTEPLYLKTTIRSGVEICHPSTIIIAGDVNPGATIIAGGDVLIWGNLRGIAHAGANGNKQALIMALKMLPTQLRIADLVARAPDNLPDNYIPEIAYISNEGIKINPAENFYRSYEFIADKNYWQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U0</accession>
    <name>K9Z4U0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ni_hydr_CYTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219469.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1635"/>
    <dbReference type="EnsemblBacteria" id="AFZ53742">
        <property type="protein sequence ID" value="AFZ53742"/>
        <property type="gene ID" value="Cyan10605_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1635"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1736"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104593_0_0_3"/>
    <dbReference type="OMA" id="MMKEEWL"/>
    <dbReference type="OrthoDB" id="1939393at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="237" mass="28034" checksum="ACC824899522CBD5" modified="2013-03-06" version="1">MKSNSKSPYQKLMLRILHNLQGLSVILAVITAFWTYNTYDGRWGKIAFLPDWKEIEGIHGTFGLWVLLILPIFIIYSIHKQAQKLIQKDSLDKLKLINKPIWWYSLHRLVNTFSIFALIFAVFSGKMMDEKWLPQGELNHYWYYLHLISLIIVVLAIAFHVLIIAKIGSFSFLLSIFKLDFREDENPKYWPNKIKSLPENYREIMINEWTKTPAYLKISEIVLIFTIILAWVISWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X0</accession>
    <name>K9Z4X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoamine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219357.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1521"/>
    <dbReference type="EnsemblBacteria" id="AFZ53630">
        <property type="protein sequence ID" value="AFZ53630"/>
        <property type="gene ID" value="Cyan10605_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1521"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1616"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_4_3"/>
    <dbReference type="OMA" id="PIHWAGT"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="454" mass="50810" checksum="CD8DAFA060836A86" modified="2013-03-06" version="1">MAHRYDCIIVGAGLSGLIAARNLQRAGKNVLVFEAQDYVGGRMLGKHIAPNQYIDLGGQWVGPTQDRFLALLDEYNIPRFPSPLQGKVVLIYNDKRQEFNGFFQGFAEGDRPNVPEEEWQDAMKAWKTFDELSQSLSPQYPEANEENKKLDSQTFAQWIQENTQTDFGRWYFAYMCRAVGFLGPAEPDEVSLLHVLWGNKSASQAEHPEAELIHDGAGQIPSKIVTELNNEIHLNEAVVKITQDDHGVEVTTLKGIYQANFVIVAMPPYLAGKITYHPPLPPIKQQLAQRFPMGTLAKLLISYETPFWRSQGLAGVGMGNTEWIELFADSSDPRSGKGVLATFVMGDRYHRWIKLTKSEQKSVVLSDLAKYLGQQALSPTTFDIQDWPSNQWVGGGYAAFMPPGVWTRFGQSINKPFNRIYWAGTEIAERWAGFFDGAIRTAEAAAEAVLKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z513</accession>
    <name>K9Z513_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219232.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1390"/>
    <dbReference type="EnsemblBacteria" id="AFZ53503">
        <property type="protein sequence ID" value="AFZ53503"/>
        <property type="gene ID" value="Cyan10605_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1390"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1468"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_0_2_3"/>
    <dbReference type="OMA" id="MTRAINW"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="33594" checksum="5D3B839F6C4A9923" modified="2013-03-06" version="1">MDFLRSLPIGIFIEKPISWLHKLDPRVKLAWLMSVILTPLLANPYWRIFLVIFLLLLTVLAKIPWRILKTQVSLLVFFLVIVFCVTIFSGDGFNLNYQPTLPPSTLPTPQPTDYRYVLLEIGNFTMTRRSLDLAIRVTTLIFTLVYSSNLFLLTTAPEKITAGIEDLLSPLRRFNLPITEIILTLTLALRFIPLVLEEAQNLIRSIKTRAINWKKLGFKKSMQIWLIVAEKLLQNILLRAEQIAIAIEARGFTNPHDHLVQWHELKMIKADFFALFSLIIFWFFRVIYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z536</accession>
    <name>K9Z536_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220016.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2205"/>
    <dbReference type="EnsemblBacteria" id="AFZ54291">
        <property type="protein sequence ID" value="AFZ54291"/>
        <property type="gene ID" value="Cyan10605_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2205"/>
    <dbReference type="eggNOG" id="ENOG5032SS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186984_0_0_3"/>
    <dbReference type="OMA" id="IWQKMLA"/>
    <dbReference type="OrthoDB" id="1986183at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9242" checksum="56CCF4914D15124A" modified="2013-03-06" version="1" precursor="true">MNIVIISMFLILLIPIYQAWQNEDIWQRMLAVSSISTKASIMILAISVFKDDWMMGVVGVLILTIGNAGLMLLAHLLKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B6</accession>
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        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
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        <name evidence="10" type="ordered locus">Cyan10605_2248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
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            <taxon>Cyanobacterium</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54334">
        <property type="protein sequence ID" value="AFZ54334"/>
        <property type="gene ID" value="Cyan10605_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2248"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2389"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="ERQRMTI"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="Type_1_exporter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="360"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="587" mass="65059" checksum="75C3F913CDD439FB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J0</accession>
    <name>K9Z5J0_CYAAP</name>
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        <submittedName>
            <fullName evidence="5">Sucrose phosphorylase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220175.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2368"/>
    <dbReference type="EnsemblBacteria" id="AFZ54451">
        <property type="protein sequence ID" value="AFZ54451"/>
        <property type="gene ID" value="Cyan10605_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2368"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2515"/>
    <dbReference type="eggNOG" id="COG0366">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021358_0_0_3"/>
    <dbReference type="OMA" id="PNATQFT"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009018">
        <property type="term" value="F:sucrose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11356">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="547"/>
        </location>
    </feature>
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        <location>
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            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
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        <ligand>
            <name>sucrose</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>sucrose</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="403"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>sucrose</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003059-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="642" mass="74784" checksum="1017C80CC8AF3136" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M2</accession>
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        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase, type 2</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219767.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1946"/>
    <dbReference type="EnsemblBacteria" id="AFZ54042">
        <property type="protein sequence ID" value="AFZ54042"/>
        <property type="gene ID" value="Cyan10605_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1946"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2068"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_1_3"/>
    <dbReference type="OMA" id="EIQNGEY"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="123" mass="13919" checksum="FCD8F264FCB40EDF" modified="2013-03-06" version="1">MSINSNFPESASSANIRTPPWGMVAVLEQGKNYRINKITVKPGHHISTQLHYHRSEHWVVVAGTAKVTFNGKEQLLLPKQSTYVPMNTRHRVENPGVVPLVMIEIQNGEYLGDDDIIRFPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W2</accession>
    <name>K9Z5W2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">Cyan10605_1662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1662"/>
    <dbReference type="EnsemblBacteria" id="AFZ53768">
        <property type="protein sequence ID" value="AFZ53768"/>
        <property type="gene ID" value="Cyan10605_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1662"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1764"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_0_3"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="258"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="549" mass="63214" checksum="93ECE43ED75E90E9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X5</accession>
    <name>K9Z5X5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuA</name>
        <name evidence="9" type="ordered locus">Cyan10605_1678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219510.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1678"/>
    <dbReference type="EnsemblBacteria" id="AFZ53783">
        <property type="protein sequence ID" value="AFZ53783"/>
        <property type="gene ID" value="Cyan10605_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1678"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1781"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_3"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="534" mass="58122" checksum="5CF14F3E11C6EA66" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z660</accession>
    <name>K9Z660_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phycocyanin, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219932.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2118"/>
    <dbReference type="EnsemblBacteria" id="AFZ54207">
        <property type="protein sequence ID" value="AFZ54207"/>
        <property type="gene ID" value="Cyan10605_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2118"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2251"/>
    <dbReference type="eggNOG" id="ENOG502Z85C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="TTQMQGP"/>
    <dbReference type="OrthoDB" id="1513296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006246">
        <property type="entry name" value="Phycocyanin_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01338">
        <property type="entry name" value="phycocy_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3 4" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2 4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="17718" checksum="51B59431C489D809" modified="2013-03-06" version="1">MKTPLTEAVSSADSQGRFLSSTEIQVAFGRFRQATASLQAAKSLTENSDKLIKGAAQAVYQKFPYTTQMQGANFAADQRGKDKCARDIGYYLRMVTYCLVAGGTGPMDEYLISGIEEINRTFDLSPSWYIEALKYIKANHGLSGDPAVEANSYIDYAINALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z674</accession>
    <name>K9Z674_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219952.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2140"/>
    <dbReference type="EnsemblBacteria" id="AFZ54227">
        <property type="protein sequence ID" value="AFZ54227"/>
        <property type="gene ID" value="Cyan10605_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2140"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2275"/>
    <dbReference type="eggNOG" id="ENOG502ZC3W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133074_0_0_3"/>
    <dbReference type="OMA" id="GNWLITI"/>
    <dbReference type="OrthoDB" id="1899366at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021256">
        <property type="entry name" value="DUF2808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10989">
        <property type="entry name" value="DUF2808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="178" mass="20209" checksum="F18DA2A4BD3F25DF" modified="2013-03-06" version="1" precursor="true">MTNLFKLNRKSIFATIALSATLVTGLPYLVFAQSNPGLTIFSGVDRKDILNYRLDFGGNAGQWDRYRLRIPGKKLTQGVDKFFISYPDYFDGKFDVNKIEVRAKNTTLPVREIIWDEESRIIEIALEEPLLESNQVELVFSNVKNPDNSGTFYFQGQILTPGQVPLRLSVGTWILSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z677</accession>
    <name>K9Z677_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220399.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2601"/>
    <dbReference type="EnsemblBacteria" id="AFZ54676">
        <property type="protein sequence ID" value="AFZ54676"/>
        <property type="gene ID" value="Cyan10605_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2601"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2762"/>
    <dbReference type="eggNOG" id="ENOG50331IB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171088_0_0_3"/>
    <dbReference type="OMA" id="DYYQSQI"/>
    <dbReference type="OrthoDB" id="2028017at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10718" checksum="B432CEA36BA4316D" modified="2013-03-06" version="1">MSQTITNQKQKNLSCHRLPLAVYREVAAHLRQVEGVSTQLLPQKAKDFDYLQSQVGGLSVSYPDQLEIETQVNSILAYYENKYGKWETVDDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H3</accession>
    <name>K9Z6H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220509.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2713"/>
    <dbReference type="EnsemblBacteria" id="AFZ54786">
        <property type="protein sequence ID" value="AFZ54786"/>
        <property type="gene ID" value="Cyan10605_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2713"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102971_0_0_3"/>
    <dbReference type="OMA" id="MEVTITA"/>
    <dbReference type="OrthoDB" id="1901659at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="19250" checksum="0CE08728E646BAC8" modified="2013-03-06" version="1">MRHLVVVNLLLNKSNQEKGVTLLEVVLVSVIVGIMAAMSVPNLLEEQRQQKVNEAFGKVRGALVEAQTNANRQSTDCTVELTKSGASGNPAGCVLEPFSVDTDIVSITKTDFSTTPTNITFSFTGTTGNADTLWIARKDFGGNVIESSAKCIVISTLGMIRTGINEGGNCVNVENKRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M8</accession>
    <name>K9Z6M8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">Cyan10605_2717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220512.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2717"/>
    <dbReference type="EnsemblBacteria" id="AFZ54789">
        <property type="protein sequence ID" value="AFZ54789"/>
        <property type="gene ID" value="Cyan10605_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2717"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2882"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_5_0_3"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="236"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="403" mass="45446" checksum="E38B36C69F44EA66" modified="2013-03-06" version="1">MTSDNFEWLYRGVTEVFPSQTDSQEESENLEQLCNRCDRPLRVKLGIDPTGTDLHLGHSIPFRKLRAFQDQGHTAVVIIGDFTAQIGDPTGKDKVRKQLSAEEVKQNAETYLQQLRPILDFDTPGRLEIRYNSEWLSKLDLAQIQELLATMTVQQMLAKEGFNNRYNQQTPIYLHEFLYPLMQGYDSVAVNADVELGGTDQKFNIAVGRDLQRHFGQKPQFGVLLPILIGTDGEQKMSKSLNNYVGLKEDALSMYSKLEKTPDALLPNYYELLTNFALTEIPENPREAQKLLAVEIISQYHGQEAALMAQKTALEIVSRQNMANAQAVPEFSLESVEFPAKLFYILNASGLVNSSGEGRRQIQGGSVRLEGDRISDVNITYDDPTQLKGKILQVGKKKFIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N3</accession>
    <name>K9Z6N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HtrA2 peptidase</fullName>
            <ecNumber evidence="2">3.4.21.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.108" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220517.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2722"/>
    <dbReference type="EnsemblBacteria" id="AFZ54794">
        <property type="protein sequence ID" value="AFZ54794"/>
        <property type="gene ID" value="Cyan10605_2722"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2722"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2888"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_2_3"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="317"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="391" mass="42010" checksum="DC09A53B6E9B2540" modified="2013-03-06" version="1" precursor="true">MRISKSIGQFVSHLTAIIVGVALTFSGMSHLSAQTLVNDGIVAQIPTTITEDSFVARAVEKTGNSVVRIDTEKTVTRSFDPFFDDPFFRQFFGDQFRNAVPRERVVTGLGSGFIIDNNGVILTNAHVVSGADRVTVTLKDGRSFQGEVKGADEVTDLAVVKINPQGQSLPVASLGNSDQVKVGDWAIAVGNPVGLDNTVTLGIISTLNRPSSEVGILDKRIDFLQTDAAINPGNSGGPLLNAQGEVIGINTAIRADAMGIGFAIPINKAKQLQGTLVAGKEVPHPYVGIQMVNITPELARKNNQDPNTTFLIPEVEGVLVMRVLPNTPAEAGGMRRGDVIIKVDNQPIKDANQLQKIVENTSINQSLRFTVIRNQQQLQLSLKTAQMRTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P2</accession>
    <name>K9Z6P2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54861">
        <property type="protein sequence ID" value="AFZ54861"/>
        <property type="gene ID" value="Cyan10605_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2794"/>
    <dbReference type="eggNOG" id="ENOG502ZP5B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215281_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="50" mass="5799" checksum="AE95D59EA484BF0B" modified="2013-03-06" version="1">MKIKNKYIIVILLLIITATIIPNYWQLGMTGMVGFFLAYLTKGIRVKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z2</accession>
    <name>K9Z6Z2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ordered locus">Cyan10605_2842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220631.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2842"/>
    <dbReference type="EnsemblBacteria" id="AFZ54909">
        <property type="protein sequence ID" value="AFZ54909"/>
        <property type="gene ID" value="Cyan10605_2842"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2842"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3020"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_0_0_3"/>
    <dbReference type="OMA" id="KPQQIAR"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="23791" checksum="179603C829559880" modified="2013-03-06" version="1">MASRQQPRRTARVLALLSLSQIRIKSDQLEDLEINDLILGAIRTLTIEVENTLETAADELNRSNDKIFKSETRTSDVSSARIMLKDAIALTQKAINRVGTIVEIPEFIQVSRETEVKQYAIDLISCIRNNKEEIDSLIDGLMTDWTVNRLTQIDANILRLAVAEMKFFQQDHKIAINEAIEIAKQYSDDDGYRFINGVLRKVSNKLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z700</accession>
    <name>K9Z700_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220690.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2909"/>
    <dbReference type="EnsemblBacteria" id="AFZ54971">
        <property type="protein sequence ID" value="AFZ54971"/>
        <property type="gene ID" value="Cyan10605_2909"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2909"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110624_0_0_3"/>
    <dbReference type="OMA" id="PHWELDG"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="19992" checksum="B2F22C662CE173FF" modified="2013-03-06" version="1">MDLSDSSLKIKRRFLPHWELDGSIYFITFNTYQHLELNPSAREIVLNCCLFFDESRHQNDKRYHTFTIVIMPDHVHWLMQPLPKSNGEYWSLSSILHSVKSYSSKQIPKVMNHQGIVWQDERFDRIMRNEKEFLNTWQYIQLNPVKANLAKTPEEYPFFWQETHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z733</accession>
    <name>K9Z733_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220730.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2949"/>
    <dbReference type="EnsemblBacteria" id="AFZ55011">
        <property type="protein sequence ID" value="AFZ55011"/>
        <property type="gene ID" value="Cyan10605_2949"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2949"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3138"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022738_2_0_3"/>
    <dbReference type="OMA" id="NISETEH"/>
    <dbReference type="OrthoDB" id="1214117at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="PTHR11767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="12">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="IRK_C" evidence="13">
        <location>
            <begin position="136"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="291" mass="33239" checksum="9CA32ACA48449244" modified="2013-03-06" version="1">MGKRKKSLSVVKKKGNNFIELGKAWFDWGDIYHFLLTISWASFFSLIIFAYLILNGIFAIAYMSVSEGINNVRPNSFLDAFSFSVQTMATIGYGAMYPESLPAHTLVAIEVFIGLLGLAMITSLMFVRFSRPTARVLFSKVAVICPYNGVPTLMFRVANLRNNWIVEAQVRVSLLMPDTTTTEGYTMRHLVDLSLVRSQTPFLALTWMIMHPINSNSPLFSINQEEFLREDYQIFITLMGFDGTLSQTIHGRHIYFNQDIIWDHHFVDVVRITPDGNRYIDDAKFHDILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A3</accession>
    <name>K9Z7A3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ordered locus">Cyan10605_2962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220743.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2962"/>
    <dbReference type="EnsemblBacteria" id="AFZ55024">
        <property type="protein sequence ID" value="AFZ55024"/>
        <property type="gene ID" value="Cyan10605_2962"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2962"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3153"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_3"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="176"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="453" mass="50672" checksum="53CF23BAB9206EC3" modified="2013-03-06" version="1">MLPIVAIIGRPNVGKSALVNRLCGEQDAIVFDQPGVTRDRTYRRAFWQDREFQVVDTGGLVFDDETEFLPLIREQAEAALSESVVAIFVVDGKLGLTAGDEEIASWLRSQPVPVVLAVNKCESETQGLTLAAEFWNLGLGEPFPISAIHGNGTGDLLEKVTEYVPSMDEWEEVEETKVAIVGRPNVGKSSLLNALTGEKRAIVSPISGTTRDAIDMVVERDGKTYRLIDTAGIRRKKNVDYGTEFFSINRAFKAIKRADVVLFVIDVLDGVTEQDLKLAGRIIDEGKAAVIVVNKWDAVEKDTHTIYEYQKIIGDRLYFMEWADRVFTSAMTGKRVDKILDLIDTAAEGHQKRVSTSVINEVIEDAVRWHSPPTSRQGKQGKIYYGTQVTSKPPTIALFVNDPKRFNDSYRRYMEKQFRQQLGFHGTPLKLLWRGKSLREGEKMGSSNRATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D2</accession>
    <name>K9Z7D2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2197"/>
    <dbReference type="EnsemblBacteria" id="AFZ54283">
        <property type="protein sequence ID" value="AFZ54283"/>
        <property type="gene ID" value="Cyan10605_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2197"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341412_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="204" mass="23428" checksum="ADE19237BC997A28" modified="2013-03-06" version="1" precursor="true">MLTILSVLLFLLSFIHFCLAVTLMGECLASALNIKKDENFNDKWLHTSVSVLIPAHNEERVISQTLKTIIPQLKSTDNIIVIADNCTDCTVAVVENMGVKIIERQNDLLKGKGYALDFGVNYLRENPPDVVIFIDADCNVEQNAIASLLIFFGIFIAWVKFAREELTLTTLMKIPLYILWKIPLYFKFLFKRENQWIRTERDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D3</accession>
    <name>K9Z7D3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220209.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2403"/>
    <dbReference type="EnsemblBacteria" id="AFZ54485">
        <property type="protein sequence ID" value="AFZ54485"/>
        <property type="gene ID" value="Cyan10605_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2403"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2549"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029604_0_0_3"/>
    <dbReference type="OMA" id="HEYGKYV"/>
    <dbReference type="OrthoDB" id="1000882at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="431" mass="49743" checksum="15A7100F9BA9F1B1" modified="2013-03-06" version="1">MNGNTAIFYDVENLLKGYNMPKNYINSISLKNIFKEVEKIPKVKRILVQKAYANWSDSRLSVMKREINELGIEPVQIFGFSYYQKKNAADIQLAVDAIDLAYVRNNIDIFVIVSGDGGFSAVARKLHEYGKYVIACGYKSSTNQVLESMCDYFIGIDDPEEENENITEEKKEVEQNLKITNPLVLKMSQSLERLSSNNREEIIKKSQIILNWFTQDKEAVRELSHSGIHLSVIKEAFKYGIEDFDPHKIGLPKFIQFLQYICKDTDLKIVTSDKFQTKLALKNTILENFEPLPYLDDNFLHSSENYQSILAIGNPRIKIIDSEDFLKITSAVACLTDEYTLDILLENINNIYPDIESENINNCLLSLINLDIFAITNSHKHISEKVFRLKLEFQEHKAIIKKFKESIFNKLSSFWGKDLKENIIEQIILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J1</accession>
    <name>K9Z7J1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">Cyan10605_2273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220082.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2273"/>
    <dbReference type="EnsemblBacteria" id="AFZ54358">
        <property type="protein sequence ID" value="AFZ54358"/>
        <property type="gene ID" value="Cyan10605_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2273"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2414"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_3"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="21993" checksum="9E2DDA21F68FB4A1" modified="2013-03-06" version="1">MNQQEKRGKLIVITGPSGVGKGTIVKQLLAKHSQIFISTSATTRKPREGEIHGQDYFFLSQDEFKQMIDNSQLLEWAEYNGNYYGTPKQPVIEQIEQGKIVILEIEVLGARQVKETFPDALRIFILPPSEAELERRLRGRGTDSESAIIKRLEKAKFELSTCNEFDYQVINDQLENAIASVEKIITGVRGFFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L3</accession>
    <name>K9Z7L3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220890.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55171">
        <property type="protein sequence ID" value="AFZ55171"/>
        <property type="gene ID" value="Cyan10605_3119"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3119"/>
    <dbReference type="eggNOG" id="ENOG5032Z74">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199719_1_0_3"/>
    <dbReference type="OMA" id="EANFVEM"/>
    <dbReference type="OrthoDB" id="2069326at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7684" checksum="3B8EE90C3D3CDC14" modified="2013-03-06" version="1">METATLKEMIKESIREVLHEERLSLIQSLIPPVNDEEMKEIEGKFGHPHNYNEANFVEMNDWLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U9</accession>
    <name>K9Z7U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220979.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3214"/>
    <dbReference type="EnsemblBacteria" id="AFZ55261">
        <property type="protein sequence ID" value="AFZ55261"/>
        <property type="gene ID" value="Cyan10605_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3214"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_21_0_3"/>
    <dbReference type="OMA" id="LVWLFER"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938701" evidence="3">
        <location>
            <begin position="28"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="44"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="44"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="42444" checksum="071DC80E23713671" modified="2013-03-06" version="1" precursor="true">MILKNKFLLINTLILLISNIFPNSCLSQETINNKINQPINSETNLKVITNSFPPLVIIDQEKYTGFSIELWDAIASELNIDYTIKRKNNVQELIDGVMAGEADVAIAGISMTSEREKIIDFSHPIFESGLKILVSGKQASPFVVFLRSFFSPILWNTMGFLVIVTIICAHLMWFLERKKNSEMFPQKYFKGIWESFWWSIVTLVTVGYGDKTPITFGGRLLATLWMFTGILLISYFTASVSSDLTLHRIQANIHSYHDLRDKKVGTLANTTSANFLQMIGAEVITYNSIHKAYSALKNQEIRAIVYDAPVLMYYAKQDTKYNLQVVGHVFEPQDYAIVLQLNSIYRQPINEAILTLKENGTYNEIYQKWFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W5</accession>
    <name>K9Z7W5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220942.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3173"/>
    <dbReference type="EnsemblBacteria" id="AFZ55224">
        <property type="protein sequence ID" value="AFZ55224"/>
        <property type="gene ID" value="Cyan10605_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3173"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_8_2_3"/>
    <dbReference type="OMA" id="VGPWFPL"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="22975" checksum="760ABF98ABD506E9" modified="2013-03-06" version="1">MKGKLIVVTLILICLTGVSIVWMGGIQPEILHEQVKRLGIFAPIIYVLLYIVATILLLPSTPLNISGGLIFGFQWGLFWTAIAAIMAAIASFIYARFLGQNWVRQKFGSYLQNLDEEIRKGGIWYIFAIRLLPLIPYGIVNYGAGLTSVTQKDYLFGTIFGTIPGIFPFVMIGAGLAEGSILPVTIASGLASLLLFGATWFKNKSKGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z860</accession>
    <name>K9Z860_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220478.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2681"/>
    <dbReference type="EnsemblBacteria" id="AFZ54755">
        <property type="protein sequence ID" value="AFZ54755"/>
        <property type="gene ID" value="Cyan10605_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2681"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2846"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012236_1_0_3"/>
    <dbReference type="OMA" id="EVWCVLE"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="421"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="630" mass="70995" checksum="D9EB6F7C195BE252" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z880</accession>
    <name>K9Z880_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase</fullName>
            <shortName evidence="6">Mg-protoporphyrin IX monomethyl ester oxidative cyclase</shortName>
            <ecNumber evidence="6">1.14.13.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acsF</name>
        <name evidence="8" type="ordered locus">Cyan10605_2707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58632"/>
            <dbReference type="ChEBI" id="CHEBI:60491"/>
            <dbReference type="EC" id="1.14.13.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AcsF family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.81" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220503.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2707"/>
    <dbReference type="EnsemblBacteria" id="AFZ54780">
        <property type="protein sequence ID" value="AFZ54780"/>
        <property type="gene ID" value="Cyan10605_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2707"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2872"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048037_0_0_3"/>
    <dbReference type="OMA" id="FHPIFKW"/>
    <dbReference type="OrthoDB" id="366541at2"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048529">
        <property type="term" value="F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036068">
        <property type="term" value="P:light-independent chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01047">
        <property type="entry name" value="ACSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01840">
        <property type="entry name" value="AcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008434">
        <property type="entry name" value="AcsF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31053">
        <property type="entry name" value="PTHR31053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02029">
        <property type="entry name" value="AcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="7">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="358" mass="42325" checksum="5ADCE7B2C5615672" modified="2013-03-06" version="1">MVTTVRPSEFEEIRPGVKAPAKETILTPRFYTTDFEEMAKMDLSANEEELKAILAEFKEDYNRHHFVRNADFDQSWDHIDGETRRLFVEFLERSCTAEFSGFLLYKELGRRLKDTNPLLAECFLLMSRDEARHAGFLNKALSDFNLTLDLGFLTKSRKYTFFKPKFIFYATYLSEKIGYWRYITIYRHLEQHPESRIYPIFKFFENWCQDENRHGDFFDAILKAQPSFLNDWKAKLWCRFFLLSVFATMYLNDLQRSDFYASIGLDARSYDKHVIEKTNNTAARVFPVIIDVDNPAFYESLEICVSNCEQLRAIDETNAIAPVKFLRKLPLYLSNMTQFIKLYFIKPIEVEKQQGCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z889</accession>
    <name>K9Z889_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221129.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3369"/>
    <dbReference type="EnsemblBacteria" id="AFZ55411">
        <property type="protein sequence ID" value="AFZ55411"/>
        <property type="gene ID" value="Cyan10605_3369"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3369"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3587"/>
    <dbReference type="eggNOG" id="COG0429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_793843_0_0_3"/>
    <dbReference type="OMA" id="FWFTGYS"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="353" mass="40471" checksum="3348F27911E4C28A" modified="2013-03-06" version="1">MWYYEPSIFLRSGLIQTLYVALFAHRNWHKTIKYSEPNYQEHIFYGANNVAIYGLVAIPPHAQGTIIATYGVTGSLQDQWFLKILSAKAYAQNYAVVMFDWRAHGKTALLSPTLTSDGLYEGQDFLCIASESKKLGCPPQFWFTGYSLGGKLTLWALYEASHLSKYEDSLELSEEDIGGGCAICPSLDAWKSLNYLEAHPVGSKLEKAITRNLRQLAEKIFQAHPHHFNQQQLDRVNSIKEFDRNLVIPQLGIDSLEEYYRLSSPLGIMAQIKKPTLILYAKDDPMFAPCLIEEVVKVSKNNPWIDLTLTKYGGHVGYISSKNCQKQWNDQDKWWAWNRFLEWITDSQKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A2</accession>
    <name>K9Z8A2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220528.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2733"/>
    <dbReference type="EnsemblBacteria" id="AFZ54805">
        <property type="protein sequence ID" value="AFZ54805"/>
        <property type="gene ID" value="Cyan10605_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2733"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2899"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_0_3"/>
    <dbReference type="OMA" id="SGSVKCR"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13312" checksum="5B2CF3C016286C05" modified="2013-03-06" version="1">MSLNIVHLVGRTGTDPEIRYFDSGSVKCRLTLAVNRPTKKDDPPDWFELEIWGKTAEVAANYAKKGSLIGVQGSLKIDTWSDRTTGENRSKPVIRVDKLDLLGSKRDNENYNQNNDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B7</accession>
    <name>K9Z8B7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220341.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2538"/>
    <dbReference type="EnsemblBacteria" id="AFZ54618">
        <property type="protein sequence ID" value="AFZ54618"/>
        <property type="gene ID" value="Cyan10605_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2538"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2693"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_1_3"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
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        <property type="entry name" value="PTHR11101"/>
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    </dbReference>
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        <property type="entry name" value="PHO4"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="37066" checksum="8877FACCC8020ED9" modified="2013-03-06" version="1" precursor="true">MNLITTLIFLSSGLFLGWSLGANDASNVFGTAVGSRMIRFSTAATICSVFVIIGAVTGGAGAAHGLGELGKVNALPGSFTVALGAALTVLWMTKLGLPVSTSQAVVGAIIGWNWFSGSPTDFQSLGKIVSTWILCPILAGVFSYGIYQIVVILIERTKPHLLSLDSNVRWGLILVGAFGSYTLGANNIGNVMGVFISASPFKDINIAGVTEISSVEQLFLLGSIAIAIGVFTYSKKVMMTVGDSLMALSPVGALTVVLANSLVLFIFSSKALSNFVVNLGLPAIPLIPVSSSQAVVGAVIGIAFCKGFKGVRQIKWGVLGEIASGWITTPIISAFIAFILLFIVQNVFDQQVYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I6</accession>
    <name>K9Z8I6_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_2833</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Oscillatoriophycideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2833"/>
    <dbReference type="EnsemblBacteria" id="AFZ54900">
        <property type="protein sequence ID" value="AFZ54900"/>
        <property type="gene ID" value="Cyan10605_2833"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2833"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3011"/>
    <dbReference type="eggNOG" id="ENOG5033D0R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201702_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="51" mass="5829" checksum="59CC49316EF87FBD" modified="2013-03-06" version="1">MKDLDRENDNLNNCSQNQDQKQEEKILCPHCKRTATNGIKCKGICVADSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K4</accession>
    <name>K9Z8K4_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_3457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3457"/>
    <dbReference type="EnsemblBacteria" id="AFZ55494">
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        <property type="gene ID" value="Cyan10605_3457"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502ZDPJ">
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    </dbReference>
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    <dbReference type="OMA" id="IAHIVIL"/>
    <dbReference type="OrthoDB" id="2086152at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11778" checksum="4E1499910C13BEE6" modified="2013-03-06" version="1">MSLIFILSFNIFICVINFYLLWQLIRIKKYLKTLNTRLIYINKNLPLIIKEVSLSILTTALEIKKIKEKYRRLKNNISNVQKILTISRIIYKIVYQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P0</accession>
    <name>K9Z8P0_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0150</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_3034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55092">
        <property type="protein sequence ID" value="AFZ55092"/>
        <property type="gene ID" value="Cyan10605_3034"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3034"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3231"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_2_1_3"/>
    <dbReference type="OMA" id="YSATCPE"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7639" checksum="0D758AF679915A4C" modified="2013-03-06" version="1">MIVKAILEWDEEAQSYSATCPELNYISSCGDTKEEAIENLKDAIQLLLEPIPEISSNTDINNRIEILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R8</accession>
    <name>K9Z8R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2674"/>
    <dbReference type="EnsemblBacteria" id="AFZ54748">
        <property type="protein sequence ID" value="AFZ54748"/>
        <property type="gene ID" value="Cyan10605_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2674"/>
    <dbReference type="eggNOG" id="ENOG5032YHW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174642_0_0_3"/>
    <dbReference type="OMA" id="PQECFVP"/>
    <dbReference type="OrthoDB" id="1866408at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8595" checksum="3DDE14BA712F2396" modified="2013-03-06" version="1">MKNGVPELLDPNLLKSAREIYNTYRYFHVKLSKPPIGVAINRKTHRGQLLFTKRPILLPWENFIPIHQIESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V5</accession>
    <name>K9Z8V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrous iron transport B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">PCC 10605</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="AFZ55152"/>
        <property type="gene ID" value="Cyan10605_3099"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3099"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3302"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
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        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
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            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
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            <end position="446"/>
        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ55152.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="487" mass="54942" checksum="62DF7F7805A3CB5C" modified="2013-03-06" version="1">MSANINYPNIIEKGLAKIEDLLVQEAELFLQKNYLISRRSLALLIIQEDREIIIDLQKYLPSISPIEEIIYDVQTQLGKSITEAIAFTRQQKALEIEQQVLQDNSDSQRGIGEKLHQWMINPLTGFPILALVLYYGIYQFVGNFGAGTLVDLIEGFFEENINPFVNHIVAQIFPWVVIQDLFANDYGIITLGIRYATAIILPIVATYFLMFSLLEDTGYLPRLSLMLDRVFKTMGLSGRAVIPIVLGLGCDTMATVVTRTLETKRERIIATFLLALAIPCAAQWGVILGLLAKNPLALSIWAVVVLGIFLLAGFLTSRFLPGKPAQFYMEVPPLRMPKIENIITKTVIRMKWYFWEIIPLFIYASILIWFGKLTGLFDLIISWINPITLALDLPEEVSPIFLYGFFRRDYGAAGLFDIQSNAGLTGNQLVVCAIILTLFLPCIAQFQVMLKERGWKTTLAMVSFIFPFAFFVGYLVNQGLNIINLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z950</accession>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane sensor protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_3199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="Cyan10605_3199"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3199"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="VMGVAVC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="28"/>
        </location>
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        </location>
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        </location>
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            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="26762" checksum="B24D47539E6A5B70" modified="2013-03-06" version="1">MNITYDIPLVILSAIVAVGAGFFTIEMSNEIVLNKGIERWTWLIISAITMGMGIWGMHFIAMTAFSMGVEVSYDFLIVVISLLAAIIGCVQGLYIITQPLVNLKTLLAASITMGVAIAGMHYIGMAAMRVPGTINYDPIIFTLSVIIAIVVSFAAMKIVISLRQMKKNSRYSLYKVIASLIMGGAVLSMHYTGMAAAKFKIDVSSLLSLSQANFLDSEVIGSSVGITVIGMFAIIYIVLLNASWNRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A9</accession>
    <name>K9Z9A9_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">UDP-sulfoquinovose synthase</fullName>
            <ecNumber evidence="2">3.13.1.1</ecNumber>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_3266</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="3"/>
            <end position="291"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ55312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="43417" checksum="7644A1B0CB812626" modified="2013-03-06" version="1">MKALVIGGDGYCGWATALHLSNKGYDVAILDNLARRHWDDKLGVNTLTPIASIQKRINRWYELTGKKIELFVGDITNYDFLIKAFRKFEPESIVHFGEQRSAPYSMIDREHAVFTQVNNVVGTLNILYAMKEEFPDSHLVKLGTMGEYGTPNIDIEEGYIEIEHNGRKDILPYPKQPGSFYHLSKVHDSHNIHFACKIWGIRATDLNQGVVYGVLTEETGMDELLINRLDYDGVFGTALNRFCIQAAIGHPLTVYGKGGQTRAFLDIRDTVRCMELAIANPAEAGQFRVFNQFTELFSIKDLATMVQKAGATLGLKVEINNLENPRVELEDHYFNAKNTKLLDLGLQPHYLSDSLLDSLLNFANKYKGRVDMEQILPKVSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C6</accession>
    <name>K9Z9C6_CYAAP</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
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            <taxon>Cyanobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220894.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55175">
        <property type="protein sequence ID" value="AFZ55175"/>
        <property type="gene ID" value="Cyan10605_3124"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3124"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_1_3"/>
    <dbReference type="OMA" id="TDICGAC"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="35108" checksum="4223373A0C92A78E" modified="2013-03-06" version="1">MKINTLVIIKRKPWFREAFRVKYSVFPDVWEKALFFAIFSFVICLLHSVGFPVQQPILSSLIPTIVLGLLLVFRTNSANERFWEGRKLWGGIVNHLRNLTWQIWVNIKEETPQDQEHKINALNLLTVFAIATKNHLRSEGISEEMRPLLSAYYYHHLQTSQHLPLQIAAYLGEYLQQEYQKKHLNEYQLTNMQQLINQLMDMVGGCERILKTPIPNSYSIHLKQLLLIYCLVLPFQLVDQIEWWTIPFVSIVSYIVYGIEAIALEIENPFGRDRNDLPLDQICQAINQNIQDFILNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T3</accession>
    <name>K9Z9T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220852.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3076"/>
    <dbReference type="EnsemblBacteria" id="AFZ55133">
        <property type="protein sequence ID" value="AFZ55133"/>
        <property type="gene ID" value="Cyan10605_3076"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3076"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3279"/>
    <dbReference type="eggNOG" id="ENOG502ZT4I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116764_0_0_3"/>
    <dbReference type="OMA" id="KWGIRFR"/>
    <dbReference type="OrthoDB" id="1753404at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019664">
        <property type="entry name" value="Uncharacterised_Ycf51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10726">
        <property type="entry name" value="DUF2518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="19758" checksum="70EB0B82762AE344" modified="2013-03-06" version="1">MDLSLDFSTYTLWSVYGTIAFLLLAILGFIFKWGFRFRFVGATGFMAVLTVGLFALSLGLFERVEIPNALRYNLVYDTGTNQAVIAVEEDITKTELEATLQQAAIDLFSYGRTASNGDDQLTIRARVQIHKENITYPLYLGQIRRSLITREDDNPEITIFQDSLRKRQSLINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T9</accession>
    <name>K9Z9T9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_3305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221068.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3305"/>
    <dbReference type="EnsemblBacteria" id="AFZ55350">
        <property type="protein sequence ID" value="AFZ55350"/>
        <property type="gene ID" value="Cyan10605_3305"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3305"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3519"/>
    <dbReference type="eggNOG" id="COG0068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_3"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="203"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="788" mass="89813" checksum="A9C2CCA4A7BB53DF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9U6</accession>
    <name>K9Z9U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220862.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3087"/>
    <dbReference type="EnsemblBacteria" id="AFZ55143">
        <property type="protein sequence ID" value="AFZ55143"/>
        <property type="gene ID" value="Cyan10605_3087"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3087"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_1_3"/>
    <dbReference type="OMA" id="INDQWRL"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="11569" checksum="A08CB8A894AE0C80" modified="2013-03-06" version="1">MIKSFKNKGTEDIFYGENSKLARKTCPQNLWQIARRKLDQLDSIISLAELKIPPGNQFEPLKGDRDGQYNIRINQQYRICFSWQNNHIWEVEIIDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y0</accession>
    <name>K9Z9Y0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)H-quinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="7">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H dehydrogenase I, chain 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NDH-1, chain 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ndhD</name>
        <name evidence="9" type="ordered locus">Cyan10605_3353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221113.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3353"/>
    <dbReference type="EnsemblBacteria" id="AFZ55395">
        <property type="protein sequence ID" value="AFZ55395"/>
        <property type="gene ID" value="Cyan10605_3353"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3353"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3571"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_3"/>
    <dbReference type="OMA" id="QSNMKRR"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00491">
        <property type="entry name" value="NDH1_NuoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022997">
        <property type="entry name" value="NADH_Q_OxRdtase_chain4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="3 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="133"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="549" mass="60133" checksum="A090E3A20ED4BF1A" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y4</accession>
    <name>K9Z9Y4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease RNase T and DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221250.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3498"/>
    <dbReference type="EnsemblBacteria" id="AFZ55532">
        <property type="protein sequence ID" value="AFZ55532"/>
        <property type="gene ID" value="Cyan10605_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3498"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010909_0_0_3"/>
    <dbReference type="OrthoDB" id="1748607at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="70"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="29821" checksum="2526948B59B4E7A5" modified="2013-03-06" version="1">MITRKYTLLLFDIKDSNSVKSKRQLTKKQKLGLEKGRIKREIKQFLNHEYDRILDYNRAVKWANKWRNDKFLILDTETTGLENTEIIEIAVINQDKQILINTLVKPACFIPYEVIKIHSITNEMVADAPCFTNIYDRLKEILSNQNVLIYNTSFDHPIINSECRRNELPRINFNSHCLMEMYAIFMGEYSGYYDDYKWQPLNGGHRALDDCLRAFEVLEEMADSTIDIVEYLYDIFSDSILTKEEICHCYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA47</accession>
    <name>K9ZA47_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease (SNase domain-containing protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221307.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3559"/>
    <dbReference type="EnsemblBacteria" id="AFZ55592">
        <property type="protein sequence ID" value="AFZ55592"/>
        <property type="gene ID" value="Cyan10605_3559"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3559"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_7_2_3"/>
    <dbReference type="OMA" id="FTVRFAC"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="19728" checksum="366C331FBD4115E1" modified="2013-03-06" version="1">MNKIIGFFIFIFCVYSVFDALSNSPSEEFTQYQISSVHDGDTMRVRRPENEELKVRFACIDAREIGQQGGRSDLNFLISLLQTHDNRVKLQIMGKDRFGRTIAVVWAGNVLVPLAQVEAGQAFVYHRYKDDCPYYQEIKEAEAIAQKNKVGLWGEKIEYPWEWRRRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA65</accession>
    <name>K9ZA65_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220971.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3205"/>
    <dbReference type="EnsemblBacteria" id="AFZ55253">
        <property type="protein sequence ID" value="AFZ55253"/>
        <property type="gene ID" value="Cyan10605_3205"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3205"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="KQGVKAY"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="13400" checksum="22E8FB0D04C93EB1" modified="2013-03-06" version="1">MSKVLLVDDMKAELDLLHQYLTEAGYDVTTANNGKEALEMVDNNKPDIIVTDWMMPEMGGLDLCRQLKKNPNTATIPVVACTAKNRDVDKMWATKQGVKAYVIKPCTKEDLVNAVKSAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAB4</accession>
    <name>K9ZAB4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221026.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3262"/>
    <dbReference type="EnsemblBacteria" id="AFZ55308">
        <property type="protein sequence ID" value="AFZ55308"/>
        <property type="gene ID" value="Cyan10605_3262"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3262"/>
    <dbReference type="eggNOG" id="ENOG5031B15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105768_0_0_3"/>
    <dbReference type="OrthoDB" id="2056953at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="27728" checksum="18495AF48BB9C6AB" modified="2013-03-06" version="1">MKKQITFYFYIFLFNIFNLTINNIYVAYSFSLYSNNFIAQDTDNFNKIGEALGDLDNDSIPEKVVVYDTNKETEFGTQREIHIFKKTEDSWTLWEKNTGAVLPSKHGGVWGDPFQEINIENGAIKIYHFGGSRYKWQYIHQYKYLENDWKLIEATVEFGAFCDYYETLNYNLITGNIIYKKEEEKCDRANNINQEKEIVESLEFTQKLEQPPNMNGFYPGNNEIVIPQNNTTIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAF4</accession>
    <name>K9ZAF4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221290.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3542"/>
    <dbReference type="EnsemblBacteria" id="AFZ55575">
        <property type="protein sequence ID" value="AFZ55575"/>
        <property type="gene ID" value="Cyan10605_3542"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3542"/>
    <dbReference type="eggNOG" id="ENOG5033AW5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192651_0_0_3"/>
    <dbReference type="OMA" id="LRIIAWQ"/>
    <dbReference type="OrthoDB" id="2069049at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="108" mass="12795" checksum="62B52AA72E1B8ABC" modified="2013-03-06" version="1">MAINIPNRNTKILSQLIDGLRIIAWQEYKNENRDSEVKGLDLYELFKEEWVNHEIHKMSLAELNKFMAELRYTQADLAGVRSEYYRNRNQNNNNQNQQPIEALGNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAG1</accession>
    <name>K9ZAG1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221091.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3329"/>
    <dbReference type="EnsemblBacteria" id="AFZ55373">
        <property type="protein sequence ID" value="AFZ55373"/>
        <property type="gene ID" value="Cyan10605_3329"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3329"/>
    <dbReference type="eggNOG" id="COG4103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152374_0_0_3"/>
    <dbReference type="OMA" id="QPEERQY"/>
    <dbReference type="OrthoDB" id="1978736at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="137" mass="15615" checksum="27338B0268BFB693" modified="2013-03-06" version="1">MSKENKTKLLIKILVGAAWIDGVIQAEEREYLKKVVTENHLENDPEIKSLLSEIKPINAQECYQWLEDYLGNSPKTEDYQKLLEAISALVYSDGDIDIQEAKLLSRLQDLEPNGDNKSIPKQILQSIKKIYQKAIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAY6</accession>
    <name>K9ZAY6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3515"/>
    <dbReference type="EnsemblBacteria" id="AFZ55548">
        <property type="protein sequence ID" value="AFZ55548"/>
        <property type="gene ID" value="Cyan10605_3515"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3515"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_18_2_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="11133" checksum="6EFE89F5B658523E" modified="2013-03-06" version="1">MTNDGLQILYNRYYKDNLERQLELEKMRLDDQVSREITKVKKLYNLSNQDLAKLINTDPLTIDSLENGDYEGDSFLMLSLIANALKMAVRFELVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ58</accession>
    <name>K9YZ58_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217916.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0023"/>
    <dbReference type="EnsemblBacteria" id="AFZ52184">
        <property type="protein sequence ID" value="AFZ52184"/>
        <property type="gene ID" value="Cyan10605_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0023"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.24"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_3"/>
    <dbReference type="OMA" id="MANGQCF"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="391" mass="44369" checksum="418E5427B2A27894" modified="2013-03-06" version="1" precursor="true">MTIIIAILSFKLLLFQGVCTFILLSRLARGARRIPPLTPKLPYLALIGKVSVIIPTLNECDRISPLLESITRQSYETREIIFVDSNSTDGTQEKIENYSKKDPRIHLITDPPLPKNWVGRPWALHNGFLNSSENSEWILGVDADTIPHKNLVATVLDFAIQQDYDLVSFSPQFILKSMGEWWLQPSLLMTLLFRFESSGVNTNNPSTIMANGQCFLIKRNILTEINGYTYAANSFCDDVTLARYVASLGYKVGFADGSKIIKVRMYEGLQDTWQGWGRSLDLKDASSKLQLWGECLFLLLIQALPLPLFFLCLFFYPHFDFLSFKLLFALNTFLVIIRFALLGAIASSYQFNKSISELTFILSPFADILAVTRIILSAFTKPSQWRGRVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZD9</accession>
    <name>K9YZD9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="4" type="synonym">rpl33</name>
        <name evidence="5" type="ordered locus">Cyan10605_0154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218043.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0154"/>
    <dbReference type="EnsemblBacteria" id="AFZ52311">
        <property type="protein sequence ID" value="AFZ52311"/>
        <property type="gene ID" value="Cyan10605_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0154"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.160"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_3_0_3"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="64" mass="7510" checksum="1607A8177A2A90C6" modified="2013-03-06" version="1">MASKKGVRIIITLECTECRTNPDKRSKGVSRYTTMKNRRNTTGRMEIKKFCTHCNKHTIHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z003</accession>
    <name>K9Z003_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxyneurosporene-O-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0353"/>
    <dbReference type="EnsemblBacteria" id="AFZ52499">
        <property type="protein sequence ID" value="AFZ52499"/>
        <property type="gene ID" value="Cyan10605_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0353"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.370"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_12_0_3"/>
    <dbReference type="OMA" id="EYMEGFL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="39735" checksum="9EC8F9BF6B6BF88F" modified="2013-03-06" version="1">MIYNQDKPRKNIVKLMNNHLLPPHIQLTQMISGYWLSQSIYVISKLGIPDLLQNSPQTCEKMASLKNINSSALYRVMRALASVGIFSEVESQRFSLTPLGEYLCENHPQSVKATAIMLGEAPHYQAWGNLFHSVKTGKPAFDDVFGMGVFEYFKSHPEDAEIFENSMSSFSFSEERAILEAYDFSDFTTIVDVGGGYGEMLGSILEKYPQCQGILFDEEYVISHCQETLKKHNINNRCQAISGSFFEKIPSGGDAYLLKHIIHDWGDESAIAILQNCREVLPEHGKILVMEMIVPQGDTPSSAKMLDLNMLVMCPGGKERSKIEFEELFSLAGLTLHRIVTTSEEVCILEATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z048</accession>
    <name>K9Z048_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0437"/>
    <dbReference type="EnsemblBacteria" id="AFZ52581">
        <property type="protein sequence ID" value="AFZ52581"/>
        <property type="gene ID" value="Cyan10605_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0437"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.462"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_3"/>
    <dbReference type="OMA" id="WLAYPFM"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="33714" checksum="90B342E9B5B16572" modified="2013-03-06" version="1" precursor="true">MNNQTKKINLITQLNWKPWLFLTPALTLLTIFLFIPILMVFYLSFTDGNIIQISWIGLKNYRKLLIDPDFSQIIFNTIYFSIFTIIPSLIIPLFLAILLNQNLPLKGFFRTAYFLPSITSLVAMGLGFRWLFQNNGTINQILLKLNFYPINWLNSTFWAMPVLILFSTWRQIGFNLVVFLAGLQIIPQNRYEAAELDGANFWAKIWYITLPALKPTLIFATITTTIFTLKSFEQVYIMTGGGPSNSTNILAFYIYELAFRQFNFGYASATTTILLLVALILVSLQLFTTKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P4</accession>
    <name>K9Z0P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218029.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0140"/>
    <dbReference type="EnsemblBacteria" id="AFZ52297">
        <property type="protein sequence ID" value="AFZ52297"/>
        <property type="gene ID" value="Cyan10605_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0140"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.144"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026366_0_0_3"/>
    <dbReference type="OMA" id="HGFHGFF"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="316"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="639" mass="71964" checksum="D4CF6C3AC5E646D3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R4</accession>
    <name>K9Z0R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218049.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0160"/>
    <dbReference type="EnsemblBacteria" id="AFZ52317">
        <property type="protein sequence ID" value="AFZ52317"/>
        <property type="gene ID" value="Cyan10605_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0160"/>
    <dbReference type="eggNOG" id="ENOG502ZCW3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085967_0_0_3"/>
    <dbReference type="OrthoDB" id="1579412at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="29691" checksum="D56451038A96C397" modified="2013-03-06" version="1">MEIFTTILTIIVSSLSFGGLFVNNSLTKVIEKNSEEVRQIDVRVNSVPTHQLLKGKADSIQISLKEWQPRENISLELVEIETDEINLNLSYLRNLKKIEQNEWKKILNSPLNLAGRIIINQDDLNNILTSSQAKSIMAKLAEESDVQIMDLKLDLQTNNRIRIDTKAKLPIRKEELLNINLEFTLDLIKGHKLRITDVKGTLNNRQLSSKLLQGFADNINTQLTLQKLEKYGVIARLLKFKIEDNKLEIAGFVHLDNQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S8</accession>
    <name>K9Z0S8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218532.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0663"/>
    <dbReference type="EnsemblBacteria" id="AFZ52801">
        <property type="protein sequence ID" value="AFZ52801"/>
        <property type="gene ID" value="Cyan10605_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0663"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.699"/>
    <dbReference type="eggNOG" id="ENOG502ZA9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751553_0_0_3"/>
    <dbReference type="OMA" id="FTSHTHQ"/>
    <dbReference type="OrthoDB" id="819226at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="44643" checksum="0AA3BC64C3D6F7AE" modified="2013-03-06" version="1">MFNNIFAIGKEKKNDSQVSQNTDDSIQENEELKPVKSKGLSIQKQREEQIKRKKIIIKYFGKSLLNLQLETGIWTPVYIVDLYEVDFSQNQEDYAPLIDNALNECFEIHKQKLRQKIYRESFNLQPGELLIVAKEIEGEIFLSCKKFPYNIEKLIELLNCGFFTSHTHQLFFLRYFVPPIPDDLYKFDRISIPSKFELVIRKIIHYCDRTFTTDNLPYKKWENLINNLHVLGMIIKFPDREETVTIDALFTEDYSNIGYHRLKVEEIVKDTIDKNPIVIPLFILLLAFFCSDKHDSKIFSYHYLFSPTGITKKKSMERGQLSFFKLFNELLDESLLPNQFRKCMSTIYYEAFILHQYEIEDLLFKYREKYKQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0V4</accession>
    <name>K9Z0V4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="13">ASA dehydrogenase</shortName>
            <shortName evidence="13">ASADH</shortName>
            <ecNumber evidence="7 13">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">asd</name>
        <name evidence="15" type="ordered locus">Cyan10605_0019</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217912.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0019"/>
    <dbReference type="EnsemblBacteria" id="AFZ52180">
        <property type="protein sequence ID" value="AFZ52180"/>
        <property type="gene ID" value="Cyan10605_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0019"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.20"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_3"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="336" mass="36798" checksum="D576A135EE7EFDF6" modified="2013-03-06" version="1">MSNQVRVAILGATGAVGTELINLLIERKFPLKDLKLLASPRSAGKKVTFQDQTLEIEAVDDNSFDDVDIVLASAGGSTSKQWAEKIVAAGAVMIDNSSAFRMNPDVPLVVPEINPNDVHNHKGIIANPNCTTILMGVAIYPLHQIQPIKRVVVSTYQSASGAGARAMEEVKTQSEAILKGENPQPEILPYPLAFNLFPHNSPLMDNGYCEEEMKMVNETRKIFGDDDIRITATCVRVPVLRAHSEAVNIEFAQPFPLNKARDIIAQAPGVKLVEDWQNNYFPMPMDATGKDEVLVGRIRQDLSNPNSIELWLCGDQIRKGAALNAVQIAELLVHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
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                <person name="Wu D."/>
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                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
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                <person name="Eisen J.A."/>
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            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52245.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
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    </evidence>
    <sequence length="646" mass="74145" checksum="F3138A13EA5F6F32" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z116</accession>
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        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
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        <name evidence="8" type="primary">topA</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218159.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0277"/>
    <dbReference type="EnsemblBacteria" id="AFZ52427">
        <property type="protein sequence ID" value="AFZ52427"/>
        <property type="gene ID" value="Cyan10605_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0277"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.287"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_2_0_3"/>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="844"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="874" mass="98084" checksum="CB542861F320F6F7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z135</accession>
    <name>K9Z135_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">Cyan10605_0111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218002.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0111"/>
    <dbReference type="EnsemblBacteria" id="AFZ52270">
        <property type="protein sequence ID" value="AFZ52270"/>
        <property type="gene ID" value="Cyan10605_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0111"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.114"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_3"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="26547" checksum="4D07650C2A58F580" modified="2013-03-06" version="1">MRQIIIAGNWKMHKTQTESLEFLQGFLSHLEDTPEERETVLCVPFTCLNFMSKNLHGSRVKLGAQNIHWADQGAFTGEISGEMLKEFGINYVIVGHSERRQYFGETDETVNARLLAAQKHGLTPILCVGESKAQRDAGETEAVISAQIEKDLVNVDQNNLVIAYEPIWAIGTGDTCEAAEANRVIGLIRSQLTNKNVTIQYGGSVNPKNVDEIMAQPEIDGALVGGASLDPESFARLVNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J6</accession>
    <name>K9Z1J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218812.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0951"/>
    <dbReference type="EnsemblBacteria" id="AFZ53081">
        <property type="protein sequence ID" value="AFZ53081"/>
        <property type="gene ID" value="Cyan10605_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0951"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1004"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057834_0_0_3"/>
    <dbReference type="OMA" id="SFGLHPY"/>
    <dbReference type="OrthoDB" id="710313at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="33529" checksum="6A47C7747D4FE75D" modified="2013-03-06" version="1">MFNIAVKQEEYLIYILKDIENDSRLEIVPEKGGIVTNWKIQGQNILYLDQERFKNPSLSVRGGIPVLFPICGNLPENIFYFEDKKYILKQHGFARDLPWKVIGQSHSKSAKIILSLKSNQETLEVYPFEFELIFSYELLGKKLIIEQSYENKSNKKMPFSTGFHPYFYCGNKDKLKLNIPATEYQNKTGDKTFSFDGNLDYNSPEIDIAFTKLQGNKASFTDEKRDLTVKVKYDDFFSTLVFWTLEGKEYICLEPWSSPRNSINTKEQLKYLQPQEIFHTQIEIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L0</accession>
    <name>K9Z1L0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218197.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0317"/>
    <dbReference type="EnsemblBacteria" id="AFZ52465">
        <property type="protein sequence ID" value="AFZ52465"/>
        <property type="gene ID" value="Cyan10605_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0317"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.330"/>
    <dbReference type="eggNOG" id="ENOG5031NB3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134387_0_0_3"/>
    <dbReference type="OMA" id="KKFPCGH"/>
    <dbReference type="OrthoDB" id="1668905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="126" mass="14926" checksum="0131761E7AB81397" modified="2013-03-06" version="1">MSRRKKKFACGHSGYGKVCHRCEQKHSFREQKRREKNAWQETFCNDPIDLSSLPKNVVLKARQIIKHIQNQTCYTNFRGKRLRHDRFIISIPVTRNYRLICRDYGSFVAPEAVVSHEDYNVCKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P7</accession>
    <name>K9Z1P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218815.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0954"/>
    <dbReference type="EnsemblBacteria" id="AFZ53084">
        <property type="protein sequence ID" value="AFZ53084"/>
        <property type="gene ID" value="Cyan10605_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0954"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_3"/>
    <dbReference type="OMA" id="QRDWVWR"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="43"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="35303" checksum="D6D1620C5618677F" modified="2013-03-06" version="1">MKLKDNSDNAQKYGKQRDWFWHGWRIRYSFYPANMSGKNQIPILLLHGFGASLKHWRYNIPVLRQNHSVYAIDLLGFGNSEKAYAEYGIPFWSELVKDFWDNFINQPCIIIGNSIGSLIALNAVANYPKIARGLVMISLPDIYGRREVIPPFLYPILQKIENLVAFPLLIRLIFYLVRQRGIITRSLKLAYVDHKNVNDELIDIIMTPPQDKGAARALIALTRYVNDFNVSAKTLLSQVHIPILLLWGKCDRLIPPIMAEKLAQINPQITLKLLDNLGHCLHDENPDLFHQLFFEWEKLIINLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P8</accession>
    <name>K9Z1P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218862.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1002"/>
    <dbReference type="EnsemblBacteria" id="AFZ53131">
        <property type="protein sequence ID" value="AFZ53131"/>
        <property type="gene ID" value="Cyan10605_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1002"/>
    <dbReference type="eggNOG" id="ENOG502Z7JN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590279_0_0_3"/>
    <dbReference type="OMA" id="ACIEATI"/>
    <dbReference type="OrthoDB" id="600001at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="450" mass="51976" checksum="B1C77EB6B1FF50AF" modified="2013-03-06" version="1">MNNADYYDQCQEILTDATSRLGFPLGDDKICEISSLITEAMGGNYRCFHNFEHLLMFKDQEDPIITIAGLFHDLVYIQVDRKIPFNLTVYLAPLIQERIDGLYIKSRQNKKDKYLEIILKIFGLNIDDNLSNFRGHNEFLSALCTAQILDNSLPLTVIVRIVTIIELTIPFRQLENNISISQQLEKRLSKVNQQFQLGLKNDEIILTIIQGVKLANLDVSGFASTNVKDFINNTWLLLPETNHILNDQYHYLIKDCCIALIKTTKFIQCLFPENIFHFYHDYPSSDAYESLINRSKYNLNIAQYYFAYHIIGLSILQAFISRFTFSLPLSFFFPHKSNSSKNNSSFIDYIIPVNKKNIIPNSVEDIVSNLISAEFQPSFFPYNDLGNFVILIFNYLTLKDSLIFIDKCLLFFEGEICQDDFLNLFPSPLIKIIEDAIAQHLAEVRSHFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S3</accession>
    <name>K9Z1S3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded nucleic acid binding R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218261.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0386"/>
    <dbReference type="EnsemblBacteria" id="AFZ52530">
        <property type="protein sequence ID" value="AFZ52530"/>
        <property type="gene ID" value="Cyan10605_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0386"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.408"/>
    <dbReference type="eggNOG" id="COG3854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022515_2_0_3"/>
    <dbReference type="OMA" id="ILMLGRP"/>
    <dbReference type="OrthoDB" id="452951at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02645">
        <property type="entry name" value="R3H_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034081">
        <property type="entry name" value="R3H_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="518"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="582" mass="65304" checksum="859A4E89A68000BE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S8</accession>
    <name>K9Z1S8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218845.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0984"/>
    <dbReference type="EnsemblBacteria" id="AFZ53114">
        <property type="protein sequence ID" value="AFZ53114"/>
        <property type="gene ID" value="Cyan10605_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0984"/>
    <dbReference type="eggNOG" id="ENOG503353Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097452_0_0_3"/>
    <dbReference type="OMA" id="CPQLIAN"/>
    <dbReference type="OrthoDB" id="1563081at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="20832" checksum="5D4125ABC0687983" modified="2013-03-06" version="1">MSKTKTQEEKNLEDKKLREILILLDQLFRREEATAKGIVGCLYDIATINLINKYCPLWGINATLKYLTRFPRPLAKSLGVKLYLQPKCPQLITDWLYSLVEFPDKQIPAIEPEIIETELLPTIRKNRLEIESLRHKVKLLTGTLVATFILFSSGFAWVSYNLQMNPMELLTTSTFIENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T3</accession>
    <name>K9Z1T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218060.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0171"/>
    <dbReference type="EnsemblBacteria" id="AFZ52328">
        <property type="protein sequence ID" value="AFZ52328"/>
        <property type="gene ID" value="Cyan10605_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0171"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.179"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063207_0_0_3"/>
    <dbReference type="OMA" id="RKEWQKE"/>
    <dbReference type="OrthoDB" id="1879268at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="38171" checksum="E92AF98B11DA20F8" modified="2013-03-06" version="1">MSQAELQPTKVQIMSAFHRLLNQYQQQEAKITTKEEAIEKEKNKVLLTKVADYTVNNIVNSMATLQLDFGNLTKEIATRLENESNILIDLKKAITVEAKRLEELKQIRLVADGLYILRQEHQEKLKLLENQIEESKKLIEIQQEKLRKNWEKEQAEFEIKIAEESKLLEEARAKEEADYNYNLQISRKREMDEYEETKRNQERELNLLGKEKNKLWQERENILASQEEEFKANQEKIAQLEEQIKTEVNKARSEAIQEADREAKVKANLVEKEWEATKQGYEFKIQSLEAKIAQQNQQIDAIALQLQNATNQAQSLALKAFQSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U9</accession>
    <name>K9Z1U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0541"/>
    <dbReference type="EnsemblBacteria" id="AFZ52682">
        <property type="protein sequence ID" value="AFZ52682"/>
        <property type="gene ID" value="Cyan10605_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0541"/>
    <dbReference type="eggNOG" id="ENOG5033KCS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168132_0_0_3"/>
    <dbReference type="OrthoDB" id="2073337at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12031" checksum="7D56675CB4002DF8" modified="2013-03-06" version="1" precursor="true">MKKILVGLLFSALSIGVNSISRVLAIPPTIATIINMNTGDRGCYVELLDMEGNITVELADFSICEQSNLINKKVELLYEKTNILASECQGNIDCKLSDQVMLIIDVKIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y6</accession>
    <name>K9Z1Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-16-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218458.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0588"/>
    <dbReference type="EnsemblBacteria" id="AFZ52727">
        <property type="protein sequence ID" value="AFZ52727"/>
        <property type="gene ID" value="Cyan10605_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0588"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.620"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_3"/>
    <dbReference type="OMA" id="EIPHTPY"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="379"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="733" mass="83108" checksum="B3B1B80D84515950" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z291</accession>
    <name>K9Z291_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218988.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1137"/>
    <dbReference type="EnsemblBacteria" id="AFZ53259">
        <property type="protein sequence ID" value="AFZ53259"/>
        <property type="gene ID" value="Cyan10605_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1137"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001223_0_0_3"/>
    <dbReference type="OMA" id="NNVPVQR"/>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1756" mass="194365" checksum="4E9582F4747988C3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z295</accession>
    <name>K9Z295_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ordered locus">Cyan10605_1142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218993.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1142"/>
    <dbReference type="EnsemblBacteria" id="AFZ53264">
        <property type="protein sequence ID" value="AFZ53264"/>
        <property type="gene ID" value="Cyan10605_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1142"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1209"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_0_3"/>
    <dbReference type="OMA" id="ECKYEHF"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="14010" checksum="A15BAD6CDA8E5108" modified="2013-03-06" version="1">MGLPSKHRLKRRLNFQSVYQQGIRRSSRYFIVRGLRVDESVSVYTQIGISVSRKVSKKAVVRNQIKRHIRVAFRSLLPKISSPWFIVIVVKPEVKECNYEHFLRELEKLLIKANIINGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K6</accession>
    <name>K9Z2K6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218531.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0662"/>
    <dbReference type="EnsemblBacteria" id="AFZ52800">
        <property type="protein sequence ID" value="AFZ52800"/>
        <property type="gene ID" value="Cyan10605_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0662"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.698"/>
    <dbReference type="eggNOG" id="ENOG502ZQCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124487_0_0_3"/>
    <dbReference type="OMA" id="MCDPEWK"/>
    <dbReference type="OrthoDB" id="1627477at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="22401" checksum="3224B4238AF69D9B" modified="2013-03-06" version="1">MSIKQSDYETVLADYSSRKRVVSLLGMYREYLEMIPSMRRPTESVITIPLPLAKVRNLKTVSGDCLSSVGTDEITPIPCDLAILMCDPEWKIKIGVEILVFIHRPQEDFSDLLRRWRQSQIYLNKEYEWIMPKTEEHMFSDLAEEIRPLFVVFSQTPERIKKGLLGANLPYVEYIPEVPSDDPEFIPSTMKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U7</accession>
    <name>K9Z2U7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0772"/>
    <dbReference type="EnsemblBacteria" id="AFZ52905">
        <property type="protein sequence ID" value="AFZ52905"/>
        <property type="gene ID" value="Cyan10605_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0772"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.813"/>
    <dbReference type="eggNOG" id="ENOG5032SW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131568_1_0_3"/>
    <dbReference type="OMA" id="NYLLGAC"/>
    <dbReference type="OrthoDB" id="1893918at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16214" checksum="C5DEBE9B78D5F912" modified="2013-03-06" version="1">MNTVETSPEQEKEQQLIDNSMEEYYQLRNNLLIGTVVIAVVSFILVWVFYSLQTSLSYLLGACVSLVYLNMLAREVERVGVYKKKIGSTRLAIFVGLMVVATQWQQLQVLPVFLGFLTYKAAILLYVIPTSLLGNLQKTEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X4</accession>
    <name>K9Z2X4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0802"/>
    <dbReference type="EnsemblBacteria" id="AFZ52935">
        <property type="protein sequence ID" value="AFZ52935"/>
        <property type="gene ID" value="Cyan10605_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0802"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.844"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_3_2_3"/>
    <dbReference type="OMA" id="LYGTWWG"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="30401" checksum="91F93BDEF173D888" modified="2013-03-06" version="1">MFFQNIRKIFPFIFNIKSRRNQTFKTLFFSTFSLTILINILMNSIAVFLFSGSIILSANPSLAQTSINSGFNPQQWLLNALQWIDSLGVMGAIAFMLIYVIATVAFLPGSILTLGAGVVFGIFWGSIYVFIGATIGATLAFLVGRYIARGWVASKIEGNKKFQAIDEAVGREGLKIVLLTRLSPVFPFNLLNYAYGVTRVTLKDYVIASVGMFPGTIMYVYIGSLAGNLATIGTQSTSVNPVAQWSIRIIGFLATVAVTVYITKIAKKALDKSILDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X9</accession>
    <name>K9Z2X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DSH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219295.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1455"/>
    <dbReference type="EnsemblBacteria" id="AFZ53566">
        <property type="protein sequence ID" value="AFZ53566"/>
        <property type="gene ID" value="Cyan10605_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1455"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1543"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_4_0_3"/>
    <dbReference type="OMA" id="ECHYMND"/>
    <dbReference type="OrthoDB" id="66530at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="324"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="974" mass="110779" checksum="1AF5D9005467E94A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y6</accession>
    <name>K9Z2Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218439.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0567"/>
    <dbReference type="EnsemblBacteria" id="AFZ52708">
        <property type="protein sequence ID" value="AFZ52708"/>
        <property type="gene ID" value="Cyan10605_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0567"/>
    <dbReference type="HOGENOM" id="CLU_134473_0_0_3"/>
    <dbReference type="OMA" id="DVYLQIQ"/>
    <dbReference type="OrthoDB" id="1783734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938646" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="140" mass="15903" checksum="E4A109786D632448" modified="2013-03-06" version="1" precursor="true">MLKIARILICFALYFIMTGCSVNPPPLEFAPDATTIEKAIALQINKKYGVLSTHLGTQKPTIEIEKINIRKIEPSNKFNLPTYHLTGDYLVVTKNNKNKGKKIKNSFTLNLQRQNAGKTWRLLLPDTNSSSDKYFSYQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z331</accession>
    <name>K9Z331_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219343.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1506"/>
    <dbReference type="EnsemblBacteria" id="AFZ53616">
        <property type="protein sequence ID" value="AFZ53616"/>
        <property type="gene ID" value="Cyan10605_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1506"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1597"/>
    <dbReference type="eggNOG" id="COG3044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021720_2_0_3"/>
    <dbReference type="OMA" id="IRDRRMQ"/>
    <dbReference type="OrthoDB" id="269079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="572" mass="63803" checksum="D169F481E6620BD4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z371</accession>
    <name>K9Z371_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2H-phosphodiest domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218766.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0905"/>
    <dbReference type="EnsemblBacteria" id="AFZ53035">
        <property type="protein sequence ID" value="AFZ53035"/>
        <property type="gene ID" value="Cyan10605_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0905"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.951"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118341_0_0_3"/>
    <dbReference type="OMA" id="MDDNYQT"/>
    <dbReference type="OrthoDB" id="1059673at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015069">
        <property type="entry name" value="DUF1868"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08975">
        <property type="entry name" value="2H-phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2H-phosphodiest" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="258" mass="29979" checksum="EC527F08CA546019" modified="2013-03-06" version="1">MDGNYQDYINRVVQMTLPSNYKQQVKNIQSSPKFVDGKAIDFPGFSVITPPEKEETNNKKFYSYLQEIQTQITQELPENLFLPVPPQSFHLTIADLIWDTSYTNAVKENPDFDNLLISEIDKIFKEYAQLNPEIDTLELEVLGLSVFPRAIAVCLAPTEDSYNPIIKLRQLIYQNEQIIKLGIEQQYDFVGHITLGYFDKVEDNIDREQVELVIVKTNEQLVSKNLPTFELSQWELRKFTDMTNFIREQNWASIKVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C2</accession>
    <name>K9Z3C2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA replication and repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219381.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1545"/>
    <dbReference type="EnsemblBacteria" id="AFZ53654">
        <property type="protein sequence ID" value="AFZ53654"/>
        <property type="gene ID" value="Cyan10605_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1545"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1640"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_3"/>
    <dbReference type="OMA" id="AMPDYEL"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="113"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="240" mass="26412" checksum="E11C5231200181E6" modified="2013-03-06" version="1">MVYNLRIADLPLSERPRERLLELGARNLSSAELIAILLGTGQGKGKLSAVGLAQYILNQLGQNKQDPLDVLRTISPTELMEIQGIGPAKATTILAGVELGKRAFQFRPCARAIIDSPNAAAAAFSHELMWQSQERFAVLLLDTKNSLISTQVITIGIATETLIHPRELFREAIRQSATNIIIAHNHPSGNLEPSIEDLNLTKRLLESAKIIGIPILDHLIIGNGDYRSIRQNSCLWEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F5</accession>
    <name>K9Z3F5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1614"/>
    <dbReference type="EnsemblBacteria" id="AFZ53721">
        <property type="protein sequence ID" value="AFZ53721"/>
        <property type="gene ID" value="Cyan10605_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1614"/>
    <dbReference type="HOGENOM" id="CLU_3308337_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="39" mass="4441" checksum="F37FE3009DD5BDCA" modified="2013-03-06" version="1">MPLEYIDMISIIGIITIASIILLPLLAWILTWNDSHLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I1</accession>
    <name>K9Z3I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0805"/>
    <dbReference type="EnsemblBacteria" id="AFZ52938">
        <property type="protein sequence ID" value="AFZ52938"/>
        <property type="gene ID" value="Cyan10605_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0805"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.847"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_0_1_3"/>
    <dbReference type="OMA" id="WIARHAN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="221" mass="25460" checksum="055DF1F6F3876486" modified="2013-03-06" version="1">MNKKELMSSTLYLARHGNRLDFVYPEWFNTAPRKYDPPLSEDGKIQAQQLAQRLIKEKIDYIVSSPFLRAIQTAHIVAENLDLTIKLEAGLGEWHNQDWMSYPPEIHPREELEEIYPRIDWNYSSLLTPIYPESEIEMLTRMKKTGELLVNNFQGNLLLIGHSMTILGITNGLLRENRAIKASVCSLTKIVNREGHWQLELETETSFLSEFDIKLSDGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L4</accession>
    <name>K9Z3L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219061.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1213"/>
    <dbReference type="EnsemblBacteria" id="AFZ53332">
        <property type="protein sequence ID" value="AFZ53332"/>
        <property type="gene ID" value="Cyan10605_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1213"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086346_0_0_3"/>
    <dbReference type="OMA" id="PEYFEVI"/>
    <dbReference type="OrthoDB" id="1482666at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="29487" checksum="9B3F0F06EB594825" modified="2013-03-06" version="1" precursor="true">MRRFWNLATSIIFIIFCISVIGYLQIPITSRKSQAISKEEAIKQEKRDYLTLTFLKNLPNFGFNNLVADWIYLRFVQYFGDESRDLTGYTLNPEYFTAFVDKDPRFIEPYFIFAPATTLFSGRPDVSVDLMSKGLQAIQPQQPKAYQVWYYKGIDELLFTSQPRQAKISYQIAAQWAKYHDNPEAQNLGQLAQDTANFLKENPNSKKAQGASWMSIYTNAREDSVRELALQNIERLGGELRIEGNRATLTFPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L8</accession>
    <name>K9Z3L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219523.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1693"/>
    <dbReference type="EnsemblBacteria" id="AFZ53796">
        <property type="protein sequence ID" value="AFZ53796"/>
        <property type="gene ID" value="Cyan10605_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1693"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1796"/>
    <dbReference type="eggNOG" id="ENOG50316M1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1794121_0_0_3"/>
    <dbReference type="OMA" id="KIAAWSM"/>
    <dbReference type="OrthoDB" id="1806647at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="16353" checksum="36CB469DD7288A0C" modified="2013-03-06" version="1">MNLPSFLWLWKIAAWSMGLSITGYLLLAFSGIYLWKNRTEKKPRPSWLRPFHWITGTILVILILILLSIGLMGTIGYYGSLGHSWHLPAGLTVVTLVLLSAWTSTQIHPSRPWARKLHVNVNIALFFALLAVGLTGLFVVQKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M1</accession>
    <name>K9Z3M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218714.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0851"/>
    <dbReference type="EnsemblBacteria" id="AFZ52983">
        <property type="protein sequence ID" value="AFZ52983"/>
        <property type="gene ID" value="Cyan10605_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0851"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.894"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_3"/>
    <dbReference type="OMA" id="FIHGDMH"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="553" mass="63894" checksum="BF9ECE4734BB7294" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P6</accession>
    <name>K9Z3P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1723"/>
    <dbReference type="EnsemblBacteria" id="AFZ53826">
        <property type="protein sequence ID" value="AFZ53826"/>
        <property type="gene ID" value="Cyan10605_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1723"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1830"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096711_0_0_3"/>
    <dbReference type="OMA" id="NDYLWHE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="268" mass="30127" checksum="490E6FE460534701" modified="2013-03-06" version="1">MLIKIKKDFQEDFFMAKIISIHSYRGGTGKSNLTANIASIVASQGNRVGIVDTDIQSPGVHILFGVNEKKLEYTLNDFLWGQCPIEKVACDVTHVLQENAHKDSKIYLLPSSMKINDISRILREGFDIELLFDGFQSLVDKLKLDYLFIDTHPGLNEETLLSLTFSDIVFVVLRPDKQDFQGTAVTVEVAQKLKVPQIFLIINKALAAYNFMKMSEQIESTYGLPVVGILPESKDVIRLASNGIFSLKYEDHPITETIKEIAKTVMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S3</accession>
    <name>K9Z3S3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218941.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1087"/>
    <dbReference type="EnsemblBacteria" id="AFZ53210">
        <property type="protein sequence ID" value="AFZ53210"/>
        <property type="gene ID" value="Cyan10605_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1087"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097574_0_0_3"/>
    <dbReference type="OMA" id="EYQAVCR"/>
    <dbReference type="OrthoDB" id="1823714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="215" mass="24084" checksum="BBF0225142ACF9BC" modified="2013-03-06" version="1">MIDYIFVCDGEELKALQKSLFSSDLKSKIFPIPIGINPVNNLLKNNRIPREKSILLIGLGGSLSPNYSVGDVVIYESCCYLDDDNLVTKNCDSQLNKYLRDRLNCPLVKGLTTDTLISQSSQKKSLFQKTSASIVDMESFALLNYFQSVSVIRVVSDNYDDDLPDLNSAITFDGKLNNRKVAIAFLKEPWKAVKLIKNALISLRKLSAIVQRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S8</accession>
    <name>K9Z3S8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1754"/>
    <dbReference type="EnsemblBacteria" id="AFZ53856">
        <property type="protein sequence ID" value="AFZ53856"/>
        <property type="gene ID" value="Cyan10605_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1754"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1862"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066336_3_1_3"/>
    <dbReference type="OMA" id="RYQVALM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="21254" checksum="70F6AC4CD35E8AF2" modified="2013-03-06" version="1" precursor="true">MANQELINQVRLSIFNLPSPIVNFISRFFPLIVKAIILLLLAISFILLTPQSVNAQTAVNFTYAQLEGEDFSHRDLTGSVFAASNLRNASFYQSNLTNSVMTEGILFGADLRETNFTGSLIDRVTLDFADLRNAIFTDAIATRTRFYDTNIEGADFTGAVIDRYQVALMCDRASGVNSITGVATRDSLGCDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V0</accession>
    <name>K9Z3V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218789.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0928"/>
    <dbReference type="EnsemblBacteria" id="AFZ53058">
        <property type="protein sequence ID" value="AFZ53058"/>
        <property type="gene ID" value="Cyan10605_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0928"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.975"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_3"/>
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    <dbReference type="OrthoDB" id="1479518at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="37957" checksum="D1A0F7BC3F54F1AC" modified="2013-03-06" version="1">MSRSSSLQYYIIARLLLAPLMLWTIVTIVFLLLRATPGDPTDAILGTRAPEAAKEALREELGLNAPLWVQYFKYLGQVLSFDLGSSLTSRGESVWQVIQQYFPATVELAFFAILVAIAIGMTVGIISSLRPNTIWDLGGRLFGIITYSLPLFWVGMIMQLVFAVQLRWFPLGTRFPIGLDTPNKITGLYTIDSLLSFNGHQFSTSIHYLVLPCFTLGILLSGIFERIVRVNLKKTLQAEYVEAARARGIQERKILFSHAFKNALIPVITVMGLTFAALLGGAVLTEVTFSWPGLGNRLYEAISLRDYPTVQGIMVFFGIIVVFASIIIDIVNALIDPRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z7</accession>
    <name>K9Z3Z7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219196.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1353"/>
    <dbReference type="EnsemblBacteria" id="AFZ53467">
        <property type="protein sequence ID" value="AFZ53467"/>
        <property type="gene ID" value="Cyan10605_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1353"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1427"/>
    <dbReference type="eggNOG" id="ENOG5032RQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093295_2_0_3"/>
    <dbReference type="OMA" id="ACTWHYF"/>
    <dbReference type="OrthoDB" id="1792770at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019634">
        <property type="entry name" value="Uncharacterised_Ycf49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10693">
        <property type="entry name" value="DUF2499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11391" checksum="09C91CCDB2D2F6C8" modified="2013-03-06" version="1">MHSLSIPTWIVHVSSVIEWIAAIWFVWRYGEVSGDRSWYWLAYGMLPALISAMCACTWHLFDNAESWQWLVTIQALTTVIGNITLCIGAWKIWQSSITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z402</accession>
    <name>K9Z402_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219653.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1824"/>
    <dbReference type="EnsemblBacteria" id="AFZ53926">
        <property type="protein sequence ID" value="AFZ53926"/>
        <property type="gene ID" value="Cyan10605_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1824"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1935"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_3"/>
    <dbReference type="OMA" id="WSNIFRK"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="445"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="562" mass="59901" checksum="08C9AB8B9D64A6A2" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z450</accession>
    <name>K9Z450_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_1871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219698.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53971">
        <property type="protein sequence ID" value="AFZ53971"/>
        <property type="gene ID" value="Cyan10605_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1871"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1986"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="GMVKNHC"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="169"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ53971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="45911" checksum="F42953718AC36144" modified="2013-03-06" version="1">MLKVVKVRLYPTNPQKESLAKAFGSCRWLWNHFHALTNETYKQTGKGLSRYDLQKQLPSLKKEYEWLTETYSQCLQVVCLNLSRSFINFFEKRASFPRFKSKHGKQSLSYPQNVKIKGDIIIFPKLGEIYAKIHRSIDGEIKTVTISKNKAEQYYASILFEDGKEQPLPNTEGKAIGLDMGIKDFCVTSDGSKFDNPRWLARHERNLKNKQKDLSRKQKGSNNRNKARIKVAKVHNKISRTREDFHHKLSRRIVNENQVVICENLNIKGMVKNHCLAKSIQQVGWGQFQTMLKYKCEQEGKIYLEIDRFFPSSKTCNHCLNIVDSLPLDIRQWECPRCKTKHDRDMNASCNIRDEGLRILSLGTSESASCPDVRPSKGGRKKATTRLSVGDEAHTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z470</accession>
    <name>K9Z470_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219661.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1832"/>
    <dbReference type="EnsemblBacteria" id="AFZ53934">
        <property type="protein sequence ID" value="AFZ53934"/>
        <property type="gene ID" value="Cyan10605_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1832"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1944"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_0_3_3"/>
    <dbReference type="OMA" id="HQFRHSA"/>
    <dbReference type="OrthoDB" id="1819702at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="270" mass="30313" checksum="7F7B659786A899CD" modified="2013-03-06" version="1">MLELYQFELSQFSEKVRLILDYKGLEYKKVEVTPGIGQLEVYKISGQRQVPVLKDGDTVIADSTEIALYLDRKYPEKPLIPTDGVARGKCLLMEEWADESLGLKGRKAFFHALNHYPSFRSSFLPENTPDILKTFVNAFPSEIMDVFSLGVGFGKDVLKEAEKGLKQDLEALTLILHDQPYLTGDKPTLADLTVAALTTIIKFPSVAYYDLDINLEGKGIPGLADNSAYEPFFTWRDRIYADFRQPVDKSNRNNSSGNSGDSKPTTIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E5</accession>
    <name>K9Z4E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218972.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1121"/>
    <dbReference type="EnsemblBacteria" id="AFZ53243">
        <property type="protein sequence ID" value="AFZ53243"/>
        <property type="gene ID" value="Cyan10605_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1121"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1185"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_4_3"/>
    <dbReference type="OMA" id="IPDMIIC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="24019" checksum="2A125B016803F284" modified="2013-03-06" version="1">MKDSETKKLLLIDDDPNLILLVKDYLEFNGYEVITANHGREAIKILEQDTPDLIICDVMMPEMDGYNFVQEIRQNPSLEWLPVIFLSAKGQSKDRIKGLTQGADVYMVKPFEPDELVAQVKSTLNQTMRLMGSSQKKIDPALRIQVPKSVELTPTETRVVNLVARGLSNKEISQELGVSQRTVESHVSNMLNKTGLHNRTELSRWAIQNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H4</accession>
    <name>K9Z4H4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219811.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1992"/>
    <dbReference type="EnsemblBacteria" id="AFZ54086">
        <property type="protein sequence ID" value="AFZ54086"/>
        <property type="gene ID" value="Cyan10605_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1992"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2114"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075251_0_0_3"/>
    <dbReference type="OMA" id="YFEQGDI"/>
    <dbReference type="OrthoDB" id="1855900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="28504" checksum="CE25CC0503F9233F" modified="2013-03-06" version="1" precursor="true">MEKQQDILGYVGLGISAVGAIASIATANVAYASAGLTVGVGCNVFSRKQQYEGLVNAYNQQQETINELTQKIESNHVELNQTLMDYKADLGTSMERLQHSIQELLNSQKADIAQEIKRLDLQHQELNNVVSNLKEVENLSQELRNNADSADFFYQRGVGYEKLGNITGAIEDYTEAIKRDGNMAKAYHKRGVLYLDSNMKQKAVDDLRKAALLYFEQGDIDSYHQAREMSRNIHDLKMEANGKATEMVVGSELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K0</accession>
    <name>K9Z4K0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219042.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1194"/>
    <dbReference type="EnsemblBacteria" id="AFZ53313">
        <property type="protein sequence ID" value="AFZ53313"/>
        <property type="gene ID" value="Cyan10605_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1194"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1259"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_3"/>
    <dbReference type="OMA" id="FRIPVTF"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="11986" checksum="805EA1B87B6E9ECA" modified="2013-03-06" version="1">MKRFDIYLINLDPTLGSEIQKTRPCVIISPDEMNDYIKTVIVAPMTSKGKLYPTRIRCNFQEKEGLIVLDQIRTVDKIRLVKKLGTLDSSIQDEVLSKLGEMFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M2</accession>
    <name>K9Z4M2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219399.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1563"/>
    <dbReference type="EnsemblBacteria" id="AFZ53672">
        <property type="protein sequence ID" value="AFZ53672"/>
        <property type="gene ID" value="Cyan10605_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1563"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1660"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_3"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="254" mass="27054" checksum="D938D81FAC724258" modified="2013-03-06" version="1">MVKLLPDNLQKLKEQVAIVTGASRGIGKATAIALAEEGAKVVINYANSSQSAEELVKDIIDAGGDAIAVQGDVSQQEQVEAMIKTTTDKWGRIDILVNNAGITRDTLMLRMKLEDWQKVIDLNLTGVFLCCKAVSKIMLKQRSGRIINISSVAGQMGNPGQANYSAAKAGVIGFTKTLAKEFASRGVTVNAVAPGFIETDMTSGLEAEEILKAIPLNRYGKPEEIAGMIRFLAADTASSYITGQVFNVDGGMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P3</accession>
    <name>K9Z4P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiol-disulfide oxidoreductase DCC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219876.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2062"/>
    <dbReference type="EnsemblBacteria" id="AFZ54151">
        <property type="protein sequence ID" value="AFZ54151"/>
        <property type="gene ID" value="Cyan10605_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2062"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127718_0_0_3"/>
    <dbReference type="OMA" id="DGNCNLC"/>
    <dbReference type="OrthoDB" id="2019103at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16552" checksum="17322F964EB2E0AA" modified="2013-03-06" version="1">MSSANYIIIYDGNCNLCVNFTKLLERFDRGKLFRYIPMQNTAILETLNITPQDCEQGMILKKIEDNSLIWQGSEAAEKIIELLPNGQLFINAYRSIPNLKFIGDKSYLKIRDNRYQWFGGREKTYYSPYNLNCKNNSDCLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S8</accession>
    <name>K9Z4S8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219319.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53590">
        <property type="protein sequence ID" value="AFZ53590"/>
        <property type="gene ID" value="Cyan10605_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1479"/>
    <dbReference type="HOGENOM" id="CLU_2878378_0_0_3"/>
    <dbReference type="OMA" id="EGYIWIE"/>
    <dbReference type="OrthoDB" id="2018225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7512" checksum="D01302811F8341CF" modified="2013-03-06" version="1">MYEKIYGVVHVGKNLLIVGYNKKDKWSFRVVTQEGKIVKETTDFLTAESAEKEGYIWIEKNLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W0</accession>
    <name>K9Z4W0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ordered locus">Cyan10605_1510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219347.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1510"/>
    <dbReference type="EnsemblBacteria" id="AFZ53620">
        <property type="protein sequence ID" value="AFZ53620"/>
        <property type="gene ID" value="Cyan10605_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1510"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1603"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_3"/>
    <dbReference type="OMA" id="TDCLYLG"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="8"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="40734" checksum="B59C81E19E8D3A3B" modified="2013-03-06" version="1">MTDRKIALITGVTGQDGSYLSELLLEKGYEVHGIIRRTSTFNTDRIDHIYQDPHQQDARFFLHYGDLTDGTTLRRILEEVKPVEVYNLGAQSHVRVSFDAPEFTVDSVAMGTLRLLEAIKDYRQRTGIDVRYYQAGSSEMFGKVMEIPQKETTPFYPRSPYACGKVYAHWQTVNHRESYNIFACNGILFNHESPRRGETFVTRKITMAIARIVAGQQKKLYLGNLDSKRDWGYAKDYVKAMWLMLQQDEPDDYVVATGETHSVKEFLELAFSHVNLQWEDYVEFDERYLRPAEVDLLIGDPTKAKEKLGWQPSLTFPQLVNLMVDADLEALGISNGDKVQDQAYIRHNMRPSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X1</accession>
    <name>K9Z4X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219192.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1349"/>
    <dbReference type="EnsemblBacteria" id="AFZ53463">
        <property type="protein sequence ID" value="AFZ53463"/>
        <property type="gene ID" value="Cyan10605_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1349"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1423"/>
    <dbReference type="eggNOG" id="ENOG502ZTJ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702263_0_0_3"/>
    <dbReference type="OMA" id="TLFLWQA"/>
    <dbReference type="OrthoDB" id="1614039at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17321" checksum="925466696073D007" modified="2013-03-06" version="1">MNFEIPEAVKTWSQFGHPVMMWVLFAMAIYALYLGIKVKKTRQASKEERKELIKGNFANRHHKVGSIFMALVVLGTVGGMAVTYINNGKLFVGPHLLAGLGMMAMVAVSVSLVPYMQKGNDFARFTHVGLNMSMLLIFGWQAVTGMQIVQKIISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z511</accession>
    <name>K9Z511_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP037205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219986.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2175"/>
    <dbReference type="EnsemblBacteria" id="AFZ54261">
        <property type="protein sequence ID" value="AFZ54261"/>
        <property type="gene ID" value="Cyan10605_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2175"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2311"/>
    <dbReference type="eggNOG" id="COG4338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201808_0_0_3"/>
    <dbReference type="OrthoDB" id="2072536at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017136">
        <property type="entry name" value="UCP037205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37463">
        <property type="entry name" value="PTHR37463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10013">
        <property type="entry name" value="DUF2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037205">
        <property type="entry name" value="UCP037205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="46" mass="5616" checksum="5757B659189B3FEF" modified="2013-03-06" version="1">MAKQRKKSDFPTKICPVCGLSFTWRKKWSKCWDDVKYCSEKCRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z547</accession>
    <name>K9Z547_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Biosynthetic arginine decarboxylase</fullName>
            <shortName evidence="11">ADC</shortName>
            <ecNumber evidence="11">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">speA</name>
        <name evidence="17" type="ordered locus">Cyan10605_1765</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Catalyzes the biosynthesis of agmatine from arginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219594.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1765"/>
    <dbReference type="EnsemblBacteria" id="AFZ53867">
        <property type="protein sequence ID" value="AFZ53867"/>
        <property type="gene ID" value="Cyan10605_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1765"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1873"/>
    <dbReference type="eggNOG" id="COG1166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027243_1_0_3"/>
    <dbReference type="OMA" id="AVEYTQH"/>
    <dbReference type="OrthoDB" id="164471at2"/>
    <dbReference type="UniPathway" id="UPA00186">
        <property type="reaction ID" value="UER00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01417">
        <property type="entry name" value="SpeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040634">
        <property type="entry name" value="Arg_decarb_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041128">
        <property type="entry name" value="Arg_decarbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17810">
        <property type="entry name" value="Arg_decarb_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17944">
        <property type="entry name" value="Arg_decarbox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001336">
        <property type="entry name" value="Arg_decrbxlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01180">
        <property type="entry name" value="ARGDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01273">
        <property type="entry name" value="speA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="14">
        <location>
            <begin position="93"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarb_HB" evidence="15">
        <location>
            <begin position="369"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarbox_C" evidence="16">
        <location>
            <begin position="594"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate-binding" evidence="11">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11 12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001336-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ53867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="648" mass="74019" checksum="3D195D17DED97E14" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z586</accession>
    <name>K9Z586_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219437.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1602"/>
    <dbReference type="EnsemblBacteria" id="AFZ53710">
        <property type="protein sequence ID" value="AFZ53710"/>
        <property type="gene ID" value="Cyan10605_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1602"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1701"/>
    <dbReference type="eggNOG" id="COG4360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_3_0_3"/>
    <dbReference type="OMA" id="GLWFFNS"/>
    <dbReference type="OrthoDB" id="1314021at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="PTHR38420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A_phos_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ATP_transf" evidence="2">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="34514" checksum="4C47EC10298CF9E2" modified="2013-03-06" version="1">MKSIKDNWWQKITLATEKAIQLDALHSIPNHYQIFEDNNIPFIIRVVDNLNRKDKAKKEQNKVQKKDPNFNPFLPYEENLFIGNISDTHLAILNKYNVVDNHCLIITRDFESQNDILNFHDFYALWTLLKQIKGLGFYNCGKLSGASQPHKHLQLIPEIFTNNISNIPINKVLLEKKEFNKKVTLDTFPYEHRIMYFSSEVLTKSVEYIAELTTEYYRQILRDLGIEIKDNQPSKDYNLLITQDWIKVVPRSQEKYESISVNSLGFAGALLVRNQEQLEKIKQDKPLNILAKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z597</accession>
    <name>K9Z597_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ordered locus">Cyan10605_1618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219452.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1618"/>
    <dbReference type="EnsemblBacteria" id="AFZ53725">
        <property type="protein sequence ID" value="AFZ53725"/>
        <property type="gene ID" value="Cyan10605_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1618"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1718"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_3"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="301" mass="33901" checksum="11FA6B28DBE86ABF" modified="2013-03-06" version="1">MTENWWEIRVNYIPELEDSVFWRLQEFGCQGTALMKEEDNWLIKGYVPTISIDTIDLAALALSLKQDFIMAGQEKPPVVTWQLINNEDWASSWKQYWQPMDIGDRFSIYPAWIEPPENCDHKVALRDRIILRLDPGSAFGTGVHATTQLCLESLEMRIDDDEINLNIADIGCGSGILSIGARLLGAKEVTAVDTDPLAVKATKENSLLNQVDNIKVFQGSIEEVKLQGQKFDGIVCNILAEIIKPMIPEMAEIIKPDGWVILSGILVEQSNEIASILEQNGWAIAALWKRDNWCCLNARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A1</accession>
    <name>K9Z5A1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H-quinone oxidoreductase subunit 4L</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(P)H dehydrogenase subunit 4L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NADH-plastoquinone oxidoreductase subunit 4L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1, subunit 4L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndhE</name>
        <name evidence="6" type="ordered locus">Cyan10605_1623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219457.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1623"/>
    <dbReference type="EnsemblBacteria" id="AFZ53730">
        <property type="protein sequence ID" value="AFZ53730"/>
        <property type="gene ID" value="Cyan10605_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1623"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1723"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_1_1_3"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="11556" checksum="AF56F36CDBE394DE" modified="2013-03-06" version="1">MEIQLEYFLLLAAALFCIGIYGLITSRNAVRVLMSIELLLNAVNLNLMGFSNYLDPAEIKGQIFTIFVITIAAAEAAVGLAIILAIYRNRDTIDMERFNLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A2</accession>
    <name>K9Z5A2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220085.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2276"/>
    <dbReference type="EnsemblBacteria" id="AFZ54361">
        <property type="protein sequence ID" value="AFZ54361"/>
        <property type="gene ID" value="Cyan10605_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2276"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2418"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_3"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="31345" checksum="5D131AECBFE5AFA4" modified="2013-03-06" version="1">MPIFINDEQIFSFVFPAGESHVRISPEMIKPITVIEAWLYKAEDIMALLLSVDAIHRFSLGVKIHLTIPYFPYARQDRVCNQGEALSVKVMANLINSLRCDRILVIDPHSDVTPALLDNCQVKTQADIIFDSVLKNILIEDNWALVAPDAGAEKKVLTVAQRLGLRDVFCASKIRDSKTGKITDTTFHDEVKGRKVLIVDDICDGGRTFIELGKLLREKQAETIYLYITHGIFSKGLQALNPYFDHIYCYHSFLPITEENQDFITVISSHDRHSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B0</accession>
    <name>K9Z5B0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220054.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2243"/>
    <dbReference type="EnsemblBacteria" id="AFZ54329">
        <property type="protein sequence ID" value="AFZ54329"/>
        <property type="gene ID" value="Cyan10605_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2243"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2384"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_8_1_3"/>
    <dbReference type="OMA" id="HPRTYWV"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="199" mass="23046" checksum="4B89361D552171BE" modified="2013-03-06" version="1">MKYKYILFYKPYNVLCQFTDDSPHKNQRQTLKDYINIPHIYSVGRLDLDSEGLLLLTNNPRVKHRLCEPSFAHPRTYWAQVENIPTAESLKQLEEGVIIKGKKTKKATASMLKSEPELPPRNPPIRYRQNIPTAWLELTLTEGRNRQVRRMTAAVGYPTLRLIRVKIGITQQLSLTLEGLNVGEYRELTTSEIKILDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C8</accession>
    <name>K9Z5C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219337.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1497"/>
    <dbReference type="EnsemblBacteria" id="AFZ53608">
        <property type="protein sequence ID" value="AFZ53608"/>
        <property type="gene ID" value="Cyan10605_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1497"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_2_0_3"/>
    <dbReference type="OMA" id="WSAVVTY"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="10503" checksum="CDFD02D0B2929858" modified="2013-03-06" version="1">MEFEYDENKSNINKEKHGIDFEEAQLLWLDNNRIEIKANSTNEFRMIIIGKIKEKYWSAIITYRQTKIRIISVRRSRKQEVNFYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G4</accession>
    <name>K9Z5G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multisubunit sodium/proton antiporter, MrpD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219365.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1529"/>
    <dbReference type="EnsemblBacteria" id="AFZ53638">
        <property type="protein sequence ID" value="AFZ53638"/>
        <property type="gene ID" value="Cyan10605_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1529"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1624"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_6_3"/>
    <dbReference type="OMA" id="IWVALRY"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="115"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="478" mass="53010" checksum="090D462A9AF12DCB" modified="2013-03-06" version="1">MDTITLIWLALPFLAGFIIYLLPKCSRILSLAVLSISVLYPFWLLTSGQDLTLQLLDNFGVSLFIDKLSGYFILTNSLVTIAVLFYCWYEERKAFFYTQLMILYGSVNACFIGYDFISFYVAIEVISIAAFLLIVYPRTDKSIWIGLRYLFVSNTAMLFYLIGAILIYKANNSFSFNGLSNSPPEAIALILLGLLAKGGVFVSGLWLPLTHASAETPVSALLSGVVVKAGVYPLIRLALIVDEMDHIVRIVAIATALLGVIYAIFESDVKRMLAFHTVSQLGFVLASPPVAGIYALFHGLVKSSLFLMAGSLPTRNIKELKHTNINTYLWIALVIASLSISGVPLLAGYCAKVLTVKNLYPWQVMLMNIAAVGTAISFAKFIFLPHDTSAKILKQNWGFWFGVIFLLAGLIFANGFYLSTYTLSNIIKALITVFIGWLVYFVLIKKAVIKLPRILEDFDHLIGIMSLTLVGLFWMVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K3</accession>
    <name>K9Z5K3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220148.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2340"/>
    <dbReference type="EnsemblBacteria" id="AFZ54424">
        <property type="protein sequence ID" value="AFZ54424"/>
        <property type="gene ID" value="Cyan10605_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2340"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2421991_0_0_3"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10151" checksum="BD9CB232890E4648" modified="2013-03-06" version="1">MKTSLNKKLPLKLVLIIPFIVQIVGTVTLVGYLSYRTGRSAVENLANQLMTQTSNRVRDHLNHYLQIKQETIAVNFDILPPLNPTGCNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M9</accession>
    <name>K9Z5M9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219602.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1773"/>
    <dbReference type="EnsemblBacteria" id="AFZ53875">
        <property type="protein sequence ID" value="AFZ53875"/>
        <property type="gene ID" value="Cyan10605_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1773"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1882"/>
    <dbReference type="eggNOG" id="ENOG502ZNY9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099414_0_0_3"/>
    <dbReference type="OMA" id="NFYQDLN"/>
    <dbReference type="OrthoDB" id="1536716at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938627" evidence="1">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="21931" checksum="519237E8346BB511" modified="2013-03-06" version="1" precursor="true">MLSLLSSMRFSQCLGLVVSLTAFQLPSYAQTNINSSLVAQNETVTEEVIIEENTVTPINQTESLLSLEGGQRLMQEAEEAISQENYDLAATKLQQARRIFNQLSNFYLQLAESFAGIDNRITEEQRAGALKTASFRDESTYQLALVHRAQNKPELAVPLLIQIIRSQNPSSELGKKSYQQLYEIGFVQTPIESPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T8</accession>
    <name>K9Z5T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucraseferredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219832.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2013"/>
    <dbReference type="EnsemblBacteria" id="AFZ54107">
        <property type="protein sequence ID" value="AFZ54107"/>
        <property type="gene ID" value="Cyan10605_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2013"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2139"/>
    <dbReference type="eggNOG" id="COG4759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050357_0_0_3"/>
    <dbReference type="OMA" id="CTHGTVD"/>
    <dbReference type="OrthoDB" id="1095432at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38819" checksum="9126CF350C1D6A10" modified="2013-03-06" version="1">MLLESPLTLDECQFCNLVSQNNGEDPLGSAGCYDQWLMMELPQPWEAKFWTSREELKPFVSLMSELISQGKLNKFRLSAIAPDKIYSEKGLTRVIYYYRPGELFTNLEKREYLLPLDKINDLAISLITSSNLDEFETYRKNSDNIREILVCTHGNVDVACSRFGYPIYEKLRKEYSDENLRVWRCSHIGGHRFAPTLIDFPSGRYWGHLNLEILETLINSPEDINKLRPYYRGWSGVSYLEQIFEAKLWQEIGKKWLTYPKTGRVIAQEKVENEEEEEPNWAEIEISYLELETQKVITRKGKLEAKKEILTLAKSGNNELFPVKQYQLNVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V9</accession>
    <name>K9Z5V9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219852.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2038"/>
    <dbReference type="EnsemblBacteria" id="AFZ54127">
        <property type="protein sequence ID" value="AFZ54127"/>
        <property type="gene ID" value="Cyan10605_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2038"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="RCTIARI"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38343" checksum="3649D8B51B6A101E" modified="2013-03-06" version="1">MTIIITPEDNQILWEETLKNTYVDSLDCNDITYPFSSIMGDGYSREIKLTRGLTIEILNCDITQHYLLKNNETARDNIIFHFHLFGYHQDLDTIVNNQEFALYGTGFVPQQINEVPPQKVLEVNIHVDTERLISYIGSKDGELPKPLHNFIKPLTRQSYACVGKVTPMLEGILWQILRCPFQGITKRIYLEAKALELIGLVIAEQIEALSQESCYPKSSIEQCRCTIARIHSAKSILLANLHQPPSIAELARQVQLNEYTLKQGFKEVFKTTIFDYLRNYRLQQAKQLLETGQMGVKEVMNAVGYCDRHHFAMAFRKKFNVNPRDYLKGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X4</accession>
    <name>K9Z5X4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219867.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2053"/>
    <dbReference type="EnsemblBacteria" id="AFZ54142">
        <property type="protein sequence ID" value="AFZ54142"/>
        <property type="gene ID" value="Cyan10605_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2053"/>
    <dbReference type="eggNOG" id="COG4642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032017_4_0_3"/>
    <dbReference type="OMA" id="YRYEGDW"/>
    <dbReference type="OrthoDB" id="1997695at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939131" evidence="1">
        <location>
            <begin position="29"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="37783" checksum="455464B5F8049E84" modified="2013-03-06" version="1" precursor="true">MKAKNLLLISLLSAILNNMTMTSSPVFANTITLPDGGKCEGEVSGGNLNGEAKCTFSNGDRYEGNFVDGEKQGKGKYTFANGGYYEGEFQNSQFEGQGVRVFPEGDKYEGEFKEGKPEGKGVYTSTDGSRYEGNFVNGLPQGEGTFIYSNGDSCTGMVTDGKINGQGICTYENGDRYEGLLVDSQPQGEGIYTFADGGIYQGTFQEGRISGKGERKYADGDSYEGEIKNGIPHGKGIYKFADGGVYEGDFENGKQVGKGIYKFANGNRYDGEFVNGQFEGEGIFTFANGDVCQGTFKNNQLNGDVICDYANGDTYKGEFVNGKKNGRGVYNFADGTVIDGNWKDDQPINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y8</accession>
    <name>K9Z5Y8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_1695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219525.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1695"/>
    <dbReference type="EnsemblBacteria" id="AFZ53798">
        <property type="protein sequence ID" value="AFZ53798"/>
        <property type="gene ID" value="Cyan10605_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1695"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1800"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_1_3"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="338" mass="38006" checksum="153DD414DEFD6576" modified="2013-03-06" version="1">MEIKNTLLKEKLSTPLKIGSVVVNSRVLQSPLSGVTDLVFRRLVRRYAPESMTYTEMVSATEIHHLQQLPRLMEIDPHEQPISIQLFDCRPDFMAEAAQKAVQEGAKTIDINMGCPVNKITKKGGGSRLLRQPEIAEAIVKEVEKAVNVPVTVKTRIGWNDDEINILDFAEKMEIAGAQMITIHGRTREQGYTGKARWDIIAQVKEKLSIPVIANGDIFSVEDAIRCLEITNADGIMCSRGTLGYPFLVGQIDHFFKTGQLLPIPSLSERLECAKEHLMGLWEYKGKRGIYQARKHLTWYCQGFKGAAEFRDQCTRIDTVEEGINLLQNAITQLKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z669</accession>
    <name>K9Z669_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein PatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls heterocyst pattern formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nitrogen starvation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220394.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2596"/>
    <dbReference type="EnsemblBacteria" id="AFZ54671">
        <property type="protein sequence ID" value="AFZ54671"/>
        <property type="gene ID" value="Cyan10605_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2596"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2757"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031371_0_0_3"/>
    <dbReference type="OMA" id="ICQTMEK"/>
    <dbReference type="OrthoDB" id="806256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043158">
        <property type="term" value="P:heterocyst differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024186">
        <property type="entry name" value="Sig_transdc_resp-reg_PatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005897">
        <property type="entry name" value="RR_PatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0364">Heterocyst</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="400" mass="45194" checksum="7AE80ED3A0BBE59F" modified="2013-03-06" version="1">MNSNENASNPIPFKEFTGVKQTGFFENLKQPRFSGQLLLTGPNHSKWVFYLYLGRLVYATGGNHPVRRWRRNLVAHLPNIPSHMAAIQADVDSLDLTGENNCWEYELLCFWVEQQKITLEQAAKMIRQNIVEVLFDVTQAMQVTCQLKPDKNLPFSTRLVLIDAEQLIAEAQKLWQAWQGAKIADRSPDMAPIIAQPQELQQQTNPQIYQTLSQLLDGQQTLRDLSVRMKRDVVTVTRSLLPYIQRGLVRLIEINDIEPPKLPQKNDSDSGILNNQKITVACVDDSPLICQTMEKIITEAGYNFVGINDALRAIAVLLSKKPDIIFLDLIMPNANGYEICSQLRKLTFFKHTPIVILTGNDGIVDRVRAKMVGSSDFLGKPIDPTLVLETIRKHLKIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H7</accession>
    <name>K9Z6H7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="8">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220514.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2719"/>
    <dbReference type="EnsemblBacteria" id="AFZ54791">
        <property type="protein sequence ID" value="AFZ54791"/>
        <property type="gene ID" value="Cyan10605_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2719"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2884"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_3"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="9">
        <location>
            <begin position="41"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="42630" checksum="6189D2AC3AB8ABBD" modified="2013-03-06" version="1">MSSLNNYLSQSLNTIKKAHWYRQEKLITGLPSAVVSIEGRQLVNFASNDYLGLAGDSRLIQAGIEALKQYGTGSTGSRLLSGHRKLHQELEDAIASWKQVEKALVFSSGYSANIGTITSLVKQKDLILEDEYNHSSLKNGAKLSQAKKIQYKHGNIQDLSEKLAQNRHQYRHCLIVTDSVFSMDGDLCPLPELVAITEKFDCWLLIDEAHATGVMGKTGAGCLEHFGVKGDNIIQIGTLSKAIASLGGYVAGSKLLIDFLRNRCPTWIYTTALSPADTASALAAIKLIQKYPEMRTRLWQNINLFKEILTTLKIDFLPTESAIICVKEKTAKQALQWSLKLQEKGFFVPAIRPPTVPTSRLRFSIMATHEKRHFYDLQSYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K5</accession>
    <name>K9Z6K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220487.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2691"/>
    <dbReference type="EnsemblBacteria" id="AFZ54764">
        <property type="protein sequence ID" value="AFZ54764"/>
        <property type="gene ID" value="Cyan10605_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2691"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2855"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_15_1_3"/>
    <dbReference type="OMA" id="MRFCYGA"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="456" mass="49630" checksum="4E1AA8E2B3FC72DB" modified="2013-03-06" version="1">MPVFETDTEEKSEPVSANSSLANPSPTHHKANNGIMSVLRNISFLILWLGQIFSQLADKIYLVLMIALISANFQTQGESISSWVSLIMIAFTIPAILFGSLAGVYVDRWSKKSVLVVSNLGRGILVLILPFCLLINKQEMGFFSLPWSFWLLLLVTFSVSTLTQFFAPAEQATIPLIVRKKDLLAANSLYTTTMMAMLIIGFAVGEPLLEITYNWGENFSFAYGKELLVGGCYLLAGIVLMTMRSREKDKDRQQQENHPWEDIKDGLRYLQKNHRVRNALFQLVILFSIFAALAVLAVRLAETIPGMEADQFGYLLAATGIGIAIGAVFVTHQGKMIPHARLSFWGSMGMGAALSGLSVATNNLILALLMTVILGIFAALVGVPMQTTIQAETPSDMRGKVFGLQNNAVNIALSLPLALAGIAETYFGLRIVLMILASLAVSGMALTSLITGKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z709</accession>
    <name>K9Z709_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220700.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2919"/>
    <dbReference type="EnsemblBacteria" id="AFZ54981">
        <property type="protein sequence ID" value="AFZ54981"/>
        <property type="gene ID" value="Cyan10605_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2919"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3106"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_3"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="33423" checksum="0CD16EDCBD029359" modified="2013-03-06" version="1">MKVANNITELIGRTPLVRLNRIPQTEGCVGEILIKLEGMNPSASVKDRIGVNMINEAEKQGLIQPGKTTLVEPTSGNTGVALAMAAAAKGYKLILTMPETMSEERRAMLRAYGAKLELTPGVEGMAGCIERAQEIAETLPNAYMLQQFQNPANPAIHRQTTAEEIWEDTDGKIDFLVAGVGTGGTITGVSEVIKQKKPDFKTIAIEPVNSPVLSGGKPGPHKIQGIGAGFIPEVLKVDLIDEIITVSDEDAIAFGQRLAKEEGILSGISTGAALAGAIKLAQRKENEGKLIVMIQPSFGERYLSTPLFQNLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z728</accession>
    <name>K9Z728_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220671.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2883"/>
    <dbReference type="EnsemblBacteria" id="AFZ54949">
        <property type="protein sequence ID" value="AFZ54949"/>
        <property type="gene ID" value="Cyan10605_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2883"/>
    <dbReference type="HOGENOM" id="CLU_2080880_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13888" checksum="416EF5E86786EDE0" modified="2013-03-06" version="1">MLKEIKEECLKENINISKYPITLDSWDVSKQLKEQLDELGFTKIIMAGKSSYVFEEEDFKGKGGEWKKRVDYQENQWGIDVPCVRKKLSNPTFGELNLWFFYSGYDKLTENNFHNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z754</accession>
    <name>K9Z754_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220750.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2969"/>
    <dbReference type="EnsemblBacteria" id="AFZ55031">
        <property type="protein sequence ID" value="AFZ55031"/>
        <property type="gene ID" value="Cyan10605_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2969"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3160"/>
    <dbReference type="eggNOG" id="COG3779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028584_0_0_3"/>
    <dbReference type="OMA" id="MLWRWYD"/>
    <dbReference type="OrthoDB" id="883629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="511" mass="59795" checksum="B21FFA0F2EB02A05" modified="2013-03-06" version="1">MNNKKVDKPYKKPVILSWFCEWYLDRIFISRIMAIISALNLLVVAFDITYIPLRDIWLNGKITLGKFKIGPYEYEGLPLTVLPQKWSQKITQYDVIKGIEPNRDTQTYLKEVSLLEDSINQYGLNSPETEEILTKLREYSEDMIEQNPFAVASKSGTLEVIKNRMRDHMNKYIDNPEDSAKLAFDSFWNTQHLQKQFPKELNFFNEQIKPLIKTNYYRPIGENGDFVDYFGLIDFPFIAILFADFIIRCLGISIRYHGVNFKDAIFWRWYDLIFFLPKYRWLRIIPVTIRLDEAKLLDSKRIKKQASQGFVAGIAGDITEVVILRIVNQIQSDIKKGQIEKMLIPKGKVREYVDLNDINEIAEITKLVIDLVVKELLPEIRSEVEILLAYTIEKTIIDSPIYPNIKSLPNFNKVSQNLSQRLANRIYQVFLETINNFIKEDPIFDQYLEKIIAKFGNTLTDRPNAKYDINKIEQLLVALLEEIKVNYIQNLSDQDIEALLDETRALRSFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z762</accession>
    <name>K9Z762_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220134.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2326"/>
    <dbReference type="EnsemblBacteria" id="AFZ54410">
        <property type="protein sequence ID" value="AFZ54410"/>
        <property type="gene ID" value="Cyan10605_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2326"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="LAEVWDW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26769" checksum="A20F6D8DACFEC2D1" modified="2013-03-06" version="1">MEILIVEDEREIAQLINSCLSREGFTCHHAYDGVTALQQAQTIQPDLIILDLMLPQLDGLEVCTRIRNQGMTKDPYILMLTAKGEELDRIIGLSTGADDYLVKPFSPRELVARVRALLRRSLRHEKQSQIYETPHFILNLDEHIATRKLENQPPEELDLTALEFNLLSAFISYPGKVWSREQLIDKLWGADFFGDERVVDTHIRRLRKKIEPNPAQPSFIKTVVGVGYKFEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A9</accession>
    <name>K9Z7A9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220350.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2547"/>
    <dbReference type="EnsemblBacteria" id="AFZ54627">
        <property type="protein sequence ID" value="AFZ54627"/>
        <property type="gene ID" value="Cyan10605_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2547"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2702"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011907_3_0_3"/>
    <dbReference type="OMA" id="QRLCYAN"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003919">
        <property type="entry name" value="Cell_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01439">
        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="183"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="754" mass="85950" checksum="C356ABFABE886919" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H2</accession>
    <name>K9Z7H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220058.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2247"/>
    <dbReference type="EnsemblBacteria" id="AFZ54333">
        <property type="protein sequence ID" value="AFZ54333"/>
        <property type="gene ID" value="Cyan10605_2247"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2247"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2388"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831304_0_0_3"/>
    <dbReference type="OMA" id="IHRDFYP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="108"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="358" mass="42495" checksum="83F78D26D0A2EFBA" modified="2013-03-06" version="1">MNCTIINNYQIHPKDKLINHIKNAINPHQVIKIFSENISILQEDNYKLIKIELIRYKPQKRCLIEYHFQGKNNLILIGKIRAKKTDFHSFQLQKNLWQNGFDENSQDNISVPEVVGIVTQWQMWLQKKVSGQILSQYLTKNQPIKIYQKVAYIAHKLHKTNIPTNRNHIITNELNILYEKLPLLKKYYPHWQKRIENLLNQCDILASKVIETELCGIHRDFYFDQIIIDNNCFYLLDLDLYCRGNPCLDIGNFIGHISEYSLRQFEDISALKYQELALKNEFINIHKREKQDHLSLSELKDLKTIINNNIDIYSLLTLVRHIYLSTQFIERHTYTKKLFDFCEEKIKLALTFSLSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z822</accession>
    <name>K9Z822_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220604.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2815"/>
    <dbReference type="EnsemblBacteria" id="AFZ54882">
        <property type="protein sequence ID" value="AFZ54882"/>
        <property type="gene ID" value="Cyan10605_2815"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2815"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2992"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11704" checksum="86FA2695972D2EDE" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSQFPKTEIDGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLKEQELKVTALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z825</accession>
    <name>K9Z825_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221064.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3301"/>
    <dbReference type="EnsemblBacteria" id="AFZ55346">
        <property type="protein sequence ID" value="AFZ55346"/>
        <property type="gene ID" value="Cyan10605_3301"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3301"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3515"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064833_2_0_3"/>
    <dbReference type="OMA" id="DNTKWLP"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044241">
        <property type="entry name" value="TxlA/HCF164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353">
        <property type="entry name" value="PTHR47353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20060" checksum="5D6C446440F83AD7" modified="2013-03-06" version="1" precursor="true">MTDSPNTVNKIRNLVIALVAIALAITLVFASQTKVSSQSLEAQAQKATNLDIALNNGKPSLVEFYANWCTSCQAMAGDLAQLKENFEDKINFVMLNVDNSKWLPEILNYGVDGIPHFVFFNENGDAIADTIGEQPLTIFEENLQALLNHQPLPYANSRGNISAFNPANKLQTGNQDNPRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z890</accession>
    <name>K9Z890_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2881"/>
    <dbReference type="EnsemblBacteria" id="AFZ54947">
        <property type="protein sequence ID" value="AFZ54947"/>
        <property type="gene ID" value="Cyan10605_2881"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2881"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4997">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045511_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11532">
        <property type="entry name" value="NTP-PPase_COG4997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038735">
        <property type="entry name" value="MSMEG_1276-like_NTP-PPase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="54533" checksum="A7EC559A0B7630D4" modified="2013-03-06" version="1">MSKYSKLIRDNIPDLLDKNNLSYQVKILNHDQYKQGLKWKLIEEAGEVFTTDNKEDLIEEIADVYEVIEAILEANNITSDYVNLVKEKKAKLKGKFRKKLQLLNLINSEEKKDLNLSIKELETIDKAEVFLQKKVLPQANILDKDSQLLKTHFYDFNRIDSSFLRLKIDTKWQGLAMSNLGFYSWQIMIAKYSGAFAFLQTQHQSAIAFLNSSDNEILKEKYLTQIGKENYFYGVGFSHLRRKEKPLVSATVREKGYELNGFIPWITGYDIFSHFIIGATLPDGQELYGIIPFQNQNSYLELSQPLQLCAMTSTNTVTGKLNNYLLRKEDIVTIKPRNNIHLKDQENILHHGFFPLGCTFASLRIIEENLVKLDYQEIKETYFELKNQVENLQEKMLTAMVDKNVSFAEKLKLRVEAINLAHKSAIASIITSKGTANIDSHPANRVYREALVYSVSGQTLPLLKDSCYSLIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C1</accession>
    <name>K9Z8C1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cl-channel voltage-gated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2915"/>
    <dbReference type="EnsemblBacteria" id="AFZ54977">
        <property type="protein sequence ID" value="AFZ54977"/>
        <property type="gene ID" value="Cyan10605_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2915"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3102"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016449_0_0_3"/>
    <dbReference type="OMA" id="IVIVFEM"/>
    <dbReference type="OrthoDB" id="62196at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="466"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="527"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="882" mass="95938" checksum="1920B2C0A537B1F9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C2</accession>
    <name>K9Z8C2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221117.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3357"/>
    <dbReference type="EnsemblBacteria" id="AFZ55399">
        <property type="protein sequence ID" value="AFZ55399"/>
        <property type="gene ID" value="Cyan10605_3357"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3357"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3575"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_4_0_3"/>
    <dbReference type="OMA" id="WVDYTEL"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16364" checksum="D8521CDAC9FEE977" modified="2013-03-06" version="1">MLDQGDRESKTGFEPELGGIWRDNPDRSGFEPELGGIDREKGVYVDEVTCIGCKNCVHVAPNTFYIENDYGRSRVYNQDGDTEEIVQEAIDTCPVDCIHWLDYTEIRKKEEERKYQEIRPLGYPQVNKSGKNTKKNKSKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E5</accession>
    <name>K9Z8E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221184.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3426"/>
    <dbReference type="EnsemblBacteria" id="AFZ55466">
        <property type="protein sequence ID" value="AFZ55466"/>
        <property type="gene ID" value="Cyan10605_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3426"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3651"/>
    <dbReference type="eggNOG" id="ENOG502Z7UM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526628_0_0_3"/>
    <dbReference type="OMA" id="IWGHRLY"/>
    <dbReference type="OrthoDB" id="791549at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="569" mass="66393" checksum="C3EC38B4208ED4D7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H1</accession>
    <name>K9Z8H1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ordered locus">Cyan10605_3454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221209.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3454"/>
    <dbReference type="EnsemblBacteria" id="AFZ55491">
        <property type="protein sequence ID" value="AFZ55491"/>
        <property type="gene ID" value="Cyan10605_3454"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3454"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3678"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_1_1_3"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="100"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="38249" checksum="046F8E20680BCAE1" modified="2013-03-06" version="1">MAIKEKEVLLGKSLSELTTWVENQGQPAYRGKQLYQWLYEKGATSLMDITVFPKQWRENQAENIIGRSQVHYCSTASDRTCKYLLKLADGLIIETVGIPTDKRLTVCVSSQVGCIMACDFCATGKGGFTRNLYAHEIIDQILTVQNDFGERVSNVVFMGMGEPLLNLPQVVKAIKSINEDVGIGARSLTISTVGLPNKILELAQHKLQITFAVSLHASNQAVREKLIPSANHYPLEQLLADCREYVKMTGRRVTFEYILLSGVNDLPQHAQELAQHLHGFQTHVNLIPYNPISEADYQRPSPERVSQFKKLLQQEKIAVSVRYSRGLDADAACGQLRASKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J4</accession>
    <name>K9Z8J4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome c-553</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cytochrome c553</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Soluble cytochrome f</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">petJ</name>
        <name evidence="9" type="ordered locus">Cyan10605_2843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cellular thylakoid lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Binds 1 heme c group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c family. PetJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220632.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2843"/>
    <dbReference type="EnsemblBacteria" id="AFZ54910">
        <property type="protein sequence ID" value="AFZ54910"/>
        <property type="gene ID" value="Cyan10605_2843"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2843"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3021"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_1_0_3"/>
    <dbReference type="OMA" id="GQNVIMP"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031979">
        <property type="term" value="C:plasma membrane-derived thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00594">
        <property type="entry name" value="Cytc_PetJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023655">
        <property type="entry name" value="Cyt_C6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34688">
        <property type="entry name" value="PTHR34688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009016574" description="Cytochrome c6" evidence="6">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="12016" checksum="FC9AFA2FD05479A3" modified="2013-03-06" version="1" precursor="true">MKKLLGLILLLITAVNFFFATPALAGDVTKGAAIFSANCASCHMGGKNVVNPAKTLQKEDLEKYGMYDIEQIKTQVMNGKAAMPSFLSRLTDEDIDNVASYVLAQADNGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K5</accession>
    <name>K9Z8K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221249.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3497"/>
    <dbReference type="EnsemblBacteria" id="AFZ55531">
        <property type="protein sequence ID" value="AFZ55531"/>
        <property type="gene ID" value="Cyan10605_3497"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3497"/>
    <dbReference type="eggNOG" id="COG5321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771013_0_0_3"/>
    <dbReference type="OMA" id="YLNFCHY"/>
    <dbReference type="OrthoDB" id="1539191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009394">
        <property type="entry name" value="MmcB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06319">
        <property type="entry name" value="MmcB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="42015" checksum="E1013A0F15CB9DB6" modified="2013-03-06" version="1">MLDIDKLEKAEHQIEQLLITPESSWREVAKIAIVVRQKELFKQSGQTSFTAWVHHIAKKCDRQPSLIWRYIKAGKYYLYTVGSKEIEEIDHAVASPEALENLEKVERNAPAPVYEKLKQQVLEGNITVKETRAIEQQYRPLNAKTNRGRPTKGNEGKYEHLGLIGEKTIDNETKQISTQQIAPSIVRSLKINLVDWTKKCSQMRYPPKHYQDHTEVRINFEGKRLRIDFMTVIRWSYKRPKDVFIVEIKSSQQDFISDHKWHKYLNFCHYFCFAIPSQNLSLIKMIEETTNSEVGILLIDLMAEVNEHLSYPVEIYRYPKKLTPSSVSFIYETLYERVLNWSGSDEQDICINDENDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P5</accession>
    <name>K9Z8P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221252.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3501"/>
    <dbReference type="EnsemblBacteria" id="AFZ55534">
        <property type="protein sequence ID" value="AFZ55534"/>
        <property type="gene ID" value="Cyan10605_3501"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3501"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076038_0_1_3"/>
    <dbReference type="OMA" id="CRCLDTA"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938636" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="22614" checksum="EBC103075292F244" modified="2013-03-06" version="1">MTQRRKFLRLLAVSFIAIACGNQYPVVSQQNLSDDYLWSKLQEKGKVYVVLFRHAFAPGTGDPPNFSLNDCSTQRNLSSEGKAQAIRMGEAFKSRQINVTKILSSQWCRCLDTANLMNVGKVQSFPPLNSFFSTPSRLEEQTNQLRKFLLEETHQDGVIVLVSHQVNITAISDIFPRSGEGVVLHIDSNNNQIKVLGRIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S0</accession>
    <name>K9Z8S0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Photosystem I assembly protein Ycf4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycf4</name>
        <name evidence="10" type="ordered locus">Cyan10605_2679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Seems to be required for the assembly of the photosystem I complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the Ycf4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220476.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2679"/>
    <dbReference type="EnsemblBacteria" id="AFZ54753">
        <property type="protein sequence ID" value="AFZ54753"/>
        <property type="gene ID" value="Cyan10605_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2679"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2844"/>
    <dbReference type="eggNOG" id="ENOG502Z7YX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095465_0_0_3"/>
    <dbReference type="OMA" id="RFSNYWW"/>
    <dbReference type="OrthoDB" id="1558391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00437">
        <property type="entry name" value="Ycf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003359">
        <property type="entry name" value="PSI_Ycf4_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02392">
        <property type="entry name" value="Ycf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20510" checksum="D42EE67457E63B3E" modified="2013-03-06" version="1">MTANNFIYKQQIIGSRRFSNYFWAIAVSFGGVGFLLAGLSSYLHTNLLIVSDTSELQFIPQGIALTFYGVAGTLLASYLWLMIILNVGSGYNEFDKKKGKVTIYRQGFLGKNRKIELVYDIDDIQAIRAEIKEGLNPKRVLYLRVKPKRDIPLTSVGEPMPLSQLENQGAELARFLTVPLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T4</accession>
    <name>K9Z8T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220851.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3075"/>
    <dbReference type="EnsemblBacteria" id="AFZ55132">
        <property type="protein sequence ID" value="AFZ55132"/>
        <property type="gene ID" value="Cyan10605_3075"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3075"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168933_0_0_3"/>
    <dbReference type="OMA" id="GLAWWAR"/>
    <dbReference type="OrthoDB" id="1863598at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014945">
        <property type="entry name" value="DUF1816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08846">
        <property type="entry name" value="DUF1816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10034" checksum="CE208C6B0814E9E6" modified="2013-03-06" version="1">MREQLITVLDFFGLACWLEITTNHPECIYYFGPFLSQREAQSYSQGYIEDLKGENAVGIITKFKRCKPKTLTIFDENISYSKSAIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z933</accession>
    <name>K9Z933_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220615.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2826"/>
    <dbReference type="EnsemblBacteria" id="AFZ54893">
        <property type="protein sequence ID" value="AFZ54893"/>
        <property type="gene ID" value="Cyan10605_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2826"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3003"/>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086007_1_0_3"/>
    <dbReference type="OMA" id="MVMPAWD"/>
    <dbReference type="OrthoDB" id="1904504at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="27607" checksum="4B1A2630E79DFAA1" modified="2013-03-06" version="1">MTTSFTTSDEFDPQDEGFGAEADYPSAFGITFTPKISGIAIGVGGFLIAGYLFFSQVMPVLGELSELNKQKQEKQEQLNQLSSNELEQILARKQGELEEAKDLKGDVLQLFAQTQNLETLLLDVNNFANLSNIKMNSYVPTGDKEKVADDSFGTLAANNLQVQTYNLDIEGGFSQLQFFLQDLERLQPLLVVQNLNTSILEPPIYLLENNSLSVVQEPTLKTTLTLKAVFPDLQPAPEAPAPEGEQPTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9B2</accession>
    <name>K9Z9B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220697.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2916"/>
    <dbReference type="EnsemblBacteria" id="AFZ54978">
        <property type="protein sequence ID" value="AFZ54978"/>
        <property type="gene ID" value="Cyan10605_2916"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2916"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3103"/>
    <dbReference type="eggNOG" id="COG1547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125317_1_0_3"/>
    <dbReference type="OMA" id="NWRGAVI"/>
    <dbReference type="OrthoDB" id="1858218at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="15436" checksum="55B32B6021E09765" modified="2013-03-06" version="1">MDNIELQKAIAEFNQQKFYDCHDTLEAIWMESVEPDKTFYQGILQVAVGCYHLTNINWKGAVILLGEGIRKLREYEPEYLDINVDKLVEESYDLLLALQQIDPDSVSIFCQKLLSQELQNNLSFPIIKTITYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H9</accession>
    <name>K9Z9H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221100.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3340"/>
    <dbReference type="EnsemblBacteria" id="AFZ55382">
        <property type="protein sequence ID" value="AFZ55382"/>
        <property type="gene ID" value="Cyan10605_3340"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3340"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3557"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_1_3"/>
    <dbReference type="OMA" id="DIHHLTC"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15857" checksum="C20CFDD010EC0550" modified="2013-03-06" version="1">MLIKLTKNQQKILQILKSINQEITAQELYIKLRESKLKIGLATVYRTLNTLHLKGFVQERNSLNGESLYSLISDNHHHTHHFNCINCGESFLLKQKLCPVDDMFNQWCSSQNFKLYYHTLEFFGICEACQEKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L9</accession>
    <name>K9Z9L9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Cytochrome b6-f complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">17 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">petD</name>
        <name evidence="12" type="ordered locus">Cyan10605_3019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9 10">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the cytochrome b family. PetD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220797.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3019"/>
    <dbReference type="EnsemblBacteria" id="AFZ55078">
        <property type="protein sequence ID" value="AFZ55078"/>
        <property type="gene ID" value="Cyan10605_3019"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3019"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3217"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112652_0_0_3"/>
    <dbReference type="OMA" id="KKGMGHN"/>
    <dbReference type="OrthoDB" id="1414927at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01344">
        <property type="entry name" value="Cytb6_f_subIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005870">
        <property type="entry name" value="Cyt_b6/f_cplx_suIV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000033">
        <property type="entry name" value="B6f_17K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01156">
        <property type="entry name" value="cytb6/f_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="11">
        <location>
            <begin position="70"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="18290" checksum="5681B099238324D8" modified="2013-03-06" version="1">MSNPNSQLIKKPDLNDPKLRAKLAQNMGHHYYGEIAWPNDILYMFPVCILGALGLIVGLAILDPAMIGEPADPFATPLEILPEWYLYPVFQILRILPNKLLGIACQAAIPLGLMLVPFIESVNKFQNPFRRPIAMTVFLFGTLVTLWLGAGSVFPIDKSLTLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Q1</accession>
    <name>K9Z9Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221028.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3264"/>
    <dbReference type="EnsemblBacteria" id="AFZ55310">
        <property type="protein sequence ID" value="AFZ55310"/>
        <property type="gene ID" value="Cyan10605_3264"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3264"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001223_0_0_3"/>
    <dbReference type="OMA" id="WIFELNE"/>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="2058" mass="225207" checksum="CBCFA8AAAF88B1C7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T5</accession>
    <name>K9Z9T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221200.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3442"/>
    <dbReference type="EnsemblBacteria" id="AFZ55482">
        <property type="protein sequence ID" value="AFZ55482"/>
        <property type="gene ID" value="Cyan10605_3442"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3442"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3667"/>
    <dbReference type="eggNOG" id="COG2389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111923_0_0_3"/>
    <dbReference type="OMA" id="RTHDRIT"/>
    <dbReference type="OrthoDB" id="1534088at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019250">
        <property type="entry name" value="DUF2227_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39085">
        <property type="entry name" value="PTHR39085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09988">
        <property type="entry name" value="DUF2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="21965" checksum="98A37AC855817238" modified="2013-03-06" version="1">MPSGKIHDQITWFCLPLVIILFFIVTKSLLLTALGGFGFIFSGLMFGPDLDIYSIQFQRWRFFRFIWLPYQKTLKHRSIFSHGFLLGTLIRVIYLSLILFILAILGVAIAQLIFGFGWHWQKFIFNSYGVLKNNYWQEVLSLFIGLELGAMSHYLADDIGSRWKSHQKKKPVSRKKNKKVVKKTSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Z0</accession>
    <name>K9Z9Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S3Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55173">
        <property type="protein sequence ID" value="AFZ55173"/>
        <property type="gene ID" value="Cyan10605_3122"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3122"/>
    <dbReference type="HOGENOM" id="CLU_3078975_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="52" mass="5982" checksum="9119F7D0D5693D77" modified="2013-03-06" version="1">MGYSCYPYYIGHHVTKDLMRSRCGLPNRTSQQTHHKFSSMSDGEKGNLMNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA02</accession>
    <name>K9ZA02_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3378"/>
    <dbReference type="EnsemblBacteria" id="AFZ55420">
        <property type="protein sequence ID" value="AFZ55420"/>
        <property type="gene ID" value="Cyan10605_3378"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3378"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3596"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_1_0_3"/>
    <dbReference type="OMA" id="GWLGKPH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="368" mass="41475" checksum="97EAEF683D348DB7" modified="2013-03-06" version="1">MIMDLDILSMTLIFRWLIGWILMWNLPRLPDIAVIGSPKVSVLIPARNEEKSLPHLLTALNNQSFKPYEIIVIDDQFIDNTANIAQQTGVKVIQNNFLPKGWTGKNWALKTGYNNSSGDILVFLDADTEPGQDLLRRLVATVQHLGGLVSIQPYHRTERPYEQLAMLFNLVGLMSVKLGARGGVAFGPAMATSRENYELVGSHEVVAKYVVEDWFMAHAYENSGLPVSAYIGYEQLNYRMYPDNIQNLIDGFDKNFATAAGEVSWVRMFAVLLWLSGLFWAAWCFPASLFGLPMVGNQSLLYNGVLYFAFAIQLAIVIKPVGSFRLTTFFFPIPVVFFLAVFIKSILKLKHGQIEWKGRKISTRIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA15</accession>
    <name>K9ZA15_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="4">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_3137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220907.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3137"/>
    <dbReference type="EnsemblBacteria" id="AFZ55188">
        <property type="protein sequence ID" value="AFZ55188"/>
        <property type="gene ID" value="Cyan10605_3137"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3137"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3344"/>
    <dbReference type="eggNOG" id="COG3288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_2_1_3"/>
    <dbReference type="OMA" id="VIGHVHH"/>
    <dbReference type="OrthoDB" id="464096at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_N" evidence="13">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="12">
        <location>
            <begin position="165"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="56399" checksum="1BFACC4875AF2D35" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA16</accession>
    <name>K9ZA16_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecB family nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221153.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3393"/>
    <dbReference type="EnsemblBacteria" id="AFZ55435">
        <property type="protein sequence ID" value="AFZ55435"/>
        <property type="gene ID" value="Cyan10605_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3393"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3613"/>
    <dbReference type="eggNOG" id="COG2251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044183_0_0_3"/>
    <dbReference type="OMA" id="LHYGETE"/>
    <dbReference type="OrthoDB" id="703621at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="337"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="537" mass="62639" checksum="A5156F00AE358D31" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD1</accession>
    <name>K9ZAD1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221267.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3517"/>
    <dbReference type="EnsemblBacteria" id="AFZ55550">
        <property type="protein sequence ID" value="AFZ55550"/>
        <property type="gene ID" value="Cyan10605_3517"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3517"/>
    <dbReference type="eggNOG" id="ENOG502ZBDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655155_0_0_3"/>
    <dbReference type="OMA" id="ETELNDM"/>
    <dbReference type="OrthoDB" id="1388627at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013489">
        <property type="entry name" value="CRISPR-assoc_prot_Csm6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09659">
        <property type="entry name" value="Cas_Csm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="50167" checksum="90620F53C22BFE74" modified="2013-03-06" version="1">MASILFSFVGNQDPVSHNTNEEGSIVTLVRYLLAQQKTIKKIILLYTETTAKGAKETQEWLLDILENSPFKPEDFSLIQVQEKLSTDPVNLSLVIEEVKTQIKKIQEIQKGDDILELNSSSGTPTMKASLGVLQGAGYLPKSNIWQVRNPREMREGQARVFKTNVDILKQEFDIKVIKEQVSNYNYNGALKTLSNSSLVDNGIGYFLQYGAYRLAFNFKDASEYIRDFRSFFEERLTKEINRLASKNQESILIELYYHILAHLKTKEYSQFLILVFGFQEFVLKFLVRKFISPDLLNKSWNQNLKQSVINACNNYEHGELRKYVQKYRQYNQTLQIDKMSRIVMLRIIQYPSFSCPKSLIDNLLHLESYCDKRNELVHQFEGVSESDITETELNDMVNKIQSILSDLFPDSFIKESCFAVLNKKIMAKLINSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAH3</accession>
    <name>K9ZAH3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221106.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3346"/>
    <dbReference type="EnsemblBacteria" id="AFZ55388">
        <property type="protein sequence ID" value="AFZ55388"/>
        <property type="gene ID" value="Cyan10605_3346"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3346"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3564"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_3"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="29483" checksum="CF8F00C41D1413C6" modified="2013-03-06" version="1">MTRVIVITSGKGGVGKTTITANLGTAVAQLGKKVCLIDADFGLRNLDLLLGLEQRVVYTIIDALSGECTLEKAIVKDKRTEGLHLLPAAQNRTKDAITPEQMKEVVEQLSPNFDYIFVDCPAGIEMGFRNAISAAKEALIVTTPEVAAVRDADRVVGLLESENMSNIRLIVNRLRPEMVQMDEMLSVEDILDLLVVPLIGIVPDDKKIITSSNKGEPLVLSPQDSLPAMAIKNIARRINGSDVPFLDFMTTQDNFITKIRRFFGFSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZC6</accession>
    <name>K9YZC6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218023.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0134"/>
    <dbReference type="EnsemblBacteria" id="AFZ52291">
        <property type="protein sequence ID" value="AFZ52291"/>
        <property type="gene ID" value="Cyan10605_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0134"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.138"/>
    <dbReference type="eggNOG" id="COG4031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154665_0_0_3"/>
    <dbReference type="OMA" id="WNHSTHL"/>
    <dbReference type="OrthoDB" id="1888942at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018664">
        <property type="entry name" value="DUF2103_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09876">
        <property type="entry name" value="DUF2103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="10606" checksum="046D0885B92D6BED" modified="2013-03-06" version="1">MSKSSEGRIVWNHSTHLDGLIPILEKLITYEGVKTVTPAVLSRSRSHSPHMKLKISVPIRGGFKLIARCGKSVQEVFVITELDKSRLEEIIKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZQ6</accession>
    <name>K9YZQ6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0248"/>
    <dbReference type="EnsemblBacteria" id="AFZ52399">
        <property type="protein sequence ID" value="AFZ52399"/>
        <property type="gene ID" value="Cyan10605_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0248"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.257"/>
    <dbReference type="eggNOG" id="ENOG5031EDU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159819_0_0_3"/>
    <dbReference type="OMA" id="CENLYVE"/>
    <dbReference type="OrthoDB" id="2049035at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="15855" checksum="6D71A49ADD6FBAA9" modified="2013-03-06" version="1">MLPPSILFDYLNKVEQVIVQCENLYVELYIEEIITPKRANLKIRLRFHQTHLLQISEAIEIKENQLNFLDYRYHFQDESNYLIFRYDSTPHFPNLSTFPHHKHLPDDVISCQKPTIDQVLNEVIKYFENYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZV5</accession>
    <name>K9YZV5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ordered locus">Cyan10605_0301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218181.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0301"/>
    <dbReference type="EnsemblBacteria" id="AFZ52449">
        <property type="protein sequence ID" value="AFZ52449"/>
        <property type="gene ID" value="Cyan10605_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0301"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.313"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_0_3"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="3"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="340"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="481" mass="54786" checksum="7A29308AF415B8FE" modified="2013-03-06" version="1">MSVRVRIAPSPTGNLHIGTARTAVFNWLFAHRYQGSFILRVEDTDLERSKAEYTENIKSGLQWLGLNWDEGPFFQTERLDLYRQAIQTLLNKGLAYPCYCTPEELEAMREQQKANNQAPRYDNRHRNLTPEEIAEFEAQGRKPVIRFKIDDSRQIVWKDLIRGSVTWQGSDLGGDMVIARMPEKEGDRFGQPLYNLAVVVDDIDMNITHVIRGEDHIANTAKQILLYQALEGKVPEFAHTPLILNSEGKKLSKRDGVTSIDDFRKMGFVAPAIANYMTLLGWTSPDGEEIFTLDEAATKFSLERVNKAGAKFDWDKLDWINSQYLHQMPAEDLLPLITSYWQEAGYQFNLDTDKDWLLEITALIAPSLTRLTDAVKEAQLFFNNDFSLSSEAQEFIHSVGVKEVLEQVIDSLNEDLTIDSANVIIKQITKDLNVKKGLVMRSLRVGLTGELHGPDLLQTWSLLHQKGVDKNRLQFVLDSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZV8</accession>
    <name>K9YZV8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218217.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0339"/>
    <dbReference type="EnsemblBacteria" id="AFZ52486">
        <property type="protein sequence ID" value="AFZ52486"/>
        <property type="gene ID" value="Cyan10605_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0339"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.354"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_3"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="14198" checksum="1C3BEE1A259AC040" modified="2013-03-06" version="1">MSQKKVIFTENAPFPLGPYSQAISATGELIFLAGQIPLNPETGEIVGEGDIKAQTRQVMKNIEAILIESGVNWSNVVKTGVFLSDLTNFVPMNEVYAEYFKEQPPARACVEVSRLPKDVLVEIECIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZX3</accession>
    <name>K9YZX3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0355"/>
    <dbReference type="EnsemblBacteria" id="AFZ52501">
        <property type="protein sequence ID" value="AFZ52501"/>
        <property type="gene ID" value="Cyan10605_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0355"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="CWLMAEK"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_1"/>
    </dbReference>
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        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
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        <property type="entry name" value="TPR_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48452"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="539" mass="63514" checksum="71B65527D1179D48" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0C1</accession>
    <name>K9Z0C1_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ52614">
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        <property type="gene ID" value="Cyan10605_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0472"/>
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    <dbReference type="OMA" id="YLMQNIP"/>
    <dbReference type="OrthoDB" id="1548467at2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
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        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="22946" checksum="20054BFDFFCC2D7E" modified="2013-03-06" version="1">MKKEYYRMSDNPSLFLPESQLLILNIVCALAWADNELSEEETEILLEKFKSNLPPEPEPIYFDDPDPFYNTMGLSSFTVAEQTQARVNAEIAFKDILNRYKQNPIPLSDLVSQLKTNEDRCLCAKLAYVVIKASPDNQGNLICADEKMVYRQLIQLLNLDPEVVQKIEQRADYELDKFQHPFKAFMGNVKKFFLKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K5</accession>
    <name>K9Z0K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ52252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0093"/>
    <dbReference type="EnsemblBacteria" id="AFZ52252">
        <property type="protein sequence ID" value="AFZ52252"/>
        <property type="gene ID" value="Cyan10605_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0093"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.95"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105759_0_0_3"/>
    <dbReference type="OMA" id="PNWLLIW"/>
    <dbReference type="OrthoDB" id="1617255at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="19252" checksum="8626E0AD609764FF" modified="2013-03-06" version="1">MKVWQNFWWQRLIIIVSIAACCILLMVRISGLELLGVTPNWLLIWLVTWSVRRNIWQSAIASICLGLIWDSLTGVFPSHVLGLLVVGIFTSNVYSKEYIKEDLISIMLIVFGMAIINETITALQYSIQTQVPLTDIWLNYQKNSLTSAIISSLWTPLVYYPLNYLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M5</accession>
    <name>K9Z0M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218430.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0558"/>
    <dbReference type="EnsemblBacteria" id="AFZ52699">
        <property type="protein sequence ID" value="AFZ52699"/>
        <property type="gene ID" value="Cyan10605_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0558"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.589"/>
    <dbReference type="eggNOG" id="ENOG5032RJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144128_0_0_3"/>
    <dbReference type="OMA" id="ENWYFER"/>
    <dbReference type="OrthoDB" id="1839951at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014964">
        <property type="entry name" value="DUF1830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08865">
        <property type="entry name" value="DUF1830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="116" mass="13329" checksum="EAE5F52564262AA9" modified="2013-03-06" version="1">MAQILDAIPNNENDSILCCYVNATSQIQVARITNIENWYFERVVFPGQRLMFETLPEALLEIHSGMMASAILSDTIPCKRLCISEEKIEEKKEDEDSSLYNKRKEDESEKLEVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P5</accession>
    <name>K9Z0P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218455.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0585"/>
    <dbReference type="EnsemblBacteria" id="AFZ52724">
        <property type="protein sequence ID" value="AFZ52724"/>
        <property type="gene ID" value="Cyan10605_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0585"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041901_0_0_3"/>
    <dbReference type="OMA" id="WELGWLA"/>
    <dbReference type="OrthoDB" id="1759826at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="542" mass="59658" checksum="672A7EE4A9DB40C8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S7</accession>
    <name>K9Z0S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218490.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0620"/>
    <dbReference type="EnsemblBacteria" id="AFZ52759">
        <property type="protein sequence ID" value="AFZ52759"/>
        <property type="gene ID" value="Cyan10605_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0620"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007617_0_0_3"/>
    <dbReference type="OMA" id="WNIHERE"/>
    <dbReference type="OrthoDB" id="77009at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="606"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="804" mass="93733" checksum="8EDE049E02720476" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T4</accession>
    <name>K9Z0T4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3 8">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">comB</name>
        <name evidence="9" type="ordered locus">Cyan10605_0186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218074.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0186"/>
    <dbReference type="EnsemblBacteria" id="AFZ52342">
        <property type="protein sequence ID" value="AFZ52342"/>
        <property type="gene ID" value="Cyan10605_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0186"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.195"/>
    <dbReference type="eggNOG" id="COG2045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070028_0_1_3"/>
    <dbReference type="OMA" id="RLFMSTT"/>
    <dbReference type="OrthoDB" id="1617556at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00490">
        <property type="entry name" value="ComB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="242" mass="26419" checksum="F79EAFC9BF2ADCCC" modified="2013-03-06" version="1">MKISVYYTPESTPENEIPDCAVVIDVLRATTTIVTALNNGAKSVKAYSDLDLLTKESNLLPPESRLRLGERGGKKVDFCDLGNSPLDCTVETVSGKQLFISTTNGTRSLQRVQEAKTVIAGAMINYQAVVDYLQEKQPETLWLLGSGWEGGYSLEDTVCAGAIASLLVDTGKPDMIGNDEVIASIALYQQWQDKLLDLFKLSSHGQRLLRLALDDDLKYCSQKNITDTLPIQTSLGLVSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T5</accession>
    <name>K9Z0T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamentous hemagglutinin family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218542.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0673"/>
    <dbReference type="EnsemblBacteria" id="AFZ52811">
        <property type="protein sequence ID" value="AFZ52811"/>
        <property type="gene ID" value="Cyan10605_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0673"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.709"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001178_0_0_3"/>
    <dbReference type="OMA" id="QANANGW"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05860">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01901">
        <property type="entry name" value="adhes_NPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939061" evidence="1">
        <location>
            <begin position="26"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="domain" description="Haemagg_act" evidence="2">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="2430" mass="256151" checksum="3D12E8AE4B74FFE6" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z125</accession>
    <name>K9Z125_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218637.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52906">
        <property type="protein sequence ID" value="AFZ52906"/>
        <property type="gene ID" value="Cyan10605_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0773"/>
    <dbReference type="HOGENOM" id="CLU_2536957_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9376" checksum="6E284405EE1D4792" modified="2013-03-06" version="1">MLSIEVQNFAEKLNQFSLEDKQWLLEKLQGEINAFRDSNSTEENNFGQINKTFNITPASSGSGFNDTVINHDQVFANSIFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z194</accession>
    <name>K9Z194_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin/ G-protein interacting-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218665.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0801"/>
    <dbReference type="EnsemblBacteria" id="AFZ52934">
        <property type="protein sequence ID" value="AFZ52934"/>
        <property type="gene ID" value="Cyan10605_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0801"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692563_0_0_3"/>
    <dbReference type="OrthoDB" id="1821834at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="18578" checksum="179DA7E18B6ACB16" modified="2013-03-06" version="1">MFEEVNEQIKSKVLALFFMKFKISPTYSLTIIEKWFTENSWADWETLYNLIQNALVRVENNNLINLYEQKICQLVNDMRGLGGIEIKNRNYRLKTYPLCFIGSEAVNWMEKKYDISKAEALKLGQTLINEKIIHHVTDDHDFKNDYLFYRFYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E5</accession>
    <name>K9Z1E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter, chromate ion transporter (CHR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218757.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0896"/>
    <dbReference type="EnsemblBacteria" id="AFZ53026">
        <property type="protein sequence ID" value="AFZ53026"/>
        <property type="gene ID" value="Cyan10605_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0896"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.941"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_0_0_3"/>
    <dbReference type="OMA" id="YQGAVGH"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="376" mass="40668" checksum="DC41728A14E3FBED" modified="2013-03-06" version="1">MKQSLSEIAIVFLKLGAIAFGGPAAHIAMMDKEIVEKRQWLSREKLLDLLGVTNLIPGPNSTELAIHIGYEKAGWRGLIVAGSCFILPAMAIVWLLAILYVRFESLPSSSGLLYGIKPVVIAIIIQALWKIGKKAAKDTPTTIGGVMATVAFFLGLDEILILLLIGLGVMITKTVIDNKNNLGGLFFLPFLAVSPSISFSPSGINIFLAFLKIGSILYGGGYVLLAFLQRDLVENYQWLTSEQLLDAIAVGQLTPGPIFTTATFVGYLIAGNKGAIMATIGIFLPSFILVLLVNPWVEKIRQSVQAGNFLDGVNAASLGLMAGVTYILMTNSVTDLFTLFLVIITTIVIFRYQINSVWLVLIGGLAGFLYYYLISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H5</accession>
    <name>K9Z1H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA sulfur modification protein DndE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217920.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0027"/>
    <dbReference type="EnsemblBacteria" id="AFZ52188">
        <property type="protein sequence ID" value="AFZ52188"/>
        <property type="gene ID" value="Cyan10605_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0027"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.29"/>
    <dbReference type="eggNOG" id="ENOG50307RI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162722_0_0_3"/>
    <dbReference type="OMA" id="ILCRWAF"/>
    <dbReference type="OrthoDB" id="1900450at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014969">
        <property type="entry name" value="DNA_S_DndE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038472">
        <property type="entry name" value="DndE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08870">
        <property type="entry name" value="DndE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03184">
        <property type="entry name" value="DNA_S_dndE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15315" checksum="F7172BDDB558D207" modified="2013-03-06" version="1">MRSPIERIKLSKKAKDQLIKLRKVTKIEQWNILCRWGFCRSLREKHTPAPYPIPADSNVEMSWNTFGGEIAEILLLALIHRCHQDGFETNAETLNQQFRLHLHRGINYLVTDLESKTLSDFVALGIKKDDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H9</accession>
    <name>K9Z1H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218167.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0286"/>
    <dbReference type="EnsemblBacteria" id="AFZ52435">
        <property type="protein sequence ID" value="AFZ52435"/>
        <property type="gene ID" value="Cyan10605_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0286"/>
    <dbReference type="eggNOG" id="ENOG5032X6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316880_0_0_3"/>
    <dbReference type="OMA" id="EAIRDEW"/>
    <dbReference type="OrthoDB" id="2037984at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="12480" checksum="826D9B182D94DB46" modified="2013-03-06" version="1">MAEQTKFNRQDAEDLLRELQKFNNILNYEWIKVLRKWETLQSCWHDKQFEEFEPLFQKFKANYQDAENKSEEFIRFIQEQITISEERQRVLSNFQRIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L5</accession>
    <name>K9Z1L5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ordered locus">Cyan10605_0322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218202.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0322"/>
    <dbReference type="EnsemblBacteria" id="AFZ52470">
        <property type="protein sequence ID" value="AFZ52470"/>
        <property type="gene ID" value="Cyan10605_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0322"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.336"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_3"/>
    <dbReference type="OMA" id="DKRRQPI"/>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="156"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="648" mass="76653" checksum="3CA554444F0782F2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M4</accession>
    <name>K9Z1M4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ordered locus">Cyan10605_0934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218795.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0934"/>
    <dbReference type="EnsemblBacteria" id="AFZ53064">
        <property type="protein sequence ID" value="AFZ53064"/>
        <property type="gene ID" value="Cyan10605_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0934"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.982"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_3"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="111"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ53064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="457" mass="50358" checksum="C28CC535593D82AB" modified="2013-03-06" version="1">MGKVYIIGLGKSGIAAAKILKKNHEEVTIYDSSNSPSLEIIKNDLAKENIVVKLGENLPLNNVQNPDLIVVSPGVPWDIPILEEARRKGIKTIGEMELAWQYLSKTPWIGITGTNGKTTTTALVEAMLKMGGIKTSACGNIGYAACDLALESLDNPLEWVVAEISSYQIESSMDLSPRIGIWTTFTPDHLARHKTLENYHRIKASLLQRSYLKILNGDDPYLHNFGLDLDWKNVYWTSVRGKEYLLGDIEKGVYLEDSWIVAFKELIAPVSLFKMVGKHNLQNLLMATAAARLAGVSKKAIADTISSFTGVPHRLELITNIDGVAYINDSKATNYDAAQVGLDSVASPTILIAGGEAKEGDDTAWINTIKEKCVSVLLIGEAASFFAERFEASGFGQYEIVETMENAVKRARELASDLKAKVVLLSPACASFDQYQNFEQRGENFRQICYDLTQKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R0</accession>
    <name>K9Z1R0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ordered locus">Cyan10605_1013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218872.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1013"/>
    <dbReference type="EnsemblBacteria" id="AFZ53141">
        <property type="protein sequence ID" value="AFZ53141"/>
        <property type="gene ID" value="Cyan10605_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1013"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1071"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_3"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="288"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="780" mass="91727" checksum="3350E9887B78B72C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V2</accession>
    <name>K9Z1V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218902.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1045"/>
    <dbReference type="EnsemblBacteria" id="AFZ53171">
        <property type="protein sequence ID" value="AFZ53171"/>
        <property type="gene ID" value="Cyan10605_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1045"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562248_0_0_3"/>
    <dbReference type="OMA" id="HYDHWHY"/>
    <dbReference type="OrthoDB" id="1456602at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="486" mass="54971" checksum="498F1C6CF71AAF82" modified="2013-03-06" version="1">MDSAISFANGSQILALNSCDRLCYVIQPFIQEILNQFVQLNSLDQAIVIGAKKHHKIAEKLFEFELDNPAETFSLKEQFLFPEKSPILSLQYGNTRYPLFLEKYGSEIIYDQSTLPAIHKLFYLCGQSNLSYEQICGQLEQPMIDFLDKLINTKVVQNKPNQPKSLELKTPGVFRLQHAALLYRTKTTGILVDPHLHSNYGIPNLKKDISRAMLGDNVDAILISHPHYDHWHYPTLMMFPPEIPIIVPKVPRGSIMCEDMKARLESLGFTNVMAVDWYAETILVGDIEINVLPFYGEQPLVPEFNQPKHPDLRNWGNTYLINTEYYKSWFLIDSGDDDMGTMAEVAEYVKEKFGTLDHVLSNFQPLSYNSIGTDLSGWGIDIVANLLSNPQIFSVTNKKEGEHIALLGPQGVAKICSIVGAKYCLPYADSWAELGESGIHDATLIKDVKEELHNLDCLTQVIPWKIGDQFVINGTSKIEENIFINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W3</accession>
    <name>K9Z1W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureE</name>
        <name evidence="6" type="ordered locus">Cyan10605_0436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218311.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0436"/>
    <dbReference type="EnsemblBacteria" id="AFZ52580">
        <property type="protein sequence ID" value="AFZ52580"/>
        <property type="gene ID" value="Cyan10605_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0436"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.460"/>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093757_2_0_3"/>
    <dbReference type="OMA" id="AYDARCK"/>
    <dbReference type="OrthoDB" id="1663151at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_C" evidence="5">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17349" checksum="3F1BDDDCE86BBC83" modified="2013-03-06" version="1">MIILTKKSKFFLRNKVNLEIYLTAEERTKVKQKIRVDTISENENKYIKLNLERGNVLMEGDILTNDDESFFVEIKAKLEPVITVKALDTLNLLKAAYHLGNRHVSLEINSDYLRFSPNHVLESMLSKLGVSFCQETAPFYPELGAYKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W8</accession>
    <name>K9Z1W8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Cyan10605_0441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218316.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0441"/>
    <dbReference type="EnsemblBacteria" id="AFZ52585">
        <property type="protein sequence ID" value="AFZ52585"/>
        <property type="gene ID" value="Cyan10605_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0441"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.466"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_3"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="305" mass="33421" checksum="BD2FE0EF55FD6E9B" modified="2013-03-06" version="1">MPKIGVIYNDIKPIACQVATELKEKLTAEGYQVHLATGYAGILGYSRPDRPVCYSAIEKIAPFGFDQDMKFVIVLGGDGTVLSASRQVSPHNIPILAVNTGHLGFLTEIYLNQLPKILDAVLRDEYEVEERSMMRVQVIRDGHLLWEALCLNEAVIHREPLTSMCHFEIAIGRHAPVDIAADGIIISTPTGSTAYSLSAGGPVVTPDVPVFQLAPICPHSLASRALVFSNQEPVTIYPATPNQMVMVVDGNAGCYILPDDQVVIVRSPYPAKFIRLQSPEFFRILREKLGWGLPHIAKPTSVEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X6</accession>
    <name>K9Z1X6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218120.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52388">
        <property type="protein sequence ID" value="AFZ52388"/>
        <property type="gene ID" value="Cyan10605_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0235"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.245"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1547701at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="21508" checksum="C4C7CDBC4D633E02" modified="2013-03-06" version="1">MNFFHRRSIRLKHYDYSQQGVYFVTICTQYRQCLWGEIKQDQVLLNHLGSISLQCWLEIPEHFPSVELDVFVIMPNHLHGILWIKESLNQEEKYNQFQKVVKGSIPSIVRSFKGAVTSKINQICQQKGTSLIWQRNYYEKVIKDEEMLNNVREYILNNPRNWEKDSEYSSSKNIIFDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z210</accession>
    <name>K9Z210_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein AbrB duplication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0278"/>
    <dbReference type="EnsemblBacteria" id="AFZ52428">
        <property type="protein sequence ID" value="AFZ52428"/>
        <property type="gene ID" value="Cyan10605_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0278"/>
    <dbReference type="eggNOG" id="COG3180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050210_2_0_3"/>
    <dbReference type="OMA" id="MQYVRVV"/>
    <dbReference type="OrthoDB" id="1050807at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017516">
        <property type="entry name" value="AbrB_dup"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007820">
        <property type="entry name" value="AbrB_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38457">
        <property type="entry name" value="PTHR38457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05145">
        <property type="entry name" value="AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038991">
        <property type="entry name" value="Protein_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03082">
        <property type="entry name" value="Gneg_AbrB_dup"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="363" mass="39561" checksum="0EFCA30E562288E0" modified="2013-03-06" version="1">MSSAILDYKNIIRIIGLIILAIAFSWFGEILNLPIPYLLIPLFLGVIVVVVEKKPQPLPKLFSVIGQAIIAIVTASRFSLETFTQAQNFFFPLLLCILITATLSLINGYVIYKWANIDLATSFLGCIPGAGPSLVAMSEDMGADAIAVAVLQYLRILMVSVIIPIIASFYTNQTPISPIIVTTNQRLLPSLPLIVNIILISIFVFISIKIGEKIQLPSNLFLAPFFCGLLIFSFSPYEIDIPSYIFRGGLLLLGLSIGVKFEVETIQKLLKAVLIEVGLVLLLIFTCFLAGYGFHLMTKIDTLTALLGSTPGGLTAMMATVIELGGDSALVLTMQMMRMLLILTLSPFFAASLMKKSSETTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z211</accession>
    <name>K9Z211_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218905.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1048"/>
    <dbReference type="EnsemblBacteria" id="AFZ53174">
        <property type="protein sequence ID" value="AFZ53174"/>
        <property type="gene ID" value="Cyan10605_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1048"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1109"/>
    <dbReference type="eggNOG" id="ENOG502ZAB0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456142_0_0_3"/>
    <dbReference type="OMA" id="CEYIAKF"/>
    <dbReference type="OrthoDB" id="903559at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="598" mass="67998" checksum="AFB454792C660163" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z229</accession>
    <name>K9Z229_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">Cyan10605_1124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1124"/>
    <dbReference type="EnsemblBacteria" id="AFZ53246">
        <property type="protein sequence ID" value="AFZ53246"/>
        <property type="gene ID" value="Cyan10605_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1124"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1189"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_0_1_3"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="35855" checksum="3D8BBDADD24E20DF" modified="2013-03-06" version="1">MEQIKRGVTIISSGSATSPQILDNHDLSKIVDTSDDWIKTRTGIQKRHICSSESLCDLAVKAGEKAILNAGLTSEDIDMIILATSTPDDLFGSASKVQGMLGASRAVAFDLTAACSGFVFALNTASQFLRNGVYQNILVVGADCLSRWVDWSDRTTCVLFGDGAGAVVCQSSEEKDNLLGFEMCSNGTLNGCLNLAFTGETQKLGNNHQVTQGKYNPITMNGREVYRFAVNKVPEVIEKALYKADLTTEKIDWLILHQANQRILDAVAERLNIPKWKVISNLSEYGNTSAASIPIALDEAVSKGKIRTGDTIVTSGFGAGLTWGATVFRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z269</accession>
    <name>K9Z269_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="5" type="synonym">rps2</name>
        <name evidence="7" type="ordered locus">Cyan10605_1107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218960.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1107"/>
    <dbReference type="EnsemblBacteria" id="AFZ53229">
        <property type="protein sequence ID" value="AFZ53229"/>
        <property type="gene ID" value="Cyan10605_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1107"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1171"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_3"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="30798" checksum="3BAA341230BD8C8D" modified="2013-03-06" version="1">MSVVSLKELLDSGVHFGHQTRRWNPKMSPYIYTARNGVHIIDLVQTAQLLEEAYAYLKKAAENGKKVLFVGTKRQAAGIIAQEAARCGAFYINQRWLGGMLTNWETIKSRVGRLKELEELEESGAINLRPKKEASVLRRELTKLQRYLGGIKDMRRVPDIVVIIDIRREHNAVKECEKLGLSVISMLDTNCNPELVDYPIPANDDAIRSIKLIIGKLADAIYEGRYGKAAAEGKLDEFMESVSAEAEYDYDDDEDYDDEDYEDDSDSEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A2</accession>
    <name>K9Z2A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0727"/>
    <dbReference type="EnsemblBacteria" id="AFZ52862">
        <property type="protein sequence ID" value="AFZ52862"/>
        <property type="gene ID" value="Cyan10605_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0727"/>
    <dbReference type="HOGENOM" id="CLU_3232491_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="43" mass="4886" checksum="A57E2F50A977B1AA" modified="2013-03-06" version="1">MIQQLEEAIIKLSELPETEQEAIAQIIFSTIESKKNQLMLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A9</accession>
    <name>K9Z2A9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218421.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0549"/>
    <dbReference type="EnsemblBacteria" id="AFZ52690">
        <property type="protein sequence ID" value="AFZ52690"/>
        <property type="gene ID" value="Cyan10605_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0549"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.579"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038555_0_0_3"/>
    <dbReference type="OMA" id="RYTPPTC"/>
    <dbReference type="OrthoDB" id="1551524at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025569">
        <property type="entry name" value="DUF4335"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14233">
        <property type="entry name" value="DUF4335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="492" mass="55579" checksum="28004C25AD0B7C22" modified="2013-03-06" version="1">MVINNSSSFRRYTPPTCTLEIYNPQPFWGKWRYQSFPQYFSFQLHFDDPRIPKDNRSSIIGDRTLLEKLRQLVDEYINLYLDDRQIVRDNQTCDIPQDEHTEFICLSRESDYSHKLYYHGIEPQRETVEVILTNTQLFDLINALEAYYYDVTKSNQELGEAISSNLGLSIFITALVCIIGGWFWWRYEQNLALQQNPIDNPSQSSEAEEFDDDIEKVIPPSPLDPQSLPSIVTPEVPEELRNRESLPPPESTITRPPDNSPTAEIPQNFPENNSQATLTMETPPPPSVNDLPPSTVNNNSQGMNSQPSLSQTISLQPSSSNSNTIPSSPPKLNKLPVLSSSNSSVPNLNSFTSEDVSPSQFALNNINKTNDITPPIVIKNPTLPENINNLDTSKLVAKKLPPTSAEVEVKQYFISQWQPPENLQQSIEYRLQINSEGQLTKVTPIGQVAIIYLDRTNMPLLGKKIASSLEEDSQATIRLILSPNGNVQTFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G0</accession>
    <name>K9Z2G0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilin polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219063.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1215"/>
    <dbReference type="EnsemblBacteria" id="AFZ53334">
        <property type="protein sequence ID" value="AFZ53334"/>
        <property type="gene ID" value="Cyan10605_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1215"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_5_0_3"/>
    <dbReference type="OMA" id="ICEATHP"/>
    <dbReference type="OrthoDB" id="1981258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031975">
        <property type="entry name" value="Pilin_GH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16734">
        <property type="entry name" value="Pilin_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="17928" checksum="E80D33D22F93690F" modified="2013-03-06" version="1">MKPEVTLKYLAYLRNKKANNEGFTLIELLVVVIIIGVLAAVALPNLLGQVGKARETELKNAVGTVNRSQQAYHFERQTFAPSISFLGVKLPQEYLTDTGMNLVASSDSASNFSENSNAATDGTRAFSGLISHSGGEFTQILCQSNEVTSSVAVPTNDTTCANGSAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z309</accession>
    <name>K9Z309_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219273.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1433"/>
    <dbReference type="EnsemblBacteria" id="AFZ53544">
        <property type="protein sequence ID" value="AFZ53544"/>
        <property type="gene ID" value="Cyan10605_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1433"/>
    <dbReference type="HOGENOM" id="CLU_186123_0_0_3"/>
    <dbReference type="OMA" id="YIPCREW"/>
    <dbReference type="OrthoDB" id="2024458at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025477">
        <property type="entry name" value="DUF4327"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14217">
        <property type="entry name" value="DUF4327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="9445" checksum="A20902BC0C380981" modified="2013-03-06" version="1">MTTQSIIPSYNHDLNFIRDEIRALLEKGCISRHQPLYVLANYVPPREWLNIERQLEEKDFLLRDRICDLLTEEKWDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z325</accession>
    <name>K9Z325_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219288.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1448"/>
    <dbReference type="EnsemblBacteria" id="AFZ53559">
        <property type="protein sequence ID" value="AFZ53559"/>
        <property type="gene ID" value="Cyan10605_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1448"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1536"/>
    <dbReference type="eggNOG" id="COG4803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097445_1_0_3"/>
    <dbReference type="OMA" id="IGFEDPQ"/>
    <dbReference type="OrthoDB" id="2059684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="172" mass="18423" checksum="BCC85DB1DEBB3F42" modified="2013-03-06" version="1">MSHLIAIAYDDIFKAEEVRLTLAKLQREHLIELEDAAVVVKNAKGKVKLKQAINLTAAGATSGGFWGLLIGTLFLVPLFGAAVGAATGAISGALSDIGVDDEFMRELGETLQPDTSALFILIKKVTPDKVLDEVSKYGGKILRTSLSKDDEEQLQEVLNNRGVLPLDESAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z377</accession>
    <name>K9Z377_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218549.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0680"/>
    <dbReference type="EnsemblBacteria" id="AFZ52818">
        <property type="protein sequence ID" value="AFZ52818"/>
        <property type="gene ID" value="Cyan10605_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0680"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.716"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_3"/>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="37488" checksum="DAA9F3EDEED99CD9" modified="2013-03-06" version="1">MPSKPELSLLIPCYNEEENLPVLFSRLESVLQTLNLNYEIVCINDGSKDNTLKCLVEFHQRDKRIKIINLSRNFGKEIAMSAGLDYTKGKTVIPIDADLQDPPELIIDLLAKWREGYDVVYAVRKTRQGESWIKRKTAEYFYSLIAKISTIPIPANTGDYRLLDEKVVKALRKIPERNRFMKGLFSWVGYKQTAIYFDRFPRYGGKTSFNYWKLWNFALDGITSFSSIPLKIWSYFGLFISFISLLYGLFLVLKTIISGVDLPGYASTIVAILFLGGIQLITLGVIGEYIARIYEEVKQRPLYLIRETYGIEDDLSSGFGVRSSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B0</accession>
    <name>K9Z3B0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0950"/>
    <dbReference type="EnsemblBacteria" id="AFZ53080">
        <property type="protein sequence ID" value="AFZ53080"/>
        <property type="gene ID" value="Cyan10605_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0950"/>
    <dbReference type="HOGENOM" id="CLU_1014592_0_0_3"/>
    <dbReference type="OrthoDB" id="2022738at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="30048" checksum="7C89851846DCAE1A" modified="2013-03-06" version="1">MIRGILVNMDKIKTKIGWKNNLDKLLFILASLYLILILGLWLKNRQQTVNSQSQTVNPNKQIISESNLIETNTINNQNTEENLLNDENISPNQEDIENQILSTGNNITSTLEIPPLPSNQSTVNNIPLPPPDLQPLPIPQPPQPVANSSITTNNLSNNNTKPNLTSSSSIPKVNKVPVIASLSKDNSNIPEQIALNSVPESTEEKTQGNYTLIGLVQLPDSKSVALFKVNNITEKVSLGKEIGATGWVLMAVNEKQAVVSKQNQSVYLQVGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R4</accession>
    <name>K9Z3R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219116.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1271"/>
    <dbReference type="EnsemblBacteria" id="AFZ53387">
        <property type="protein sequence ID" value="AFZ53387"/>
        <property type="gene ID" value="Cyan10605_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1271"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1342"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_3"/>
    <dbReference type="OMA" id="DLMIPRV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="39423" checksum="84CE27492BFA6392" modified="2013-03-06" version="1" precursor="true">MFNLFISVIIVLAGSAFCSLTETVLLSVSDIKVKQWAQSKKSSALVLLQIKKKMSRPIAAIVILNNIFNIVGSIIIGTFTTEALGSKWLGVFSAILTFLIIIFGEIIPKTLGQRYADNIALWLAFPTKFLAFILNPLVWLMEKITEPLTKGKVLPTTNEMEIKLLTNIGSNEGVIEADEAEMINRVFHLNDLSAYDLMTPRIIITYLKGDLTLSECQDTIIKSEHSRILVVQDSIDDVLGIAFKNELLTAVIKGKGSEKIANLAKNVNFVPETIRADLLLKNFQELRQHLMVVIDEYGGVSGVVTLEDVLEVLTGDIVDETDKTVNMREIARRKRERLLISKGIEDFSSFNHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R8</accession>
    <name>K9Z3R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218936.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1082"/>
    <dbReference type="EnsemblBacteria" id="AFZ53205">
        <property type="protein sequence ID" value="AFZ53205"/>
        <property type="gene ID" value="Cyan10605_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1082"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173858_0_0_3"/>
    <dbReference type="OMA" id="NGPWITE"/>
    <dbReference type="OrthoDB" id="892295at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27739" checksum="323E90FCFC1376D5" modified="2013-03-06" version="1">MNSNTYKIFGIGLPRSGTSSLNQALSILGYKSLHHPTYYIMDKLNGSFSFEGDWDALTNFGEHFYPQLDELYPNSKFILTTRDKEKWLNSCRWKYQEPSNNLGNAIRISIFGCDRFHESTYSYIYDQHTRNVIEYFKNRPNDLLVVDWGLGHGWKELCYFLNKPVPETPFPNKNSKQEIILLDRPINYKVKRNTGLNNIPNYFYSEILSQAFLGNKLAKIMVEFVKKNKFNKTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3S6</accession>
    <name>K9Z3S6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218946.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1093"/>
    <dbReference type="EnsemblBacteria" id="AFZ53215">
        <property type="protein sequence ID" value="AFZ53215"/>
        <property type="gene ID" value="Cyan10605_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1093"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1157"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_3"/>
    <dbReference type="OMA" id="WELDCSY"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="370" mass="40553" checksum="195665228C029187" modified="2013-03-06" version="1">MEIMIEDLMEQLVELGGSDMHIQAGAPVYFRISGKLTPIGDEPLNAQECQKLIFSMLNNTQRKTLEQEWELDCSYGVKGLARFRVNVYKERGCYAACLRALSSKIPNFDQLGLPDIVKEMSERPRGMILVTGQTGSGKTTTLAAMLDLINRTRAEHILTVEDPIEYVFPNINSLFHQRQKGEDTKSFANALKAALREDPDIILVGEMRDLETISLAITAAETGHLVFGTLHTSSAAGTIDRIIDVFPSAEQAQIRAMLSNSLLAVFAQTLAKKKNPKPGEFGRAMAQEIMIVTPAIANLIREAKAPQIYSAIQTGGKLGMQTMEQALANLVKTGTIAVEEALAKSSKPDELKRLLGSSMDSGMVTPSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Y2</accession>
    <name>K9Z3Y2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218819.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0958"/>
    <dbReference type="EnsemblBacteria" id="AFZ53088">
        <property type="protein sequence ID" value="AFZ53088"/>
        <property type="gene ID" value="Cyan10605_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0958"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1011"/>
    <dbReference type="eggNOG" id="ENOG502ZC57">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093159_0_0_3"/>
    <dbReference type="OMA" id="YWKVASL"/>
    <dbReference type="OrthoDB" id="1739258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021515">
        <property type="entry name" value="DUF3177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11375">
        <property type="entry name" value="DUF3177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="22984" checksum="016C734F24AAFB75" modified="2013-03-06" version="1">MEEILLKALVWTNYKLFLLICLVLPLILSVWSLKTQIPSIQRLLLIYWRVASLLAIAIYLFIPVWQIGYLAWFAGHILIVICLWFWADINDEIRDLPKSSLRLALTSWRWAVSLYGIISAIAFIPFLRCTFVPSASADTMCRLWLEAPWHYKSWFHPNSTTGFLGFLGMSGLIIYVIYFVYFLTFRLVKQGRIALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z1</accession>
    <name>K9Z3Z1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218829.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53098">
        <property type="protein sequence ID" value="AFZ53098"/>
        <property type="gene ID" value="Cyan10605_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0968"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1022"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103537_0_0_3"/>
    <dbReference type="OMA" id="DLVWAYP"/>
    <dbReference type="OrthoDB" id="2063459at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="18877" checksum="ED34E1290A66B20D" modified="2013-03-06" version="1">MFNKVQKIEPKEGQESVWDYPRPPRLEAFSGRIEIILNGVKIADTTSSYRVLETSHPPVYYLPPQDIQIQYLIPREGQSFCEWKGSAKYYDVCVDDKLIYKAAWYYPNPTPEFDAIAHYVAFYAGLMSECYVNGELVTPQPGGFYGGWITSNIVGPFKGVAGSWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z453</accession>
    <name>K9Z453_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)H-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NAD(P)H dehydrogenase, subunit J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NADH-plastoquinone oxidoreductase subunit J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit J</fullName>
            <shortName evidence="2">NDH-J</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ndhJ</name>
        <name evidence="6" type="ordered locus">Cyan10605_1410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cellular thylakoid membrane</location>
            <topology evidence="2 4">Peripheral membrane protein</topology>
            <orientation evidence="2 4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ53522">
        <property type="protein sequence ID" value="AFZ53522"/>
        <property type="gene ID" value="Cyan10605_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1410"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1490"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
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        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="Complex1_30kDa"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="2 4" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0793">Thylakoid</keyword>
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    <keyword evidence="1 2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="5">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003581"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="21360" checksum="204F4FB30FA7E5DD" modified="2013-03-06" version="1">MTEANNNNNPETENQQENNEVGEIVQAGITSQWLTENGFAHEVLEKDHSGVELIKVDPEFLIPIATALRAYGFNYLQCQGAYDLGPGKELVSFYHLLKVEDNITNPQEVRIKVYLNRENPQVPSVYWIWRGADWQERECYDMYGIIYEGHPNLKRILMPEDWVGWPLRKDYVSPDFYELQDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z482</accession>
    <name>K9Z482_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ppx/GppA phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.40" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219281.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1441"/>
    <dbReference type="EnsemblBacteria" id="AFZ53552">
        <property type="protein sequence ID" value="AFZ53552"/>
        <property type="gene ID" value="Cyan10605_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1441"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1526"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_4_2_3"/>
    <dbReference type="OMA" id="RISEGCY"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="354"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="541" mass="61216" checksum="3156BD5B4C8A892E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B4</accession>
    <name>K9Z4B4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219159.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1315"/>
    <dbReference type="EnsemblBacteria" id="AFZ53430">
        <property type="protein sequence ID" value="AFZ53430"/>
        <property type="gene ID" value="Cyan10605_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1315"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1388"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031448_0_0_3"/>
    <dbReference type="OMA" id="WARYRHQ"/>
    <dbReference type="OrthoDB" id="876054at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="559" mass="63159" checksum="3DE9C3EC731D6DBA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D9</accession>
    <name>K9Z4D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219781.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1961"/>
    <dbReference type="EnsemblBacteria" id="AFZ54056">
        <property type="protein sequence ID" value="AFZ54056"/>
        <property type="gene ID" value="Cyan10605_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1961"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2082"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608935_0_0_3"/>
    <dbReference type="OMA" id="SPWPLRI"/>
    <dbReference type="OrthoDB" id="1729773at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="176" mass="19925" checksum="88F96AB7E1077572" modified="2013-03-06" version="1">MTEKLTCPVCDRTEIETNICPNCETDLSTIKLLKELPQVEEKDNKKSQKLFIITLASVLIMGLLVGNLTGYFVSKNNFNNRLQAINQNKNQSTEVAKKSEAIKPELNWCGGFNYRVKSGDSLYMLGLRFYGDGDGWQLIFQANPTINNPQNLQIGQVILIPNLTELCQTNQSYMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H2</accession>
    <name>K9Z4H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219007.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1156"/>
    <dbReference type="EnsemblBacteria" id="AFZ53278">
        <property type="protein sequence ID" value="AFZ53278"/>
        <property type="gene ID" value="Cyan10605_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1156"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1223"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_144_1_3"/>
    <dbReference type="OMA" id="IRWKSPT"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="151"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="403" mass="45535" checksum="11E37EADFB34BCE5" modified="2013-03-06" version="1">MNLHSNTEQKLQNRRFLAGECIFREGDKGNIAYIIEKGLVEITTVVNDCPTVLNTLKEGEMFGELALVDGSPRSASAYAKTDVVLTVVTGEQVRSRIDDADPILKLLLIVVMKYFRLETGRLRNSKIDISTEDIEQKKQEYQSKIRQAIDLIRLESDLRNGFKRGELTLFYQPIINLKNNQIAGFEVLLRWFCHKRGHIAPDIFIPLAESTSLIIPIGEWILDQALDTIKKIKTITGKDIFLSINVAEKQISDGNFLPVLKEKINQSMVKPSQIKLEILERSLFEGEDALFLVEFCRDFGLPLVIDDFGTGYANLAYLKNFQFDTVKIDKCFVQNLDSNCKDQTICRALIDLSHGLNMTTVAEGIENEKQLDILLNLGCNFGQGYLFSPPVCLEDAIALLQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I3</accession>
    <name>K9Z4I3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ordered locus">Cyan10605_1953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219774.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1953"/>
    <dbReference type="EnsemblBacteria" id="AFZ54049">
        <property type="protein sequence ID" value="AFZ54049"/>
        <property type="gene ID" value="Cyan10605_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1953"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2075"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_3"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="227" mass="24495" checksum="D30422819AE09F92" modified="2013-03-06" version="1">MRSNFISATDIDIADYIDFALLQPTATRKDVENACKVAIQYNFASVCVYPSAVKVAAELLHNQKSKVCTVIGFPSGASTTNCKVFEAQEAVENGVQELDVVINLGWLREGNSELIYKEMASIVEETGQVIKAILETSVLTPTEKRLAAEICMDAGVSFLKTSTGWFGGATVEDVKFLQEITKGRIEIKASGGIKTLENAIALINAGATRLGTSKGVELVRQQKNQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J8</accession>
    <name>K9Z4J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219789.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1969"/>
    <dbReference type="EnsemblBacteria" id="AFZ54064">
        <property type="protein sequence ID" value="AFZ54064"/>
        <property type="gene ID" value="Cyan10605_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1969"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2090"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_11_3_3"/>
    <dbReference type="OMA" id="HERWIDS"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="334" mass="36047" checksum="45C4E14A4EE2BC6E" modified="2013-03-06" version="1">MTVTDVIKRYQEGDRDFRNTNLSKSNLSGIKLSNSNFSYSKMIETHLAWSDLERCFLLESDLRGAFLYGANLSFVKLKEAQLIEADLTKADLRGAQLHKADLQGATLSGAVLTWVSLYMANLPGVNLCGANLDGINLRGANLQGANLNWTNLNHARLSGANLRGATLYGIKLKGAFLNGLDLHGLNFSGMDLEEAKLSGTKLYGADFSGSNLTGAFFRRSVLHKANLKNVQLYHGQMKGAEIVQANLMKSNLSETDLRNADLSFANLNLVNLRGADLTGANLRGAYLWGACLNGAILKDTNLSGASLRDADLSGVNLSEAILEGATMPDGKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N5</accession>
    <name>K9Z4N5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-chelate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219829.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2010"/>
    <dbReference type="EnsemblBacteria" id="AFZ54104">
        <property type="protein sequence ID" value="AFZ54104"/>
        <property type="gene ID" value="Cyan10605_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2010"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2136"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_3"/>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29158" checksum="99EA312223D0F29A" modified="2013-03-06" version="1">MPLNSYNLSGGYDSRVIVHHLDLDLQQGEWLSLVGANGSGKSTFLKLLARILPPITGKVLLDGKEIHCLPPQTVAKRIAILPQQQIIPSGLTVRQLVSLGRTPHQSWYQWDLTKCDRIAVNEALAQTELESYADRPVSQLSGGERQRAFLALALAQNPQVLLLDEPTTYLDIHYQLQLLELLKRLHLEGLTIITVLHEINLAARYSDRIAFMRQGRLYTVGETEEVLTETNIAEVFNVEVMILNTPVGKQICPLTPSLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T9</accession>
    <name>K9Z4T9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219901.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2087"/>
    <dbReference type="EnsemblBacteria" id="AFZ54176">
        <property type="protein sequence ID" value="AFZ54176"/>
        <property type="gene ID" value="Cyan10605_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2087"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2218"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369758_0_0_3"/>
    <dbReference type="OMA" id="QRHVCFD"/>
    <dbReference type="OrthoDB" id="1816958at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21638" checksum="259F2D8082AA7EC3" modified="2013-03-06" version="1">MIIEGSLTLTNISLAAFFPELTDTLFSTQGIMVMLLVAYGGAMWLFLTSAPKVYTVMVSDLVIAQEFYENLLGLPVADVPLHYYYNYEQSLGASAFDPIYMGSGFNDTMVKPKDGLWYQLKKNTQLHIIGGASLGYKNCQRHVCFDGECLEALLLRVQARRLKYKIRSEKPLNFLVKDWDNRVIEMAEVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z519</accession>
    <name>K9Z519_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyanobacterial porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1734"/>
    <dbReference type="EnsemblBacteria" id="AFZ53837">
        <property type="protein sequence ID" value="AFZ53837"/>
        <property type="gene ID" value="Cyan10605_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1734"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1841"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018575_1_0_3"/>
    <dbReference type="OMA" id="SYHIEAF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="543" mass="59598" checksum="058CDC584A02DF23" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z524</accession>
    <name>K9Z524_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polypeptide-transport-associated domain protein FtsQ-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219569.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1739"/>
    <dbReference type="EnsemblBacteria" id="AFZ53842">
        <property type="protein sequence ID" value="AFZ53842"/>
        <property type="gene ID" value="Cyan10605_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1739"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085730_1_0_3"/>
    <dbReference type="OMA" id="YPQSLWR"/>
    <dbReference type="OrthoDB" id="1270665at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="281" mass="32421" checksum="67E16F9C5929A5DD" modified="2013-03-06" version="1">MANQTFVSTTTIRSRREERKKERRWRDFIAVVRFLMILSLTGGVFWFITLPNWVIKNSQQIDIEGNNLLSDDEVRSLIPLQYPQSLLKLSTQELGKNLQTLAPVNNVVIQKELFPPHLKISLEEKKPVAIALAPEIEEKTNKLTIQTIGYLDEDGVFVSNEVYHNLKENPEQLPTLKIIGAPQTYLPYWQELYGFLTQSTVKINTVDWQNPTNLVLLTDLGKIYLGAYTQKKFPQQLMVLEKLKVITAQVRREDIIYIDLTDPEIPSISKKEPVKEEKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z591</accession>
    <name>K9Z591_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unspecific monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219307.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1467"/>
    <dbReference type="EnsemblBacteria" id="AFZ53578">
        <property type="protein sequence ID" value="AFZ53578"/>
        <property type="gene ID" value="Cyan10605_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1467"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1556"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_3"/>
    <dbReference type="OMA" id="LFGHAQE"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="448" mass="52272" checksum="95FE835B5F4FF1C9" modified="2013-03-06" version="1">MVYVNQLSTPVWLQTVKWILNPPEYMSQAVKEYQDLFTAQITGFGNNILFVNHPDAIQQILTNDRQTFFADGELNTVLTPIVGYSSLLSLDGKRHKRERKLMMPPFHGDRMIYYGNSVQEIVDNLFSKFKTNDIFITRETMQEVSLQVILKVVFGLTEGDRFLQMAQLIKDILDRFNQPINISFLFYEWLRKDFGKWSPWGSFLRIKKRLDDLIYREIEERRKEKNSERVDMLSLLLEAKDENGEGLTNQELRDELMLILFAGHETTAIAMSWALYWIHYYPEVKERLLQELNTLPPDSDGMTIYKQPYLTAVCNETLRIYPVAMLTFPRVATEDVQLLGQTVKKGTIVTGCIYLTHQREDLYPNPNQFQPERFLHRQYSPYEFLPFGGGVRRCLGEALATYEMRLVVAKILREYDLELVTKKAVKPRRRGVVLSPKGGIPMKFLGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E3</accession>
    <name>K9Z5E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219502.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1670"/>
    <dbReference type="EnsemblBacteria" id="AFZ53775">
        <property type="protein sequence ID" value="AFZ53775"/>
        <property type="gene ID" value="Cyan10605_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1670"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1772"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035655_0_0_3"/>
    <dbReference type="OMA" id="WGTIGNP"/>
    <dbReference type="OrthoDB" id="1178434at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021763">
        <property type="entry name" value="DUF3326"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36891">
        <property type="entry name" value="PTHR36891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11805">
        <property type="entry name" value="DUF3326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="353" mass="38188" checksum="511FD1C71D3B5BFC" modified="2013-03-06" version="1">MTNNKPYSTVLIIPTGIGADIGGYAGDALPIARAIAQGCDRLITHPNVMNGANLYWSTDNIYYVEGYALDQFASAKWGLQPVRQNNIGIIFDQSIETELFYRHIQTIDAVRATLGIEINEYIITDEPLGVELRIADSGASWGTIKNPDSLLRAGEKLIKERKVNALAVIARFPDDNDSQALQNYRYGEGVDALAGAEAVISHLLVREFQIPSAHAPALSPLPLDINISPKAAAEELGFTFLPCVLVGLSRAPQYTLTKDNYSFWAEDVNCLIVPANACGGSATLSFSGLNTLIIAVKENSTVLDVTPEKLGLNVVTVNSYLEAIGVMVAHRGGISLQALKPKINSIFTKKSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F7</accession>
    <name>K9Z5F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRC-barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219360.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1524"/>
    <dbReference type="EnsemblBacteria" id="AFZ53633">
        <property type="protein sequence ID" value="AFZ53633"/>
        <property type="gene ID" value="Cyan10605_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1524"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1619"/>
    <dbReference type="eggNOG" id="COG1873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        </location>
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            <begin position="300"/>
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    </feature>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="322" mass="36924" checksum="8364543509F7F7C1" modified="2013-03-06" version="1">MIDAQSSLRNEFLNTQVITRNTGKRLGVVKEVLVDVDRREVVALGLRDNRLAMSGIPKYMYLDRISQMGDVVLVEDEDVIEDVDIDLYSALINSEVVTETGEPLGKVRDFQFNQENGQLNSLIIAAIGLPQIPEQLISTYEISVDEIVSSGPNRIIVFEGAEERVTQITVGLLERLGIGRPPWEKDEDEMYYAPTTPPENQLPTGVPMRPVAQPKPQRTAVVEENWTEDEWEQAEVITPPPARRQEAMAYQEEIEEDNWGESGVEREPAPRYQLNNYDKSETRSKYDESLEDDMWDDDVEDDYRPQKVNIPQKQKMPEYEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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                <person name="Rippka R."/>
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                <person name="Sivonen K."/>
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                <person name="Goodwin L."/>
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                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">PCC 10605</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="765" mass="86380" checksum="EE808D13913BFCA0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U9</accession>
    <name>K9Z5U9_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="AFZ54117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="33030" checksum="E09774D4AA5D9B3B" modified="2013-03-06" version="1">MIKTKKLGILTIHGMGETESTFSCELENLLKIRLKKLSVDVEKEIHFESIYYQPVLQDNQYNIWNKMQCEPSEKLRWLQLRKFFLFAFSDAVSLEHKPKEENSVYKQTQKIIVESLRSTKNNLQNSQCPLIVIAQSLGCQVISNYIWDSQKEDKDETIWDENSSDYINPHDDEIDFLKLKTMKFLFTSGCNIPIFVAGFDSIQAFKKPNSEFQWKNYYDKDDCLGWPLQPLSEDYNKLVEDFEIDTGNVFSSWTPLSHGQYWTDRDFVNPIVDAINEILKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z4</accession>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1897</name>
    </gene>
    <organism evidence="7 8">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFZ53995.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.2013"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="207"/>
            <end position="224"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
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            <end position="295"/>
        </location>
    </feature>
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            <end position="327"/>
        </location>
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            <end position="352"/>
        </location>
    </feature>
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            <end position="381"/>
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            <begin position="402"/>
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            <begin position="470"/>
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        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="501" mass="54759" checksum="719A787F9D6618F7" modified="2013-03-06" version="1">MTKIETWEDTGQGYPLRWWVLPIVCLPTLAMLLDGNIVFIALPAIGDTFRDFPNLGEWVLASFSLVAAALSLPAGELGDRIGLRKVFSWGLWLFILGSGICFFAFKGWILILGRVICACGAAILAPVALACLRRIFPPKEQAIAFGYWSASVTIGTVIGPFLGGFLEHIASWHWVFFAPVVPAAIGLLGLPLLPLLPAKQISFKPDYIGITTIGFAIFFFLFFLMESPNLSPSLNILIICLFLLTVVMWRQSANKPSAVIPLNIITRNSWYVPSVLQLFIRALFVFVMTCLTVYFQEGRSLSALDTSIHILPLSILSGVVSLASGYLEKSFGVKYLMMATLTLTALGFWSLRDIPLSGFDGGDWFGIVAFGILYGNTAQLSHQALVHFSKSQAMRGSAINTLTINLGLALGAAIYSIFISIALPLNLKQQSNWQFPVEIPSSVQEILNQVDQNLHTSSHSQSLQALQESLAHSFGFGFALCAISCLIAIAITYSMRPFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z610</accession>
    <name>K9Z610_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
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            <taxon>Cyanobacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="456" mass="51802" checksum="16810D608934BB3F" modified="2013-03-06" version="1">MKIIVDEQNTVYELDQKLGEGGQGRVYSIKGGRKAIKLIPDKSTVRRDRLRRQLSQVRMLFDIQQLPIAMPLEMLQPPHVGYVMELLTGMIPISKLTYLPQKIECPVTWYLQGGGLRRRLILLAKSAEALSQLHGRGLVYADPSPNNIFVSSDLDANEIRFIDADNLCYESNVSSSFYTPGYGAPELVKGKSGVNTLTDAHAFAVIAFQILTTLHPLTDGDLVSYGEPELEEKALQGEIPWIDNPNDNSNYTDKGFPRDITLSPRLQTLANKCFGEGLLNPQKRPGLNQWAEYLYNAADFTITCPSCHSTYYANQKDCSWCEYPRPDLVIVEIYRWHPDEKPEKKGKLLQVMALQRDSSVILTNRIINGRLGIDAHQPNLEIEFTDHYLRVHKCNNQTFLLTSQNQENNKIEREISEDRWLKFPVEAGKYGDWLLHFGSLSCPHRYASFRLIKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z644</accession>
    <name>K9Z644_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54187">
        <property type="protein sequence ID" value="AFZ54187"/>
        <property type="gene ID" value="Cyan10605_2098"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="FISECGN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="34863" checksum="AB2CBE9B85E67427" modified="2013-03-06" version="1">MLSFQSKQEIPESTIQLYTNSFGQLKNIAVIARTIDKEKFTSKEFINFLMLNRQFESNAGAYEGLRNSIELLRVALETKESFLKIEATETRYRSFSQQEFYDYVYNLLVKDMEVTEFQEAVQKQLVRVIPKIKSDEGKAAIQSYVNHLETVCKDKLGLKLLYLFKQYDMSNFSLLRTVGEIADSFYDKDLDSLKEFMVVVQVNADIFLKLGQIIQVPQKKNVPETYAITLQYIALRNRHQNSFAQFQQLLGLLRQWENFYNPIIAIAKEYPPSEYKQPDIFKADIPGLEIYNKYQTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z646</accession>
    <name>K9Z646_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54661">
        <property type="protein sequence ID" value="AFZ54661"/>
        <property type="gene ID" value="Cyan10605_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2584"/>
    <dbReference type="HOGENOM" id="CLU_2478120_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10386" checksum="D15CBDF65A391F24" modified="2013-03-06" version="1">MFIIVLAELLDFTLIERYFSYRLQTETEIKISENNNFSSVLYKPYFDCYQEFNNWQLEQVESQKKSKNLNLISFACSKGDILSLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z679</accession>
    <name>K9Z679_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">Cyan10605_2571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220372.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2571"/>
    <dbReference type="EnsemblBacteria" id="AFZ54649">
        <property type="protein sequence ID" value="AFZ54649"/>
        <property type="gene ID" value="Cyan10605_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2571"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2731"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_3"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="19203" checksum="CBA959FF6A4241EB" modified="2013-03-06" version="1">MDLSRIPAQPKQGIINVLIEIPGGSKNKYEFDKDMNAFILDRVLFSSVKYPYDYGFVPNTLADDGDPLDGMVMMDEPTFPGCVIAARPVCMLEMIDGGDRDEKILCVPAEDPRYDHVKSLKDIAPHRLEEIAEFFRSYKNLEKKETQILGWKDIDQVAPLVEQCVKAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D0</accession>
    <name>K9Z6D0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220027.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2216"/>
    <dbReference type="EnsemblBacteria" id="AFZ54302">
        <property type="protein sequence ID" value="AFZ54302"/>
        <property type="gene ID" value="Cyan10605_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2216"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085045_0_0_3"/>
    <dbReference type="OMA" id="LYAQADP"/>
    <dbReference type="OrthoDB" id="1955920at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22029" checksum="03F6106E0E84806A" modified="2013-03-06" version="1" precursor="true">MNLNRNTIILFITAFSLMGLVFLTEIRKDGFNISPVGKQEDNIPSIFPFKTEEIQALEIQIDDQFIAFEKTGNEPLSWMMKQPENTKASDAAIAFLLNLFPSANKKIELLATDEQRKEYGINNNSPTITITLKNSDRYQMILGKSNFDDTQIYAEVIFPEKEKIKPQIYLVSKSFQYALERNFDEWLEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I3</accession>
    <name>K9Z6I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220457.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2660"/>
    <dbReference type="EnsemblBacteria" id="AFZ54734">
        <property type="protein sequence ID" value="AFZ54734"/>
        <property type="gene ID" value="Cyan10605_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2660"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_3"/>
    <dbReference type="OMA" id="EEYICCI"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="17381" checksum="12C640A773A8A465" modified="2013-03-06" version="1">MLDERIILRKFQKQKEYLVNLKVYENLDYETFINDQVIQLAIERLLQLTIEVALDVNRYLFKSLRIKQPEENAESFIKLAQLKILDDDLALRLKESGKMRNLLVHLYEIIEPPFVHSAIKETLRDYPLYQRQILNYLDTLNTLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6P9</accession>
    <name>K9Z6P9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase HEAT domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219950.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2137"/>
    <dbReference type="EnsemblBacteria" id="AFZ54225">
        <property type="protein sequence ID" value="AFZ54225"/>
        <property type="gene ID" value="Cyan10605_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2137"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2272"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101012_0_0_3"/>
    <dbReference type="OMA" id="WLVQFSI"/>
    <dbReference type="OrthoDB" id="1791822at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24059" checksum="2B50230137247BE0" modified="2013-03-06" version="1">MTITPESVKQLLYSDNFGDRIKGINELKKLGSAIAFSLIQPILKDENVRVRYAAVSQLDSIGDANREESLELLLDTLYNDPEADVRAAAADAIAGLKLQEAFPDLKKVYQETNDWLIQFSIIAALGELGHPEGFDILSEALAGDNSLLQTTAISALGELGDKRAIDLLLPFVNNEDWQIRHRLAQALGKLGGDKAQEILQKLSQDELDIVAQEAKTYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q4</accession>
    <name>K9Z6Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220537.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2744"/>
    <dbReference type="EnsemblBacteria" id="AFZ54814">
        <property type="protein sequence ID" value="AFZ54814"/>
        <property type="gene ID" value="Cyan10605_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2744"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529734_0_0_3"/>
    <dbReference type="OMA" id="SITAKEM"/>
    <dbReference type="OrthoDB" id="1489549at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="55124" checksum="658A13DA7E224C26" modified="2013-03-06" version="1">MNLPLEIINQITEKHISFINTRNQLNLPPYQGNFPFRVKQKEAIELGLSNFPLVIIVGNPASGKTEIAKAILDTAIKNHNSTLIISLHQSSLNQYQNLSLKPLQINQEIEYYETVKNWLKSKIQNPEINFTPPYLLPDTLFDNLEINIQKLSELITETNQEKLRKRIKQKFPQISDSRCMLLMAKIKKFSHLLIQREYLKQNYQNLADNDLEELTQLTINTVSFPHTCLISDIDLMPDKIFDIVIIENSHLLTQNVIEIIAKNSQKLILLGELDTDRDNFLKRLFYDLSPAYRLEIKENHRLTIDLARKIFPLFYNDYPYTPVSHSLNIPRKTGNLPVLVEKNYLIWHDIVNFQQMIIVLKQYLLENKDYQILTFSQKTSTLIQQLLDSNLNNQIIKSISNWYGEETENLLIVVDKNNQDNPTLTELKLALTRAKYSITILGDKTYYENSNLNILLQDNTITIKRDLALKSATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S0</accession>
    <name>K9Z6S0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ordered locus">Cyan10605_2766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2766"/>
    <dbReference type="EnsemblBacteria" id="AFZ54834">
        <property type="protein sequence ID" value="AFZ54834"/>
        <property type="gene ID" value="Cyan10605_2766"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2766"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2937"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_3"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="47412" checksum="8ED1770E18E809BC" modified="2013-03-06" version="1">MPPSDSMDLLTIATQAKTSAHHLATLSESARNTALNAIASALTERKEEIVKANEKDCSLAENNISSALYARLKLGESKLQSAIAGVRDVAKLRDPLGSISLKRELDQNLVLERVSCPLGVLGVIFEARPEALIQIASLAIKSGNGVILKGGKEALHTCTVLTEIIQKALQETEVNPYTVQLLTTREEIKALLDLDEYVDLIIPRGSNEFVRYVQENTKIPVLGHADGICHLFIDEFADLQPAVKITVDAKTQYPAACNAIETLLIHEKIASQFLPAIAQALEEKGVKLKGDEATRKIIDCEKAVEDDWRTEYSDLILALKIVDSIEDAIAHINKYGSKHTDGIVTTNLDNAEKFLNEVDSAGVYHNCSTRFADGFRYGFGAEVGISTQKMPPRGPVGLEGLVTYKYKLRGQGQIAADYSGINAKPFTHKDLDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T6</accession>
    <name>K9Z6T6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219833.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2014"/>
    <dbReference type="EnsemblBacteria" id="AFZ54108">
        <property type="protein sequence ID" value="AFZ54108"/>
        <property type="gene ID" value="Cyan10605_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2014"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="TTHEMQT"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="37983" checksum="9865F54759662ED9" modified="2013-03-06" version="1">MTIKFDNHELKKLSQQYTSTINPNLIKDKCDRTYLAPEWLGKGYKREIVLRNGISLIIHNYQLFENVIIDNRENIDETLEIAFKLSLPQYIPPNINISVKDGFCYVIGKNNEGDIWQELANIPSKAVDIHLNESLVESLINDYDDSLPQSLKPFFLGNNNLPVSLPQIISPQMKMVISQIINCSFQGITKQIYLEAKTLELLALKINSLRQIEQVKQIKIKLKKEDIEAIYHAEKIIVDNYNNPPSLIELSRQVGINTRKLKEGFRQIFHTTVFDYLYHYRMNLAQNLLKKQKNVGVVAQTIGYASATSFNAAFQKQFGVTPKLFQLAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T8</accession>
    <name>K9Z6T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220181.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z6T8"/>
    <dbReference type="STRING" id="755178.Cyan10605_2374"/>
    <dbReference type="EnsemblBacteria" id="AFZ54457">
        <property type="protein sequence ID" value="AFZ54457"/>
        <property type="gene ID" value="Cyan10605_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2374"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2521"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_2_3"/>
    <dbReference type="OMA" id="HLQNWRF"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="23263" checksum="4F805C8249D18760" modified="2013-03-06" version="1">MNTLEAIYQRRSVKAFDPNHKITPEEEKQLLEATIQAPTSFNIQHWRFVILRDPQLRQKIRQEYGNNQAQMTDASLLILFTADVKAWEKNPSRYWQNAPKEVADLLVNWIAPFHEGREWLQRDEAQRSIGMAMQNLMLAAKEMGYDSCPMIGFDIEKVAELVNLPKDYVIGPMVAIGKKIKEPWPKPGQIPLEDLIVENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U7</accession>
    <name>K9Z6U7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220191.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2384"/>
    <dbReference type="EnsemblBacteria" id="AFZ54467">
        <property type="protein sequence ID" value="AFZ54467"/>
        <property type="gene ID" value="Cyan10605_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2384"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2530"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100183_0_0_3"/>
    <dbReference type="OMA" id="SYDLHDK"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24946" checksum="994492C5A234A5DF" modified="2013-03-06" version="1">MNTKIIPPMENGDRLNSIEFEKLSHTIPENVKTELINGVVYMAATLRYEGHGLPHSLIITWLGFYMANTPGVELADKATVRLDLDNQPQPDALLRIKKGGQSRVSKDDYIEGAPELIVEIAGSTASYDLHDKLQVYRRHGVKEYIVWQVYSRKIDWFYLHEGKYLTFEPDGEGLIESKVFPGLVLAVNSLLEYNLAKVLSILQKQLNSEKHSFFIQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V3</accession>
    <name>K9Z6V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane transport energization protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219848.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2032"/>
    <dbReference type="EnsemblBacteria" id="AFZ54123">
        <property type="protein sequence ID" value="AFZ54123"/>
        <property type="gene ID" value="Cyan10605_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2032"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2159"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_3_0_3"/>
    <dbReference type="OMA" id="AYIGYNH"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="71"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="24093" checksum="E65AB9D845997798" modified="2013-03-06" version="1">MSTIELLKAGGIVSIPLLVFSVITIALIIERFWFWLRIKSRERVLVKEVLKIYPSDCVTVINKLRKNLDLPIARIFLESLELENANATEFRLALETATQAELPLLKRFNTFFQTVITVAPLLGLLGTILGLIQSFASLDLGNTGGTNTAGVTGGISEALVSTVMGLVVAIVTLMFANVFRSFYLRQIALIQEYGGQLELLYRRFYEKGGEEKAYANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V4</accession>
    <name>K9Z6V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220591.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2802"/>
    <dbReference type="EnsemblBacteria" id="AFZ54869">
        <property type="protein sequence ID" value="AFZ54869"/>
        <property type="gene ID" value="Cyan10605_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2802"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_30_3"/>
    <dbReference type="OMA" id="HESEIWA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="100" mass="11255" checksum="000B3118EC50AEB6" modified="2013-03-06" version="1">MIRLWNTETGELINTLMGHSFWIESLAFNPQGMILVSSSNDKTIKFWNYISGECIRTITQKDSWISAIPKGSASQHAFNRDGSLLVTGSNNGIIKVWQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y0</accession>
    <name>K9Z6Y0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220045.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2234"/>
    <dbReference type="EnsemblBacteria" id="AFZ54320">
        <property type="protein sequence ID" value="AFZ54320"/>
        <property type="gene ID" value="Cyan10605_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2234"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052332_0_0_3"/>
    <dbReference type="OMA" id="EYAYLDC"/>
    <dbReference type="OrthoDB" id="1462689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="307" mass="36513" checksum="AA21D45D56756228" modified="2013-03-06" version="1">MVYLTEVEEIKEIILDLTDTDILWLDTEVADYQTSHPRLSLIQVLAYPQDTRGDPEGICYAARTYIIDVLEKPEIIEFFIDYIMVNENIKKVFHNANYDLRFFDKKRAKNIFCTYQFARKIPYYLLPVKRYNLKYLTEYLTDFKVDKQEQSGDWGIRPLSTNQLEYAKKDCVYLAQVYYKLTEISKQLEYDPQTENIENLLERYEEIEDIYLRLTSEIGFLKERIKQSMISQNIKENKCFKIQSTSKKTIKADLQELVKLIKEKQVNINFPITLTKAIQEKLGNNLKEIEIQSETSQYYSLKEKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z703</accession>
    <name>K9Z703_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220245.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2441"/>
    <dbReference type="EnsemblBacteria" id="AFZ54522">
        <property type="protein sequence ID" value="AFZ54522"/>
        <property type="gene ID" value="Cyan10605_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2441"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2586"/>
    <dbReference type="eggNOG" id="ENOG5031Q1V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738627_0_0_3"/>
    <dbReference type="OMA" id="APCIVNT"/>
    <dbReference type="OrthoDB" id="1530368at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="17011" checksum="BB894A27CBC0EAD6" modified="2013-03-06" version="1">MNHQPNYRQLPAPCIIETGMLVNKEDMKRLINDLTQVRYLHSIDGVIQNQGQGWILEVFNDPNQATVVVNNSLYINVQSFDYLQLNQVSPQETHFDLVQDNRILKLIPFVNTSQEQQVSKNLGFDSLEEMLGEVFSAKWDVQLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B1</accession>
    <name>K9Z7B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIID/LytB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219983.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2172"/>
    <dbReference type="EnsemblBacteria" id="AFZ54258">
        <property type="protein sequence ID" value="AFZ54258"/>
        <property type="gene ID" value="Cyan10605_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2172"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2308"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021203_3_3_3"/>
    <dbReference type="OMA" id="LCQWGAK"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938622" evidence="1">
        <location>
            <begin position="30"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="40770" checksum="B34FE140C6BFB6CF" modified="2013-03-06" version="1" precursor="true">MSKKLILQWLGKFSLLSLLWLIFSPSAQAALELRVAIKKGANSLQVGSSTPAVVKDNAGRVVGQVAGMNSFVSKVQGGNVNLSQWKSNRLWLEPSGDGVVWIGDRWYRGRVLLVPQGKGITAINYVDLEDYLYSVVGAEAIPSWPKDALKAQAVAARTYALYKRNSGRNQIFDLDTTTATQVYKGLSSEYTTTHQAVRETMGEVMTYNNQIILAVFHSSSGGHTENVEDIWVSPLPYLRGVVDYDQNSPVFSWNKSVSPSTMNRIVGGVGNIQALIPQKTTPQGRIVTMKIVGDRTTKNVAGSDLRKALDLRSTLFRVSLGGNSLQVSGRGFGHGLGLSQWGAQYLAQNGVNYRQILAHYYRNAKLSTLKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C2</accession>
    <name>K9Z7C2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate 1-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220815.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3039"/>
    <dbReference type="EnsemblBacteria" id="AFZ55096">
        <property type="protein sequence ID" value="AFZ55096"/>
        <property type="gene ID" value="Cyan10605_3039"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3039"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3235"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_3"/>
    <dbReference type="OMA" id="SVWAIFD"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018658">
        <property type="term" value="F:salicylate 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="402" mass="46154" checksum="AA65553687B0D21D" modified="2013-03-06" version="1">MEKEIIIIGGGIGGLTLARALQLKRIDFQLYEQAKSFEALGYGLQISPNVVRVFQQLGLDKELEAISHRCYGFQLKSFDSDREIASWQLNQTIPYYQCRRADLHQLLYDSIEDKSRIHFCQRLTDYHQEEESLYFSLENDPQKYSAKALIGADGVRSHLRKSLFPNYEAKYSGYFAFRAILPFSEKYRPLWGKATVWMGKNHHVVAYPNENKQIGKCWLNLVLVVREKNWQEEGWAITADKQEIWQRFGNKSPLLDEILQDLGKTEETCYKWGLFTHQPLPYWSKGKVTLLGDAAHPMLPFQAQGAGMAIEDAYVLANCLSLETKIETALFKYQQLRQERATKVQQTSRKNADIFHATGISAIARDIALGLAVTVNSNLINLKTAWIYDYDVTNLGYISKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I1</accession>
    <name>K9Z7I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220823.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3047"/>
    <dbReference type="EnsemblBacteria" id="AFZ55104">
        <property type="protein sequence ID" value="AFZ55104"/>
        <property type="gene ID" value="Cyan10605_3047"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3047"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3244"/>
    <dbReference type="eggNOG" id="ENOG502Z8UG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089144_2_0_3"/>
    <dbReference type="OMA" id="SKTDEYC"/>
    <dbReference type="OrthoDB" id="1143930at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021722">
        <property type="entry name" value="UPF_YvbH_oligomer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11724">
        <property type="entry name" value="YvbH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="YvbH_ext" evidence="2">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="23390" checksum="D6DD134289E74E84" modified="2013-03-06" version="1">MFKKVASDVLGLSDIGQVISPKDYDKVASDDYVLHEDGEKIYFLIKSQSDEYCFTNYALIHLDGTSATSKKRLLKRYSYKNNHFSDIKLETAGTVDLDIEIKFNLGSNSYSIDVRKQDIEYLKDLYKSLIKISSIQKENALYLELAEKSLNIASNVLTPYHQESTEQQFKAINSYTFNWLRKTHQAFNKKDFSDVFLMFINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J2</accession>
    <name>K9Z7J2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220273.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2469"/>
    <dbReference type="EnsemblBacteria" id="AFZ54550">
        <property type="protein sequence ID" value="AFZ54550"/>
        <property type="gene ID" value="Cyan10605_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2469"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2616"/>
    <dbReference type="eggNOG" id="ENOG5033C19">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186876_1_0_3"/>
    <dbReference type="OMA" id="WESPRKM"/>
    <dbReference type="OrthoDB" id="2089526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7407" checksum="5A2E55F70D9AC3C2" modified="2013-03-06" version="1">MSRLKSWESPRRQGRNDKGKGGSARKRQLKKRLQMLRNQLKNKGGESHLFLFLCLTEFIKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L4</accession>
    <name>K9Z7L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2494"/>
    <dbReference type="EnsemblBacteria" id="AFZ54575">
        <property type="protein sequence ID" value="AFZ54575"/>
        <property type="gene ID" value="Cyan10605_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2494"/>
    <dbReference type="eggNOG" id="ENOG502ZAU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396799_0_0_3"/>
    <dbReference type="OMA" id="RTYLKME"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="715" mass="84054" checksum="73A5821BB2F89187" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q2</accession>
    <name>K9Z7Q2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">Cyan10605_2344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220152.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2344"/>
    <dbReference type="EnsemblBacteria" id="AFZ54428">
        <property type="protein sequence ID" value="AFZ54428"/>
        <property type="gene ID" value="Cyan10605_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2344"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2488"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_1_1_3"/>
    <dbReference type="OMA" id="CDLILIM"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="231" mass="25082" checksum="7E2E3A9CEC1955FE" modified="2013-03-06" version="1">MSDKKVVISPSILSADFSRLGEEIKAVDEAGADWIHVDVMDGRFVPNITIGPLIVEAIRPYTKKPLDVHLMIVEPEKYVEDFAKAGADIISVHAEHNASPHLHRTLCQIRELGKQSGVVLNPSTPLELIEYVIDVCDLVLIMSVNPGFGGQSFIPSVVPKIKALRQMCDEKGLDPWIEVDGGLKPNNTWQVLEAGANAIVAGSAVFKAPSYADAIEGIRNSKRPEPELATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W4</accession>
    <name>K9Z7W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2406"/>
    <dbReference type="EnsemblBacteria" id="AFZ54488">
        <property type="protein sequence ID" value="AFZ54488"/>
        <property type="gene ID" value="Cyan10605_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2406"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2552"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126608_0_0_3"/>
    <dbReference type="OMA" id="GCINGIN"/>
    <dbReference type="OrthoDB" id="1750956at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="21955" checksum="9A256BC6E21819BA" modified="2013-03-06" version="1">MLNEIIYQEIERIAKEKGIEISLLKEFANFVIVNQKTKTSKKKVGKTKGKKPLSMTAIKKAVLDYFHVKDTKDLRKSSEFKLATESMDLNFRQKESWETLYREFVGILPEEEGEEGVNCINGINIFKYFRPWRVFGLNPKTATEKEIKSAYRKLSKKYHPDNPETGNAQIFDRINTMYQSILPKTYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z843</accession>
    <name>K9Z843_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220458.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2661"/>
    <dbReference type="EnsemblBacteria" id="AFZ54735">
        <property type="protein sequence ID" value="AFZ54735"/>
        <property type="gene ID" value="Cyan10605_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2661"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2826"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739690_0_0_3"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="15364" checksum="1CF3853A1907B96E" modified="2013-03-06" version="1">MNKQISIEHLQLLSRQIRKKIPYIKMLVLFGSRARGDIHDKSDWNFAVFYDEKKRKKYSKNKSFSYFEVSSILENLFQINAPIDVVDLNNCSARIADRVATEGILIYEIEERLFNNFKEKSLLSDEQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z858</accession>
    <name>K9Z858_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="10">RNAP omega subunit</shortName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoZ</name>
        <name evidence="11" type="ordered locus">Cyan10605_2850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">In cyanobacteria the RNAP catalytic core is composed of 2 alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220639.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2850"/>
    <dbReference type="EnsemblBacteria" id="AFZ54917">
        <property type="protein sequence ID" value="AFZ54917"/>
        <property type="gene ID" value="Cyan10605_2850"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2850"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3029"/>
    <dbReference type="eggNOG" id="ENOG5032RMS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175526_0_0_3"/>
    <dbReference type="OMA" id="LRAIIEM"/>
    <dbReference type="OrthoDB" id="1959836at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8728" checksum="74FC0D3155A61214" modified="2013-03-06" version="1">MLKKNSFDSSQIMFRSDALLAAASNRYKITVGVAKRAKERRKQDMENVEEVMKPVLRAIIEMSDELTQPEIISELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z891</accession>
    <name>K9Z891_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Circadian clock protein KaiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Component of the kaiABC complex, at least composed of a kaiC homohexamer, a kaiB dimer and two kaiA dimers. The kaiABC complex also interacts with sasA.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The kaiA domain mediates the interaction with kaiC, the homodimerization, and is responsible for the clock oscillation function.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3319"/>
    <dbReference type="EnsemblBacteria" id="AFZ55364">
        <property type="protein sequence ID" value="AFZ55364"/>
        <property type="gene ID" value="Cyan10605_3319"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3319"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3533"/>
    <dbReference type="eggNOG" id="ENOG502Z8HQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911234_0_0_3"/>
    <dbReference type="OMA" id="HMNLMED"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011648">
        <property type="entry name" value="Circadian_clock_KaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020844">
        <property type="entry name" value="Circadian_clock_KaiA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020856">
        <property type="entry name" value="Circadian_clock_protein_KaiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017944">
        <property type="entry name" value="KaiA/RbsU_helical_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07688">
        <property type="entry name" value="KaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01247">
        <property type="entry name" value="KaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101215">
        <property type="entry name" value="SSF101215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51431">
        <property type="entry name" value="KAIA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51430">
        <property type="entry name" value="KAIA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiA N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="KaiA C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="37170" checksum="C38728597A7288AA" modified="2013-03-06" version="1">MISENPLSSRLSICIFAPETKIVHSLTELLSGDRYDLHILNSASELGGFVVNNKENLDCLIILKNDLSIPIINEFYEQGLILPVIILEPDNLETPSLIEHNSNPIPLELTTDTPIGNHTFHTAEVKLTLNRLNHINHYIDKAITQFLHLAPSCSITENPGNQNTHKKIEEKQNFLLLQQRRLAEKLKERLGYLGVYYKRNPSYFYRHLSQTEKEEFITQMSEQYRQIILDYFNQENEVNQAIDQFVNQAFFADLSVSQILEIHMELMDEFAQQLKLEGRNEDILLDYRLALIDIIAHLCEMYRRSIPKEDLPFDVLFTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A7</accession>
    <name>K9Z8A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220533.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2738"/>
    <dbReference type="EnsemblBacteria" id="AFZ54810">
        <property type="protein sequence ID" value="AFZ54810"/>
        <property type="gene ID" value="Cyan10605_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2738"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078484_0_1_3"/>
    <dbReference type="OMA" id="GAREYAD"/>
    <dbReference type="OrthoDB" id="1602369at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="25681" checksum="CFD89FB076FA8FAA" modified="2013-03-06" version="1" precursor="true">MTENSIVTQSNPNMSNNGTTPPQVEEMGFDLTGELDRLEDLILSGVRIPFISKTLIAEDVLLNQLDLIRINLPDCFEQATQILQQRQKILTDAQSYAQKIVENAQRKASQLLDESRIVQQAESQAYQIRRQVQQDCENLQQKTVAEVEQIRQKIQQDAVKIRQQAITEAEEIQNEADVYADQVLSRLERDLAQMLRIVSNGRQQVYQQKLTPSQKVSDNTNKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F3</accession>
    <name>K9Z8F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220726.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2945"/>
    <dbReference type="EnsemblBacteria" id="AFZ55007">
        <property type="protein sequence ID" value="AFZ55007"/>
        <property type="gene ID" value="Cyan10605_2945"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2945"/>
    <dbReference type="eggNOG" id="ENOG5033TPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766665_0_0_3"/>
    <dbReference type="OMA" id="LAGNGCH"/>
    <dbReference type="OrthoDB" id="1061091at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="361" mass="41753" checksum="F3894F4C5FF95C41" modified="2013-03-06" version="1">MTNKNDSSPTPIYYVSPTGKVHAQTCRYCQPDKDGWKTIDSLQTALEQEYQLCRLCCPSEEEIVKLQVKSDSQYKSTEERLTTKVSSDKNQETSETFSESSQDKTKDKAKDKLTKNKEENQPVNNKEKQTKEKKNKTNFSSEKNQKDKPPVEKKRYKILAGNGCHQAISEVRGMLIPPGEGEKSFHLILPDGTQLEATFKNSRILWLAHNKPELLGDHWFRGYPKMKDNKLVSLQIIAWDGTMPTNPKGEESWEFTGVWTLQKNITVQRSMMLEDVRKIAKETGFIKKFKYTFINSFDWVKNKKLWAGYVYKVLCKRKGDVLEIKKVIPYACPRIKPVPKTNNFKGKKPFNKNIKPSFHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I2</accession>
    <name>K9Z8I2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2828"/>
    <dbReference type="EnsemblBacteria" id="AFZ54895">
        <property type="protein sequence ID" value="AFZ54895"/>
        <property type="gene ID" value="Cyan10605_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2828"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3005"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046116_2_0_3"/>
    <dbReference type="OMA" id="VEHEENW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="56735" checksum="04C2F5230304DC99" modified="2013-03-06" version="1">MNKYNRLKNFRHDTYEMLVKSKDATFELMDSIMTRENARSLAQFSLSPFFQRQWCSTYEAAEDSRPNGKKLMKRYTQEIDTLEYTLLGIDHTQWECKDSPTMKDRGYQYSHSSLNSSVVGQGYSTIAWLPPLKEKGSWALPLRHERITSFETPLSKARWQLKQVCRELPENRRKLVVLDCEYGNGKFIQQTADIEISKLIRVRSNLCLYSKPDPYSGRGRPKKHGAKWKLNQCDDFPQSNKVLEMEDSSLGLIRISKWTELHFYNAPTQQLTLFKIERLKEKKTGSLHRPLWLIWVGEEFLSLEYIWSQYRRRFGLEHWYRFAKQRLHWTLPNFRTPDRCQRWSNLIVNITWQLWLSKDLVQEHHLPWQKPQQNLTPGRVALSMTSLLIEIGSPTLSPKSRGKSHGWNLKGEKETKLKFIPPLKNSNPKVKKGEKPNFEGIVNSIYFLRKLIFVSLLIVLQFFLSLNYSEIGVRLQVAGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I3</accession>
    <name>K9Z8I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221224.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3470"/>
    <dbReference type="EnsemblBacteria" id="AFZ55506">
        <property type="protein sequence ID" value="AFZ55506"/>
        <property type="gene ID" value="Cyan10605_3470"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3470"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3695"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2568121_0_0_3"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9049" checksum="04292A26E4C4D64A" modified="2013-03-06" version="1">MTTTFSPKIVTDTWIEASWGDFIEATANPDYQKGKCYYYKGRLRIEMSPVVNDHASDHSIINSAINLYAGLAGINLNGYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N3</accession>
    <name>K9Z8N3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">Cyan10605_3523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
            <plasmid evidence="12">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221273.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3523"/>
    <dbReference type="EnsemblBacteria" id="AFZ55556">
        <property type="protein sequence ID" value="AFZ55556"/>
        <property type="gene ID" value="Cyan10605_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3523"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_0_3"/>
    <dbReference type="OMA" id="FYPLSGH"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="93" mass="11088" checksum="9EEE2EC07AAC61B0" modified="2013-03-06" version="1">MLFYLICYDIPDDKRRKKIADILEGYGSRVQYSVFESVLNAKQYKELRKRLKKVFKENEDNLRFYPISAHTLKQMEIWGQSSELTNPPKSIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U6</accession>
    <name>K9Z8U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220739.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55020">
        <property type="protein sequence ID" value="AFZ55020"/>
        <property type="gene ID" value="Cyan10605_2958"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2958"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3148"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="KQTARFT"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="46061" checksum="CFA17FB2A3098B69" modified="2013-03-06" version="1">MKQRYNYRIYPTSQQEQLLAQLFGCCRVVYNDGVALCQQIYKEGGKKPSNSELQKLLITQAKKTEKREWLSKVSAIPLQQSLNDFNIAYQNFFNSCQGKRKGKKVKPPKFKSRKSNQSARFTRGGFKVGQHKIKLAKIGKVKIIWSRKLPNPPSSATVIKDSASRYFISFVVETIPEKLPDNGQSVGIDLGIETFATLSNGQKIKSSKPLKKYQRKLRRCQRNLSRKKKGSKRDEKARKRVAKVHRKIKDTRTDFLHKLSTDIIRENQTIVLEDLNVSAMVKNRKLSKAISDLGWGTFRTLLEAKSVMYGREFIVIDRWIPTSQVCSNCGFNGGKKELNIREWTCINCGVVHDRDINASKNILVAGGHSETLNGRGAGRKTSIKLAVGDEASTHREIRFKHLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z967</accession>
    <name>K9Z967_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220869.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55150">
        <property type="protein sequence ID" value="AFZ55150"/>
        <property type="gene ID" value="Cyan10605_3094"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3094"/>
    <dbReference type="eggNOG" id="ENOG50334NS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193729_0_0_3"/>
    <dbReference type="OrthoDB" id="2088321at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8046" checksum="BE1ABD35709F88B6" modified="2013-03-06" version="1">MALVHWDKSVLTLHLKEMMEDHQKGDRTALLGLGAIVMGTVFIPATVKLGKPLLKSMIKSSLYLSSSIKKNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z969</accession>
    <name>K9Z969_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="11" type="ordered locus">Cyan10605_3225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220990.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3225"/>
    <dbReference type="EnsemblBacteria" id="AFZ55272">
        <property type="protein sequence ID" value="AFZ55272"/>
        <property type="gene ID" value="Cyan10605_3225"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3225"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3438"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_3"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="225"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="600" mass="68633" checksum="D9348FD73480EA7A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z973</accession>
    <name>K9Z973_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220874.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3102"/>
    <dbReference type="EnsemblBacteria" id="AFZ55155">
        <property type="protein sequence ID" value="AFZ55155"/>
        <property type="gene ID" value="Cyan10605_3102"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3102"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3306"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_3"/>
    <dbReference type="OMA" id="GYDRRFM"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="276"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="478" mass="52921" checksum="F878EF612C6E53DA" modified="2013-03-06" version="1">MAFTVNPIKFGTDGWRGVIAADFTFERVAKLAPLSAHVLREYNPNSNLMIVGFDRRFLAEDFAKLAADSLQEAGFDVLLSDSFAPTPAFSWAAKEKNALGALVLTASHNPAKYLGLKVKGAFGGSVTEDVTQKIEALIPRDETITSSKEGNITLFDPWESYCQQLSSQVNVNIIRDAIASGKLKIFVDVMHGAASGGLRRLLGCDIEEINANRDPLFDGGAPEPLPRYISELFRRVKEDAKDNPHRLRMGLVFDGDCDRIAAIDGQGNFCSTQILIPVLIEHLAQRKGMKGEIVKTVSGSDLIPKIAQFMNIPISETAIGYKYIAERMLQNQVLVGGEESGGVGYSNHIPERDALLSALYVLEAVVESGKDISDLYNNLRQQVNFTSEYDRIDLPLKNLEQKNLLQQRLSDNPLTEIAGKKVIDCLAIDGYKYRLEDSSWLLIRFSGTEPLLRLYSEAPTLKIVQENLHWAKEWATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z976</accession>
    <name>K9Z976_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CopD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220995.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3231"/>
    <dbReference type="EnsemblBacteria" id="AFZ55277">
        <property type="protein sequence ID" value="AFZ55277"/>
        <property type="gene ID" value="Cyan10605_3231"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3231"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3445"/>
    <dbReference type="eggNOG" id="ENOG5032SW8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764660_0_0_3"/>
    <dbReference type="OMA" id="TIWTGGH"/>
    <dbReference type="OrthoDB" id="1736268at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="16585" checksum="5969406B7C5AA88F" modified="2013-03-06" version="1">MIFKILVLLHTLSATIWTGGHLILAIMVLPKALKKSEPELIENFEQNFETLGLISLATQILTGLGLTWIYFPQFQGLWNLDNFLSRYIMFKLGILLLTLALAIHARFFIIPNLSKETLNQLAYHIVGVTTLAVLFVVFGVGIRLGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A8</accession>
    <name>K9Z9A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220889.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55170">
        <property type="protein sequence ID" value="AFZ55170"/>
        <property type="gene ID" value="Cyan10605_3118"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3118"/>
    <dbReference type="eggNOG" id="ENOG50336KQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022197_0_0_3"/>
    <dbReference type="OMA" id="FKRICAR"/>
    <dbReference type="OrthoDB" id="2046615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28217" checksum="81D4B6BDF20B93C8" modified="2013-03-06" version="1" precursor="true">MRKYIQIVLWLGIASIFLSCNTRTVHEPPPSVELLATDANFSIGRRIVRIPLVAIASINFPRSKAAVLCENKSDEFCNLSLDEIREKQPIPISVKALDISVNDYSYLQDAQTDTYISMPELCPMLSQQWAKEICLNRGSPVFGEYLRSFTLMNSDYLKYADISWIGNTKKSAGELVRELELEIGQPQRVCPNEENGQPSSLCVATLKLDNDLLAVWIVTRSQGLRGLTKDSEAIQTLVELWTDDATDGNEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9I6</accession>
    <name>K9Z9I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220767.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2988"/>
    <dbReference type="EnsemblBacteria" id="AFZ55048">
        <property type="protein sequence ID" value="AFZ55048"/>
        <property type="gene ID" value="Cyan10605_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2988"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3182"/>
    <dbReference type="eggNOG" id="COG3038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083138_1_1_3"/>
    <dbReference type="OMA" id="WIRFWIQ"/>
    <dbReference type="OrthoDB" id="1860160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022051">
        <property type="entry name" value="DUF3611"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34548">
        <property type="entry name" value="PTHR34548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12263">
        <property type="entry name" value="DUF3611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="20855" checksum="98D842408DC188A9" modified="2013-03-06" version="1">MTRESQITQSLPPAIQKVSRNLQLWGFWSFWLQLVLGIISAVTLLFATPALFEAKENTRGIQFGIFSAFISVLLLTAAIVLAFRYGKIGRKIENRDPALRPKKSETIRLIRIGLIFNLVGMVFAIIGAETLVGLALAKLLTLAPQLISPNPQQFVNSLDLLIIQANTNTITAHFTGIVTSLILLDRISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9M7</accession>
    <name>K9Z9M7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221145.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3385"/>
    <dbReference type="ESTHER" id="cyaap-k9z9m7">
        <property type="family name" value="abh_upf00227"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55427">
        <property type="protein sequence ID" value="AFZ55427"/>
        <property type="gene ID" value="Cyan10605_3385"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3385"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3603"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090601_0_0_3"/>
    <dbReference type="OMA" id="YIYLHGF"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="224" mass="26088" checksum="960D5C2D0DDE5E6C" modified="2013-03-06" version="1">MSNYLHLYLHGFASSPNSTKALYFQQRYQEINTPLAIMDFNQPDFTNLSLSRQINQVTKVITEKQESWEGQKIHPQFILIGSSFGGLTASWVAHNNPDKIKALILLAPAFNFALHLKNLQTQEAFIQWQKDGFFSIYHYGYKQQMSLNYNFWTDLLSYDESLINHSIPTLIFHGINDETIPIQSSRDYLKKHNNATLIELNSDHSLNNCLDNIWQELQLFWKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA34</accession>
    <name>K9ZA34_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221173.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3413"/>
    <dbReference type="EnsemblBacteria" id="AFZ55455">
        <property type="protein sequence ID" value="AFZ55455"/>
        <property type="gene ID" value="Cyan10605_3413"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3413"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3637"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059541_0_0_3"/>
    <dbReference type="OMA" id="ENIPRLW"/>
    <dbReference type="OrthoDB" id="1374655at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="286" mass="32591" checksum="4CD52032590894B8" modified="2013-03-06" version="1">MSQFPHDEFVKEILPELYQNYGQVIPSADVSSERREVDILFIPDKPVPTTADTLGLLGKIAQNTCLIEVYRNPVKINQILDCIGKLISIKNNRLKEQKSQINLWIITPTISKRILNQFEAKFQENWNNGIYFLAPALNTGIIAVHQLPKIRETLWLRLFGREQIQLNAMAELESLPENYPNKKNILKSVYGLLKAIEANQNKLSIVDQKRQVLIMSLRAIVEEELAQREKKAIQRGIQQGIQQGEISGKLETVPLLVQLGMGVDEISTRLNLPLEMVKKAVNYQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA53</accession>
    <name>K9ZA53_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenite efflux ATP-binding protein ArsA</fullName>
            <ecNumber evidence="4">3.6.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220956.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3189"/>
    <dbReference type="EnsemblBacteria" id="AFZ55238">
        <property type="protein sequence ID" value="AFZ55238"/>
        <property type="gene ID" value="Cyan10605_3189"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3189"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3399"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_3"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="3">
        <location>
            <begin position="328"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="393" mass="44475" checksum="C47FF1E9B6B1BD4E" modified="2013-03-06" version="1">MRVILMTGKGGVGKTSVAAATGLKCAQMGHKTLVLSTDPAHSLADSFDMELGHEPKAIRENLWGAELDALMELEGNWGAVKRYITEVLQARGLDGVQAEELAILPGMDEIFGLVRMKRHYDEGDFDVLIIDSAPTGTALRLLSLPEVSGWYMRRFYKPFQSMSAALRPLFEPIFKPIAGFSLPSNEVMDAPYEFYQQIEALEKVLTDNAQTSVRLVTNPEKMVIKESLRAHAYLSLYNVSTDLVIANRIIPEEVEDPFFQKWKANQNIYKKEIYDNFHPLPVKEVPLYSEEMCGLQALERLRDTLYDTDEDPSKVYYQENTIRVVQENNNYSLELYLPGIPKQQIKLNKTGDELNVRIGNHRRNLVLPQALAALNPSGAKMEEDYLKIKFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD9</accession>
    <name>K9ZAD9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Photosystem I reaction center subunit II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 5-143</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PsaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221061.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="4/D/d=5-143"/>
    </dbReference>
    <dbReference type="SMR" id="K9ZAD9"/>
    <dbReference type="STRING" id="755178.Cyan10605_3297"/>
    <dbReference type="EnsemblBacteria" id="AFZ55343">
        <property type="protein sequence ID" value="AFZ55343"/>
        <property type="gene ID" value="Cyan10605_3297"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3297"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3512"/>
    <dbReference type="eggNOG" id="ENOG502ZBN6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150527_0_0_3"/>
    <dbReference type="OMA" id="HNPRRIG"/>
    <dbReference type="OrthoDB" id="1787472at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003685">
        <property type="entry name" value="PsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036579">
        <property type="entry name" value="PsaD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31982">
        <property type="entry name" value="PTHR31982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02531">
        <property type="entry name" value="PsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64234">
        <property type="entry name" value="SSF64234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="144" mass="16173" checksum="51F8A4C98A3E3B01" modified="2013-03-06" version="1">MSETIQLTGTMPKFGGSTGGLLSAADREEKYAITWTSKTEQVFEMPTGGAAIMNEGENLLYFARKEQCLALGTQLRTKFKPKIEDYKIYRIYPTGETQYLHPADGVFPEKVNEGREFHGKKDRNIGKNPEPVTLKFSGKTPYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAG8</accession>
    <name>K9ZAG8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221101.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3341"/>
    <dbReference type="EnsemblBacteria" id="AFZ55383">
        <property type="protein sequence ID" value="AFZ55383"/>
        <property type="gene ID" value="Cyan10605_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3341"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3558"/>
    <dbReference type="eggNOG" id="COG1675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163200_0_0_3"/>
    <dbReference type="OMA" id="FFGFRWW"/>
    <dbReference type="OrthoDB" id="1795580at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="14149" checksum="2BA4745F30168780" modified="2013-03-06" version="1" precursor="true">MKPNFNNRIINVNDSGLGCLLTIVIVSLLLGAVGLQWVVNSVLILIAFLIISPVIAFWGFRWWLKRNLVEDSCPVCNYTFTGFNNTDCRCPNCGESLRVESGKFTRETPPGTIDVKAVDVDVSGNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ11</accession>
    <name>K9YZ11_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Appr-1-p processing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217896.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0003"/>
    <dbReference type="EnsemblBacteria" id="AFZ52164">
        <property type="protein sequence ID" value="AFZ52164"/>
        <property type="gene ID" value="Cyan10605_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0003"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.4"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396767_0_0_3"/>
    <dbReference type="OMA" id="FAWINDQ"/>
    <dbReference type="OrthoDB" id="94229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034401">
        <property type="entry name" value="PARP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF89">
        <property type="entry name" value="PTHR14453:SF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="383"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="822" mass="95233" checksum="C849E309825DFF02" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ68</accession>
    <name>K9YZ68_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217926.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0033"/>
    <dbReference type="EnsemblBacteria" id="AFZ52194">
        <property type="protein sequence ID" value="AFZ52194"/>
        <property type="gene ID" value="Cyan10605_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0033"/>
    <dbReference type="HOGENOM" id="CLU_1871992_0_0_3"/>
    <dbReference type="OMA" id="AASEMEF"/>
    <dbReference type="OrthoDB" id="2066454at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939018" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="15541" checksum="E61BCCC7DCA76A06" modified="2013-03-06" version="1" precursor="true">MLSKFSRFLTIAALTTLTCVITHPSSAQPETSEMGEEIEIVTVPLTINQLVNEAFWENSGDFFEQASMGGQLNTIFGWRKFPQGSYPENNITEDGLLLYAILSDYFRQLQEREPIIRTRDLANPFDTSLRENPQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZA0</accession>
    <name>K9YZA0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217961.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0068"/>
    <dbReference type="EnsemblBacteria" id="AFZ52229">
        <property type="protein sequence ID" value="AFZ52229"/>
        <property type="gene ID" value="Cyan10605_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0068"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072762_0_0_3"/>
    <dbReference type="OMA" id="NGLGKYP"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="33842" checksum="F6EE3C3493964575" modified="2013-03-06" version="1">MLPVNQLFIKVFRQKWQLWAIAFFLFFTLTFIIQEQKTTQHKTLETKIKEIGKNSKIPKKSLNQTELKEIAKLVNVRVFANIDDHEIGGSGVIIGQRKNSYLVLTNNHVVDNKEINYQIQTHTGKIYKGEVIWQNNDNLIVDDLALLTFESQEQYQTINIKNNYIPKKNELILASGFPFQDNLKQSENIKYTFGNLSQVLPKPLIGGYQIGYTNNVHSGMSGGSILNLQGQLIGINGLGKYPPLGNPYIYQNGNDIPENQVKNMSNLSWGISSQSINKLISKVEQQKNIDFQIQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZE3</accession>
    <name>K9YZE3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LpqB, GerMN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218048.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0159"/>
    <dbReference type="EnsemblBacteria" id="AFZ52316">
        <property type="protein sequence ID" value="AFZ52316"/>
        <property type="gene ID" value="Cyan10605_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0159"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094596_0_0_3"/>
    <dbReference type="OMA" id="ATWWAVH"/>
    <dbReference type="OrthoDB" id="1981104at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="22707" checksum="05C21F39E37E0AB9" modified="2013-03-06" version="1" precursor="true">MAKDQKPNSFFSTKIIASIATTVLAVGTFAAWYAYSNLESKNQVSQPDDTAPTDVEVIPDNPANNQQQQVAIYLLDENLQLTPKNIPLTKEENPQSALTTAFNQLLSEEESQDSAIPSDTKLENLEVKEDGIHLNLSEEFTLGGGSESMISRLGQVIYTASSLDPNASVWISVEGQPLDVLGGEGLIIEQPITREIFVQSFASSNSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZF4</accession>
    <name>K9YZF4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">Cyan10605_0137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218026.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0137"/>
    <dbReference type="EnsemblBacteria" id="AFZ52294">
        <property type="protein sequence ID" value="AFZ52294"/>
        <property type="gene ID" value="Cyan10605_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0137"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.141"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_3"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="37786" checksum="CFC19C6F32B56CBE" modified="2013-03-06" version="1">MTKKRVLSGVQPTGNLHIGNYLGAIRNWVEIQPNYDNFFCVVDLHAITVPHDRTSLADNTYTIAALYLACGIDLNYSTIFVQSHVKAHTELTWLLNCVTPLNWLERMIQFKEKAIKQGENVSVGLLDYPVLMAADILLYDADQVPVGEDQKQHLELTRDIAIRVNDKFGSEDKPVFKVPEPMIKKEGARVMSLTDGTNKMSKSDPSELSRINLLDSPDEIRKKIKKCKTDPIMGLSFSEDRPECNNLLGLYSIFSGKSKDEVSDECGDMGWGKFKPLLTDTVIEALQPIQNKYAEIMADKTYLDSVLRDGREKAENVANATLKRVKDALGYLPPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZL3</accession>
    <name>K9YZL3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="8" type="synonym">rpl1</name>
        <name evidence="10" type="ordered locus">Cyan10605_0198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218086.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0198"/>
    <dbReference type="EnsemblBacteria" id="AFZ52354">
        <property type="protein sequence ID" value="AFZ52354"/>
        <property type="gene ID" value="Cyan10605_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0198"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.208"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_3"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="25673" checksum="0E14534B276FA3D0" modified="2013-03-06" version="1">MSKKLSRRFKEALAKVEAKAYEPLEALQLLKETATAKFDETAEVHIRLGIDPKYTDQQLRTTVSLPKGTGQTVRVAVITRGEKVKEASEGGADLVGDEDLIDEIQKGMMDFDVLIATPDMMPKIAKLGRVLGPKGLMPSPKGGTVTTDLVGAINEFKAGKLEFRADRSGIVHVMFGKASFSANDLLTNLKAIQETVDRNRPSGAKGRYWRTMFVSSSMGPSIEVDINSLRDMKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z002</accession>
    <name>K9Z002_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">Cyan10605_0392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218267.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0392"/>
    <dbReference type="EnsemblBacteria" id="AFZ52536">
        <property type="protein sequence ID" value="AFZ52536"/>
        <property type="gene ID" value="Cyan10605_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0392"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.415"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_3"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="237" mass="26561" checksum="86ED4A7C29911770" modified="2013-03-06" version="1">MTQIKIVADKNALVTSASDFIINKIKETIANKNICSIALAGGSTPKPIYQNIAQSDLPWDKIHVFWGDERYVPPTHPDSNEKMAREAWLNQVDIPAQNIYPMPTLGNNPMADASKYEQELKDFFGVANGFPSFDIILLGMGDDGHTASLFPHTNALKECDRLITVGNKEDNQRLTFTVPLINHAQWVIFLVSGKNKQEALKAVFDQESDSDQYPSKKIQPQGELIWFIDEDANSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z084</accession>
    <name>K9Z084_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver modulated diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218342.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0469"/>
    <dbReference type="EnsemblBacteria" id="AFZ52611">
        <property type="protein sequence ID" value="AFZ52611"/>
        <property type="gene ID" value="Cyan10605_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0469"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.497"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_3"/>
    <dbReference type="OMA" id="IRNDNSD"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="367"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="624" mass="71452" checksum="27AD42BE4D0990E5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L1</accession>
    <name>K9Z0L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218452.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0582"/>
    <dbReference type="EnsemblBacteria" id="AFZ52721">
        <property type="protein sequence ID" value="AFZ52721"/>
        <property type="gene ID" value="Cyan10605_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0582"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.614"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012834_0_0_3"/>
    <dbReference type="OMA" id="FHNPYNF"/>
    <dbReference type="OrthoDB" id="1328104at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023825">
        <property type="entry name" value="CRISPR-assoc_RAMP_BGP1436"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03986">
        <property type="entry name" value="TIGR03986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="760" mass="85808" checksum="B344AC12F1F7B860" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z155</accession>
    <name>K9Z155_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0761"/>
    <dbReference type="EnsemblBacteria" id="AFZ52894">
        <property type="protein sequence ID" value="AFZ52894"/>
        <property type="gene ID" value="Cyan10605_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0761"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.800"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_1_3"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="37577" checksum="0D0D91BC11DFD6B1" modified="2013-03-06" version="1">MALLEMKVTFKILRQKPDFSPKFQSYTIEVNKGNTILECLDKIKWELDGSLTFRKNCRNTICGSCAVKINGRSALACKENVGGEIEKNPLSKSQNIPEIVISPLNNLPVLKDLVVDMSNFWQDLEKIEPYVCTSSRNTPEKEFLQTPEERKLLEETGNCIMCGACYSECNAKEVNSLFVGPHALAKSYRLVDDSRDENRENRIEKYNNTEKGVWGCTRCYLCNEVCPMGVAPLDQISKIKGIILEKKDVNSSRAIRHRKVLVSLVKDGGWIDERKFGLMVVGNYFRDLRGLFSIAPLGLRLLTSGKFPLTFKSSEGTREVRALIELVQNDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A9</accession>
    <name>K9Z1A9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218680.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0816"/>
    <dbReference type="EnsemblBacteria" id="AFZ52949">
        <property type="protein sequence ID" value="AFZ52949"/>
        <property type="gene ID" value="Cyan10605_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0816"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.859"/>
    <dbReference type="eggNOG" id="COG4222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047242_0_0_3"/>
    <dbReference type="OMA" id="NDNGMSE"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="42567" checksum="8C55EED18166155E" modified="2013-03-06" version="1">MSISRTRFIGFILVLFFFLFPFYDLKSLAEVDRTFLDLKIEFLGEYTLKESNYKDTVIGGLSGITYNPKEDVYYLISDDRANISPARFYTVKINIEGEKIENIKIENVTFLRDKKGELYQENTTDTEGIAFSPHNSLFISSEGVTNKNIPAFINEYDLEGNLLNSVRIPERYIPKTGEKKGIENNLGLESLTIKANGFMPNDPFRLFTVTESALVQDVDLKNPLTVLRSRFLHYVINPFGDPVLIGEHLYTIDEPSFSTLYNGVADLLSLPDEGYLLSLERTFGLRGYGAKIFQLVIGNANDISGQKSISGNVENIIPIKKKLLLDLKQLGIKLDNLEGMTLGGRFPDGSQSLILVSDNNFSGNSKQKNQFLLFKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C1</accession>
    <name>K9Z1C1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0871"/>
    <dbReference type="EnsemblBacteria" id="AFZ53001">
        <property type="protein sequence ID" value="AFZ53001"/>
        <property type="gene ID" value="Cyan10605_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0871"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_1_0_3"/>
    <dbReference type="OMA" id="EGNSWRA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="140" mass="15614" checksum="B9DBE26B1A7B67DD" modified="2013-03-06" version="1">MSSPLVWLIIGCILCLMEFIFPTAFVELMMGLSAIIIAGLALIIPYNNLLIVLWMVLSVLLIYFAKKYLEPKKKDPLLLEGNEGITITAIEAGKTGRVMYEGSLWLAICSDETMKIPPDEKVFIVSREGNILSVLPRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D9</accession>
    <name>K9Z1D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LL-diaminopimelate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.83" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218278.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0403"/>
    <dbReference type="EnsemblBacteria" id="AFZ52547">
        <property type="protein sequence ID" value="AFZ52547"/>
        <property type="gene ID" value="Cyan10605_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0403"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.426"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_3"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="392" mass="43207" checksum="04CC1C06BBE9B6A3" modified="2013-03-06" version="1">MQLSDRLKPLEKNVFADMDRAKTEAISLGKNIIDLSLGSSDLGASEHIIKTIGESLHNSDNHGYLLHGGTANFRQVAANWYEKRFGVAVDWETEVLPLIGCQEGTAHLPLAIINQGDYALLLDPGYPSHAGGIYMAGGNIYPMPLLAENSFLPQFNEIPATILAKAKMMVLSYPHNPTTAIASLDFFDSAFRFCQANNLVLVHDFPYMDIVFDENKAPSILQADRKKEISIEFFTFSKSYNMGGFRIGFAIGNSQLIKALKQIKSVVDFNQYKGILEGAITALTSSQECVAETVKIYRERRDFLVKELNNIGWHTPTPLATLYLWAKLPEKWQKDSIAFCVNLVKETGVALSPGAGFGSCGEGYVRFALVKPPEVLKEAVNKIASFLGSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H4</accession>
    <name>K9Z1H4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0931"/>
    <dbReference type="EnsemblBacteria" id="AFZ53061">
        <property type="protein sequence ID" value="AFZ53061"/>
        <property type="gene ID" value="Cyan10605_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0931"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.979"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084696_0_0_3"/>
    <dbReference type="OMA" id="FFDPRKV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="91"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="30246" checksum="AA2DDA3EE73B7FCB" modified="2013-03-06" version="1">MHNFDINNDNLNLEGKYIENHLDFEDTTDLEEENLTEKEHPKPQLIPRPEYNPNYQVNSTNIITNSTEINHNYYENHTHNSHVNPHRLRDRISIFVDGNNMFYAQQKNGWFFDPRKVIDYFSEESGFMLINAFWYTGLKDSQDQRGFRDALISLGYTVRTKILKEYYDDSSGRFSQKANLDIEIVVDMFNTVDQYDRVVLFSGDGDFERAIELLRSKNTHITVVSTDGMIARELRNATDRYIDLNEIRNCIEKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N5</accession>
    <name>K9Z1N5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218805.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0944"/>
    <dbReference type="EnsemblBacteria" id="AFZ53074">
        <property type="protein sequence ID" value="AFZ53074"/>
        <property type="gene ID" value="Cyan10605_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0944"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.995"/>
    <dbReference type="eggNOG" id="COG0678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_2_0_3"/>
    <dbReference type="OMA" id="GYINHPK"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PTHR10430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="21501" checksum="CB29F1DE38BDE430" modified="2013-03-06" version="1">MAVLERVPDVVFKTRVRDESIQPNPYRWEDKTTQDIFGGKKVVVFSLPGAFTPTCSSNHLPRYEELYDEFKALGVDEIVCVSVNDAFVMFKWGREIGAKNVFLLPDGNGEFTRKMGMLVDKSNLGFGLRSWRYSMFVNDCKIEKIFVEPNFSDNCPTDPFEVSDADTMLAYLKGEQPKGVSEPRKEFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q8</accession>
    <name>K9Z1Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218825.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53094">
        <property type="protein sequence ID" value="AFZ53094"/>
        <property type="gene ID" value="Cyan10605_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0964"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_3_2_3"/>
    <dbReference type="OMA" id="MQFGIEI"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="62"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="39226" checksum="1712CD09A2F9128C" modified="2013-03-06" version="1" precursor="true">MIKILRFFIFGFFRWLIIVSTIFIFSSIALVTYIYQIEPQWIQIKNLDITLPNLEENFEGWRILQVSDIHINQWMTEERLTNIVNLINEQQPDIIVLTGDFFSQSGSYSTRLDRLEERIIPKIPYAEEHPSLIKRFLNKAGFPIQDTPRRRYFDDDQITLINSLSKLKPHYKSFAILGNHDYATSHKLVREGLKDSDIITLRNRVYTIENNSSYLNIIGVDDVLYGKDDLDSVLTQIPDKGANILLVHEPDFAVLAWKTHRFQLQLSGHSHGGQIKIPFRKPPFLPPYGQQFPEGLYRFSDLLLYTNRGVGMAYPYIRFNCRPEITIFTLHSAKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S2</accession>
    <name>K9Z1S2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="5" type="synonym">rpl10</name>
        <name evidence="7" type="ordered locus">Cyan10605_0156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0156"/>
    <dbReference type="EnsemblBacteria" id="AFZ52313">
        <property type="protein sequence ID" value="AFZ52313"/>
        <property type="gene ID" value="Cyan10605_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0156"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.162"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_1_3"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="19739" checksum="57E3AB5FFE59FC36" modified="2013-03-06" version="1">MRVISKSLESKKQEVTEIKQLLEKSRLAVVIDYQGLTVADITNLRNRLREGGTICKVTKNTLMGKAIEGDENWQPMTEFLKGSSAFILADEENIGSAVKAYQAFAKESKKTTLRGGVMEGKALSEAEVKALADLPTKEQLIAQIAGSINSITAKIAIGVKEVPASIARGIEAYRAKQEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W0</accession>
    <name>K9Z1W0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1023"/>
    <dbReference type="EnsemblBacteria" id="AFZ53149">
        <property type="protein sequence ID" value="AFZ53149"/>
        <property type="gene ID" value="Cyan10605_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1023"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1084"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_6_0_3"/>
    <dbReference type="OMA" id="HANTEAM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="22978" checksum="ACCA3F8F2194013A" modified="2013-03-06" version="1">MEKSTSRKKKKIQQEYPDADVQVWAEDEHRLGLKPVLRRVWVEKGYQPIATVNWRFQWLWLYGFVEPNTGETYWWLLPYVNTELFNRVLKDFAQHYEIGKNKRVILAMDQAGWHPIKETTEIPEGIHVMLMPSHSPELQPAERLWPLINEAIANRTFKNLEELEEVVISRCKKIMEEKEIVKGIANFYWWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X5</accession>
    <name>K9Z1X5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218443.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0571"/>
    <dbReference type="EnsemblBacteria" id="AFZ52712">
        <property type="protein sequence ID" value="AFZ52712"/>
        <property type="gene ID" value="Cyan10605_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0571"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.602"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_1_5_3"/>
    <dbReference type="OMA" id="ENKMANP"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="9895" checksum="B0273B45311A6954" modified="2013-03-06" version="1">MNVFGIGLPEMILIFVVALLIFGPKKLPEIGKSLGKTLKGFQEASKEFQEEFKKEAEKIEETVSMKAQLESSKETEENVVNSSSTEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z213</accession>
    <name>K9Z213_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218361.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0488"/>
    <dbReference type="REBASE" id="58412">
        <property type="entry name" value="Cap10605ORF487P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52630">
        <property type="protein sequence ID" value="AFZ52630"/>
        <property type="gene ID" value="Cyan10605_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0488"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.517"/>
    <dbReference type="eggNOG" id="ENOG502ZA78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730772_0_0_3"/>
    <dbReference type="OrthoDB" id="813533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="379" mass="44569" checksum="F4EB2FA5CFFB922F" modified="2013-03-06" version="1">MNNILKFKGVIKNVIYNPRLIQSLKLYSFQEFNINICDGFGLIQLEDKNIAYSKWVSPKRTRSYPFARMYNTYSQSKVITIIPIIKDEGKDGDLDKIGFTTFCWMNLLNIYIILGYYEDAEKSQKKGQISKDKLSEQKFNNNFIKQQIEKIFNYKQSALHWNKNLFENEFINIFNLALNCYKKIENKTGVKIHNQDRLREYLKDIQTDFEEFKNISLKFSQQAINREIQTEHNLEYLVDGCKGVFEIENDLGGIYHLTADEIIIDKQNYIIQESKNSSKKCLPSLDDIQDGLFKLILYSNLDHLYLEDQELQFSCRLKLTGNNIKEEILLSESTESQELEKFIENNIFILTNQEVGIIYKLLLEVKRNKKLNILITNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z241</accession>
    <name>K9Z241_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ordered locus">Cyan10605_0315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0315"/>
    <dbReference type="EnsemblBacteria" id="AFZ52463">
        <property type="protein sequence ID" value="AFZ52463"/>
        <property type="gene ID" value="Cyan10605_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0315"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.328"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_2_3"/>
    <dbReference type="OMA" id="FWEKHLW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="27756" checksum="C34CA479B9544EBC" modified="2013-03-06" version="1">MEEKQILPHHLELWQKTLNWTPSSSVLEKWQELYNQILIKNKYLNLTRITTVEEFWEKNLWDSLAPIIDYDLKNKKVIDIGTGGGFPGLACAIAFPESEFILMDSIAKKVNFIDETKQILNIENVITLINRAEIIGQDINHRNKYDFALIRAVAEISVCLEYTLPLLKQGGIAILYRGNIEQKEQEKIAKVAYKLGGELIEITNKNTPVNNYTRNNVYIKKITNTPKKYPREVGKPTKNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z270</accession>
    <name>K9Z270_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2281 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219025.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1175"/>
    <dbReference type="EnsemblBacteria" id="AFZ53296">
        <property type="protein sequence ID" value="AFZ53296"/>
        <property type="gene ID" value="Cyan10605_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1175"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1241"/>
    <dbReference type="eggNOG" id="ENOG5033GMF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_9_0_3"/>
    <dbReference type="OMA" id="WISDDFN"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018739">
        <property type="entry name" value="DUF2281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10047">
        <property type="entry name" value="DUF2281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2281" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9075" checksum="1916A1FA6614B722" modified="2013-03-06" version="1">MTTQTIDLPEMILTKIKDLPLEQQQEILDFTEFIAHKYTKNSGENNKSNGKRVAGLFKGKGWISDDFNEPLPPEILGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A4</accession>
    <name>K9Z2A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218254.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0378"/>
    <dbReference type="EnsemblBacteria" id="AFZ52523">
        <property type="protein sequence ID" value="AFZ52523"/>
        <property type="gene ID" value="Cyan10605_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0378"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.398"/>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_3"/>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="29150" checksum="FA876C97E2296BFD" modified="2013-03-06" version="1">MTVYFIGAGPGDPDLLTLKAYKILQSADVILYADSLVPKQILKDTKENAELIATGNKTLEEIIPLMIKKEKQGLTVVRLQSGDLCLYSAIHEQMRLLAEADIPFELIPGISAYQAAAAKIASELTIPDLVQTIILTRVSGKASQVPEKEELEKLAAHEASLCLYLAARHVEKSQEDLLKHYPADTPVAICYRVGWEDEKIIIVPLTKMAETTYDYGFIRTTLYLISPALKILPQQQSLKGESYQSRSKLYNPSHNHLFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J0</accession>
    <name>K9Z2J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218678.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0814"/>
    <dbReference type="EnsemblBacteria" id="AFZ52947">
        <property type="protein sequence ID" value="AFZ52947"/>
        <property type="gene ID" value="Cyan10605_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0814"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.857"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_1_2_3"/>
    <dbReference type="OMA" id="VKGPFND"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="183"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="427" mass="47715" checksum="AEFF75ABB8C65548" modified="2013-03-06" version="1">MGGNILAIFLSRTHGENNYRRKASGTRANRRNIKSKVAQTQTNKRLIRKTNAPYTSITQENIVTQAKEQQNLVNIILNNVFRLTIFGVGIGTIFGSVLANTDLTKPLFPKIDIPFVDRVAQNTSVNQETNSSQESKPLAYTPEVSSNPEELKFSEELTALRSKFDTLRAKYPQLEPGAFFVDLDNGAYVNYNGIAPFPAASTIKIPVLVAFLQDIDEGKIYLDEKLTMTEANRVPHSGNMQYQPLGTQFTALYTATEMIINSDNTATEMIIERLGGKDELNKRFQEWGLENTVIRNLLPDLEGTNTTSPRDLGILLAKVNQGDLLSVRSRDRLLEIMRRTKTQTLLPQGLENNAIIAHKTGDIGTVLGDAGIIDMPTGKRYIGAVLVKRPHNDYSARTLIQEISRTAYQHFKWYLARPPISSNETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P1</accession>
    <name>K9Z2P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YCII-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218571.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0704"/>
    <dbReference type="EnsemblBacteria" id="AFZ52840">
        <property type="protein sequence ID" value="AFZ52840"/>
        <property type="gene ID" value="Cyan10605_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0704"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.737"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_5_1_3"/>
    <dbReference type="OMA" id="NGIWTEY"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="10351" checksum="0EEA5692A82C141C" modified="2013-03-06" version="1">MAKYILFGSYCENALEKRTPYRQAHLEGLAKQKEEGILVTLGPTKDNTKVFGIYEADSQETVENLVKSDPYWQNGIWTEYEVKEWIQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S5</accession>
    <name>K9Z2S5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219183.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1340"/>
    <dbReference type="EnsemblBacteria" id="AFZ53454">
        <property type="protein sequence ID" value="AFZ53454"/>
        <property type="gene ID" value="Cyan10605_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1340"/>
    <dbReference type="eggNOG" id="COG2981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007811_0_0_3"/>
    <dbReference type="OMA" id="PFADDWS"/>
    <dbReference type="OrthoDB" id="1972181at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="30178" checksum="66A7601F2D6213E6" modified="2013-03-06" version="1">MSRSIVTGFGFFSGVFYPFLALKIIWQNKTLWQYLIIPILINILVGIISYILLLNPSLNFYDNFTNNLILRVDQLIDSLPQWLEFLTYIISAIASFLKGIIIIILLILVGFVILQFGGILGSHFYGKLSEKIEILKKGNLDLIEINIVREIFRAILFELKKLLFIIVFSIPLFLLNFIPAFGNLISLIGGLSITITIICLDFFDATLERKRLSFREKLKFVWGGFPLTTGFGLICLALISIPFVNLIAIPICVSAGTLLICDHNTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V6</accession>
    <name>K9Z2V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0782"/>
    <dbReference type="EnsemblBacteria" id="AFZ52915">
        <property type="protein sequence ID" value="AFZ52915"/>
        <property type="gene ID" value="Cyan10605_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0782"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.823"/>
    <dbReference type="HOGENOM" id="CLU_2896544_0_0_3"/>
    <dbReference type="OMA" id="RVIYPDY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="7127" checksum="7DBA4E5975AD9F35" modified="2013-03-06" version="1">MAVRIINPEYVRGFVGYLLMQESSSRWLVKVIIKETHLPKNSEMLVLSLEESDFEILHHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V7</accession>
    <name>K9Z2V7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218793.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0932"/>
    <dbReference type="EnsemblBacteria" id="AFZ53062">
        <property type="protein sequence ID" value="AFZ53062"/>
        <property type="gene ID" value="Cyan10605_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0932"/>
    <dbReference type="eggNOG" id="COG4067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099424_1_1_3"/>
    <dbReference type="OMA" id="MRFRMLL"/>
    <dbReference type="OrthoDB" id="1576021at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008503">
        <property type="entry name" value="Put_Zn_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05618">
        <property type="entry name" value="Zn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_protease" evidence="1">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="18049" checksum="41E2D100943C7668" modified="2013-03-06" version="1">MNDHSHHKNLPLIGWREYLSLPELGVEKIKAKIDTGARTSALHAYHIHPYQERDPEGIGGTGRTLIKFQVHPIQRETHTTVSCIAPLLEYRKVTSSGGHATVRPVIITSVQLGDYNWDIELTLTNRDVMGFRMLLGREAIRKRFLVDAGNSFLNKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z307</accession>
    <name>K9Z307_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218838.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0977"/>
    <dbReference type="EnsemblBacteria" id="AFZ53107">
        <property type="protein sequence ID" value="AFZ53107"/>
        <property type="gene ID" value="Cyan10605_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0977"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1031"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_2_3"/>
    <dbReference type="OMA" id="ITWVFGG"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="40359" checksum="731ACF181CBA43A4" modified="2013-03-06" version="1">MNGNIRVGSLFGIPFYINPSWFLILGLMTLTFGTDLAYQTNLPGLVPFLLGLVASLLLFSSVLAHELGHSFVAISQGIEVKSITLFIFGGLAALEKESKTPEQAFFVAIAGPVVSLILFAIFLIIETNFTLPIALQLIVSLLATINLVLALFNMIPGLPLDGGNVLKAIVWKITGNPQKGVIFAGRFGQFFGWTAITIGAMGTLGIIPFGNFWTVLIGWFLLQNAGTAAQSAQLEDKLNHYYAKDAISPESPVIQGNLTIRQFVNEYVIGKQPWRKFLVTDEDGILTGVLHLDDIRAIATSQWNEVFVHQVMKSKEEVKTVVDTLSLLEVVKLLEQQQDLELTVVKENGFVVGLIEKQGIIKFLQSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z318</accession>
    <name>K9Z318_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218848.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0987"/>
    <dbReference type="EnsemblBacteria" id="AFZ53117">
        <property type="protein sequence ID" value="AFZ53117"/>
        <property type="gene ID" value="Cyan10605_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0987"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1043"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035296_0_0_3"/>
    <dbReference type="OMA" id="PCRTVGR"/>
    <dbReference type="OrthoDB" id="353872at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="422"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="563" mass="64427" checksum="5CCFBC718A1514F5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z366</accession>
    <name>K9Z366_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218893.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1036"/>
    <dbReference type="EnsemblBacteria" id="AFZ53162">
        <property type="protein sequence ID" value="AFZ53162"/>
        <property type="gene ID" value="Cyan10605_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1036"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1098"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013645_1_0_3"/>
    <dbReference type="OMA" id="KHQPLYA"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="67"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="397" mass="45604" checksum="B08944520464B011" modified="2013-03-06" version="1">MSIDDFDFAKLIAPIDLNTFINEYWEKKPLIISRNQKNYYQDLLSVEDLDSILQYSKLKPPEIRVVKNQQDFLPDRYVKADGSLNLNQLYKAYYEDHTLVVNGLQNFWKPLAIYCQKLQNFFNHGVIANLYLSPKDSKGLSPHYDTHDVFVLQVDGSKEWQVHQCFQPVPLLGSFQPVIPENSLPKLLHTVCLQPGDLLYLPRGFVHHAATQESFSLHLTLGIYPTQWLDLMVNALTMLALKNQDLRKALPIGFLDKPEMLGEIKEQFDQLLQTFAEKSSIDEAMELIYDQFIHKITPIPDGHFQQVNLVDAIAPDTLVVKREGMRCRIVKKGFSISIQFPGNSINGGLHYREAMEFVAKQKEPFTAQMLPDSLKEEQKTQLISRLIRGGLLKTLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B6</accession>
    <name>K9Z3B6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218816.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0955"/>
    <dbReference type="EnsemblBacteria" id="AFZ53085">
        <property type="protein sequence ID" value="AFZ53085"/>
        <property type="gene ID" value="Cyan10605_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0955"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1008"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_0_3"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="33083" checksum="89D1EEECB9421EDD" modified="2013-03-06" version="1">MTTKILLFGSNGQVGTELSTHLSKIGDLTLINRSIVDLTSEKDVRNCIRDCKPQFIVNAAAYTAVDKAESEPQLAQQINAIAPQIIAEESNKINAQFIHISTDYVFDGKSNIPYLESDNTNPLGVYGKSKLQGEENIKENSDNYIILRTAWVYGKYGKGNFLKTMLRVGEERDILKVVIDQIGCPTYAEDIAIIIKKIIEQNKGEKYRQDIYHFTNLGVCSWYDFAVNIFRQARKLNYPLKVKEIIPISTTEYPTPAQRPAYSVLSTRKIRNDYNINGDYWLESLERYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D3</accession>
    <name>K9Z3D3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218963.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1110"/>
    <dbReference type="EnsemblBacteria" id="AFZ53232">
        <property type="protein sequence ID" value="AFZ53232"/>
        <property type="gene ID" value="Cyan10605_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1110"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043658_0_0_3"/>
    <dbReference type="OMA" id="WQAAEYL"/>
    <dbReference type="OrthoDB" id="1058535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014951">
        <property type="entry name" value="DUF1822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08852">
        <property type="entry name" value="DUF1822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="459" mass="53561" checksum="F95C3B4F45178633" modified="2013-03-06" version="1">MNIINFISDCYANELKIALDENIKRQTWQEVKNLSTEINRHCGYINLLSRKYFIQWLNLVCNINITDTNNIIDYITIWEFINGNAINVNNNRLVLIPTETQDRVSISIPKEWLKIPEWVGSYYVIVGVNLEENYLDFWGYINYDNLQENGETDNLNHTVNLPYECLETDLNLMALEYEYSWENIPQVSPLKCLSPQIQKNLITELENSFFPRLSLDFSDWLSLVSIADARYKLYSHRQSISLGDLLKNKTENILRKGWQSLQDFIKDNFETDFDLKMSPAFRSISPQEGLNVLVKNDNYGQILEILNTIPNWQIRENLQQEFIRVLVDLINNTNDEEILWSSVFALESLQANHSLCSKGYGKLINFNEENKNYGLLINILPRNFGQISIFVRVSVLSNEDNLPESLSLKILDENEDLFQAIISEKGDNTIQYKFWADEGETFKIQVSCNNNYIEDTFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I6</accession>
    <name>K9Z3I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218674.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52943">
        <property type="protein sequence ID" value="AFZ52943"/>
        <property type="gene ID" value="Cyan10605_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0810"/>
    <dbReference type="eggNOG" id="ENOG5032VUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1814873_0_0_3"/>
    <dbReference type="OMA" id="STALTWG"/>
    <dbReference type="OrthoDB" id="2033321at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16465" checksum="F93CC9707466C7B8" modified="2013-03-06" version="1">MNIILFLITNSLKIFGLFWIAGGLFVCLEVLKSSRMDKYIKAIDFNHKPDYKEYLFSLAIGLLTLLSGVTLIVSQNIAILFLGLLIITQLMFFDFREKKFKASQTDSDKENYSISPQTYNAYLTSIYVTIFALIRYCLNIFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K6</accession>
    <name>K9Z3K6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219431.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1596"/>
    <dbReference type="EnsemblBacteria" id="AFZ53704">
        <property type="protein sequence ID" value="AFZ53704"/>
        <property type="gene ID" value="Cyan10605_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1596"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1695"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240557_0_0_3"/>
    <dbReference type="OMA" id="FIAVIND"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="2">
        <location>
            <begin position="331"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="667"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="785"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="860"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="913"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="750"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1383" mass="158307" checksum="36A6CA400A3AB725" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T2</accession>
    <name>K9Z3T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219588.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1759"/>
    <dbReference type="EnsemblBacteria" id="AFZ53861">
        <property type="protein sequence ID" value="AFZ53861"/>
        <property type="gene ID" value="Cyan10605_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1759"/>
    <dbReference type="eggNOG" id="ENOG5032ZIH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192957_0_0_3"/>
    <dbReference type="OMA" id="MAWEESD"/>
    <dbReference type="OrthoDB" id="2001776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10316" checksum="6706943170CB2E61" modified="2013-03-06" version="1">MEKVLISSGTKQKITVTVDSNLIADIDNFTNNRSAAVEEALFLWRQQQFEAKLREFYLNRSGNALKDDENWSETTQDNAIANWDESTENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V7</accession>
    <name>K9Z3V7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218979.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1128"/>
    <dbReference type="EnsemblBacteria" id="AFZ53250">
        <property type="protein sequence ID" value="AFZ53250"/>
        <property type="gene ID" value="Cyan10605_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1128"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1195"/>
    <dbReference type="eggNOG" id="COG3431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113758_1_0_3"/>
    <dbReference type="OMA" id="LMTVYER"/>
    <dbReference type="OrthoDB" id="1671244at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="153" mass="17549" checksum="A7465F993985F3DE" modified="2013-03-06" version="1">MLNKIISWLNDFFKDRNFMKLIHITENLVSKVLSIALIIVIFVSIFDLILVLSQDLFVQEPVGFFNVTLIEIFGFFLNVLIALELLENITVYIRKHVVQLELVLTTALIAVARKIIIFDTSKYDKVDLIALGFATLCLALSYGIICYIHKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V8</accession>
    <name>K9Z3V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219546.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1716"/>
    <dbReference type="EnsemblBacteria" id="AFZ53819">
        <property type="protein sequence ID" value="AFZ53819"/>
        <property type="gene ID" value="Cyan10605_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1716"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_3_0_3"/>
    <dbReference type="OMA" id="FEYNILK"/>
    <dbReference type="OrthoDB" id="1276248at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939096" evidence="3">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="31549" checksum="F08EA275965B3265" modified="2013-03-06" version="1" precursor="true">MSLIKKSLFVASVIISPLIYSPIQVNAQNSNMSFSQWCEQQSLSAETEKTINAITKALNVKNCAEAAEIAPRVFTLTIANQNISDLRPLKSFINLTDLNLYNNNIVDISPLQSMTNLKKVVLGHNPIQDLTPLKSLNNLEKLYISNINTNNFEAIKYLKKINTLYINQNKISDLKPLENLTNLQELYARENKISDLKPLANLTNLQELSLDNNQISDLTPLAKLSKLEELSLNNNQVTEAGIKPLWDLKNLERVYLHQNPVARQFCPNNRDSLCFIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W9</accession>
    <name>K9Z3W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219623.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53896">
        <property type="protein sequence ID" value="AFZ53896"/>
        <property type="gene ID" value="Cyan10605_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1794"/>
    <dbReference type="eggNOG" id="ENOG502ZJPA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2272711_0_0_3"/>
    <dbReference type="OrthoDB" id="2049956at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11081" checksum="CBA07E8CED6C7D20" modified="2013-03-06" version="1">MVEPSFAQTSSSPIEEDVSITGDSLQGLDSSSLAGNQSNTPKWDVTVEREKKKPSFSTGNEFFDSLLQKQSEPPKTSTEEKINTNKGDVPVNQGGTIPLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z2</accession>
    <name>K9Z3Z2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein</fullName>
            <shortName evidence="12">DPOR subunit L</shortName>
            <shortName evidence="12">LI-POR subunit L</shortName>
            <ecNumber evidence="12">1.3.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">chlL</name>
        <name evidence="14" type="ordered locus">Cyan10605_1752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.</text>
    </comment>
    <comment type="function">
        <text evidence="2">The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:28202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10002"/>
            <dbReference type="Rhea" id="RHEA-COMP:10004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83348"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.3.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Protochlorophyllide reductase is composed of three subunits; ChlL, ChlN and ChlB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 13">Belongs to the NifH/BchL/ChlL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.7" evidence="12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219581.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1752"/>
    <dbReference type="EnsemblBacteria" id="AFZ53854">
        <property type="protein sequence ID" value="AFZ53854"/>
        <property type="gene ID" value="Cyan10605_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1752"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1859"/>
    <dbReference type="eggNOG" id="COG1348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059373_2_0_3"/>
    <dbReference type="OMA" id="YVCDYYL"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016636">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036068">
        <property type="term" value="P:light-independent chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019685">
        <property type="term" value="P:photosynthesis, dark reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00355">
        <property type="entry name" value="ChlL_BchL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030655">
        <property type="entry name" value="NifH/chlL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000392">
        <property type="entry name" value="NifH/frxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005971">
        <property type="entry name" value="Protochlorophyllide_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42864">
        <property type="entry name" value="PTHR42864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00142">
        <property type="entry name" value="Fer4_NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000363">
        <property type="entry name" value="Nitrogenase_iron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01281">
        <property type="entry name" value="DPOR_bchL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00746">
        <property type="entry name" value="NIFH_FRXC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00692">
        <property type="entry name" value="NIFH_FRXC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51026">
        <property type="entry name" value="NIFH_FRXC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 12" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="31646" checksum="C3DE2D414A32E2CB" modified="2013-03-06" version="1">MTLTLAVYGKGGIGKSTTSCNISTALAKRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQEKDFHYEDIWPEDVIYKGYAGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDVILFDVLGDVVCGGFAAPLNYADYCLIVTDNGFDALFAANRIAASVREKARTHPLRLAGLIGNRTSKRDLIDKYVSHVAMPVLEVLPLIEDIRVSRVKGKTLFEMAEKDPTLDYVCDFYLNIADQILALPEGVVPSEAHDRELFGLLSDYYLNPPQAKEEKEDELELMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z8</accession>
    <name>K9Z3Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218834.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0973"/>
    <dbReference type="EnsemblBacteria" id="AFZ53103">
        <property type="protein sequence ID" value="AFZ53103"/>
        <property type="gene ID" value="Cyan10605_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0973"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_3"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="33196" checksum="B4A9100C27731D1E" modified="2013-03-06" version="1" precursor="true">MTSSRWLKILNPYLFLLPALIVLGIIVFFPAIQAFSLSFTRYEYDLTQPPEWIGWENFRQLSEDKVFRQTLINTLIYLLGVVPPLVILSLLLAILVNQKLKAITWFRGAYYTPVVVSMVVAGLAWKALYWSNGLFNQFLRSIGLEDGIPWLTSPNWAIWSLMIVTVWKGLGYYMVIYLAGLQSISPELYEAGAIDGSDGWRKHLDITIPLMSPYIFLVAVISALSATKVFEEVYLLTQGGPRNASKTVVYYLYEKAFKELDISYACTMGLVLFVFILVLSIANLYLSKRVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z405</accession>
    <name>K9Z405_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP fibrillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219596.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1767"/>
    <dbReference type="EnsemblBacteria" id="AFZ53869">
        <property type="protein sequence ID" value="AFZ53869"/>
        <property type="gene ID" value="Cyan10605_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1767"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1875"/>
    <dbReference type="eggNOG" id="ENOG502ZB4T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069245_1_1_3"/>
    <dbReference type="OMA" id="QYSTARE"/>
    <dbReference type="OrthoDB" id="1381917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PTHR31906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAP_fibrillin" evidence="1">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="24232" checksum="704D625BBEE5E3BE" modified="2013-03-06" version="1">MNSRLLLKQELLDSISKVAQTLNINPQYPITDTLISGDDSLKIEKITLNLEALNPFPKPLVYGVNLLDGIWQLNYSTAREIRSLNKLPLGLKLRQVYQIIDTQKTSFFNVAFVEHSSGLVKGYVKVTATFSPQIKDGDLLPQDTINVNFDKRFLAIQKIVNIKTPIFEPVKVFNARNPQGRIPSLKVTYIDESMRIGRGGDGSLFILSKVNKIADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z483</accession>
    <name>K9Z483_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1847"/>
    <dbReference type="EnsemblBacteria" id="AFZ53949">
        <property type="protein sequence ID" value="AFZ53949"/>
        <property type="gene ID" value="Cyan10605_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1847"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_46_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="444"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="591"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="847" mass="97656" checksum="986D072E4F3DD269" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z497</accession>
    <name>K9Z497_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219691.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1863"/>
    <dbReference type="EnsemblBacteria" id="AFZ53964">
        <property type="protein sequence ID" value="AFZ53964"/>
        <property type="gene ID" value="Cyan10605_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1863"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1976"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1861881_0_0_3"/>
    <dbReference type="OMA" id="FQAGPKA"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15239" checksum="0ADD1DD3DB5CD6AD" modified="2013-03-06" version="1">MKRLVLDAGPLIALVSERDNYHSEAKLGFSQISLLFGEVLTPLPILFEVYKFVSRNESPKIAQKLLSVIQKETVIVTISESDFVSISDLVLNFSHWGGTLEDASVIVIAKKYQGKIWTIDYKDLGFFGDIEFWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A4</accession>
    <name>K9Z4A4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219149.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1305"/>
    <dbReference type="EnsemblBacteria" id="AFZ53420">
        <property type="protein sequence ID" value="AFZ53420"/>
        <property type="gene ID" value="Cyan10605_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1305"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1378"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_3"/>
    <dbReference type="OMA" id="IIYGQSE"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="41829" checksum="CA9A30B634C69E8A" modified="2013-03-06" version="1">MQIYLDSCATTAPHPEVVKLVQEIMKDNWGNPSSLHFWGERSAMVLEKARFSVASLLNADSGDNIIFTSGGTEADNLAIFGTVYNYSQPQHIIISSVEHSAIASPVTMLEKQGWQVTRLPVNREGRVNPDDLRKSLRDNTVLVSIIYGQSEVGTIQPITELADITKTHSKALFHTDAVQIMGRYEVDVSALKIDLLSLSGHKFYGMQGAGALYIREGIELQPLIGGGGQELGLRSGTQALCAIAALGLASQLAQKDLESESLRLRELRDYFIDLVEQECPYLQLTGDRYYRLPHHASFIINHPHREITGRKMVRDLNLAGIGISAGSACSSGKSLPSPTLLAMGYSETEALRGIRISCDRTTTKEDLEWVVMVINQLMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D0</accession>
    <name>K9Z4D0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219174.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1330"/>
    <dbReference type="EnsemblBacteria" id="AFZ53445">
        <property type="protein sequence ID" value="AFZ53445"/>
        <property type="gene ID" value="Cyan10605_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1330"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1404"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032479_0_0_3"/>
    <dbReference type="OMA" id="NWRATHI"/>
    <dbReference type="OrthoDB" id="819966at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="303"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="459" mass="52864" checksum="13E81DBF2EFAB7A6" modified="2013-03-06" version="1">MLTVGGTSISLIALLQIVIALILVIIIGKIFKKIFKENILNKLNIDSANRETFANIISYFFGAILFILLLQYFGVNLSTLAVIGGGLGLGIGFGLQDITKNFISGLTLLFERPIKPGDFIEIENIKGYVTEISTRSTVVETQDGSEIFIPNSFFINHRFTNWSYNSFTARIIIPIAVAYQSDLVLVTELLLQSAYQESRVVAHPSPEVLLVGFGDSSLNLELRVWINPIDQEPEIRSNLNFIIEYLFRQYNITIPFPQRDVWLKNYSDVLENKNINISQEKNNQNHHHKSKKSIKDMLWEVDYFQDFNEIEIRKLIESGYRKNLEKEQILFKENEIGDTFYIILSGKVEVFVEKINKHLNYLKAGSFFGELSLMLGMPRTATVKAVEPTILFCINQANFRKLLMKNPELYDLIVNKLSERKNELVERQNELRRMGLIDKEEDDNNPLIWVRNRLKKLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D6</accession>
    <name>K9Z4D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_1955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1955"/>
    <dbReference type="EnsemblBacteria" id="AFZ54051">
        <property type="protein sequence ID" value="AFZ54051"/>
        <property type="gene ID" value="Cyan10605_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1955"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2077"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_3"/>
    <dbReference type="OMA" id="VFWLFKL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="105"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="29482" checksum="4C7B0D0AD67D7CBA" modified="2013-03-06" version="1">MANFLTLLIIFSFGASIGSFLNVVIYRIPEKISLVYPPSRCPKCKHPLGKTENIPVVGWLWLKGKCRWCHTPISPRYPLIEAMTGFFFVLIFQHFGFSWLTLGYMAFISWLIALALIDFDTMTLPNSLTQSGLVLGLFWQGWFGFNLSDGNVKGLVLSLFSAIVGGVVGIWLFDTILIVGSIVFGKAAMGGGDPKLASMIGVWLGWQGVLITGFLACAVGTIVGIGAIAFRLMKKGQPMPFGPYLVIGAIITMFWGDYLISSYLELVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J6</accession>
    <name>K9Z4J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219384.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53657">
        <property type="protein sequence ID" value="AFZ53657"/>
        <property type="gene ID" value="Cyan10605_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1548"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1643"/>
    <dbReference type="eggNOG" id="COG4445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056571_1_0_3"/>
    <dbReference type="OMA" id="CEFKAAS"/>
    <dbReference type="OrthoDB" id="1900811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07910">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="197" mass="22678" checksum="F12D07938F8F09C4" modified="2013-03-06" version="1">MFSFTKINLLCQPTQSAWLEQALDNLDLILLDHSHCERKAAGVAVNFLFRYPAHEDLVYQLTAIAQEELEHFEQVNQWLKRKNIPLAPLKPSPYGATLKQAIKKQEPHRLLDSLLVSALIEARSHERLGLLAQHCPDLELAKFYRGLMASEARHYGIYWVLATQYFDRTIVDLRLSELAQLESDTLSNLHPEPRIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M5</accession>
    <name>K9Z4M5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit may be involved in monitoring complementarity of crRNA and target RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1229"/>
    <dbReference type="EnsemblBacteria" id="AFZ53348">
        <property type="protein sequence ID" value="AFZ53348"/>
        <property type="gene ID" value="Cyan10605_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1229"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1297"/>
    <dbReference type="eggNOG" id="COG1421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131491_2_2_3"/>
    <dbReference type="OMA" id="KEYPIRD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010149">
        <property type="entry name" value="CRISPR-assoc_prot_Csm2_III-A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03750">
        <property type="entry name" value="Csm2_III-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01870">
        <property type="entry name" value="cas_TM1810_Csm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="176" mass="20126" checksum="A8C5186E0D078562" modified="2013-03-06" version="1">MDKPRLNQPPNRGNITQKTQNSNKNNNSQNKSEGQKQTNMTSTQTILNSLKNTETFKEYPIRDLVKHSEEFGRYLKNQRLETNQIRKFLDAINRLKVKLTQAGENEDKAQLFRLVEPEIVLLKPKLAYAAARVDAAKPLSEVMAQVIDKVQSLDDFERLVQFIESIIAYHKAAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N0</accession>
    <name>K9Z4N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219824.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2005"/>
    <dbReference type="EnsemblBacteria" id="AFZ54099">
        <property type="protein sequence ID" value="AFZ54099"/>
        <property type="gene ID" value="Cyan10605_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2005"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2129"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_3"/>
    <dbReference type="OMA" id="VYYKPKY"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50331"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="366" mass="41186" checksum="689FF8636508EC41" modified="2013-03-06" version="1">MATVTLQNIARSYNQVKVISNITFEVPDGEFWVLVGPSGCGKSTILRSIAGLESISEGNLYFDGVLMNEIPARERDVAMVFQNYALYPHLTVADNLGFGLRMRGEKKSLIDNKIKQVAEILDIGHLLMRKPKQLSGGQQQRVALGRAIIRQPKVFLLDEPLSNLDAKLRDQTRTELKKLHSQVGITTVYVTHDQVEAMTLGDRIVVLNQGRIQQIGTPAEIYQNPVNRMVATFLGTPSMNIIPVTYHDGAFWINEQQSLRLPPPFLKQYNFHNGQGWDLGIRPEYITLVKDQENALDNFLVTTVEVIEPLGKEVLVNAKIVDSEININLQLPIQWQGKMGDELKLQLDLEQIYLFEPTTGEIIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U4</accession>
    <name>K9Z4U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type uncharacterized transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2092"/>
    <dbReference type="EnsemblBacteria" id="AFZ54181">
        <property type="protein sequence ID" value="AFZ54181"/>
        <property type="gene ID" value="Cyan10605_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2092"/>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018716_0_0_3"/>
    <dbReference type="OMA" id="YGQHPIT"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="3">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="518" mass="58340" checksum="630529828AD1B7A1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X9</accession>
    <name>K9Z4X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1689"/>
    <dbReference type="EnsemblBacteria" id="AFZ53792">
        <property type="protein sequence ID" value="AFZ53792"/>
        <property type="gene ID" value="Cyan10605_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1689"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1792"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_3"/>
    <dbReference type="OMA" id="IVIWRQG"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="161"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="522" mass="60669" checksum="4116E20C4A84A6BF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z501</accession>
    <name>K9Z501_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219382.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1546"/>
    <dbReference type="EnsemblBacteria" id="AFZ53655">
        <property type="protein sequence ID" value="AFZ53655"/>
        <property type="gene ID" value="Cyan10605_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1546"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1641"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_3"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="290"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="606" mass="66369" checksum="ACA35DA0E7743AA2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z546</accession>
    <name>K9Z546_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219984.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2173"/>
    <dbReference type="EnsemblBacteria" id="AFZ54259">
        <property type="protein sequence ID" value="AFZ54259"/>
        <property type="gene ID" value="Cyan10605_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2173"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2309"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_3"/>
    <dbReference type="OMA" id="NRDHGAI"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="321" mass="35532" checksum="8EC73C9DA2E9782B" modified="2013-03-06" version="1">MIKVGLVGTGYAAQRRAEAFQANPLTELVAVVGNSVETTASFCETYGIPSVSGWQQLVNDSSLDLICISNINRDHGMIVRGALLADKHVIVEFPLTINPDEAEELLSLAQEKNKLLHVEHIEILGGVHQAIRANLSAIGDPFLARYTTILPKSSLMNKWTFNYEYYGFPFIAALSRINRFTDLFGEVDSVSCYGRFWDAEKVGYFSACYTQAQLSFKNGLLACLTYGKGEQFKSSDRTLEIYGTQGTLRFEGETGKIIRDGEENAIEVGTRRGLFVKDTEAVIDYLTTGKPLYIENKASVYALRVANATLKAYQSQSICKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z550</accession>
    <name>K9Z550_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220031.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2220"/>
    <dbReference type="EnsemblBacteria" id="AFZ54306">
        <property type="protein sequence ID" value="AFZ54306"/>
        <property type="gene ID" value="Cyan10605_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2220"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2359"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223906_0_0_3"/>
    <dbReference type="OMA" id="TEAFKWF"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="26392" checksum="0A053C1A0EB66C93" modified="2013-03-06" version="1">MQPIENLIDQIQKEAQREEFPIDIPVYKNCEKDPTKPILYYGNLKSNICFFGRDLGRDEVKAGQPLIGAAGQLVRQGFYKAIYQEELINEEKLASIKERLILTNTVPYKPPENKAYAMKVKKRFRPFIEQLLVIYWQGTQIITLGTEAFKWFEYYSNKDKFNAFWSKGDSRYESSLNVTISTMGDKGKTYQKNVTIYPLPHPSPLNQKYYNRFPSMLENTLSRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B8</accession>
    <name>K9Z5B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase subunit MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1835"/>
    <dbReference type="EnsemblBacteria" id="AFZ53937">
        <property type="protein sequence ID" value="AFZ53937"/>
        <property type="gene ID" value="Cyan10605_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1835"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1948"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_2_3"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="17898" checksum="B028F8E672EF0A94" modified="2013-03-06" version="1">MVCGALGKKIDITIMSYFTDFKITFAPLCLTEVYQLADNPANGAIALMSGTVRCQTEGKKVEYLEYQAYEPMAVTIFKQIGANLVNQYPDINSIIIHHRVGKLVIGDISVLVAVGCPHRREAFKACQYAIDTLKHNAPIWKKEHFADGASSWVSIGMCEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H0</accession>
    <name>K9Z5H0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ordered locus">Cyan10605_2305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220113.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2305"/>
    <dbReference type="EnsemblBacteria" id="AFZ54389">
        <property type="protein sequence ID" value="AFZ54389"/>
        <property type="gene ID" value="Cyan10605_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2305"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2449"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_3"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111451" checksum="904E4B1B84461A30" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L6</accession>
    <name>K9Z5L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220163.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2355"/>
    <dbReference type="EnsemblBacteria" id="AFZ54439">
        <property type="protein sequence ID" value="AFZ54439"/>
        <property type="gene ID" value="Cyan10605_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2355"/>
    <dbReference type="eggNOG" id="ENOG5031IQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054211_0_0_3"/>
    <dbReference type="OrthoDB" id="1879942at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="28140" checksum="ACB1FA24C4E58232" modified="2013-03-06" version="1">MANYPFILTSELVNIKHGKYIVKVCVHQNQQIISTAHSEGYTVEEAEDNARKRAILFANESVNVHNVQNIPVSTTNKVTSPPPVEQKSKPPTNSPSTKTNLSENITHPPAPPQKPPIKPPMSPQKETKPSEITPPPLQNESSPEEITPPPINHRDESLPLEIPENHNGKEEILSAPTNDIEESPTLPLSLETNETMDFSQIIDQTTFEMKRLGWTQDQGKKYLLETYGKKSRHLLSDQELIEFLQYLQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P6</accession>
    <name>K9Z5P6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220239.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2435"/>
    <dbReference type="EnsemblBacteria" id="AFZ54516">
        <property type="protein sequence ID" value="AFZ54516"/>
        <property type="gene ID" value="Cyan10605_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2435"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2579"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_3"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939119" description="Phosphate-binding protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="57"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="380" mass="40141" checksum="23D3B554C2ED8B5E" modified="2013-03-06" version="1" precursor="true">MKTKQLFRSVSALFVALSLTACGGGGQPTENTTGGGETTGGGETASSTTIEVPFEGTVSLNGAGASFPAPLYQNWFVSLAQVQPKLQVNYQSVGSGAGVEQFTQQTVDFGASDVAMKDEEIDAIDRGVLLLPMTAGSIVYAYNLPGVEGLKLSRETYVGIALGKITNWNDPKIAADNPDLTLPDLPITFVHRSDGSGTTGVFTMHLSAISPEWKDTIGEGKTVQWPSTGNFIGGKGNEGVTAAISQTEGAIGYVEYGYAKNNGLTMASLQNQAGNFIVPSDESASKTLANVELPENLRAFITDPEGDESYPIVTYTWMMAYKTYDDPNKAIAMEAMIQYGLTEGQKAAPELGYIPLPANVVEKVAAAADQITPDYTITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S6</accession>
    <name>K9Z5S6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ordered locus">Cyan10605_1823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1823"/>
    <dbReference type="EnsemblBacteria" id="AFZ53925">
        <property type="protein sequence ID" value="AFZ53925"/>
        <property type="gene ID" value="Cyan10605_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1823"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1934"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_7_1_3"/>
    <dbReference type="OMA" id="TGRGVQM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="393"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="562" mass="62515" checksum="88DAB21F55BA2D74" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T2</accession>
    <name>K9Z5T2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ferrochelatase</fullName>
            <ecNumber evidence="7 8">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemH</name>
        <name evidence="9" type="ordered locus">Cyan10605_1626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="7 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219460.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1626"/>
    <dbReference type="EnsemblBacteria" id="AFZ53733">
        <property type="protein sequence ID" value="AFZ53733"/>
        <property type="gene ID" value="Cyan10605_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1626"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1726"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_4_1_3"/>
    <dbReference type="OMA" id="LGDPYHC"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="387" mass="44068" checksum="14A77661E2188094" modified="2013-03-06" version="1">MGRTGVLLLNLGGPEKLEDVRPFLYNLFSDPEIIRLPFPWLQKPLAWLISTLRSKKSEENYLEIGGGSPLLQITEAQAQALQSKLSGQGSDIQVYVGMRYWHPFTEEAIARIKEDGIEKLVILPLYPQFSISTSGSSFRVLEEMWKTDPQLQKIEYTLIPSWYNHPDYLSAMADLIKQELQQFEQPEKVYIFFSAHGVPKTYVTEAGDPYQVEIEECTQLIMKTLNTGNPYILAYQSKVGPVEWLKPYTEDALEELGAKNIKDLLVVPISFVSEHIETLQEIDLEYREVAEEVGISNFKRVPALNTHPMFIDALTNLTTSALEETPLRFDQVTHPKKNMKMYPQEKWEWGLTTVAEVWNGRLAMVGFLALLIELISGHGPLHLVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U1</accession>
    <name>K9Z5U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220279.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2475"/>
    <dbReference type="EnsemblBacteria" id="AFZ54556">
        <property type="protein sequence ID" value="AFZ54556"/>
        <property type="gene ID" value="Cyan10605_2475"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2475"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2624"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054109_0_0_3"/>
    <dbReference type="OMA" id="CVRMYTH"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
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    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="32656" checksum="2F4AF96EE137193E" modified="2013-03-06" version="1">MDENYWIRKLTYEEINFPIEWAKQEGWNPGLYDKDCFYQADSGGFLGGFINNQLIATISAVKYGEKFGFIGFYIVKPDYRKQGYGLKIWQEAIKSLSDRNIGLDGVVSQQDNYRKSGFKLAYRNIRYQGISNHNIEINKTVIDLSSISFEIINNYDKQFFPDDRTNFLKQWIRQPESKVLGIIECDKLRGYGMVKVCDFGYKIAPLFAENFSFAESIFVALQSNIPEGKTFYLDIPEVNHQANILVDKYNLNLVFETARMYNREIPSLPVDKIFGVTSFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W1</accession>
    <name>K9Z5W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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        <property type="entry name" value="Cap10605McrB2P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54576">
        <property type="protein sequence ID" value="AFZ54576"/>
        <property type="gene ID" value="Cyan10605_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2495"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2644"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IRCREGI"/>
    <dbReference type="OrthoDB" id="1172273at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="902" mass="107963" checksum="88E04E66BE9D7337" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y6</accession>
    <name>K9Z5Y6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2520"/>
    <dbReference type="EnsemblBacteria" id="AFZ54601">
        <property type="protein sequence ID" value="AFZ54601"/>
        <property type="gene ID" value="Cyan10605_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2520"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2672"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841166_0_0_3"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="322" mass="37807" checksum="737EE34B14FC9DB1" modified="2013-03-06" version="1">MNLYFLFPQMHINSGGHIAQMKFMAIAQSLTNAYPVTYERKEKDVLYLEDIIRQTPTANSDIYVIHWGPHINKLLTKLKHRNVVYIAHSTGYKFKIPPQVPIIAVSKHSQAYWGRYAPNSLIFHLPNEISPQYQNWHQERPIDVLVQKRKSSQYLLKQLIPALKPHCNLFVIDSWVEDLATLFNQSKVYLYDSSEYWIQAGATEGFGLPPLEAMACGCTVFSSINDALSDYLDPSFNSYKLRVYSQEYDVQRILKVVNNWQDNDHEQLLKPYRIESIEVRFKNILSEINEFFLHQQSYQQNIPLIKKNKWQIIKKIINKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z657</accession>
    <name>K9Z657_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219785.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1965"/>
    <dbReference type="EnsemblBacteria" id="AFZ54060">
        <property type="protein sequence ID" value="AFZ54060"/>
        <property type="gene ID" value="Cyan10605_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1965"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2086"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_2_3"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="86"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="279"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="603" mass="66451" checksum="161CED7BE51B3440" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z668</accession>
    <name>K9Z668_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54639">
        <property type="protein sequence ID" value="AFZ54639"/>
        <property type="gene ID" value="Cyan10605_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2559"/>
    <dbReference type="eggNOG" id="ENOG50335QQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138498_1_0_3"/>
    <dbReference type="OMA" id="KINDDSY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939126" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="114" mass="12683" checksum="37E5D5BD73815D26" modified="2013-03-06" version="1" precursor="true">MKNLISSVIYTSMLILMVNPSYANDLAMKSQNSRFIGYETNPHNLVDLGYQGYFKDSGIPSAGLFLHQVNTGKITAQKLVQIGIDNGRLSADKINDDSYINSVASYLRQLNQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z684</accession>
    <name>K9Z684_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ordered locus">Cyan10605_1816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219645.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z684"/>
    <dbReference type="STRING" id="755178.Cyan10605_1816"/>
    <dbReference type="EnsemblBacteria" id="AFZ53918">
        <property type="protein sequence ID" value="AFZ53918"/>
        <property type="gene ID" value="Cyan10605_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1816"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1926"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_3"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="163"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="36171" checksum="05FBC2F2B015F2F0" modified="2013-03-06" version="1">MFEKILLSNPSAENPSSLRPRKGIIIGLGQVGLACAYSMLIQDCFDELVLQDIASDKLEGEVMDFSHGMPFIPPTDIKAGTIANEGRNADIVIITAGVAQKEGESRLSLLERNIAIYKKILADVVKYCPEAIILVVTNPVDIMTYATLKITGFPSSRIIGSGTVLDTARFRTLLAKEMDIDPRSVHAYIIGEHGDSEVPVWSTANVGGMKLVPNTWADLPEDEKATLSGIFQKVQNAAYDIIKLKGYTSYAIGLATTDIVKAILNSQERILTVSGLMTGMYGIEDVCLSIPRVVSERGIIKTVNLTLSEDEEKLLQQSAKMLKEVFDKINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z690</accession>
    <name>K9Z690_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rodA</name>
        <name evidence="7" type="ordered locus">Cyan10605_2611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220409.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2611"/>
    <dbReference type="EnsemblBacteria" id="AFZ54686">
        <property type="protein sequence ID" value="AFZ54686"/>
        <property type="gene ID" value="Cyan10605_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2611"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2774"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_3"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="407" mass="45151" checksum="B56DF0EAFB5884B3" modified="2013-03-06" version="1">MNHTNRSLDWFLITLVVGISGFGSLIIYTTQLYKQGSDWQQQLIMVVIGSAILLGLSYFPYELLLKFHWFTYGFTNLLLVAVIFFGTTINGAQSWIYIGSFNFQPSEFAKIGLIITLAALLHFRDASRVSRLFPIASTVALPWLLIMAQPDLGTGLVFGAITFTMLYWANANLGWILLILSPLVSAFLFNLFLPAWLIFTVVMIIIAWFTLPRGAIWALITLTVNYMAGILGHILWDLLKPYQKDRLTLFLDPEKDPLGGGYHLIQSRIAIGSGELWGNGLFEGTQTHLNFVPEQHTDFIFSAIGDQLGFVGAIATLIVYWFICLRLVIIANRARDDFGSLIAIGVLGMIAFQTIINIGMTIGLAPITGIPLPLLSYGRSSLLSNFIAFGIVEAIAANIPKKNTSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E3</accession>
    <name>K9Z6E3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta prime subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220474.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2677"/>
    <dbReference type="EnsemblBacteria" id="AFZ54751">
        <property type="protein sequence ID" value="AFZ54751"/>
        <property type="gene ID" value="Cyan10605_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2677"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2842"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_4_3"/>
    <dbReference type="OMA" id="PRLVWEC"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="315" mass="35591" checksum="E674F0D2C66180CF" modified="2013-03-06" version="1">MKPLAKLIGQPLAIELLESAIAINRIAPAYLFIGAEGIGKALAAKCFTEMLLISPDEDYASACQKLYAGNHPDFLWVEPTYNDKGQLLTAKEAEEKGLKRKTAPQIRIEQVREISQFLSRPPLKGDRSVVVIEGAELMAESAGNALLKTLEDPGKATIILIAKSTDSILSTLVSRCQIIPFFRLSEEHLKLVLYRANKAEVLDYPQLVNLSQGCPGKAIADWQKLTDIPSDLINKLTKFPKNIIEGLVLAKEITKNLELDTQLWLADYLQYFYWEKERKSELIISLEKVKKLLFRYVQPRLVWDCFFLENILENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R8</accession>
    <name>K9Z6R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219818.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1999"/>
    <dbReference type="EnsemblBacteria" id="AFZ54093">
        <property type="protein sequence ID" value="AFZ54093"/>
        <property type="gene ID" value="Cyan10605_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1999"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075506_0_0_3"/>
    <dbReference type="OMA" id="NPLENGM"/>
    <dbReference type="OrthoDB" id="1468268at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="30777" checksum="8857B663D19A717B" modified="2013-03-06" version="1">MLANTAVIDIQAQYNSGERNFPKLQLRRIDLRNAQLKGVNLGGCDLSYADLRDADLSGADLSKCYLNEANLSGANLTGANLTGAYLIKAYLTKVNFQKAIVKEAYFTGSFLTRANFYKADLSGAFLNGAHLNGGIFKDASYDNTTRFDKGFNPESLGMQKVSSFNLATSKKVTIGEIITNFETIASITSKYLGGTITGKNFEDSRPDVEWLREFSMDKNGKVNFNGSLSHQATTIQLKWFEKWTNAFVKKSSMIIQDLPNIIEEKHLTVDYLIKKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U6</accession>
    <name>K9Z6U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219843.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2024"/>
    <dbReference type="EnsemblBacteria" id="AFZ54118">
        <property type="protein sequence ID" value="AFZ54118"/>
        <property type="gene ID" value="Cyan10605_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2024"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2151"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="FENEEEC"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="38949" checksum="F60225EB1A53DB9E" modified="2013-03-06" version="1">MTISISTEEFKAIWQESIEKGEIKEYRSKTETITPFPPYLGTGFWREIELRNGLTVLIQDYCYHQKIIEIDKVESSSQLVSSFYLKGGYTSTVDNLFLSREVTPKNNQLFLIKDTIEKDEIPANKPILAIKLIIDKEFLNHLCFESNHPLFQHLERWRKDQEIEPFLYNCQTSAHLETLLKQIIDCPYQGCLAQMYLESKIMDLLRLQFEQILTLEIEQKLSFNRDDIERIYQAKNILINNYKDPPSLINLARQVGLNDYKLKKGFLHCFQMTVFGYLRHYRLLEAQRLIKDYNYNIAGVASQVGYKSLGSFSSAFKAEFGVSPKQYQKQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X8</accession>
    <name>K9Z6X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GSH synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <shortName evidence="10">GSHase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gshB</name>
        <name evidence="13" type="ordered locus">Cyan10605_2054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219868.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2054"/>
    <dbReference type="EnsemblBacteria" id="AFZ54143">
        <property type="protein sequence ID" value="AFZ54143"/>
        <property type="gene ID" value="Cyan10605_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2054"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2183"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068239_0_0_3"/>
    <dbReference type="OMA" id="WMRKDPP"/>
    <dbReference type="OrthoDB" id="878336at2"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00162">
        <property type="entry name" value="GSH_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006284">
        <property type="entry name" value="Glut_synth_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004215">
        <property type="entry name" value="GSHS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF4">
        <property type="entry name" value="PTHR21621:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02951">
        <property type="entry name" value="GSH-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01380">
        <property type="entry name" value="glut_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="134"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="321" mass="35406" checksum="DDA12B8CA450BEC7" modified="2013-03-06" version="1">MKKFLFIIDPIAQLDPTHDSSVAMMESAQVLGHEVYITTIDKLSVVGGKAYGHISPVTLKPVQLIEGKWIAEKEWYQVGDAFFSPLEFCDVVLMRKDPPVTTAYLYATYILDLVDSQKTKVVNSPQGIRGANEKMYALQFTDVIPETIVTQSKKVIADFLQEKQALILKPLGGKAGEGILFMQEGDRNFNSLIEISTKQGQEPIMVQEYLPSAKEGDKRIILLGGKPIGAVNRIPTGKEFRGNMAVGGRVAQTEITPRELEICDAIAPTLLDDGLIFVGIDVIGGYLTEINVTSPTGIREIDRLDHVNLGQETIKFLLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y7</accession>
    <name>K9Z6Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220626.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2837"/>
    <dbReference type="EnsemblBacteria" id="AFZ54904">
        <property type="protein sequence ID" value="AFZ54904"/>
        <property type="gene ID" value="Cyan10605_2837"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2837"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="463"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="599" mass="70076" checksum="0E12A762F5AE43D2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z716</accession>
    <name>K9Z716_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220084.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2275"/>
    <dbReference type="EnsemblBacteria" id="AFZ54360">
        <property type="protein sequence ID" value="AFZ54360"/>
        <property type="gene ID" value="Cyan10605_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2275"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2417"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012550_2_0_3"/>
    <dbReference type="OMA" id="TFGFAMK"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01569">
        <property type="entry name" value="PBEF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="PTHR43816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005943">
        <property type="entry name" value="NMPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAMPT_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="501" mass="56528" checksum="17B2774C0C7FCA48" modified="2013-03-06" version="1">MNINPLHAIDFYKTDHRRQYPQGTTEVYANFTPRSGRLAKVLDSDDVSVIFFGLQYFIQDYLIDCWNENFFKQDKQKVISAYKRRMDNSLGVGAIPTNHIEALHDLGYLPLRIKALPEGSKVDIGIPLLTVVNTHPDFFWLTNYIESVMSTYLWKPITSATTAFQYKKLLTRYALKTGTSLDFVPLQCHDFSFRGLSGIQDGIISGSAHLTSFYGTDTVLAIDLLENYYHADVTKEIVGVSVPATEHSVMAMGLQDGELETFRRLIEDLYPSGIISIVSDTWDFWKVVTEYTAILKEKILNRDGKVVLRPDSGDPVKIICGDEKALPYTPENKGAIQCLWEIFGGTMTPQGYKMLDSHIGLIYGDSITLDRASQILSKLEEKGFASGNVVFGIGSYTYQYVTRDNFGFAVKATSGVVNHQRRNIFKNPKTDNGVKKSAKGLLRVEQEGDRFVLYEEQTEAQEKQGVLDTVFLNGKLIKSHSLAEIRQRICELSFCPTENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z757</accession>
    <name>K9Z757_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220698.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2917"/>
    <dbReference type="EnsemblBacteria" id="AFZ54979">
        <property type="protein sequence ID" value="AFZ54979"/>
        <property type="gene ID" value="Cyan10605_2917"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2917"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3104"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058393_1_0_3"/>
    <dbReference type="OMA" id="KAWWHME"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="41"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="34623" checksum="024C15877A75B8CE" modified="2013-03-06" version="1">MTQVSLLKAQSYELQELRNSLASLLAPFGGMSAFVKKGDRVLLKPNLLTASRPTKECTTRKEIVYCVAQMVMEAGGKPFLGDSPAFGSAEGVAKANGYLDLCQELNLPIIEFNSHKYPVENENFHHLRLSKEAMEADVVINLPKIKSHMQLTMTMGVKNLFGCVPGKMKAWWHMEAGKDVNRFGEMLVETAKAIQPNLTIIDGISAHEGNGPSAGEPRELGVLGASDDVFALDVAIASLLNVEPELVPTLNAQKRLGLCSELENIEFPLLKPQELAINDWKLPSALMPIDFGLPRVLRSTFKHLYIRFVKEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z764</accession>
    <name>K9Z764_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D27-like_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220760.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2981"/>
    <dbReference type="EnsemblBacteria" id="AFZ55041">
        <property type="protein sequence ID" value="AFZ55041"/>
        <property type="gene ID" value="Cyan10605_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2981"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3175"/>
    <dbReference type="eggNOG" id="ENOG502ZAR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076741_1_1_3"/>
    <dbReference type="OMA" id="MSCEMVF"/>
    <dbReference type="OrthoDB" id="1397065at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038938">
        <property type="entry name" value="D27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025114">
        <property type="entry name" value="D27-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33591">
        <property type="entry name" value="PTHR33591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13225">
        <property type="entry name" value="D27-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D27-like_C" evidence="1">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="24562" checksum="6A77F4892AEED975" modified="2013-03-06" version="1">MNVTDKTEYKDNWFDRLFIALFSRKMAKAVGKKSQKKGYEGFVDLSMQIMEGRNSQQQQELVAIVLQSLVPSPVLFLIRNLFSPTKWVCESNAWFATVLFEWLVGESEIREAEIVTEDNQVTILKSGVYIKKCRYLEASGCVGMCVNMCKLPTQEFFTKSFGIPLTMTPNFDDFSCEMVFGQVPPAFEDEEASRQSCLKHICPTASVTSQPCRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H1</accession>
    <name>K9Z7H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220860.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55141">
        <property type="protein sequence ID" value="AFZ55141"/>
        <property type="gene ID" value="Cyan10605_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3084"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3286"/>
    <dbReference type="eggNOG" id="ENOG5033NSH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965475_0_0_3"/>
    <dbReference type="OMA" id="YDAPYRV"/>
    <dbReference type="OrthoDB" id="2089263at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="32833" checksum="B7DF87DF399F74A7" modified="2013-03-06" version="1">MGFKSFVLIGSIAFCIIFGLQNRGVIVLTFFGFNSPALPLFVWILMALFTGIISSLMINLLSNNPIPKNKKNQSFNPPYSPAPQPSPQPIKAKPNISLNQNPPIEKEKPQYQWEEDDVFEDLPDTPIINTPLPINKLPENEVAYPKTKIESESKTQEHIKETTNKIEEEEKIKIEEPKPIDSPSTEIETENKTSMSEISKLSEEDYPPENLLKPRQASPYSYQSREKTEINPKKTKKNPSQAKESPPQPKRTYKGVYDAPYRVIAPAQTNNTAENYDNFDDEDDDWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X9</accession>
    <name>K9Z7X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GUN4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2774"/>
    <dbReference type="EnsemblBacteria" id="AFZ54842">
        <property type="protein sequence ID" value="AFZ54842"/>
        <property type="gene ID" value="Cyan10605_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2774"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067449_2_0_3"/>
    <dbReference type="OMA" id="ERMVQCN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16383">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008629">
        <property type="entry name" value="GUN4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037215">
        <property type="entry name" value="GUN4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34800">
        <property type="entry name" value="PTHR34800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05419">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140869">
        <property type="entry name" value="SSF140869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GUN4" evidence="1">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="22490" checksum="9BB729CFB710CBB4" modified="2013-03-06" version="1" precursor="true">MNIKALIFSAIISFSFVSLPHQNSFAQSDLSESSSNLVSPETKIDYSNLENYLKNKEWREANNETRNIILSATGRMDIGWVRENDLKKISCEDLKKIDDLWYTNSNGRFGFRVQLPIYIETGNRPGKLIADDAYNRFGDRVGWRKDNDWIIFIENLNFTDNAPIGHLPNPRSEYSVTGGRLAYSVLAERMVQCNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z1</accession>
    <name>K9Z7Z1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2600"/>
    <dbReference type="EnsemblBacteria" id="AFZ54675">
        <property type="protein sequence ID" value="AFZ54675"/>
        <property type="gene ID" value="Cyan10605_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2600"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2761"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="25297" checksum="5661A9721A650050" modified="2013-03-06" version="1">MNSSISTPQPLIKLDNIYKIYGSGDIQVNALSAINLKIESGEYCAIMGSSGSGKSTMMNILGCLDRPTAGNYYLNGKNVADLSRKELAHIRNEQIGFVFQQFHLLPQLSALENVMLPMIYAGISESERKKKATEALIKVGLEARINNKPNQLSGGQQQRVAIARAIVNNPLILLADEPTGALDSETTKEVMSIFRQLNEEKITIILVTHEKDVAEETKRIIHFADGKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z830</accession>
    <name>K9Z830_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220614.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2825"/>
    <dbReference type="EnsemblBacteria" id="AFZ54892">
        <property type="protein sequence ID" value="AFZ54892"/>
        <property type="gene ID" value="Cyan10605_2825"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2825"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071789_0_0_3"/>
    <dbReference type="OMA" id="IRPWSAM"/>
    <dbReference type="OrthoDB" id="1300594at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="31070" checksum="FE3134FDDB0A067E" modified="2013-03-06" version="1">MYNIDINFLKDRKLDSTGGTTAFQKKPTTPLSERVPIFIGTGVGVAFIAAVGGALVLLNGQKSSTNKTIAELDAEIQRLQGQNQQVQQIQTEIDNVNRETGILASVFNNIKPWSAMLAEIAYVTPPSVQINSITQNDTKTLTINGYAQSYDDVNDFLLTLKNSPFLNGENTRLTTSSLTDNPSTVIFDRAQLNSQTQGENGGAGTTPTPGGANTGIQLELPQVILYTITSEISDLSSEQLLNLLNRRGAIGLVSRLSNLQRKGVLQLEAIAEETQEQSEEQEGEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C8</accession>
    <name>K9Z8C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220351.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2548"/>
    <dbReference type="EnsemblBacteria" id="AFZ54628">
        <property type="protein sequence ID" value="AFZ54628"/>
        <property type="gene ID" value="Cyan10605_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2548"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2703"/>
    <dbReference type="eggNOG" id="ENOG502Z7M6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103369_0_0_3"/>
    <dbReference type="OrthoDB" id="1592336at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="25508" checksum="23880020E781BDF7" modified="2013-03-06" version="1">MTLEQFSLLIHPFFVIVTVFPLLGIVFYFAWETFQRHLQIKRGEKSKIPPSVGLNHVTIGKILSSTVFFVTLIGLAQPLITKNILKNELWATDFFLFIFIILIFLFSIVSFIFLYHARVKLWRGIFATLSGMGIVILGSQEGIFRRSNEWYWSHYYYGITICLLMIFSVAIINNIYRDKSQKWRNIHIILNCLALLLFIGQGFTGSRDLFEIGLWTSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I7</accession>
    <name>K9Z8I7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-dependent nickel-iron dehydrogenase catalytic subunit</fullName>
            <ecNumber evidence="4">1.12.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221229.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3475"/>
    <dbReference type="EnsemblBacteria" id="AFZ55511">
        <property type="protein sequence ID" value="AFZ55511"/>
        <property type="gene ID" value="Cyan10605_3475"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3475"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3700"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_3"/>
    <dbReference type="OMA" id="QNNLAMN"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047985">
        <property type="term" value="F:hydrogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="53108" checksum="E281A44DF623275D" modified="2013-03-06" version="1">MGKTVVIDPVTRIEGHAKISIYLDDQGEVNNARFHVVEFRGFEKFCEGRPMFEMAGITARICGICPVSHLLASAKTGDKILGVKILPSAEKLRRLMNLAQITQSHALSFFHLSSPDFLLGWDSNPSTRNVFGLMAADPDLARAGIRLRSFGQNIIELLGARKIHAAWAVPGGVRSPLSESGRQWIMENLPEAKQTTELALSLLKKLLDSQLITEIDTFGKFDSLFMSLVADNGNWEHYGGHIRFVDSQGNIVADKLSEDNYQDYLGEAVESWSYLKFPYYKPLGYPDGIYRVGPLARLNVCDRIGTPQADQELREFRHRAGGRIATSSFFYHYARLLEIVVCLEHIEILMNDPDLLSPKVRSQAGINFLEGIGVSEAPRGTLFHHYQVDENGLIKKVNLIIATGQNNLVMNKTVTQIAKHYIHGLDIPEEMLNRVEAGIRCFDPCLSCSTHAIGQMPLQIELVSSKGEVINTCQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L5</accession>
    <name>K9Z8L5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220657.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2869"/>
    <dbReference type="EnsemblBacteria" id="AFZ54935">
        <property type="protein sequence ID" value="AFZ54935"/>
        <property type="gene ID" value="Cyan10605_2869"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2869"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3049"/>
    <dbReference type="eggNOG" id="COG3040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484726_0_0_3"/>
    <dbReference type="OMA" id="RFWQTRS"/>
    <dbReference type="OrthoDB" id="895767at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021787">
        <property type="entry name" value="DUF3352"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11832">
        <property type="entry name" value="DUF3352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="552" mass="60894" checksum="0A6B003EC1A64461" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M5</accession>
    <name>K9Z8M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220667.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2879"/>
    <dbReference type="EnsemblBacteria" id="AFZ54945">
        <property type="protein sequence ID" value="AFZ54945"/>
        <property type="gene ID" value="Cyan10605_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2879"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3060"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703441_0_0_3"/>
    <dbReference type="OMA" id="KIVCGGT"/>
    <dbReference type="OrthoDB" id="533349at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="388" mass="43648" checksum="CA342323956859ED" modified="2013-03-06" version="1">MNEDNFFDIYHHSLNKHKEELCGDKVKFTKGESKSTIVLSDGLGSGVKANILATLTTEMLITMLDADLPLKEVIETIAGTLPRCQMRNIAYATFTIITISHHDNKFEVINFDNPPIFLLKKGRIEKLIPTTEVILDKKINYYQGVLERGDFLGAISDGILYAGLGNTMNFGWGWDNIAKFLETVFLTKASNSRKIIEQVVQETKKLYCNHIGDDATFVGVYVRKPKPLMIFTGPPLDPSKDEDYAEQLLSFAGRKIICGGTTGNIVANYMAETIDIDIATMTKELPPIGKLKEIDLVTEGILTISKAKELLNFCQFDISRLPTVRNSAVLLAKEILEADSIYFLVGQQINEFYQNPLLPKNISIRRSLIEELVQLLRENQKKVILEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M7</accession>
    <name>K9Z8M7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3518"/>
    <dbReference type="EnsemblBacteria" id="AFZ55551">
        <property type="protein sequence ID" value="AFZ55551"/>
        <property type="gene ID" value="Cyan10605_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3518"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707737_0_0_3"/>
    <dbReference type="OMA" id="RMYRWGY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="177"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="390" mass="45713" checksum="65AC46B0719FD82C" modified="2013-03-06" version="1">MAKKPTLHPHSDLKSFQRLMLLILTIINHPNLGTEEDSNTNVIHQLQEKIISIAQQYHIDIPPPAIATLRKDLETLREYNILERRMYRWGYYFGTGVMTKPEFKTAFDALESMANYQGDATAKKIYQQLEKRIRGLELKTKDDFFYPIKRNYNRAVNYTDPKEMILKGNNQKTLYHHIPSLEEAIIKGQTIEISRKKDFYNQGNIGIEIVIPIQLIYYNIAWYLVYENCANGHLIIGRLNRFSDYFQLLSPAGRNIQAQKECLKNVEQLLTNGWGLNLGNLEEQQLELKGKLTLEKIKVRFYPPISNFILEGDLRHSKQRIKVTKDNYNNQILFLDYFISLPPRSLNEFLFWLQSYGSCVEVIYPEDLRDRHKEGAIALSQRYQKLDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8N5</accession>
    <name>K9Z8N5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mg-protoporphyrin IX chelatase</fullName>
            <ecNumber evidence="6">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60492"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.6.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3028"/>
    <dbReference type="EnsemblBacteria" id="AFZ55087">
        <property type="protein sequence ID" value="AFZ55087"/>
        <property type="gene ID" value="Cyan10605_3028"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3028"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3226"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_6_2_3"/>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011776">
        <property type="entry name" value="Mg_chelatase_ATPase-dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02031">
        <property type="entry name" value="BchD-ChlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="486"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="681" mass="74789" checksum="6B4278343020437C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q0</accession>
    <name>K9Z8Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221256.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3506"/>
    <dbReference type="EnsemblBacteria" id="AFZ55539">
        <property type="protein sequence ID" value="AFZ55539"/>
        <property type="gene ID" value="Cyan10605_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3506"/>
    <dbReference type="HOGENOM" id="CLU_165559_0_0_3"/>
    <dbReference type="OMA" id="HPAFISN"/>
    <dbReference type="OrthoDB" id="1991082at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11736" checksum="FD66EAEF99662588" modified="2013-03-06" version="1">MKIDKCDRCQFYSNSPHLVCAVHPSGVDKDCLDYRLNPSYIFEEQWCPDGYVYYDGELIKLPDKPNKERQLWLLNNHPAFISNPLNCTWYNQEDVYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U5</accession>
    <name>K9Z8U5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ordered locus">Cyan10605_2710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2710"/>
    <dbReference type="EnsemblBacteria" id="AFZ54783">
        <property type="protein sequence ID" value="AFZ54783"/>
        <property type="gene ID" value="Cyan10605_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2710"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2876"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_3"/>
    <dbReference type="OMA" id="ADRFCMG"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="74"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ54783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="361" mass="39911" checksum="6B5655F8C788D9D1" modified="2013-03-06" version="1">MNRVLENKGIILVVNTVSKPKTNVSLEQWLTDLSNKIIAGYRITKKEALRLTEIEGEENILLLCEKADRIRQECCGNVVDLCSIVNVKSGNCSENCSFCSQSVHHQGKDSPIYGLKTREEILEYAKAADEAGAKRFCLVSQGRGIKYNSPKNSEFEEILATVKQIIAETNVKPCCALGEITIEQAQALKEAGVTRYNHNLESSENFYDRIVTTHTWQDRVDTVKNLKAVGIQACTGGIMGMGESWTDRIDLALSLRELEVESVPINFLNPREGTPLGEQIKLTPLEAVKAIAIFRFILPTQILRYAGGREAVLGEWQKQGLKSGINAMLIGNYLTTLGQSPEQDHAMLTELGLEGGETPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Y2</accession>
    <name>K9Z8Y2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ordered locus">Cyan10605_3000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220779.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3000"/>
    <dbReference type="EnsemblBacteria" id="AFZ55060">
        <property type="protein sequence ID" value="AFZ55060"/>
        <property type="gene ID" value="Cyan10605_3000"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3000"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3196"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_3"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="266"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="472" mass="54252" checksum="B45DE14434896B25" modified="2013-03-06" version="1">MKILFVAAEVAPIAKVGGMGDVVGSLPKILRKQGHDVRIFIPYYGFLPDKLDIPAEPIWWGDAMGQEFTVYSTLLPETDIPLYLFGHQTFARRNIYGDHDEYWRFTFFANGGAEFAWNYWKPDIVHCHDWHTGMIPVWMHETPDISTVFTIHNLAYRGPGRDLLQQITWCPEYMRGENAIAAALHFANVVNTVSPTYARQIQTPEYGEGLHELLSWINDKLIGIVNGIDTDNYNPATDRFIAQNFTIQTLDQRFRNKVKLQEESGLEINRSTFLVGMVSRLVEQKGIDLVLQIIDRFLGYTDAQMVILGTGDRNYESKLWDISNRHRGRISVQIVHNEALSRRLYSGVDAFLMPSRFEPCGLSQLLAMRYGAIPIVRKTGGLLDTVSFFDPHNEQGTGYCFDQYDALDLYTALIRAYEGYRFKKDWQKLQVRAMKQDFSWDKSAQKYIEIYKQVMPLVNISEDEKQEIAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E5</accession>
    <name>K9Z9E5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220913.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3144"/>
    <dbReference type="EnsemblBacteria" id="AFZ55195">
        <property type="protein sequence ID" value="AFZ55195"/>
        <property type="gene ID" value="Cyan10605_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3144"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043531_0_0_3"/>
    <dbReference type="OMA" id="RERFCHD"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="56085" checksum="0E6D775E2EA1AB60" modified="2013-03-06" version="1">MKIDLIGHASLLVETEDCRVLMDPVFFDPFCEGLNESCPKRTVFPEKIPDFDFLVISHQHLDHFDIRTLASLPKNVDVLIPQDKLIAESLVQLGYKSIYPLREFDKVRIGSTVLMTTRSEVRVPEFGMVFADSSGVFWNTVDTYFAPPTIQRVKKDYPHIDFLLSVWHISMEGKYQYNQSLSFPFGLYGELFHLISLIQPSAIAPGANGFKYINQSSWQNRIVFPVTRERFCRDLETAFPELKKNIYTLDPGDVFTIDQGKYSYNRGQSEYAQMILDDRECLEFSPVNVEKNLLDGNPENYDLSKMKSHIAEEIEINLLNFITEYKDLIFKEHCRWSVIYQLEVIFPDGSQKWFIDFSQDKIKVEQGRNAIANLFSYITASSLFSLIEKKRDWDYLLCSGEYRTFQKVYAINKLGIIPADASLLKDPLELRLSSQYIQGNNIKLEIEKWGNTSQDNLDTEEDINPMLRIGNLLIKKRNLKKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H2</accession>
    <name>K9Z9H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220757.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2978"/>
    <dbReference type="EnsemblBacteria" id="AFZ55038">
        <property type="protein sequence ID" value="AFZ55038"/>
        <property type="gene ID" value="Cyan10605_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2978"/>
    <dbReference type="eggNOG" id="ENOG5032T0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174883_0_0_3"/>
    <dbReference type="OMA" id="ITRQSWQ"/>
    <dbReference type="OrthoDB" id="1815845at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021492">
        <property type="entry name" value="DUF3146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11344">
        <property type="entry name" value="DUF3146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9595" checksum="B6BF2E9BA03E1179" modified="2013-03-06" version="1">MALPETIVEVKITSQSWSKGEIKGEVNAGSYQWYFKWHFPAGKLSITPTLGRSLIKEPLCRFLESHDYQLEAGGDYQFCLRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Q6</accession>
    <name>K9Z9Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Assimilatory nitrate reductase (Ferredoxin)</fullName>
            <ecNumber evidence="11">1.7.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_3269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3269"/>
    <dbReference type="EnsemblBacteria" id="AFZ55315">
        <property type="protein sequence ID" value="AFZ55315"/>
        <property type="gene ID" value="Cyan10605_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3269"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3484"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_3"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047889">
        <property type="term" value="F:ferredoxin-nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="736" mass="81982" checksum="5DDAF8313348EB09" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9U1</accession>
    <name>K9Z9U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221205.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3447"/>
    <dbReference type="EnsemblBacteria" id="AFZ55487">
        <property type="protein sequence ID" value="AFZ55487"/>
        <property type="gene ID" value="Cyan10605_3447"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3447"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3672"/>
    <dbReference type="eggNOG" id="COG3837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110331_0_0_3"/>
    <dbReference type="OMA" id="REEEWIY"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="160" mass="17996" checksum="EF5ABFFC442491E4" modified="2013-03-06" version="1">MEGKKTFILRAAEIADSIQTFSHPWNSKSEISGVYLGRTVGLKRTGVNFARIAPGKESFVYHSHYREEEWIYILSGRGIAEIDGEEFEVGSGDFMGFPTPSVPHHLRNIGDEDLVYLVGGENLEVEVADFPRLKKRMLRRGDSVEIYDTSDAKPFGVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9U8</accession>
    <name>K9Z9U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221078.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3315"/>
    <dbReference type="EnsemblBacteria" id="AFZ55360">
        <property type="protein sequence ID" value="AFZ55360"/>
        <property type="gene ID" value="Cyan10605_3315"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3315"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_6_3_3"/>
    <dbReference type="OMA" id="IWYLYAN"/>
    <dbReference type="OrthoDB" id="2066079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="137" mass="16435" checksum="664499202446A527" modified="2013-03-06" version="1">MEKIRDLLNLRIFRFLGVGGFCAGLSLIIMYVLTSIIHINYLISTVITIIVTNFIGFYLNKYYTFQTKKKLFWRELWKYYSVMLSSYILNVFAMYVLVDLVNIWYLYANILLMAILTPFNYFFHKKWSFNKKKPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Z7</accession>
    <name>K9Z9Z7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221133.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3373"/>
    <dbReference type="EnsemblBacteria" id="AFZ55415">
        <property type="protein sequence ID" value="AFZ55415"/>
        <property type="gene ID" value="Cyan10605_3373"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3373"/>
    <dbReference type="eggNOG" id="ENOG5032ZNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182970_0_0_3"/>
    <dbReference type="OrthoDB" id="1891315at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="93" mass="10389" checksum="601F50F6100DEB6C" modified="2013-03-06" version="1">MAQIKKIGSNGQISLGKEFAGQNVLIDNPEYGIWTIKIGTFIPHNEQWLLEKDNATKLDEALDWASNNQPTSTDLTELENSISSHFNSNNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA49</accession>
    <name>K9ZA49_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220951.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55233">
        <property type="protein sequence ID" value="AFZ55233"/>
        <property type="gene ID" value="Cyan10605_3184"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3184"/>
    <dbReference type="HOGENOM" id="CLU_1666496_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939162" evidence="1">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17616" checksum="6953E32755DC50AC" modified="2013-03-06" version="1" precursor="true">MVRKIPSLLLFSATCFVSFGIFSTNVEAETPSCAIASAQELEGVWESDVTQVLNKQGLLEVSGVLEIKAKTDNILEGQYTWKTKEETKTGNNSEGVKVIEDTETLYGVFNPRNCTLKMVETKESGIHEITILSQNTVEQIFRQSGEYPVVYISTLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD6</accession>
    <name>K9ZAD6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221056.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3292"/>
    <dbReference type="EnsemblBacteria" id="AFZ55338">
        <property type="protein sequence ID" value="AFZ55338"/>
        <property type="gene ID" value="Cyan10605_3292"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3292"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3507"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_3"/>
    <dbReference type="OMA" id="IMIVPMG"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1083" mass="117509" checksum="F3B9A9FB84A9AC61" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAW4</accession>
    <name>K9ZAW4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
            <plasmid evidence="5">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221246.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3493"/>
    <dbReference type="EnsemblBacteria" id="AFZ55528">
        <property type="protein sequence ID" value="AFZ55528"/>
        <property type="gene ID" value="Cyan10605_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3493"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_4_1_3"/>
    <dbReference type="OMA" id="QGKIAYT"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="34915" checksum="074C679C030F17F3" modified="2013-03-06" version="1">MASKKTPLKTSLNNRIDALFGGDNQDLQSSQRPKTMAIDVLILPEYQPRQYFDSESISQLAESIKVHGILEPLLVRPAGEGKYEVVAGGRRYRAVQLLSLTEVPVIILNLTDDEALEIAILENLQRENLNPIEETEAILKLLSGKLNQDVQEVISLLYRLRNEGKEEFKRNVSPNSEIVETVFQTVGITAKSFVETRLPLLKLPSDILSVLRQGKIAYTKAIALSKIKDEQQREKLLKDAIELNLSVRQIKARIKELNKRETKDTPSIKIDITVKQMKKKKLWETEPKKWEKVEKLLEKINLLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ83</accession>
    <name>K9YZ83_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ordered locus">Cyan10605_0048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217941.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0048"/>
    <dbReference type="EnsemblBacteria" id="AFZ52209">
        <property type="protein sequence ID" value="AFZ52209"/>
        <property type="gene ID" value="Cyan10605_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0048"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.50"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_3"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="23577" checksum="52F97872B8299E91" modified="2013-03-06" version="1">MSISTIPTQDNLQVVNPYERTASVSRTTKETDINVTVNLDGTGKCNVNTGIPFLDHMLHQLCSHGLLDLDIQATGDIEIDDHHTNEDVGITLGQAIAIAVGNRKGINRFGHFIAPLDESLIQVALDFSGRPHLSYGLDIPTQRVGNYDTQLVREFFVALVNHSQITLHIRQLDGVNSHHIIEATFKAFARAMRMALEIDPRRIHEIPSSKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ87</accession>
    <name>K9YZ87_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0053"/>
    <dbReference type="EnsemblBacteria" id="AFZ52214">
        <property type="protein sequence ID" value="AFZ52214"/>
        <property type="gene ID" value="Cyan10605_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0053"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.55"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037834_0_0_3"/>
    <dbReference type="OMA" id="RNRWAEG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="54517" checksum="F291D590E9B05800" modified="2013-03-06" version="1">MPNNHQDNYENQELDPITSFIDEFSDPEMEEEEFRSDFFQGLSGRRKKAAFALGIIWIVTVTLHLVSWSVWIIAILGIFVTIQALRLMFVASPTIKTPELEKLPYVSLMVSAKNEEAVVAKLVKMLANVDYPRHLYDFWVINDNSSDRTGIILDELKQEYPQLKVLHRDASAKGGKSGALNQAFLQTKGEIVGVFDADAIIPRDILLKTVPLFTEERIGAIQVRKSISNSNDNFWTKGQSVEMALDSYFQQQRIACGGMGELRGNGQFVRRLALESCGGWNEETITDDLDLTIRLHLDHWDIGILEHPAVEEEGVKGAIALWHQRSRWAEGGYQRYLDYWRFIISNRLNWQKKFDLLYFFMVQYIFPTAAIPDLIMVTTHHTYPLIAPLSSLTLFLAFWGMIIGLKRTNPEKEYKFADYLQLIQKSILGMIYMTHWFIVMPVTTGRMSIRQKRLKWVKTVHEGDKELAISNISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZB3</accession>
    <name>K9YZB3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52244">
        <property type="protein sequence ID" value="AFZ52244"/>
        <property type="gene ID" value="Cyan10605_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0085"/>
    <dbReference type="HOGENOM" id="CLU_3327046_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="38" mass="3987" checksum="21EC2C22BF14E78C" modified="2013-03-06" version="1" precursor="true">MMVSSSNVRKVFGGVTSLASFVGTNIAPENVMVTRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZE5</accession>
    <name>K9YZE5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(+)-abscisic acid 8'-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.14.137</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.137" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218011.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9YZE5"/>
    <dbReference type="STRING" id="755178.Cyan10605_0121"/>
    <dbReference type="EnsemblBacteria" id="AFZ52279">
        <property type="protein sequence ID" value="AFZ52279"/>
        <property type="gene ID" value="Cyan10605_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0121"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.124"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_15_6_3"/>
    <dbReference type="OMA" id="AHMCLGL"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010295">
        <property type="term" value="F:(+)-abscisic acid 8'-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="51691" checksum="D99D0A34F9A93FE6" modified="2013-03-06" version="1">MTINREKKQEYPLPPGSFGLPLMGETLSFIKDPNFGNKKEAKYGSIFKTNIIGKPTVFMVGAEANHFILQTHFDHFSWREGWPENFRTLLGESLFLQDGEIHQKNRRLLMPAFHGVALTKYFNTMKEIIDRTLKKWAEMGKLTLFPEMKEMTFEIASVLLLGSEMDNREEIKLLSQKFGELTKGLFAFPFNLPFTNYGKALKARDFLLQHIEKEIEKRKNNLKEDTISLLLQSQDEEGNRFSEAQIKVQALLMLFAGHETTTSMLTSFCMALAQNPEVREKAILEQKTLMDESDFTMEQIKKMTYLDQVLKEVERLYPPVAGGFRGVVKPFVYNGYYVPKGWQVLYRIERTHKDPNIYTEPKKFDPERFNSQRMEHKKTDFSLVGFGGGARFCLGYAFAQLEMKIFASLLLRNYHWQLEPNQDLSLDRIPSLHPRSGLKVALYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZM0</accession>
    <name>K9YZM0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218128.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52396">
        <property type="protein sequence ID" value="AFZ52396"/>
        <property type="gene ID" value="Cyan10605_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0244"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_11_0_3"/>
    <dbReference type="OMA" id="YWQEKDG"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7563" checksum="2D537B1F96BAE6A0" modified="2013-03-06" version="1">MKIEYTFWQENDGKYLGYLNEYPDYWTQGETLEDLEEHLKDLYKEFSVHFIPSIKKVALLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZS7</accession>
    <name>K9YZS7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ordered locus">Cyan10605_0269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218151.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0269"/>
    <dbReference type="EnsemblBacteria" id="AFZ52419">
        <property type="protein sequence ID" value="AFZ52419"/>
        <property type="gene ID" value="Cyan10605_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0269"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.279"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_3"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="461" mass="51944" checksum="F25B0C39F44392F5" modified="2013-03-06" version="1">MTKQQTWSDRFETSLNPIIAEFNASIGFDIELIEYDLTGSMAHAKMLGLTGIITPEEAETLIRGLSQIRQEYRDGNFNPGIEQEDVHFAVERRLTEIVGDVGKKLHTGRSRNDQVGTDIRLYLRDQIRQIQDLLREWQKALLNHAEKHIETLIPGYTHLQRAQPISLAHHLMAYCQMAQRDWERLEQIYDRTNVSPLGCGALAGTTFPIDRHFSAQELDFASIYENSLDGVSDRDFAIEFLCASSLIMVHLSRISEELILWASQEFSFITLKDNCSTGSSIMPQKKNPDIPELVRGKTGRVFGHLQALLTIMKGLPLAYNKDLQEDKEGIFDTVKTVKGSLTAMTILMSEGLEFRTQRLAEAVDEDFSNATDVADYLASKGVPFREAYNLVGKVVKTSLAANKLLKDLTLEEWKQLHPAFESDIYEAIKPKQVVSARNSYGGTGFAQIKDAIANLKEKMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z093</accession>
    <name>K9Z093_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218352.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0479"/>
    <dbReference type="EnsemblBacteria" id="AFZ52621">
        <property type="protein sequence ID" value="AFZ52621"/>
        <property type="gene ID" value="Cyan10605_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0479"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.507"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_3"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="279" mass="31174" checksum="3862A8DDCA9930A2" modified="2013-03-06" version="1" precursor="true">MINTLNKQKIILWLGIIFMILFCLAPMLWQVLTSFKTNEAIIKIPTVYFPNLEQLTLEHYFDLGFVFLRYMFNSAFVSLISTILCVVIGAPSAYALARLNLPFKNIILSLVLVVSLFPYVLLFLGLLEIVKFFNLGNNYLSLIIPYTAINLPLTILILRSFFLQLPKDLEDSARIDGYKTTSILWKIVLPLTLPALVTTGILTFIFAWNEFIFALTFITRDSLQTIPIAVAKIGGSSAFEIPYGAIASATILGTLPLIILVLTFQRRIVQGITAGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0T0</accession>
    <name>K9Z0T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217902.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0009"/>
    <dbReference type="EnsemblBacteria" id="AFZ52170">
        <property type="protein sequence ID" value="AFZ52170"/>
        <property type="gene ID" value="Cyan10605_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0009"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.10"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_2_3"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="7">
        <location>
            <begin position="486"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1056" mass="123602" checksum="38D793B1FC9DD74E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X2</accession>
    <name>K9Z0X2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Photosystem I reaction center subunit IV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psaE</name>
        <name evidence="8" type="ordered locus">Cyan10605_0233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-69</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218119.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="5/E/e=2-69"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z0X2"/>
    <dbReference type="STRING" id="755178.Cyan10605_0233"/>
    <dbReference type="EnsemblBacteria" id="AFZ52387">
        <property type="protein sequence ID" value="AFZ52387"/>
        <property type="gene ID" value="Cyan10605_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0233"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.242"/>
    <dbReference type="eggNOG" id="ENOG503313D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136462_2_1_3"/>
    <dbReference type="OMA" id="NYSGINT"/>
    <dbReference type="OrthoDB" id="1994429at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009538">
        <property type="term" value="C:photosystem I reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00613">
        <property type="entry name" value="PSI_PsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003375">
        <property type="entry name" value="PSI_PsaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34549">
        <property type="entry name" value="PTHR34549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02427">
        <property type="entry name" value="PSI_PsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="75" mass="8322" checksum="AD67EF5B4ED3E762" modified="2013-03-06" version="1">MAIQRGSKVRILRKESYWYKDVGTVASVDKSGILYPVIVRFDKVNYNGFSGSATGVNTNNFAEHELEEVAAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z100</accession>
    <name>K9Z100_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ordered locus">Cyan10605_0262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218144.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0262"/>
    <dbReference type="EnsemblBacteria" id="AFZ52412">
        <property type="protein sequence ID" value="AFZ52412"/>
        <property type="gene ID" value="Cyan10605_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0262"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.272"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_3"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="37529" checksum="409D75FAE34F4F2C" modified="2013-03-06" version="1">MPTILAVESSCDETSVAIVTNRNVIANVVASQIKLHEQYGGVVPELASRRHLEMINPCIDQAMTESGLSWSDIDAIASTVTPGLVGSLIVGVTAAKTLAMVHNKPFLGIHHLEGHIYASYLGEPSLKPPFLCLLVSGGHTSLIHVIKSGVYKTIGSTRDDAAGEAFDKVARLLNLSYPGGPIIDKLAKEGNPHAFKLPEGKVSLPNNQGYHPYDSSFSGLKTAMLRLIQGLQKENLDSLPVADLCASFQYTVAQALTKRAIRACLDLNLDTIAVGGGVAANSALRNTLQAEAQNHNLQVFFPPLKYCTDNGAMIACAGEEHFINKMRSPLSLGVSSRMNLENIEQLYSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A3</accession>
    <name>K9Z1A3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein Cyan10605_0367</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218243.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0367"/>
    <dbReference type="EnsemblBacteria" id="AFZ52512">
        <property type="protein sequence ID" value="AFZ52512"/>
        <property type="gene ID" value="Cyan10605_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0367"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.386"/>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_5_3_3"/>
    <dbReference type="OMA" id="AANRECC"/>
    <dbReference type="OrthoDB" id="1997369at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8016" checksum="014AE5572317D0AE" modified="2013-03-06" version="1">MKISVQVKPRSKKQTIEKKDNDTWIVNLKSPPVDGKANQELITVIAKQFGVKKSQVIIKSGLSSPKKIIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E2</accession>
    <name>K9Z1E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218715.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0852"/>
    <dbReference type="EnsemblBacteria" id="AFZ52984">
        <property type="protein sequence ID" value="AFZ52984"/>
        <property type="gene ID" value="Cyan10605_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0852"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.895"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_3_3"/>
    <dbReference type="OMA" id="TPDWVKH"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="488" mass="56944" checksum="59856284ABBB384C" modified="2013-03-06" version="1">MVIKTPEWVKDAVFYQIFPDRFSMGKPPQPHYNNHIKANNLESWHSQPTPQGYKGGNFWGIIDKLDYIKDLGINAIYFTPIFQSTCNHRYHTHDYYQVDPLLGGNYAFQEFLKQAHQREIKVVLDGVFNHVGRGFFFFNDILENGPFSAWLDWFKVEKWPVSAYDGSLPANYASWVGNRALPQFNHNNPQVREYIMQVAEYWLHQGIDGWRLDVPDQVKVEGFWQEFRERVKNINPEAYIVGEIWKPAEKWLDGTQFDGVMNYQFTEATLAFAGGDRILRQHVDIPPYYPYPPLNPRKYAQRIHHLLNLYDWEITLTQLNLLASHDTARLLTIAGGDIKTVEIATLLLFTFPGAPSIYYGDEVGLLGGLDPDSRRVFPPPQSWNQNLLKYHKNLIQLRHKYIALRRGNYQPLYADEHIYIFSRKYSEETIIVIINIDTQPRNITLNLCNFPIKINEKIFGDSTFIYEQIDGKENIVFNLLPRSGSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K0</accession>
    <name>K9Z1K0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4346 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218187.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0307"/>
    <dbReference type="EnsemblBacteria" id="AFZ52455">
        <property type="protein sequence ID" value="AFZ52455"/>
        <property type="gene ID" value="Cyan10605_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0307"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.319"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152500_0_0_3"/>
    <dbReference type="OMA" id="GLICAKH"/>
    <dbReference type="OrthoDB" id="1619705at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025595">
        <property type="entry name" value="DUF4346"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017260">
        <property type="entry name" value="UCP037673"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14251">
        <property type="entry name" value="DUF4346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037673">
        <property type="entry name" value="UCP037673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4346" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="14142" checksum="474CD6EC4795BB2C" modified="2013-03-06" version="1">MSTTLSSSLTELDNQLSNRHIDLDPQGYFIIYLNKDAGLICADHYTNAINDQGLAVDPDTGEVIACKGGKVRKPTTTFTGRTAKEICVKLLEENANPPVSMLDHAAYLGREFMRAEYALQTGKEYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L2</accession>
    <name>K9Z1L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218827.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0966"/>
    <dbReference type="EnsemblBacteria" id="AFZ53096">
        <property type="protein sequence ID" value="AFZ53096"/>
        <property type="gene ID" value="Cyan10605_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0966"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1020"/>
    <dbReference type="eggNOG" id="ENOG5031CJR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147452_0_0_3"/>
    <dbReference type="OMA" id="FMAQMTV"/>
    <dbReference type="OrthoDB" id="1739713at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014954">
        <property type="entry name" value="DUF1825"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08855">
        <property type="entry name" value="DUF1825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="12621" checksum="33DA41199B52B48B" modified="2013-03-06" version="1">MGFFDSEVVQQEAKQLFEDYQSLMKLGGEFGKFDREGKKIFIEKMENMMERYRIFMKRFELSEDFMAKMTVEQLKTQLSQFGTTPDQMFQQMHMTLERMKQEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N7</accession>
    <name>K9Z1N7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52268">
        <property type="protein sequence ID" value="AFZ52268"/>
        <property type="gene ID" value="Cyan10605_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0109"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.112"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030246_1_0_3"/>
    <dbReference type="OMA" id="INVSMEP"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="490" mass="54954" checksum="65989DA69D638802" modified="2013-03-06" version="1">MTIINYTLFTNCPSRSKGDVIMLKNETFMSTEKVSDNQQTSENYQQVNQHRPQFSFRQILNMNLGFLGIQFAWGLQMANMSAIFEYLGADAHQLPILWIAAPLTGLLVQPIIGNLSDYTWTPLGRRRPYFLGGAVLGAIALLFMPHSPSIWVAAILLWLLDSSANISMVPFRAFVGDLLPQDQRTKGFAIQSVMVGMGAISASALPWILSHFFQIDNTTNALHQIPLTVEYSFYTGAILFLGTVIWTVITTPEYPPQNLEKFERLQEQRGGIMSSIRESWQSLQNMPSTMTYLAKIQFFTWLGIFCFFLYFPPAVARNIFGATNQGSLLYSDGIEWAGVCFALFNGVCVIFSFLLPNFAKKIGRQTIHCLCLFCGGISLIALLFIHDKYILLFSMFGFGIAWASALVMPYAMLTESIPPQRRGIYQGIFNFFIVLPEIAVSLFFGWIMNYFLHDNHLLAVVLGGVFLIIGAGFTLPRVEGLKAIFPQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T9</accession>
    <name>K9Z1T9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glyoxalase II</fullName>
            <shortName evidence="5">Glx II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gloB</name>
        <name evidence="7" type="ordered locus">Cyan10605_0406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218281.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0406"/>
    <dbReference type="EnsemblBacteria" id="AFZ52550">
        <property type="protein sequence ID" value="AFZ52550"/>
        <property type="gene ID" value="Cyan10605_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0406"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.429"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_4_1_3"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="29029" checksum="EEF7EA40A010B71E" modified="2013-03-06" version="1">MDIIRIPVLSDNYVFLIYDRNTNEIAVVDPAVSEPVLAEIGKLGGKLTAILNTHHHLDHVGGNKELLQHFPEAIVYGGKKDKGRIPRQDVFLEDGDAIEFSGRKAHVYFVPGHTFAHIAYYFPPINESESGELFCGDTLFAGGCGRLFEGTPANMVDSLSKLRQLPESTRVWCAHEYTLSNLKFALTVDQDNPHLHKRYKDVQEARENNVATVPSTIGMEKLTNPFMRWDDPKIKSLMGFEEPERVFARLRGMKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W4</accession>
    <name>K9Z1W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218105.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0219"/>
    <dbReference type="EnsemblBacteria" id="AFZ52373">
        <property type="protein sequence ID" value="AFZ52373"/>
        <property type="gene ID" value="Cyan10605_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0219"/>
    <dbReference type="eggNOG" id="ENOG5032TZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192802_0_0_3"/>
    <dbReference type="OMA" id="IAWFEKD"/>
    <dbReference type="OrthoDB" id="1884316at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9280" checksum="6BD4BFC63D070A47" modified="2013-03-06" version="1">MLNNQQFLTQEESLAVEASLLTSEEKFLTRLTISSLRVLQLIAQDLDVSVDSLSSEQIIAWMEKDSKVRREQGIDKAILKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y2</accession>
    <name>K9Z1Y2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0583"/>
    <dbReference type="EnsemblBacteria" id="AFZ52722">
        <property type="protein sequence ID" value="AFZ52722"/>
        <property type="gene ID" value="Cyan10605_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0583"/>
    <dbReference type="HOGENOM" id="CLU_3389012_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="32" mass="3765" checksum="E721D03B2A7B5268" modified="2013-03-06" version="1">MTSQKKVLNDLQKLTDETEYLLQSEANKNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y7</accession>
    <name>K9Z1Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U61 LD-carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218336.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0463"/>
    <dbReference type="EnsemblBacteria" id="AFZ52605">
        <property type="protein sequence ID" value="AFZ52605"/>
        <property type="gene ID" value="Cyan10605_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0463"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.490"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_3"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="33217" checksum="B9C51BEF0F41F8F9" modified="2013-03-06" version="1">MFVPPPLHKGDTLIAIAPSGTLREREKERFEEGLKIWQERGYEIVLEENYEAREGYLAGNDAIRRQALEVAWTNPEYKGIICVRGGYGGARLLENWQWAKINPPKWFIGFSDVTSLLWSLYNENIISLHGPVLTTIAQESQWSIERLFNYIEGEKLPELQGKGWGGKKATGRLLPANLTVATHLLCTPVCPKFNDVILALEDVQEAPYKIDRMITQWRLMGILDKVKGVILGRFSGCDAPESIPSWTVEQVWCDRLQGLEIPIISNLPFGHDGDNACLPVGGKVEIDGETGILSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z202</accession>
    <name>K9Z202_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218478.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0608"/>
    <dbReference type="EnsemblBacteria" id="AFZ52747">
        <property type="protein sequence ID" value="AFZ52747"/>
        <property type="gene ID" value="Cyan10605_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0608"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.641"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_0_3"/>
    <dbReference type="OMA" id="QVKILAW"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="334" mass="36721" checksum="89087CA40CAD9365" modified="2013-03-06" version="1">MRIGINGFGRIGRLALRAGWGNPNLEFVHINELKGGVETAAHLLEFDSVHGRWHKSPTIEHEKICIDGKYISFSSYSTPQEVPWQDLGVDLVIESSGKFRTPDTLNPYFENGVKKVVVAAPVKENALNVVVGVNDHLYNPEKHHLLTAASCTTNCLAPVVKVIHEGLGIKHGVITTIHDVTNTQTVVDAPHKDLRRARSCLQSLVPTTTGSATAIALIYPELQGKLNGIAVRVPMLNASLTDCVFEVNRKTTVAEVNQLLKEASETAPLKGILGYEERPLVSIDYKDDARSSIIDALSTMVIDDTQVKILAWYDNEWGYSNRLIELVNKIAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z235</accession>
    <name>K9Z235_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ordered locus">Cyan10605_0508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218381.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0508"/>
    <dbReference type="EnsemblBacteria" id="AFZ52650">
        <property type="protein sequence ID" value="AFZ52650"/>
        <property type="gene ID" value="Cyan10605_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0508"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.538"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_3"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="157" mass="16708" checksum="D774EE416D307335" modified="2013-03-06" version="1">MKLHQIAPNPKSKKRRRRIGRGISAGQGASGGFGMRGQKSRSGTGTKPGFEGGQMPLYRRVPKLKHFKIINPKHFTIINVEKLANLAPNTEVTLESLMEHGIVTANDGPLKILGNGELNVALNVKAAAWSKSAQAKIEAAGGSITSTTPKTESGNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z294</accession>
    <name>K9Z294_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218244.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0368"/>
    <dbReference type="EnsemblBacteria" id="AFZ52513">
        <property type="protein sequence ID" value="AFZ52513"/>
        <property type="gene ID" value="Cyan10605_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0368"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_6_1_3"/>
    <dbReference type="OMA" id="SHLCRRI"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="26477" checksum="B36FB7803E5B5283" modified="2013-03-06" version="1">MTIEISEILDQYKHGVRDFQGIKFIEGEILKEDLREIDFSGADFRQTRLGLSNFSHSNFSGANLSEAILWGTDLSHSNLSKTILRDADLSNAHLQGVNLHNANIIKTMFCGANLQKADFSNVIAVDADFRFSYDHRTDLTEAIFKDALLCYANFSQALLYKANFDGAKLCRSHLCRRIDNDEVLTDLTSASFRNADISYADFTGAILINADLTGADITGTIFDDAILHGAIMPDGSIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F9</accession>
    <name>K9Z2F9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219115.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1270"/>
    <dbReference type="EnsemblBacteria" id="AFZ53386">
        <property type="protein sequence ID" value="AFZ53386"/>
        <property type="gene ID" value="Cyan10605_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1270"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1341"/>
    <dbReference type="eggNOG" id="ENOG502ZBNS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1365635_0_0_3"/>
    <dbReference type="OMA" id="FDVGWEP"/>
    <dbReference type="OrthoDB" id="1481554at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26589" checksum="862A8E71191A8063" modified="2013-03-06" version="1" precursor="true">MRNRRARKISNPSQNLDSFLDILTNTVGVLMFIGLFVSLLAVEAGTIIRTPLRSETNKIPNFFEVRDNKIFYVSDPQISQEIDEVVTTLPRCSDPNIPNDIPDYLYSFYLQEIQEYQACVNSREQKLKNFYYSNQDYQVTISEQGSIIYQPVATSSGENKKELMATDSDYGTILKQLDPQINYVAFLVRPDSFEAFRVARQKARSMGYEVGWIPFTEDRVISFGSGGRSVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H5</accession>
    <name>K9Z2H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribodipyrimidine photolyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218314.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0439"/>
    <dbReference type="EnsemblBacteria" id="AFZ52583">
        <property type="protein sequence ID" value="AFZ52583"/>
        <property type="gene ID" value="Cyan10605_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0439"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.464"/>
    <dbReference type="eggNOG" id="COG3046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_3"/>
    <dbReference type="OMA" id="GMSQYAD"/>
    <dbReference type="OrthoDB" id="215545at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="500" mass="59361" checksum="1CD032D1792A7F0E" modified="2013-03-06" version="1">MTIGVWILGDQLIENHPILAELEANKKEVIVILIESLNHIKKRNYHQQKLIFIWSAMRHYAEELRINNWQINYQIVENFDEGLFNTIQKYSLTEIRTITPCDRTFLQSIKNLKLNCEVKLYPNPNFLWQPEEFKQWADKRKRLILEDFYRESRKRWQILLTENNQPVGGKWNLDKENRKPPKNNLSPPQPLVFKLDNITKKVIEKVNKLDIKTYGNSDKFNWAVTRKDALKVLDNFINYRLEKFGTYQDAMITNQEFMWHSLISPYLNVGLLQPLEVIKTVERAYYEKSFPLNSVEGFIRQILGWREYMYGIYHYVEEDYFQANWFNHQHPLPSFFWDSNQAKMNCLKQVLKQTENTGYAHHIQRLMIISNYALIKGISPQEIENWFHSAYIDAYDWVMQTNVLGMGQFADGGLLASKPYASSANYINKMSDYCSNCSYNPKEKTTENACPFNYLYWDFLARHEEKLRSQGRMNLVLKHLEKMSPDELNKIHNLASSTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H9</accession>
    <name>K9Z2H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218668.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0804"/>
    <dbReference type="EnsemblBacteria" id="AFZ52937">
        <property type="protein sequence ID" value="AFZ52937"/>
        <property type="gene ID" value="Cyan10605_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0804"/>
    <dbReference type="HOGENOM" id="CLU_165358_0_0_3"/>
    <dbReference type="OMA" id="YYRYQIL"/>
    <dbReference type="OrthoDB" id="1969510at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="13513" checksum="BAACC414287E088C" modified="2013-03-06" version="1" precursor="true">MNIWLSLLLSLLLTSLVSFALPIVLFTVVLAILGVMGHFPLISPFINYAYAQIWHFLATFGEGSGIFGILIIAVTCAIAGLLFESLNFYRYRLLINKPLKPLWQKPKTAEIISKIICSNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I7</accession>
    <name>K9Z2I7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ordered locus">Cyan10605_1246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219093.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z2I7"/>
    <dbReference type="STRING" id="755178.Cyan10605_1246"/>
    <dbReference type="EnsemblBacteria" id="AFZ53364">
        <property type="protein sequence ID" value="AFZ53364"/>
        <property type="gene ID" value="Cyan10605_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1246"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1314"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_3"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="32860" checksum="FBE59A60AE743A77" modified="2013-03-06" version="1">MKNSLGNRIGVFDSGVGGLTVLRKLYRYLPQESILYFADTLRLPYGTRTKEEIILFVRQILDWMQSEGVKMVIMACNTSSALALETVQSEYDFPILGLIHPGAKGAVKAGKRVGVISTVATAKSNAYRDAIAEINPNTQVWQMGCPEFVPLIEQNRIYDPYTKKVAQQYLKPLIEANIDTLIYGCTHYPHLKGVLSEILPSSVRFIDPADYVVRAAEKELELMNLRNHGLLLPTRFCVSGNSDDFAITSKQWLGFTPHVEKIHLPSSKVIELHNNSTEIEINQHHLYAESLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K4</accession>
    <name>K9Z2K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219160.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1316"/>
    <dbReference type="EnsemblBacteria" id="AFZ53431">
        <property type="protein sequence ID" value="AFZ53431"/>
        <property type="gene ID" value="Cyan10605_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1316"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1389"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_45_1_3"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="25005" checksum="84588D6992A313BE" modified="2013-03-06" version="1">MPTQTFFNLPEAKQQIIIEKSLEQFANHSYEAVSISRIVQEARIAKGSFYQYFEGKEDLYLYLVDIGIARQKSFIENADLPPIENGFFPYLRSLLKTSLDFQLSHPHFTQILFRLPNYGDIPFRDEVFHRTKAVSIAFIKEKIEYAIALGQLPKYLNPDMVAFMIVTLGNELRQFIPRHLGIKVEKLVKEDTPLDVNAINQTLDDFVSTLEKGIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2P0</accession>
    <name>K9Z2P0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219200.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1357"/>
    <dbReference type="EnsemblBacteria" id="AFZ53471">
        <property type="protein sequence ID" value="AFZ53471"/>
        <property type="gene ID" value="Cyan10605_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1357"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1431"/>
    <dbReference type="eggNOG" id="COG0027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184088_0_0_3"/>
    <dbReference type="OMA" id="YCPLTIQ"/>
    <dbReference type="OrthoDB" id="1482164at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="237" mass="27131" checksum="7096717FC1B209B8" modified="2013-03-06" version="1">MSKVIIIVNAQVEGGKISPNAPVAERMARALARGVTKSNPHSEIEIVSGADLWSKSLQLLSPSSNLVYCPLTIKLPDWFVFPAQKIYFACRELEKRRQWVEKNFGYHTSQDNQYLGDLWLPIIFTHEQLIYGSVISEGMIPNDYQQPCHLSPDIFRKLCHLAENLLDSIEAIPSVYLLQFRLLEQQIIFDRLWPFPATPAIASIGTQEPDLFTCHWYCLSHQPLSEIIYPSMVMKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2S6</accession>
    <name>K9Z2S6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218758.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0897"/>
    <dbReference type="EnsemblBacteria" id="AFZ53027">
        <property type="protein sequence ID" value="AFZ53027"/>
        <property type="gene ID" value="Cyan10605_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0897"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_21_1_3"/>
    <dbReference type="OMA" id="WGLFGGH"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17338" checksum="6B6875E200DA7F6C" modified="2013-03-06" version="1">MISPVKEVAIAILYRENKFLLQLRDNIPTIIHPGCWALFGGHLETGETPESALIREIQEEIDYQITDFHKFICHQEGNIIRHVYYAPLKVEIKQLTLKEGWDFTLAPPETILQGQCYSKIAKQMRFFAPFHRQILLDFYQIHFPLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T2</accession>
    <name>K9Z2T2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219245.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1404"/>
    <dbReference type="EnsemblBacteria" id="AFZ53516">
        <property type="protein sequence ID" value="AFZ53516"/>
        <property type="gene ID" value="Cyan10605_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1404"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1483"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_2_3"/>
    <dbReference type="OMA" id="NQKDYVH"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="42222" checksum="766490A07E3EFB27" modified="2013-03-06" version="1">MSEKKLGVAIVGTGFGKQIHLPAFQLHPRTEVVAIHHRVLDKAKAIASEYNIAHAMDDLEDICRLPEVDIVSISTPPFLHYDMAKIALNHDKHILLEKPLNLNVYETREIYRLAKQKQKIVVPDFEFRFIPAWQLLKEYLDNDYVGKTRLIKIDWLVASRGNPNRAWNWYSVKERGGGALGAIGSHAFDYIHWLFGEIATISAYLGCAISQRPDPLSNNQLKPVTADDTCLITLELNDGTPVQVNLSSVTYQGRGHWLEIYGEKGTLVLGSDNLKDYVHGFKLYASRDNQPLEEIKIPERLAFPQVFDDGRLAPFIRVVNQLVENIDHNKMNAPSIIEGIYSQLLMDLTHKSHTQKQRLKVPSLQDFLLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U3</accession>
    <name>K9Z2U3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="6" type="synonym">atpD</name>
        <name evidence="8" type="ordered locus">Cyan10605_0767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218631.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0767"/>
    <dbReference type="EnsemblBacteria" id="AFZ52900">
        <property type="protein sequence ID" value="AFZ52900"/>
        <property type="gene ID" value="Cyan10605_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0767"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.808"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_4_0_3"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="184" mass="20663" checksum="9BEC1691CF2A2B1C" modified="2013-03-06" version="1">MQSAITAEVVEPYAEALMSLTKSEDITDEVAYSVRELKNLFEDSDDLRIFFASPLVSVEDKKEVIRKIAEGQVHPFLLNFLLLLVDRKRIRFVEGIFSKYLEIVRQLNNVVLAEVTSAVRLYEGEAEKLVEKIKQLTGASDVEIQTKIDPDIIGGVIIKVGSQVYDASLKGQLRRISFSMLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z349</accession>
    <name>K9Z349_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribulose bisphosphate carboxylase large chain</fullName>
            <shortName evidence="11">RuBisCO large subunit</shortName>
            <ecNumber evidence="11">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbbL</name>
        <name evidence="11" type="synonym">rbcL</name>
        <name evidence="14" type="ordered locus">Cyan10605_0644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexadecamer of 8 large chains and 8 small chains; disulfide-linked. The disulfide link is formed within the large subunit homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The disulfide bond which can form in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RuBisCO large chain family. Type I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218514.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0644"/>
    <dbReference type="EnsemblBacteria" id="AFZ52783">
        <property type="protein sequence ID" value="AFZ52783"/>
        <property type="gene ID" value="Cyan10605_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0644"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.680"/>
    <dbReference type="eggNOG" id="COG1850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031450_2_0_3"/>
    <dbReference type="OMA" id="IHGHPDG"/>
    <dbReference type="OrthoDB" id="848380at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08212">
        <property type="entry name" value="RuBisCO_large_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01338">
        <property type="entry name" value="RuBisCO_L_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020878">
        <property type="entry name" value="RuBisCo_large_chain_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020888">
        <property type="entry name" value="RuBisCO_lsuI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00157">
        <property type="entry name" value="RUBISCO_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="2 11" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="8 11" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="9 11" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="11" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="13">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="12">
        <location>
            <begin position="147"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" description="in homodimeric partner" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain; in linked form" evidence="11">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="468" mass="52005" checksum="C6002D758ABF66F5" modified="2013-03-06" version="1">MAQAGFKAGVQDYRLTYYTPDYTPKDTDLLACFRMTPQPGVPPEECAAAVAAESSTGTWTTVWTDGLTDLDRYKGRCYSVEPVPGEDNQYFCFVAYPLDLFEEGSITNVLTSLVGNVFGFKALRALRLEDIRFPVALIKTYQGPPHGITVERDLLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFMRWRDRFLFVQEAIEKAQAETNEIKGHYLNVTAGTCEEMLKRAEFAKEIGTPIIMHDFLTGGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDRAATLGFVDLMREDYVEEDRSRGVFFTQDYASLPGTMPVASGGIHVWHMPALVEIFGDDSCLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRSLAREGNEVIREACRWSPELAAACELWKEIKFEFDTVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z353</accession>
    <name>K9Z353_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1473"/>
    <dbReference type="EnsemblBacteria" id="AFZ53584">
        <property type="protein sequence ID" value="AFZ53584"/>
        <property type="gene ID" value="Cyan10605_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1473"/>
    <dbReference type="HOGENOM" id="CLU_3097933_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="51" mass="5832" checksum="F064841EA9A4F8D4" modified="2013-03-06" version="1">MLNNLVNKLPEIQDLLKAVTTENKTFSFDALHYQKQTIKIILETATEVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z398</accession>
    <name>K9Z398_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ordered locus">Cyan10605_1063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218918.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1063"/>
    <dbReference type="EnsemblBacteria" id="AFZ53187">
        <property type="protein sequence ID" value="AFZ53187"/>
        <property type="gene ID" value="Cyan10605_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1063"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1125"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_5_2_3"/>
    <dbReference type="OMA" id="ILYPMRI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="172" mass="19818" checksum="45C2AC838F1ADFD2" modified="2013-03-06" version="1">MIKEILQIGEPVLREIAQEVEDIHCQETQNLIDELLDLTLKSHGVGIAAPQVGISKRIIVVASHPNIRYPDAPYMSPFAMINPLIVSHSQEIVIKEEGCLSVRQKRGMVARYRDIEVEYFTRDGQWHRKQYNNFIARIIQHELDHLNGILFVDHLQEDLMSEAQLKLDKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C7</accession>
    <name>K9Z3C7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="4" type="synonym">rpl35</name>
        <name evidence="6" type="ordered locus">Cyan10605_1577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219413.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1577"/>
    <dbReference type="EnsemblBacteria" id="AFZ53686">
        <property type="protein sequence ID" value="AFZ53686"/>
        <property type="gene ID" value="Cyan10605_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1577"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1674"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_3"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="8184" checksum="73BD9F3E1B27D750" modified="2013-03-06" version="1">MPKVKTKKSAAKRFRVTGSGKKIFRRKANKNHLLEHKTAEQKRRRLSNLTLVHENDVKEVRLMLPYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E9</accession>
    <name>K9Z3E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219438.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1603"/>
    <dbReference type="EnsemblBacteria" id="AFZ53711">
        <property type="protein sequence ID" value="AFZ53711"/>
        <property type="gene ID" value="Cyan10605_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1603"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096499_0_0_3"/>
    <dbReference type="OMA" id="WKVQEDF"/>
    <dbReference type="OrthoDB" id="1807583at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018971">
        <property type="entry name" value="DUF1997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09366">
        <property type="entry name" value="DUF1997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26980" checksum="34080093E920D30A" modified="2013-03-06" version="1">MPEDRENQDKEIKENQPITFQTHFTGIMEMYSDSETVCNYLNDHRGWFVRCAEPMKAIPYGENGYTLIIGHYGAFGYNVEPQMSVILEPPIENHYTMYSISNPEFNHSGYQVNYRSEMTINPIPITSAAKGIEKAYHRHKISPPEIITCINWCLDLFVTVSFPPFIYKLPMSVIYDTGDRLLRQIVKQVSPRLSYKVQKDFHSRFNLPIPPANARTCQPLQTPDKVEIINNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I9</accession>
    <name>K9Z3I9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219416.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1580"/>
    <dbReference type="EnsemblBacteria" id="AFZ53689">
        <property type="protein sequence ID" value="AFZ53689"/>
        <property type="gene ID" value="Cyan10605_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1580"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1677"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_10_0_3"/>
    <dbReference type="OMA" id="YFGFCGG"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026357">
        <property type="entry name" value="rSAM/SPASM_prot_GRRM_system"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04261">
        <property type="entry name" value="rSAM_GlyRichRpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="397" mass="45861" checksum="1F60B82A5A07B30E" modified="2013-03-06" version="1">MLTSQEKTNYLRSENQEFGPISLVVIQPNSFCNLDCDYCYLPDRNLKNKLSLDLIEPIFKSIFTSPFCRDSFTICWHAGEPLTMPISFYKSAFEIIENTSKKYNQTELSFNYSYQTNGTLITQAWCDFWQQYPVSIGVSIDGPAFLHDAHRKNRKGGNSHELTMRGIKYLQKNNIPYNTISVITKDSLDYPDEMFNFFAENEIYDLAFNMEETEGVNDSSSLNGSEVEKKYRYFIERFWQLITESKLPFFIREFETLISLIYHQKRLNHTEMNHPFSIINIDYQGNFSTFDPELLSVKTPEYGDFIFGNILTDSLESICETEKFKGIYQEMKTGVKLCAENCHYFGLCGGGAGSNKYWENGTFASSETQTCRYRIQILTDVVLDAIEQSLGVTANNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P3</accession>
    <name>K9Z3P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218911.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53180">
        <property type="protein sequence ID" value="AFZ53180"/>
        <property type="gene ID" value="Cyan10605_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1054"/>
    <dbReference type="HOGENOM" id="CLU_2715616_0_0_3"/>
    <dbReference type="OrthoDB" id="2216021at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8645" checksum="7AF3AAF62B078437" modified="2013-03-06" version="1" precursor="true">MSKLLISLLFFTGLIFNFTLSISPVFSHEGYSHFREKYKSPYEINNNRFTKDNDDKKEEKDKEEDHKGHHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W2</accession>
    <name>K9Z3W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Processing peptidase</fullName>
            <ecNumber evidence="3">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.64" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218799.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0938"/>
    <dbReference type="EnsemblBacteria" id="AFZ53068">
        <property type="protein sequence ID" value="AFZ53068"/>
        <property type="gene ID" value="Cyan10605_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0938"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_1_3"/>
    <dbReference type="OMA" id="WAFPAPE"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="175"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="47383" checksum="DBA4C24575DD6C4C" modified="2013-03-06" version="1">MTQTQKYIHKTILSNGITLVVTENPTTDIIAGKIFCRQAGSLWEAKHQAGLFHLLASVMAKGTRNLSSLEIAEKVESIGAALGTDTSSDYFLVSMKTITEDFPEIMALASEILRFPSFPLDEIALEKNITIQNIVSQKEQPFNVAFSQLRQMIYGQHPYGFSLLGTEETVANLIQDDLRFYHQQHFRPDRLVISLAGNIDLNSAVEVVEKVFGDWFPPEDALIKIDSLEQRELLSPKARSHHTSQDTQQSIIMMGYLVPEMTHPDYPVLKLLSTYLGNGLSSRLFVELREKRGLAYDVSAFYPTRVDKSQFVVYMGTAPHNADIAQEGLYNEIKRLRENPLTTEEIQTAKNKLLGQYALSKQTNGEFAQVFGWYETLGLGIEYDNIFPQKISSVTIEDIQRVAQEYLQDQFLCVSKVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z410</accession>
    <name>K9Z410_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1772"/>
    <dbReference type="EnsemblBacteria" id="AFZ53874">
        <property type="protein sequence ID" value="AFZ53874"/>
        <property type="gene ID" value="Cyan10605_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1772"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1881"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_0_2_3"/>
    <dbReference type="OMA" id="LEGVYWD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="PTHR42896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="29265" checksum="EDCD659A78A96A9C" modified="2013-03-06" version="1">MIFTGGINFMNLKAIIFDVDGTIAETERDGHRIAFNRAFERENLSWHWDVDLYGELLEIGGGKERIRYYISNYLPSFNINQSLDEFIAHLHLLKSRYYRQLLENNSIPLRLGVKRLIQEAYSQGVKVAIASTASVANVEALLETSLGNPMASWFEVIAAGDMVERKKPAPDIYLLALEKLNLSPHECIAIEDTNQGLTAAVKAGLKTVVTVNQYTEKQNFDEAILVLNHLGEKDLPFRVIQGENYGEKYFNLSLAEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z443</accession>
    <name>K9Z443_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Primase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219631.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1802"/>
    <dbReference type="EnsemblBacteria" id="AFZ53904">
        <property type="protein sequence ID" value="AFZ53904"/>
        <property type="gene ID" value="Cyan10605_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1802"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805901_0_0_3"/>
    <dbReference type="OMA" id="AQPEINE"/>
    <dbReference type="OrthoDB" id="382302at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014819">
        <property type="entry name" value="PriCT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08707">
        <property type="entry name" value="PriCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="33"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PriCT_2" evidence="1">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="39631" checksum="8EFB3D11D47AF834" modified="2013-03-06" version="1" precursor="true">MTKNNSFSLTELFSSDRFAVCRDKEYYEKSWQKGKSYDYCQKQLKIGKPNGYGLLTGEFNGVGIVSIDFDGDSADQVAKAIGSWLLNQDSMCWSSGKKGHYQIAYQIPTEHLALWQHISKYDLTKYKNYSAINGDHLEIRYKGCASVLPPSVHPETGYYKWIKEISPRCLSFQESYDLLNTCLIFIKDNDLSPQDELRLIETALSHILSDDYHQWVTVGMALYNHGVDFDIWDKWSATSAKYDGKGIEKKWDSFKKGYKVGIGTLFYLAKNNGFNQSQWMRENLKRNVKILSKTYEKSGNDINENNVPFLFEQLVNKLAQPEINESQRFLEIGQFCTQYKVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H3</accession>
    <name>K9Z4H3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219764.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1943"/>
    <dbReference type="EnsemblBacteria" id="AFZ54039">
        <property type="protein sequence ID" value="AFZ54039"/>
        <property type="gene ID" value="Cyan10605_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1943"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2065"/>
    <dbReference type="eggNOG" id="COG4121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061971_0_1_3"/>
    <dbReference type="OMA" id="ICYGLGY"/>
    <dbReference type="OrthoDB" id="864499at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_30" evidence="1">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33915" checksum="B8F18F77B7128601" modified="2013-03-06" version="1">MTSFETRITEDGSKTFYSSEFGETFHTKYGAKTEAEITYIKGCQIPEKIKYQNHLRILDICFGLGYNTAAAIDYILKENPQCFIEIIGLELDENVPIQALNNNLLNDWQPTIVDILQELIINKQVISPNFKLSLLIGDARDAIASLVEQNWQGDAIFLDPFSPPKCPQLWTVEFLSLVAKCLNQEGILATYSCSAAVRTALQLAGLKLGANFCIGRRSPGTLASYNERILPPLSLMELEHLQTRASIPFRDLSLRDTAEIIKKRREKEQLLSNLESTSKWKKRWFNPKKLRKLTDDNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P1</accession>
    <name>K9Z4P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219834.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2015"/>
    <dbReference type="EnsemblBacteria" id="AFZ54109">
        <property type="protein sequence ID" value="AFZ54109"/>
        <property type="gene ID" value="Cyan10605_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2015"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2141"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="ESADCHH"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38381" checksum="4929FCC6B6FBAC2E" modified="2013-03-06" version="1">MTINLSSLDFWDLLENYTLAENPQSFNDENTEITMLYPPLLGEGYKQHIWLNSGIKLTIHSYQLNQDLIIDNSNEETDCIEFAFKLKSDCQINNHYFNFNKYSYIIGKHRQGAIVKYQGNSVNKGVDIHLDMNKFSDFLENSYEQNFPPCLKSILSQEQKNFSLSYPLKFSSAIELVIKQIINCPYQGLIKNIYLEGKSLELIALYFDLLTKCDRPYFSQTSSFNSSDVEAIYQAKEIIEKNFDNPPTLSDLAQQVRLSNRKLEQGFHQVFNTTVFGYLRQYRLKIAGELLREKKTNISLISSLVGYSSHSAFTKAFQKQFGVTPKIYQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P7</accession>
    <name>K9Z4P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219289.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1449"/>
    <dbReference type="EnsemblBacteria" id="AFZ53560">
        <property type="protein sequence ID" value="AFZ53560"/>
        <property type="gene ID" value="Cyan10605_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1449"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1537"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054193_6_1_3"/>
    <dbReference type="OMA" id="PGYSEHS"/>
    <dbReference type="OrthoDB" id="1593541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="109"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="29274" checksum="44BF5D9FC61B6D6C" modified="2013-03-06" version="1" precursor="true">MDEIPVAQRKVNTTPQNKPFPFSIFLALGSAIITMSLFWLFSQTLSSQSQQQDTPSVTASETVSDNIPTTENNPPSSDTVEIPENILGHLGYEQAPMSELKPVTADGRIKLRTKAAEKFLEMQSDARREGITLVAISGFRTIDDQEYLFFNIKEQRKQETSKRAEVSAPPGYSEHHTGYAVDIGDGNAPATNLNTNFEQTAAFRWLEANAAKYSFELSFPEDNLQGISYEPWHWRFVGDTHSLETFYKARELKTNLQPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q0</accession>
    <name>K9Z4Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219844.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2028"/>
    <dbReference type="EnsemblBacteria" id="AFZ54119">
        <property type="protein sequence ID" value="AFZ54119"/>
        <property type="gene ID" value="Cyan10605_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2028"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_3"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="438" mass="49114" checksum="B4B9D2AE62D5593D" modified="2013-03-06" version="1">MKNNSIYSFIILWLGQSFSLIGSRITTFALIFWTWDSTSQASSLSLLWFFQQLPQIFVAPLAGYLVDRCDVKGTLRTRKLLMILGDLVAVLSTIFLLFQQLNQQLTITDLYITTFINNCFGSIQELAYTTTIPLMIPSHQFDRANSLEFLSGYGSRIIAPAMAGILYPLINLQGILMVDIGTFFLALITIYFVQIPSSNNHKNRENLVTSNYHKNAILFTEIKSSYQYIKNNKLLKNLLIITCLFQFFHDLGDSIYAPLILARTNNDQIIYSHIATSAGIGGVIGALFIVTKGGFSHPMKGVFIGMIGAGVSKIVFGFSNVYFIWIIAQFFSSFHFPILGSAETTIWLRETPLNSQGKILAFQRMGILIFSLIAYSLGGFLADYFFVPLMTQENIFSFVFGMGKSAGISLLYTLSAIALFLIGLWSWYLSTKNNQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z502</accession>
    <name>K9Z502_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="5 8">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="5 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2115"/>
    <dbReference type="EnsemblBacteria" id="AFZ54204">
        <property type="protein sequence ID" value="AFZ54204"/>
        <property type="gene ID" value="Cyan10605_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2115"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2248"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_3"/>
    <dbReference type="OMA" id="IHHYMGT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase NAD activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase NADP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006069">
        <property type="term" value="P:ethanol oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="9">
        <location>
            <begin position="41"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="398" mass="42723" checksum="29065016398B671E" modified="2013-03-06" version="1">MNFSLKTSEISHFLGNNEKEKINNQILRVMKVKAAVALEAGKPLTIETVDLQPPQAGEVLVEIKATGVCHTDAYTLSGKDPEGLFPSILGHEGAGVVVEVGKNVKSLKVGDCVIPLYIPECRECEYCLSFKTNLCQAIRVTQGKGVMPDGTSRFSLDGKPLYHYMGTSTFANYTVVPEIALAKIPSDVPFEKVCYIGCGVTTGIGAVINTAKVEAGANVIVFGLGGIGLNVIQACRMVGADMIIGVDINNSKKAIASKFGMTHFVNPKEIEGDLVSYLVELTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGEEISTRPFQLVTGRVWKGTAFGGAKGRTDVPKIVEWYQSGKINIDDLITHVMPLEEINTAFDLMHKGESIRSVITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z527</accession>
    <name>K9Z527_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219574.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1744"/>
    <dbReference type="EnsemblBacteria" id="AFZ53847">
        <property type="protein sequence ID" value="AFZ53847"/>
        <property type="gene ID" value="Cyan10605_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1744"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1851"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152999_0_0_3"/>
    <dbReference type="OMA" id="TGVCPTE"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="14688" checksum="4E18FF4A39E72F5F" modified="2013-03-06" version="1">MKKRVTLSFPRTVVQMPVTYRLAKEFNIAANIIRAAVAPNQVGKLVLELSGDIDQLEAAIDWMKSNNIGVSLTTGEIVIDEEICVHCGLCTGVCPTESLTINPSSYQLQFRQQTCIVCEQCIPTCPVQAITSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z541</accession>
    <name>K9Z541_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219979.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2168"/>
    <dbReference type="EnsemblBacteria" id="AFZ54254">
        <property type="protein sequence ID" value="AFZ54254"/>
        <property type="gene ID" value="Cyan10605_2168"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2168"/>
    <dbReference type="eggNOG" id="ENOG502ZARE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203728_0_0_3"/>
    <dbReference type="OMA" id="AETQWDM"/>
    <dbReference type="OrthoDB" id="1151983at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="27602" checksum="429D167798352030" modified="2013-03-06" version="1">MTFFKPRQPILQRKQSSSDTQQFLSMKCLRIKSAEKFFLSGIYTCVDQAMLVWGVVAAIIFFSAQFLSVSWADQAFFWSVFTIFAIIVMTSLTYSWAVWEKVSGLLYGWIFLMIFGLIITDSAIAFSWGYILGHLCELWLILSALGYFLTGWMMRSRAFFLAGIIHGSMVLVLPLFAGWQFATTGLVMMSNLFLFSEGQWDMLLPRELKEYSVEEVNHVSLTRKSAHQDSSTRNQLSIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z592</accession>
    <name>K9Z592_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220075.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2266"/>
    <dbReference type="EnsemblBacteria" id="AFZ54351">
        <property type="protein sequence ID" value="AFZ54351"/>
        <property type="gene ID" value="Cyan10605_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2266"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2407"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_1_3"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="44322" checksum="0C95543F7ACCEC95" modified="2013-03-06" version="1">MLNVNEVEQIISDLIKPIKDIELVSLSSVDNRVLAQDITSDLDFPYWDNSAMDGYAVKYSDVALTSEKNPVILKVIEEIKTGYSPQKKLKMGEAARIFTGGMLPQGADTIVIQENTLRQGDNVLITHPPLKGEFVRHKGSFYQAGKCLIPAGSRINAPEVAILATAQCLDIPVVRSPRIAIISTGDELISPQDTLKTGKIIDSNQYLIASFLKQNGAIPLPWGIIPDELDALETEVKKALAEADWIISTGGVSVGEYDYVDKVIEKLGGEIKVKNVRMKPGKPLTIATFGENKLYFGIPGNPVSTMVTCWRFLKSAIAKLSGEINPSSLPIVKGITCNHLRSQGTRETYLWGYTNLVDGYYQFTMAEGSHNSGNLINLQGVNSLAIIPVGVNLIEMGDDVSIFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B1</accession>
    <name>K9Z5B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219467.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1633"/>
    <dbReference type="EnsemblBacteria" id="AFZ53740">
        <property type="protein sequence ID" value="AFZ53740"/>
        <property type="gene ID" value="Cyan10605_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1633"/>
    <dbReference type="eggNOG" id="ENOG503331U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179977_0_0_3"/>
    <dbReference type="OMA" id="PIIMATI"/>
    <dbReference type="OrthoDB" id="2041399at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="7771" checksum="2EF6ABE15A6512D4" modified="2013-03-06" version="1">MDKDSRFAFLVIGLPFIGLIYCLGIIVFFLVSPIAQNHPLITGIIAATVPFSIAAFIWIKASAKAYGKKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E4</accession>
    <name>K9Z5E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220130.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2322"/>
    <dbReference type="EnsemblBacteria" id="AFZ54406">
        <property type="protein sequence ID" value="AFZ54406"/>
        <property type="gene ID" value="Cyan10605_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2322"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2466"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266350_0_0_3"/>
    <dbReference type="OMA" id="CHLFTYD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="739"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="695"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1028"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1244" mass="141352" checksum="8143FCB8C2E9F64A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J8</accession>
    <name>K9Z5J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220143.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2335"/>
    <dbReference type="EnsemblBacteria" id="AFZ54419">
        <property type="protein sequence ID" value="AFZ54419"/>
        <property type="gene ID" value="Cyan10605_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2335"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2479"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035027_0_0_3"/>
    <dbReference type="OMA" id="FNKVDQY"/>
    <dbReference type="OrthoDB" id="591769at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="67"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="472" mass="52132" checksum="F63A415EFDC7022E" modified="2013-03-06" version="1">MWEEDWENAIIDFAHWQGEINYHKAQESLRNLLLNLDLKEEEKQGLETEIAHLNQMLQKLEDSVIQIAAFGMVGKGKSSVLNALIGQDIFITGPLHGVTREIDQTNWRLSKESIGNGEQNIQRLIKGSENVQIQLIDTPGIDEIDGETRETLAHDIASRVDLILFVIAGDITRVEYQALCQLREVGKPMILVFNKIDQYPQSDRIEIYSTIRDVRVRELLSPDEIVMVSASPLETVAVKDKEGKVKIIRQRGKPQIGDLQLKILEILHQEGKSLVALNTMLSTGQINERLIQQKLVYRDAEAEKIIQQTMMTKAGAIALNPVTAIDLFTGAIIDVVMILRLSQLYNIAMTQQSAVKLLQKIAISLGGITASDVLVTFGLSSLKGILGLTTPVSGGLTVVPYMSVAIAQGAFAGVSTYTIGQICKVYLANGASWGENGPHAVVENIINSLDETSILNRIKGELKAKLGRRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S8</accession>
    <name>K9Z5S8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220228.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2422"/>
    <dbReference type="EnsemblBacteria" id="AFZ54504">
        <property type="protein sequence ID" value="AFZ54504"/>
        <property type="gene ID" value="Cyan10605_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2422"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620686_0_0_3"/>
    <dbReference type="OMA" id="MEEINYL"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="441" mass="50701" checksum="B587D2ABABAD5A63" modified="2013-03-06" version="1">MKINYDLIIIGLNESAISAAEYALRFGARVAFIHNSNFGFLSKNIILDLNIDSLILIHNILAQEARKIDYKIENLKLIGLDTYTQESVFSFSQTNRKIQVSMGKYTLISPVAIMTDILNKNLIVDNNLNVNKVNIYKNFSDLKNILNSAIASIIIKGSNLEAIYLAQQLTSPNKSIILPIKNKQLLPTEDKDISWKLQLILEAKGIKICDANADKLETNQNISNENNFIINTEKNISYDDYQDLGNDLGLKWQGYNILANEKLQTHNSKIYACGEILGGYNLANLNEYEAKIAVDNSLFFPLKKVDYGNISYSLNTNPRIHRIGYTEKQALQLYHNNFYIIKLDVNLNYHHYSNFIKLIISNDNLILGFHGLGENLEELFIVIKNIKQNRYGINYLFRENFNNIYTYKIVNQIKEKFLEKEKKQNNIIMGIRETFLLCKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T0</accession>
    <name>K9Z5T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, sigma 70 subunit, RpoD subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220269.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2465"/>
    <dbReference type="EnsemblBacteria" id="AFZ54546">
        <property type="protein sequence ID" value="AFZ54546"/>
        <property type="gene ID" value="Cyan10605_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2465"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2610"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_3"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017848">
        <property type="entry name" value="RNA_pol_sigma_RpoD_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02997">
        <property type="entry name" value="Sig70-cyanoRpoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="332" mass="38489" checksum="4A4FA35197F63E4F" modified="2013-03-06" version="1">MSNAKVTANINDVDKRRVNTVDMVRTYLQEIGKVPLLSHEQEIVFGKQVQQMMSLYEVKENLEKNLEREVTLEEWAQKADKTPNEVKKIIHQGKRAKQKMIEANLRLVVAIAKKYQKRNMEFLDLIQEGSLGLERGVEKFDPTKGFKFSTYAYWWIRQAITRAIAQQARTIRLPIHITEKLNKIKKTQRELSQKLGRSPSPNEIAEALQLEPAQIREYFSIARQPISLDVKVGDNQDTELSELLEDEGVSPDNYITQELMRQDLQKLLGELTPQQQQVVRLRFGLEDGKELSLAKIGQRMNISRERVRQLEQQALAHLRKKRSSVKEYIVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U5</accession>
    <name>K9Z5U5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Photosystem II manganese-stabilizing polypeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PsbO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219672.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1843"/>
    <dbReference type="EnsemblBacteria" id="AFZ53945">
        <property type="protein sequence ID" value="AFZ53945"/>
        <property type="gene ID" value="Cyan10605_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1843"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1956"/>
    <dbReference type="eggNOG" id="ENOG502Z7ZP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063138_0_0_3"/>
    <dbReference type="OMA" id="GKANDCP"/>
    <dbReference type="OrthoDB" id="1569080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010242">
        <property type="term" value="F:oxygen evolving activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042549">
        <property type="term" value="P:photosystem II stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002628">
        <property type="entry name" value="PSII_MSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34058">
        <property type="entry name" value="PTHR34058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01716">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938628" description="Photosystem II manganese-stabilizing polypeptide" evidence="5">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30455" checksum="72B2FEA6DA743B61" modified="2013-03-06" version="1" precursor="true">MRFRSLFVAFLIVCLGFLNACSDNVAKAYDPNTITYDEILNTGLANKCPEISEFTRGSIAISPDEPLAIVDMCLEPQEYFVKEEPVNKRQEAKFVQGKLLTRDTTSLEQIRGTLTVDEEGVLTLTELDGIDFQIATVLLPGGEQVPFFFTIKKMVATTEPGFTAVNTSADFSGEFKVPSYRGASFLDPKGRGLSSGYDNAVALPAGADKEDYLRSNLKQYETRNGEISLQITKVDGETGEISGVFESEQPSSTDLGAEEPEEVKIRGVFYARLEPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z625</accession>
    <name>K9Z625_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220364.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2561"/>
    <dbReference type="EnsemblBacteria" id="AFZ54641">
        <property type="protein sequence ID" value="AFZ54641"/>
        <property type="gene ID" value="Cyan10605_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2561"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2718"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_3"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="423" mass="45777" checksum="4D81F8B1C97C79E9" modified="2013-03-06" version="1">MDSCVDLKLFSLPAKQGRWLLIPVGIIVLLCLGSVYSWSIFRKPLETQLNITATESLLPYTIGLLSYSILMPIAGFFITRIGTRVITAIGGLIVGAGYILASFAPNITLMTLSYGVIAGAGVGIAYGVPMAVVAKWFPDKKGLAVGLTIIGFGLSPLISAPLANQLIISYGVNSTLRILGITFIIIISTMAIALKLPPSHWNLSFSSTSVNNASVMVNYTPMLKTPSFYGLWFCYAIGALVGLSAIGISSPVGEEIIQIDSNFAARSVSLFALFNGISRPLFGWLTDRFSPRQVAIAQRHFVIASFTIIIIACTLMISAQAGDIATYLIAFCLFWFCLGGWLAMAPTMTLRFFNPDNYAQNYGIVFTAYGIGALIGTVFVGQMRDLFGSYTYGFYIMGFLGIIGIFIAQFTLKSPHSSKDYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z650</accession>
    <name>K9Z650_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219605.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1776"/>
    <dbReference type="EnsemblBacteria" id="AFZ53878">
        <property type="protein sequence ID" value="AFZ53878"/>
        <property type="gene ID" value="Cyan10605_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1776"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035485_0_0_3"/>
    <dbReference type="OMA" id="NWLVRTA"/>
    <dbReference type="OrthoDB" id="322022at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016837">
        <property type="entry name" value="Uncharacterised_Ycf55_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022552">
        <property type="entry name" value="UPF_Ycf55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12452">
        <property type="entry name" value="DUF3685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026434">
        <property type="entry name" value="RR_ycf55_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="570" mass="66372" checksum="7639C5CC76DF4BC4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z654</accession>
    <name>K9Z654_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220347.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2544"/>
    <dbReference type="EnsemblBacteria" id="AFZ54624">
        <property type="protein sequence ID" value="AFZ54624"/>
        <property type="gene ID" value="Cyan10605_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2544"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_3"/>
    <dbReference type="OMA" id="ADHTHLC"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="263"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="479" mass="53718" checksum="F3FED6F5C764B30A" modified="2013-03-06" version="1">MKLIRQLQKIIKKIKIPSSSLQFQLTLELVILSVIGLGSVAFWAGWQMEQNLVAAHKQTLEYIAMRFPEQLEVYNEAESLETVIEKAISRVETSNLMVWVKNPQGQLLGQSSSLNNSLVEFQAVENTQQIPTKPQVVRFNGRDIVLCGTPLIVNGDMVGKLYLSQDITLDQQKLNFSLWRLFFISIVTVTVLVIAISYTISTGLKPLKKMSRVASTIKADDLSGAKLTLNQAPQEIIGLAQAFNEMLFRLSASWEQQRQFVGNVSHELRTPLTIVLGYLQSLLRRSDNLSTHQIQALETATAETERTIRMLEDLLDLARADSGNLHFHCQPLMLNTLVTEVAQMSQKVTDRTINLIITDEDVITCADQDRLQQVLINLVDNALKYSSPPQPIDIILEKCFPNALIHIRDYGIGISLAHQQRIFERFYRADDGMTRSRDGTGLGLALAKGMIEGMEGTIKVRSKPQEGSVFTISLPLWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z655</accession>
    <name>K9Z655_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ordered locus">Cyan10605_1781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219610.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1781"/>
    <dbReference type="EnsemblBacteria" id="AFZ53883">
        <property type="protein sequence ID" value="AFZ53883"/>
        <property type="gene ID" value="Cyan10605_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1781"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1890"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_3"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="670" mass="73401" checksum="1DBF35C48969E3C9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z686</accession>
    <name>K9Z686_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2156"/>
    <dbReference type="EnsemblBacteria" id="AFZ54242">
        <property type="protein sequence ID" value="AFZ54242"/>
        <property type="gene ID" value="Cyan10605_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2156"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2291"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_6_0_3"/>
    <dbReference type="OMA" id="MFHFTGQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="14774" checksum="B1B087D1A9412FC1" modified="2013-03-06" version="1">MAILTTTRSKEVAISEQLNLTVSLRGTREVRNNCQIFHLIGQLDAFSEPTFQKIISGYISDKANKIVLDLSQIDFIDSSGLGALVRIAKQVENVKGKMQIVTNPRVTQTVKMVRLEKFLKLQNSLDEALKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C8</accession>
    <name>K9Z6C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220454.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2657"/>
    <dbReference type="EnsemblBacteria" id="AFZ54731">
        <property type="protein sequence ID" value="AFZ54731"/>
        <property type="gene ID" value="Cyan10605_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2657"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2822"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_2_3"/>
    <dbReference type="OMA" id="YNSIHPL"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="10961" checksum="F0C9906DFC5B4751" modified="2013-03-06" version="1">MNLELLKEKREEIIKIASKHGAYNVRVFGSVARGEADEKSDIDFLIDYDIDKITPWFPVGLIHDLQDFLGKKVDVVTASGLKERIKERVFQEAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E4</accession>
    <name>K9Z6E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219703.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1878"/>
    <dbReference type="EnsemblBacteria" id="AFZ53978">
        <property type="protein sequence ID" value="AFZ53978"/>
        <property type="gene ID" value="Cyan10605_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1878"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1993"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021521_0_1_3"/>
    <dbReference type="OMA" id="TPYIAYD"/>
    <dbReference type="OrthoDB" id="956274at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ShlB" evidence="1">
        <location>
            <begin position="192"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="547" mass="61538" checksum="803D73764410E4FD" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E9</accession>
    <name>K9Z6E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220047.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2236"/>
    <dbReference type="EnsemblBacteria" id="AFZ54322">
        <property type="protein sequence ID" value="AFZ54322"/>
        <property type="gene ID" value="Cyan10605_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2236"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_3"/>
    <dbReference type="OMA" id="QYVFQLS"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="140"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="31134" checksum="6F0620A9F5EB9EA7" modified="2013-03-06" version="1">MLDKILYADSGTGHTQEMLKILLDIPAFKNSEINILHVIPPQVSADALAEKWEEGGKILSEIVKNVNIDPSKVATILKQGDPKDTVCNTAQEINADLILMGSRGLKRLESFLENSVSQYVFQLSDRPMLLVKDDIYVRKIKKVMLALDKSESSSYALEMALYLLRDYREAELYLVRVNPDMNADLELSTAEMEQNPILAPALQQAKRMGISAKCIVKGGKPAQQICKLADDNNIDLLLLGSPDRRPSIAKNLVDLDRLLGTSLSDYVRVNANCPVLLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6F1</accession>
    <name>K9Z6F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219708.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1883"/>
    <dbReference type="EnsemblBacteria" id="AFZ53983">
        <property type="protein sequence ID" value="AFZ53983"/>
        <property type="gene ID" value="Cyan10605_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1883"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1998"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3308339_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="39" mass="4491" checksum="4AD161FBA6060CCC" modified="2013-03-06" version="1">MSYLLDTHTLLWWLTDNPTLSNEAVKIISNPESIIFISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H0</accession>
    <name>K9Z6H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219728.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1905"/>
    <dbReference type="EnsemblBacteria" id="AFZ54003">
        <property type="protein sequence ID" value="AFZ54003"/>
        <property type="gene ID" value="Cyan10605_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1905"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2022"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_2_0_3"/>
    <dbReference type="OMA" id="GNFVFFN"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="21406" checksum="0D4AF4A944618898" modified="2013-03-06" version="1">MAISLQKGQRVSLDKVAPGLNAAFIGLGWDVNTTDTGVDFDLDASVFLLNSNEKLISDQHFIFYNNLTSPDPEKSIKHMGDNLTGEGDGDDEVIIVDLRKVPTDVNRIVVTVTIYDADKRKQNFGQVRNAFVRLVNVETKEEVLRYDLEEDFSTETALIMAEIYRKDGEWRMNAVGAGYQGGLQALLNRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I2</accession>
    <name>K9Z6I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUA5/yciO/yrdC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219895.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2081"/>
    <dbReference type="EnsemblBacteria" id="AFZ54170">
        <property type="protein sequence ID" value="AFZ54170"/>
        <property type="gene ID" value="Cyan10605_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2081"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_3"/>
    <dbReference type="OMA" id="QYWPGAL"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="20939" checksum="1C7ACD319CB1E5D9" modified="2013-03-06" version="1">MPLVNLDTLIEKAIASQVVSFPTDTLPALAVKPSHSELIFELKQRSLEKPLILMTSSIEEIWQYVKGTPEELNIWQNLAQQHLPGALTMVLPASDKIPPTMNPLNPHSIGVRVPKDAIAQEILGKTGALATTSANLSGESALTDMYDIADKFPSVYALEVKNLKISGIASTVVKWTGSDWQILRQGQISIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K1</accession>
    <name>K9Z6K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ordered locus">Cyan10605_2293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220101.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2293"/>
    <dbReference type="EnsemblBacteria" id="AFZ54377">
        <property type="protein sequence ID" value="AFZ54377"/>
        <property type="gene ID" value="Cyan10605_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2293"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2435"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_2_3"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="23496" checksum="CFC6566DE4C103D2" modified="2013-03-06" version="1">MDHSSSSFIISPYPQSIKLDKTLKLGVMASGSGSNFEAIARSIDEGELNAKIELLIYNNPEATVKNRAQKYQIPSLLLNHRDFSNRKALDRAIVEEFKARDVEWVIMAGWMRIVTEELLKAFPQRVINIHPSLLPSFKGINAIEQALEAQVKITGCTVHLVDLEVDSGPILVQAAVPILPNDTPETLHQRIQIQEHRIITQGIAIASALQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q2</accession>
    <name>K9Z6Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2804"/>
    <dbReference type="EnsemblBacteria" id="AFZ54871">
        <property type="protein sequence ID" value="AFZ54871"/>
        <property type="gene ID" value="Cyan10605_2804"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2804"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2981"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045385_0_0_3"/>
    <dbReference type="OMA" id="CFYVLNV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="174"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="34204" checksum="9DF840B0250A1DFD" modified="2013-03-06" version="1">MNLVPKFVINIKSMENKYSHLTAIEREKLSFPARYLHRKKLLKSNILDFGCGFGKDVEILSKKGYKITGYDPHYFPQYPQGKFDTILCFYVLNIVFLENQEEVIMNISQLLKPKGKAYFAVRRDIKKEGFRKHYIHDKPTYQRLVKLPFKSIYLDESCEIYEYQHFNQIKHQSSPCIFCKPYPKLILLTESTLAYAILDGYPLTKGHSLIIPKHHEENYFNLSFSLQSHCWQMVNRVQEIIGAKYQPDGFNIGFNVNQAGGQKVKHTHIHLIPRYRGDNQGKKHGIRCVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T4</accession>
    <name>K9Z6T4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="11" type="ordered locus">Cyan10605_2782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220571.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2782"/>
    <dbReference type="EnsemblBacteria" id="AFZ54849">
        <property type="protein sequence ID" value="AFZ54849"/>
        <property type="gene ID" value="Cyan10605_2782"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2782"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2955"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_3"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="613"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="711" mass="80160" checksum="92C7DE2F85C8F1BF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6T7</accession>
    <name>K9Z6T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220628.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2839"/>
    <dbReference type="EnsemblBacteria" id="AFZ54906">
        <property type="protein sequence ID" value="AFZ54906"/>
        <property type="gene ID" value="Cyan10605_2839"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2839"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3017"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118146_0_0_3"/>
    <dbReference type="OMA" id="TMTYLID"/>
    <dbReference type="OrthoDB" id="1893980at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938635" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="15901" checksum="33982E94E887225A" modified="2013-03-06" version="1" precursor="true">MLKKFYSLALLSLSLTMPLVFNTLTEAKFAQVKAQNVAPRQPLTVRSDIQEANSETGVVTARGNVYINYPARNIQATSAQAQYFSKERRLVLTGNVYVLQDGNTMRAETMTYLIDEGRFIATPETQQQVESIYLVDEEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W4</accession>
    <name>K9Z6W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-strand binding protein/Primosomal replication protein n</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220025.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2214"/>
    <dbReference type="EnsemblBacteria" id="AFZ54300">
        <property type="protein sequence ID" value="AFZ54300"/>
        <property type="gene ID" value="Cyan10605_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2214"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2353"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109737_1_0_3"/>
    <dbReference type="OMA" id="WGNLAQE"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="15989" checksum="6E3CA646401388A0" modified="2013-03-06" version="1">MNSCVLMGKIVRSPQLRYTQDNQLAIAEMMVEFENISPNSPPNTLKVVAWGNLALDIEKNYIEGNEVVVTGRLKMDLVERQNYKEKVAELTLSHIYPLSGSNPPHNPDNVVSLNSYQSNEDVDDYSFDDGEIDGKNLDNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z1</accession>
    <name>K9Z6Z1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220680.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2899"/>
    <dbReference type="EnsemblBacteria" id="AFZ54961">
        <property type="protein sequence ID" value="AFZ54961"/>
        <property type="gene ID" value="Cyan10605_2899"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2899"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_1_3"/>
    <dbReference type="OMA" id="QYYSAIE"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="16269" checksum="643604E23FC49FEB" modified="2013-03-06" version="1">MKVLIDTNIILDLALIRKPFYQEADEIFTFIEQGKITAFISATTFTDIYYILRKQKGKYWTFEFLQRLSALCKINPITEEVIIKAINNSYKDFEDDIQYYSAIINNLNVIVTRNIKDFPKDNITILQPEELIFILTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z8</accession>
    <name>K9Z6Z8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220240.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2436"/>
    <dbReference type="EnsemblBacteria" id="AFZ54517">
        <property type="protein sequence ID" value="AFZ54517"/>
        <property type="gene ID" value="Cyan10605_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2436"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2580"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_3"/>
    <dbReference type="OMA" id="SDCEHPG"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="54"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="386" mass="43307" checksum="094D85BE03EEBAB4" modified="2013-03-06" version="1">MTSEINTHRQNFIGLQDKYYFNYGGQGILPQSALNKIIDTYKFIDKIGAFGIKINSWIQENIDNAKTAIASEVGAKPKTIVLTENVTSSCNIALWGIEWQEGDEILLTDAEHPGVIASIKEIARRFEVKMTVCPIIQTLNNGNPVEIIKNHLTAKTRLLVISHVLWNTGQVLPLKEIVQVCHNYPHQNKPIQVLVDGAQSAGGIPLNLVESEVDYYGCTGHKWLCGASGVGFLYIREDLLTSLHPTFIGWRGLDFTNSDLTFTDDGSRFEVATSAYPLYTGLQEAIATHQSWGTIEERYDRIKKLSAYLWSKLQQIEGIECLKKDTPPESGLVSFYPKPGQDPQKIVKMLEEKGFFLRTLANPYCIRACVHYLTLESEIDELIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z755</accession>
    <name>K9Z755_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4332 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220129.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2321"/>
    <dbReference type="EnsemblBacteria" id="AFZ54405">
        <property type="protein sequence ID" value="AFZ54405"/>
        <property type="gene ID" value="Cyan10605_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2321"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2465"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117602_0_0_3"/>
    <dbReference type="OMA" id="GTQYCGL"/>
    <dbReference type="OrthoDB" id="1642788at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025567">
        <property type="entry name" value="DUF4332"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14229">
        <property type="entry name" value="DUF4332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4332" evidence="3">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15571" checksum="8BE95FB5D4EF4A9C" modified="2013-03-06" version="1">MSIAISDLPGMQKTDIDRLQNLGITNIQQLLVMGKNKQDRELLAQKMGVSPRYVHKWFALADLARLPSVGVEYCGLILHSGIISVAQLSQCNAPQLQKQILRLQVANLRRRDLCPSFSLVQSWIQEAKQDKDSNRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z789</accession>
    <name>K9Z789_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220728.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2947"/>
    <dbReference type="EnsemblBacteria" id="AFZ55009">
        <property type="protein sequence ID" value="AFZ55009"/>
        <property type="gene ID" value="Cyan10605_2947"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2947"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3136"/>
    <dbReference type="eggNOG" id="ENOG5031S34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067692_2_0_3"/>
    <dbReference type="OMA" id="LGWWPIL"/>
    <dbReference type="OrthoDB" id="1664503at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021919">
        <property type="entry name" value="CCB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35302">
        <property type="entry name" value="PTHR35302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12046">
        <property type="entry name" value="CCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="173" mass="19806" checksum="52A7303F61AA08F4" modified="2013-03-06" version="1" precursor="true">MTSTLLLTILLMIGLFFFIRGSIKDRTEIVTLACQDNEDNILSYLRNYFLQRSYQVKAIDPDKNKVTLEGFVSPSIFLASFLSFLAGCGLFCFALVLSMLFKTEYIYFVGLVIFAPLAGWFYWRGASRVEEVAFRLDAKPENSKDTIITIQAHRDELIELQSSFPFSYTVQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z795</accession>
    <name>K9Z795_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ordered locus">Cyan10605_3011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220790.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3011"/>
    <dbReference type="EnsemblBacteria" id="AFZ55071">
        <property type="protein sequence ID" value="AFZ55071"/>
        <property type="gene ID" value="Cyan10605_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3011"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3208"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_0_1_3"/>
    <dbReference type="OMA" id="CDVKESW"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="34"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="24814" checksum="E8E52C66780C1A42" modified="2013-03-06" version="1">MLLFNKKEEDIKDYLKVEYPVVEIFHSLQGEGFWAGVNAFFIRLAGCDVYCPWCDQKETWSMKKHPLFTVENLLNEINTVETKHIIITGGEPLLHNLLPLTKILKYGGYQTHLETSGSNVFTGEFDWVTLSPKPYKKPHESIYAHVDELKVVIDNENDLKWAASEAEKLPKYTVKYLQPQWENPASQKLVIDYILSHSQWRMSLQTHKYLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A5</accession>
    <name>K9Z7A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220179.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2372"/>
    <dbReference type="EnsemblBacteria" id="AFZ54455">
        <property type="protein sequence ID" value="AFZ54455"/>
        <property type="gene ID" value="Cyan10605_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2372"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2519"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029327_0_0_3"/>
    <dbReference type="OMA" id="TAYQAHG"/>
    <dbReference type="OrthoDB" id="584229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021801">
        <property type="entry name" value="DUF3370"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11850">
        <property type="entry name" value="DUF3370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="49208" checksum="E1442C0FB35C4A6D" modified="2013-03-06" version="1">MLELISFFFNQPSPSILLAQNNTPAIVTEENNTIRPLTGELNQIPVFNSNSPELIVGEGILLSTFPPDNKNTPTAHLNYPLQGRFDIFAHHVAKAVDENDTRTLYLGIILQNPTNETVTINILQGASYLSQPDAPFIKLPSLVESSNTYAGPGSRVMGEILQEKRQDIFPAQITLKAGESKMLLNAPIPVQTLEPKINGRSTYMRLLSDGEVYVASLAMYRDEENNPPSLSQWQDLLNNGELSAPRDLAPTPPDATGKRIYGRVAGVSIGNQWKTDLVDSVNSTILTIPESGKAFSYGLSTLVGGTFGLNQVQTAPLTVRYPDTAYSAHGNYGVEYSLTLPLFNPSNESKTVNIALSTPLKQETPKINFFENPPNQVFFRGLVQVKYNDNQNVPRWRYFHLVQNRGQKGENLVTVTIPPQGQKLVSIDFLYPPDATPPQILTVETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A7</accession>
    <name>K9Z7A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219978.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2167"/>
    <dbReference type="EnsemblBacteria" id="AFZ54253">
        <property type="protein sequence ID" value="AFZ54253"/>
        <property type="gene ID" value="Cyan10605_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2167"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2302"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745398_0_0_3"/>
    <dbReference type="OMA" id="GLWRHDI"/>
    <dbReference type="OrthoDB" id="1284147at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="39453" checksum="58453CB99E352E65" modified="2013-03-06" version="1">MYLLECHNQCPDCFSADLKLIPVADKQGEYEFYFNAKVNEQQESILDGKVKFSLRLAKLLVTFNDLDILEIYDINKDYIKIRKNTSKNHQEWLIKPNLLKDNSSVKLAKLKAVGDESNLTAQIVIDKSNVVLTDIEGLWVHNITPNKHAILERKVAEFIEKVYLSPYVSRAIFSYQKSETTPNFHHKNNQEIEQKISSLKNVIQGIYQNPQEDFNTLAKKANLNPLIDFVGANLIGVNLSGLNLSSANFQDANLRGADLTDVDLSEANLQNTKLNGVDLSGAYLEGANLTNANLTNASLALSNLIGANLTNANLTNTNLQNTSLGQTIVKGAIFANNLGLNEEKKQELISKGAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H0</accession>
    <name>K9Z7H0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP fibrillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2444"/>
    <dbReference type="EnsemblBacteria" id="AFZ54525">
        <property type="protein sequence ID" value="AFZ54525"/>
        <property type="gene ID" value="Cyan10605_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2444"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2589"/>
    <dbReference type="eggNOG" id="ENOG502Z9K6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069245_1_1_3"/>
    <dbReference type="OMA" id="NWRLLYT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PTHR31906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAP_fibrillin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="208" mass="23537" checksum="D6F0FFB22B0DD45C" modified="2013-03-06" version="1">MINYKKELLQAIAGKNRGLLATEKDKVQILTAVERLEDHNPTADPLDKPDLLNGDWRLLYTTSKNILGLDNLPFVKLGEIYQCIRTEGSRIYNIAEIMGLPFLEGLISVAAKIDTVSSKRVNVRFQRSIIGLQKVLGYISPKDLINKIEMGKLFPAVDLNWGNFPWSDRNLLFSSDKNEGGWLEITYLDEDLRIGRGNQGNVFILEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q0</accession>
    <name>K9Z7Q0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="7">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">queG</name>
        <name evidence="9" type="ordered locus">Cyan10605_2535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220338.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2535"/>
    <dbReference type="EnsemblBacteria" id="AFZ54615">
        <property type="protein sequence ID" value="AFZ54615"/>
        <property type="gene ID" value="Cyan10605_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2535"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2690"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030790_0_0_3"/>
    <dbReference type="OMA" id="ICDTDLS"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="312" mass="36463" checksum="EC6DF701B4536957" modified="2013-03-06" version="1">MEKLSEQIKEKALEIGFHRVGIVDVNENRDKQQENQKRLQKWLDNGYHAQMEWMDNPRRKDITLCWQEVKSIICLALNYYTPHQHSDNPEIGKISRYGWGRDYHRIITKKLKTLARWLTEKDPSAKVRYYVDTGPIQDKFWAQQAGIGWIAKNANVITREYGSWVFLGEILTNLPLEADQPHTNHCGTCTRCLSACPTNAITEPFVVDANRCIAYHTIENRNPQLPDEIAKNLNGWVAGCDICQDVCPWNQRFAQETDITDFHPYPENLHPKLADLANMTEQEWDKRFQGSALRRIKPQMWQRNAKTQMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q4</accession>
    <name>K9Z7Q4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220343.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2540"/>
    <dbReference type="EnsemblBacteria" id="AFZ54620">
        <property type="protein sequence ID" value="AFZ54620"/>
        <property type="gene ID" value="Cyan10605_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2540"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825672_0_0_3"/>
    <dbReference type="OrthoDB" id="1434449at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="336" mass="37873" checksum="EB9034C0256FC72E" modified="2013-03-06" version="1">MKKVIITHPIASATIEKLNLKSIHEKYSLEDKKAYYQEINNQAILYVPDIGAKQIPDEENDPSIDRLGYLLTQFQPDILIVGSNAVPAWVLTSWRSAVGNERELMVIRRGVDTRAIAVFTAEKLNIKVGNLPGINSPYVAQHMLKYLELYKADKNKNKIAIIGVGNIGKVIVNESLKYNLNTHIFSPSLIDKNRQSFYLQERGINPAQVICEDSLVKVIHNATHVAIAIPWKDKDGKPQADLITAKEIETLTQPCKIVSASVPRIFSESALRLMNELSQQGKMFVRIDTAQRRAEEFKPLYPHLQFAHNEAFASPECQEALDLGMFALIEQHFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U7</accession>
    <name>K9Z7U7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ordered locus">Cyan10605_2735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220530.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2735"/>
    <dbReference type="EnsemblBacteria" id="AFZ54807">
        <property type="protein sequence ID" value="AFZ54807"/>
        <property type="gene ID" value="Cyan10605_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2735"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2901"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_3"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="470" mass="50594" checksum="CB6D656EBAD8AF22" modified="2013-03-06" version="1">MERQRAFIILIIILVATAIVTLVNLPLQLGLDLRGGSQLTIQLETTPQVPEITPEKLQGVQSVISNRVNGLGVSEAVVQTVGSDRILVQLPGVSDPEEAERVLGGTALLDFRVETDNQEIRAEYQIKQQELASLIFQAQSLQGEALEAQQSKIEAVEKQIEELSTQLYEKTELNGEKLQGANFQPAPQGNDWEVVLEFNNEGGRLFAELTKQIAGTGRTLGIFLDNELISSPTVSAEYASTGIMGGRATISGGGGFTLEQARELALQLEGGALPLPVKIVENRTVGATLGQDSIRRSIIAGLVGLVLVLVYMVIYYRLPGFLADIALIIYALLTLACFSLAGVTLTLPGIAGFVLSIGMAVDANVLIFERTREELRDGKTLYRSVESGFYRAFSSILDGNVTTLIACAALFWLGSGLVKGFALTLAIGVVVSMFTALTCSRTLLLITVLGFPAVRQRPELFCPNLKAVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z813</accession>
    <name>K9Z813_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem I assembly BtpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221002.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3238"/>
    <dbReference type="EnsemblBacteria" id="AFZ55284">
        <property type="protein sequence ID" value="AFZ55284"/>
        <property type="gene ID" value="Cyan10605_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3238"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3452"/>
    <dbReference type="eggNOG" id="COG0434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075239_1_0_3"/>
    <dbReference type="OMA" id="ENFFDAP"/>
    <dbReference type="OrthoDB" id="1616314at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="29992" checksum="0F033AF2C44DE4C8" modified="2013-03-06" version="1">MITEKIFGTKKPVIGVVHLLPLPTSARWGGNLKAVMERAEQEATALAAGGVDGIIIENFFDAPFTKDKVDPAVVSAMTLIVDRIMSLVMLPIGLNVLRNDAQSGMAIASCVGAQFIRVNVYTGVMATDQGVIEGKAHEIQRYRRELGQDIAIFADVLVKHARPLGTPNLTSAVTDTIHRGLADGIILSGWSTGLPPSLEDLELAKSASQDTPVFIGSGANWENIGQLMTFADGVIVASSLKRHGNIHETIDPSRVSQFVEAASTPMVIPQKKETTEKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z819</accession>
    <name>K9Z819_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220261.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2457"/>
    <dbReference type="EnsemblBacteria" id="AFZ54538">
        <property type="protein sequence ID" value="AFZ54538"/>
        <property type="gene ID" value="Cyan10605_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2457"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2602"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304390_0_0_3"/>
    <dbReference type="OMA" id="MEGYSAN"/>
    <dbReference type="OrthoDB" id="1440294at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27389" checksum="9D0FFF636F4479A8" modified="2013-03-06" version="1">MDLETLENNHQEWLIDEFVEVANRLLPLYLPDIKGNSKVKEEINTRLVRSYTSQRLMDEPIRQNRYAFYRYRHLLQLLLIKRLLSDGIGTTAINDLLTSKTNEELKSLLIGGISLNLTTAHPPLQSIHNSTNSALDFLADLKGKRSQSPSTIRGNVKQKSQSSPAPNQDTMSALDETYNHQNLLDKEESWTRLRILDGLELHIRDDFVYPNSLKERESLIELFRNILSKFFKRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z827</accession>
    <name>K9Z827_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220266.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2462"/>
    <dbReference type="EnsemblBacteria" id="AFZ54543">
        <property type="protein sequence ID" value="AFZ54543"/>
        <property type="gene ID" value="Cyan10605_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2462"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2607"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_10_1_3"/>
    <dbReference type="OMA" id="SIEYWPN"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="23290" checksum="55292D72D6CECC72" modified="2013-03-06" version="1">MQEDIFIRQKQFFFDIWAKFYDFTLTTVFYQAIHTRLLDYINLPSSPLILDLGCGTGKLLNRLAEKFSDLKGIGADLSPEMLTKARLANTHHPRLIFVRADAHDLPFANNQFDAVFNTISFLHYLQPEKVFQEVARVLKKGGYFYLADYLGNNQMKKIFFTPGGIRFYDQVQRQKLASQAGLITVDHQYILGGVVLTIFQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z883</accession>
    <name>K9Z883_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnD</name>
        <name evidence="9" type="ordered locus">Cyan10605_3364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221124.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3364"/>
    <dbReference type="EnsemblBacteria" id="AFZ55406">
        <property type="protein sequence ID" value="AFZ55406"/>
        <property type="gene ID" value="Cyan10605_3364"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3364"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3582"/>
    <dbReference type="eggNOG" id="COG1791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125400_0_0_3"/>
    <dbReference type="OMA" id="TTHWFDM"/>
    <dbReference type="OrthoDB" id="1964262at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in metal incorporation in vivo" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21476" checksum="861C0150D632548D" modified="2013-03-06" version="1">MTALKIFLDNQPSTPIFDSDSIPEVDRVSKITHKLEEVGVRFQQWQTIENLTSGVSQEEVLNAYQQEVKQLMDEEGYLTVDVVSLTSAHPQKAEFRQKFLDEHTHSEDEVRFFVDGKGLFSLHIDNQVFEVLCTRGDLISVPANTRHWFDMGENPHFTAIRFFNNPEGWVANFTGSDIAQHFSRLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z896</accession>
    <name>K9Z896_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220672.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2886"/>
    <dbReference type="EnsemblBacteria" id="AFZ54952">
        <property type="protein sequence ID" value="AFZ54952"/>
        <property type="gene ID" value="Cyan10605_2886"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2886"/>
    <dbReference type="HOGENOM" id="CLU_2421992_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10594" checksum="CCD68CB56DA77E2F" modified="2013-03-06" version="1">MIILQRNIAIHRQPLDSLELPFQHFLYHSNYLHGLIVKEGLWLKSISEPRKSGEFGHDMEIKAISPINNDDLIIGIEIFMKSWGLSYKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C3</accession>
    <name>K9Z8C3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220346.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2543"/>
    <dbReference type="EnsemblBacteria" id="AFZ54623">
        <property type="protein sequence ID" value="AFZ54623"/>
        <property type="gene ID" value="Cyan10605_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2543"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2698"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_3"/>
    <dbReference type="OMA" id="HATIYDR"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="26209" checksum="0B1ED50BC523D6AE" modified="2013-03-06" version="1">MTNSILVVEDDQRLSQFIVTELKLEGYEVATADDGMEALEKVREFPPDLIILDWMLPRISGLDVCLRLRKTGIKIPIILLTARDEIPDRVLGLNSGADDYLTKPFSIEELLARINARLRSSQVNDTSEILQFADLKLNLLTREVFRSKDSIELTAKEFDLLEYLLRHPRQVLSRNQIIENVWDFDFMGESNIIEVYIRALRLKLEVNQSPRLIHTVRGVGYVLKDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K3</accession>
    <name>K9Z8K3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220776.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2997"/>
    <dbReference type="EnsemblBacteria" id="AFZ55057">
        <property type="protein sequence ID" value="AFZ55057"/>
        <property type="gene ID" value="Cyan10605_2997"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2997"/>
    <dbReference type="eggNOG" id="ENOG502ZBTP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101804_0_0_3"/>
    <dbReference type="OMA" id="YPYLLRP"/>
    <dbReference type="OrthoDB" id="1332018at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="25539" checksum="26D32920991B8C05" modified="2013-03-06" version="1">MLIPLKQDAINDLIPAIATGKQYAYYWANFPTLLKNLFISLVGVLFFWLLGSFFGRAGDNISLIFRIVMGLYWLWSPIYWASVRNNRFRRYRYCGFWRGKVLDVYLTEEIVKEESAIDKLGRVIIVENRRRLFNMEIADKSGFRATITTPVKRIYKSINRGQAVEGLLLTNDPDFMNIAQITDVYIPRNKLWLGEYPYLRRDVFLDIRRELAAIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M6</accession>
    <name>K9Z8M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2623"/>
    <dbReference type="EnsemblBacteria" id="AFZ54698">
        <property type="protein sequence ID" value="AFZ54698"/>
        <property type="gene ID" value="Cyan10605_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2623"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2786"/>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111934_0_0_3"/>
    <dbReference type="OMA" id="FHVACAE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="17766" checksum="BCD4A4079664FD13" modified="2013-03-06" version="1">MIKIYLDVCCLNRPFDDWSYERNRLEGESVTSILQLFNSEQYKLVSSEVVEVELRKMKNLDKLKQIKNLLKKADHTIILNQEIDARSQELEKLGFGLYDSFHIASAEYAMVDVLLTTDDRLLKKALKYQDLLKVKLDNPVIWLMNNILLKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J7</accession>
    <name>K9Z9J7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit gamma</fullName>
            <shortName evidence="11">RNAP subunit gamma</shortName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcriptase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoC1</name>
        <name evidence="14" type="ordered locus">Cyan10605_2998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11 12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11 12">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 Zn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">In cyanobacteria the RNAP catalytic core is composed of 2 alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220777.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2998"/>
    <dbReference type="EnsemblBacteria" id="AFZ55058">
        <property type="protein sequence ID" value="AFZ55058"/>
        <property type="gene ID" value="Cyan10605_2998"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2998"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3194"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030022_2_0_3"/>
    <dbReference type="OMA" id="WGERTLP"/>
    <dbReference type="OrthoDB" id="105573at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01323">
        <property type="entry name" value="RNApol_bact_RpoC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012755">
        <property type="entry name" value="DNA-dir_RpoC1_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034678">
        <property type="entry name" value="RNApol_RpoC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02387">
        <property type="entry name" value="rpoC1_cyan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="13">
        <location>
            <begin position="243"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="630" mass="71634" checksum="1111556B270C6CF4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L2</accession>
    <name>K9Z9L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220983.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3218"/>
    <dbReference type="EnsemblBacteria" id="AFZ55265">
        <property type="protein sequence ID" value="AFZ55265"/>
        <property type="gene ID" value="Cyan10605_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3218"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3430"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_1_3"/>
    <dbReference type="OMA" id="GRSCHLD"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26137" checksum="3C66C4A925FF467C" modified="2013-03-06" version="1">MHQTFDAALEINLLHANQAGADHNRSHFDEWGITCFNLMSSPGAGKTALLEKTLHCLRYALNMVVIEGDMTTELDADRLRQYGVPVIAINTGRSCHLDSKMVSGGIHQLKAQYNPSDFDLLWVENVGNLVCPAEFEVGEHAKVALLSITEGEDKPLKYPVMFQEADCLLITKMDLAPHLDFDLDKLINNVRQMNPDVTIIPVSSKTEMGLDQWFTWVKNQVSLIHQHQQLISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R5</accession>
    <name>K9Z9R5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="4" type="synonym">rpl28</name>
        <name evidence="5" type="ordered locus">Cyan10605_3061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220837.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3061"/>
    <dbReference type="EnsemblBacteria" id="AFZ55118">
        <property type="protein sequence ID" value="AFZ55118"/>
        <property type="gene ID" value="Cyan10605_3061"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3061"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3263"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_3_0_3"/>
    <dbReference type="OMA" id="FEPNLHT"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9409" checksum="3F31889781B4CDD8" modified="2013-03-06" version="1">MARVCQLTGKRANNGFAVSHSHRRTKKLQHANLQDKKIWWAEGNCFVRLRLSTKALKTLDKKGINAMAREAGLDLRQFKCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9U3</accession>
    <name>K9Z9U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221073.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3310"/>
    <dbReference type="EnsemblBacteria" id="AFZ55355">
        <property type="protein sequence ID" value="AFZ55355"/>
        <property type="gene ID" value="Cyan10605_3310"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3310"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3524"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_1_3"/>
    <dbReference type="OMA" id="HPHHTDY"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="160" mass="18547" checksum="C11FF77D6024B9B2" modified="2013-03-06" version="1">MSQGKKPQLPPSTDIELDHSYRANTEKWFEYPIVVHPHHTDYGGIVWHGNYIAWMEEARVECLQSIGIDYAHLVELGYELPVVEVNIRYHRSLKMGDRAIVKTRVNDLEGVRIHWDYEITAWRGNITYVTGKVTLVGIDREKGKIMRQLPPVLKDALIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA21</accession>
    <name>K9ZA21_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221158.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3398"/>
    <dbReference type="EnsemblBacteria" id="AFZ55440">
        <property type="protein sequence ID" value="AFZ55440"/>
        <property type="gene ID" value="Cyan10605_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3398"/>
    <dbReference type="eggNOG" id="ENOG5032ZAD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167416_0_0_3"/>
    <dbReference type="OMA" id="KIAQLNH"/>
    <dbReference type="OrthoDB" id="2101207at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10243" checksum="4F02F725333AC35E" modified="2013-03-06" version="1">MSNKDNFGSGFIIGTIVGGLVGGVVGSLVASKSQQSKDSDNSNQKKTSYSSLEDEFAMENARLSLEEKINQLNHAIDEVKFGLMSKQEKEKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA63</accession>
    <name>K9ZA63_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ordered locus">Cyan10605_3445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221203.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3445"/>
    <dbReference type="EnsemblBacteria" id="AFZ55485">
        <property type="protein sequence ID" value="AFZ55485"/>
        <property type="gene ID" value="Cyan10605_3445"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3445"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3670"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_0_3_3"/>
    <dbReference type="OMA" id="HASGWLR"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="218" mass="24279" checksum="1C1E5F0DB6744E2C" modified="2013-03-06" version="1">MTKILQIDASARVTRSLSRGLTNAFYQNWSASRPNDIWIKRDVGLNPPSAISEEWIASAFTPLDKRTPEQVAILRESDELLEELEPADIIVIGTPMYNYGMPSSLKAWIDQVIRIGRTFSFDLARGEQPIEPILTDKILVILASCGEGGFGFGEANASQNHLDTAIITASKLMGVTEHYVIRVEYQEFGDARHQKSVEDAHGKIPKLVQQLIQKIGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA84</accession>
    <name>K9ZA84_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NAD(P)-dependent nickel-iron dehydrogenase flavin-containing subunit</fullName>
            <ecNumber evidence="13">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221223.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3469"/>
    <dbReference type="EnsemblBacteria" id="AFZ55505">
        <property type="protein sequence ID" value="AFZ55505"/>
        <property type="gene ID" value="Cyan10605_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3469"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3694"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_3"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="441"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="529" mass="57443" checksum="CA0C8F5BDAB999D9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA99</accession>
    <name>K9ZA99_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55520">
        <property type="protein sequence ID" value="AFZ55520"/>
        <property type="gene ID" value="Cyan10605_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3485"/>
    <dbReference type="HOGENOM" id="CLU_3134728_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="49" mass="5845" checksum="9FCC1C06600535A5" modified="2013-03-06" version="1">MQLRILSLITCFVWGRYCPVEIKTEIKIDPEDSDSSLILFIDEQEQNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAE2</accession>
    <name>K9ZAE2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221066.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3303"/>
    <dbReference type="EnsemblBacteria" id="AFZ55348">
        <property type="protein sequence ID" value="AFZ55348"/>
        <property type="gene ID" value="Cyan10605_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3303"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3517"/>
    <dbReference type="eggNOG" id="COG5474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092224_1_0_3"/>
    <dbReference type="OMA" id="IPEVRLW"/>
    <dbReference type="OrthoDB" id="1671310at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014946">
        <property type="entry name" value="CRR6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35724">
        <property type="entry name" value="PTHR35724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08847">
        <property type="entry name" value="Crr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="157" mass="18786" checksum="61C8A9C57BED45B1" modified="2013-03-06" version="1">MTTVIKINQTQIHQLDLSPVINVIEKFDKSSEILNLEQEITFQIDYAREETDPRELSEISEIRLWFIALDSLYPWLPFCLNWREGELARYVAMLVPHQFNRSEGIQYNQEALDIWIMQKTFVLHRWLKQQGIKTNSRLKAMTQIFGYDLDDYLFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAS3</accession>
    <name>K9ZAS3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystinosin/ERS1p repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221211.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3456"/>
    <dbReference type="EnsemblBacteria" id="AFZ55493">
        <property type="protein sequence ID" value="AFZ55493"/>
        <property type="gene ID" value="Cyan10605_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3456"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135915_1_1_3"/>
    <dbReference type="OMA" id="WIIYGYK"/>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9460" checksum="CCC52478370FB624" modified="2013-03-06" version="1" precursor="true">MEWITIIGLMAGSLTTISFLPQAIKTWRSKSAKDISLAMFLCFCLGVVLWIIYGLFIMDIPVLVTNIVTLILAGTILFFKLKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZA9</accession>
    <name>K9YZA9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">carB</name>
        <name evidence="17" type="ordered locus">Cyan10605_0080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217971.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0080"/>
    <dbReference type="EnsemblBacteria" id="AFZ52239">
        <property type="protein sequence ID" value="AFZ52239"/>
        <property type="gene ID" value="Cyan10605_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0080"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.81"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_3"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="686"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="945"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization domain" evidence="13">
        <location>
            <begin position="404"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="851"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ52239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118582" checksum="C09C30E618F31D68" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZF0</accession>
    <name>K9YZF0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="6 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Cyan10605_0169</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 14"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218058.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9YZF0"/>
    <dbReference type="STRING" id="755178.Cyan10605_0169"/>
    <dbReference type="EnsemblBacteria" id="AFZ52326">
        <property type="protein sequence ID" value="AFZ52326"/>
        <property type="gene ID" value="Cyan10605_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0169"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.177"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_3"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="7"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="17">
        <location>
            <begin position="375"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="16">
        <location>
            <begin position="520"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ52326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="605" mass="65438" checksum="798C17680E846BDA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZK3</accession>
    <name>K9YZK3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="4">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mtnC</name>
        <name evidence="5" type="ordered locus">Cyan10605_0188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218076.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0188"/>
    <dbReference type="EnsemblBacteria" id="AFZ52344">
        <property type="protein sequence ID" value="AFZ52344"/>
        <property type="gene ID" value="Cyan10605_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0188"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.198"/>
    <dbReference type="eggNOG" id="COG4229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_3"/>
    <dbReference type="OMA" id="QLKGHVY"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043715">
        <property type="term" value="F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043716">
        <property type="term" value="F:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27107" checksum="0404DADEADB029F1" modified="2013-03-06" version="1">MIKAILTDIEGTTSSISFVHDVLFPYAYEKMGDFLSQHWHDETVKNAVGEVAKIENLDSYTPSQITSILQDWIKCDRKLTPLKDLQGIIWETGYKNQDFCSHIYEDAYEKLKLWHSQNIPIYIYSSGSIHAQKLFFAHTQYGDLSYLFSGFFDTNIGNKKEPNSYEKISQSIGLNPNYIIFLSDVEAEVNSASQVQMKTVLVARDLQTFNQLNIEQQTSHQLVKSFAEINIENNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZZ0</accession>
    <name>K9YZZ0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0337"/>
    <dbReference type="EnsemblBacteria" id="AFZ52484">
        <property type="protein sequence ID" value="AFZ52484"/>
        <property type="gene ID" value="Cyan10605_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0337"/>
    <dbReference type="HOGENOM" id="CLU_3151895_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5654" checksum="3696CC0ECC855045" modified="2013-03-06" version="1">MNEGIRIKPEVNVNSKITFSDFLLCTVDDVFNVLWEKQNWLMMGNYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z010</accession>
    <name>K9Z010_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructosamine/Ketosamine-3-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0359"/>
    <dbReference type="EnsemblBacteria" id="AFZ52504">
        <property type="protein sequence ID" value="AFZ52504"/>
        <property type="gene ID" value="Cyan10605_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0359"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.378"/>
    <dbReference type="eggNOG" id="COG3001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_1_3"/>
    <dbReference type="OMA" id="GSFYSAY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="291" mass="33158" checksum="7B4860058A0D415D" modified="2013-03-06" version="1">MTSEMWSEIISKINQNIEQKFEMCDRRSIGGGCINQAYQLIGTQESYFIKLNSASSLDMFMAEALGLEEMYSTHTILVPKPICYGIAGNNSYIVLEYFELGRGSSQSWQLMGKKLAQLHRYQKETRFGWKINNTIGSTPQINDWGDNWSEFFAETRIGYQLKLANRKGANFSNIGEIVAQIKDILSHRNPHPSLLHGDLWSGNAAFTADGTPTIFDPAFYYGDREADIAMTELFGGFPSDFYQGYNQEYPLDSGYQQRKTIYNLYHILNHFNLFGGGYLSQAKSMINRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D9</accession>
    <name>K9Z0D9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218365.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0492"/>
    <dbReference type="EnsemblBacteria" id="AFZ52634">
        <property type="protein sequence ID" value="AFZ52634"/>
        <property type="gene ID" value="Cyan10605_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0492"/>
    <dbReference type="eggNOG" id="ENOG5033JXA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203775_3_0_3"/>
    <dbReference type="OMA" id="CWEMELA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="6908" checksum="2A18C4DE670F4AE7" modified="2013-03-06" version="1">MNNQEPKIPNPEKIAETLKKARRACWEMELAGLELDEAIALLEQENRNQRKQYLNKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0H7</accession>
    <name>K9Z0H7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217949.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0056"/>
    <dbReference type="EnsemblBacteria" id="AFZ52217">
        <property type="protein sequence ID" value="AFZ52217"/>
        <property type="gene ID" value="Cyan10605_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0056"/>
    <dbReference type="eggNOG" id="ENOG5033F5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130865_0_0_3"/>
    <dbReference type="OMA" id="KNWRQIA"/>
    <dbReference type="OrthoDB" id="2017986at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="12117" checksum="EE13BC6C61EB00D7" modified="2013-03-06" version="1">MSTIIENDLKELKDLINLKFQQMDSRFDHMEAKIDKLEANYISLDKTVTKIEAKIDTMKPVFDKIPELSEKIGEYKNWKQISIILLTGFLTSVFWAFRNTPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I7</accession>
    <name>K9Z0I7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ordered locus">Cyan10605_0071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217964.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0071"/>
    <dbReference type="EnsemblBacteria" id="AFZ52232">
        <property type="protein sequence ID" value="AFZ52232"/>
        <property type="gene ID" value="Cyan10605_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0071"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.73"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_3"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="638" mass="68956" checksum="B12E6A690C179A84" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M6</accession>
    <name>K9Z0M6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromophore lyase CpcS/CpeS</fullName>
            <ecNumber evidence="3">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpcS</name>
        <name evidence="4" type="ordered locus">Cyan10605_0119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CpcS/CpeS biliprotein lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218009.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0119"/>
    <dbReference type="EnsemblBacteria" id="AFZ52277">
        <property type="protein sequence ID" value="AFZ52277"/>
        <property type="gene ID" value="Cyan10605_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0119"/>
    <dbReference type="eggNOG" id="ENOG5032XG4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096258_0_0_3"/>
    <dbReference type="OMA" id="NSVDWGK"/>
    <dbReference type="OrthoDB" id="1672344at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017009">
        <property type="term" value="P:protein-phycocyanobilin linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01459">
        <property type="entry name" value="Chrphore_lyase_CpxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018536">
        <property type="entry name" value="CpcS/CpeS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09367">
        <property type="entry name" value="CpeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20902" checksum="FD8208765F7D11D4" modified="2013-03-06" version="1">MDINNFLDKFVGDWFSQRTTYHLPQNQVDNAKANVTLTLLTADDSKITQLANQYHFNLDLSLGAFGVAAPLVLASSWDNSPDWGKPKQTGESLMLIFRSENDLNKGNIVRITNSSEIVKGEYVLAEDESLILRIIKDDQYLEERINFASDNLRLRNTIFKHNNQVRQTCFYSEIKRVVKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z165</accession>
    <name>K9Z165_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0813"/>
    <dbReference type="EnsemblBacteria" id="AFZ52946">
        <property type="protein sequence ID" value="AFZ52946"/>
        <property type="gene ID" value="Cyan10605_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0813"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.856"/>
    <dbReference type="eggNOG" id="COG4785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081427_1_0_3"/>
    <dbReference type="OMA" id="DVEETVW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="24723" checksum="F917C555FCF95D53" modified="2013-03-06" version="1">MLDLTIIDANTLELDLSKCNKKLKIFPFDPRLYIKRGMIFFKLAQLNESLKDFNKAEELNPQLTPYLWQRGLTYYYLGKYAKAGRQFELDLSVNSQDIEETLWLYLAIAKLENPQNAQECLLPVKYDTRGFMRQIYQVFAGKSDISTLTNINTNSSLREVFFYFLYAGLYYFAHEDNFQANLYIQKAIEVKIDDYMWYLACVHLNVFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z187</accession>
    <name>K9Z187_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218228.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0351"/>
    <dbReference type="EnsemblBacteria" id="AFZ52497">
        <property type="protein sequence ID" value="AFZ52497"/>
        <property type="gene ID" value="Cyan10605_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0351"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.368"/>
    <dbReference type="eggNOG" id="ENOG5032Z94">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146087_0_0_3"/>
    <dbReference type="OMA" id="FWALMIL"/>
    <dbReference type="OrthoDB" id="1496523at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025461">
        <property type="entry name" value="ABA4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14108">
        <property type="entry name" value="DUF4281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17398" checksum="A9F7B5BD464BB455" modified="2013-03-06" version="1">MIELNQLFNLTNLFVLPFWTMMVFLPNWQWTQKIMKSYVIFLPLIFVYIYLFITGLNSESIEILSNPKLTDLAQVFSNPNITFAGWVHFLVLDLFLGRYIYWQGQTEKIWTIHSLILCLFAGPIGFLSHIITRFIQLSLIQKTEAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z188</accession>
    <name>K9Z188_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">Cyan10605_0796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218660.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0796"/>
    <dbReference type="EnsemblBacteria" id="AFZ52929">
        <property type="protein sequence ID" value="AFZ52929"/>
        <property type="gene ID" value="Cyan10605_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0796"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.838"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_3"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="509" mass="57751" checksum="9859413F90AAF142" modified="2013-03-06" version="1">MLTLQENPLRVGLKQAKTPEPLILVIFGASGDLTQRKLVPALYQLKKEGRLPAEMTIVGVARREWSHDYFRQQMRQGIEEFSDGIGKEELWEDFAQGLYYCAGNMDEGESYQKLKTFLGELDGKRGTRGNRVFYLAVSPKFFPAAIKQLGAAKMLTEPLKHRLVIEKPFGKDLSSAQVLNRIVQNVCKEEQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDNIQITVAETVGVEERAGYYETAGALRDMVQNHLLQLFCLTAMEAPSGISADSIRGEKVKVLQGTHLADIKNLEKSAIRGQYTGGWMKGKPIPGYREEKDVNPLSTTPTFVALKLMVDNWRWQGVPFYLRTGKRLPKKVSEIAIQFKNVPLTIFQSAAQQTNPNILALRIQPNEGISLRFEAKMLGAELRTRTVDMDFSYGSSFGMATADAYHRLLLDCMLGDQTLFTRADEVEEAWRVVTPALTAWDAPADPNSIPFYEAGTWQPAEAEFLLNRDGRRWRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D1</accession>
    <name>K9Z1D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rad3-related DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218268.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0393"/>
    <dbReference type="EnsemblBacteria" id="AFZ52537">
        <property type="protein sequence ID" value="AFZ52537"/>
        <property type="gene ID" value="Cyan10605_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0393"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.416"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567260_0_0_3"/>
    <dbReference type="OMA" id="FRLYLLP"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="405"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="498" mass="57873" checksum="65E4CB29F4FAA360" modified="2013-03-06" version="1">MLEAKVHSQLRDFSRLHSEQEWIHQLTMGRMIARGLRLQSSTIIQTGINHKHYYLSYLIPALLSPYSVVIIVEENSLLEFIFEECIFIQKYIDYHKKILNYYPKNKELEKPTLYIVDTKTWLERIFKDEAIDHLTTIIVKGENLIETTYEYLTLTISYSQLLSMIEDLDFSHQDLIRGKLANLLQLIYSHPPNPYDSYLLEKQEKNLIKDILIHSQSNNKLLIDFLSSLFSQEKYIHYFIINRSQGSFLLKATPLELKSIMEEKWLDQNLIIIADYLEPEKVPLDYGNHLGLKLKDFTCLKFSPNPQGKILKIYFPDNFPFPNNPSFATKVNQEILALISGIKINHCPIIVIIDDVPLQGQITASLAANFGSRVKLKTTDLALNSILVCDTDFWLNYQDALLSPQLVIMATLPLPSLENPIISAKVSYFKSQKKDWFRLYLLPIAIKNLQRISISLRQNQGVLALLDNRVNYRIYGRQILQALEPYGKINYLDLDWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E3</accession>
    <name>K9Z1E3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="4" type="synonym">rps10</name>
        <name evidence="6" type="ordered locus">Cyan10605_0408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218283.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0408"/>
    <dbReference type="EnsemblBacteria" id="AFZ52552">
        <property type="protein sequence ID" value="AFZ52552"/>
        <property type="gene ID" value="Cyan10605_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0408"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.431"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_3"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="12107" checksum="29780CC9266953C4" modified="2013-03-06" version="1">MATLQQQKIRIRLKAFDRRLLDTSCTKIVETATRTNAQPIGPIPLPTKRKIYCVLRSPHVDKDSREHFETRTHRRVIDIYQPSSKTIDALMKLDLPAGVDIEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F0</accession>
    <name>K9Z1F0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218767.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0906"/>
    <dbReference type="EnsemblBacteria" id="AFZ53036">
        <property type="protein sequence ID" value="AFZ53036"/>
        <property type="gene ID" value="Cyan10605_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0906"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.952"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_3"/>
    <dbReference type="OMA" id="TGLLKCC"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="22090" checksum="7D012B4880865003" modified="2013-03-06" version="1">MTELSNPIIEKSFAIIDNIIGNHDLSAREYNIVRRIIHTTADFDYLNLFYCSNNAIDTAILALQNKTPIVTDVSMVKEGIKNMVGKTYQNQVIVAVKQAKIPKSGHTLTETGLLKCCLDYPNAIYVIGNAPTALIALCKKIEQQKIQPSIVIGVPVGFVNVLESKEYLSRLGIPQIQIKGNKGGSTVAAAIINALLVMSYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F8</accession>
    <name>K9Z1F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218298.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0423"/>
    <dbReference type="EnsemblBacteria" id="AFZ52567">
        <property type="protein sequence ID" value="AFZ52567"/>
        <property type="gene ID" value="Cyan10605_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0423"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.446"/>
    <dbReference type="HOGENOM" id="CLU_1388236_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="23156" checksum="2FB9C1D7FFA4B999" modified="2013-03-06" version="1">MLKITQDIQDWNKQFEIVWQPFANKIIYIFSSEYPQKLKLIKSNEDLNNYIHDIVKFYLKMWQDEKEDQGIWLEILMREYPIIAQDFVDSLNQMEINIPSQPVFLWSIKEIGAIASAMLIGIIILLWGQNMSNFNIDLITLRQGIISVGFIYTVFSVVKKIREKRIEDETNNLIKKLTSQIEIYHEKLGAIIRTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H3</accession>
    <name>K9Z1H3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218162.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0281"/>
    <dbReference type="EnsemblBacteria" id="AFZ52430">
        <property type="protein sequence ID" value="AFZ52430"/>
        <property type="gene ID" value="Cyan10605_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0281"/>
    <dbReference type="HOGENOM" id="CLU_1822178_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="16672" checksum="33FAC263840285CD" modified="2013-03-06" version="1">MEGNHKYLHYQDLKEYYHCLKIIDDQINQLSSAKQDLYWCESKLQEAQELVKPFGFTNQSINNLPQVNFYSKRIEREKVQNILQSITKNGEEILKNEQFIIIFNERINSYVLSKPTLAEKLKQLTTEKLLLQIGIVIYICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I0</accession>
    <name>K9Z1I0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218797.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0936"/>
    <dbReference type="EnsemblBacteria" id="AFZ53066">
        <property type="protein sequence ID" value="AFZ53066"/>
        <property type="gene ID" value="Cyan10605_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0936"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.985"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_3_3"/>
    <dbReference type="OMA" id="AYMNTQD"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044256">
        <property type="entry name" value="HCF244-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47128">
        <property type="entry name" value="PTHR47128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="36729" checksum="3DB051CDB13C2E09" modified="2013-03-06" version="1">MKILVIGATGTLGRQIVRHAIDQDYSVRCLVRNRGKAGFLKEWGAELVKGDICEFKSIESALEGVDAVIDAATARATDSLTIRQVDWEGKVNLIQACAKANIKRYIFFSLLNAEKFEDVPLMNIKHCTELFLQESGLDYTIFKIGGFMQGLIGQYGIPILDNQPVWVSGENTPIAYMNTQDMAKFVIKALEIPETVKKTYPLVGSRAWTGDEIIQLCERLSGKTAKISRIPLGLLRFLRGFTRWFKWTRNASDRLAFAEVLASGIALDAPMDEVYETLKIDPQEITTLEAYLQEYFDRIMKKIREIDYEKSKMKKRKKNSFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R3</accession>
    <name>K9Z1R3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanylyltransferase, Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6">2.7.7.13</ecNumber>
            <ecNumber evidence="6">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="6"/>
    <dbReference type="EC" id="5.4.2.10" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218830.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0969"/>
    <dbReference type="EnsemblBacteria" id="AFZ53099">
        <property type="protein sequence ID" value="AFZ53099"/>
        <property type="gene ID" value="Cyan10605_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0969"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1023"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017652_1_0_3"/>
    <dbReference type="OMA" id="NRPIMEH"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="383"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="533"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="636"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="837" mass="92877" checksum="FC52741387A7E3F0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S5</accession>
    <name>K9Z1S5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ordered locus">Cyan10605_1030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218887.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1030"/>
    <dbReference type="EnsemblBacteria" id="AFZ53156">
        <property type="protein sequence ID" value="AFZ53156"/>
        <property type="gene ID" value="Cyan10605_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1030"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1091"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_3"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="400" mass="42369" checksum="0E3B16719BEC0535" modified="2013-03-06" version="1">MAKKSVANLTKSDLEGKRVLMRVDFNVPMDNGAITDDTRIKAALPTINDLISKGAKVILCSHMGRPKGQVKDSLRLTPVAVRLSELLGKNVVKCDDCIGDDVTNAVNGMANGDVVLLENLRFYNEEEANDPEFAKKLASNADLYVNDAFGTAHRAHASTEGVTHYLSPSVAGFLIEKELKFLQSAIESPKRPLVAIIGGSKVSSKIGVIETLLEKCDKLIIGGGMIFTFYKARGLSVGKSLVEEDKLDLAKALEAKAKERGVEFLLPTDVIVADNFAPDANAQTVDINSIPDGWMGLDIGPDSVKTFQTALADCQSVVWNGPMGVFEFEKFAKGTEAIAHSLAEITAKGATTIIGGGDSVAAVEKVGVAEKMSHISTGGGASLELLEGKVLPGIAALDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z4</accession>
    <name>K9Z1Z4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218468.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0598"/>
    <dbReference type="EnsemblBacteria" id="AFZ52737">
        <property type="protein sequence ID" value="AFZ52737"/>
        <property type="gene ID" value="Cyan10605_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0598"/>
    <dbReference type="eggNOG" id="ENOG50346C1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435884_0_0_3"/>
    <dbReference type="OrthoDB" id="2163300at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="10349" checksum="F178E9BE8AF5D7AE" modified="2013-03-06" version="1">MHNYKLNNLTPFKSKWKNTPTKLIRIPEILESKILAYAHSLDNNQNADNSLVTVKLKEIIVKIDNKEKGYKNNSASQLIKDLKELINGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z231</accession>
    <name>K9Z231_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="5">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.60" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1065"/>
    <dbReference type="EnsemblBacteria" id="AFZ53189">
        <property type="protein sequence ID" value="AFZ53189"/>
        <property type="gene ID" value="Cyan10605_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1065"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1127"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_3"/>
    <dbReference type="OMA" id="WSSEVNN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="169"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="32171" checksum="28D6FC3D49C63770" modified="2013-03-06" version="1" precursor="true">MNHQLAFLGLGVMGAPMAKNLANAPCQIKVWNRTKNRPHIQPLLQESSLTMVDTIAEAVESAEIIFTCLGDVPDVEEVLLSESGVINFAPPNSLVVDFSTIGSTAVKNIASQLEKKQIRFLDAPISGGDIGAQQGTLTIMVGGKEKDFRECLPYLEIMGKNITHCGDVGSGQGVKLCNQVLASLHMVALCEAMKLAQVQNIDPNLIVKVCSTGAAGSWALSNLGKKIIEEDFEPGFMIKHILKDLRLIQETLQDRHLPGVELANQLFQVSAELNEGEGYNQGAQGMINAYQNLENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z233</accession>
    <name>K9Z233_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin-like metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218185.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52453">
        <property type="protein sequence ID" value="AFZ52453"/>
        <property type="gene ID" value="Cyan10605_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0305"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_3_1_3"/>
    <dbReference type="OMA" id="AKHFKHE"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="17498" checksum="8CCF7F5489CE0FD6" modified="2013-03-06" version="1">MSLIFAQWNPEYYTGNKKVDEEHRQLFEIVNELHDAMKKGHGKDVLQQTLDKLIKYTIQHFTDEEMFMLSKRYPRYQEHKKIHQELTQKVKELRNKFIAGNVNINIELLHFLNQWLAHHIKGEDFKLFKYIREQEELKSKSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B6</accession>
    <name>K9Z2B6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218264.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z2B6"/>
    <dbReference type="STRING" id="755178.Cyan10605_0389"/>
    <dbReference type="MEROPS" id="S26.008"/>
    <dbReference type="EnsemblBacteria" id="AFZ52533">
        <property type="protein sequence ID" value="AFZ52533"/>
        <property type="gene ID" value="Cyan10605_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0389"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.412"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_1_3"/>
    <dbReference type="OMA" id="IEPRWIP"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21185" checksum="F711E53C35CC2D18" modified="2013-03-06" version="1">MTKSSETVKQNFSLRTIIKENFTTIAFGLILALLIRIFIAEPRFIPSESMYPTLAIGDRLVVDKVSYNFTKPQNQDIIVFSPPPQLQILGYQQDQAFIKRIIAQAGETVAVKEGKVFVNNQPLEEDYILSPPQYNLDAIKVPQGYVFVMGDNRNNSNDSHIWGFLPVENIIGKAIFTFWPPEHIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K7</accession>
    <name>K9Z2K7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine amidotransferase of anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219113.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1268"/>
    <dbReference type="EnsemblBacteria" id="AFZ53384">
        <property type="protein sequence ID" value="AFZ53384"/>
        <property type="gene ID" value="Cyan10605_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1268"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1339"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_2_3"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Anth_synt_I_N" evidence="3">
        <location>
            <begin position="249"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="489"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="759" mass="86776" checksum="4CE883AF12B53835" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L4</accession>
    <name>K9Z2L4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="10" type="ordered locus">Cyan10605_1326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219170.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1326"/>
    <dbReference type="EnsemblBacteria" id="AFZ53441">
        <property type="protein sequence ID" value="AFZ53441"/>
        <property type="gene ID" value="Cyan10605_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1326"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1400"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_3"/>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
    <sequence length="555" mass="58541" checksum="B17A24BC4672B419" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EnsemblBacteria" id="AFZ52972">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </evidence>
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            <dbReference type="EMBL" id="AFZ52972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="852" mass="98254" checksum="E7C04F9B34E7B7F3" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
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                <person name="Fewer D.P."/>
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                <person name="Sivonen K."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="AFZ53012.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Talla E."/>
                <person name="Calteau A."/>
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                <person name="Herdman M."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
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                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Talla E."/>
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                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
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    </reference>
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    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_082394_0_0_3"/>
    <dbReference type="OMA" id="IEQWWVV"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="104"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="247" mass="28802" checksum="B1B5D623230033B8" modified="2013-03-06" version="1">MSASVKIGDLVINSENIFHLLAEKQMIAPLAREIIIDRAIASIPCSEEEIKVAEQQFFWQMQMNPQDTEKLNTWLERNYLTREQLQQRILRPIRLEKYKEQTWGEQLESYYLKRKNQLDKVLYSLIRTKNPGEAQELYFRLCEGESDFTQLAKQYSQGTEAQTGGLVGPVELNVPHPDIAQKLLTAQPGQVLPPTRIGEWIVILRLEKYISAHLDQNLRRRLLDELFGQWINEQIRDTVKVDLELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T1</accession>
    <name>K9Z2T1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218616.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0752"/>
    <dbReference type="EnsemblBacteria" id="AFZ52885">
        <property type="protein sequence ID" value="AFZ52885"/>
        <property type="gene ID" value="Cyan10605_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0752"/>
    <dbReference type="eggNOG" id="ENOG50313YR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407554_0_0_3"/>
    <dbReference type="OMA" id="WLPPFNK"/>
    <dbReference type="OrthoDB" id="1518988at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="206" mass="24520" checksum="3A3F9BCD688E4006" modified="2013-03-06" version="1">MSYSSDNSSHSNSQQLSLFESTSIYEVNKKPLKADFVMSESFLSQWKKRILNYQESQRNNNINQVNFNEELSLNIDAKNSDLSIIESLDPFSLKTHTDQFYNLPEYALSESCLYFILDTHLNLLLYVGETKLSPYHRWMNHDCKSYIQSYIELHRKYKIPVLIRSAFCWGVPTSRKVRQFLEKQLIIKWRSPFNKESWQHWGQPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W6</accession>
    <name>K9Z2W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218656.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0792"/>
    <dbReference type="EnsemblBacteria" id="AFZ52925">
        <property type="protein sequence ID" value="AFZ52925"/>
        <property type="gene ID" value="Cyan10605_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0792"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="453"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="595"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="854" mass="97620" checksum="C5946E5DE278453E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z7</accession>
    <name>K9Z2Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxysome shell protein CcmK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbon dioxide-concentrating mechanism protein CcmK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccmK</name>
        <name evidence="7" type="ordered locus">Cyan10605_0828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Interacts with CcmN and CcmO in the carboxysome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The tight homohexamer forms a small pore which is positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial microcompartments protein family. CcmK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218691.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0828"/>
    <dbReference type="EnsemblBacteria" id="AFZ52960">
        <property type="protein sequence ID" value="AFZ52960"/>
        <property type="gene ID" value="Cyan10605_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0828"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.871"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_3"/>
    <dbReference type="OMA" id="VIARPHA"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00854">
        <property type="entry name" value="CcmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046380">
        <property type="entry name" value="CcmK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 5" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="11086" checksum="DD466702EE2B0AEE" modified="2013-03-06" version="1">MPIAVGMIETLGFPAVVEAADAMVKAARVTLVGYEKIGSGRVTVIIRGDVSEVQASIAAGIDSANRVSGGEVLSTHIIARPHENLEYVLPIRYTEEVEQFRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z310</accession>
    <name>K9Z310_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1485"/>
    <dbReference type="EnsemblBacteria" id="AFZ53596">
        <property type="protein sequence ID" value="AFZ53596"/>
        <property type="gene ID" value="Cyan10605_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1485"/>
    <dbReference type="HOGENOM" id="CLU_2860199_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="64" mass="7122" checksum="A4FAAB66215300DF" modified="2013-03-06" version="1">MLRKLGKIQDLLLLIFKISLPLSIVLYVLRGLGFLGFVSGGVLSFCILISIFSLLGFFLVKTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z333</accession>
    <name>K9Z333_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="14" type="ordered locus">Cyan10605_0864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218726.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0864"/>
    <dbReference type="EnsemblBacteria" id="AFZ52995">
        <property type="protein sequence ID" value="AFZ52995"/>
        <property type="gene ID" value="Cyan10605_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0864"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.907"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_3"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="312" mass="33449" checksum="59A86D3AC30C66E6" modified="2013-03-06" version="1">MKKVIVFGSINMDLAVTVPYLPSKGETLTGNNFNLSGGGKGANQAIALSRLGVNTELVGRVGNDEFGKQLKETLTDNEVNHDHVIIDDNHPTGVAIITVEASGDNQIIVVSGANGAVNEQDLANLESLLPSASYLLLQLEIPLWIITEAIALAKKYNVKVILDPAPALRLGEDIYKELEIITPNLIEASQLLGYEVDNSETAQKAGDWFLDRGVKTVIITMGEKGVYCATKEQKYWVSTPSVTVVDTVGAGDAFNAGLTTALIEGHPLPIAIQWGVINGSLSVTKSGSQSAFAHRHEFDQALGQYELNLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z374</accession>
    <name>K9Z374_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219383.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1547"/>
    <dbReference type="EnsemblBacteria" id="AFZ53656">
        <property type="protein sequence ID" value="AFZ53656"/>
        <property type="gene ID" value="Cyan10605_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1547"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1642"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_4_2_3"/>
    <dbReference type="OMA" id="IGHTITF"/>
    <dbReference type="OrthoDB" id="900869at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="249" mass="28399" checksum="05782BFFB5FC4BB3" modified="2013-03-06" version="1">MSNKRLVIGDVHGHYEALCSLFNHIAPLSEDQVYFLGDLIDRGPESSQVVEFVMKNDYHCILGNHEIMLLDALGNGKLNHQAFQSWLQNGGNATVMSYGHKMPSAEHIDWMKSLPFFFDLGDYWLVHAGVDPRLNITQQSPDQFCWIRSEFHSSEKPYFQDKTIIIGHTITFTFNGLKPGQIAKGEGWLGIDTGVYHHEQGWLSALDLNTNTVYQVDSFGKNFRSLPLSEVTHNVNTRKLFARRQKVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z387</accession>
    <name>K9Z387_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218903.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1046"/>
    <dbReference type="EnsemblBacteria" id="AFZ53172">
        <property type="protein sequence ID" value="AFZ53172"/>
        <property type="gene ID" value="Cyan10605_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1046"/>
    <dbReference type="eggNOG" id="ENOG502ZA3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244151_0_0_3"/>
    <dbReference type="OMA" id="LRSYCKT"/>
    <dbReference type="OrthoDB" id="1064435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="24125" checksum="DCC9DC9BD00CFFF3" modified="2013-03-06" version="1">MSRSKTIANFLSPKKEPKYYAQRSDLFSIDYLEQLEKSILSSPYLAKNQLSENFEQTRGFSVVFKSSSIDKVETEFPFFKTYLNTALKRPCNAFYLNALILDNGSRVDPHIDCSISSYEMVMLVPQLVSVLYVKIPDDLRGGELILESENKQVAKIKPQRNNLIYFIGNLLHSVNSVTSSQPRISLICEQYNLPPERLTKIPDLDIKSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z395</accession>
    <name>K9Z395_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide peptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218574.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0707"/>
    <dbReference type="EnsemblBacteria" id="AFZ52843">
        <property type="protein sequence ID" value="AFZ52843"/>
        <property type="gene ID" value="Cyan10605_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0707"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.740"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_0_3"/>
    <dbReference type="OMA" id="DSQEIHA"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="70"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="273" mass="29984" checksum="2D1D218511B1CB72" modified="2013-03-06" version="1">MIWPFKPSTRKQIARIEINGAIASATRERVLEALEEVEERKYPALLLRIDSPGGTVGDSQEIYSALKRLGEKIKIVASFGNISASGGVYIGVGANHIMANPGTITGSVGVIIRGNNLEKLLDKVGVSFKVIKSGPYKDILSFDRDLTTDEEEILQELIDSSYQQFVETVAEGRKLSVETVKSFADGRIFSGEQALKLGLVDRLGSEEDARRWACELVGLDPEKTECHTIEEPKSLLDRVFSGRGQVKSGVGSAINWLEFELATSGQPLWLYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F0</accession>
    <name>K9Z3F0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218851.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0991"/>
    <dbReference type="EnsemblBacteria" id="AFZ53120">
        <property type="protein sequence ID" value="AFZ53120"/>
        <property type="gene ID" value="Cyan10605_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0991"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1048"/>
    <dbReference type="eggNOG" id="COG1218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_3"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="Bisphos_HAL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="319" mass="35299" checksum="564B728C0E8FB009" modified="2013-03-06" version="1">MYQKEKEIAISAVLQASELCQKVRQDIPPALEKQDKSPVTVADFGSQAIICKALKDIFPDTPIVGEEDATELRQPEQKNTLTKITEYVKQIIDNASENQVLDWIDYGNGKVSRRFWTLDPIDGTKGFLRQDQYAIALALIEDGEVKLGVLGCPALNINQTQEQGCIFVAVRGEGSYRMPLNGGEMTKLQVVSNDDVQRFRFVESVEASHGDQERQNAIAQAVGITSQSVRVDSQAKYGIVASGEAALYLRLPSPKYPDYRENIWDHAAGAIVVEEAGGKVTDMYGNPLDFFTATKMMENRGVVVSNSKIHEKVLEALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H1</accession>
    <name>K9Z3H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression/formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219468.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1634"/>
    <dbReference type="EnsemblBacteria" id="AFZ53741">
        <property type="protein sequence ID" value="AFZ53741"/>
        <property type="gene ID" value="Cyan10605_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1634"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1735"/>
    <dbReference type="eggNOG" id="COG0409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_3"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="40562" checksum="20702EED8C164DF2" modified="2013-03-06" version="1">MKFVDEYRDSTVVKQYAQRIREITTKSWQIMEICGGQTHSILKYGLDQLLPSEISLIHGPGCPVCVTDIEKIDKAGAIASLPNVILCSFGDMLRVPGSKEDLLSIKAKGADIRIVYSPLDCIKIAEENPHKEIIFFAVGFETTAPTTAMTVYQADKKQLNNFSLLVSHVLVPPAMEAILSSTQCQVQGFLAAGHVCTVMGYHQYETISQKYQIPIIVTGFEPADILQGIYLCVQQLEKKENKVENQYSRCVKKEGNKEAQKLINQIFEITNYQWRGIGNIDNSGFKLREKYVMFDAETKFNHVSTTTSNADNNCISGQILQGIKKPHQCQAFGNKCTPENPLGAPMVSSEGACAAYYRYHLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H7</accession>
    <name>K9Z3H7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218664.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0800"/>
    <dbReference type="EnsemblBacteria" id="AFZ52933">
        <property type="protein sequence ID" value="AFZ52933"/>
        <property type="gene ID" value="Cyan10605_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0800"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.842"/>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_3"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="64"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="176"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="38139" checksum="CB96B608458A034F" modified="2013-03-06" version="1">MSNQTNFSLNCPLPITKYPHILMAHGGGGKLMKQLIDNMLLPVFSNGNFVEHDSAILNLTSNKIAFTTDSYVVNPLFFPGGNIGSMAVYGTVNDLAMAGAKPLYLSLSFILEEGLSFATFWEVIKSIKQASEISQVKIVTGDTKVVEKGKGDGIFINTSGVGIIEHNLTINPQQIQEEDVIILSGDIGRHGIAIMALREELEFETTIESDCAPLNHLVLQLINSGINIHCLRDITRGGLASILNEIAIDSDSEMIIQEKFIPVQEEVKGACEILGFDPLYIANEGRFIAFIPKNEAEKALSIFKQENPLATIIGKVEKKEKGRVILENKLGSKRIIEMLTGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M6</accession>
    <name>K9Z3M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218719.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0856"/>
    <dbReference type="EnsemblBacteria" id="AFZ52988">
        <property type="protein sequence ID" value="AFZ52988"/>
        <property type="gene ID" value="Cyan10605_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0856"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_3"/>
    <dbReference type="OMA" id="LPHEMRT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="41899" checksum="52BAE639EF6B093E" modified="2013-03-06" version="1">MEKILVIEDEINIARNIKQILDLSNFYTITADNGSEGVELAKEEMPDLILCDVMMPNLDGYQVLTELKKDGKTDNIPFIFLTAKSDRPYFRKGMELGADDYLTKPFTPDELFTAVNTCLAKHQKMKKQAQDKIDELSSRIQKALPHELYTPLNGMMVSASLLNEYAESMSVEEIKDMAKTLLDSSQRLHQISEKFVLYTYLEFLTNNSEKLEETRQKQYSCFTKTIIENIAKIEAEAFNRKSDLALEIEEASIKTSESDLHRIVKELVNNSFKFSHQGQHVKILSKISDDDSYHLFIINEGKCMTSEQLEEIGSFRQFHQEFFSQEGCGLGLAIVKKLINIYQGSIRIESLINNQTVVHVILPLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M9</accession>
    <name>K9Z3M9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219081.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1233"/>
    <dbReference type="EnsemblBacteria" id="AFZ53352">
        <property type="protein sequence ID" value="AFZ53352"/>
        <property type="gene ID" value="Cyan10605_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1233"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1301"/>
    <dbReference type="eggNOG" id="COG1625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037396_0_0_3"/>
    <dbReference type="OMA" id="CFIDQQP"/>
    <dbReference type="OrthoDB" id="504159at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017673">
        <property type="entry name" value="CHP03279_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03279">
        <property type="entry name" value="cyano_FeS_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Radical_SAM_2" evidence="3">
        <location>
            <begin position="67"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="224"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="438" mass="50462" checksum="125C567793E17B93" modified="2013-03-06" version="1">MKSASISHIIPDSIASEIGFEIGDKIVSINGIKPRDLIDYQFLCADEYLEIEVVDKWGKNHLIEIEKDYDEDLGLEFETALFDGLIQCNNKCPFCFIDQQPPGKRETLYLKDDDYRLSFLYGSYLTLTNLTAKEWSRIEQMRLSPLYVSVHATEPEIRSHLLKNQRAGEIKKQLAWFEEKRLQIHAQVVVCPNINDGEHLTTTLQDLFSFHNGDIPAVISTAVVPVGLTKFRPDKDELIPVSREKAREVIKQVQQLQEKFREKSGSTFAWLADEWFLIAQEELPPESHYEDYPQIGNGVGSIRQFIKEFGMIAEAKLPSKIEQKKEFIWIVGNAVETAFQPLVKRLNQVENLTVELRAFNSIYWGQEITVTGLLTGQDLLYHLEKENINKQILLPSLMLKHDEKKFLDDMTIEELEQKLTTKIYTVKDINQLIDIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R1</accession>
    <name>K9Z3R1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="7" type="synonym">rpl9</name>
        <name evidence="10" type="ordered locus">Cyan10605_0893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218754.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0893"/>
    <dbReference type="EnsemblBacteria" id="AFZ53023">
        <property type="protein sequence ID" value="AFZ53023"/>
        <property type="gene ID" value="Cyan10605_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0893"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.938"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_5_1_3"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="16905" checksum="DB2FDE293884436F" modified="2013-03-06" version="1">MAQKVQLLLNKNVEKLGKRGDVVDVAPGYARNYLVPQGFAVVVTPGILRQVEQRKEKERQRLQAILEEAKSRKTALQTINNFVIRKQVGEQDAIFGTVTTQDVVDVIKQSAGLDIERQDITVPEIKKTGKYSVSIKLHAEVTAEITVEVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T3</accession>
    <name>K9Z3T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218774.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0913"/>
    <dbReference type="EnsemblBacteria" id="AFZ53043">
        <property type="protein sequence ID" value="AFZ53043"/>
        <property type="gene ID" value="Cyan10605_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0913"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.960"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806120_0_0_3"/>
    <dbReference type="OMA" id="IDAHHFN"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="347" mass="39795" checksum="2A09C454050DC22E" modified="2013-03-06" version="1">MIQQTKNKRVFNHPERFIEGWYWLLPSKDLPKNKVKAVSLLGRDLAVYRTYTGNVVAMDAYCPHMGAHLAEGKVEGESLRCFFHNWKFSADGSCVEIPCLVKTLPLKVNTWPVQEAYGLIWLWTGNEVKLPIPFAPELEKEEVSTCISKIFVKECHPNVVMINAIDAHHFNTVHNFPVEIKFKSEIINPSVITFSNTTKGGKDSWLINLIQPFYKEQGTYSMCYWYGTVGTVTLGPDFLHFYIMFALRMLENGKTEGAMVSMTKRRSGFFGAVFNKLILWVTILVGEYFAKGDTQIFKTIKFNLKTPVWADHSIMEFIDHVEHQTVLQWGSWEQITEGIDSHLTNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W0</accession>
    <name>K9Z3W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd plastoquinol oxidase subunit 1 apoprotein</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_1133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218984.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1133"/>
    <dbReference type="EnsemblBacteria" id="AFZ53255">
        <property type="protein sequence ID" value="AFZ53255"/>
        <property type="gene ID" value="Cyan10605_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1133"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1200"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_1_3"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="53533" checksum="475E398C32ECC914" modified="2013-03-06" version="1">MDFLSDTLILSRMQFAFTAIFHMLWPVLTTGMAIYLVIVEGLWLKTKNPDYYHHARFWSKLYVLNFGIGVASGSPMAFQFGTNWAPFSESVGDFFGSVLGFEATMAFMLEAGFLGIMLFGWQRVNPTIHYIATICVAVGANLSTFWILTANSWLQTPAGGDFVDGKFIVKDYFAAIANPFMLKSVSHMFLATLETSLFVIGGISAWYILKKRHQAFFAKSFKIVLAVAIAITPLQIFVGHLSAEQVYHHQPTKLAAMEAQWETIPAGEKADWSLLAFPDEKTENNKWEITIPNAFPYILEFKSRLSEPVLGLKEWTPENRPRMVGLIYYSFRLMSGIAFVLVGVMLVSAIQWLRGKLSEENIIQQKWLMISWMWCAPLGYLAVESGWIVRCVGRQPWTVYGEIRTADAVSNLPAGDVLTSLTIFICLYTVLFFSALYFGSRIIAKGPKFDLPLPGDDKDLPVEVDSAQHIPDSRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X0</accession>
    <name>K9Z3X0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_1726</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219556.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1726"/>
    <dbReference type="EnsemblBacteria" id="AFZ53829">
        <property type="protein sequence ID" value="AFZ53829"/>
        <property type="gene ID" value="Cyan10605_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1726"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1833"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_3"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="50605" checksum="298175880A1015C3" modified="2013-03-06" version="1">MSKSFNYDLIIIGAGVGGHGAALHAVKCGLKTAIVEAGDMGGTCVNRGCIPSKALLAASGKVRELRETEHLQSMGVTVGGVSFDRGAIASHANDLVSKIQSDLTNSLSRLKVDIIRGWGKVAESQKVIVIGDDGSEKVITAKDIMLCPGSVPFVPRGVEVDGKTVYTSDQAVKLESLPQWIAIIGSGYIGLEFADVYTALGSEITMIEAMDQLMPTFDPDIAKIAERVLINSRDIETYTGVFATKITPGNPVKIELTDAKTKEIVDVLEVDACLVATGRIPATKNLGLENLGIETERGFIPVNDKMQVLKDGKVVPHLWAVGDANGKMMLAHAASGQGIIAVENMCGRDKTIDYRSIPAAAFTHPEISYVGLNEPQAKELGKNYGFEVATARTYFKGNSKALAEKETDGIAKIIFRKDTGELLGVHIIGIHASDLIQEAANAIASRQTVHELAFNVHAHPTLSEVLDEAYKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X6</accession>
    <name>K9Z3X6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ordered locus">Cyan10605_1332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219176.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1332"/>
    <dbReference type="EnsemblBacteria" id="AFZ53447">
        <property type="protein sequence ID" value="AFZ53447"/>
        <property type="gene ID" value="Cyan10605_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1332"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1406"/>
    <dbReference type="eggNOG" id="COG0447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_7_3"/>
    <dbReference type="OMA" id="IFKQTDA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="UniPathway" id="UPA00995"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrogencarbonate binding" evidence="3">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30530" checksum="7D6C2F2F2921A7C2" modified="2013-03-06" version="1">MNVHWQSVKEYEDILYFKWDGIAKIVINRPHKRNAFRPQTVFELYDAFCDAREDKKIGVILLTGAGPHTDGKYAFCAGGDQSVRGKGGYVDDAGVPRLNVLDLQKLIRSIPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGASYLARIVGQKKAREIWFLCRQYNAQQALDMGLVNTVVSVEELETEGINWAMEILEKSPIAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDYPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A2</accession>
    <name>K9Z4A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219746.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1925"/>
    <dbReference type="EnsemblBacteria" id="AFZ54021">
        <property type="protein sequence ID" value="AFZ54021"/>
        <property type="gene ID" value="Cyan10605_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1925"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2046"/>
    <dbReference type="eggNOG" id="ENOG502Z806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042901_0_0_3"/>
    <dbReference type="OMA" id="FYYADWG"/>
    <dbReference type="OrthoDB" id="533403at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="370" mass="43617" checksum="8647426AB2451732" modified="2013-03-06" version="1">MSEYQYYEFQTLDQPLTKQQQQKISQLSSRVRLNSRKAIFTYSYGDFPANEDQILADYFDALFYIANWGTVKLMFRFPISLVNINELKKYTYDDFITIDKIGSYLILKIEINDEERSDWIEEDNSYLDDLIELRQQILAQDYRVLYLAWLKAIELSKLYDDAPLKDIPEPPIPHGLNQLSESLKIFVELFEVNQNLIKVGATNSSKITPIPDNIFLENISKLSNIEKDDFLSRLLQEEPNLSLKLKQKLLELSELTNNKTTIEKRTIKQLFTEAEKIAQSEEKRQKEEARQKKIKELKAFANQENQAWLNVDNLIQKSNPKAYDEAKMILIKLKELAIYQGKEVEFYHKLEDIKQKYSRRPTFIARLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C0</accession>
    <name>K9Z4C0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219164.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1320"/>
    <dbReference type="EnsemblBacteria" id="AFZ53435">
        <property type="protein sequence ID" value="AFZ53435"/>
        <property type="gene ID" value="Cyan10605_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1320"/>
    <dbReference type="eggNOG" id="COG5579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124534_0_0_3"/>
    <dbReference type="OMA" id="WFVFPQI"/>
    <dbReference type="OrthoDB" id="1625285at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008546">
        <property type="entry name" value="UCP008546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="SSF140736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17460" checksum="0EC652DB971B43E1" modified="2013-03-06" version="1">MTNNNSYQDLYNLQRFVDAQEKVYKTVIDELKNAKKSSHWMWFIFPQINGLGKTSTSIFYSIKSIQEAKQYINHDLLGKRLKECVTILLTIEETSSEKIFGFPDCMKLKSSLTLFSEISDSDSIFYQGLNKFFRGSKDEKTLQILSTLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L4</accession>
    <name>K9Z4L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219062.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1214"/>
    <dbReference type="EnsemblBacteria" id="AFZ53333">
        <property type="protein sequence ID" value="AFZ53333"/>
        <property type="gene ID" value="Cyan10605_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1214"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_5_0_3"/>
    <dbReference type="OMA" id="RAREVEY"/>
    <dbReference type="OrthoDB" id="1981258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031975">
        <property type="entry name" value="Pilin_GH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16734">
        <property type="entry name" value="Pilin_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="176" mass="19528" checksum="ED60494917E9BE57" modified="2013-03-06" version="1">MWQLFYKMFLRYHKNNNDGFTLIELLVVIIIIGILAATGLPNLLAQVGKAREAEMKNALGTVARSQMAYHWEQQVFCCDGRTPDQILEALGVPINSKYISSWTFDTSTVASQVTFNITNNNWDKDGTRGLSAGVFFDPALVDAYSSIICQSFDPSATTAYPVITDPVCGTNAYQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q5</accession>
    <name>K9Z4Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane transport energization protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219294.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1454"/>
    <dbReference type="EnsemblBacteria" id="AFZ53565">
        <property type="protein sequence ID" value="AFZ53565"/>
        <property type="gene ID" value="Cyan10605_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1454"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1542"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_3_0_3"/>
    <dbReference type="OMA" id="LEKNVSW"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="69"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="23804" checksum="6A449ACEB7668A5A" modified="2013-03-06" version="1">MTLAELIDKGGVAIWPLLFLSILALGTIIERIWFWSKVLIKEELILNSIMDAAMTNWGKAGEIASRYRNHPLGKFLNTPLQLDNPDPDVFHLALETGADDELALMRKGDKILEGVIALAPLLGLLGTVLGLIRSLGSISVSDLGTASTTGVTLGIGESLISTAMGLIVAIISVVFYRLFQAFWFNQVRIFRKAGSDLEVIYRQRWHQTHPNSEFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U7</accession>
    <name>K9Z4U7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219339.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1499"/>
    <dbReference type="EnsemblBacteria" id="AFZ53610">
        <property type="protein sequence ID" value="AFZ53610"/>
        <property type="gene ID" value="Cyan10605_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1499"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2342077_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10621" checksum="E54E3EF5BC685012" modified="2013-03-06" version="1">MGTAATDVQNRDIPGAYLFASEEESKSIRDNHSNFIEEGIAFYAASAGSSTGSGIYRFQSLVNPGAYIFVGEQERQNIIQNYSDVFVEEGIVFEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z1</accession>
    <name>K9Z4Z1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1704"/>
    <dbReference type="EnsemblBacteria" id="AFZ53807">
        <property type="protein sequence ID" value="AFZ53807"/>
        <property type="gene ID" value="Cyan10605_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1704"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1810"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_3"/>
    <dbReference type="OMA" id="PAITHQT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="101"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="506" mass="57689" checksum="EF6F20747CEB1799" modified="2013-03-06" version="1">MGKSLLFDLYDYSMSRTTRLTYDRGTLILHPPPRGKAWIDYATWDDRIEKFRIQALDYRYLIETLQSEDIDLIDSAKEFYPLDIKLQGNKTPYPHQKEALEAWKQAQRQGVVVLPTAAGKTFLAQMAIASTPRTTLIVVPTLDLMHQWYAEIKASFSNIEVGLLGGGSHDRTPILIATYHSAAIHAKTLGNHYGLLIFDECHHLPTDFFQVIAEESIAPYRLGLTATPEREDGGHHYLNRLIGSVIYRKTPEELSGKTLAQHQVISLKVKLKKEEKQRYEQAIKTRNNFLKQNNISLSSLQGWQLFVQASCRSNQGRQAMLAHREAKEISMGTQGKLRLLTELIEKHYPDKILIFTNDNNTVYKISQEYLIPAITYQTPVKERHEILQKYKEGDYKIIVASHVLNEGVDVPSAKIAIILSGTGSTREYIQRLGRILRKANQGEKFAILYEIVAEDTSEEKTSARRKGETNYSVNKPNNNQGEIIFYPQINQGLRAAEPKTTWGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z7</accession>
    <name>K9Z4Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)H-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="7">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H dehydrogenase I subunit N</fullName>
            <shortName evidence="7">NDH-1 subunit N</shortName>
            <shortName evidence="7">NDH-N</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ndhN</name>
        <name evidence="8" type="ordered locus">Cyan10605_1375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the complex I NdhN subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219217.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1375"/>
    <dbReference type="EnsemblBacteria" id="AFZ53488">
        <property type="protein sequence ID" value="AFZ53488"/>
        <property type="gene ID" value="Cyan10605_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1375"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1452"/>
    <dbReference type="eggNOG" id="ENOG502ZBMI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087432_0_0_3"/>
    <dbReference type="OMA" id="HGIRPPH"/>
    <dbReference type="OrthoDB" id="1804108at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01353">
        <property type="entry name" value="NDH1_NDH1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020874">
        <property type="entry name" value="NAD(P)H-quinone_OxRdtase_su_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35515">
        <property type="entry name" value="PTHR35515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11909">
        <property type="entry name" value="NdhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="1 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17213" checksum="D2EB0C709D307861" modified="2013-03-06" version="1" precursor="true">MPLLTTGKAFIKDLEKAGSVAVYAPLEGGFEGRYQRRLRSYGYQTFNLSARGLGDLSAYLMNVHGVRPPHLGKKNIGQEGAVGPTYFVPPIAGYQLENLPAKAKGLVLWIIEGFVLSNQEKQYLVDLTKQEPKIKVVLELGGDRFFRWQSLSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z552</accession>
    <name>K9Z552_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219272.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1432"/>
    <dbReference type="EnsemblBacteria" id="AFZ53543">
        <property type="protein sequence ID" value="AFZ53543"/>
        <property type="gene ID" value="Cyan10605_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1432"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155150_0_0_3"/>
    <dbReference type="OMA" id="NELAQEW"/>
    <dbReference type="OrthoDB" id="1990688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13848" checksum="6F27E87F7531B6A0" modified="2013-03-06" version="1">MENNNLINFVQQGFRTVVGATASAIETLQDNNKRNQIVSELTTELQKKSQEWQEKGALTEEEAKKIIEQFFQNKSENTNNNPNYDETVETKAENNPYQNIQQLTQEVIALREELEKIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z579</accession>
    <name>K9Z579_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53568">
        <property type="protein sequence ID" value="AFZ53568"/>
        <property type="gene ID" value="Cyan10605_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1457"/>
    <dbReference type="eggNOG" id="ENOG50346FD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449694_0_0_3"/>
    <dbReference type="OMA" id="WSYNTRT"/>
    <dbReference type="OrthoDB" id="1983118at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10425" checksum="EC42F7DC156141FB" modified="2013-03-06" version="1">MKIGLNLKFFNGFGSLLGGMAIRLVKFFPVYVIIFIAYGDKFLPSPLNQWSYNTRTTINSVLVGSFNEDVLQNNKYNNKKSDEIIKQIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C3</accession>
    <name>K9Z5C3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219669.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1840"/>
    <dbReference type="EnsemblBacteria" id="AFZ53942">
        <property type="protein sequence ID" value="AFZ53942"/>
        <property type="gene ID" value="Cyan10605_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1840"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_3_0_3"/>
    <dbReference type="OMA" id="NRFLECA"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15999" checksum="64F25418CEA20E1C" modified="2013-03-06" version="1">MNLKKIILDTNILISAILNPDGTARKTLEKAYGQFTIVQSEETYQELKTRIYKPKFDKYISNAEREDFLTAMQNNSLFIQTISKISDCRDMEDNKFLELAKDAQAICLITGDKDLLTLKSLNQYQNLIITAREFMELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H7</accession>
    <name>K9Z5H7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219542.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1712"/>
    <dbReference type="EnsemblBacteria" id="AFZ53815">
        <property type="protein sequence ID" value="AFZ53815"/>
        <property type="gene ID" value="Cyan10605_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1712"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1819"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_3"/>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="33189" checksum="6A4D0101133E9DBA" modified="2013-03-06" version="1">MREKITILKENLARTIVGKDDAIKLVLVALLSGGHALLEDVPGVGKTLLAKSLAKSINGKFQRIQCTPDLLPSDVTGTNVWNPNSREFEFLAGPAFANVLLADEINRATPRTQSALLEVMEEKQITIDGVAKIVPIPFFVIATQNPVEYQGTFPLPEAQMDRFAISLSLGYPSFEEELQMLEKQLNPTLVEELEPCVSLQDVKDLQKEVFSVRVAPEIQKYIVNLINASRQDDDIALGVSPRGTIALQKASQALAFLEGRDYVIPDDIKFLAPSVLSHRLIPAGGRNAKVIVARLLNTVAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M7</accession>
    <name>K9Z5M7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2371"/>
    <dbReference type="EnsemblBacteria" id="AFZ54454">
        <property type="protein sequence ID" value="AFZ54454"/>
        <property type="gene ID" value="Cyan10605_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2371"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2518"/>
    <dbReference type="eggNOG" id="ENOG5032Z8S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186202_0_0_3"/>
    <dbReference type="OMA" id="NLGEWWR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8617" checksum="25C22576BBABF37C" modified="2013-03-06" version="1">MMNSEDLAKYIEQSQGISKPWLLIQLRLKKLEESKDSLSETEYINQLMDIHQDLMKLGEWWIGREDEVFGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V4</accession>
    <name>K9Z5V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane transport energization protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219847.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2031"/>
    <dbReference type="EnsemblBacteria" id="AFZ54122">
        <property type="protein sequence ID" value="AFZ54122"/>
        <property type="gene ID" value="Cyan10605_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2031"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2158"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_3_2_3"/>
    <dbReference type="OMA" id="KFRRKPR"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="14405" checksum="94581C87707C7461" modified="2013-03-06" version="1">MRIPDEQDVQGEINIVPMIDAIFSILAFFIISSISLIRSEGLPVNLPSAKTTESQKVAQINVTIQPDGKVFLNKQPIEVNGLQGAVTKLIPNSEQSMVIINADEKVSHGIVVSVMDELRQIKGVGLAISAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W8</accession>
    <name>K9Z5W8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220262.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2458"/>
    <dbReference type="EnsemblBacteria" id="AFZ54539">
        <property type="protein sequence ID" value="AFZ54539"/>
        <property type="gene ID" value="Cyan10605_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2458"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2603"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031866_1_0_3"/>
    <dbReference type="OMA" id="WVQGGIQ"/>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="411" mass="45845" checksum="EFAE45F219D63EA8" modified="2013-03-06" version="1">MSIIKPQVQFICLRDAIASDSVTNLDVIVRITIPEIQTNRQRPPLNLGLVIDRSGSMGGDKIRYARQAAIYAVQQLSESDRISVTIYDDQVEVIIPSQHATDKQNIINRINGITPRNMTALYDGWLEGATQVSKYLQPERLSRVILLSDGLANVGETNPDVIGNDVNGLSKRGVNTTTMGIGDDFNEDLMQGMALSGDGNYYFIQNPDQLPSIFNAELQGIMATIGQKVSLGIKTFAPVELVDVFNDLDKTEFGNYKLPNLVAGNDIDVVLRLKIPPMTNSVPLVDFRLAYDDNETQSRKVTHHQLQLPVVNSAQLHDYLFNEEVKAKVAQLMASRAKEEAIASLDRGDVWGTKERLQEAKEEMMSSGVCFDMIAPEVAEIDNLLENLERGESKSMRKKALFQNYSKRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C1</accession>
    <name>K9Z6C1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219685.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1857"/>
    <dbReference type="EnsemblBacteria" id="AFZ53958">
        <property type="protein sequence ID" value="AFZ53958"/>
        <property type="gene ID" value="Cyan10605_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1857"/>
    <dbReference type="HOGENOM" id="CLU_2536958_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9663" checksum="C0D582E2B3ACA493" modified="2013-03-06" version="1" precursor="true">MKQIFNVFYLIAFIYSISLSAYVGWWILRDWKALDYSHNVEKNYDISIHHRINLAGEAPVFLLLNCLTAMSVIGLNINNRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I6</accession>
    <name>K9Z6I6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219743.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1922"/>
    <dbReference type="EnsemblBacteria" id="AFZ54018">
        <property type="protein sequence ID" value="AFZ54018"/>
        <property type="gene ID" value="Cyan10605_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1922"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127714_0_0_3"/>
    <dbReference type="OMA" id="GASHPQW"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="178" mass="21118" checksum="4433E2FB6948CBBF" modified="2013-03-06" version="1">MTLNSIDKLLNSILSQPQWEKQRRYYELKKIWYEIVNQKIAQHTSPIYLKEEVLFIATQSAVWAQELSLQRRTLIIKINRRIQNPIKDIYFVFGKWYSQNTPPIPEAETNLSHPSLVESTEFITQPKETPQEALQQWFEIIKQRAKNNSTCPCCQSFCPEGELNRWGMCAYCFRENNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I8</accession>
    <name>K9Z6I8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220529.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2734"/>
    <dbReference type="EnsemblBacteria" id="AFZ54806">
        <property type="protein sequence ID" value="AFZ54806"/>
        <property type="gene ID" value="Cyan10605_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2734"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2900"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_3"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36323" checksum="A8C445AA13D6367F" modified="2013-03-06" version="1">MAETLMFNALRQAIDEEMARDDKVFVLGEDVGHYGGSYKVTKGLYQKYGEFRVLDTPIAENSFTGMAVGAAMTGLRPIIEGMNMGFLLLAFNQIANNAGMVRYTSGGNFKIPTVIRGPGGVGRQLGAEHSQRLEAYFQAVPGLKIVACSTAYNAKGLMKSAIRDDNPVLFFEHVLLYNLKENLPDYEYTLPLDKAEIVREGKDVTILTYSRMRHHCLQALKQLEKDGYDPEIIDLISLKPLDMETIGESVRKTHKVIIVEECMKTGGIGAELTASINDQLFDELDAPVIRLSSQDIPTPYNGTLERLTIVQPEQIVDAVRKIMNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z722</accession>
    <name>K9Z722_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220265.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2461"/>
    <dbReference type="EnsemblBacteria" id="AFZ54542">
        <property type="protein sequence ID" value="AFZ54542"/>
        <property type="gene ID" value="Cyan10605_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2461"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2606"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_3"/>
    <dbReference type="OMA" id="CGVNTAK"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="258" mass="30427" checksum="76A7624AF2EA6318" modified="2013-03-06" version="1">MTTLKTHSEYKQENEKLFVNYRQNRDLRVRNQILELNMGLVRKEVCHWLNQCQENYDDLLQVGCIGLIRAIDRYDIEKGFAFSSFAVPYVRGEIQHYLRDKGYSIRIPRRCLELKNQSNRIVRKLRNELNRQPTDQEIARELGVSLQEWHDVKLAHQNREPISLDINANDEDERSTLGDCLPDHQYRSFQLAQEDKIRLQNALSQLEDGTRKVLEFVFLQDLTQKETADILGVSVITVSRRIKKGIVKMRNLIKPDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z732</accession>
    <name>K9Z732_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220674.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2888"/>
    <dbReference type="EnsemblBacteria" id="AFZ54954">
        <property type="protein sequence ID" value="AFZ54954"/>
        <property type="gene ID" value="Cyan10605_2888"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2888"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3069"/>
    <dbReference type="eggNOG" id="COG4938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032548_0_0_3"/>
    <dbReference type="OMA" id="LLLMKQT"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="53965" checksum="59ED79B117776BA7" modified="2013-03-06" version="1">MLTKIELENFKCFKENTVFPLGKLTLLTGINGRGKSTLLQSLLLMRQSIEYDHQTTQLILNGNCLSLGRFEEIRNTGISRQEPIIFRYYFTDKFQFHDYTETTFNRIVDYSFIEDTVDDLVAQLNHIKLQEEVIWTFFDTQNQNFTFKIDELYKPTKADNFVARTNSVEHCLFEPYDFQEKSGDSVSRLSNFFPYSATNRTFKIPINQLKNIARKIKSSSKNTNYWECQINGTIIFNLNKIHYISADRLGPQDFYFKSTLPKFPNVGLRGELTGNLLYRKKDQLVNDKLCLGEDAKTLIIQTQEWLNKIFDGAKVEISGTQTNILELMFNASLSKDRFRPANIGFGYHCILPIIVSGLIAQEGEILIVENPEAHLHPKAQSELAKFLAKVSSCGVQVLIESHSDHILNGLRIAVLDEILSHEDLSILYFSQKIGESVVQIPVHSDGKIEEWPEGFFDQMDKDFERLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z736</accession>
    <name>K9Z736_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220280.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2476"/>
    <dbReference type="EnsemblBacteria" id="AFZ54557">
        <property type="protein sequence ID" value="AFZ54557"/>
        <property type="gene ID" value="Cyan10605_2476"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2476"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2625"/>
    <dbReference type="eggNOG" id="ENOG5032H5C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515475_0_0_3"/>
    <dbReference type="OMA" id="DWVIMPS"/>
    <dbReference type="OrthoDB" id="1906218at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="171" mass="19331" checksum="AB3E7A7ACEDD74C6" modified="2013-03-06" version="1">MFNIAFSHDHNRQINWSAIILFTLGFWLSASFVLDFVLIPSLSVTGMMTESGFASAGFVIFGIFNRVELICASLVLTTALVFGSQHYFTQRKQVLSIIFSSLLLAIALAYTYVFTPHLTAWGLCLNQFGVNQTMPTNMISWHEGYWFLELVKYILAGTLLRWSYQGLLGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z776</accession>
    <name>K9Z776_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_2341</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220149.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54425">
        <property type="protein sequence ID" value="AFZ54425"/>
        <property type="gene ID" value="Cyan10605_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2341"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2486"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="ECCPLTC"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="346"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="485" mass="55929" checksum="8E80D24D9C592116" modified="2013-03-06" version="1">MNKAYKYKLKPSHYQQRMMANWLDMLRSYYNYCLRDRIESYEQVKQPKLGNYCDLRTKAECCPLTCSVSKNSQLGEPFKGDKKRSAYEMQSSELPNLKKTRSWYKQIHSTVLQQNLRKLDTAFKNFFDGRGYPKFKTRQRFKSFNYPPNQVKLKGNKIYLPSIGWMRFFQSRQIPEGFSLRSVTVRQKADGWYVSISIEDKSIPQSQPKDLAQVKSLIGCDLGIKKLLALSNGEQINNPQFEKQLERTKTIRQRRASRKKRGSKNQKKAYQKLARIDQKIVNQRTNYQWNIAHHLTRLADVIVLEDLNIQGMSKRCKPKQDENGKYLKNNQSAKRALNRLIRDCSWGELKLKIQSVAEKFGCIVLEVNPKFTSQTCSNCGHIDSASRNKEKFVCTNCGFIADADNQASVNIGMKGLEILGISPSKLLVDNQKVTAKSELTDSSKKREKSMALVVEPSNPRQLELFQWINGQVTGCSESPVTARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z783</accession>
    <name>K9Z783_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220325.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2521"/>
    <dbReference type="EnsemblBacteria" id="AFZ54602">
        <property type="protein sequence ID" value="AFZ54602"/>
        <property type="gene ID" value="Cyan10605_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2521"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2673"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019510_0_0_3"/>
    <dbReference type="OMA" id="CWTDLIQ"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="596" mass="65857" checksum="B858036B23A9240E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z790</accession>
    <name>K9Z790_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LapA_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220785.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3006"/>
    <dbReference type="EnsemblBacteria" id="AFZ55066">
        <property type="protein sequence ID" value="AFZ55066"/>
        <property type="gene ID" value="Cyan10605_3006"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3006"/>
    <dbReference type="eggNOG" id="COG5416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161803_0_0_3"/>
    <dbReference type="OMA" id="NDPLFDW"/>
    <dbReference type="OrthoDB" id="2064316at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="12156" checksum="CC43C7ED22DE4CBF" modified="2013-03-06" version="1">MGITKKLFINLIISFWLILIAVFSIQNIDKVSLKFFMFESISIPIGVLLSIMVAIGFILGWLLPVFFTNKSADNKRKNLNRSNRQRTEFSRDLQEENDPLFDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A6</accession>
    <name>K9Z7A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3022"/>
    <dbReference type="EnsemblBacteria" id="AFZ55081">
        <property type="protein sequence ID" value="AFZ55081"/>
        <property type="gene ID" value="Cyan10605_3022"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3022"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3220"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582307_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938644" evidence="1">
        <location>
            <begin position="31"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="310"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="416" mass="44391" checksum="E1DB3312A19487E4" modified="2013-03-06" version="1" precursor="true">MKLKCLSQRLSSAGFILALGLIASPESVSATVLESVKTNTQEFFQPTLLVNSAEQVSILTENTSGLKTDSNSNSIVARATSNSSNINNGVVTENNVSRVITPSFDQRLKTSATSFKSAGKFTVADNHIISGNQGQSLSIPVNSVESPNLIKTESVSIPIAIENSDNSAGVSAVNIPVVPSAKDSFIKQQTESNTTNNVITLDVEEPTFISNGDINANSTANENNINLISASSQDNFEDSSQNSNLVSVVPIQIEYYDPTMSPAVGDIGSPNLPQLNSPDPYLPESQRPFRGYIWPAKGVFTSGYGWRWGRMHRGIDIAAPVGTPIFAAADGEVITAGWNSGGFGNLVKIRHYDGSVTLYAHNSKILVRRGQNVTQGQQIAKMGSTGFSTGPHLHFEIHPNGSKAVDPIAFLPKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C6</accession>
    <name>K9Z7C6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ordered locus">Cyan10605_2562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220365.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2562"/>
    <dbReference type="EnsemblBacteria" id="AFZ54642">
        <property type="protein sequence ID" value="AFZ54642"/>
        <property type="gene ID" value="Cyan10605_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2562"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2719"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_3"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLU5KINASE"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="49"/>
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        <ligand>
            <name>substrate</name>
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            <name>substrate</name>
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            <end position="169"/>
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        <ligand>
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            <end position="217"/>
        </location>
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        </ligand>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54642.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="370" mass="39562" checksum="8E28D26C20E09100" modified="2013-03-06" version="1">MSKTIVVKIGTSSLTRLETGNLALSTIASLVETLTNLRQQGNRVILVSSGAVGVGCGRLCLTERPRNINIKQAIAAVGQGRLIRVYDDLFSNLGQPIAQILLTRRDLMDRNSYVNANNTFNALFELGVIPIVNENDTVATDELKFGDNDTLSALVASLVEADWLFLLTDVDKLYSADPRIVPSAVPIDLVNSDEFAQLEINVSEGGSGWGTGGMITKLRAAKIASSAGVTTVITNGKTPYNISKIIAGEAIGTKFTAQPKTENARKRWIANGLVSTGRIHLDDGAVNALCKQGKSLLAAGITTIEGNFSVSDAVDLINSQGEIIGKGIVNYSYDDLDLVKGQKSANISQILGYQTPETVIHRDNLVIFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D1</accession>
    <name>K9Z7D1_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">12-oxophytodienoate reductase</fullName>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="364" mass="40177" checksum="F830609720EB2E6D" modified="2013-03-06" version="1">MENFNLFSPFSLGGYTLPNRIIMAPMTRLRATDEGIPTETMATYYAQRATAGLIITECTMISPSAHGYLNCPGIYNQAQIDGWKLVVEKVHQQGGKIFLQLWHCGRVSHPSLLQGEMPIAPSAIPAQGQLHTPNGKVSLEKPRALNLDEIPTIVKEFQQAALNAFHAGFDGVELHGAFGYLIDQFLQDVSNQRTDEYGGSIANRSRFLLEVVEAVIEVWGDNKVGIKLSPTNTFYGMLDSNPIPLFTYVLQALNQYNLAYVHLMEASEMDLQNENAIPSVLDTFSGFYNGTIITNGGYDKTKADKAISSQKASLVSFGRPFIANPDLVERLAINAPLTEVNMKTLYGQGNHNAEEGYTDYPFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K3</accession>
    <name>K9Z7K3_CYAAP</name>
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        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ55129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3072"/>
    <dbReference type="EnsemblBacteria" id="AFZ55129">
        <property type="protein sequence ID" value="AFZ55129"/>
        <property type="gene ID" value="Cyan10605_3072"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3072"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3275"/>
    <dbReference type="eggNOG" id="COG0057">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_3"/>
    <dbReference type="OMA" id="NAKVLAW"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="36680" checksum="6A2F18F8E79F0F06" modified="2013-03-06" version="1">MVRVAINGFGRIGRNFLRCWLGRENSGLEVIGINDTSDPHTNAHLLKYDSMLGRLDADIQADENSIIVNGKTIKCVSDRNPLNLPWKDWDIDLIIESTGVFVTEEGASKHIEAGAKKVLITAPGKGGNIGTYVVGVNDKDYEHDKHNIVSNASCTTNCLAPIVKVIHEHFGIIKGTMTTTHSYTGDQRILDASHRDLRRARAAAVNIVPTSTGAAKAVALVIPEMKGKLNGIALRVPTPNVSVVDLVAQVEKKTIAEEVNSVLREAASSSMKGILDYTDLELVSSDFRATDCSSTVDGKLTLVLDGDMVKIVAWYDNEWGYSQRVVDLAEIIASNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N9</accession>
    <name>K9Z7N9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxysome shell protein CcmK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbon dioxide-concentrating mechanism protein CcmK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccmK</name>
        <name evidence="7" type="ordered locus">Cyan10605_3135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Interacts with CcmN and CcmO in the carboxysome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The tight homohexamer forms a small pore which is positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial microcompartments protein family. CcmK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220905.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3135"/>
    <dbReference type="EnsemblBacteria" id="AFZ55186">
        <property type="protein sequence ID" value="AFZ55186"/>
        <property type="gene ID" value="Cyan10605_3135"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3135"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3341"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_0_3"/>
    <dbReference type="OMA" id="ESWVIIP"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00854">
        <property type="entry name" value="CcmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046380">
        <property type="entry name" value="CcmK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 5" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="6">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="12212" checksum="9806D1616E60A424" modified="2013-03-06" version="1">MPSQSAVGSLETKGFPGVLAAADAMVKAGRVTLVGYIRVGSARFTVNIRGDVSEVKTAMAAGIDAVEKAEGAALESWVIIPRPHENVCAVLPIDYSESVEPYRQAVEGIALPSARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R2</accession>
    <name>K9Z7R2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220934.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3165"/>
    <dbReference type="EnsemblBacteria" id="AFZ55216">
        <property type="protein sequence ID" value="AFZ55216"/>
        <property type="gene ID" value="Cyan10605_3165"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3165"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3373"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_6_1_3"/>
    <dbReference type="OMA" id="CGADLCD"/>
    <dbReference type="OrthoDB" id="1545520at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="20138" checksum="92AC7F636BC43BC8" modified="2013-03-06" version="1">MSKSYTLDIENIRHGNIKDLQAINLNGANLSGADLAQSNFTGSNLTGVNLTGANLEKAILRCNLRGADLTGASLQGADLRGADLRGAILLSSQVENISLAGSFLAGAILTNLDLCNADLRGADLRGVNLVGACLQKADLSNANLSGADLSQADLEEANLSGAILHGTNLTQANLLCAIVEGVSFDYVITSETIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R9</accession>
    <name>K9Z7R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2704"/>
    <dbReference type="EnsemblBacteria" id="AFZ54777">
        <property type="protein sequence ID" value="AFZ54777"/>
        <property type="gene ID" value="Cyan10605_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2704"/>
    <dbReference type="HOGENOM" id="CLU_3097934_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="51" mass="6249" checksum="65D47266DCCBC728" modified="2013-03-06" version="1">MYYLDLASSQKWTDEIREQEIVIRIDKKLIIIIDFKKLVFWCFCTGTRSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S8</accession>
    <name>K9Z7S8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220898.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3128"/>
    <dbReference type="EnsemblBacteria" id="AFZ55179">
        <property type="protein sequence ID" value="AFZ55179"/>
        <property type="gene ID" value="Cyan10605_3128"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3128"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3334"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_3"/>
    <dbReference type="OMA" id="RPAFQVG"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="59"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="485" mass="55923" checksum="58CCF869268953FF" modified="2013-03-06" version="1">MSIFNQNYLRSETNNNLYSNGKYTPVVALKELVASLQREQNKIQNLLSSLSFALRSFNNLNQFLELTPLMVARVTDADGGALILYRQQEISLEQIYCHNNRWREEITFSFQELVQEINTYSQTCQHDPSLCPEIECFSDFVESQVQSRFSPLFPIFSTPIIVKNVERGRFYVFSQDSEYVWTQTRRKLAQLVADQTAVAIANHELTVELRSKERQDRELEIASEIQLRLLPRKCPTIKGLEVAAKCQTANRVGGDYYDFIPVNYDQWDENNATNKNAPCEPWSIVIGDVMGKGVPAGLIMTMTRGMLRAEVLNRHSPSRVLEHLNRVMYPDLENSHRFVTLFYSEYDPQTHLLRYANAAHNPPLLWREGKSNLIPLDTEGMLIGLEPNSHYQDDCLQLQPNDTILYYTDGLTDAVNQNNQRFEEENLIKCFRYGCENYNTAEEILNYILKTIENFIGIGNRNSDDITLVVVKFNPDHSFTCQCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V8</accession>
    <name>K9Z7V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220932.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3163"/>
    <dbReference type="EnsemblBacteria" id="AFZ55214">
        <property type="protein sequence ID" value="AFZ55214"/>
        <property type="gene ID" value="Cyan10605_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3163"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3371"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_3"/>
    <dbReference type="OMA" id="ENQLLWC"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="425" mass="49616" checksum="CA2FF52924595175" modified="2013-03-06" version="1">MINFLLGLAIGLFIYFWNAYRANCQLKEILYSLSEFDSVKSLSKIAQVRRGVNLLNNKFYYTQLELDVHHELIRKNPLGYLRIDANNCLIECNEEAKKILYIQRWNPQILRLFLELVRSYELDQLIQQTRKIQKRLTIEWQFFPTANYIAEEENLDTNSYQPLFLKAYSYPLPAGQVGIFIENRQLIRELTQKKEQAYSDLSHELRTPLTSLLLLSETLQKFTDDKGKIWLEQLHKEINRLVDLVQNWLEIYQLEQNPYQTLKFQSLDLQQLLLSAWQSVTILAGKKEISYKYEGEDKIFIDVDLNRFTQVFVNLFDNSIKHCFFGGSILVKAQIKTNIYEEEVVEIHVIDNGSGFNPNDLPHIFERLYRGDKSRMRTARGGSGLGLSIVKQIIEAHQGSIAASNHPETKGAWFKIIVPLKQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W8</accession>
    <name>K9Z7W8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220947.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3178"/>
    <dbReference type="EnsemblBacteria" id="AFZ55229">
        <property type="protein sequence ID" value="AFZ55229"/>
        <property type="gene ID" value="Cyan10605_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3178"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3387"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OMA" id="INHEDSK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="309"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="460"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="720" mass="82649" checksum="9AA143D81FAD1554" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z817</accession>
    <name>K9Z817_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221007.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3243"/>
    <dbReference type="EnsemblBacteria" id="AFZ55289">
        <property type="protein sequence ID" value="AFZ55289"/>
        <property type="gene ID" value="Cyan10605_3243"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3243"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3457"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545948_0_0_3"/>
    <dbReference type="OMA" id="GKISWAG"/>
    <dbReference type="OrthoDB" id="572465at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="509" mass="57502" checksum="A7360B36CE4258E1" modified="2013-03-06" version="1" precursor="true">MISTNNLREPIDKICFFLIAIFSFIIVLLISSTKFCYEGKCLFNNNPEVKEFSWQDKKIGSIDKAFYLVFDRPMSHESVEANLRIEPSLEGKISWSGKRLVYTLERVIPYGRNYRLSLQKAQEKFRGKEELGAEIEPFIAEFQSRDRAFAYIGSQGEESGRLILNNSTKQNKTILTPENLTVVDFKFTKNSEKIIFSAVNEDNDNADFKQVDIYEVTTGLSNDLTPKIPGELKLILNGKEYQNNQFDLAGENQEIIIVQRIKHNDPLDFALWKIAPNKVPEKLDTEGGDFTITPDGKGIAIAQGEGIAILPIESENQEKIINFLPKYGQVLTFSNDGSSAAMINFNKDNSELRYTRSLFYVNNQGVEKELINIKGSIIDCKFNDNGNQLFCLLTELMQTETELIEKPYFVAIDIQSGKIIPLVALPKYQDIKISVAPDGLGILFDQLITENDLPKKALKNLPTNEDLLTNSAELIVGSRLWLLTLPTSESPQAKLEELPISGFKPQWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z851</accession>
    <name>K9Z851_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">Cyan10605_2671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220468.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2671"/>
    <dbReference type="EnsemblBacteria" id="AFZ54745">
        <property type="protein sequence ID" value="AFZ54745"/>
        <property type="gene ID" value="Cyan10605_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2671"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2836"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_3"/>
    <dbReference type="OMA" id="YYVGSFY"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023843">
        <property type="entry name" value="CRISPR-assoc_Cas1_cyanobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04093">
        <property type="entry name" value="cas1_CYANO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="335" mass="38608" checksum="3912992311E7A1DF" modified="2013-03-06" version="1">MGTIYITKDDTFIGKIDERIHVKADRKQILDVPFIKVDGLVILGRSNFSPALVAELLERKIPMSFLTTTGKYLGRLEPELTKNIFIRKAQWKTEDNSEKALHIVKGFIRGKLKNYRNFLQLRNRQNNHEKLEISINQIQDIIDGLERKNNVNSLRGLEGAGSAIYFSCFNLLIKNNEFSFNTRNRRPPTDPVNSLLSLGYALLRHDIQSAVNIVGFDPYLGYLHVAHYGRPALALDLMEEFRPIVTDAVVLNVINNKKITPKDFIIEPLSNAVSLTKEGLQIFLRAYEEKKQSKFKHPVLNRQCTYQESFEIQARFLAKYLMDETKQYPPLIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z863</accession>
    <name>K9Z863_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2856"/>
    <dbReference type="EnsemblBacteria" id="AFZ54922">
        <property type="protein sequence ID" value="AFZ54922"/>
        <property type="gene ID" value="Cyan10605_2856"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2856"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_15_1_3"/>
    <dbReference type="OMA" id="PIELEWQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22713" checksum="7D1C7C0CB5999214" modified="2013-03-06" version="1">MKQKRADLEMLEIAAALGEIDLLYGDESGFCCWSEATYSYYFCGEQKRQEQTKKRGKRLSIMGIWQPLAEFFYGLVVGSLKSEEFIVMMDQQAKIAQAQKRMRVVVLDNGSIHVSKKVKEKYQDWEAQGLYFFFLPAYCSQMNPIELEWQHLKEEELAGQMFESEKELACHVIWGLESRGEKNNHNLKFINLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B0</accession>
    <name>K9Z8B0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220686.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2905"/>
    <dbReference type="EnsemblBacteria" id="AFZ54967">
        <property type="protein sequence ID" value="AFZ54967"/>
        <property type="gene ID" value="Cyan10605_2905"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2905"/>
    <dbReference type="eggNOG" id="COG3105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782369_0_0_3"/>
    <dbReference type="OMA" id="GRIDNRT"/>
    <dbReference type="OrthoDB" id="1712289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="40777" checksum="A7B7FBB10500C231" modified="2013-03-06" version="1">MSKIFIETRGTSEVYNWFDALESNKKQLPQLPELVKKLADTEFESLVLYRESRQLILAITALKSGRIDNRTRPIRNSLIWIDDNDEEAKIRAIIYEYLTAKDGLEKDIADAITETPEIKIDYQKIESIGNNNLESNALNSARLIYKIGNLDKYKQELIDEIKSCSLPKEKGLLVFITNSKSQKTFEEAKPWRGLSNNISSEGWIILENKNKKPVVNEKKTKKQTSQISTKSFTDSEKSLTKSNKTERTLLNIFSIILVLLLVSNAFLLYKINELEKKINQIENLQSVIDKSKTDVEKLTTNLENDIVTAKDKFEKAFMEAQKQFNDDIFKATSKYETEMAKVQQRLSDSIERIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G1</accession>
    <name>K9Z8G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ordered locus">Cyan10605_3441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221199.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3441"/>
    <dbReference type="EnsemblBacteria" id="AFZ55481">
        <property type="protein sequence ID" value="AFZ55481"/>
        <property type="gene ID" value="Cyan10605_3441"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3441"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3666"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_3"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="33"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="600" mass="67080" checksum="28AD07C6F37685FA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G7</accession>
    <name>K9Z8G7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem I assembly protein Ycf3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ycf3</name>
        <name evidence="6" type="ordered locus">Cyan10605_3407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for the assembly of the photosystem I complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ycf3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221167.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3407"/>
    <dbReference type="EnsemblBacteria" id="AFZ55449">
        <property type="protein sequence ID" value="AFZ55449"/>
        <property type="gene ID" value="Cyan10605_3407"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3407"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3630"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141248_0_0_3"/>
    <dbReference type="OMA" id="VYYRDGM"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00439">
        <property type="entry name" value="Ycf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022818">
        <property type="entry name" value="PSI_Ycf3_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2" evidence="4">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3" evidence="4">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="173" mass="19785" checksum="7ADA33641C68A2E8" modified="2013-03-06" version="1">MPRSQRNDNFIDKTFTVMADIILKVLPIDSKAKEAFVYYRDGMSAQAEGEYAEALENYEEALKLEEDPNDRSEILYNMGLIHASNGKLEEALGYYHQSLDLNPRKPSALNNIAVIYHHLGEKSKQAGNENEAESLFDKAAEYWKQAIRLSPNSYLEAQNWLKTTGRSEIDVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M3</accession>
    <name>K9Z8M3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">Cyan10605_3478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221232.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3478"/>
    <dbReference type="EnsemblBacteria" id="AFZ55514">
        <property type="protein sequence ID" value="AFZ55514"/>
        <property type="gene ID" value="Cyan10605_3478"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3478"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3704"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_3"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="14672" checksum="62CAFF53D17E38C0" modified="2013-03-06" version="1">MTLEYPEDLRYLDSHEYVRLDGEIATIGITAFAIEELGDIVFLELPELGDAIEVEDNIGTIESVKAVSEIYAPVAGTVIDRNDMLIESPEAIADDPYGEGWLIKVRLDNPDDELENTLSVQEYRSLIEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q9</accession>
    <name>K9Z8Q9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220461.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2664"/>
    <dbReference type="EnsemblBacteria" id="AFZ54738">
        <property type="protein sequence ID" value="AFZ54738"/>
        <property type="gene ID" value="Cyan10605_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2664"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2829"/>
    <dbReference type="eggNOG" id="ENOG502Z7MJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955452_0_0_3"/>
    <dbReference type="OMA" id="KQRAMHP"/>
    <dbReference type="OrthoDB" id="921768at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="291" mass="32542" checksum="920F6F14EAEC9709" modified="2013-03-06" version="1">MTTGLPKTDQEKVHFDIYAILEGSQELYFGHETQVNINLVETVKLSTKNGEDLEKCYLSPTKRRGIERRCLIWAPVKSLGKLLGDKLDCGIPKTCVKIDCPICSTYGGLKVGEKTLIGRVSHGGGVAIQPILPEQKQRAMHPSRIASPESGKDETPTPFKREYNQPGILYPVYNHCLSLTDEDFATVAYAFLDSLPRIGAGNPKGIGLAEDAEKLLLVVDRYLVPKGKRPIISPSETNPESAIENFWRLAQTPEENTDYIQVKHFERWIGDKALEKLQEYASIFVDEVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R0</accession>
    <name>K9Z8R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Curli production assembly/transport component CsgG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220831.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3055"/>
    <dbReference type="EnsemblBacteria" id="AFZ55112">
        <property type="protein sequence ID" value="AFZ55112"/>
        <property type="gene ID" value="Cyan10605_3055"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3055"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3255"/>
    <dbReference type="eggNOG" id="COG1462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068064_0_0_3"/>
    <dbReference type="OMA" id="IGSVTQF"/>
    <dbReference type="OrthoDB" id="1319623at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939151" evidence="1">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="35193" checksum="67E22F330BE47F39" modified="2013-03-06" version="1" precursor="true">MKKHFYPKNFSFLLIGILLSAFAIETNINFVKANPSPSIVAQTTNDEKIRVAVLDFDYSAVSNPTWLSYFNGGAKGVSDMIVNQLVETGKYRVIERSRLDAILAEQNLGASGRVDASTAAEIGRLLGVEMVVIGSVTQFDIEKRGSNFGLFGVSVGNESSEAYVTLNSRIVNTNTGEILMTAEGKGVANQSDDNVRVFTIGGGTSTSNETKLLTVATQEAVKGIVSKMSENEAKLAAVPKVLPNIDAVVADVSGGTVVLNKGSQDGYRTGMKVSIERVGKEIKDPETGKVIRRLTTAIGVVELYDVDTSSSLGKIISGNGFKVGDVATPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T7</accession>
    <name>K9Z8T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220496.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2700"/>
    <dbReference type="EnsemblBacteria" id="AFZ54773">
        <property type="protein sequence ID" value="AFZ54773"/>
        <property type="gene ID" value="Cyan10605_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2700"/>
    <dbReference type="eggNOG" id="ENOG5033BAI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169707_2_0_3"/>
    <dbReference type="OMA" id="WYQGLAT"/>
    <dbReference type="OrthoDB" id="2001195at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11473" checksum="812765ED0A327649" modified="2013-03-06" version="1">MNSNQQPQWKKKLEEIEAEISNSSQNPLNAINSEKSKNIFMQVKNWFISLPAVGKVIVGLFGFAVTISLLKAVFSLVQLAISLAFLSVIVYFVYQFFIKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V8</accession>
    <name>K9Z8V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220521.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2726"/>
    <dbReference type="EnsemblBacteria" id="AFZ54798">
        <property type="protein sequence ID" value="AFZ54798"/>
        <property type="gene ID" value="Cyan10605_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2726"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2892"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_3"/>
    <dbReference type="OMA" id="HIAWLGK"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="41485" checksum="4165E2D6BBAA3171" modified="2013-03-06" version="1">MHIAWLGKKTPFCGNVTYSREITTSLVKRGYKVSFLHFSQDNDDSEQDHYSTEVSLPFLYKSQIYTIPAPKSSKILLRSLRELQPDLVHASLTLSPLDFTLPEICQKLNIPLVATFHPPFDSRLRNLKSSTQYLTYQLYAPCLAKYDQTIIFSELQRDLLVKLGVPREKLAIIPNGVDTQKYSPGKSYFKQQHPNDLLYVYQGRIAVEKNVESLLRAWKHSGISQQGKLLIIGDGPLTPNLKPLYNQDDNVIWLGAIVDEEKRIDILRGADVFILPSLVEGLSLSLLEGMSCGLACVATDAGADGEVLANAGIVISTQDVTTQLKTILPLFSHHPEINYLLGEKARKRVLEKYTLSDNVTKLEHLYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z947</accession>
    <name>K9Z947_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220960.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3193"/>
    <dbReference type="EnsemblBacteria" id="AFZ55242">
        <property type="protein sequence ID" value="AFZ55242"/>
        <property type="gene ID" value="Cyan10605_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3193"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3404"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_3"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28637" checksum="43AC543A49AEAD8F" modified="2013-03-06" version="1">MEALVSIVIPVVIFALTGFKVDREYERGVIFRLGRMSGIKGPGIYWTIPLIDQKAKIDIRTKTVDIQSQETITADSVTVRVNAVLYYRVLDPDRAINRIENYEFAVYQASMTTLRNVVGQNILDDILRNRDKINHQIQEIVDEITDPWGIVIERVEMKDVEIPQSMQRAMAQEAEAIREKRARLIKASAEKEASLMLSEASNQIAENPIALELRRLQTLTEIGTENNTTTVMLVPTELITMTKQMAEKMSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z985</accession>
    <name>K9Z985_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221005.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3241"/>
    <dbReference type="EnsemblBacteria" id="AFZ55287">
        <property type="protein sequence ID" value="AFZ55287"/>
        <property type="gene ID" value="Cyan10605_3241"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3241"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3455"/>
    <dbReference type="eggNOG" id="ENOG5032S1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091313_0_0_3"/>
    <dbReference type="OMA" id="AACDQGI"/>
    <dbReference type="OrthoDB" id="1524864at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="225" mass="25001" checksum="D0F1048B0021263D" modified="2013-03-06" version="1" precursor="true">MNNFINARFLKATPILIKGSLTIFIAVGTFSAWQTTRNLWRNFTGMFNYQVTSPTIKDPHILIQQIQGVSELTTTVFVMDAIAPISSQRKLGEWVIGETSLLYIARGEVKAGLDLSKITSEDVSINQDTITIELPAPEILDSKIDVTKSQVYDYDRGFLNLGPDNAPQLQSEAQKQTLNKIKQTACDENILEQANERAIVVISQLMETSGYKNVVVKTSSLETCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R9</accession>
    <name>K9Z9R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221185.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3427"/>
    <dbReference type="EnsemblBacteria" id="AFZ55467">
        <property type="protein sequence ID" value="AFZ55467"/>
        <property type="gene ID" value="Cyan10605_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3427"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3652"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002390_0_0_3"/>
    <dbReference type="OMA" id="CTEVPRR"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="1563"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1815" mass="208339" checksum="929D121D522791D6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA95</accession>
    <name>K9ZA95_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221006.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3242"/>
    <dbReference type="EnsemblBacteria" id="AFZ55288">
        <property type="protein sequence ID" value="AFZ55288"/>
        <property type="gene ID" value="Cyan10605_3242"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3242"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3456"/>
    <dbReference type="eggNOG" id="COG3839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_3"/>
    <dbReference type="OMA" id="HRIAVLN"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="404" mass="45780" checksum="6E27745F96FC2178" modified="2013-03-06" version="1">MSRVTIENLYKTYNSAKEVDESQIITNAVLKGINLQIQEGEFMVLVGPSGCGKSTLLRLIAGLEEISGGKIYIGDRIVNELPPKARDIAMVFQNYALYPHLSVYDNIAFGLRRMKNNDYPSNSPIETLLSSLTGFLPPSLRYVNSTEKKIQAQVKTVAEMLQIDHLLFRLPKQLSGGQKQRVALGRAIARNPQVFLMDEPLSNLDAKLRTETRMQIVKLQKQLQVTTIYVTHDQTEAMTMGDRIAVMNQGEIQQIATPLEIYQHPANTFVAQFIGSPAMNLLEVNYQKPDLLIYGQTKIPLTSQWQEILKDYNYEKIWLGIRPELFYVTEESSASIPVIVNLVEALGHETILTVNAENNPEQNLQIKLFNHDLITFGEKINLGIQLENVNFFDHYTRQNILLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD7</accession>
    <name>K9ZAD7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="10" type="ordered locus">Cyan10605_3522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
            <plasmid evidence="11">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221272.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3522"/>
    <dbReference type="EnsemblBacteria" id="AFZ55555">
        <property type="protein sequence ID" value="AFZ55555"/>
        <property type="gene ID" value="Cyan10605_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3522"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_3"/>
    <dbReference type="OMA" id="AYKLIKH"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="38680" checksum="3EDC2E05764CCA7B" modified="2013-03-06" version="1">MKTVYISQQGCYLCLEKELILVKKNKDIINQIQLPLVEQILIFGKSQLTTQLIRSCLWRDIPILYLSRMGYCYGRIIAIERGYRQLSRYQQQLEFYDQLIVARNIVSAKIKNSKTILQRQQRRKENLELQQTIDSLNYLCQQAEKADSIEKLFGYEGASAASYFSAFGQCFNNPSFIFYSRSRRPPGNQVNALLSFGYQVLWNHLFALIELQGLDPYYGCLHQSSDRHAALTSDLIEEFRAGIVDSLILYLVNKNIINAEEDFVFRNGGCYLNDNGRRKYLQAFVTRMEEMITNEQGYKEPRWDLLMQQVKKIKQFFYSPANTYEPYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZB18</accession>
    <name>K9ZB18_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221288.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3540"/>
    <dbReference type="EnsemblBacteria" id="AFZ55573">
        <property type="protein sequence ID" value="AFZ55573"/>
        <property type="gene ID" value="Cyan10605_3540"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3540"/>
    <dbReference type="eggNOG" id="ENOG50337FE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044780_0_0_3"/>
    <dbReference type="OMA" id="SKRVVIC"/>
    <dbReference type="OrthoDB" id="2018212at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="14045" checksum="ECC5E25B5B22A75A" modified="2013-03-06" version="1">MNKITFAGIKGEVIEQSEHGNYLLVKLSNRISIVGTFSNQFHWQEIHESESGFKSFITYIGFNSDRIQQKYLELINEMGGYVRENEEKRAKMRVKGKFRYEMKVRNLNADHVLDLIATQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZB29</accession>
    <name>K9ZB29_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3550"/>
    <dbReference type="EnsemblBacteria" id="AFZ55583">
        <property type="protein sequence ID" value="AFZ55583"/>
        <property type="gene ID" value="Cyan10605_3550"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3550"/>
    <dbReference type="HOGENOM" id="CLU_1988931_0_0_3"/>
    <dbReference type="OrthoDB" id="1829399at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14891" checksum="29A17B4B64D8C5FB" modified="2013-03-06" version="1">MILIFNKLEGKLMNKPNDVIKTMITQFCGTIDRLVIMLGTKKVIYDNATAMIKFDFKMCHKATLCSIRYDYGMDTYEMEFYKFNRKGMEWETVKTFDDVYCDQLTEIFEDFTGLILNYRPEFISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ85</accession>
    <name>K9YZ85_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ordered locus">Cyan10605_0087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217978.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0087"/>
    <dbReference type="EnsemblBacteria" id="AFZ52246">
        <property type="protein sequence ID" value="AFZ52246"/>
        <property type="gene ID" value="Cyan10605_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0087"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.89"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_3"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="158" mass="17130" checksum="A20C0F9C1F62E2D4" modified="2013-03-06" version="1">MIRIGNGYDLHRLVEGRKLILGGVEIDHHLGLLGHSDADVLTHAIMDALLGALSLGDIGHYFPPSDPKWAGADSMELLYQVDKLIKDKGWSIGNIDSVIVAERPKLKPHLPAMIKSLADKIAIAPEQISIKATTNEKLGPVGREEAICAYAVVLLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ93</accession>
    <name>K9YZ93_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217988.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0097"/>
    <dbReference type="EnsemblBacteria" id="AFZ52256">
        <property type="protein sequence ID" value="AFZ52256"/>
        <property type="gene ID" value="Cyan10605_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0097"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.100"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_3"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="27945" checksum="B359AB89605DD6C9" modified="2013-03-06" version="1">MLDLTGKNALVTGIANNKSIAWGIAQQLHKAGANIGVTYLPDEKGRFEKKVGDLVEPLNPSVFLPCNVQDDAQIDSTFDQIKDQWGHIDILIHCLAFAQKEDLSGEFSNTSRNGFQTALDVSAYSLTRLVQSAKPLFREGSSILTLSYLGGVKVIPNYNVMGVAKSALEMSVRYLASELGPMNVRVNAISAGPIRTLASSAVGGILDMIHHVEKVAPLRRTVTQTEVGNTAAFLCSDLASGITGQIIYVDAGYEIMGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZT7</accession>
    <name>K9YZT7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/proton antiporter, CPA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218161.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0279"/>
    <dbReference type="EnsemblBacteria" id="AFZ52429">
        <property type="protein sequence ID" value="AFZ52429"/>
        <property type="gene ID" value="Cyan10605_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0279"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.289"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_1_3"/>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="525" mass="58104" checksum="20CCE7A262FFD701" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z075</accession>
    <name>K9Z075_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218300.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0425"/>
    <dbReference type="EnsemblBacteria" id="AFZ52569">
        <property type="protein sequence ID" value="AFZ52569"/>
        <property type="gene ID" value="Cyan10605_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0425"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.448"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302429_0_0_3"/>
    <dbReference type="OMA" id="NSATHEW"/>
    <dbReference type="OrthoDB" id="122182at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="6">
        <location>
            <begin position="347"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="616"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="986" mass="115190" checksum="7B6950A7945D38A7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B1</accession>
    <name>K9Z0B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, sigma 70 subunit, RpoD subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218367.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0494"/>
    <dbReference type="EnsemblBacteria" id="AFZ52636">
        <property type="protein sequence ID" value="AFZ52636"/>
        <property type="gene ID" value="Cyan10605_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0494"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.523"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_3"/>
    <dbReference type="OMA" id="AFFKEMA"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017848">
        <property type="entry name" value="RNA_pol_sigma_RpoD_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02997">
        <property type="entry name" value="Sig70-cyanoRpoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="363" mass="42210" checksum="3C259BA63E53ED56" modified="2013-03-06" version="1">MNRTSSTVDYQNGLVNEPLDEDLHQVIAHFSVIEDDSGTKSRRQKTKIEDSIGSFFKEMARYPLLSAEEEVNLAYAVKFLSDCEEKQQELHRQLERTPSKMELAKAMGLESERQLDNRLYKGRTAKRKMIRSNLRLVVSIAKRYLNRGVPFLDLIQEGAIGLNRAAEKFDPNKGYKFSTYAYWWIRQAITRTIANDSRTIRLPIHIVEKLNKLKKAQRILKQDLQRQPTEKELAEEMGITRQALHQLLQLKRQSLSLNHRVGKGEDTELMELLEDTNLLLPEDKMNEAMMHQEIVSVLSDVLSEREKEVIVLRYGLASSKAHTLEEVGKIFDLSRERVRQIQTKAMRKLRRPQVARRLKGWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0G6</accession>
    <name>K9Z0G6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217934.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0041"/>
    <dbReference type="EnsemblBacteria" id="AFZ52202">
        <property type="protein sequence ID" value="AFZ52202"/>
        <property type="gene ID" value="Cyan10605_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0041"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.43"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362043_0_0_3"/>
    <dbReference type="OMA" id="PADPIYF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="344"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="733" mass="83971" checksum="0B54CE0F2708F90E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0K1</accession>
    <name>K9Z0K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217979.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0088"/>
    <dbReference type="REBASE" id="58414">
        <property type="entry name" value="M.Cap10605ORF88P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52247">
        <property type="protein sequence ID" value="AFZ52247"/>
        <property type="gene ID" value="Cyan10605_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0088"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.90"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_0_0_3"/>
    <dbReference type="OMA" id="MNRHGFN"/>
    <dbReference type="OrthoDB" id="1206955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000398-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="35412" checksum="A975AEE097094856" modified="2013-03-06" version="1">MNKPKAKPFLKWAGGKTQLLEIITSNFPYKNQDEFIYVEPFVGSGAVLFWVLNNYQNIKKAIINDINLDLINAYKIIKKNVEDLIFILEKWQNEYYSLEHDQEDKKKYFYEKRDLFNQRKSNQIKHTALFIFLNKTCFNGLYRVNKNNLFNVPIGSYRKPIICDKNNLRLVSNSLKKVEIIHGDFEKTLRYAENKSLFYLDPPYKPLNKTSNFNSYADQKFNDTEQIRLKKFCDKLDQLGCKWILSNSDVREANSENIFFDDLYKKYQIHRVLARRNINSNGLKRGLLNELLITNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P0</accession>
    <name>K9Z0P0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trmFO</name>
        <name evidence="12" type="ordered locus">Cyan10605_0617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218487.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0617"/>
    <dbReference type="EnsemblBacteria" id="AFZ52756">
        <property type="protein sequence ID" value="AFZ52756"/>
        <property type="gene ID" value="Cyan10605_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0617"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.651"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_3"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="5"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="467" mass="51695" checksum="86E2F0488F4E7C3F" modified="2013-03-06" version="1">MTNTNVIVIGGGLAGTEATWQIAQAGVPVTLYEMRPVKNSPAHHSSELAELVCSNSFGADAVDRAAGLLHEELRRLNSIIIQTADEHKVPAGGALAVDRGVFSSNLTQTLANHPLITLERSEIKEIPGDSIVVLATGPLTSDSLAQQLQDLTGMDYLNFFDAASPIIVGESINRDIAFLASRYDKGEAAYLNCPMDKEQYLHFWQELCNAEQAELKDFERESANFFEGCLPIEELAQRGEDTMRYGPLKPIGLFDSRLGDFKAPENKDKRPYAVVQLRQEDKAGQLWNMVGFQTNLRWGEQKRVFRLIPGLENAEFVRMGVMHKNTFLNAPQLLKPTLQFKYRDTLLAAGQLIGTEGYTAAAAGGWLAGTNAARIALNQCPITLPNVTMMGALMDFISTADAKHFQPMPPNFGILPNLPQKIRNKRERYQAYAHRSLDAIAQHNFVNADRVFYGKSLMIGVRSSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q5</accession>
    <name>K9Z0Q5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Protoporphyrinogen IX oxidase</fullName>
            <shortName evidence="15">PPO</shortName>
            <ecNumber evidence="15">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_0595</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:62000"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the HemJ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218465.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0595"/>
    <dbReference type="EnsemblBacteria" id="AFZ52734">
        <property type="protein sequence ID" value="AFZ52734"/>
        <property type="gene ID" value="Cyan10605_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0595"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.627"/>
    <dbReference type="eggNOG" id="COG1981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125006_0_0_3"/>
    <dbReference type="OMA" id="VRLFIYH"/>
    <dbReference type="OrthoDB" id="1433260at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070818">
        <property type="term" value="F:protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02239">
        <property type="entry name" value="HemJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005265">
        <property type="entry name" value="HemJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40255">
        <property type="entry name" value="PTHR40255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03653">
        <property type="entry name" value="UPF0093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00701">
        <property type="entry name" value="TIGR00701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="191" mass="22163" checksum="6D36B631877EBE00" modified="2013-03-06" version="1" precursor="true">MAYYWFKAFHIIGIVVWFAGLFYLVRLFVYHAEAQEKPEPAQSILKKQYELMEKRLYNIITTPGMVVTVAMAIGLISTEPEILKSGWLHIKLLFVALLLIYHFWCGRIMKQLEKGENNWNGQKFRALNEAPTLLLVVIVLLAIFKNNLPLDITTWLIVGLVVFMAASIQYYAKIRRQNEEKLNQSENLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z4</accession>
    <name>K9Z0Z4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen-fixing NifU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218565.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0698"/>
    <dbReference type="EnsemblBacteria" id="AFZ52834">
        <property type="protein sequence ID" value="AFZ52834"/>
        <property type="gene ID" value="Cyan10605_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0698"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_4_3_3"/>
    <dbReference type="OMA" id="CSVNQMT"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="8646" checksum="20E9556A08120B63" modified="2013-03-06" version="1">MSLALTPENVEQVLDELRPYLMADGGNVELVEIDGPTVKLRLQGACGSCPSSTMTLRMGIERRLREYIPEIAEVEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z150</accession>
    <name>K9Z150_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_0798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218662.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0798"/>
    <dbReference type="EnsemblBacteria" id="AFZ52931">
        <property type="protein sequence ID" value="AFZ52931"/>
        <property type="gene ID" value="Cyan10605_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0798"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.840"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_3"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="9"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="416" mass="43447" checksum="1C0C4F04EFD38BB8" modified="2013-03-06" version="1">MTNLQLKRVVVTGLGAITPIGNNLDEYWQGLITAKNGIGKITCFDTSDYACKIAGEVKGFDPLAYMEKKEAKRMARFSQFAVAASKMALEDAQLTINDDNANDVGIVIGTGVGGLSVMEEQNEVLLTKGPGRVTPFLVPTMISNMAAGLTAIHTGAKGPNSCSVTACAAGSNSIGDAFRLVQSGYAKAMICGGTEAAITRLAMAGFASAKALSTRNDSPESASRPFDADRDGFVMGEGCGILILEERESAIARGARIYAEMVGYGMTCDAYHMTAPVPEGLGATRAIELALKDGGLAPDQVSYINAHGTSTPANDTTETKAIKRALGDHAYKIAISSTKSMTGHLLGGSGGIEAVATVMAIASDIVPPTINLQNPDPDCDLDYVPHESRKLTVDVALSNSFGFGGHNVTLAFKKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z192</accession>
    <name>K9Z192_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218233.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0356"/>
    <dbReference type="EnsemblBacteria" id="AFZ52502">
        <property type="protein sequence ID" value="AFZ52502"/>
        <property type="gene ID" value="Cyan10605_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0356"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.374"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364022_0_0_3"/>
    <dbReference type="OMA" id="WLQTEVF"/>
    <dbReference type="OrthoDB" id="230023at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044685">
        <property type="entry name" value="ARC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025344">
        <property type="entry name" value="ARC6-like_IMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33925">
        <property type="entry name" value="PTHR33925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13355">
        <property type="entry name" value="ARC6-like_IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="715" mass="81498" checksum="3F93852E63020B93" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E6</accession>
    <name>K9Z1E6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218720.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0857"/>
    <dbReference type="EnsemblBacteria" id="AFZ52989">
        <property type="protein sequence ID" value="AFZ52989"/>
        <property type="gene ID" value="Cyan10605_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0857"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.900"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291847_0_0_3"/>
    <dbReference type="OMA" id="IERRIIY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="177"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="489"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="570"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="651"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="709"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="896"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1115" mass="129125" checksum="BA9D70EDB025CD25" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I2</accession>
    <name>K9Z1I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218323.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0450"/>
    <dbReference type="EnsemblBacteria" id="AFZ52592">
        <property type="protein sequence ID" value="AFZ52592"/>
        <property type="gene ID" value="Cyan10605_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0450"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_5_3_3"/>
    <dbReference type="OMA" id="IVNCEAN"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15138" checksum="7970B2EB00BD23ED" modified="2013-03-06" version="1">MSNFIYSRKIHFADTDSAGVVYFSNLLSICHEAYEEVLLSLGINLSNFFTDKQLAIPIIHAEIDFFKPLFCGDLINIQCQVNPISDKVFDVNYLVEKDKNLIAKAVTRHICINPETRESQFIPSYLKTLFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1I8</accession>
    <name>K9Z1I8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-carboxy-1,4-naphthoquinone phytyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">1,4-dihydroxy-2-naphthoate phytyltransferase</fullName>
            <shortName evidence="5">DHNA phytyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">menA</name>
        <name evidence="6" type="ordered locus">Cyan10605_0455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4-naphthoquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:31087"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:75434"/>
            <dbReference type="ChEBI" id="CHEBI:87842"/>
            <dbReference type="EC" id="2.5.1.130"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; phylloquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MenA family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.130" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218328.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0455"/>
    <dbReference type="EnsemblBacteria" id="AFZ52597">
        <property type="protein sequence ID" value="AFZ52597"/>
        <property type="gene ID" value="Cyan10605_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0455"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.481"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_2_0_3"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="UniPathway" id="UPA00995"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01938">
        <property type="entry name" value="MenA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011937">
        <property type="entry name" value="DHNA_phytyltransferase_MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02235">
        <property type="entry name" value="menA_cyano-plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="34144" checksum="21C5C620723C0511" modified="2013-03-06" version="1">MSVAEEKIKPIVEEIPSKGKLWYAAIKPPMYTVAVIPICFGTALAYGETGIFNPLIFVTFLFSAILIIAWLNLSNDFFDSYTGIDVNKAHSVVNLTGNAPLIFWISNICLALGLMGIIMINLWLGDWTVMGLIFACCFLGYTYQGPPFRFGYLGLGEIICFITFGPMAIASAYYSQAQNFSVSSLWASVLIGISTSIILFCSHFHQVEDDIKAGKKSPIVRLGTANGAKVLTTSTLVFYGLCILFTFLHLLPYSSLIVFLSLPPAIKMINHVHENHDRPSLVQNSKFIAVKYHFFSGLLLSVSLILNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J2</accession>
    <name>K9Z1J2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mg-protoporphyrin IX chelatase</fullName>
            <ecNumber evidence="6">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60492"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.6.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218333.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0460"/>
    <dbReference type="EnsemblBacteria" id="AFZ52602">
        <property type="protein sequence ID" value="AFZ52602"/>
        <property type="gene ID" value="Cyan10605_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0460"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.486"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_0_2_3"/>
    <dbReference type="OMA" id="RISAVCG"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011775">
        <property type="entry name" value="Mg_chelatase_ATPase-isu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02030">
        <property type="entry name" value="BchI-ChlI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="39895" checksum="D35E8C632B21F88A" modified="2013-03-06" version="1">MTATLEAPPKNRRLVFPFTAIVGQEQMKLALLLNVIDPKIGGVMIMGDRGTGKSTTIRALADLLPEIEVAENDPYNSSATDFELMGDEVKEKIQNGEQVAIARKKVPMVDLPLGATEDRVCGTIDIEKALSEGVKAFEPGLLAKANRGILYVDEVNLLDDHLVDVLLDSAASGWNTVEREGISIRHPARFVLVGSGNPEEGELRPQLLDRFGMHAEIRTVKEPDLRVQIVEQRAEFDRNPQEFMAKYKEKQEELQRKLVDAQNLLPQVTIDYDIRVKISEICSELDVDGLRGDIVTNRAAKAIAAFESRTEVTVDDIRRVMPLCLRHRLRKDPLETIDSGYKVEKSINRVFGLEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N8</accession>
    <name>K9Z1N8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="5" type="ordered locus">Cyan10605_0992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218852.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0992"/>
    <dbReference type="EnsemblBacteria" id="AFZ53121">
        <property type="protein sequence ID" value="AFZ53121"/>
        <property type="gene ID" value="Cyan10605_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0992"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1049"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_1_3"/>
    <dbReference type="OMA" id="YLNQKGR"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="153" mass="17235" checksum="C763761B1B9B9BA8" modified="2013-03-06" version="1">MTHPLIPSILELAEPLAQKLNLEIANIVFQTNKNPPVLRIDIKSVGGDTSLDDCEKMSRQLEEILDVENTLPSTYVLEISSPGIGNNLESDREFVSFKGFPVIVETNTIFKKKNRWEGTLQGRDDQFVYVNCKGKITKIPRDIIQSVQLHNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P5</accession>
    <name>K9Z1P5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Processing peptidase</fullName>
            <ecNumber evidence="6">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218010.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0120"/>
    <dbReference type="EnsemblBacteria" id="AFZ52278">
        <property type="protein sequence ID" value="AFZ52278"/>
        <property type="gene ID" value="Cyan10605_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0120"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.123"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_2_3"/>
    <dbReference type="OMA" id="YDVGSRH"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="266"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="515" mass="58889" checksum="226D9C531C2A888D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U8</accession>
    <name>K9Z1U8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="6" type="synonym">rpl11</name>
        <name evidence="11" type="ordered locus">Cyan10605_0197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218085.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0197"/>
    <dbReference type="EnsemblBacteria" id="AFZ52353">
        <property type="protein sequence ID" value="AFZ52353"/>
        <property type="gene ID" value="Cyan10605_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0197"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.207"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_2_3"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="14937" checksum="3ED37763F7225D6F" modified="2013-03-06" version="1">MAKKVVALIKLALPAGKANPAPPVGPALGQHGVNIMAFCKEYNAKTSNQPGMIIPVEISVFEDRSFTFILKTPPASVLIKKAAGIEKGSKEPNRAKVAQITKAQLEEIAQTKMQDLNANDIDAAMKIIAGTARNMGVTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z219</accession>
    <name>K9Z219_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0628"/>
    <dbReference type="EnsemblBacteria" id="AFZ52767">
        <property type="protein sequence ID" value="AFZ52767"/>
        <property type="gene ID" value="Cyan10605_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0628"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.662"/>
    <dbReference type="eggNOG" id="ENOG5032SKQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169008_0_0_3"/>
    <dbReference type="OMA" id="HEGEWLG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12511" checksum="24CD1527089D57F2" modified="2013-03-06" version="1">MSKWQKKAREFHTLIAPIVLLPLFITMLTGVVYRLGKSWFGLSRDQVHFLMVIHEGEYLGEFLEPIYVLLNGLGLLWMLLTGLLILINSWQRNPLFKKLFHKQANSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z225</accession>
    <name>K9Z225_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1119"/>
    <dbReference type="EnsemblBacteria" id="AFZ53241">
        <property type="protein sequence ID" value="AFZ53241"/>
        <property type="gene ID" value="Cyan10605_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1119"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513610_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="530" mass="60731" checksum="10561F5EA9DA3477" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z257</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0331</name>
    </gene>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0331"/>
    <dbReference type="EnsemblBacteria" id="AFZ52478">
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        <property type="gene ID" value="Cyan10605_0331"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="30674" checksum="CFFAACEBEB875D8E" modified="2013-03-06" version="1">MINHLLNNKKQWFNVIDIIAIFSWSILLFKYWITGQLYLLIHPNYFLLVLISSIILLLLSIAKIYQVFIYHQKNPNFEQLANSQHSNLLPKGWGSSLLIAVAVLGLIINPMVLNSQTAMQRGVTDTLPPTTLQTQSFLNQIPPEKRSLIEWVRTLNVYPEPDNYIGQSANITGFVVHLDHLPDNYIYLSRFVLTCCAVDAYPVGILVELPDSRNEFPPDSWLEVQGLMNTVTLPALEVTENKLVKEKRQLVLQAKMVKTIPTPSNPYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E5</accession>
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        <submittedName>
            <fullName evidence="6">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1260"/>
    <dbReference type="EnsemblBacteria" id="AFZ53376">
        <property type="protein sequence ID" value="AFZ53376"/>
        <property type="gene ID" value="Cyan10605_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1260"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_2_2_3"/>
    <dbReference type="OMA" id="FIKCMRN"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15946" checksum="4365191B94F0740C" modified="2013-03-06" version="1">MLNSFTIGNVAKQSNLPVKTVRYYADLGLLSPHLSRDNNGYRLFSPAVFQRLNFIRRSQSLGLTLKEIKQILVVYDQQQIPCSVAKQLLTDKLEEIESKINELKMLKDELNGILSSWQEIKNFENVKDNICPNIANINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K5</accession>
    <name>K9Z2K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0830"/>
    <dbReference type="EnsemblBacteria" id="AFZ52962">
        <property type="protein sequence ID" value="AFZ52962"/>
        <property type="gene ID" value="Cyan10605_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0830"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.873"/>
    <dbReference type="HOGENOM" id="CLU_2568119_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9291" checksum="D57391C66B28F70D" modified="2013-03-06" version="1">MLVKKYLLKISDKGGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLKEQELKVTLNKCEEIGRMLHSLIEKLSQNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y7</accession>
    <name>K9Z2Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0818"/>
    <dbReference type="EnsemblBacteria" id="AFZ52950">
        <property type="protein sequence ID" value="AFZ52950"/>
        <property type="gene ID" value="Cyan10605_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0818"/>
    <dbReference type="eggNOG" id="ENOG503383T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2463899_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="88" mass="10345" checksum="895FDDE554C23DBA" modified="2013-03-06" version="1">MGYNEWANSQGIILSEMKTITLRIDDRIKEQFISLLKNFSENELRILEESEYISDDEYLRSLSGMVESIKEARKEPIENGVTLEELDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z396</accession>
    <name>K9Z396_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218796.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0935"/>
    <dbReference type="EnsemblBacteria" id="AFZ53065">
        <property type="protein sequence ID" value="AFZ53065"/>
        <property type="gene ID" value="Cyan10605_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0935"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.984"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_3"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="30"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="419" mass="46674" checksum="54B6B34713AEAE01" modified="2013-03-06" version="1">MTLTYKKTIADEVRQDFPILHQKIHDKPLIYFDNAATSQKPRAVIEALRHYYEYDNANVHRGAHTLSARATDAYEGARDKIAKFINAKSRNEIVYTRNASEAINLVAYSWGLAHLKAGDEIILSVMEHHSNIVPWQIIAQKTEAILKFVELTPSQEFDFNHYQSLLSEKTKLVSLVHVSNTLGCINPVTEIITSAREKGAKVLIDACQSLPHLPIDVQGMDCDWLVGSGHKMCATTGIGFLYGKEELLEAMPPFLGGGEMIADVFLDHFTCGELPHKFEAGTPAIGEAIAFGTAIDYLSNIGMENIHQYEEELTAYLFQQLNEIPNLTIYGNQPTTEGKGRAALAAFNVKDIHGSDLSTLLDHEGIAIRSGHHCTQPLHRYLNISGSARASLYFYNTFAEIDAFIVALKETIDFFTQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D7</accession>
    <name>K9Z3D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA modification methyltransferase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219423.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1588"/>
    <dbReference type="REBASE" id="58406">
        <property type="entry name" value="Cap10605ORF1588P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53696">
        <property type="protein sequence ID" value="AFZ53696"/>
        <property type="gene ID" value="Cyan10605_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1588"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1687"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005831_1_1_3"/>
    <dbReference type="OMA" id="HKLGAHY"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="381"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="921" mass="105717" checksum="B7F09897F0FD26FA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3F2</accession>
    <name>K9Z3F2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.12</ecNumber>
            <ecNumber evidence="2">5.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.12" evidence="2"/>
    <dbReference type="EC" id="5.1.3.6" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218986.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1135"/>
    <dbReference type="EnsemblBacteria" id="AFZ53257">
        <property type="protein sequence ID" value="AFZ53257"/>
        <property type="gene ID" value="Cyan10605_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1135"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1202"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_3"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050378">
        <property type="term" value="F:UDP-glucuronate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="329" mass="37580" checksum="60C4971E599F9F70" modified="2013-03-06" version="1">METILITGSSGFIGFHLSQRLLNDGYSVIGIDNMNDYYDVSLKQARLEILKQHHNFQFFLLDLVDRISIMNLFKENKITTVVNLAAQAGVRYSLENPHAYVDSNLIGFVNILEACRHHNIQHLVYASSSSVYGANKKIPFSTQDNVDNPVSLYAATKKANELMAHTYSHLYNIPTTGLRFFTVYGTYGRPDMAYFIFTKNILEGKKIKVFNYGDMQRDFTYIDDIIEGVVRVMKQIPTPQTDNPNSKAPYRLYNIGNNKPVKLIDFITTIEKSLGVTAEKEFLPIQPGDVPITYADVDDLYKSVGFKPSTPIEKGIDEFVKWYREFYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G1</accession>
    <name>K9Z3G1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha-L-glutamate ligase</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimK</name>
        <name evidence="10" type="ordered locus">Cyan10605_1001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RimK family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218861.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1001"/>
    <dbReference type="EnsemblBacteria" id="AFZ53130">
        <property type="protein sequence ID" value="AFZ53130"/>
        <property type="gene ID" value="Cyan10605_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1001"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1058"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_0_1_3"/>
    <dbReference type="OMA" id="CYMNIAS"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01552">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023533">
        <property type="entry name" value="RimK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="104"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="301" mass="32902" checksum="900CCB809BBF4A6D" modified="2013-03-06" version="1">MKIAILSQDSSLYSTRRLRDAGEKRGHEIKVVNYLRCYMNITSHKPSVVYGGKELENFDAIIPRIGASRTFYGCAVVRQFEVMGVFSANESQAISRSRDKLRCVQILAREGIGLPVTGFAHDTEDIDGLIETVGGAPLVIKLLEGTQGIGVVLAETYQAAKSVIQAFRGLNANILVQEFIREAGGADIRCFVIGNKVVAAMKRQGAEGEFRSNLHRGGKAEKIKLTPEERSTAIRSAKAMGLRIAGVDLLRSNHGPVVMEVNSSPGLEGIEKATNIDIADKIIEFIEKNVESGNNRDRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J0</accession>
    <name>K9Z3J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218886.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1029"/>
    <dbReference type="EnsemblBacteria" id="AFZ53155">
        <property type="protein sequence ID" value="AFZ53155"/>
        <property type="gene ID" value="Cyan10605_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1029"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479608_0_0_3"/>
    <dbReference type="OMA" id="YHARIQD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="568" mass="63872" checksum="6E23B3CB64C8AB2E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L2</accession>
    <name>K9Z3L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="4">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.60" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1606"/>
    <dbReference type="EnsemblBacteria" id="AFZ53714">
        <property type="protein sequence ID" value="AFZ53714"/>
        <property type="gene ID" value="Cyan10605_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1606"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1705"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_8_3"/>
    <dbReference type="OMA" id="IFVDHTT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="172"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="31973" checksum="C88DCCFBB005CF6C" modified="2013-03-06" version="1">MFAEISSKGESMTKVAVLGMGLMGYPMILRLAQAQIPVIAYNRTQAKLESLKEKNIPVTSNIHEAIAFGDVIILMLSDIGAIQEVIFDSGVDLEGKTIIQMGTIAPGESKGLYVTIQEKGGDYLEAPVLGSIPEVKSGKLLLMVGGDKSLFRAVEELLTHFSPKPLYIGEIGSAAALKLALNQMIAGLTSTFALSLSYIQKQGVEVETFMEILRNSALYAPTFDKKLQRMCDHNFSNPNFPTKHLLKDINLFLASAQTINLNTTTLEGIKEITTLAVENGEADSDYSAIIQAIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3L6</accession>
    <name>K9Z3L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218709.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0846"/>
    <dbReference type="EnsemblBacteria" id="AFZ52978">
        <property type="protein sequence ID" value="AFZ52978"/>
        <property type="gene ID" value="Cyan10605_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0846"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.889"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_2_3"/>
    <dbReference type="OMA" id="WFPMGLI"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="11479" checksum="F0C941FCA8B20159" modified="2013-03-06" version="1">MSLTSLLKEKRAEIIAIAAKHGAFNVRVFGSVATGKEKENSDIDFLIDYDPHKVTSWFPGGLLMDLQDLLGCKVDIVTEDGISHLIRERILKEAKPLAKIQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P9</accession>
    <name>K9Z3P9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9 14">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="9">GluTR</shortName>
            <ecNumber evidence="4 9 14">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemA</name>
        <name evidence="18" type="ordered locus">Cyan10605_0883</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 14">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 14">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 9 14"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218744.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0883"/>
    <dbReference type="EnsemblBacteria" id="AFZ53013">
        <property type="protein sequence ID" value="AFZ53013"/>
        <property type="gene ID" value="Cyan10605_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0883"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.928"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_1_3"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="5 9 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="320"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 12">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="9 13">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="427" mass="47941" checksum="E7B3AB151F96B504" modified="2013-03-06" version="1">MNIVVVGLSHKTAAVEVREKLSIPEAKIEDSIRHLLTYPHIEEVAIISTCNRLEIYAVVKETEQGVKEITQFLAEIGNLALLELRRHLFILLHQDAIRHLMRVAAGLESLVLGEGQILAQVKTTHKLGMKYNGMSRLLDRLFKQAISAGKRVRTETNIGTGAVSISSAAVELVDTKIEDLSSQKVTIIGAGKMSRLLVQHLLAKGVEDIIIVNRSHNRSQELAKQFPQANLKLNLLEDMMTMVAQSDIVFTSTGATQPILDKNNLSSLSINHSLMLVDISVPRNVASDVTELEFIKSYNVDDLKAVVAQNHASRREMAREAENLLEEEIEAFELWWQSLETVPTISCLRSKIEQIREQELEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLRTQKDIEARRKALHTLQTLFDLEVSEQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q2</accession>
    <name>K9Z3Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1653"/>
    <dbReference type="EnsemblBacteria" id="AFZ53759">
        <property type="protein sequence ID" value="AFZ53759"/>
        <property type="gene ID" value="Cyan10605_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1653"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019299_0_0_3"/>
    <dbReference type="OMA" id="TRPCVMS"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="543" mass="62832" checksum="624C6CB224CA2CA0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T1</accession>
    <name>K9Z3T1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pnp</name>
        <name evidence="8" type="ordered locus">Cyan10605_1686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219516.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1686"/>
    <dbReference type="EnsemblBacteria" id="AFZ53789">
        <property type="protein sequence ID" value="AFZ53789"/>
        <property type="gene ID" value="Cyan10605_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1686"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1789"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_3"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="634"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="718" mass="78633" checksum="B4439CFC04AE4386" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U4</accession>
    <name>K9Z3U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218966.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1113"/>
    <dbReference type="EnsemblBacteria" id="AFZ53235">
        <property type="protein sequence ID" value="AFZ53235"/>
        <property type="gene ID" value="Cyan10605_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1113"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1177"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_3"/>
    <dbReference type="OMA" id="TRHGKTE"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="23639" checksum="0BB5EBB55F7F0C04" modified="2013-03-06" version="1">MSLIIYFLRHGETTASTTGGYCGVLDLDLTPEGYLMAEDFAKAYKSIPWQGIFSSPLTRTIATATPLAKTIGMGIQQRDGLREIAYGNWEGKTPDEVNQLYHDEYVRWLADPGWNAPTGGEKGIDIARRSNEVLEEIERNYPTGNVLIVSHKATIRIMLCSLLGIDIGRYRDRISMPVASVTTVTLTDRGPRLDTLCDRTHLRPELHARKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W3</accession>
    <name>K9Z3W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ordered locus">Cyan10605_1789</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1789"/>
    <dbReference type="EnsemblBacteria" id="AFZ53891">
        <property type="protein sequence ID" value="AFZ53891"/>
        <property type="gene ID" value="Cyan10605_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1789"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1897"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_3"/>
    <dbReference type="OMA" id="ERSCFHQ"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ53891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="232" mass="26440" checksum="B7FB1EB2F37EC795" modified="2013-03-06" version="1">MMIKTQSYLIVTSNPQMSINPSIPLSQSIPVDKIQYNEQGLVPAITQDYLDGTVLMMAWMNKESLRKTLETGEAWYWSRSRQELWHKGATSGHIQKVKTIRYDCDSDALLLTIEQVGDVACHTGERSCFHQIDHSKSAPSADTLTELFKIICDRKEHPVEGSYTCKLYEGGDNKILKKIGEESAEVVMACKDNDPDEIVAEVADLFYHTLVALAYHKVNLRDVYKKLQERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z421</accession>
    <name>K9Z421_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219221.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1379"/>
    <dbReference type="EnsemblBacteria" id="AFZ53492">
        <property type="protein sequence ID" value="AFZ53492"/>
        <property type="gene ID" value="Cyan10605_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1379"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1457"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_3"/>
    <dbReference type="OMA" id="GNPHLHF"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="39018" checksum="9030D44F169B32A7" modified="2013-03-06" version="1" precursor="true">MKRISYPILKLFLILTIFNLVACNQEKISRSTQENTTEINQNQTENRQEKLNITVTIPPQKYFVEKIGGELVNVNVMIGPRLEPHTYEPQPQQLTSLAESSAYVAIGVPFEEVWLNKITTANPQIVMINSGEGINKIPLVGHDHDHNHENDNHNHEDEHNEDIEHNESNYTSETSSPDPHIWLSPKLAKIQAENIYQGLVKINPENQQIYQENLTKFLTEIDNIDQQIKEKLAPINNRKFFIYHPAWGYFAQEYNLQQIPLEFEGQEVTSQELSNLIKQAKAEKINTVFAQPQFNNKTMEIFAKEIGAEIVLLDDLAQNWSENMLSTADKLAKAMTNNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z442</accession>
    <name>K9Z442_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit might be involved in maturation of a crRNA intermediate to its mature form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219074.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1226"/>
    <dbReference type="EnsemblBacteria" id="AFZ53345">
        <property type="protein sequence ID" value="AFZ53345"/>
        <property type="gene ID" value="Cyan10605_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1226"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1294"/>
    <dbReference type="eggNOG" id="COG1332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036878_3_0_3"/>
    <dbReference type="OMA" id="WCALWLE"/>
    <dbReference type="OrthoDB" id="1989826at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010173">
        <property type="entry name" value="CRISPR-assoc_Csm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38007">
        <property type="entry name" value="PTHR38007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01899">
        <property type="entry name" value="cas_TM1807_csm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="425" mass="49532" checksum="37DEF63C5C1E9AC9" modified="2013-03-06" version="1">MNTTTLQPLTFTKNYQTAKIRLTSPILRIGGAVSQLNPYEYIQAGGKVYLPNQEALARVLLERGKLQQYIQKIEDKEDIKYLLDSIDENWQNLTDSYDNQVFPAIGISRKWVNGKISDLRPMIRNGFGEPYIPGSSIKGAMRSAIAFFLLKHREEYNTPKRISQIEAQLRQKINNGELRRRAKFADDRLFMSDLFEDFSLGYKDKKYQPRIGPYTDFLRALDISDSTPLLAQTVPNKKTGKRKTYNIPVVTEVIVSSHFHDYNAKYKASLYTEMIFNVRCEFTITLDVEMLSWFNHNQGMKLPFNSIEELVNICQEFSQIQWDGEYDYWNNINDNKDKGKNLDFESIRDFYEEEKCPYQLRLGWGTSMGGTTINWLINDDLREQIRDTCGLKAPNFQAPKSRRTILNRDSHIRYVPGWTKLNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z456</accession>
    <name>K9Z456_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ordered locus">Cyan10605_1032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218889.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1032"/>
    <dbReference type="EnsemblBacteria" id="AFZ53158">
        <property type="protein sequence ID" value="AFZ53158"/>
        <property type="gene ID" value="Cyan10605_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1032"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1094"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_3"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="179" mass="20916" checksum="E5B569059DDCD4F8" modified="2013-03-06" version="1">MTYSNKKNNQRDLPKINENIRFPKVRLIDTDGEQLGVLDTRDANRLAEEKELDLVLVSETADPPVCRIMDYGKFKFEQEKKARAIRKKQHTADVKEVKMRYKIDEHDYQVRLNQAKRFLKAGDKVKATINFRGREAQHTHLGQELLERLAEDLGEMAEVQQRPKKEGRNMIMLLSPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z490</accession>
    <name>K9Z490_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminobutyrate aminotransferase apoenzyme</fullName>
            <ecNumber evidence="4">2.6.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219134.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1290"/>
    <dbReference type="EnsemblBacteria" id="AFZ53405">
        <property type="protein sequence ID" value="AFZ53405"/>
        <property type="gene ID" value="Cyan10605_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1290"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1363"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_3"/>
    <dbReference type="OMA" id="ELDQWKP"/>
    <dbReference type="OrthoDB" id="386839at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="463" mass="50240" checksum="9E020D9C3632B11E" modified="2013-03-06" version="1">MQQLCNDLGQMMSSAPHSTTVQMRSLPGNHSRAYLDRQQLRESNARSYPRRIPMAIREAKGIFVTDVDGNVYFDCLAGAGTLALGHNHPAVIEAMQQTLTGNYPLHTLDLTTPIKDRFVEELFASLPENFAKRAKIQFCGPTGADAVEAALKLVKTATGRRSVLSFSGGYHGMSHGALSLTGNIAPKSAVPGLMADVHFLPYPYDYRCPFGVGGDNGHKISSRYIEYLLEDPESGIVPPAGMILEVVQGEGGVIPAPDAWLQEMRRITSERDIPLIVDEIQTGWGRTGNLYAFERSGITPDVLLLSKAIGGSLPLSVVLYDEKLDLWKPGAHAGTFRGNQLAMAAGTATLKYIMENQLVDSVKVLGDRLMQNLQQIQGNHPCIGDVRGRGLMVGVEIVNPHGGKTAYPELARKIQKACLERGLILELGGRFGTVVRFLPPLIITADQIDAISEIFAQAVEAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z495</accession>
    <name>K9Z495_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219296.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1456"/>
    <dbReference type="EnsemblBacteria" id="AFZ53567">
        <property type="protein sequence ID" value="AFZ53567"/>
        <property type="gene ID" value="Cyan10605_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1456"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1544"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119719_0_0_3"/>
    <dbReference type="OMA" id="NQIIQWE"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="17245" checksum="C63C501118C7DCA0" modified="2013-03-06" version="1">MTNWLEHSVQIEVNAPIDLVWSLWSDLEQMPQWMKWIDSVHILADDPDLSRWRLASGGFEFSWLSRIVKLEKNQIIQWESVDGLPNRGAVRFYDRHSNSIVRLTVAYAIPGIIGKLMDNLFLGQVVESTLKADLERFKNYIETKKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B0</accession>
    <name>K9Z4B0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219704.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1879"/>
    <dbReference type="EnsemblBacteria" id="AFZ53979">
        <property type="protein sequence ID" value="AFZ53979"/>
        <property type="gene ID" value="Cyan10605_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1879"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1994"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_3"/>
    <dbReference type="OMA" id="CISRIEA"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13206" checksum="DA852A57867F04C9" modified="2013-03-06" version="1">MRKTDIVRLQHMIDSGKKAISFTLNRQRVDLDQDEMLTLALVRLLEILGEAGKNVSEATKAKSPNIPWRLICGTRDRLIHAYFDINLDIVWEIVNQDLPSLIPQLESLLNEIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D7</accession>
    <name>K9Z4D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver modulated diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219729.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1906"/>
    <dbReference type="EnsemblBacteria" id="AFZ54004">
        <property type="protein sequence ID" value="AFZ54004"/>
        <property type="gene ID" value="Cyan10605_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1906"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2023"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_3"/>
    <dbReference type="OMA" id="CRQMRQW"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="211"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="353"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="611" mass="70163" checksum="41F7E4A55A160175" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E2</accession>
    <name>K9Z4E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS/PAC sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ53238">
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="63"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="522"/>
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        </location>
    </feature>
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            <end position="826"/>
        </location>
    </feature>
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        <location>
            <begin position="855"/>
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    </feature>
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            <position position="904"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="972" mass="109967" checksum="FEFE30BE56B4386F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F0</accession>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="14069" checksum="8A5A2720CABD5FAC" modified="2013-03-06" version="1">MWFFHWEINIAIITGSFLWCLALYLGFAQLREMVIDGLYRWFNFAERFLYTSEAEFERTRKGRESQNAFLASLMSVIPFLILGLLCNWLVEIGLGRNWSISVGILAVICCAVYDLGRRDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="Cyan10605_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1434"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="21227" checksum="10B6F3B7CE0BE255" modified="2013-03-06" version="1">MENRNWQLIDTIVEIKSPWVTLIGERIKDDQDNILDYWRVEKEDSVIVVTRYKNSLIFPKSTFRPGIKKVTIDFAGGRLKKNNNLENTAYKILQRELNLTQDKVKIITPINQQGFIINSSFSNQKLWGFYCELKSDISLDNLFIGAIYSLNSNDFKRLLNDLQCLQCRSLLLECVSQGLVATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P6</accession>
    <name>K9Z4P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219102.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1257"/>
    <dbReference type="EnsemblBacteria" id="AFZ53373">
        <property type="protein sequence ID" value="AFZ53373"/>
        <property type="gene ID" value="Cyan10605_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1257"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100519_1_0_3"/>
    <dbReference type="OrthoDB" id="1928373at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="24714" checksum="F0E6328DBE242A7F" modified="2013-03-06" version="1">MENNQLKYHQLKNKLIGEILQEAGFVNSDQVAVALMEQSFYTHLKLGEILALHGWVNQELVDFFAERIQLPPKKEAKKIGEYLLEAGLLTEKDIQEILKEQHKSGVKFGSLAVLRGCIKQETLNFFLKYFTNEGLNDNHLQYKIRTLSKQSKFTNSHKNTTHNDMEKEKSFVTSSNNHRDKQSLNSKHTKNIIDNQELVEDDLESMTWLKTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z551</accession>
    <name>K9Z551_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ordered locus">Cyan10605_1770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219599.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1770"/>
    <dbReference type="EnsemblBacteria" id="AFZ53872">
        <property type="protein sequence ID" value="AFZ53872"/>
        <property type="gene ID" value="Cyan10605_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1770"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1879"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_3"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="36845" checksum="B16B8B661ACE249B" modified="2013-03-06" version="1">MAETRAKIAVDAMGGDNAPQEIVAGAIRASAELDVDILLVGDPEAIQAQLDHHGCTSTNIEIVAADGVVSMEEEALVGVRRKPNASINVAMGLVRENRAQAVVSAGHSGAAMAAALLGLGRLKGIDRPAIGAVFPTMYANKSVIVLDVGANVDSKPKYLEQFALMGTVYSKYVLGVEDPKVGLINIGEESSKGNELAKETYKLLSENPKIPFIGNAEGRDVLSGNFDVIVCDGFVGNVLLKFAEAVGEIMLQIIKEELPYGVRGKIGTGILKPNLRRIKQRIDHAEHGGALLFGVNGVCIISHGSSQAPSIFSAIRIAKEAVDNQVLDRIRNFQGEKSVSNEQLGITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z560</accession>
    <name>K9Z560_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ordered locus">Cyan10605_1780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1780"/>
    <dbReference type="EnsemblBacteria" id="AFZ53882">
        <property type="protein sequence ID" value="AFZ53882"/>
        <property type="gene ID" value="Cyan10605_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1780"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1889"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_1_3"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="29813" checksum="899EA8C9394FA471" modified="2013-03-06" version="1">MMSEADNYPELDKKTDIADHETNSSPSEEINNQELEVMDTDFEQQPVSETVVNDEENAEPSKADTTEPQTENNELNSVVESLQKEIESLKQELELKEEQVKSATSQFMRLTADFDNFRRRTSREKEELESQVKKKIINEILPAVDNFERARSQIKPANEGEMTIHKSYQGVYKILVEGLKKVGVSAMRPENQPFDPNFHEAMLREPTNEYPEGTVIEQLVRGYMIDDQVLRYAMVKVAMPGENESENTDSESETPENSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z599</accession>
    <name>K9Z599_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium/proton antiporter, CPA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219644.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53917">
        <property type="protein sequence ID" value="AFZ53917"/>
        <property type="gene ID" value="Cyan10605_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1815"/>
    <dbReference type="eggNOG" id="COG3263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_9_0_3"/>
    <dbReference type="OMA" id="WFDEYGE"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="44153" checksum="EBD6EF7A5F11F6F0" modified="2013-03-06" version="1">MNLSYLSIEELFLIFGILILASVFASKIASRLGVPALLLFLLIGILSGSQGVGGIDFESYGVSQYVADSALVIILFSGGLDSKWRQIRPIIKEGLLLSTLGVCITAVLVGSFAWLILGSFSSFNLGVNGISWTEGLLLGAIVSSTDAAAVFSILKSSNIRLKNNLQPLLELESGSNDPTAILLATSIIGVLAQGVFNPTVIIFSLLLQILIGSFFGYYGGLLMVWVINRIQLASDGLYPVCAFGLLLMIFSITAFARGNPFLAVYIIGIVFSNSNVLKKELIISFHDGLSWLMEITMFLTLGLLVFPSDLLSNISVGIAIALFLILIARPISVFLCLAPFSKYKQADKLFVSWVGLRGAVPIVLSIMPITQGFEYADQIFNLVFFLVIISVLIQGLSLTPMARFLKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D2</accession>
    <name>K9Z5D2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1659"/>
    <dbReference type="EnsemblBacteria" id="AFZ53765">
        <property type="protein sequence ID" value="AFZ53765"/>
        <property type="gene ID" value="Cyan10605_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1659"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1761"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914700_0_0_3"/>
    <dbReference type="OMA" id="EPLAYAM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="325" mass="36702" checksum="1CE7356AA9B68407" modified="2013-03-06" version="1" precursor="true">MSFVFVNRFSYIHRFFNGLRDKKHLFLWSLVSSGILSSLTVISFASSAFAGDPFRTVNPRNISEETELAFKALFEEGNYVEAKEYLALPKKSSFNDPMSAALRASLAYTEQDWNNLDIYAQKTLDYAKAIRNDDPLRSNLYLAVGNFLMGASEYQSKGAIAAITRLQAVFNYFDQAERIDSTDPELNLIKGYLNLFLAVNLPFSSPQQAIANLQTYASPQYLVNRGIALAYRDLGDYDLALTFVNKALESTPLNPELYYLKGQILRNKGQTDNNILVLEEAVKNFDIAIAKIDQLPLEAVQKPLQREKRKTLETINQLKMVSQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J7</accession>
    <name>K9Z5J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer with GAF sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220185.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2378"/>
    <dbReference type="EnsemblBacteria" id="AFZ54461">
        <property type="protein sequence ID" value="AFZ54461"/>
        <property type="gene ID" value="Cyan10605_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2378"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2525"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_2_3"/>
    <dbReference type="OMA" id="TARNIEY"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="5">
        <location>
            <begin position="460"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="5">
        <location>
            <begin position="632"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="794"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="850"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123732" checksum="CDAEACF9081333FE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N0</accession>
    <name>K9Z5N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219772.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1951"/>
    <dbReference type="EnsemblBacteria" id="AFZ54047">
        <property type="protein sequence ID" value="AFZ54047"/>
        <property type="gene ID" value="Cyan10605_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1951"/>
    <dbReference type="eggNOG" id="ENOG5032RTW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169604_0_0_3"/>
    <dbReference type="OMA" id="DFQYWFS"/>
    <dbReference type="OrthoDB" id="1987856at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019728">
        <property type="entry name" value="DUF2605"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10792">
        <property type="entry name" value="DUF2605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12531" checksum="D8635118BA8B34D2" modified="2013-03-06" version="1">MQPSQPTEKELLRKILLPLLEDFKYWFSRSSSLLESENMPFLSQEEQTGLLNRLKQAQGEVETARMLFNVTDGQAGVDTRVLLPWHQLVAECWDVARRWREVKQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N1</accession>
    <name>K9Z5N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219410.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1574"/>
    <dbReference type="EnsemblBacteria" id="AFZ53683">
        <property type="protein sequence ID" value="AFZ53683"/>
        <property type="gene ID" value="Cyan10605_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1574"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_2_0_3"/>
    <dbReference type="OMA" id="FPWVYYN"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="PTHR10632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="45781" checksum="8103D3A2DBFC5D0F" modified="2013-03-06" version="1" precursor="true">MSKNTKFQILIIGGGAAGITVASQLKNKNSKLNIAIIEPSENHYYQPAWTLVGGGEFQLEDTVKHEDNLIPQGVTWIKDFAENIDPENNQVTTKSGNVFSYEYLVVCPGITIDWDKIKGLRENLGKNGVTTNYMKEYAPYTWETIKNFQGGTAIFTFPAGAIKCPGAPQKIMYLAEEAFTRQGVREKTNIVYGNATGKMFGVPAYNAPLEKIVDRKNINVKYGHNLVEIKGDTKEAIFATGEGETVTIKYDMIHVSPPMTTYDFIKQSPLANEQGWVDVDQFTCQHTKYKNVFGLGDSSSLPTSKTAAAIRKEAPVVVANILALMSQKTPQEKYGGYACCPLITGYGKTIMAEFDYSKQPTPSFPLDPTQERASMWLVKKYILPWLYWNRMLKGKPFEPDSWRFLLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R5</accession>
    <name>K9Z5R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219440.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1605"/>
    <dbReference type="EnsemblBacteria" id="AFZ53713">
        <property type="protein sequence ID" value="AFZ53713"/>
        <property type="gene ID" value="Cyan10605_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1605"/>
    <dbReference type="eggNOG" id="ENOG5030YCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418884_0_0_3"/>
    <dbReference type="OMA" id="PRLMIEG"/>
    <dbReference type="OrthoDB" id="1912796at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="21549" checksum="2D4106527F215CBF" modified="2013-03-06" version="1" precursor="true">MSNKTKILSIGILSFLLSILTVLIVQAQSQLTIESKVSINSIDSIKVGMNLPEAAMATKTKLYLAYAGSDSCYYLQTEGELKDVSFMVTKDEQKSKQKYITSDTIARIDINNPKVTTISGAKIGDSETKIKSIYGDKIKVSAHPYNPKGHYLTFIPQDEEDKNYRLIFETDGKVVTSYRVGKLPEVEYIERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U3</accession>
    <name>K9Z5U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219837.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54112">
        <property type="protein sequence ID" value="AFZ54112"/>
        <property type="gene ID" value="Cyan10605_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2018"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_3_3"/>
    <dbReference type="OMA" id="ANEFRCR"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="13295" checksum="881D75BA22143757" modified="2013-03-06" version="1">MENLDFQIANEFRCRLESITPVVDMRIFGSRARGDAQPDSDLDVFIKVNFLDRSLREMIYDLAWEIGFQHDRIISTFVVTEEQIKYGAVGANPLLSQVMKEKPMITEKCCSLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z1</accession>
    <name>K9Z5Z1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ordered locus">Cyan10605_2525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220329.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2525"/>
    <dbReference type="EnsemblBacteria" id="AFZ54606">
        <property type="protein sequence ID" value="AFZ54606"/>
        <property type="gene ID" value="Cyan10605_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2525"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2679"/>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_2_1_3"/>
    <dbReference type="OMA" id="TQYTRLF"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="25742" checksum="E13DD9CE9B5BF7D9" modified="2013-03-06" version="1" precursor="true">MSNYLLSLLQLCNSSLPLGAYSYSEGLEFLVENGNITNGESLRQWLENELFYGSIRIEGAIAFRAYNCYLNDDCKGLYYWNNWLSASRETKELREQSWQMGKSLCRLTLQLIPDDKKLKSVIDNFDSPCNSAIAFGIISAYSQIPSTEMLWGYLHSWLNNLVNGGVKLIPLGQTEGQKLIFNLHESIINTTQQIINLQDDQLASCSWGLSFASIHHETLYSRLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z603</accession>
    <name>K9Z603_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219892.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2078"/>
    <dbReference type="EnsemblBacteria" id="AFZ54167">
        <property type="protein sequence ID" value="AFZ54167"/>
        <property type="gene ID" value="Cyan10605_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2078"/>
    <dbReference type="eggNOG" id="ENOG5034APW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899310_0_0_3"/>
    <dbReference type="OMA" id="ITHDEME"/>
    <dbReference type="OrthoDB" id="2151943at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="35774" checksum="282D5B54762D2CBE" modified="2013-03-06" version="1">MKNYEKMKELIKENKLQEALLLAFSNSLKLKITTKSKGKKEDVIETLINLVRGISNKVSDPDLINNSTSNNPDTINIVDFHERQRQLAYETWHKNRETLIGILQIISGNSTSINKFKKSENNVISIKGKTEQKETDFQDFDFAQEELDNHQPQEEEGNWLDNIVDSIVGGEEDEMSHTENSEQNWGDFITEDEEEESAEVIINSEEENWDEFIDNDYSEDSIANSNGANIDKSSDGGEWQEWLEEDSVSSENEEVINNAVTDNPSNLEVGEEWQEWLENEDNSDDEIITHDEMEEIDWNDEDWQEEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z618</accession>
    <name>K9Z618_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1924"/>
    <dbReference type="EnsemblBacteria" id="AFZ54020">
        <property type="protein sequence ID" value="AFZ54020"/>
        <property type="gene ID" value="Cyan10605_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1924"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2045"/>
    <dbReference type="eggNOG" id="ENOG5032S35">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186123_0_0_3"/>
    <dbReference type="OMA" id="ECELEKC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025477">
        <property type="entry name" value="DUF4327"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14217">
        <property type="entry name" value="DUF4327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="9223" checksum="60AFB4D19E1EEF0F" modified="2013-03-06" version="1">MMKTLTKNATDYSIEMIRDEARHLVEKGVVSRHQPIYILCQYIPAREWVCVECELEQCDYLLRDQIGDLIACENWESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z643</accession>
    <name>K9Z643_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SOS-response transcriptional repressor, LexA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220337.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2534"/>
    <dbReference type="EnsemblBacteria" id="AFZ54614">
        <property type="protein sequence ID" value="AFZ54614"/>
        <property type="gene ID" value="Cyan10605_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2534"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2689"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_2_3"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0742">SOS response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="10">
        <location>
            <begin position="77"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="22581" checksum="0233ECAEEE4705EF" modified="2013-03-06" version="1">MENLTPAQKQLYDWLVEYINTNKHSPSIREMMKAMNLRSPAPIQSRLEKMRKKGYLEWTEGQARTLKILKNYHQGLPLLGKVKDGGVVESFSDEQEKIDFGSMFPSSTSYVLQVDGDSMISAYISDGDYLVMGDIEGDKSIKAGEIVTVKAEGYGTMVKRIDYNASKTILTGFNPEEEKITIASNKVEIEGVLLAVFRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D5</accession>
    <name>K9Z6D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRISPR-associated protein, Cas6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220464.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2667"/>
    <dbReference type="EnsemblBacteria" id="AFZ54741">
        <property type="protein sequence ID" value="AFZ54741"/>
        <property type="gene ID" value="Cyan10605_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2667"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2832"/>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063836_0_0_3"/>
    <dbReference type="OMA" id="CWWRISL"/>
    <dbReference type="OrthoDB" id="1403079at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="5">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="275" mass="31424" checksum="263595DA88326A22" modified="2013-03-06" version="1">MPHSLVINFTPISDIPVGYTSGKHLHALFFTLVNSVNPELAQYFHQSEANKSFTVSSLQVISNYKNRDNFLNYKQQNNIKKGSNCWWRITLLDDTLFSKLTKLWLNLRPQKPYHLGSGELMITSVLASPDSHLWANAISYQELYNQASETERNITLKIYTPTAFRQGKYDVSLPTAELVFNSLLRKWEKYSNISFSNANFDCLFPAYFDINTEIIIEPKTKFIGCIGTINYKILGEVETTLIKQINTLADYSFFSGLGRKTTMGFGIIKRLKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G0</accession>
    <name>K9Z6G0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome f</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">petA</name>
        <name evidence="15" type="ordered locus">Cyan10605_2698</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="12 13">Binds 1 heme group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cellular thylakoid membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome f family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220494.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2698"/>
    <dbReference type="EnsemblBacteria" id="AFZ54771">
        <property type="protein sequence ID" value="AFZ54771"/>
        <property type="gene ID" value="Cyan10605_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2698"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2862"/>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033498_0_0_3"/>
    <dbReference type="OMA" id="FWAQQNY"/>
    <dbReference type="OrthoDB" id="744890at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031361">
        <property type="term" value="C:integral component of thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00610">
        <property type="entry name" value="Cytb6_f_cytF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024058">
        <property type="entry name" value="Cyt-f_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002325">
        <property type="entry name" value="Cyt_f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024094">
        <property type="entry name" value="Cyt_f_lg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036826">
        <property type="entry name" value="Cyt_f_lg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01333">
        <property type="entry name" value="Apocytochr_F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16639">
        <property type="entry name" value="Apocytochr_F_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00610">
        <property type="entry name" value="CYTOCHROMEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103431">
        <property type="entry name" value="SSF103431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49441">
        <property type="entry name" value="SSF49441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51010">
        <property type="entry name" value="CYTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Apocytochr_F_N" evidence="14">
        <location>
            <begin position="38"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12 13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="12 13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="12 13">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12 13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602325-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="321" mass="34912" checksum="5E62018361415362" modified="2013-03-06" version="1" precursor="true">MRDNSFFRQISRICLVAIASLSVLLFSNLGLPQAANAYPFWAQETAPETPREATGRIVCANCHLAAKPAEVEIPQAVLPDTVFEAVVKIPYDHSQQQVLGDGSKGGLNVGAVLMLPDGFQIAPEDRIPEEMKEKVNGAYFQTYKEGQDNWIIVGPLPGDQYEEIVFPVLSPDPKNDPNIHYGKYSVHLGANRGRGQVYPTGQLSNNNVFKSTVAGAITNITEAEAGGYTVTINDGETDYSVEIPVGPELIVTEGQEVAVGEALTNDPNVGGFGQKDTEVVLQSPDRIKWLLVFIAGIMLAQILLVLKKKQIEKVQEAGLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H5</accession>
    <name>K9Z6H5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220447.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2650"/>
    <dbReference type="EnsemblBacteria" id="AFZ54724">
        <property type="protein sequence ID" value="AFZ54724"/>
        <property type="gene ID" value="Cyan10605_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2650"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2815"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_2_3"/>
    <dbReference type="OMA" id="HYQPENM"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="185"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="49813" checksum="9E0D2E7694727F12" modified="2013-03-06" version="1">MILLTQPTICPQRRSNLDLNVIPFDNGLTLIHQQIPSSQVVVADVWVNAGVTSEPESWSGISHFLEHMIFKGTKNILPGDFDYVVENSGGCANAATSYDYTHFFLTTAPQYLPKTLPYLAEILLQAEIPEDEFYVERDVVLEEIRSSYDDYDWIILQTVATILYQHHPYRRSVLGEEPLLLENTPNRMRCYHRTHYQPENMNIVLVGNIDRCSATSLVERYFQDFSVRSECPTVNFDSEPPLVDIRREKLYLPRLENPRQVMAWAGPGIENLEGAIALDLLSIILAGGRTSRLVRKLKDELGLVFDICCHFSLQKHSSLFTVTAYLSGSHNLRVEELIRQEISRLQQEAITENELKNCQRILCHDYIFSTETPEQLSALYGYYQILDKANLALQYPHVVKNLTAEKLQGYARQYLSPEYYAICDAYPCRFSPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K6</accession>
    <name>K9Z6K6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein Cyan10605_2298</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220106.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2298"/>
    <dbReference type="EnsemblBacteria" id="AFZ54382">
        <property type="protein sequence ID" value="AFZ54382"/>
        <property type="gene ID" value="Cyan10605_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2298"/>
    <dbReference type="eggNOG" id="COG1615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007733_0_0_3"/>
    <dbReference type="OMA" id="HLRYPQD"/>
    <dbReference type="OrthoDB" id="170146at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="985" mass="113494" checksum="20DD459D97652BB9" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R0</accession>
    <name>K9Z6R0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-oxoprolinase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220603.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2814"/>
    <dbReference type="EnsemblBacteria" id="AFZ54881">
        <property type="protein sequence ID" value="AFZ54881"/>
        <property type="gene ID" value="Cyan10605_2814"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2814"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2991"/>
    <dbReference type="eggNOG" id="COG0145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_3"/>
    <dbReference type="OMA" id="TDCNVML"/>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="2">
        <location>
            <begin position="211"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_B" evidence="3">
        <location>
            <begin position="703"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134648" checksum="2E221C3D28FCCBD5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V9</accession>
    <name>K9Z6V9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219853.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2039"/>
    <dbReference type="EnsemblBacteria" id="AFZ54128">
        <property type="protein sequence ID" value="AFZ54128"/>
        <property type="gene ID" value="Cyan10605_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2039"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2166"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_3"/>
    <dbReference type="OMA" id="QVDPWFL"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938695" evidence="8">
        <location>
            <begin position="25"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="AMIN" evidence="11">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="10">
        <location>
            <begin position="192"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="9">
        <location>
            <begin position="367"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="835" mass="93124" checksum="1D386F8D2A068FC4" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X7</accession>
    <name>K9Z6X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220616.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2827"/>
    <dbReference type="EnsemblBacteria" id="AFZ54894">
        <property type="protein sequence ID" value="AFZ54894"/>
        <property type="gene ID" value="Cyan10605_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2827"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3004"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015106_0_0_3"/>
    <dbReference type="OMA" id="QDVFNYV"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="742" mass="80048" checksum="19AE0938C29CECAE" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X9</accession>
    <name>K9Z6X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220668.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2880"/>
    <dbReference type="EnsemblBacteria" id="AFZ54946">
        <property type="protein sequence ID" value="AFZ54946"/>
        <property type="gene ID" value="Cyan10605_2880"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2880"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3061"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_6_1_3"/>
    <dbReference type="OMA" id="MVIGYGN"/>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17034" checksum="4BAB38429B8B19E1" modified="2013-03-06" version="1">MIEIEKKPTLVIGYGNSLRSDDGIGQKIAIALSQLNLKNLTTIATHQLTPELVEKIIQFEQVIFIDAQINSEKIQITKIDNINSYPQQNWTHHLNPISLINLTNKLYNKFPQGWLITIPIKNTNFGEQISPEVQIMADNIINNLGKNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z0</accession>
    <name>K9Z6Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ54330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220055.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2244"/>
    <dbReference type="EnsemblBacteria" id="AFZ54330">
        <property type="protein sequence ID" value="AFZ54330"/>
        <property type="gene ID" value="Cyan10605_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2244"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2385"/>
    <dbReference type="eggNOG" id="COG3463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566103_0_0_3"/>
    <dbReference type="OMA" id="HEFPPGF"/>
    <dbReference type="OrthoDB" id="1385011at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="82"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="54533" checksum="ACF71BC105BBABA1" modified="2013-03-06" version="1" precursor="true">MKIFFAKYNNIITYILISFFLLFIASSFRHILFNSHAFDLGIFDNGIYLISQGKNPYVSFRELHILGDHAAWILYFIAPFYFLFPSVYWLFFIQSLASAIALIPIWKLSKLNNLSDSKAKTICLIYILYPLIFNVNLFDFHPEVIALPLFFIAILAVKLDKIIWFIVSILLILGCKAVLALNVVMMGVWLILIYRKKNYGAFDVVAPSVIAIFSGIFWFIIATQLIIPAFSGEEAAAVSRYAFLGDSVSEIALNLIIKPQIILSHLFTLANAEYLLLLFLPVIPVLAWQEIPNLIPAIPTLFLNLLTEYQPQKDLVHQYSLPIIPFLIFTIIASLAHHKTWFYQNTKIRIWSLILFLALAKYVYFFPNGLYLKNLHTWKASNEAISLINTSKSVFTAPQFAPHLTHRLTLDLAIDSIDYNQVNKFHYVLLNLDNPTGYSSQEDIKNLINFLEKNREFQLKYNQDNIFLFKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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    <name>K9Z704_CYAAP</name>
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            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54345">
        <property type="protein sequence ID" value="AFZ54345"/>
        <property type="gene ID" value="Cyan10605_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2260"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2400"/>
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    <dbReference type="HOGENOM" id="CLU_739281_0_0_3"/>
    <dbReference type="OMA" id="QLVHMLV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
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    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="42"/>
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    </feature>
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            <end position="355"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="356" mass="40193" checksum="C20191B3F498D1B9" modified="2013-03-06" version="1">MQPTLKPLVTLHLWEKKKLLILSVFIILIILEFKTPPAYVFGYLYTGAILLVNVFYGGKATFIATIVSVFLTLLNLYVHIGTVIELPTLANRLIATLSLIVTGWLSNSNRIYQQKIVEQQTKLQSQEELVRLRQDFASTLTHDLRTPLLGAFETIKAFQNKQFGEITPTQIKVLATMIRSHQSSLQLVNTLLDVYRNDLEGLNLKLYPLDLTVLVEEVANSLTSLASSNQVYLTFNYGDSDFRQSLWVNGDAFQLKRVLTNLLINAINHSRRGDRIEIILSSNTVKILDYGSGIKPDDFSFLFDRFYQSNSDRQAKGTGLGLYLCRQIIEAHGGKIWAENHSKGAIFGFTLPVYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z780</accession>
    <name>K9Z780_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2996</name>
    </gene>
    <organism evidence="8 9">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AFZ55056">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MASE1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="33"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="7">
        <location>
            <begin position="368"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="504" mass="56552" checksum="3A1E21C7CC3F1F2C" modified="2013-03-06" version="1">MKNQSQKGRQLVFLNGGIAIAYIIAIQISHAFTTLPGEVASVWFPSAITLPMVYYYGTKVFSGIIIGSIVGLIPALSSLDPPLSLINSLLLNTICVIANCLQPWFARYLLNKFSRHQEIFTHLSSVLVFIVASFVAPLISAMLGVTGLLIVNALTIGEYPLAFITWWLASALAHILFSPPMIIYREKEVLHQKASYGEIIINLSILCVICIIIFQFAYPLEYLLLPILIWGVFRLNRCNSSLLVSFVAFVAITATGKGYGIFVKSSVNDSLMLLQSFTAMLSLTTLILSAVLSERQIAQQSLKETLENLEIKVFERTRELTQAQLNLKHANHTLKKIANTDSLTQVANRRYFDRRLREEWHNMLVIAHPLSLLLIDIDCFKQYNDTYGHPQGDECLIQVAQTFKSVTRHNSDCIARYGGEEFAIILPNTNQKEAQFIAEKILKEIRKLQIDHKTSTVLKIVTLSIGITTSTPQANDSLEDFIQKADKALYQAKQQGRDRFVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D5</accession>
    <name>K9Z7D5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220825.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3049"/>
    <dbReference type="EnsemblBacteria" id="AFZ55106">
        <property type="protein sequence ID" value="AFZ55106"/>
        <property type="gene ID" value="Cyan10605_3049"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3049"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3247"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_20_3_3"/>
    <dbReference type="OMA" id="QIFMIYF"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="308"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="513" mass="56533" checksum="F763861A74CF5E24" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J0</accession>
    <name>K9Z7J0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynS</name>
        <name evidence="5" type="ordered locus">Cyan10605_3108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220880.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3108"/>
    <dbReference type="EnsemblBacteria" id="AFZ55161">
        <property type="protein sequence ID" value="AFZ55161"/>
        <property type="gene ID" value="Cyan10605_3108"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3108"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3312"/>
    <dbReference type="eggNOG" id="COG1513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103452_1_0_3"/>
    <dbReference type="OMA" id="FLPYKAW"/>
    <dbReference type="OrthoDB" id="1506439at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="16556" checksum="C453903352D4B1AC" modified="2013-03-06" version="1">MTIAEITKTLLDAKKAKGVTFAQLEEILGRDEVWIASVIYRQASADETEAKKLVEALGLSPEFAEELTIPPLKGSLDPVIPTDPLIYRFYEIMQVYGMPMKEVIHEKFGDGIMSAIDFTLDVDKVEDPKGDRVQVTMCGKFLPYKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J8</accession>
    <name>K9Z7J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220843.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3067"/>
    <dbReference type="EnsemblBacteria" id="AFZ55124">
        <property type="protein sequence ID" value="AFZ55124"/>
        <property type="gene ID" value="Cyan10605_3067"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3067"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3269"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505089_0_0_3"/>
    <dbReference type="OMA" id="GHLNAFR"/>
    <dbReference type="OrthoDB" id="482318at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="1">
        <location>
            <begin position="89"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="526" mass="58428" checksum="E7E194A9747E0E82" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K2</accession>
    <name>K9Z7K2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220097.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2289"/>
    <dbReference type="EnsemblBacteria" id="AFZ54373">
        <property type="protein sequence ID" value="AFZ54373"/>
        <property type="gene ID" value="Cyan10605_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2289"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2431"/>
    <dbReference type="eggNOG" id="ENOG50303EG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1569943_0_0_3"/>
    <dbReference type="OMA" id="YERVYTQ"/>
    <dbReference type="OrthoDB" id="1603621at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938699" evidence="1">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="171" mass="18832" checksum="ACB869A0389074B7" modified="2013-03-06" version="1" precursor="true">MFKKKISHLIVSVSLLFLLTLTACSPQPPSRFEQAQQDSIAAGNKNTAVSKDAVKGASFNQFFPVSSGDYERVFTQEKTGFVQAKLKFQGQDVATLAIFDTISNPTAKNDFANATETIKGFPTVEKGSNNTAVLVGDRYQVSIRSSDPNFTAEERKEWLNKFDLANLAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N5</accession>
    <name>K9Z7N5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220455.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2658"/>
    <dbReference type="EnsemblBacteria" id="AFZ54732">
        <property type="protein sequence ID" value="AFZ54732"/>
        <property type="gene ID" value="Cyan10605_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2658"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_2_3"/>
    <dbReference type="OMA" id="MRRDELY"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="13334" checksum="96720776F5F196BB" modified="2013-03-06" version="1">MRNDSERIRDIRECIEKIEKYSVRGKKEFYEDELIQTWIIHNLQIIGEASRATSEEFKAKYPQVLWLKIADFRNLLVHEYFRVDLGIVWEIVENELPKLKQQINDILRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P6</accession>
    <name>K9Z7P6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220914.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3145"/>
    <dbReference type="EnsemblBacteria" id="AFZ55196">
        <property type="protein sequence ID" value="AFZ55196"/>
        <property type="gene ID" value="Cyan10605_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3145"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3352"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029517_1_1_3"/>
    <dbReference type="OMA" id="IQFDDHL"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="4">
        <location>
            <begin position="45"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="474" mass="54136" checksum="EA4013FC36EFBE15" modified="2013-03-06" version="1" precursor="true">MSSFLSRQWLSLHVFKFLSLFFASYFSILLIGFWNAPIFSQDVPEIRAVWLTTSDTDTLLDRPKMKEAIASLASLHFNTIYPVVWNSGYALYPSKVAQEAKIQPFVHKGLQGQEPLGELIEEAHRYKMLVLPWFEFGFMAPPSSELALKHPNWLTKAQDGTQTTYSAAGEVVWLNPFHPEVQKFITALVMEVVNNYDIDGIQFDDHLCLPVQLGYDAYTVNLYKQETGLEPPKNYKDANWMRWRANKLTEFVAQLNQTIKAQNPNKILSISPNPYHTAYNSFLQDWLDWVRKNLIDELIIQVYRSDFAVFQKEITRPEIKEAKEKIPVGIAILTGLPNRITPIEFVKEKALAVRRQKLGIAFFFYGSMWNTSPELKNDHEMALRDRKSSFQSLFPYQPRRIVTVNPNTPIITPTNSVIPVTPSNPVTPVTSTNNVVNPVNKVTPTNPPIIDSSIDPTNVTSEPIPIDEFLEFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q5</accession>
    <name>K9Z7Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phycocyanin, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220924.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3155"/>
    <dbReference type="EnsemblBacteria" id="AFZ55206">
        <property type="protein sequence ID" value="AFZ55206"/>
        <property type="gene ID" value="Cyan10605_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3155"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3362"/>
    <dbReference type="eggNOG" id="ENOG502Z85C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="YLRFITY"/>
    <dbReference type="OrthoDB" id="1513296at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006246">
        <property type="entry name" value="Phycocyanin_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01338">
        <property type="entry name" value="phycocy_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3 4" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2 4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="17424" checksum="872E4906D3CC2770" modified="2013-03-06" version="1">MKTPLTEAVSAADSQGRFLSSTEIQTAFGRFRQATASLQAAKSLTENAQRLIDGAANAVYNKFPYTTSTPGSQYASTAEGKAKCARDIGYYLRMVTYCCVAGGTGPMDEYLIAGIDEINRSFELSPSWYIEALKFIKANHGLSGDAAVEANSYIDYAINALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S1</accession>
    <name>K9Z7S1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protease 4</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endopeptidase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Signal peptide peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220893.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3123"/>
    <dbReference type="EnsemblBacteria" id="AFZ55174">
        <property type="protein sequence ID" value="AFZ55174"/>
        <property type="gene ID" value="Cyan10605_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3123"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3329"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_3"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="6">
        <location>
            <begin position="128"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="6">
        <location>
            <begin position="373"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="595" mass="65684" checksum="4166B6AAC33FF557" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T1</accession>
    <name>K9Z7T1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220959.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3192"/>
    <dbReference type="EnsemblBacteria" id="AFZ55241">
        <property type="protein sequence ID" value="AFZ55241"/>
        <property type="gene ID" value="Cyan10605_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3192"/>
    <dbReference type="eggNOG" id="ENOG5031BER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126044_1_0_3"/>
    <dbReference type="OMA" id="LVWQSRN"/>
    <dbReference type="OrthoDB" id="1612418at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="15269" checksum="372BDA20E1A2F063" modified="2013-03-06" version="1">MNKADQNMPEVTEAQIERLYQLKIYLRWILVVCAWILILPWSLWQFRETISLCQERCTWAAIRVGIEFTPLGALGIAFCMGFTTSVLVWQSLHILRGGLSNKEKYYLRQEMVKILQQGEKHWLYRYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T8</accession>
    <name>K9Z7T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220908.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3138"/>
    <dbReference type="EnsemblBacteria" id="AFZ55189">
        <property type="protein sequence ID" value="AFZ55189"/>
        <property type="gene ID" value="Cyan10605_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3138"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3345"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_3"/>
    <dbReference type="OMA" id="ERVDLWQ"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="376" mass="41275" checksum="F9092B6C9FBEEAD4" modified="2013-03-06" version="1">MRIALFTETFLPKVDGIVTRLKHTVEHLQKQGDEVLIFSPEGGLKEYKGAKINGIKGIPLPLYPELKLAIPNPSIGFSLRRFKPDLVHVVNPAVLGLGGIFYAKKYDIPLVASYHTHLPQYLHHYNLGALEGLLWEMLKLAHNQARLNLCTSTAMVNELESHGIERVDLWQRGVDTDSFHPDLISNQMRDRLSGGNPDAPLLLYVGRVSAEKEIDKIKPVLENIPNARLAIVGNGPAREELEALFAGTNTNFVGYLHGQDLGSAYASADAFIFPSSTETLGLVLLEAMAAGCPVVAARRGGIPDIVTDGVNGYLFEPDDPQGAIAATQKLLAKTDEREQLRQNARKEAEKWGWASATTQLRNFYQGVLSRDIGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V5</accession>
    <name>K9Z7V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase nickel insertion protein HypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3219"/>
    <dbReference type="EnsemblBacteria" id="AFZ55266">
        <property type="protein sequence ID" value="AFZ55266"/>
        <property type="gene ID" value="Cyan10605_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3219"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3432"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_4_1_3"/>
    <dbReference type="OMA" id="MHETDMT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12848" checksum="A696B1652ADE6781" modified="2013-03-06" version="1">MTKALIMTITDWYESQPQPYKIDKVHLLVGDFTCVEPASLEFAFEVQTKNTFLEGAKLAIKNIPLVAFCHNCNEEYQPEIGLQYSCPKCHSPMDDIRSGRELKIDRLEYSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W0</accession>
    <name>K9Z7W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3168"/>
    <dbReference type="EnsemblBacteria" id="AFZ55219">
        <property type="protein sequence ID" value="AFZ55219"/>
        <property type="gene ID" value="Cyan10605_3168"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3168"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3376"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="NVATNRI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="338"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="477" mass="54020" checksum="80758105601F27F7" modified="2013-03-06" version="1">MDPFFSPMSAVEISSEEKLTESILIVDDQPANLRVLSQMLQIKNYKVKKAADGESAILAAKSSPPDLILLDILMPDLNGYEVCRKLKADNLTKDIPVIFISALSDVFDKVKAFEVGGIDYITKPFQEEEVLARIGSQLTIQKQKKLLEKEQEKLKKEREHLRKEIRQRKEAEAILYQSRAIISSILNSSLDAIAALEAVRDPASGNILDFRCLVVNPITAQIFNRQPEDLTGKLLFKKFINQIKPELFFEFIKVVETGKSLDKEIEYNYKKQHKWFHCIAVKLGDGFSVTVRDITERKKLELKLSKLATIDSLTGVYNRHSFDKILKQEWQRCGRGKQPLSLIICDIDFFKPYNDFYGHQAGDKCLIEVAKTMSNIVRRTSDFLARYGGEEFAIILPNTPQQGAFNVAENIRQEIEALQLPHEKSKISNYITFSLGVATIIPTQDVSLESLIKSADNALYSAKKSGKNQTQLGELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W6</accession>
    <name>K9Z7W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3235"/>
    <dbReference type="EnsemblBacteria" id="AFZ55281">
        <property type="protein sequence ID" value="AFZ55281"/>
        <property type="gene ID" value="Cyan10605_3235"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3235"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3449"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="AGLDWSM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="26993" checksum="4F2DAA28ED875E16" modified="2013-03-06" version="1">MYERSELSEPPNMLYLKNVSYHPAAIPHPIIQDINITLPPQKLGLIIGVSGSGKTTLLEILAGLAEKTSGQILWRTQELTSEDLQQLSGIVFQFPERHFCGATVLEELRLGHPELSATRIKETLTEVGLEQINYDTPPHALSGGQQRRLSLAVQLIRQPNILLLDEPTAGLDWLMKRQLVTLLSRLKKHWTLLIVTHDASDLIDIADNCWRLEEGRLESVNQDTLKPLNKMEVDFDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F7</accession>
    <name>K9Z8F7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2575"/>
    <dbReference type="EnsemblBacteria" id="AFZ54653">
        <property type="protein sequence ID" value="AFZ54653"/>
        <property type="gene ID" value="Cyan10605_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2575"/>
    <dbReference type="eggNOG" id="ENOG5033C1W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191301_0_1_3"/>
    <dbReference type="OMA" id="VICHQAD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="57" mass="5799" checksum="5021D5B6999150A9" modified="2013-03-06" version="1" precursor="true">MRDNQGKDLVGAGLTAAIGAGIITSYAVSQGQHPLVATGITIFSALLAVIIYQADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M4</accession>
    <name>K9Z8M4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">petB</name>
        <name evidence="8" type="ordered locus">Cyan10605_3018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="5">Binds 2 heme groups. One heme group is bound covalently by a single cysteine link, the other one non-covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">Heme 1 (or BH or b566) is high-potential and absorbs at about 566 nm, and heme 2 (or BL or b562) is low-potential and absorbs at about 562 nm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome b family. PetB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220796.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3018"/>
    <dbReference type="EnsemblBacteria" id="AFZ55077">
        <property type="protein sequence ID" value="AFZ55077"/>
        <property type="gene ID" value="Cyan10605_3018"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3018"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3216"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_0_2_3"/>
    <dbReference type="OMA" id="WATQTGM"/>
    <dbReference type="OrthoDB" id="1339825at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00633">
        <property type="entry name" value="Cytb6_f_cytb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023530">
        <property type="entry name" value="Cyt_B6_PetB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF20">
        <property type="entry name" value="PTHR19271:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="7">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="222" mass="25100" checksum="5EBDE04E353D1B3F" modified="2013-03-06" version="1">MFTKQVTDSPVYKWFNDRLEIEAISDDISSKYVPPHVNIFYCLGGITLTCFLIQFATGFAMTFYYKPTVTEAFSSVQFIMNEVNFGWLIRSIHRWSASMMVLMLILHVFRVYLTGGFKKPRELTWIVGVTMAVITVSFGVTGYSLPWDQVGYWAVKIVSGVPAAIPVVGDQMVELLRGGASVGQATLTRFYTIHTFVLPWLMAVFMLLHFLLIRKQGISGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P8</accession>
    <name>K9Z8P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2908"/>
    <dbReference type="EnsemblBacteria" id="AFZ54970">
        <property type="protein sequence ID" value="AFZ54970"/>
        <property type="gene ID" value="Cyan10605_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2908"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043536_0_0_3"/>
    <dbReference type="OMA" id="WYLFAEF"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039342">
        <property type="entry name" value="TGD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34675">
        <property type="entry name" value="PTHR34675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="433" mass="47336" checksum="6CAA7805120A8604" modified="2013-03-06" version="1" precursor="true">MIRSRLMREGSVGLFLLLGLLVFGGIVFFLKKDQLRGSNYQIKLMFENAGGLREGARVFFRGVAVGRVASIQPTSNGVEVWTEINNKLPIPRDVIVSTTRSGLLGEVSVNIIPQGVLSNVGEDINPLGKECEQKQLILCNNEKIPAQASPDLIESLARLADSFDDETFFENLNTAVDNTNKATEQFIVLTQEVTGVTNRVQKEMDTISNTFTSIGRTADSLSNTANTLSNTANTATTQIEKLGSEYTNTAIQINLLASNLNQIIADNKTDFQNAIASLSQTATDISQVAQTTNNLVAKIDEKDVQKITQNLGTTSENLAQISSDLKTIADELNNPTNLATLQQTLDSARVTFANTAKITSDIDQFTGDPQFRRNLKNLVDGLSNLVSYTDLLEKQVELAILLEELDKETAKSSKDKWGITSQKLPNTIETITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S7</accession>
    <name>K9Z8S7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221279.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3531"/>
    <dbReference type="EnsemblBacteria" id="AFZ55564">
        <property type="protein sequence ID" value="AFZ55564"/>
        <property type="gene ID" value="Cyan10605_3531"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3531"/>
    <dbReference type="eggNOG" id="ENOG502ZB6U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965476_0_0_3"/>
    <dbReference type="OMA" id="VINHIGG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="32582" checksum="85765455EB9FAC66" modified="2013-03-06" version="1">MTTRFSNELYFTDGSIGELKTVTTWNVWDCASMQWTGSPPVVLRNILLAGLHPRLLMAIGEIQKTDTNPNLLNPFVPSNYPKQYLDLASNSRTHGRFTFNQNPIGSYYYGEDWKRIIYGSIVHTGCKKLIYKDIYYLVVDDENRDENGDYMDDPVNNYHWFTGDSHAKASAELMELLGLPRDKDGVINHIGGFVDVRKPIQFRAAFFGKWVGKGTIAHNPVLDITYDGSIIQGLEEEAKIDLVIPLSSLKGNKPKLGVHKGKILMGLVFEAEKRKAKPGWMLFHIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z913</accession>
    <name>K9Z913_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2801"/>
    <dbReference type="EnsemblBacteria" id="AFZ54868">
        <property type="protein sequence ID" value="AFZ54868"/>
        <property type="gene ID" value="Cyan10605_2801"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2801"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768872_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="360" mass="42556" checksum="959C4852EEE966B5" modified="2013-03-06" version="1">MYDRSYFYSCENLFYELLNPIFMSIRDNIYGLFQDRISDLDSGNFVNREEYIYLLRQTIREYQESQIKLKLIEIDAQWDLHHWQGILSRKETENLLGKKDTLLILFSPPELSPDVPPSIQNNLPVEFKSIKDKLKLFYSEKDYNYGVKFYTDITDYNCRFSLGFWNDKSYEPTIISSPLWNWEKTFNKFFKIGLDEKQSFRAIRELIIIYNQLLASYFIDTFYVSIDPYYPLKFPIFTTHLAKELIRNKECVECYFLQLKQMQEEELIILEEIAQKKEQNLKGNVNQWKVLNTIKVRGDYPIYSIAIHPNDDIIASACGYDGIQEFDIYSGELLNITMSNHHSVIAVAYDCSGESLICGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z929</accession>
    <name>K9Z929_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">Cyan10605_3166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220935.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3166"/>
    <dbReference type="EnsemblBacteria" id="AFZ55217">
        <property type="protein sequence ID" value="AFZ55217"/>
        <property type="gene ID" value="Cyan10605_3166"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3166"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3374"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_3"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="542" mass="61103" checksum="5AE3667BE88BA924" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9D1</accession>
    <name>K9Z9D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3129"/>
    <dbReference type="EnsemblBacteria" id="AFZ55180">
        <property type="protein sequence ID" value="AFZ55180"/>
        <property type="gene ID" value="Cyan10605_3129"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3129"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3335"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_3"/>
    <dbReference type="OMA" id="AICPSWV"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="228" mass="25453" checksum="427BE4FAE62C3480" modified="2013-03-06" version="1">MNVILISGASRGIGRSIAEKLLQDGYYLSLGVREPNYFQNTVFANHERVLIQPYEAKDKQSPIDWVKATIDKFGRLDGLINCAGILERIQFEDDNEEGLDRLFEVNVKAPWRLTREAFPYLKQSGKGRIINLVSMSGKRVKGTLAGYSMSKFAFLALSQSMRNAGWEDGIRVTAICPSFVNTDMAKGVKLDSETITQPEDVADIVKTILKLPNTAYVGEVLINFALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G5</accession>
    <name>K9Z9G5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221085.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3322"/>
    <dbReference type="EnsemblBacteria" id="AFZ55367">
        <property type="protein sequence ID" value="AFZ55367"/>
        <property type="gene ID" value="Cyan10605_3322"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3322"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3537"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182997_0_0_3"/>
    <dbReference type="OrthoDB" id="2022133at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8632" checksum="394AF6DAE5967B4F" modified="2013-03-06" version="1">MRYKYTAKYTKIPSGYMGQIIEWQEVITEGKSLRECRFLLEDALNEMILAYQQQGKTIPLNDEDIIETLSIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G7</accession>
    <name>K9Z9G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220933.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3164"/>
    <dbReference type="EnsemblBacteria" id="AFZ55215">
        <property type="protein sequence ID" value="AFZ55215"/>
        <property type="gene ID" value="Cyan10605_3164"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3164"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3372"/>
    <dbReference type="eggNOG" id="ENOG5030P5G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105888_0_0_3"/>
    <dbReference type="OMA" id="PLWGNFP"/>
    <dbReference type="OrthoDB" id="1447768at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="24076" checksum="36D7AF25E9588E4A" modified="2013-03-06" version="1">MNNQQPLIVIIGGFHNLEITINFVKYLYSQIKAIKDLKYIIIPTDKVQPLDGLSAYNFLSNYLVNQSCFPCPIIVISFSAGVVGAIILGKLWKAWNGEVLCLLAFDGWGVPLIADFPCYRVSHDHFTHFSSLLLGGEESSFYAQPMVNHLELWRSPLEIQGRWQMKLGVEKTVKMTDFIQFCLQKEIDKYIKKCKKYPETEAKNNHKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9T0</accession>
    <name>K9Z9T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221058.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3294"/>
    <dbReference type="EnsemblBacteria" id="AFZ55340">
        <property type="protein sequence ID" value="AFZ55340"/>
        <property type="gene ID" value="Cyan10605_3294"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3294"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3509"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056210_0_0_3"/>
    <dbReference type="OMA" id="GNYLSAW"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="30226" checksum="841108E0D74B0C42" modified="2013-03-06" version="1">MFYYEGQFYEGNSISLNINDSTWLYGATVFTTMRVYKQSLNHPLTNWQKHCDRLLKSIEELNWTFPDWQLIKQEVEQLLIYFPVIRITVFPDGRELIIGRQLPTNLFQKQQEGIKGLVCLNPSIQRSIPEHKTGNYLAPWLALQQAQKQGYQEAILTNIEHNWLETSTGNLWGYKQGIWFTPNLAQGILPGIARQTIIDKAQFPIEINQWTPDFINDLEAIAYSNSVIEIIPFHKIINGEKVIDYDHNHPAYKALKGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W7</accession>
    <name>K9Z9W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220882.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3110"/>
    <dbReference type="EnsemblBacteria" id="AFZ55163">
        <property type="protein sequence ID" value="AFZ55163"/>
        <property type="gene ID" value="Cyan10605_3110"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3110"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3314"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054193_6_0_3"/>
    <dbReference type="OMA" id="ANRIFAM"/>
    <dbReference type="OrthoDB" id="1593541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="175"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="322" mass="36065" checksum="1C182E31AD391FFF" modified="2013-03-06" version="1">MKKFWQFLGSNFQIVNFFLASIIIGGLFGFWYLPQSSQKENTNINNPPPSVTKITPTNSPETATESPLTIANSPRNNPETPVDNTSVTPSSTSNNSTASITPPATVNNTTIATLPTTKQEKVNNPVNSSQSPEIEDQELAKINYLLSSTYFGHFPFQEAPQARLVNMGKYYNRTEYLDREAGEAFLRMKAAAKTQGVELILISGFRSISSQTQLFQKQIQKRGSKEEAVKLSAPPGHSEHHTGYALDIGDGKQPSLDLKTQFQSTQAYQWLSNNAHKYGFELSFPPNNLQGVSFEPWHWRFVASDRANRIFAMPRHLLYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA23</accession>
    <name>K9ZA23_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220916.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3147"/>
    <dbReference type="ESTHER" id="cyaap-k9za23">
        <property type="family name" value="Duf_1350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55198">
        <property type="protein sequence ID" value="AFZ55198"/>
        <property type="gene ID" value="Cyan10605_3147"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3147"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3354"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047079_1_0_3"/>
    <dbReference type="OMA" id="ATPFVNT"/>
    <dbReference type="OrthoDB" id="1187694at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010765">
        <property type="entry name" value="DUF1350"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127">
        <property type="entry name" value="PTHR34127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07082">
        <property type="entry name" value="DUF1350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="31283" checksum="3701D9EF59AD7088" modified="2013-03-06" version="1">MEWQEFSGSWVLTPPHPLGIIHFLGGAFVATAPHITYRWLLEKLARQGYIIIATSFLNTLDHKAIAVNVQNRLENILYRLEYKQGIDINYLPIYGLGHSMGCKLHLLIGSLLKVERAGNILISFNNYPFKKAIPFAENIIPYLQDNIKNYLQLEANLDIDFTPTPIETNIIIKENYHIRRNLLIKFSDDTIDQTLELHPILKQLHPNMITALQLSGNHLTPLGQDIDWEMGGQLFSPIAGISQWFQDNFSRDLYNLYQQISRWLNPCPDVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA73</accession>
    <name>K9ZA73_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3458"/>
    <dbReference type="EnsemblBacteria" id="AFZ55495">
        <property type="protein sequence ID" value="AFZ55495"/>
        <property type="gene ID" value="Cyan10605_3458"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3458"/>
    <dbReference type="eggNOG" id="ENOG5032UBP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129905_0_0_3"/>
    <dbReference type="OMA" id="LCYQVCF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="14272" checksum="15FEE5B76A6C5344" modified="2013-03-06" version="1">MIEPKFKNAQEYELAQVLMQPIFIRLLDNIRKESELSNYDVSYEEINEPFPSYIVAIKKENKTEKNNVWELCFQVCFNNYSESTTQPVTTDKTLFEEDGQLNWQTLDEKTKTLVKSLFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAN2</accession>
    <name>K9ZAN2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55453">
        <property type="protein sequence ID" value="AFZ55453"/>
        <property type="gene ID" value="Cyan10605_3411"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3411"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3635"/>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="8904" checksum="9A2C966F1ADB4114" modified="2013-03-06" version="1">MDLVLICYQLTSQFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAS9</accession>
    <name>K9ZAS9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein PatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls heterocyst pattern formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nitrogen starvation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221216.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3461"/>
    <dbReference type="EnsemblBacteria" id="AFZ55498">
        <property type="protein sequence ID" value="AFZ55498"/>
        <property type="gene ID" value="Cyan10605_3461"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3461"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3686"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031371_0_0_3"/>
    <dbReference type="OMA" id="TISCERN"/>
    <dbReference type="OrthoDB" id="806256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043158">
        <property type="term" value="P:heterocyst differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024186">
        <property type="entry name" value="Sig_transdc_resp-reg_PatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005897">
        <property type="entry name" value="RR_PatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0364">Heterocyst</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="277"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="396" mass="45128" checksum="C515BFF9238B4CFB" modified="2013-03-06" version="1">METPNQENHSSIPIKGFVASKQSYLFNVLKKHQFSGELQLVHPGKEQWRFYLYMGRLICATGGNHSVRRWRRNLAAFLPEVASDQVFLEQEIKSISSDKIKFCWEYELVRHWLLEGKVGRDGVIKMVNNIFIEIFFDLNQTLEISFFLNSKVHIPLEEQICLLDASQVIVPAWQQWQQWVNLRLGDRSPNKAPVIRSAKQLQAKTSPKTYEIFQKLFNGRNTLRDLAVQFKRDLPQFSSSLLPYIQQGYIDLVSVADLPAPISPVTEVQEAETATPLIACIDDSPLICETMNIILKKAGYRFLGITEPLKAIAKILASKPDMIFLDLVMPDTNGYEICASLRKLSLFRNTPIIILTSNDGMIERVRSKIIGASDFMAKPINPEEVLVIVNKHLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ44</accession>
    <name>K9YZ44_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily (Subfamily IA) hydrolase, TIGR01548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0040"/>
    <dbReference type="EnsemblBacteria" id="AFZ52201">
        <property type="protein sequence ID" value="AFZ52201"/>
        <property type="gene ID" value="Cyan10605_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0040"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.42"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065007_0_0_3"/>
    <dbReference type="OMA" id="GIWNNDW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006438">
        <property type="entry name" value="HAD-SF_TIGR01548"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01548">
        <property type="entry name" value="HAD-SF-IA-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="270" mass="31023" checksum="4A25B2D2D5B03E96" modified="2013-03-06" version="1">MGEGKIKIKINKNLMSAIVIFDIDGVIRDVTNSYRRALADTVEHFTNNHYRPSMEDIDSLKAEGIWNNDWLGSQELIYRYFEQMGKSRDEINLNYEEIVDFFQRRYRGQNLEQPTSWDGYISSEPLLVSREYFEILDKNNLYWGFFSGATNGSAQYILQRRLGLENPVLVAMDDAPSKPDPTGLFLAVNLLEEKLSLDNSLPVIYLGDTVADIITVMKAKEIKPEREWIAVGVLPPHVSNDNEKGDKYRQQLIDSGASFVVNQITDFYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ48</accession>
    <name>K9YZ48_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217906.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0013"/>
    <dbReference type="EnsemblBacteria" id="AFZ52174">
        <property type="protein sequence ID" value="AFZ52174"/>
        <property type="gene ID" value="Cyan10605_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0013"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.14"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559980_0_0_3"/>
    <dbReference type="OMA" id="SYPHPMI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="508" mass="59203" checksum="BA0CCF66155747F6" modified="2013-03-06" version="1">MNQRDLSEGKLLVQRYLLREVVGVGGMGTVYRAQDIASKNHNVAVKILSRSLDNMKMIKQFQREATFSALLSERSQNIVKVTDYGVDEQKVPFYVMEFLEGENLDDMIEVHDISLPQFFDFICQICRAMETAHNGIFFEGEIYPVIHRDLKPSNVFIIEDDTGKQIIKVLDFGIAKLVKDDPIDTENFMGTPKYCSPEQLQGKDLDNRSDIYSLGMIMYLMLCKKLPWNLEVESVGLWYKAHTELSPKPFPPELNISSDLEKLVLQCLEKSPSNRPQNVGEIIQRLESIAKKLKIVKKTISEGQNHLLNINNNFVESYENTNPKEDFLLSHPWPKNKPKQKIVFPRVVFYQNSSLPTICTMLETEDIRKRKNNIRYSQFLFQSYPHPMILWITLLYSPKHEPRWFPCYLDLKAKIGQQLVSTLSESKEYFVLFYSLEKPHKCIDLQPFKIMLKQRTSLKQWMSVSNMISVKHDDEVLFSRRKLKQDLEALKPKIIIDLEKTNTLEVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZX7</accession>
    <name>K9YZX7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218237.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52506">
        <property type="protein sequence ID" value="AFZ52506"/>
        <property type="gene ID" value="Cyan10605_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0361"/>
    <dbReference type="HOGENOM" id="CLU_204727_0_0_3"/>
    <dbReference type="OMA" id="ALLHCFI"/>
    <dbReference type="OrthoDB" id="2078257at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="63" mass="6774" checksum="294EA38A46E24B2A" modified="2013-03-06" version="1">MIEILTNPDPNTVFWLMLLHCIIGLSAGIVADIKGYSFPLWLGIGTVAGTFGLIASLTLKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z068</accession>
    <name>K9Z068_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="12" type="ordered locus">Cyan10605_0454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218327.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0454"/>
    <dbReference type="EnsemblBacteria" id="AFZ52596">
        <property type="protein sequence ID" value="AFZ52596"/>
        <property type="gene ID" value="Cyan10605_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0454"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.480"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_3"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="324" mass="35908" checksum="EB15905CAB66DBEB" modified="2013-03-06" version="1">MAKTAQKRTFLLEFEKPLVELQARIDQIRELGEEKQLDVSGQLQELEGKVEQLRQEIFSTLTPAQKLQIARHPRRPSTLDYVQAMCDEWLELHGDRRGSDDLALIGGIARLEGRAVVIIGHQKGRDTKDNVARNFGMASPGGYRKAMRLMEHANRFSMPIITFIDTPGAYAGVEAEKLGQGEAIARNLREMFSLEVPIISTVIGEGGSGGALGIGVAEKLMMFEHSVYTVASPEACAAILWKDAKKSEQAAQALKITAYDLKDLGIIDQILPEPPGCAHSDPLATAEILKQAILENLEYLSQLPTDKLKELRYQKFRNIGVFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0L5</accession>
    <name>K9Z0L5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218457.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0587"/>
    <dbReference type="EnsemblBacteria" id="AFZ52726">
        <property type="protein sequence ID" value="AFZ52726"/>
        <property type="gene ID" value="Cyan10605_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0587"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.619"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037606_0_0_3"/>
    <dbReference type="OMA" id="YIAIVHI"/>
    <dbReference type="OrthoDB" id="890258at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="587" mass="66890" checksum="7427FB78E4A3F89D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0M1</accession>
    <name>K9Z0M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0113"/>
    <dbReference type="EnsemblBacteria" id="AFZ52272">
        <property type="protein sequence ID" value="AFZ52272"/>
        <property type="gene ID" value="Cyan10605_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0113"/>
    <dbReference type="eggNOG" id="ENOG502Z8D1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054940_1_1_3"/>
    <dbReference type="OMA" id="LKKSYYW"/>
    <dbReference type="OrthoDB" id="1549088at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="22751" checksum="D83B99AC9E805DD7" modified="2013-03-06" version="1">MSVINSSDFSANSNPDSTFLLDHPAIGIPDHPLQYRAIGVIQGIYEPSQNALTKGIITTADNQTFNTVLLGKTIGAVKNHVDLDQVQNWVVYPHTIPDTDNIHFQIAGIYQPQTNIPEILPDNYFSIRGDIAYSSKYKEKVIVKINQGQSRQRPNYFKLELKGKIPNNQIRHFFTFSACLEGKILRIKKYLDLGLIGFNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N0</accession>
    <name>K9Z0N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase, SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218014.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0125"/>
    <dbReference type="EnsemblBacteria" id="AFZ52282">
        <property type="protein sequence ID" value="AFZ52282"/>
        <property type="gene ID" value="Cyan10605_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0125"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_3_1_3"/>
    <dbReference type="OMA" id="SQMFWLT"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="164" mass="18418" checksum="E0D24D982B788621" modified="2013-03-06" version="1">MKIYLIRHGIAESRAMEKNDSQRILTRKGITKTQKVAQKLTNLDIEFDVIITSPYTRAKETAIILQQAKRSLNIVEHSALIPQGNILEWFNWLQTSPYKSAGNIALIGHEPDLSEWAQLLIWGKTEDKLILKKAGIIGLEVADLSNPLGTAQLFLLASPKWISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0W6</accession>
    <name>K9Z0W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional attenuator, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218535.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0666"/>
    <dbReference type="EnsemblBacteria" id="AFZ52804">
        <property type="protein sequence ID" value="AFZ52804"/>
        <property type="gene ID" value="Cyan10605_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0666"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.702"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_5_1_3"/>
    <dbReference type="OMA" id="YVPKDMK"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="129"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="372"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="53716" checksum="8D2157E972FBAD2D" modified="2013-03-06" version="1" precursor="true">MSEGKSKRQSNQYQHQNNSKKESSLKFNPRWLFLGFGFSAIAVVSASVGALLALSLSKTPLRQAQLTPAEEAVFNQEETVTFDSLQIPKLSRPVNILVLGIKVLTSDVPEQAHPDVGYHALVNSFEGLSDSMLLLRFDPEKDNVVVLSIPRDTKTLIPQRGVTKINEANALGGPALAAESVSNLLDDVSVDRYIRINIQGVEKLIDALGGLNIYVPENMKYTDHSQHLYIDLKQGQQHLDGEKAIQFLRFRYDAYGDIGRVQRQQSFMRALVEQTLSPRTILRMPDILNVVRSHLDTNLTTNELIALAAFAAQKNRSDVKMVMLPGDFNTPGEGELSYWLPNHDKISEVMAQHFEVGSNYFSANYQSDSHNLKIAVQSTKDDQEVAQKIVQYLKDNGYSRAYFSYNYYPHNLPETKIIAQQGDNLAAAQLRADLGVGEVVVESTGVINSDVTIQVGSDWSRSHANPANDNDNNENNFQTISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z108</accession>
    <name>K9Z108_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase</fullName>
            <shortName evidence="8">FBPase class 2/SBPase</shortName>
            <ecNumber evidence="8">3.1.3.11</ecNumber>
            <ecNumber evidence="8">3.1.3.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17461"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:58335"/>
            <dbReference type="EC" id="3.1.3.37"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="8"/>
    <dbReference type="EC" id="3.1.3.37" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218580.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0713"/>
    <dbReference type="EnsemblBacteria" id="AFZ52849">
        <property type="protein sequence ID" value="AFZ52849"/>
        <property type="gene ID" value="Cyan10605_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0713"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.746"/>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_3"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="UniPathway" id="UPA00116"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="346" mass="37455" checksum="9832C2A3FB129ADB" modified="2013-03-06" version="1">MLETTLGLEIIEVVEQAAIASSKWMGKGEKNIADQVAVEAMRERMNRIHMRGKIVIGEGERDDAPMLYIGEEVGFCTQPDAEKYCNINELVEIDIAVDPCEGTNLVAYGQNGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGHVDINKSATENLKILSDCLNRDTEELVVVVMDRPRHKELIQEIRNTGARVRLISDGDVSAAISCAFSGTNIHALMGIGAAPEGVISAAAMRCLGGHFQGQLIYDPEIVKTGLIGESKESNLARLRDMGIENPDKVYETEELASGETVLFAACGITPGTLMDGVRFFHGGARTQSLVISTQSKTARFVDTVHMFDKPKVIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C7</accession>
    <name>K9Z1C7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218700.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0837"/>
    <dbReference type="EnsemblBacteria" id="AFZ52969">
        <property type="protein sequence ID" value="AFZ52969"/>
        <property type="gene ID" value="Cyan10605_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0837"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.880"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_3"/>
    <dbReference type="OMA" id="DQALDIC"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="37061" checksum="DC8422A0D6CD439E" modified="2013-03-06" version="1">MSDIPFSLDQLRILKAIADEGSFKRAADSLFVSQPAISLQIQNLEKQLSVPLFDRGGRKAQLTEAGNLLLAYGEKIITLCQETCRAIEDLQNLQGGTLIVGASQTTGTYLLPRMIGLFHQKYPYVSVQLQVHSTRRTSWAVANGQVDLAIIGGEVPTELHDVLEIIPYAEDELALIIPPNHPLAEQETIAKEDLYNLNYITLDSQSTIRKVLDQVLTRCEINTSDLKIEMELNSIEAIKNAVQSGLGASFVSVTAIEKELKMGIIHRAYIDDVEIKRTLSVIVNSNRYRSKAAEAFIKEILPQFSSENHVSELDKLSKNNKQYLVIENDKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J1</accession>
    <name>K9Z1J1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">Cyan10605_0946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218807.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0946"/>
    <dbReference type="EnsemblBacteria" id="AFZ53076">
        <property type="protein sequence ID" value="AFZ53076"/>
        <property type="gene ID" value="Cyan10605_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0946"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.999"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_3_3"/>
    <dbReference type="OMA" id="RCQRVQY"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="11478" checksum="BD5D69CF7A1366C2" modified="2013-03-06" version="1">MIKLWLICYDVKDDKRRTQLAKLLEQHCERVQYSVFECPLDVKKLEHLLSTRWLKVLNLQEDSLRIYPLDASAKQKIKIYGLKDNPPYESPDYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J8</accession>
    <name>K9Z1J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217950.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0057"/>
    <dbReference type="EnsemblBacteria" id="AFZ52218">
        <property type="protein sequence ID" value="AFZ52218"/>
        <property type="gene ID" value="Cyan10605_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0057"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.59"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021719_0_0_3"/>
    <dbReference type="OMA" id="MELLYYY"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="499" mass="56217" checksum="27EEB242EFE3EC4E" modified="2013-03-06" version="1">MDRNKKIIVIGAGWAGLGATYHLVKQGFDVTLLEASSHAGGLVAGWKTAQGKSVEAGIHGFWYPYRNIFHLVKELNLEPFTAFTQSNQYSPYGLETTSPIFQNQPYLPSPLGTFVYPQFHRLPLCDRISALPLMYAVIDFDNSEEAWRRYDKITARELFRQYGVSSRLYHESFEPMLLVGLFAPGEQCSAAAALGMLYYFILAHQPDFDVVWCRGTVGEKIFQPWIEEIEKLGGKVVTNQRVTDILVDERGLATGVVCSDNVYEADSIISGVSVSGIKKIVSSSKSLNRYQQFRNLNNLGGIDVLAVRLWFDKKVNIPQPSNACFGFDRTTGWTFFDLNALHDQYQGEKGSVVEVDFYHANQFLSMTDDAIVERVHQYLKTCLPEFAMAEIIDSSVIRIPQGVTHFAPGSYQHLLKVQTAIPNLFMSGDWIITNHGSWSQEKAYVTGLEAANKVIEYFHQGKQADIIPVQKDEPHIEIARIINKNLRQVTEGFFPNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M0</accession>
    <name>K9Z1M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218207.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0328"/>
    <dbReference type="EnsemblBacteria" id="AFZ52475">
        <property type="protein sequence ID" value="AFZ52475"/>
        <property type="gene ID" value="Cyan10605_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0328"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068205_0_0_3"/>
    <dbReference type="OMA" id="HPKWREV"/>
    <dbReference type="OrthoDB" id="991310at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="36194" checksum="F30D5B4D69D9A3AE" modified="2013-03-06" version="1" precursor="true">MKRKSLRLIDSFPFLSGVLGITATVITSFSLFYPTVAQNVSTEIKIVAGDESGEYYAAAKDIEKLAQENNLDIDIIATKGALQNIDDVFRYNSVSLGLTQSDILAFYNTFANDNEEIRRKAESLRIVLPLYEEEVHLITRKDIKSVEDLEGKIVSIGDENSGTSTTATTLLFQWGVNPQELLTYDVKRSIDALRNGEIDAMFYVVGVPAKVLTEQILKEDNFQILPISLAINEDDDFFSRLYSPVTLPANTYEWQSEEVQTLAVQSLLFTVENDGCEQVSPVASLIKDNLSWLQANGSPIWKKVDLKLFHDETPERMSQCVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N1</accession>
    <name>K9Z1N1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superfamily I DNA and RNA helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218800.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0939"/>
    <dbReference type="EnsemblBacteria" id="AFZ53069">
        <property type="protein sequence ID" value="AFZ53069"/>
        <property type="gene ID" value="Cyan10605_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0939"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376185_0_0_3"/>
    <dbReference type="OrthoDB" id="393776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="23738" checksum="543EA33F1AC83F61" modified="2013-03-06" version="1">MISDSLISKYQIINRYKQLTGEALNKNNYLEILSLTELLKKLLTETYQGSDNQFVRSKQINFHLFKEKFSTQYNLEEIDSKHLWQEIYYLLKGNATYSINEKGLIALEDYQQQIQNYSFLPLNVNHQKIYKLAEKYQQWLKENNYWDDNDLSRYLLTHLHEDNIGKYYIYGDNIHHWSEISLKLICQLTTAEKTFALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N9</accession>
    <name>K9Z1N9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218226.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0348"/>
    <dbReference type="EnsemblBacteria" id="AFZ52495">
        <property type="protein sequence ID" value="AFZ52495"/>
        <property type="gene ID" value="Cyan10605_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0348"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.364"/>
    <dbReference type="eggNOG" id="ENOG50330B3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151356_1_0_3"/>
    <dbReference type="OMA" id="METEGGW"/>
    <dbReference type="OrthoDB" id="1987811at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12802" checksum="4A94A68B6817800B" modified="2013-03-06" version="1">MNSDYNYSAIEPKIKELVKQIWDIAEESQENLFAVLFILRELETLHRNIQQQMFEPALPDTRHRLYLLLRHLEEVGGWPYIERMRLRDICAKLILSENNSTQTTEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q3</accession>
    <name>K9Z1Q3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="12">DHBP synthase</shortName>
                <ecNumber evidence="12">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="12">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">ribBA</name>
        <name evidence="14" type="ordered locus">Cyan10605_0131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="12"/>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218020.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0131"/>
    <dbReference type="EnsemblBacteria" id="AFZ52288">
        <property type="protein sequence ID" value="AFZ52288"/>
        <property type="gene ID" value="Cyan10605_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0131"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.133"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_0_1_3"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="219"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="12">
        <location>
            <begin position="209"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="555" mass="62245" checksum="CF17C09071C15ED5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S4</accession>
    <name>K9Z1S4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-terminal processing peptidase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218840.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0979"/>
    <dbReference type="MEROPS" id="S41.010"/>
    <dbReference type="EnsemblBacteria" id="AFZ53109">
        <property type="protein sequence ID" value="AFZ53109"/>
        <property type="gene ID" value="Cyan10605_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0979"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1033"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_0_0_3"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938581" evidence="4">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="421" mass="46391" checksum="28C1F78100CCC031" modified="2013-03-06" version="1" precursor="true">MKITKRRLILGTTALAVSSVAMTGIGLRVSQSQAFFEDSPKEIVDEVWQVINRQYVDATFNGEDWRGIRQEYLDKEYSDKEEAYEAVKEMLKKLNDPYTRFMNPEEFKSMQIDTSGELTGVGIQITKEEETNNIVVISPIEDTPAAEAGIISKDIIRKVDGKSTEGMDLNDVVSLIRGKPGTQVKLTIEREGNIRDYNLTRAKIEIHPVRARIENTPNLGKIGYIRLVQFSGNAVQEMKDAIELGEKENVNGYILDLRSNPGGLLYSSVEIARMFIDKGQIVSTVDRVGQVDAHNANGSVLTNKPIVVLVDGGSASASEILSGALQDYDRATVVGTQTFGKGLVQSVRGLGDGSGLAVTIAKYLTPKGRDINKEGIVPDVVYEMTDAEKEVLIQDRDKIGTTEDAQYRKALEILSQQVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W2</accession>
    <name>K9Z1W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218428.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0556"/>
    <dbReference type="EnsemblBacteria" id="AFZ52697">
        <property type="protein sequence ID" value="AFZ52697"/>
        <property type="gene ID" value="Cyan10605_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0556"/>
    <dbReference type="eggNOG" id="COG1923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185801_0_0_3"/>
    <dbReference type="OMA" id="HYDQPTI"/>
    <dbReference type="OrthoDB" id="1985061at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="69" mass="7963" checksum="4C67F8B62F2CF46B" modified="2013-03-06" version="1">MTAFDTGFPSVRQIQSFIKNKTPIEIGLMTNKTLEGVVKWQDQNCLSLVTTSQEKILVWIQAIAYIRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y1</accession>
    <name>K9Z1Y1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218917.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1062"/>
    <dbReference type="EnsemblBacteria" id="AFZ53186">
        <property type="protein sequence ID" value="AFZ53186"/>
        <property type="gene ID" value="Cyan10605_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1062"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060279_0_0_3"/>
    <dbReference type="OMA" id="INGTHKQ"/>
    <dbReference type="OrthoDB" id="1239216at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938583" evidence="6">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="43104" checksum="2AD37CB686223E5C" modified="2013-03-06" version="1" precursor="true">MFIKKSFAFLCLCFFLVSCQGNSQPPQEVNDNEANREVEQGLVLYNSTIEQSNADGNTLWRISTEKAIYAQDNQSAKIEEIVGNLFENNEIILKVKADRGEVTKEGKEIFLEGNILVIDPRNKAEFRGEEVVWKPEDNFLVVTGKDKIKASHEKLVVTAKEGIYNTKNQVLELSKDVFATTNKPTLQLTTEHLYWRIPQDKVIGNKPLNMIRFDEKIITDKLNSQQVEVDLNNSVAVISGNVEYQSIKPSLQAATNRVVWYYGDRIMESNQPTKLIQPDKGTTLTANFVKFNLEENQVYLQEGIYGETKDKESEIYADKMLWNVDNEEINAEGNVYYSQLNPDLNLKGIKAWGNLRDKNITVQGDNSTRVITNIYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z228</accession>
    <name>K9Z228_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218180.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0300"/>
    <dbReference type="EnsemblBacteria" id="AFZ52448">
        <property type="protein sequence ID" value="AFZ52448"/>
        <property type="gene ID" value="Cyan10605_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0300"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.312"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298045_0_0_3"/>
    <dbReference type="OrthoDB" id="36006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="622"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="988" mass="117151" checksum="1F28450B3E8E6EE7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z266</accession>
    <name>K9Z266_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219020.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1170"/>
    <dbReference type="EnsemblBacteria" id="AFZ53291">
        <property type="protein sequence ID" value="AFZ53291"/>
        <property type="gene ID" value="Cyan10605_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1170"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1236"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009886_0_0_3"/>
    <dbReference type="OMA" id="TMWARPL"/>
    <dbReference type="OrthoDB" id="1523175at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1102" mass="125864" checksum="3F7ED8020199FED5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z281</accession>
    <name>K9Z281_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219035.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1186"/>
    <dbReference type="EnsemblBacteria" id="AFZ53306">
        <property type="protein sequence ID" value="AFZ53306"/>
        <property type="gene ID" value="Cyan10605_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1186"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2286853_0_0_3"/>
    <dbReference type="OMA" id="VIASQEH"/>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="9855" checksum="2DE4EB841A6C9923" modified="2013-03-06" version="1">MKLKDFYKTFKSDLMTDKEFVIGYLEEGGVSLFISALRDVVIASQEHLNNQLFNDLLNNDNPEMSLIFEVLNLLGLTINLKVKCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z292</accession>
    <name>K9Z292_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218406.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0533"/>
    <dbReference type="EnsemblBacteria" id="AFZ52675">
        <property type="protein sequence ID" value="AFZ52675"/>
        <property type="gene ID" value="Cyan10605_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0533"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.564"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_1_0_3"/>
    <dbReference type="OMA" id="EMADCNR"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="58"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="38444" checksum="5A82074535841EB4" modified="2013-03-06" version="1" precursor="true">MFNINVLTTVKKIGIPLGIVGLISACGSQSSQENQTILIDGSSTVYPVTEAIASNFNQKENAPVEVKVGLSGSIGGFEKFCQGETDINNASVPIPQRFMEECKKNNIAYIELPIAFDALTVVIHPSNDWANTMTVEELKTLWQPSAENKIENWSQINSQWPDKTVNLFGPGRDSGTFEFFTSAIVGAEDSSRNDYVFSENDEALVQGVIQDPNALGYFGFAYYKQHQDKLKAVAIDNGNGGILPSDETIKNNTYRPLTRPLFIYINAKKAQENPALQKFVKFYLAEAQNVVETVGYLPLPESAYNLALIHFEKNHVGTVFNGKPVLNASIDELLTKTYASEDKEGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z297</accession>
    <name>K9Z297_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218411.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0539"/>
    <dbReference type="EnsemblBacteria" id="AFZ52680">
        <property type="protein sequence ID" value="AFZ52680"/>
        <property type="gene ID" value="Cyan10605_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0539"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_2_3"/>
    <dbReference type="OMA" id="KDIWTSP"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="402" mass="45631" checksum="5F23CCF254EF4C44" modified="2013-03-06" version="1">MKIAYLINQYPKVSHSFIRREIIALESLGVTIKRFSVRKIGDELVDDEDKEELLKTRFILELGIKGLLFYLLRVILFQPLNFIKALILTFKIGYRSERGVMVNLIYLVEACVLSFWLKQEQIRHIHAHFGTNSTTVAMLTSLLGNISYSFTIHGPEEFDKPDAIALSEKIKRATFVVTISNYGKSQVYRWCEYQDWQKVHVIHCGLDEKFIQAEITPIPSENNLVCVGRLCPQKGQLLLLDAIARLKQKGIICQLTLVGDGELRQEIEKLAEKLHIKSQINITGWASSEEVKMKINEAKLMVIPSFAEGLPVVIMESFALGRPVISTYVAGIPELVVENESGWLCFAGDVESLTEKLEKALSLSPEKLNQIGIISKKKVKYNHDIEIEAKKLKNLFEIVVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A3</accession>
    <name>K9Z2A3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218416.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0544"/>
    <dbReference type="EnsemblBacteria" id="AFZ52685">
        <property type="protein sequence ID" value="AFZ52685"/>
        <property type="gene ID" value="Cyan10605_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0544"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.575"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_3"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="35379" checksum="9843689BD0351B5F" modified="2013-03-06" version="1">MRILVTGGAGFVGSHLIDRLMEQGNEVLCLDNFYTGTKANIQKWFNNPYFELIRHDITEPIRLEVDQIYHLACPASPIHYQFNPVKTTKVNVMGTLNMLGLAKRVKARFLLASTSEVYGDPDVHPQPEEYRGNVNCIGLRSCYDEGKRVAETLAFDYYREHKLEIRVARIFNTYGPRMLENDGRVVSNFIAQALRGIPLTVYGDGSQTRSFCYVSDLVEGLMRLMNNDYVGPVNLGNPGEYTILELAKTIQEMVNPEAELVYKPLPEDDPKQRQPDITKAKQYLDWQPTIPLRDGLRMTIEDFRQRICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B1</accession>
    <name>K9Z2B1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="8"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218259.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0384"/>
    <dbReference type="EnsemblBacteria" id="AFZ52528">
        <property type="protein sequence ID" value="AFZ52528"/>
        <property type="gene ID" value="Cyan10605_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0384"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.406"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029435_0_0_3"/>
    <dbReference type="OMA" id="FNHETIN"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010802">
        <property type="entry name" value="DUF1400"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07176">
        <property type="entry name" value="DUF1400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1400" evidence="10">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="560" mass="63227" checksum="C437045EA69F2F13" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2F6</accession>
    <name>K9Z2F6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0606"/>
    <dbReference type="EnsemblBacteria" id="AFZ52745">
        <property type="protein sequence ID" value="AFZ52745"/>
        <property type="gene ID" value="Cyan10605_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0606"/>
    <dbReference type="HOGENOM" id="CLU_182859_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10931" checksum="B61455F877EC92B2" modified="2013-03-06" version="1">MSVQVRSINCSVELNHLVTGKEKSLAIPDDVKADNLLGWNPVCLITYNRDSWVKLNQAPNPYAEEEALLLCEKVPGVWVSWIPGHGEMLLDKSEFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J1</accession>
    <name>K9Z2J1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0456"/>
    <dbReference type="EnsemblBacteria" id="AFZ52598">
        <property type="protein sequence ID" value="AFZ52598"/>
        <property type="gene ID" value="Cyan10605_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0456"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.482"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_3"/>
    <dbReference type="OMA" id="SPLFFVW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="30"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="355" mass="38029" checksum="E469F4458FF258E0" modified="2013-03-06" version="1">MLTKLSSIINNLVMGFLPSPLSDPVAIFLVMMAVLLIAPLLFEKIKLPGIVGLIIAGIIIGPDGIGLLERDQTIELFGTVGLLFLMFMAGLETSLDDLKSNASKASIFGFATFIVPMILGTMAFTFLLGYDILPSILVASCFSSHTLLSLPIVIKRGIARTPAVTVTLGGTLIVNIVALLVLAVVVKADQGELSLGFWLFLIPALIIYTVAALWAVPVVGRWFFRRFGHDEGAEFTFVVATLFVVSYCAKLIEIEPIIGAFLAGIGIRPLIPSLSPLMNRIQFIGNTLFVPFFLISVGMLVNPKDIVSNPKSLMVSGVMIVVAIAAKYIPAWGIGKLFLPLPSSSNCQSPIPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K9</accession>
    <name>K9Z2K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo-dependent nitrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219165.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1321"/>
    <dbReference type="EnsemblBacteria" id="AFZ53436">
        <property type="protein sequence ID" value="AFZ53436"/>
        <property type="gene ID" value="Cyan10605_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1321"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1395"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156633_1_1_3"/>
    <dbReference type="OMA" id="FHPPNYK"/>
    <dbReference type="OrthoDB" id="1680519at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009717">
        <property type="entry name" value="Mo-dep_Nase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06967">
        <property type="entry name" value="Mo-nitro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mo-nitro_C" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="11291" checksum="60C4C30D5C4AAAC7" modified="2013-03-06" version="1">MLNFNLLILMRSPFNFIKERLENLEISTKETAEKIVNLIPNTCPFAREIRLFNRSIFKIPPLCKLNPFYEDLMMLRFRALSFLCEIGEDITPYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L2</accession>
    <name>K9Z2L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219118.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1273"/>
    <dbReference type="EnsemblBacteria" id="AFZ53389">
        <property type="protein sequence ID" value="AFZ53389"/>
        <property type="gene ID" value="Cyan10605_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1273"/>
    <dbReference type="HOGENOM" id="CLU_1871994_0_0_3"/>
    <dbReference type="OrthoDB" id="1550915at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="136" mass="15542" checksum="A9B7E6AB3CFFCDA1" modified="2013-03-06" version="1">MEINGIKPQELIKNKGFWLWAILSALITINLTIFWKMNNVAHVGMIGLYWLAVYSLLWERRKKIYFQQKLIPCIIGIALIAWTLFVSRSIPTEKESNLLSIAPFIFATGLALIASGFRGLKEFRGELLIIFFLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z360</accession>
    <name>K9Z360_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218529.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0660"/>
    <dbReference type="MEROPS" id="M48.021"/>
    <dbReference type="EnsemblBacteria" id="AFZ52798">
        <property type="protein sequence ID" value="AFZ52798"/>
        <property type="gene ID" value="Cyan10605_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0660"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052979_1_0_3"/>
    <dbReference type="OMA" id="PNAMCIG"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="64"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="288" mass="32342" checksum="A3A1B6EB27299C7D" modified="2013-03-06" version="1">MTVKLIGLKADHFRHPLDLEATNRLKQLPGLDLAIRGFLGGIAEDFFYLNNIASSIRISEKQLPDLHDLLISACEILDVEKPQLYIQQNPVPNAYTLAIRGQKPFIVIHTSLLDLLNPEEIKAVIAHELGHLKCEHGVYLSLANIMVLAAGLIPSWGTLVAQSLQSQLLQWVRCAEFSCDRSALLVVQKPEIVMSVLMKLAGGSPNLASKLNLSAFMEQVKDYRMMSNNELGRLLQETQTAQLTHPLPIIRAKEVEKWSNSPEYDQLLNQKRISYNSGSDRQGGWRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C3</accession>
    <name>K9Z3C3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="11" type="ordered locus">Cyan10605_1572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219408.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1572"/>
    <dbReference type="EnsemblBacteria" id="AFZ53681">
        <property type="protein sequence ID" value="AFZ53681"/>
        <property type="gene ID" value="Cyan10605_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1572"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1668"/>
    <dbReference type="eggNOG" id="COG0376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_3"/>
    <dbReference type="OMA" id="MILAGNC"/>
    <dbReference type="OrthoDB" id="49441at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="10">
        <location>
            <begin position="128"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)" evidence="8">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="720" mass="80690" checksum="85C4B4DA98425F90" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G0</accession>
    <name>K9Z3G0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218996.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1145"/>
    <dbReference type="EnsemblBacteria" id="AFZ53267">
        <property type="protein sequence ID" value="AFZ53267"/>
        <property type="gene ID" value="Cyan10605_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1145"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_3"/>
    <dbReference type="OMA" id="SWTDEAW"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="92" mass="11014" checksum="7EE866A68572E3D7" modified="2013-03-06" version="1">MSNKASNKAVIFDSQFRDDLRWWFRKDKKVSERILNLIEATILNPTEGIGKPEHLKYLPGSTWSRRITQEHRLVYQISSDKIIFLQCRYHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N2</accession>
    <name>K9Z3N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219461.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1627"/>
    <dbReference type="EnsemblBacteria" id="AFZ53734">
        <property type="protein sequence ID" value="AFZ53734"/>
        <property type="gene ID" value="Cyan10605_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1627"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_1_3"/>
    <dbReference type="OMA" id="WRGENFV"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="15411" checksum="E8365AEB91A41193" modified="2013-03-06" version="1" precursor="true">MKRRRFFSLTLFSFIFTTFLPVFHKVFAQETENNFYKLGSLTDLEENGFLLNENLEIGAVLVILKEDNSLIAIEPTCTHMGCLVEWNKQENLFICPCHNSKFQEDGKVVEGLAISDLPIYQVKIENNTVFVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Q7</accession>
    <name>K9Z3Q7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219563.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1733"/>
    <dbReference type="EnsemblBacteria" id="AFZ53836">
        <property type="protein sequence ID" value="AFZ53836"/>
        <property type="gene ID" value="Cyan10605_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1733"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1840"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_3"/>
    <dbReference type="OMA" id="HPMWRDG"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="241" mass="26919" checksum="0DF47F7BF120E37D" modified="2013-03-06" version="1">MDKITIVLVESHDLTRIGLINALKDFAHIKVIGEASKIQEGFNLIQEKNPDIVIIDLALFSTEEIEFIRQLKKFHSSEEKPLKLIVLMIESDEDSVLQAFALGADSYCLKNVSIDNLQQAIQVTHEGDSWIEPAIASIILEQAKKSYQKKTEDLNTKDIEKIEIEPLSPESQEIIDNSSLTDREMEVLELIVAGKNNAEIAEDLYISIGTVKTHVRSILAKLCVCDRTQAAVHALRSGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3Z9</accession>
    <name>K9Z3Z9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219024.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1174"/>
    <dbReference type="EnsemblBacteria" id="AFZ53295">
        <property type="protein sequence ID" value="AFZ53295"/>
        <property type="gene ID" value="Cyan10605_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1174"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773207_0_0_3"/>
    <dbReference type="OrthoDB" id="2115027at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="358" mass="41071" checksum="84DCCB34B0BCC716" modified="2013-03-06" version="1">MTNSESDIQEIIKYVQKLEKRVKKLESKDAIILKSVPKDIQPKPLKFSPEKLIDIYNDVPSILEEYVVEVSITAQSWRSHSEDKTIVEKSIGGNYWIILLENLDEKKYYLLPNQSKKLRISRLRSLHNMFKIQGEKDTNNDNYIIIKPALLNMIPSGKEWEIIEKGILYLGKTSPTQKLTAELEKLTENQETMPSSLQGLLNVLEKLNKNNNELKIKLNSLEKRIQKLEPEEIKWVELYHLEPEKFATLGGGNTKLKLTETTVNKLLQSSTKDIYLEADSLGQYLLKQGEKGLYLFPDPLGIFDKNSLILTRLANLFITHGEIPIASLGKDIKVIKPAKLKKINNNQWSLLESGEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z427</accession>
    <name>K9Z427_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219616.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53889">
        <property type="protein sequence ID" value="AFZ53889"/>
        <property type="gene ID" value="Cyan10605_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1787"/>
    <dbReference type="eggNOG" id="ENOG50314K1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633720_0_0_3"/>
    <dbReference type="OMA" id="TILNCQK"/>
    <dbReference type="OrthoDB" id="1987151at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="17653" checksum="F92C7ECA8C59C093" modified="2013-03-06" version="1" precursor="true">MKQKINKRYIYQQIFITLSLSIIPLNSVCAEPVIYDFTVNVTEGSLKDNTYDGFIIYDDETVTGAEEEMITVEDGLKVCMNFFNKNYDETKDSDYPQYPQLILKDGKPESLDFWLEPNPRRQWWNKNGWLVTVTQRPENSNLPVNCPNGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z459</accession>
    <name>K9Z459_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ53981">
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        <property type="gene ID" value="Cyan10605_1881"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="475" mass="52767" checksum="079E429F9A22B8AA" modified="2013-03-06" version="1">MFEKLTPPEVGSKIKFDNGQPIVPDDPIIPFIRGDGTGVDIWPATEKVINAAVEKAYGGKRKINWFKIYAGDEACEKYGTYQYLPEDTLTAIREYGIAIKGPLTTPVGGGIRSLNVALRQIFDLYACVRPCRYYEGTPSPHKSPEKLDVIVYRENTEDIYLGIEWKQGSEVGAKLISLLNEELIPATAEFKNKQIPLDAGIGIKPISKKGSQRLVRRAIQNALRLPKHKQMVTLVHKGNIMKYTEGAFRDWGYELATTEFRAECVTERESWILSNKEANPDISIEDNARQIEPGYDSLTPEKKETIKKEVESVLNTIWDTHGNGQWQDKIMINDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDNCAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMGWQEAADLIRNGISRAIASRQVTYDLARMMTPPVEPPLKCSEFAQAIIDNFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z466</accession>
    <name>K9Z466_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1252"/>
    <dbReference type="EnsemblBacteria" id="AFZ53370">
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        <property type="gene ID" value="Cyan10605_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1252"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1321"/>
    <dbReference type="eggNOG" id="ENOG5032RVN">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183612_0_0_3"/>
    <dbReference type="OMA" id="RHFQSIC"/>
    <dbReference type="OrthoDB" id="1945889at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="10270" checksum="895441EE9E344111" modified="2013-03-06" version="1">MLTDPFAIRYYQKLTDGMVDLWHRGSRYEELRIYMEGYLACLRQTNVIEGYLIHRLEEEAYRFLRDPSNFELMATQMQPETDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A1</accession>
    <name>K9Z4A1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1300"/>
    <dbReference type="EnsemblBacteria" id="AFZ53415">
        <property type="protein sequence ID" value="AFZ53415"/>
        <property type="gene ID" value="Cyan10605_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1300"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1373"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_1_1_3"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="381" mass="42134" checksum="700AF695359F3011" modified="2013-03-06" version="1">MNIVPRLIPFYQPDINTWSLEARLLRWLTFLWIALGLIILFSASYAVGIEDSGNGWYYFQRQFFWAVIGLILFKIIIQIPISYILKWSGWGYVACLFMIFLTVIGLGQNINGAQRWLSLGPIQIQPSELLKPFLILQGAIVFGGWKKLNWTVKGTWLGIFAFTLACILKQPNLSTTALCGMTLWLMALAGGVPYLQLMVTAMGGVLVAGLSVMVNPYQLRRITSFVDPWADARGDGYQLVQSLLAIGSGGEYGVGFGMSQQKLFYLPFQYTDFIFAVFAEEFGFIGCLLLILLLVSFTTISFLVAIRCHHPTKRLIAVGVMIILIGQSLINIGVNIGALPTTGLPFPFLSYGGSSVLSSLMLVALLIRVAIETNITEKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G0</accession>
    <name>K9Z4G0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218992.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1141"/>
    <dbReference type="EnsemblBacteria" id="AFZ53263">
        <property type="protein sequence ID" value="AFZ53263"/>
        <property type="gene ID" value="Cyan10605_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1141"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1208"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159373_0_0_3"/>
    <dbReference type="OMA" id="WGDMVLT"/>
    <dbReference type="OrthoDB" id="1509710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14778" checksum="8F51099F17397756" modified="2013-03-06" version="1">MGIREDVFYEGGPHVGDLIINILLAFTVICLPLTVGAIVRSIWLRYRITDRRISVTGGWMGRDRTDIIYSEIVRVVKVPRGLGFWGDIVVTLKDKSRLEMRALPRFREIYDYIAEKAADKTGKPIDAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I2</accession>
    <name>K9Z4I2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219224.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1382"/>
    <dbReference type="EnsemblBacteria" id="AFZ53495">
        <property type="protein sequence ID" value="AFZ53495"/>
        <property type="gene ID" value="Cyan10605_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1382"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_21_0_3"/>
    <dbReference type="OMA" id="DFSHSFY"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="60"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="60"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="389" mass="43919" checksum="5FD8CC50C430C80C" modified="2013-03-06" version="1" precursor="true">MFFSPKFLEQIFLKLVLFFLLFIEAGEAKGLTNKVVGQNSLVREINSSESQIIANSKRERLRVATKSFPPFAFEENGQFVGFSIDLWKEIANELDVDFNIYGEKTISDLLNSVTDGYTDVGVAGITITWAREKDIDFSHSFFESGLQILVPMETVYPWQFFFAFIFSPILWSTVAIIVVVIAIASHLIWWLERKNNPQMFPENYKDGIWEAFWWAVVTVVTVGYGDKTPTGKAGRIIATIWMFTGVLLISYFTASVSSILTVQRLDNNITTIQDLYNKSVGTVKGSTAAEFLASTKSYVVLFDSIEDAFLALDDGKIKAIVYDAPVLRYYSRSDGAGKVKIVGSVFERQSYGIALKSNSPYRESINQAILKLKEDGTYERIYQQWFGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M0</accession>
    <name>K9Z4M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-vinyl reductase 4VR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219814.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1995"/>
    <dbReference type="EnsemblBacteria" id="AFZ54089">
        <property type="protein sequence ID" value="AFZ54089"/>
        <property type="gene ID" value="Cyan10605_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1995"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2118"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106284_0_0_3"/>
    <dbReference type="OMA" id="WKTHGWG"/>
    <dbReference type="OrthoDB" id="1377842at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="223" mass="24899" checksum="1D5403429B10AE76" modified="2013-03-06" version="1">MISVADLVREKPLKGNYFAPSAYVQGDFELGLLETRLGSRLIALPEVFLQGVYEGLNEELGQASGLVLYNCGKWWGKSFYRRFLQEVSEYYETPLAQMEMVEFLSCLKQCWKTHGWGVIEFNFDYYSQGFIVVNTVNSPFAQAAPQGEGFACQPEAGILTSFFSQLTGEDLLALQTSCESMGASANYFIIGLNERMKSAKAWLEEGHDHEMVINLLCSGSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N9</accession>
    <name>K9Z4N9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ordered locus">Cyan10605_1573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219409.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1573"/>
    <dbReference type="EnsemblBacteria" id="AFZ53682">
        <property type="protein sequence ID" value="AFZ53682"/>
        <property type="gene ID" value="Cyan10605_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1573"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1670"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_3"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="365" mass="39874" checksum="ABA1651C2EF21BAD" modified="2013-03-06" version="1">MASIISVNLPENSYSIHINAGGLNNIGEKASHLAIGKKILVVSNPEIFDYYGQITIDSLQNQGFEVNYHLIPAGENYKNLESIAQIYDTALKCRLERNSTLMALGGGVVGDMTGFAAATWLRGINFVQIPTSLLAMVDASVGGKTGVNHPQGKNLIGAFYQPKLVLIDPSVLKTLPEREFRAGMAEVIKYGVIWDKNLFEALESAQSIDSLNNFDEALLNDILTRSCQAKADVVGQDEKESGIRAILNYGHTIGHAIESLTNYETFVHGEAVAIGMVAAGRVAVKMGLWTENEAHRQDELIAKTGLPTTIPHYLKVEEIIDHLQMDKKVKDGKVRFILPEAIGKVQICDRISSEILSETLSVLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V0</accession>
    <name>K9Z4V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FolC bifunctional protein</fullName>
            <ecNumber evidence="5">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219167.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1323"/>
    <dbReference type="EnsemblBacteria" id="AFZ53438">
        <property type="protein sequence ID" value="AFZ53438"/>
        <property type="gene ID" value="Cyan10605_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1323"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1397"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_3"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="43"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="416" mass="46152" checksum="42B802EF82473D8C" modified="2013-03-06" version="1">MGNQIEDLLQPFQRFGINLGLKRIKNLLALLDNPQEKVPIIHVAGTNGKGSVCAYLSSILTASGYKTGRYTSPHLVNWTERICLNEKPIEENILIAILEKIRSVINPNDPECPTQFEVITAAAWLFFANSEVDVAVMEVGLGGRLDATNVCDRTLVSIITSISREHWFILGDTLSKIATEKAGVIKEKCPVVVGSLPEEAVRVVKNRAEELNAPTIWVESAQKLSPNQAEYEGVNYPLALGGDIQLQNSAIAIATIKILQEKGWQIPTSAIEEGMKNTRWRGRIEWVKWQKRDLLIDGAHNVASAEVLRQYVDTLHKPTTWVMGMLNTKDHEGIFKQLLRPEDQLHLVPVPDHSTAEPEELAILAKTIQPQLKQVQTYGDLFTALDSVTNNQETATTSIVLCGSLYLLGYFLSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z503</accession>
    <name>K9Z503_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219222.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1380"/>
    <dbReference type="EnsemblBacteria" id="AFZ53493">
        <property type="protein sequence ID" value="AFZ53493"/>
        <property type="gene ID" value="Cyan10605_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1380"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1458"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_3"/>
    <dbReference type="OMA" id="TYGDPKR"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="254" mass="29725" checksum="AB3DD71E5B1BB8D2" modified="2013-03-06" version="1">MNKNQNYNSETEFFKNYDPSKFYRPSTSVDTVIFTVFDLALQVLLVKRGEYPFKNQWTLVGGFIDLENDQTLEDTAKRKLEEKTGVKTPYLEQCFTIGNKIRDPRGWSVTTVYFALLPSENIQLKTNSDDITSSSVSAVKWSPIKNNKIKESLAFDHNYILEKAIERLRNKVLYTSLPAYLMPEKFTLRDLQTVYEIILDRTLESKSFRRRIERANILEPTGETRQDVKRPAQLYRLKENIDTYFFLRNIEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z578</accession>
    <name>K9Z578_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220061.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2250"/>
    <dbReference type="EnsemblBacteria" id="AFZ54336">
        <property type="protein sequence ID" value="AFZ54336"/>
        <property type="gene ID" value="Cyan10605_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2250"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2391"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_2_3"/>
    <dbReference type="OMA" id="RIALRGW"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="103"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="408" mass="45947" checksum="84A4B599E501C89C" modified="2013-03-06" version="1">MKQPCKIAYILKRYPRYSETFIVNEILAHESAGFAIDIFALRPPSDTHFQNIISQVRASVTYIQKPTQGRKSNFLNTLSPTPASYFWAELQETAQIIPDIWRKLPLATGERASVVYQALWLAREVRQRNITHLHAHFASVATSVTRLTSHFTNIPYTFTAHAKDIYHQSVDFNDLQNKIKDSKIVVTVSDYNRQYLQENYGKVAQSVKRIYNGIDLAKFTYLSPENRPPKIISVGRLVEKKGLSILIKACDLLKQWGCHFSCQIVGGGELETSLKNQIEELNLSDKVILIGSRPQNEVCELVQNSAVFAAPYIIAKDGNRDGLPTVLLEAMALGTPCIGTNITGIPELIRDGKTGLIVPQEDEKALAEALKQLLYKSDLRVKLAQSARHLLESEFDIHKNTALLRNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z584</accession>
    <name>K9Z584_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220029.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2218"/>
    <dbReference type="EnsemblBacteria" id="AFZ54304">
        <property type="protein sequence ID" value="AFZ54304"/>
        <property type="gene ID" value="Cyan10605_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2218"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2357"/>
    <dbReference type="eggNOG" id="COG2888">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677583_0_0_3"/>
    <dbReference type="OMA" id="FWYPSIQ"/>
    <dbReference type="OrthoDB" id="1772978at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="47476" checksum="7D8CF01B23DA7D19" modified="2013-03-06" version="1">MWNRIRDFIRVFFAKSRKIEDEPINKVSLIVIIIIDLFILGNVFYGLDDISRWPLSPTQAYPCYQSWQNYQEDSSSPDNYQFIRDFIGENQNSLSFNSVEENHLGKMSPLCLQYESLTQALNSNTNQNIVRRIDEKNTQIRLLEDKNKQIRQQYDSTLLEEIAGQPRELSINEIEAKTAKEELTNNQSNINLLTGEIKTLKGELLNKNESVALLNFVNSQDKFSQIKSSWERANFWYPTIQLLWQMVFLVPLIIISSLVHKWSDNKGYGLVSLMSWHLLVIFFIPLLIKLFEFLQIGFIFESLFNIVTILFGGLLFLVSYLYIFIIPLVGFLLINFFQKFVFNPYTQASKRVEKSRCLRCGKKINHDTAYCPHCGFYQYQECSNCHNLTYKYLSYCYHCGTKQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z594</accession>
    <name>K9Z594_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219447.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1613"/>
    <dbReference type="EnsemblBacteria" id="AFZ53720">
        <property type="protein sequence ID" value="AFZ53720"/>
        <property type="gene ID" value="Cyan10605_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1613"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1714"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040990_0_0_3"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="267" mass="31029" checksum="C2158FC7A3CAD4B4" modified="2013-03-06" version="1">MKINWFSPLPPANSDITNYTIKLLTFLQEKAEITFWTNQSPWDAKLKTEVAVKEYKIEQISWLELNQGDVNIYHIGNNAELYGDIWQISRRFPGIVILHDEKLQDFFYMLSSSKNEYIEYMKQCYGEEGNKNARLFLNNYHSREFMAKNYPLTPLALENALGVITYNYNNYLTLSAQNRIFVGYMPSLTNFINTDNNINSNPLSDADALINFASQVCQYRCQSSLERIVNRIVPELTYLNPKIETLNNFENLVDAIEFITLPVHSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D0</accession>
    <name>K9Z5D0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220115.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2307"/>
    <dbReference type="EnsemblBacteria" id="AFZ54391">
        <property type="protein sequence ID" value="AFZ54391"/>
        <property type="gene ID" value="Cyan10605_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2307"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2451"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_3"/>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="460" mass="51264" checksum="7763B600BEEC24F7" modified="2013-03-06" version="1">MLTSNYSIASLLDKQRQYFATGETKSVDFRLQQLKKLKSAIASRQDKILEALKADLGKPTFEGCFELAVLQDLTYAIKNLKKWVKPQKVKTGLELFPAQAKIHPEPLGVVLIIGPWNYPFSLMISPLIGAIASGNCVLLKPSEIAPHTSALLTELIRDTFPSEYICIQEGGVEVAQELLACKFDHIFFTGGTKIGQIVMEAAAKHLTPVTLELGGKSPCIVDTQINLTETAKRITWGKFINAGQTCIAPDYILVDEKIKADLIKEMKKCVESYFGDNPADSPDFARIINHKQFDRLQNLLTDGKIIIGGNYNREEKYIAPTILDEISPDSPIMQEEIFGPILPVLSYQTLEDAIAFVNSKPKPLALYFFSHNKDKQQKILRETTSGGLCFNETIMHVGVTELPFGGVGDSGIGAYHGKATFDTFSHHKSVLSRPFWGDLNWRFAPYSEKNVKLFKQIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D7</accession>
    <name>K9Z5D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein HSR1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219684.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1856"/>
    <dbReference type="EnsemblBacteria" id="AFZ53957">
        <property type="protein sequence ID" value="AFZ53957"/>
        <property type="gene ID" value="Cyan10605_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1856"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466061_0_0_3"/>
    <dbReference type="OMA" id="INREMEY"/>
    <dbReference type="OrthoDB" id="764091at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040576">
        <property type="entry name" value="DLP_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18709">
        <property type="entry name" value="DLP_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="54"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DLP_helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="548" mass="63175" checksum="9560D7CF8FF3F8CD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I8</accession>
    <name>K9Z5I8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="4" type="ordered locus">Cyan10605_2325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220133.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2325"/>
    <dbReference type="EnsemblBacteria" id="AFZ54409">
        <property type="protein sequence ID" value="AFZ54409"/>
        <property type="gene ID" value="Cyan10605_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2325"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2469"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022481_1_0_3"/>
    <dbReference type="OMA" id="SKPGFVI"/>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="3">
        <location>
            <begin position="454"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="568" mass="66173" checksum="2E7245BBF6BF2C4C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K0</accession>
    <name>K9Z5K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase/phosphodiesterase with PAS/PAC and periplasmic sensors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219567.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1737"/>
    <dbReference type="EnsemblBacteria" id="AFZ53840">
        <property type="protein sequence ID" value="AFZ53840"/>
        <property type="gene ID" value="Cyan10605_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1737"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1844"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_36_3"/>
    <dbReference type="OMA" id="YIWFETL"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
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        <location>
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        </location>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1118" mass="129413" checksum="DECCD3DDACE1B9EA" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L8</accession>
    <name>K9Z5L8_CYAAP</name>
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            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1941"/>
    <dbReference type="EnsemblBacteria" id="AFZ54037">
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        <property type="gene ID" value="Cyan10605_1941"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="15852" checksum="C523A551F8687141" modified="2013-03-06" version="1" precursor="true">MVNTNKKTTPKQIFRRVLVILSGLSFFSFSIFGVVKMLKSPSNANQPQQQETDSAQAILEKEAQGYKLVLQREPDNIFALEKLVQIYLSGGDLASALPLMEKLVSLQPENQSYQEALSFIKQGLAQQNNPSTNTPNPPSQSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q0</accession>
    <name>K9Z5Q0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_1590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Geminocystaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFZ53698">
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        <property type="gene ID" value="Cyan10605_1590"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <begin position="231"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="328" mass="38373" checksum="619E560261030013" modified="2013-03-06" version="1">MIALSTVNWSNYWQQESESFTTFSGEKEEVWREKGLLGYSEEKYIPLRRDLYLEISDYHMYEDVMLTSQYDQKNDEHFVINFVVSGNVKTIYHGVTDYVSETAGKNYIEFWESRQETEYWQKGDRILKVRVGISLSTLREMCEDSLDTLPSELQLLITGKNVPPCYRQGENNINMNSALNQIVNCPYQGFTRNFYLESKALELLALWLGKNNKIGFNQISSLSRKDIIALQEVKNIMKKNLQNPPSLKELSRQLCINECKLKSGFKKLFNTTIFNYLHRQRMEYAHSLLRDKKIKITDVAMMCGYASLPSFSKAFKKYYGISPRCDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q2</accession>
    <name>K9Z5Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2397</name>
        <name evidence="2" type="ordered locus">Cyan10605_2885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2397"/>
    <dbReference type="EnsemblBacteria" id="AFZ54479">
        <property type="protein sequence ID" value="AFZ54479"/>
        <property type="gene ID" value="Cyan10605_2397"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54951">
        <property type="protein sequence ID" value="AFZ54951"/>
        <property type="gene ID" value="Cyan10605_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2397"/>
    <dbReference type="KEGG" id="can:Cyan10605_2885"/>
    <dbReference type="HOGENOM" id="CLU_3182719_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="46" mass="5414" checksum="BBADF25F5A26F63E" modified="2013-03-06" version="1">MKFHLSSIIQIFFVRFNRLFPSHKIEAFEAIMILAISHAYGCFNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S1</accession>
    <name>K9Z5S1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219647.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1818"/>
    <dbReference type="EnsemblBacteria" id="AFZ53920">
        <property type="protein sequence ID" value="AFZ53920"/>
        <property type="gene ID" value="Cyan10605_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1818"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1929"/>
    <dbReference type="eggNOG" id="ENOG5031WDP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111088_0_0_3"/>
    <dbReference type="OMA" id="YIPLDPF"/>
    <dbReference type="OrthoDB" id="1415617at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022203">
        <property type="entry name" value="DUF3727"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12527">
        <property type="entry name" value="DUF3727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22269" checksum="17C708C267EC39B8" modified="2013-03-06" version="1">MSSPGFSSDSGQYDDTEIVTIFDDEGRSLDCYIENEIEYDGKIYVLLMPIDLAIVILTEEIDSEDNEYSETVMVEDKEELDGIFDDAKAVLGELNLYLKRTGFILTASGELPPLEENNIISLEIEEHTSEIEPEELQFLASFYSEEQKYNICTPLSPILFIGEKDGFGKINIIQSQEEEVSWILEELLFEDYEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X0</accession>
    <name>K9Z5X0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase I beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220309.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2505"/>
    <dbReference type="EnsemblBacteria" id="AFZ54586">
        <property type="protein sequence ID" value="AFZ54586"/>
        <property type="gene ID" value="Cyan10605_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2505"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2655"/>
    <dbReference type="eggNOG" id="COG3968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024307_0_0_3"/>
    <dbReference type="OMA" id="QFLVFCA"/>
    <dbReference type="OrthoDB" id="179916at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="192"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="724" mass="80316" checksum="568098DADA38DB89" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y5</accession>
    <name>K9Z5Y5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">Cyan10605_1886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219710.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1886"/>
    <dbReference type="EnsemblBacteria" id="AFZ53985">
        <property type="protein sequence ID" value="AFZ53985"/>
        <property type="gene ID" value="Cyan10605_1886"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1886"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2002"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_3"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="152" mass="17777" checksum="FA23E59B61BE26CE" modified="2013-03-06" version="1">MSDKVKIISDNRQARYLYEILETYEAGVQLVGTEVKSIRAGRVNLRDGYALIRNGEAWLTNVHISPYDTTGKYFNHEPKRDRKLLLHKKEINKLIGALQEKGLTLVPLKMYLRGEWVKVSLGLGKGKKLHDKRETIKRREDQREMQRALKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A9</accession>
    <name>K9Z6A9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219670.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1841"/>
    <dbReference type="EnsemblBacteria" id="AFZ53943">
        <property type="protein sequence ID" value="AFZ53943"/>
        <property type="gene ID" value="Cyan10605_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1841"/>
    <dbReference type="eggNOG" id="ENOG5033INN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2664991_0_0_3"/>
    <dbReference type="OMA" id="GRNAQTR"/>
    <dbReference type="OrthoDB" id="2071758at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8523" checksum="34B4B1BF7ACD4A05" modified="2013-03-06" version="1">MNTKTFKISLTFEDILNLAKQLSNSEQNILIKELQKNIITDEKDSLIDVCERIGRNAQTRGLTEEKLADLLADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B1</accession>
    <name>K9Z6B1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-threonine-O-3-phosphate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2191"/>
    <dbReference type="EnsemblBacteria" id="AFZ54277">
        <property type="protein sequence ID" value="AFZ54277"/>
        <property type="gene ID" value="Cyan10605_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2191"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2328"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_3"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="11">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="39362" checksum="2AEC09589B5C8E73" modified="2013-03-06" version="1">MNHETATQVVDFSASINPLGPPQSAIASLKAGIVELNHYPNPDYPQFRLGVANHHHLDEKYILPSNGAAELLTWIAWECHELEGVLLPSPCFADYKRALKTFGVKYQFYPLDDLDKGINSPQSSRLAILINNPHNPTGKLWTRLSLQPYLEKFALVIVDEAFMDFLPPQNQESLIDFIKDYDNLVILRSLTKFYSLPGLRIGYGISNPQTIAKWQKWRDPWSVNSLAEIAAVACLQDKAFQEKTWQWLPPTRESLKQGLDNIEFLQVLPSQSNFLLVKTQIPSTQLQLRLLRQKQILIRDCVSFPELGEKYFRVAVKTHIDNQKLLDELNKLSKAIVENQEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D1</accession>
    <name>K9Z6D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219860.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2046"/>
    <dbReference type="EnsemblBacteria" id="AFZ54135">
        <property type="protein sequence ID" value="AFZ54135"/>
        <property type="gene ID" value="Cyan10605_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2046"/>
    <dbReference type="eggNOG" id="ENOG50335HA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632248_0_0_3"/>
    <dbReference type="OrthoDB" id="2025335at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9270" checksum="0F1C612A8BA9B293" modified="2013-03-06" version="1">MKMIQVKGEIKQGELKIKTPLEMSDGEVDLIIFKQSQEAEEFQTMRQLAKENGYDSREKIMDLIHQVKLEMLEEKGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6I0</accession>
    <name>K9Z6I0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220076.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2267"/>
    <dbReference type="EnsemblBacteria" id="AFZ54352">
        <property type="protein sequence ID" value="AFZ54352"/>
        <property type="gene ID" value="Cyan10605_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2267"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2408"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_3"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="389" mass="42513" checksum="B5C8CBC105B6C861" modified="2013-03-06" version="1">MTQLADRISQVTPSITLTISAKAKAMKAEGLDVCSFSAGEPNFDTPNHIKEAAKKALDEGKTRYGAAAGELALRNAIASKLQRDNNLNYQAENVIVTNGGKHALFNLIFALIEPEDEVIIPVPYWLSYPEMVTLAGGKSIFVTTSAENNYKITPEQLESAITPKTKLLILNSPSNPTGAVYTPEEIHSLAEIVIKHDILVVSDEIYEKILYEGATHLSIGAVSEEVFKRTIVCNGFAKAYSMTGWRVGYIAGSVDIIKGMTTIQSHTTSNVCTFAQYGAIAALESSQDCVKEMLEAFTERRKFMYSAIQSIQGISCPLPYGAFYLFVDISSTGLKSLEFCEKLLQQEKVAAIPGIAFGDDNCIRLSYATDMTTIEKGINRLNNFIQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K4</accession>
    <name>K9Z6K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220544.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2752"/>
    <dbReference type="EnsemblBacteria" id="AFZ54821">
        <property type="protein sequence ID" value="AFZ54821"/>
        <property type="gene ID" value="Cyan10605_2752"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2752"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2922"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_3"/>
    <dbReference type="OMA" id="SHPWFEV"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="207"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="449" mass="51084" checksum="4BFC984EF2DB0503" modified="2013-03-06" version="1">MFQATRRRLAIWYTTITAILLIIFATGIYGYVYKTLLDRIDDTLKHVIEIVEPSLVIEEIAAAEGKYRVNLDKSFYQHPHATNQVEDDHIDLEWFSPNGELLWETLEKPLPIPLSFHSGGKTIRISDDYLLRQITKRIEKGRYVLGYLRVSHPLFDVVKPIQQLIVDLSLGIILLIISVGAIGWFLSGIAIQPVKDSYQSLKQFTADASHELRNPLATIKTNIQSLLSYPDIDINTQQKQLKILDRLTERLNNLVNDLLFLARNDSGIVNYNFGEIPLDGLLLEVIEEQKIIAHNQNIDLLFDILDSDINWQELNNEPYTIIGDWTQLNRLFTNLISNGIIHGKGDKHLSEKLVIKVLLSSYKKHHKIYYQVEVKDNGVGIKESMLSHLFERFYRGDSARSNNSFGNSSTGLGLAIALAIVENHQGKIKVESKENEGCNFIVTIPSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M0</accession>
    <name>K9Z6M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LL-diaminopimelate aminotransferase apoenzyme</fullName>
            <ecNumber evidence="3">2.6.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.83" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219920.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2106"/>
    <dbReference type="EnsemblBacteria" id="AFZ54195">
        <property type="protein sequence ID" value="AFZ54195"/>
        <property type="gene ID" value="Cyan10605_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2106"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2239"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_3"/>
    <dbReference type="OMA" id="NDECYSE"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="393" mass="43911" checksum="7A2275857474E05C" modified="2013-03-06" version="1" precursor="true">MKTSWINRANRLSALPPYVFARLDELKAKAREQGLDLIDLGMGNPDGFAPTPVIEAAKEALNVAKYHGYPPFEGTANFRNAIASWYQRRYQVELNPDSEALPLLGSKEGLSHLALAYVNPGDTVIVPSPSYPAHYRGPAIAGADIYALKLSAENDWLIDLTQIPEDIARKTKILYFNYPNNPTTATAPRAFFEEVVSWAKHYEVMLVHDLAYAELAFEGYEPTSLLQIKGAKEIGVEFHTLSKTYNMAGWRVGFVVGNSDIIQGLRTLKTNLDYGIFSVIQAAAQTALQLPDSYIHEVQQRYQKRRDFLIEGLNKMGWNVKPSSATMYLWIPVPRNSNSTDFALDLLQKTGVVVTPGNAFGDGGEGYVRVSLIADCDRLMEALQRWEKANIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U1</accession>
    <name>K9Z6U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer with GAF sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220186.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2379"/>
    <dbReference type="EnsemblBacteria" id="AFZ54462">
        <property type="protein sequence ID" value="AFZ54462"/>
        <property type="gene ID" value="Cyan10605_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2379"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2526"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_2_3"/>
    <dbReference type="OMA" id="TVWEDTH"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="454"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="626"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="788"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="844"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123391" checksum="B53CC0848687252B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V6</accession>
    <name>K9Z6V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220596.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2807"/>
    <dbReference type="EnsemblBacteria" id="AFZ54874">
        <property type="protein sequence ID" value="AFZ54874"/>
        <property type="gene ID" value="Cyan10605_2807"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2807"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2984"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_3"/>
    <dbReference type="OMA" id="WRAMAGM"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13442" checksum="1EB7F4230CF41C12" modified="2013-03-06" version="1">MNYDLSYLLDIAHLCQTILRLTNNMTREEFFNDERTYLAVLYEITVIGEVVKRLSPGFRENHPQIQWRQIAGMRDRLVHDYDEVKLDLVWQVVINYIPELLTYITPLLPSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z714</accession>
    <name>K9Z714_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ordered locus">Cyan10605_2451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220255.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2451"/>
    <dbReference type="EnsemblBacteria" id="AFZ54532">
        <property type="protein sequence ID" value="AFZ54532"/>
        <property type="gene ID" value="Cyan10605_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2451"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2596"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_3"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="22706" checksum="47ED6779C12E16CA" modified="2013-03-06" version="1">MTKIAVIDYDMGNLHSACKGLEKAGANPIITDSPQVIAQADGVVLPGVGSFDPAMQHLQQRDLVTPIQNFVKSGKPFLGICLGLQILFESSEEGKESGLGIIKGQVKRFQSEPDLTIPHMGWNNLDLIQANHPLWKNLPVSPYVYFVHSYFVSPRDSQVIAAQVTHGSQTVTAAIAFENIMAVQFHPEKSSDYGLQILTNFVDFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z720</accession>
    <name>K9Z720_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220715.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2934"/>
    <dbReference type="EnsemblBacteria" id="AFZ54996">
        <property type="protein sequence ID" value="AFZ54996"/>
        <property type="gene ID" value="Cyan10605_2934"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2934"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3122"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_2_0_3"/>
    <dbReference type="OMA" id="LYERIDH"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="18404" checksum="CE17149E28B49D83" modified="2013-03-06" version="1">MKGNKKVIKQLQKLLRSELAARDQYFTHSRMYDDWGLTKLYERIDHEMQDETHHADMLIKRMLFLETTPDLSEQEGLKIGKDVPEMLRNDLELEYKVIGDLKDAIAICEQEQDYQTRELLRVMLGDTEEDHAYWLEKQLGLIDKIGLQNYLQSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z745</accession>
    <name>K9Z745_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219913.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2099"/>
    <dbReference type="EnsemblBacteria" id="AFZ54188">
        <property type="protein sequence ID" value="AFZ54188"/>
        <property type="gene ID" value="Cyan10605_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2099"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2231"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374147_0_0_3"/>
    <dbReference type="OMA" id="EHHSMVS"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="383"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="727" mass="78904" checksum="CD480318D8E79F95" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z746</accession>
    <name>K9Z746_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyamine-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220688.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2907"/>
    <dbReference type="EnsemblBacteria" id="AFZ54969">
        <property type="protein sequence ID" value="AFZ54969"/>
        <property type="gene ID" value="Cyan10605_2907"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2907"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3094"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="FARAIMS"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="29198" checksum="88ED94D25E23F25F" modified="2013-03-06" version="1">MTAQEPLIELRGVSKAFGNKVILKDADLKIYEGDALVVIGPSGTGKSTILRLIAGFMQPDAGEIYIKGEKRVSLIDDGDYPIHISMVFQQAALFDSLSVRENVGFSLYQHSDLDYDYISQLVDRALEMVGLPPSTGNLFPAELSGGMRKRVSFARAVIYNPEKPFERPDVILYDEPTAGLDPIASTVVEDLVRTLKSSVCESCAYVMVSHQESTIRRTGDRLAFLYDGKIQWQGNVKDIDTTENPLVRQFFSANTQGPIKVISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z791</accession>
    <name>K9Z791_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220164.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54440">
        <property type="protein sequence ID" value="AFZ54440"/>
        <property type="gene ID" value="Cyan10605_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2356"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2502"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_4_0_3"/>
    <dbReference type="OMA" id="FASEMVI"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="42030" checksum="27EFA96DADB45619" modified="2013-03-06" version="1">METLELSIIMPCLNEAETLATCIEKAQWYLQEYQIQGEVLIADNGSTDGSQDIAKRMGARLVNVTEKGYGSALMGGIIAAKGEFIIMADADDSYDFRSLNPFVEKLREGYDLVMGNRFKGGIKPNAMPFLHKYLGNPVLTWLGKLFFKSPCNDFHCGLRGFRKRAIMSLNLRTTGMEFASEMVVKATLNGLKITEVPTTLSPDGRSRKPHLRTWRDGWRHLRFLLLYSPRWLFLYPGFFLMIMGLISTIILLASPRVHSLLYSATAIIIGFQLVNFAVFTKIYAIQEGLLPNDKRVLKFKDLFSLEIGLIIGSILFIAGLITSIFALFQWEAVGFGALNPVQTMRLVIPSVTAIALGLQIIFASFFLSVFQLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F4</accession>
    <name>K9Z7F4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ordered locus">Cyan10605_2592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220390.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2592"/>
    <dbReference type="EnsemblBacteria" id="AFZ54667">
        <property type="protein sequence ID" value="AFZ54667"/>
        <property type="gene ID" value="Cyan10605_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2592"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2753"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_3"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="490" mass="54169" checksum="B660EACA3429683A" modified="2013-03-06" version="1">MKDNQHNSSVNEHSILYGDKPEEACGVFGVYAPEETVAKLAYFGLYALQHRGQESAGIATFDNGSCYSYKDMGLVSQVFNESILANLQGQIAVGHTRYSTTGSSLKVNAQPAVVDTRLGKLALAHNGNLVNTLELRQELDRRNGQYVSTTDSEMIAIMIGKEVDTGKDWIEAAISSFKWCQGAYSLVIGTPDGIIGARDPHGVRPLVIGTIRQENNINRYVLASETCALDIIGAEYIRDVEPGELVWIDDNGLTSKKWTEASNPKLCVFEMIYFARPDSIMGHDSLYAYRLRLGEQLAKESLTDADIVMGVPDSGIPAAIGYSRHSGITYQEGLIKNRYVGRTFIQPTQHMREHGIRMKLNPLKDVLEGKRVIIIDDSIVRGTTSRKIVRALRDAGAIEVHMKISSPPVTHPCFYGIDTDSQDHLIAATKSVEEIARQIEVDSLTYLSEEGMLKVTSQNPQSFCTACFNGNYPIEIPENIKRSKLMLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L9</accession>
    <name>K9Z7L9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo-dependent nitrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2638"/>
    <dbReference type="EnsemblBacteria" id="AFZ54712">
        <property type="protein sequence ID" value="AFZ54712"/>
        <property type="gene ID" value="Cyan10605_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2638"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2802"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156633_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009717">
        <property type="entry name" value="Mo-dep_Nase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06967">
        <property type="entry name" value="Mo-nitro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mo-nitro_C" evidence="1">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13966" checksum="D031548FEBAD3CEA" modified="2013-03-06" version="1">MGVVDYLFSEIVLQNQISYSQDLSLKSRWHLPKFEFKWHKIDLLLPLRSWLDNIEITDSVTAHRINNLIPAECPFARKITIFNRTILTIPPLCKLNPVYDNLMALKFRCLTYLAEMEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R3</accession>
    <name>K9Z7R3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220490.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2694"/>
    <dbReference type="EnsemblBacteria" id="AFZ54767">
        <property type="protein sequence ID" value="AFZ54767"/>
        <property type="gene ID" value="Cyan10605_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2694"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2858"/>
    <dbReference type="eggNOG" id="ENOG5031XGJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097189_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="253" mass="29316" checksum="165D98303C3257B5" modified="2013-03-06" version="1">MTSSTFTHTGVIRQGDVLIIPLKKLSVKESVKLPNLTLAKGEVTGHSHRISDGKAELYERSGILFLRVLSPTAKLQHEEHHALNIPKGDWMVRIQREYRPIPPLDDSSNVTLSSKTTLSQKNTLIDSPDHPTEQKEEPLKDDLIDLANKVDFKYWNKLVEDAEKRKEYLEKIQTNKKKFNDEYADKIEEEKPKIRKHKIRYLEAKRESLNDYLTPYTPVKNVSLSHTQPSNWLDNLINHVMNSQRKNWTDVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T4</accession>
    <name>K9Z7T4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220368.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2565"/>
    <dbReference type="EnsemblBacteria" id="AFZ54645">
        <property type="protein sequence ID" value="AFZ54645"/>
        <property type="gene ID" value="Cyan10605_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2565"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908259_0_0_3"/>
    <dbReference type="OMA" id="ANFRINS"/>
    <dbReference type="OrthoDB" id="2139710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="35903" checksum="A260F3DEB4D33B23" modified="2013-03-06" version="1">MNELEEIYKKFHEINIKLKKLEKKADRIIVTGGKLNKQPKPINIRLEELINIYNYIPQILSEYATPVSLSAKTYREKIEEVELDYQHNGYYWVILLENQGIKNYYLLPNGNIKFNFARLQNYINFVFILHGNFLDIGNNFSLIRCATIDILPNGLSWILKAKGEIISKISPSDLLLKELLKFQDKDKQIPDNISKLLDLLDSYYNETLKIKDRLYIESENIIELEEKFVQLNDIFISNNRQVYSLIDVKEKSILERVIQMNEQLSDKIAQQDKQIRGLRSNIGCLNFLVFILVLFISFFLWVAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y9</accession>
    <name>K9Z7Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220574.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2785"/>
    <dbReference type="EnsemblBacteria" id="AFZ54852">
        <property type="protein sequence ID" value="AFZ54852"/>
        <property type="gene ID" value="Cyan10605_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2785"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2959"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_9_3"/>
    <dbReference type="OMA" id="HFPMLED"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="292" mass="33084" checksum="DDEB9FC6C8CDF45B" modified="2013-03-06" version="1">MNTSTAQTNLNEKGTVNIRGVNHYYEWIRTPSENNSPKPVMVFIHGWGGSCRYWRTTANAIASNYDCLLYDMRGFGQSKEEKGAKIGYELEDYAQDLLLLLDKFNLEKVYLNSHSMGASVGTIFLNLAPERIHKAILTCNGIFTYNALAFSAFHKVGGYVVKFRYHWFLKVPFAEKLFMARFLYQPIPKQMGIDFLEDFLLADYDAALNTIYSSVSKKAVEIMPQEFSKIQVPTLLVSGEKDQIIPASMGKAAVALNPEKISYFEVPKTGHFPMLEDSTTYLKAINKFLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z7</accession>
    <name>K9Z7Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221034.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3270"/>
    <dbReference type="EnsemblBacteria" id="AFZ55316">
        <property type="protein sequence ID" value="AFZ55316"/>
        <property type="gene ID" value="Cyan10605_3270"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3270"/>
    <dbReference type="eggNOG" id="ENOG502Z85V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000544_0_0_3"/>
    <dbReference type="OMA" id="FLEVGWL"/>
    <dbReference type="OrthoDB" id="1578772at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022017">
        <property type="entry name" value="DUF3598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33404">
        <property type="entry name" value="PTHR33404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12204">
        <property type="entry name" value="DUF3598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3598" evidence="1">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="268" mass="30882" checksum="8253F127540FD7B2" modified="2013-03-06" version="1">MSSSQWSYLLKNSGVWLGSFSQFSPHGKLLKETSSKLTLGSDDGKTIRFTLARDGNPNPVVNEFSSLNRNIFLFEDGHFAKGSQQFSPFSVFGAEYGYVRCDRRCRLVQLFDKDSNFDSVTLIREFREGGEGIEREHLTIEQLEGEWRGEALTLYPDWRNSEPYQTQLTLKREGNTLKQTLKTPFMNYSSEGTINDNIITFNQGNKENRVLLLPDGASSTTPVKIENRQSFFLEFGWLVETNMRLRLIRQYDDQGRWVSITLVREIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z842</accession>
    <name>K9Z842_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220624.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2835"/>
    <dbReference type="EnsemblBacteria" id="AFZ54902">
        <property type="protein sequence ID" value="AFZ54902"/>
        <property type="gene ID" value="Cyan10605_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2835"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3013"/>
    <dbReference type="eggNOG" id="ENOG5032S8F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165972_0_0_3"/>
    <dbReference type="OMA" id="WWAWSSD"/>
    <dbReference type="OrthoDB" id="1928635at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="80" mass="9802" checksum="813FBC4A8C549F71" modified="2013-03-06" version="1">MEAFTRNAPDWTKTATHAFDFCCPRCEASSREAKKVWLNRYAPVTMENYRRKWQEFYLCECEQVWWAWSNERPSFEDNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z852</accession>
    <name>K9Z852_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Condensin subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220286.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2482"/>
    <dbReference type="EnsemblBacteria" id="AFZ54563">
        <property type="protein sequence ID" value="AFZ54563"/>
        <property type="gene ID" value="Cyan10605_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2482"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2631"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_6_0_3"/>
    <dbReference type="OMA" id="YGFPEND"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="164" mass="18801" checksum="BA06D8EB4FD6C9EB" modified="2013-03-06" version="1">MDQKIFSPSLSQHIEAILYLKAQPTTLQEIVTLTNHSTEEVQEALIQLMSDYAYRNSALEIIETEQGYSLQLQSEYLSLLSNLVPAELNTATLKTLAAIALQSPILQSDLINLRGSTAYQHVSELVESGFIRKRRQEEGRSYWLEVTDKFHKYFEFNQAQTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z867</accession>
    <name>K9Z867_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220488.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2692"/>
    <dbReference type="EnsemblBacteria" id="AFZ54765">
        <property type="protein sequence ID" value="AFZ54765"/>
        <property type="gene ID" value="Cyan10605_2692"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2692"/>
    <dbReference type="eggNOG" id="ENOG50317CS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074695_2_0_3"/>
    <dbReference type="OMA" id="QVMWKYL"/>
    <dbReference type="OrthoDB" id="1729429at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021420">
        <property type="entry name" value="DUF3067"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35126">
        <property type="entry name" value="PTHR35126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11267">
        <property type="entry name" value="DUF3067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="12068" checksum="8C5DB41645017D90" modified="2013-03-06" version="1">MTGQELQQLIINKWGYSYDAQVVRIKDKIYFQVMWKYLEQASFHYTQAEYMANLEQIAQYLTSWGVVSQVIEGITDTKSKPRLGKAVSISLNLGERASEWILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K8</accession>
    <name>K9Z8K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221217.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3462"/>
    <dbReference type="EnsemblBacteria" id="AFZ55499">
        <property type="protein sequence ID" value="AFZ55499"/>
        <property type="gene ID" value="Cyan10605_3462"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3462"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_3"/>
    <dbReference type="OMA" id="FIHKPAS"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="191"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="328" mass="37292" checksum="FDEADDCDAD974C2F" modified="2013-03-06" version="1">MNYDVLIVDDIVNNIQLLKKIFATQGYHVRQANNGSHALEEIAKKKPDLILLDINMPGINGYQVCEIIKSNSITQEIPIIFLSGCDRSDDKIRAFNLGGADYITKPFYPEEVLIRTKNQLTIQEQKKQLINQNLSLQKEIEKRKKAEASLRQANKKLEELAIIDDLTKVSNRRHFNQYLSQQWQQMKREQKPLSLLICDIDHFKLYNDTYGHQKGDECLRCVAQILSSSTKRKTDLLARYGGEEFAMILPYSSWQGALHLGKLICDQVLGAKIPHETSNTSEYVTLSVGASCTIPDQKNNPDDLLKNADKALYQSKTKGRNQVNVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M2</accession>
    <name>K9Z8M2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3513"/>
    <dbReference type="EnsemblBacteria" id="AFZ55546">
        <property type="protein sequence ID" value="AFZ55546"/>
        <property type="gene ID" value="Cyan10605_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3513"/>
    <dbReference type="eggNOG" id="ENOG5031F3Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111939_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="24703" checksum="F2742674340FEE98" modified="2013-03-06" version="1">MWALPTLQVNKNKIMAKKNKTHQKSNNPQSKLTPPPIRLNHSPNQPKTTTTLSTVNQSSNSTNNQFTQPNNSTQLLTQSTRTIMVQPEQMSLTAHQQIQIYLQSKNRPSLEEKDLTAILRLSTHLRVFGLLSAVGYINQSNDQQGEVRQRTIPVWRSLLGQLINPENPPQARELMETVQNMARNNSTEYMMMWRKSLILSQYWNFWGRAYTQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8R3</accession>
    <name>K9Z8R3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220466.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2669"/>
    <dbReference type="EnsemblBacteria" id="AFZ54743">
        <property type="protein sequence ID" value="AFZ54743"/>
        <property type="gene ID" value="Cyan10605_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2669"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2834"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_1_1_3"/>
    <dbReference type="OMA" id="EWDNDEL"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="196" mass="22644" checksum="456159A76E32787E" modified="2013-03-06" version="1">MKNQLISIASLNHYSYCPHRFWRMFCASEFTDNQYTIDGTTLHERVHTVGDLNLGETWQIRAIYLKSEQYKLIGKADLIEAENGTFYPVEYKRGKKGEWANDELQVVAQALCIEEMTGTHVHTGYIYYAQTHQRQEVEINSSLRQSAIASIKAIQEIIEKETIPKAEYSKKCKGCSLYSACLPMAKDKINRYRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V0</accession>
    <name>K9Z8V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220511.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2715"/>
    <dbReference type="EnsemblBacteria" id="AFZ54788">
        <property type="protein sequence ID" value="AFZ54788"/>
        <property type="gene ID" value="Cyan10605_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2715"/>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516506_0_0_3"/>
    <dbReference type="OMA" id="TEWRDIT"/>
    <dbReference type="OrthoDB" id="1915732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="527" mass="56321" checksum="67DB3E9D33432E5E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V1</accession>
    <name>K9Z8V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_2963</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220744.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2963"/>
    <dbReference type="EnsemblBacteria" id="AFZ55025">
        <property type="protein sequence ID" value="AFZ55025"/>
        <property type="gene ID" value="Cyan10605_2963"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2963"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="CLFVNEE"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="13">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="14">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ55025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="46075" checksum="D6D78F61568FB89A" modified="2013-03-06" version="1">MHRAIKVRIYPNKTQAKKLSQVMGCCRWWYNYALNLCIDTYKATGKALKQVALNKYLPKLKKEEDTAWLGDCYSQCLQSTTLNLTKAFKNFFEGRAKYPRYKSYQGRQSCQYPQNVSIVDGCLKIPQLGLVKAVIHRIFEGEIKTVTVSKTPTGKYYASILFDTKQTFPEVTITGKVCGIDLGIKDFAIVHDGRKTSKYANPRHIKKHEKNLARKQQKLARKKKGSKNREKARKLVAKVHERISNARQDFLHKLSRKIVNNNQVVVIEQLNIKGMVRNHNLAKAISDVGWGTLINFLDYKLKQKGGLLVEIDRWFPSSKTCSHCHYQMSEMPLEIREWTCPSCGSHHDRDENASKNIRAEGIRKIQTDGTAVSASGGSVRPKGGRKSVLRHEPVKDEAPDSAIAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X2</accession>
    <name>K9Z8X2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54813">
        <property type="protein sequence ID" value="AFZ54813"/>
        <property type="gene ID" value="Cyan10605_2741"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2741"/>
    <dbReference type="eggNOG" id="COG2433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292624_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="24685" checksum="1629C2CA246B01DB" modified="2013-03-06" version="1">MRKSPQFIYQSLPAVTGLIVAGIINVTGGNALQTFMGLTTTAMGGYASTALIKKDTNILDKENREFKEVLGFKPELDDLKQQRELLMEKINNLKIEEEDLERRIIAIKRENYNLEELEKRVLKSQELKTEINELTGELNTIKQQIKEREYQRDNLSLVSSQFLQKQAELDDLKQHIDKLSKSKENLEVAKVNYEALNQKYTILENERNKILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Y7</accession>
    <name>K9Z8Y7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220784.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3005"/>
    <dbReference type="EnsemblBacteria" id="AFZ55065">
        <property type="protein sequence ID" value="AFZ55065"/>
        <property type="gene ID" value="Cyan10605_3005"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3005"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3202"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031758_5_1_3"/>
    <dbReference type="OMA" id="YGLPRVN"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="185"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="49394" checksum="07EF190CC84E7B1B" modified="2013-03-06" version="1">MLVSHPRYWLKNAHIPLCLIKDNLHLFSDTTRENLCLCDIEISQGKITQIIPACENTIGIDLKKGIVLPCFVDIHTHLDKGHIWERSPNLQGDFQTALATVREDSQRWNEEDLYRRMSFGLQCSYSQGTIALRTHLDCHDNQAEISLKVWQQLRQEWQGKISLQVVPLVSLDYFLTPEGEKLADKIAEMGGVLGGVAYMNPEIDTQIEKVFELAKERNLALDFHADESGEVESICLQKIAETALKTNFNQDILCGHCCSLAVQSPEKADEIIKLVKEANIAVVSLPMCNLYLQDREAGKTPFWRGVTRVKELKQAGVRVAFASDNCRDPFFAFGDHDLLEVFRESVRIAHLDTPYEDWIASVLEIPANLMNLPHLGKIALQSPADLIIFPARYFSELLSRTRFSQGFGHEMAQCNRILIRNGKIEKNSLPKYIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9A0</accession>
    <name>K9Z9A0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221020.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3256"/>
    <dbReference type="EnsemblBacteria" id="AFZ55302">
        <property type="protein sequence ID" value="AFZ55302"/>
        <property type="gene ID" value="Cyan10605_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3256"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3471"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591653_0_0_3"/>
    <dbReference type="OMA" id="KWYLQEA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033415">
        <property type="entry name" value="CHASE6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17150">
        <property type="entry name" value="CHASE6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="249"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="455" mass="51853" checksum="B2E4EBBB48588E51" modified="2013-03-06" version="1">MHVDSTLNQLKNLLGEDKLPSSYGVYFKNTLVALCHALEDHILQHHYEEEKYKPLLFVTFQKGKWYLQEAERYRDLAIHSRHITIAAVADSGFADHPTSQLANVDLIHLAEDDCLVQEWNLVILAPDYAAMVLCRELSPEEYYQGSEPQIDTERKFYGLWTFDRTLVEKAFTILTQSTSHYNPSLTEKLNQERSHLKNIPASGAVDLSGVVNRIVSYLQMSQEELYTVNRQTRELRDLEGQALKLNRNLGASKLQAFLRMAQRVDQNDPYNPCASLQVSALAETLGQILDLPTLRLRRLRLAGLLFRIGLAEAPQEVFARKSQNPETAQFWKDRPILSSRLLSSMSELQPINEIVLHQLEYWDGSGSPDGLKGTQIPLEARILGLVSYFQELTQPRGDRPAYSLSTALEKCQSYSGTRFDPDLVESLKTVIRLTEMGLMQLPNRPTQLPPVWLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9H1</accession>
    <name>K9Z9H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Integral membrane sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_3169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220938.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3169"/>
    <dbReference type="EnsemblBacteria" id="AFZ55220">
        <property type="protein sequence ID" value="AFZ55220"/>
        <property type="gene ID" value="Cyan10605_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3169"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3377"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_6_3"/>
    <dbReference type="OMA" id="MLLWIAW"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="477"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="729"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="932" mass="104003" checksum="CA7241389B3B4BB3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9J5</accession>
    <name>K9Z9J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221115.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55397">
        <property type="protein sequence ID" value="AFZ55397"/>
        <property type="gene ID" value="Cyan10605_3355"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3355"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3573"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_3"/>
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="14133" checksum="3472C2E718EE4857" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSQFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANGSLKELETHLMIIGRLGYLKEQELKVTLNKCEEIGRMLHSLIEKLSQNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9K0</accession>
    <name>K9Z9K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221120.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3360"/>
    <dbReference type="EnsemblBacteria" id="AFZ55402">
        <property type="protein sequence ID" value="AFZ55402"/>
        <property type="gene ID" value="Cyan10605_3360"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3360"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3578"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="OMA" id="LAFFEME"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12686" checksum="59FD2BB458869BF4" modified="2013-03-06" version="1">MNNQLLSLPITIPRKKLDKFCQVYHISKLSLFGSVLRDDFNENSDIDFLVEFKADYIPTFFKLSEMERVLSTLFNGRKIDLRTKEELSPYFRDKVIKEAVIQYDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N2</accession>
    <name>K9Z9N2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD(P)H-quinone oxidoreductase subunit 2</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD(P)H dehydrogenase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NADH-plastoquinone oxidoreductase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NDH-1, subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ndhB</name>
        <name evidence="12" type="ordered locus">Cyan10605_3390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221150.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3390"/>
    <dbReference type="EnsemblBacteria" id="AFZ55432">
        <property type="protein sequence ID" value="AFZ55432"/>
        <property type="gene ID" value="Cyan10605_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3390"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3610"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_3"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="OrthoDB" id="1664448at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045693">
        <property type="entry name" value="Ndh2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19530">
        <property type="entry name" value="Ndh2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="3 9" id="KW-0874">Quinone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Ndh2_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="10">
        <location>
            <begin position="130"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="525" mass="56252" checksum="88117F0AE65CD62D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P6</accession>
    <name>K9Z9P6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221165.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3405"/>
    <dbReference type="EnsemblBacteria" id="AFZ55447">
        <property type="protein sequence ID" value="AFZ55447"/>
        <property type="gene ID" value="Cyan10605_3405"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3405"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3627"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_0_1_3"/>
    <dbReference type="OMA" id="VYQDACH"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="456" mass="50810" checksum="A06FCC0D0E76398E" modified="2013-03-06" version="1">MNTTNTPIDTINSEKGFDDHNPPSQNLIDQCVHCGFCLSTCPSYRVIGKEMDSPRGRIYLMNAINQGEAKLDESTSPHFDSCLGCLACVTTCPSGVQYDQLIASVRPQVERNQPRNWWEKILRTLIFNIFPYPARLSIFLPLLWFYQISGLQALVRKTGILKFFPRIASMESILPSIQLASINKKYPYTIPPQKEKKYRVGLILGCVQRLFFDPVNEATVRVLTANGCEVVIPPSQGCCGALPAHQGQENQAQTLAKQMIDSFLSAEVDYIIINAAGCGHTLKEYHHILKDDPEGNCYAARIYEEKAKEFVSKVRDINEFLMETGFNVDLSPVTDDTVKVVYQDACHLLHGQKISLQPRQLLQKIPNLELKEPVDAALCCGSAGVYNLLQPDVANELGEQKVQNLLNTGASIIASPNPGCALQITKHLKLQGKEVKVMHPMELLDHSIRGELIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V8</accession>
    <name>K9Z9V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HI0933 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221088.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55370">
        <property type="protein sequence ID" value="AFZ55370"/>
        <property type="gene ID" value="Cyan10605_3326"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3326"/>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025174_0_1_3"/>
    <dbReference type="OMA" id="RCNFTNM"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="415" mass="46016" checksum="517AA27B51A03127" modified="2013-03-06" version="1" precursor="true">MIKKSQIVVIGGGAAGFFGAINCASVYPHVTVSILEAGKQPLTKVKISGGGRCNVTHHCFNPSELVNNYPRGGRELRGAFSRFQPQDTINWFEKRGVKLKTESDGRMFPITDNSQTVIDCLTDTATQLGIKIYTQTPVKDIDKSELGFNITLKSGEIIKAEKILIATGSNPNGYQWAKKLGHTIQTPIPSLFTFKIKDPRLADLAGITCDDVQLKLSLKKGKKLEQNGALLVTHWGISGPATLKLSAWGARILHDNKYNIPLIINWLPQRNYESVKEELINCKNTVAKQKVINYHGFDLPKRLWQSLVTYSLTNRDKTWAEITKKEIDKLTEELIRGVYQIQGKGVFKDEFVTCGGVSLKEIDFKTMMSKKCPDLYFAGEILDVDGVTGGFNFQNAWTTGWLAGLAMSANGERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Y8</accession>
    <name>K9Z9Y8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3504"/>
    <dbReference type="EnsemblBacteria" id="AFZ55537">
        <property type="protein sequence ID" value="AFZ55537"/>
        <property type="gene ID" value="Cyan10605_3504"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3504"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_6_0_3"/>
    <dbReference type="OMA" id="NRRWIRM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="20290" checksum="D2004020D285B07C" modified="2013-03-06" version="1">MWAEDEHRLGLKPVLRRVWVEKGYQPIATVNWGFQWLWLYGFVEPNTGETYWWLLPYVNTELFNRVLKDFAQHYEIGKNKRVILAMDQAGWHPIKETTEIPEGIHVMLMPSHSPELQPAERLWPLINEAIANRTFKNLEELEEVVISRCKKIMEEKEIVKGIANFYWWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA07</accession>
    <name>K9ZA07_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55425">
        <property type="protein sequence ID" value="AFZ55425"/>
        <property type="gene ID" value="Cyan10605_3383"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3383"/>
    <dbReference type="HOGENOM" id="CLU_2933654_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="60" mass="6971" checksum="9E15A5D5E150F929" modified="2013-03-06" version="1">MENKEKEIRLVSNENPQPFLLSVSQNQTLLSFADLQVYQTVEFSKIKRKQSARLALIYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA30</accession>
    <name>K9ZA30_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221292.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3544"/>
    <dbReference type="EnsemblBacteria" id="AFZ55577">
        <property type="protein sequence ID" value="AFZ55577"/>
        <property type="gene ID" value="Cyan10605_3544"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3544"/>
    <dbReference type="eggNOG" id="ENOG5033K2J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171584_0_0_3"/>
    <dbReference type="OMA" id="SRYLYYC"/>
    <dbReference type="OrthoDB" id="1740780at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="11262" checksum="9B43306591E0A38E" modified="2013-03-06" version="1">MQLFQINNNFPEADFWLINKSSIAQIGKPVKEYRSCLTGIKCNEQLILPSFGFYACLHLYQTGIWRGYGRSCINLVSLRIKDIRNVLNNYFVIQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ62</accession>
    <name>K9YZ62_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_tran_28_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0060"/>
    <dbReference type="EnsemblBacteria" id="AFZ52221">
        <property type="protein sequence ID" value="AFZ52221"/>
        <property type="gene ID" value="Cyan10605_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0060"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.62"/>
    <dbReference type="eggNOG" id="COG4671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055279_0_0_3"/>
    <dbReference type="OMA" id="GYNTFCE"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016683">
        <property type="entry name" value="Glyco_trans_28_RedA_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017085">
        <property type="entry name" value="Glycosyltransf_RedA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="302"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="446" mass="51232" checksum="B27FB00C95FA9BBA" modified="2013-03-06" version="1">MNIALPYFKNLWTHHRNVVPISEPQIKINQYFAVKKEQIFPKKLKIVLYSHDTMGLGHKRRNQLIAQTLEESGISGNILIISGIGEGNQFFSSSAIDYLTLPALYKSSDGEYRARHFDMSLKQIIKMRSQIILTAMKNFQPDVFIVDNVPRGAINELNPILKYLRKKTKTKCILGLRDILDDPDVIKNSWQKNNYEDAIRKYYDQVWIYGDEQIYDSIQEYTFSPDIASKLHYTGYLDQTARIQWYQKHHHKTDLHFPSNSLALCMVGGGQDGGNLALAFAQSKLPKNTYGIIVTGPMMPPSVRQQIQEYCEMPSQNGAVRSNLQVLEYVNEPTLLLKKADWVVSMGGYNSTCEILSFQKRALIVPRITPRKEQLIRTEILNKLGFVDMLHPQQLSADALSQWFRQEKKHHPQTVNIDLDGLKKIPQLITEIVKKKKNSAKILLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ79</accession>
    <name>K9YZ79_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ordered locus">Cyan10605_0043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217936.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0043"/>
    <dbReference type="EnsemblBacteria" id="AFZ52204">
        <property type="protein sequence ID" value="AFZ52204"/>
        <property type="gene ID" value="Cyan10605_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0043"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.45"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_1_3"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17099" checksum="DA8439CD33C08C07" modified="2013-03-06" version="1">MTEQKISHLNSQGEVQMVDVSLKSVTSRTAIASGKVLLNPTALETILKQKNPKGDLIATAKIAGIMGAKQTSSLIPLCHPLPLQKIAIDIHLNQDNYCYEISASTKTNAETGVEMEALTAVSIAALTLYDMLKAIDKSITITDIKLVSKTGGKSDYNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZD5</accession>
    <name>K9YZD5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ordered locus">Cyan10605_0149</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218038.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0149"/>
    <dbReference type="EnsemblBacteria" id="AFZ52306">
        <property type="protein sequence ID" value="AFZ52306"/>
        <property type="gene ID" value="Cyan10605_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0149"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.155"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_3"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="185"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="362" mass="40162" checksum="8E790FCB1ECBFF46" modified="2013-03-06" version="1" precursor="true">MSVKQPRLLIAASGTGGHLFPALAVAQQLPDYHIQWLGVPNRLETTLVPSDYRLHTVDIEGFQTSFGIKTIFVMGKMLSAIARTYQIIKKSKIEIVFTTGGYIAAPAIIAAKLAKIPVILHESNYIPGKVTKLLGKWCKLVAIGFRGTEKYLPKSKTQWVSTPVREEFLQPQTLPLDIPDDVPLIVAMGGSQGAVALNKLVRRSAPQILDTGAYIVHLTGNQDDEIGTFTHPHYLEMPFYDKMGALLQRANLAISRSGAGSLTELAITKTPSILIPYPFAAEDHQFFNGQEFVNTEASLMFRQEHLSPELLTETVLDLLNNHDKLMKMSSHAQQLADRNSASAIAHIIMNELTYTRRENKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZK4</accession>
    <name>K9YZK4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Folate/biopterin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218113.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0227"/>
    <dbReference type="EnsemblBacteria" id="AFZ52381">
        <property type="protein sequence ID" value="AFZ52381"/>
        <property type="gene ID" value="Cyan10605_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0227"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.236"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018563_3_2_3"/>
    <dbReference type="OMA" id="GIDDHWF"/>
    <dbReference type="OrthoDB" id="1165704at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="PTHR31585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="52418" checksum="1562A71242BC3D99" modified="2013-03-06" version="1">MFINTYWLKNLREFIESKILFGNKLTPELFAILTVYFVQGILGLARLAVSFFLKDDLLLSPAQVSALMGIAAIPWITKPVIGFLSDGKPIFGYRRRSYLLLSGVLGAIAWLSLATIVNNLTGAIIAILCTSLSVAISDVIVDSVVVERAKSESVAQAGSLQSVTWGFSAIGGLITAYFSGLLLEHFSNSQVFLITACFPLLVVGIAGLIIEQPVVEKKDIGDFKEQIKQIWHTFKQKTILYPVIFVFLWQMTPSADSAFFFFSTNELGFTPEFLGRIRLITSLASLIGIWCYQQWLKQISFRVILGWSVVLSSLLGMTSLILVTHLNRQWGIDDHWFSLGDSLVLTVMGQIAFMPVLVLSARLCPEGIEASFFALLMSIWNLGGLLSHELGALLTQWLGVTETNFDRLWLLLLITNLSTLLPLPLLKLLPNEDPQGHVSGENLPVSEIYEHHLSGASINTEMLPDVMTNFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZM5</accession>
    <name>K9YZM5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phycobiliprotein ApcE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_0251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phycobiliprotein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phycobilisome linker protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218133.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0251"/>
    <dbReference type="EnsemblBacteria" id="AFZ52401">
        <property type="protein sequence ID" value="AFZ52401"/>
        <property type="gene ID" value="Cyan10605_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0251"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.260"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007759_0_0_3"/>
    <dbReference type="OMA" id="FYTPYPN"/>
    <dbReference type="OrthoDB" id="20391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001297">
        <property type="entry name" value="PBS_linker_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038255">
        <property type="entry name" value="PBS_linker_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00427">
        <property type="entry name" value="PBS_linker_poly"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51445">
        <property type="entry name" value="PBS_LINKER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="10" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="6" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="PBS-linker" evidence="12">
        <location>
            <begin position="266"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PBS-linker" evidence="12">
        <location>
            <begin position="523"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="PBS-linker" evidence="12">
        <location>
            <begin position="719"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="914" mass="102070" checksum="E85DF66ECC3FB6E6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZQ2</accession>
    <name>K9YZQ2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218126.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0242"/>
    <dbReference type="EnsemblBacteria" id="AFZ52394">
        <property type="protein sequence ID" value="AFZ52394"/>
        <property type="gene ID" value="Cyan10605_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0242"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.251"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_3"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="670" mass="72323" checksum="133F7545B1792518" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZU7</accession>
    <name>K9YZU7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0329"/>
    <dbReference type="EnsemblBacteria" id="AFZ52476">
        <property type="protein sequence ID" value="AFZ52476"/>
        <property type="gene ID" value="Cyan10605_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0329"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.343"/>
    <dbReference type="eggNOG" id="ENOG50310GY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090005_1_1_3"/>
    <dbReference type="OMA" id="KSARRTC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021381">
        <property type="entry name" value="DUF3011"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11218">
        <property type="entry name" value="DUF3011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="216" mass="23909" checksum="E16207E8D63BB399" modified="2013-03-06" version="1" precursor="true">MKPQKECLSVLVNKKEKLKMKHWYKLALISVISCGFFAQATPASAESRLTCESYKGRYKFCDADTRGGVKLIRQLSRTECRQGSTWGYDRNGIWVDRGCSAEFAVRGRGDNYNNNNNSSGDNTAAIIGGVLAVGAIAAAIASSSDNNNYDGGNTITCNSDRGNYTRCGADIRRGDRVVMRRQLSNSGCWEGSTWGYDRNGIWVDQGCRGVFEIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZW3</accession>
    <name>K9YZW3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218186.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0306"/>
    <dbReference type="EnsemblBacteria" id="AFZ52454">
        <property type="protein sequence ID" value="AFZ52454"/>
        <property type="gene ID" value="Cyan10605_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0306"/>
    <dbReference type="eggNOG" id="ENOG5034648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033341_0_0_3"/>
    <dbReference type="OMA" id="YNEYSIY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="31328" checksum="5B426E746428391D" modified="2013-03-06" version="1">MSLIYLQESKIEASFLIAIYALNMGDNLGTTLDLSSVEFIPLKIAFSVLNHLSVEREINDEFHQKIYNEYSIYPDSLSPSEGAIAFFPLFLFYYGDNRNLDKKLELIKDNYFSSNTNLNSWKILIIIINLILQKKLEIDKITLQTVSFLEKYTLEELEAIKIVEHLIREKIYLTEAEKILQAKIDNHELGIYQALYSFLCLPNNIPMSLSRSKQFIHQQETTRILTGFLLGLYNGYSPIYSFVNFTYQEKAFEQIIDQFVAQWRGKIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZW7</accession>
    <name>K9YZW7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218191.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0311"/>
    <dbReference type="EnsemblBacteria" id="AFZ52459">
        <property type="protein sequence ID" value="AFZ52459"/>
        <property type="gene ID" value="Cyan10605_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0311"/>
    <dbReference type="HOGENOM" id="CLU_124347_0_0_3"/>
    <dbReference type="OMA" id="TYGSFGW"/>
    <dbReference type="OrthoDB" id="2053514at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21562" checksum="AA7BF6AFE6DF0284" modified="2013-03-06" version="1">MPRKNNSLEKDDYNSWLNSNLLVSLSLFLCTYTVLGWAIASTAGFWLFLLEQQNISLTFLIEQDSLLFIIKIVALFVIITISLFLSTPVALITFVFEESINSDIKAFIAILFWSVLLVFIFCSFEYFADLLVVTAVNILFRLDLQKLKYPRWVVRLIIFTLAFLSFMSGVYLFDHFNSGNITDSYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZY6</accession>
    <name>K9YZY6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="6">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fni</name>
        <name evidence="8" type="ordered locus">Cyan10605_0332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218211.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9YZY6"/>
    <dbReference type="STRING" id="755178.Cyan10605_0332"/>
    <dbReference type="EnsemblBacteria" id="AFZ52479">
        <property type="protein sequence ID" value="AFZ52479"/>
        <property type="gene ID" value="Cyan10605_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0332"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.346"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_3"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="178"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="295"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="345" mass="38097" checksum="1D9A572C56F31857" modified="2013-03-06" version="1">MVNLTETQSRKDDHIRICLDEKVQVNQITNGLEKYQFTHVCLPELDYQEIDINTTFLNRQLNTPLLISSMTGGTENAQLINQRLARIAQKYGLPMGIGSGRVIIEKPEIASTFQVRDNAPDIMLLANLGAVQLNYGYNWQECLKLVEILEADALILHFNPLQECIQPEGDTNFKDLLTKIEQVCDKLPIPVIAKEVGNGISVKMAEKLINAGIQAIDVAGMGGTSWAMVESERAKNPLQKELGKTFANWGIPTADCVRDIRQQYSEIPLIASGGIRNGLEVAKMLALGADVVGLAYPFLKTAMTSEEAIEELVKLIIAEIKTVLFCTGNKNINSLKTSQNLTINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z069</accession>
    <name>K9Z069_CYAAP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Cyan10605_0420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218295.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0420"/>
    <dbReference type="EnsemblBacteria" id="AFZ52564">
        <property type="protein sequence ID" value="AFZ52564"/>
        <property type="gene ID" value="Cyan10605_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0420"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.444"/>
    <dbReference type="eggNOG" id="ENOG50330KB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185225_0_0_3"/>
    <dbReference type="OMA" id="PKGEWND"/>
    <dbReference type="OrthoDB" id="2022003at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8760" checksum="15C262A179B14B3E" modified="2013-03-06" version="1">MNNNTLSEGRGAEKVEISIHIDSELLEKVSHLTNDPSRIIESALKQWLRGERQQDDDLTRSLRRNPPVPPRGEWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0H6</accession>
    <name>K9Z0H6_CYAAP</name>
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        <submittedName>
            <fullName evidence="4">Forkhead-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218412.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0540"/>
    <dbReference type="EnsemblBacteria" id="AFZ52681">
        <property type="protein sequence ID" value="AFZ52681"/>
        <property type="gene ID" value="Cyan10605_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0540"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400989_0_0_3"/>
    <dbReference type="OMA" id="IYQGISW"/>
    <dbReference type="OrthoDB" id="562698at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="678"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="715" mass="82730" checksum="78633B34751C6656" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J7</accession>
    <name>K9Z0J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218437.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0565"/>
    <dbReference type="EnsemblBacteria" id="AFZ52706">
        <property type="protein sequence ID" value="AFZ52706"/>
        <property type="gene ID" value="Cyan10605_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0565"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.596"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_3"/>
    <dbReference type="OMA" id="WRGVRTD"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="914" mass="100483" checksum="66B47C8866E917AD" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S4</accession>
    <name>K9Z0S4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ordered locus">Cyan10605_0175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218064.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0175"/>
    <dbReference type="EnsemblBacteria" id="AFZ52332">
        <property type="protein sequence ID" value="AFZ52332"/>
        <property type="gene ID" value="Cyan10605_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0175"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.183"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_3"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="27288" checksum="4DACA5B6FF2768AD" modified="2013-03-06" version="1">MEVIPAIDLLAGRCVRLYQGDYEQSQVFSENPLEIALQWQSLGATRLHLVDLDGAKEGTTINLDAISTIVKNLNIPIQVGGGLRDRTSVERLFDLGVERAIVGTVAVEKPELVEELCNTFPHKIAVGIDARNGKVATKGWLETSTVEATDLAQRISDKAAAIIYTDISRDGTLVGPNIEALKQLAQVTDIPVIASGGISSLTDLLSLVSLESLGVRGVIVGKAIYTGKLDLKEAIQAIGNGRLQDIPPDIGNSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U7</accession>
    <name>K9Z0U7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ordered locus">Cyan10605_0645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218515.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0645"/>
    <dbReference type="EnsemblBacteria" id="AFZ52784">
        <property type="protein sequence ID" value="AFZ52784"/>
        <property type="gene ID" value="Cyan10605_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0645"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.681"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_2_1_3"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14036" checksum="10B479DEE0E3A86A" modified="2013-03-06" version="1">MANSRRVEKVSSLIRKEISQMLISGIKDDRVGAGMVSILDVEMSGDLQHAKVFVSIYGTPEAKAETMEGLKACTPFVRRELGHRIRLRHTPEIRFVHDSSLEKGDQIIDLINRITPHDVPSAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z123</accession>
    <name>K9Z123_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218164.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0283"/>
    <dbReference type="EnsemblBacteria" id="AFZ52432">
        <property type="protein sequence ID" value="AFZ52432"/>
        <property type="gene ID" value="Cyan10605_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0283"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.293"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_1_3"/>
    <dbReference type="OMA" id="YMNLKFY"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="10844" checksum="BDCA2D34CF3D47ED" modified="2013-03-06" version="1">MNKQQVIDIIKAHQTQIHDFAVKELFLFGSVARGEETEDSDVDFLVNFNQPVGLFTLLKLKSYLEDLLGCSVDIGTSESLRPHLKETVLKEVIRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z140</accession>
    <name>K9Z140_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218007.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52275">
        <property type="protein sequence ID" value="AFZ52275"/>
        <property type="gene ID" value="Cyan10605_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0116"/>
    <dbReference type="eggNOG" id="ENOG502ZJHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1632634_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="18302" checksum="4DCD775618ACDC7E" modified="2013-03-06" version="1">MATKRVNNEFHRLDVKLPIDVYEQISKIAVNSFSARIHHISGKPEITQTLIYLLELGIQSFLDGNELIKKYDTDKYTDTIPITEKGVKQLIKEELVPIQSRLNELSEAIHRLTYTDNNTDILSIAVNEGTLAKIADNNTDKYADKIEIDTDNITPSESLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q5</accession>
    <name>K9Z1Q5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanosine(18)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA [Gm18] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmH</name>
        <name evidence="6" type="ordered locus">Cyan10605_0365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218241.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0365"/>
    <dbReference type="EnsemblBacteria" id="AFZ52510">
        <property type="protein sequence ID" value="AFZ52510"/>
        <property type="gene ID" value="Cyan10605_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0365"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.384"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_4_2_3"/>
    <dbReference type="OMA" id="KIPMVGF"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022724">
        <property type="entry name" value="rRNA_MeTrfase_SpoU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="PTHR43453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12105">
        <property type="entry name" value="SpoU_methylas_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SpoU_methylas_C" evidence="5">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26790" checksum="3CDED8A6D6F5098C" modified="2013-03-06" version="1">MDYRRLEKIKRILQRRQPDLTLITDNVNNFRNLSAIIRSCEAVGTMEVHLVNNQQEKLYLINKVTAGAERWLTQTRHSSIVTGINHLKKRGFTIYATHLGDPEGICCAVRTLDYRKMDYTKPTAFVVGSEKKGISEEALENADYHISIPMMGMTQSLNVSVATAIILFEAQRQREEKGYYQQLRTSQEIYEKTIFEWAYPEAALAYRANKKPYPPLTETGEIKRDYKSSKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S9</accession>
    <name>K9Z1S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218055.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0166"/>
    <dbReference type="EnsemblBacteria" id="AFZ52323">
        <property type="protein sequence ID" value="AFZ52323"/>
        <property type="gene ID" value="Cyan10605_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0166"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.174"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_2_3"/>
    <dbReference type="OMA" id="HRFWSAV"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="18275" checksum="314F3F4CF4863005" modified="2013-03-06" version="1">MSQSISATEADWQREKIEKWWSPSKQLLKSIREYQKWQSSNFPFKAIFMKWNALQHRFWSVVTGAEIHLNTKKMGGGLVLTHPNGVVIHPDVEIGVNCLILQQVTIVKGVKIGGHVDIHAGAKVIRSVTIGDHAKIGANAVVLTDVPEGATAVGVPARIILPTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T5</accession>
    <name>K9Z1T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218403.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0530"/>
    <dbReference type="EnsemblBacteria" id="AFZ52672">
        <property type="protein sequence ID" value="AFZ52672"/>
        <property type="gene ID" value="Cyan10605_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0530"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.561"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_3"/>
    <dbReference type="OMA" id="VTNKFPI"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="440"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="561" mass="59551" checksum="1E3DC60B9D927B15" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z0</accession>
    <name>K9Z1Z0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218463.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0593"/>
    <dbReference type="EnsemblBacteria" id="AFZ52732">
        <property type="protein sequence ID" value="AFZ52732"/>
        <property type="gene ID" value="Cyan10605_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0593"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_3"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="327"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="469"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="719" mass="83416" checksum="222E8AF7BD70EBBE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z212</accession>
    <name>K9Z212_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ordered locus">Cyan10605_1104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218957.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1104"/>
    <dbReference type="EnsemblBacteria" id="AFZ53226">
        <property type="protein sequence ID" value="AFZ53226"/>
        <property type="gene ID" value="Cyan10605_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1104"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1168"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_3"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22449" checksum="96C5B88F2634A4A3" modified="2013-03-06" version="1">MNEKKLVIPEVIIGLGNPEKKYEQTRHNIGFEVVDFLADKWGGSLQKNTKFNALFCEVVTPNRQKIKLVKPLTYMNKSGQSVRAVLDWYKLTRESILVVYDDMDLEFGRIRLRLSGSAGGHNGMKSIISHVGGQDFPRFRIGIGKSGHKDATIGHVLGKFSAEERKEMNSLMLLVYDAIASSLTDGVEKTMSLYNKKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z226</accession>
    <name>K9Z226_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218915.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1060"/>
    <dbReference type="EnsemblBacteria" id="AFZ53184">
        <property type="protein sequence ID" value="AFZ53184"/>
        <property type="gene ID" value="Cyan10605_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1060"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1122"/>
    <dbReference type="eggNOG" id="COG3670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_3_3"/>
    <dbReference type="OMA" id="HHIPYGL"/>
    <dbReference type="OrthoDB" id="389495at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="489" mass="55498" checksum="8758486CBE77F64C" modified="2013-03-06" version="1">MQQLEKPIQKPYSLEDWRKGYESQKQELEYWIEDIEGEIPQELSGTLYRNGPGFLDVYGTPLQHPFDGDGMITAFTFNEGKCFFRNRFVKTKEFLEEQKAGKMLYRGVFGSQKPGGWLANLFDLKIKNIANTNVLHWGGKLLALWEAAHPYHLNPENLETVGLDNLDGILEAGEVFSAHPRIDPASSFNNGKPSLVNFGVKTGLSSTITIYELDEKGKLLQKYSHIIDGFSFIHDFVITPNYCIFFQNPTTYNPFPFLFGLRGAGECVKFLDNQPTKIILIPRNAPHKDVITLETEAGFIFHHANAFEVNEQEIVVDSICYAKLSQIDPDTSYKEVDFDKLAPGQLWRFQLNLQDGKVTKKLIDPRCVEFPSIHPNKVGRDYRYLFIGSAHHPTSNAPLQALLKLDLQTNEQQFYSFAPKGFAGEPVFVPKANPQSEDDGWVFNLIYDSSRHKSDLVIFDGQDISSPVATLHLKQHIPYGLHGSWKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z243</accession>
    <name>K9Z243_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218523.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0653"/>
    <dbReference type="EnsemblBacteria" id="AFZ52792">
        <property type="protein sequence ID" value="AFZ52792"/>
        <property type="gene ID" value="Cyan10605_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0653"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.689"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047710_0_0_3"/>
    <dbReference type="OMA" id="TIDAYFQ"/>
    <dbReference type="OrthoDB" id="874989at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="422" mass="46843" checksum="0B0E0E62D9A97F6A" modified="2013-03-06" version="1">MNDHQSEEINVSLDKNNSEIENNNSNSTLIPPKQLTYVKRPKTSHSGKILIGLGISFAGILLDNSWLGVIGSIVAFSLALVQVIPYIIQWIRFFLTPQERQTVVGVVGLILASLILFNYLGVYHAVGNWLNQFKYDEFGSWADWVGALGQIMIAVLAVYVAWQQYVISKDLTIQQNRITQQQTIDAYFQGLSELVLGPDGLLEDWPQERAIAEGRTAAILSSVDGSGKAKILRFLSRSRLITPLKRDSHLGRPILDGSGGYAEDREFGMRVINLGVVLAGCNLMGQDLRWTDLSEANMVRTDLSKADLVKTNLARTILYEADLQGADMKGVRLFYGDFHSASPRSRTQAPNFETGEYTGAVIEKVNFTGVKNLSEENRYYCCCWGGEYTRSTIPGGCLGIPDCLTASRRQQENLESEDAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C1</accession>
    <name>K9Z2C1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218436.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0564"/>
    <dbReference type="EnsemblBacteria" id="AFZ52705">
        <property type="protein sequence ID" value="AFZ52705"/>
        <property type="gene ID" value="Cyan10605_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0564"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.595"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_3"/>
    <dbReference type="OMA" id="WEFPPRI"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="396" mass="45284" checksum="503508131F351963" modified="2013-03-06" version="1">MRILVLSWEFPPRIVGGIARHVAELYPEIVKLGHEVHLITVRSGDSPILEQVEGINVHRLEVIPEDDFFRWITYMNNVMRSYAEDLISQMGGFDLIHAHDWLVADSAIPLKHRFKIPLITTIHATEYGRHNGIHNETQAYIASKEGTLIYESWRVIVCSDYMRFEVHRALGCPKDKIDIIYNGIRPEKKARLPLFDSQKFRRKFAQDDEKIIYYVGRMTYEKGIHVLLKAAGKVLQDLNGKVKLVIIGGGNTDFYQDLAHSLGIWQHCNFTGFMSEEDLNKFTTIADCAVFPSLYEPFGIVVLESFASCVPVVVSDAGGLPEVVRHTNTGIVTQVNNPHSLAWGILEILKNPDYAQSMVKNAYQDLFTRFQWSKLAQQTINTYHIVAKERQLTIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I1</accession>
    <name>K9Z2I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218319.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0444"/>
    <dbReference type="EnsemblBacteria" id="AFZ52588">
        <property type="protein sequence ID" value="AFZ52588"/>
        <property type="gene ID" value="Cyan10605_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0444"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_0_3"/>
    <dbReference type="OMA" id="RADGNVM"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="33889" checksum="2ACB37906EC21683" modified="2013-03-06" version="1">MFNHGLVCTDFTDGLDKMIHFVSALGEGGFKEITFLHSVAIWNEGEIPRIDRDKVEEAKKKLSPALNNVPENMKVNIEVLSGNPSDNILATIKKYNIDLVITGSPVSTSLEQIFFGSTTAKLRNKLRIPMMILRPQLMSVYRNDEFALRCRNLNSFWLVPYNHAPHHRYILEKIRGYVEIDKGNTLKECLFLSVIDEVSRSEILTENKVKEAENKLAEIQKSFVSSPINVQTLVKRGNILEETFKIAFAHDVSAIALADNLKEDSIFNRLVQLAVGNNANYLLNCSWFPLIYFPMNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K1</accession>
    <name>K9Z2K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218526.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0657"/>
    <dbReference type="EnsemblBacteria" id="AFZ52795">
        <property type="protein sequence ID" value="AFZ52795"/>
        <property type="gene ID" value="Cyan10605_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0657"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.692"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_3"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="52253" checksum="C6808FE80BF22A66" modified="2013-03-06" version="1">MTSIKKLHQQIKNKERSAVEITQEYLQRIGELEPKLKSFLCVTSDLALETAKQVDEKVASGEEIGVLAGIPIAIKDNMSTKGIPTTCASRILENFIPSYESTVTQKLRDQGAVIVGKTNLDEFAMGSSTENSGYQVTANPWDIERVPGGSSGGSAAAVSADECVVSLGSDTGGSIRQPASFCGVVGLKPTYGLVSRFGLVAYASSLDQIGPFAHTVEDTAILLGAIAGYDSKDSTSLNVEIPDYTQSFATDLKGLKVGVIKETYSDGLDNIVAEKVNQAIKELEKLGAQVKEISCPRFRYGLPIYYIIAPSEASANLARYDAVKYGIRDESADNLLEMYTKTRAKGFGAEVKRRIMLGTYALSAGYYDAYYLKAQKVRTLIKQDFDNAFHDVDVLISPTSPTTAFKAGEKTDDPLSMYLSDLMTIPVNLAGLPGMSLPCGFDENNLPIGMQLIGNVLREDVLFKVGYAYQQVTDWHNQNPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2M2</accession>
    <name>K9Z2M2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ordered locus">Cyan10605_1336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1336"/>
    <dbReference type="EnsemblBacteria" id="AFZ53451">
        <property type="protein sequence ID" value="AFZ53451"/>
        <property type="gene ID" value="Cyan10605_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1336"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1411"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_3"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="38495" checksum="18487E2C3B80D745" modified="2013-03-06" version="1">MLGEINSTMLPFALSELLIKFMTIIWLASILDYLIGDPKNWFHPVQLIGWIIEKSVNFVIHQTENKTVRKIAGVILGLVLVLGSGVITWLIIYLLSRVNFWLGFVFQVILLASCFAGRSLSDAAEDVLSALKENNLSEARHRLSFYVGRDTDNLSTEEIYRAVLETVSENATDGVTAPLFYALLGSFIPIVGCVPSAIAYKTLSTLDSMIGYKREPYQDIGWFSAKWEDYITWLPCRLTVLTLGLISLNPIYNIKECRKYAIQDPSPNSGWSEGIYAVILKVQLGGENSYQGVKKFKPLLGKPEREIDETVIKKALFLTRFCFLLWLLLGVLIFSITYLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Q1</accession>
    <name>K9Z2Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1367"/>
    <dbReference type="EnsemblBacteria" id="AFZ53481">
        <property type="protein sequence ID" value="AFZ53481"/>
        <property type="gene ID" value="Cyan10605_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1367"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1442"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_3"/>
    <dbReference type="OMA" id="WHENGLE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="496"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="758"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="879" mass="99522" checksum="E52CB36402A073CE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T9</accession>
    <name>K9Z2T9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ordered locus">Cyan10605_1414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219255.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1414"/>
    <dbReference type="EnsemblBacteria" id="AFZ53526">
        <property type="protein sequence ID" value="AFZ53526"/>
        <property type="gene ID" value="Cyan10605_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1414"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1495"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_3"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="254"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="600" mass="69759" checksum="DF5F0F9F1EE21A33" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2W2</accession>
    <name>K9Z2W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218651.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0787"/>
    <dbReference type="EnsemblBacteria" id="AFZ52920">
        <property type="protein sequence ID" value="AFZ52920"/>
        <property type="gene ID" value="Cyan10605_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0787"/>
    <dbReference type="eggNOG" id="ENOG503377W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890585_0_0_3"/>
    <dbReference type="OMA" id="WANDEDE"/>
    <dbReference type="OrthoDB" id="1065887at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="312" mass="36375" checksum="E8F752D6D7639609" modified="2013-03-06" version="1">MSKLRGNNVMNNSVKLRSYYSSNIEAIALLYNSAEENQDELFWEEIKEPFRSILEECYCISEEGKYNQLEQITNSIKYNRISYIKLGVQLYQVKYYRLYKNKYKSFKDYCEQGVYYPVWRANQVIASAGVAIKLIKAGFNIIPQNETQARLLIKLKEEELLAKWQEVLDTYAPHKITANRIEAIVFGINKRTKGTLRLPVKVIQEIENKALESGMSTGELITKIIQGELTINSDGTMEKMIKEKDEIVENPSPESIKRWEKDLNQLAFQERNRLDDFTEELAEELKNTVLDLKQVIKKCFMKSFLSPCMLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z9</accession>
    <name>K9Z2Z9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219315.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1475"/>
    <dbReference type="EnsemblBacteria" id="AFZ53586">
        <property type="protein sequence ID" value="AFZ53586"/>
        <property type="gene ID" value="Cyan10605_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1475"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1565"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027053_0_0_3"/>
    <dbReference type="OMA" id="INNWIRR"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="665" mass="75956" checksum="C875E743DAB67D5F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z381</accession>
    <name>K9Z381_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">Cyan10605_0687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218554.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0687"/>
    <dbReference type="EnsemblBacteria" id="AFZ52823">
        <property type="protein sequence ID" value="AFZ52823"/>
        <property type="gene ID" value="Cyan10605_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0687"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.721"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_3"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="533" mass="59402" checksum="55F8723E27DA5FD7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z385</accession>
    <name>K9Z385_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photosystem II reaction center protein L</fullName>
            <shortName evidence="8">PSII-L</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">psbL</name>
        <name evidence="9" type="ordered locus">Cyan10605_0692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cellular thylakoid membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PsbL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218559.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0692"/>
    <dbReference type="EnsemblBacteria" id="AFZ52828">
        <property type="protein sequence ID" value="AFZ52828"/>
        <property type="gene ID" value="Cyan10605_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0692"/>
    <dbReference type="eggNOG" id="ENOG5033AKP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_214425_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01317">
        <property type="entry name" value="PSII_PsbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003372">
        <property type="entry name" value="PSII_PsbL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037266">
        <property type="entry name" value="PSII_PsbL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02419">
        <property type="entry name" value="PsbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161017">
        <property type="entry name" value="SSF161017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="2 8" id="KW-0674">Reaction center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="39" mass="4486" checksum="FEDDF6A8C0B5F29B" modified="2013-03-06" version="1">MDRNQNPNKQPVELNRTSLYLGLLLIAVLGVLFSSYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H9</accession>
    <name>K9Z3H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219021.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1171"/>
    <dbReference type="EnsemblBacteria" id="AFZ53292">
        <property type="protein sequence ID" value="AFZ53292"/>
        <property type="gene ID" value="Cyan10605_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1171"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1237"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039825_0_0_3"/>
    <dbReference type="OMA" id="VFLCGSI"/>
    <dbReference type="OrthoDB" id="365080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025904">
        <property type="entry name" value="Tubulin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13809">
        <property type="entry name" value="Tubulin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="501" mass="56405" checksum="BF2088F694ECDC22" modified="2013-03-06" version="1">MSFYVIGIGGTGAKCIEAIAHLASVGLIPTNMLKVLYIDADETNGNLQRSQRTVSIYQRCFQLLKGKHQECAWMTTNLESYGVWSPFTNNNADRKLGSFFSYETLKQTSPPLGNLFDVLYTEDERQVSLEVGFRGRPAIGSSIMTQINLESLEQEPWRSLINEIENNAGGGSQTKVLLCGSIFGGTGASGLPTIGRLIANKLEKDGVRDRVKIGCIFGLPYFNFPKNSNTNEQVYASSDLFLLNTEAALRYYKEQANQFDTKYLIGNQSMEKLGDFSVGKDTQVNRPHFVEFYAGLAARHFFCDNPPEGVHVMSRNEAGILQWDDIPHVEEVKAKLVNAARFAFIWLADFEDQLQKAKTAGIRELNGLAWFDKFFRGTKKFIGGYQRPHLPDLSESDQQDAIKSVTAWCEDFLRWLKDIHYCDNERVQLFKAREYFGNPKSLKGEKFSDLLWDDSRSKELLQDDNAITLKNKIGELDTRDFGEPNQGVAGLAKAVYVCCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J1</accession>
    <name>K9Z3J1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0815"/>
    <dbReference type="EnsemblBacteria" id="AFZ52948">
        <property type="protein sequence ID" value="AFZ52948"/>
        <property type="gene ID" value="Cyan10605_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0815"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.858"/>
    <dbReference type="eggNOG" id="COG1429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567584_0_0_3"/>
    <dbReference type="OMA" id="PAMEGVI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="20728" checksum="7D34EAFF70DD3E04" modified="2013-03-06" version="1">MHRIPATPGGWNPDTEGVIFIEQNPAPIIFITSADTDIQTTAACLEKLPEDFPSMRVVNLLQLQQELTIDTYAEEVLSHAKVIILRLLGGRSYWSYGLEVCKDTVSQTNASLFILPGDDRPDAELFSQSNMSISQVNLLWRYLTEGGVENFANGFKFIANTCLNTNYSYQLPLEIPRLGIYSCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3T0</accession>
    <name>K9Z3T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218951.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1098"/>
    <dbReference type="EnsemblBacteria" id="AFZ53220">
        <property type="protein sequence ID" value="AFZ53220"/>
        <property type="gene ID" value="Cyan10605_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1098"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1162"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_1_3"/>
    <dbReference type="OMA" id="DWALRWF"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="302" mass="33403" checksum="53A5D3EE87588A09" modified="2013-03-06" version="1">MKYQFYTLDVFTNQPFAGNQLAVFPHSEGLSSDIMRKIAVEFNFSETVFVFPASNSQADYQVRIFTPGGEIPFAGHPTIGTAFLLAHLGMVTLKSSATQIILEEKVGLVPVNIYTDNGIVKSSELTAPNPPEFFHNIPSKKALAEVLSLSETDLHSDFSPQAVSCGLPFMIIPLNSQKALSEAKINLSHWEKTLRNTLFPHVYPCYPVSKNLWRVRMFAPALNIIEDPATGSAATAFAAYLVQSQQETDGSWQWLIEQGIEIGRNSKITAIATKQKGIIKDIKVKGECVIITEGYLHLKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V6</accession>
    <name>K9Z3V6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Farnesyl-diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1312"/>
    <dbReference type="EnsemblBacteria" id="AFZ53427">
        <property type="protein sequence ID" value="AFZ53427"/>
        <property type="gene ID" value="Cyan10605_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1312"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1385"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_0_3"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="325" mass="35590" checksum="ED2C3AE7512265EA" modified="2013-03-06" version="1">MIIDQESDQSIHRNYIVNTMIKTDIKPNIDSPFNLKVYLQEKKEIVEKALDDSLPIEKPEKIYEAMRYSLLAGGKRLRPILCLAVAELLGQTEDVAMPTACALEMIHTMSLIHDDLPAMDNDDYRRGRLTNHKVYGEDIAILAGDGLLAYAFEFVAIKTSCIPSERIVKVLAILGKAVGANGLVGGQVLDLECEGKADVTADTLSFIHRRKTGALLEACVSSGAVLAGASEDDLARLSVYAQNIGLAFQIVDDILDVTATSEELGKTAGKDISAQKATYPRIWGLDTSRQKAEELIKNAIAQLDIYGDKAQPLRAIAEYIINRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W7</accession>
    <name>K9Z3W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218804.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0943"/>
    <dbReference type="EnsemblBacteria" id="AFZ53073">
        <property type="protein sequence ID" value="AFZ53073"/>
        <property type="gene ID" value="Cyan10605_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0943"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.994"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_3"/>
    <dbReference type="OMA" id="PICDGYE"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="37052" checksum="BEC0348E00D4C9FA" modified="2013-03-06" version="1">MRLSSKNLDTRLDTVYDAIVVGGGMGGLSAAIYLARYGLKCLVIEKGKGRSMWMQDLRNYVGLDPDTPGRDIINHGTKQAVDWGADHLRGYVEDVTDEGDTFAVKVKVGKKDSIYPVFRSKYLIAASGVIDVLPELDDMQNVYDYAGYTLHVCMICDGFDMWDQKAVLIVGKESQINAAFVLNWFTPYITVLTHGLCTVSDEMKQKLAEHGYPLYESAIARFVGEDHKMQGVELVDGTFIEATTGLINMGSIYHNHYLKGIEGLEWDGENLVTNEMAQTSHDRIFALGDLKKGLNQVSVAVADGTLAATQIWRNIRRQSPPRKWESNLSTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X2</accession>
    <name>K9Z3X2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218809.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0948"/>
    <dbReference type="EnsemblBacteria" id="AFZ53078">
        <property type="protein sequence ID" value="AFZ53078"/>
        <property type="gene ID" value="Cyan10605_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0948"/>
    <dbReference type="eggNOG" id="ENOG5033EGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2288624_0_0_3"/>
    <dbReference type="OMA" id="FAVIICT"/>
    <dbReference type="OrthoDB" id="2096914at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="102" mass="11557" checksum="A0AEDAAB36F9D18C" modified="2013-03-06" version="1">MNFALVRTIVRFRNVFVAILNGVITWIILIIAPLGLFTVIICTIAVFLSSVIFGLVGDFFLFMMLRQGNFNGVTGVGENRKFVDSELPSMRYSESIRKKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X9</accession>
    <name>K9Z3X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219633.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1804"/>
    <dbReference type="EnsemblBacteria" id="AFZ53906">
        <property type="protein sequence ID" value="AFZ53906"/>
        <property type="gene ID" value="Cyan10605_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1804"/>
    <dbReference type="HOGENOM" id="CLU_2435884_0_0_3"/>
    <dbReference type="OrthoDB" id="2214895at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="10912" checksum="E868DD20CE8451ED" modified="2013-03-06" version="1">MVSLNSLKNLKQGGQPTKWKNTPTKAIRIPVIFEDKILAYAQQLDLCLSSDNHNNNRSVQKFLIEIANKIDNKEKGYKSNSASQLIKDLKDLIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z473</accession>
    <name>K9Z473_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219109.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1264"/>
    <dbReference type="EnsemblBacteria" id="AFZ53380">
        <property type="protein sequence ID" value="AFZ53380"/>
        <property type="gene ID" value="Cyan10605_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1264"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1335"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_16_1_3"/>
    <dbReference type="OMA" id="LMAFGIN"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="26715" checksum="779D23F1FE9CDD2E" modified="2013-03-06" version="1">MITIRCNQHLFRNIEAIIFDKDGTLADSEKFLRELAHKRARLIDANIPGTYEPLLMAFGVEQNYLNPTGLMAVGSNKENQIVAAGYIAETGKSWFEALEIASECFENAEKAFPTRGLTSPLFAGSLEVLEMLSKKGLKIAILSADTTQGVKDFVENHQLSPYIDFIMGVDGGLSKPDPRLYLQTCQQLGVNPLNTLMVGDSQGDIAMAKNAQAGGVIGICWKYPHATHLNTADVVISDLAQIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z486</accession>
    <name>K9Z486_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219681.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53954">
        <property type="protein sequence ID" value="AFZ53954"/>
        <property type="gene ID" value="Cyan10605_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1853"/>
    <dbReference type="eggNOG" id="ENOG50343EH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347035_0_0_3"/>
    <dbReference type="OMA" id="TVEDINY"/>
    <dbReference type="OrthoDB" id="2198600at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="23650" checksum="6EB0F438B5034CBF" modified="2013-03-06" version="1">MEITLNKANKLLNKFKSERKNLRAVFNRVRYYHEDEKVEAITSVEVSLANLTPRVADEIQRMINTYRNQLQECLDIEADFFKLKEAIFVNNQRTGISEKLSQIEFLTSKVGLYDDLINEKKRNKRVTLTVEDINYELLRENLSGQDGSGKLYIQVFDVDRLAQERQEAITQMNQAEDEIARINNNTTINIDFTLASRRLLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C5</accession>
    <name>K9Z4C5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ordered locus">Cyan10605_1945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219766.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1945"/>
    <dbReference type="EnsemblBacteria" id="AFZ54041">
        <property type="protein sequence ID" value="AFZ54041"/>
        <property type="gene ID" value="Cyan10605_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1945"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2067"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_3"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="206"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="335" mass="37203" checksum="B8CCC6F3EC05A9FA" modified="2013-03-06" version="1">MRIVFFGTPEFAVTTLEKLIITDNHEIIAVVTQPDKKRGRGSQMIPSPVKQVALKNGLPIWQPSRIKKDQETLQRLKDSQADVFVVVAYGQILSSEILAIPKFGCVNVHGSILPEYRGAAPIQWSLFDGKKETGITTMLMNEGMDTGDMLLKSYTPINLFTNFNDLSVQLANQGADLLLETLEKISLGQLTPIPQNDTKATYARLISKEDYTIDWSKSALEIHNQIRGFYPNCVTIFRGQNLKITQSLPLGEIENLELPPQFQKLPNYLQGINEISGNVGEIVKTIKNFGFVVQTGNGLLLILEVQLAGKKLQSAWSFINGTRLEVGESLISEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F2</accession>
    <name>K9Z4F2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ordered locus">Cyan10605_1971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219791.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1971"/>
    <dbReference type="EnsemblBacteria" id="AFZ54066">
        <property type="protein sequence ID" value="AFZ54066"/>
        <property type="gene ID" value="Cyan10605_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1971"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2092"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_2_3"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="345" mass="38579" checksum="C70CB1ADE41FDAC3" modified="2013-03-06" version="1">MSELPCLLRVARGEVLDRPPVWMMRQAGRYMKVYRDLRDKYPSFRERSENPDLAIEISLQPWRAFQPDGVIMFSDILTPLPGMGIPFDIIESKGPIIDPPIRSLAQIEQLHPLQPEESLPFIKTILNTLRQEVANKSTVLGFVGAPWTLAAYAIEGKSSKNYAVIKSMAFSEPDMLHKLLGKIADAIATYVRYQIDCGAQVVQMFDSWAGELSPQDYETFALPYQKRVVEQVKATHPDTPLILYISGSAGVLERMGQSGVDIVSVDWTVDMAEARQRLGKEMKVQGNIDPGVLFGSPEFIRERIHDTVAKAGKGGHILNLGHGVLVGTPEDHVRVFFETAKSIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F8</accession>
    <name>K9Z4F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218987.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1136"/>
    <dbReference type="EnsemblBacteria" id="AFZ53258">
        <property type="protein sequence ID" value="AFZ53258"/>
        <property type="gene ID" value="Cyan10605_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1136"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1583181_0_0_3"/>
    <dbReference type="OMA" id="LIYGYNR"/>
    <dbReference type="OrthoDB" id="2047622at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="19006" checksum="C4223E64C12B8724" modified="2013-03-06" version="1">MKDSNNLEQIRNKANKNRWIAGVLTFFVAPVGYFYTLRYKAALISFIVYIILVGASEENETMETLLGFFAISVTVENVISINKAKNKFKELEGNTNQLTNYPSSFSGNSPDIIILKAINNRGEMTVSEIVIATELSPQIVKKTLLDLENEHLIYGYNRESDGAVVYKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G5</accession>
    <name>K9Z4G5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218997.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1146"/>
    <dbReference type="EnsemblBacteria" id="AFZ53268">
        <property type="protein sequence ID" value="AFZ53268"/>
        <property type="gene ID" value="Cyan10605_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1146"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_3_0_3"/>
    <dbReference type="OMA" id="ELECVKI"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10960" checksum="630BCF814A7B1037" modified="2013-03-06" version="1">MLTKQTNYTNLRQNLASILDEIIEDRGIVIVNRTGKEDVAMLSAQELSSMMETLYLLKSPANARKLLAAMERANELECVKIESQSVSELCEELKIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H6</accession>
    <name>K9Z4H6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219012.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1161"/>
    <dbReference type="EnsemblBacteria" id="AFZ53283">
        <property type="protein sequence ID" value="AFZ53283"/>
        <property type="gene ID" value="Cyan10605_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1161"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1228"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_1_3_3"/>
    <dbReference type="OMA" id="GHYKSVA"/>
    <dbReference type="OrthoDB" id="1858654at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13418" checksum="C94C081FE8982961" modified="2013-03-06" version="1">MDAIEVKGIRSYGYTGLFPEERSLGQWFEVDLTLWVDLQPSAKSDDIKDTLDYRQAITIVKHIIKTAKFALVEKLAEVIAQDLLEMEKVNQVRVKLSKPNPPIPDFEGSITIDITRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L8</accession>
    <name>K9Z4L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219067.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1219"/>
    <dbReference type="EnsemblBacteria" id="AFZ53338">
        <property type="protein sequence ID" value="AFZ53338"/>
        <property type="gene ID" value="Cyan10605_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1219"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439495_0_0_3"/>
    <dbReference type="OMA" id="QRWHIRV"/>
    <dbReference type="OrthoDB" id="1736558at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030816">
        <property type="entry name" value="CHP04376"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04376">
        <property type="entry name" value="TIGR04376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="22766" checksum="5DF0CE702CD8E015" modified="2013-03-06" version="1">MSIFENFTNFLESKLDEFLQNNPELNLTIIAQEIKQEKEDTIGLINKLESRRKQLELDILKLVQDIKIWCERIEKAEKANRNDLAKEAEERKNTLLSQGNFAWQEMEKVKNQILENNSKLINLENKEREINLKVKELEKAKQWTQSNSNTSNYNSYGSYRNSGFNNSNDDLEKKFRDWEVSVELEELKKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q7</accession>
    <name>K9Z4Q7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219854.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2040"/>
    <dbReference type="EnsemblBacteria" id="AFZ54129">
        <property type="protein sequence ID" value="AFZ54129"/>
        <property type="gene ID" value="Cyan10605_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2040"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2167"/>
    <dbReference type="eggNOG" id="ENOG503339X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180601_0_0_3"/>
    <dbReference type="OMA" id="DYLYPQS"/>
    <dbReference type="OrthoDB" id="2054386at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8408" checksum="771E59E7D24E93C3" modified="2013-03-06" version="1">MKNYQFAVCLNNQNYPASLELHKIYRVIPDEEAQLDGDLRIIDESGEDYLYPATYFSLIELPIDVQKSLLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S4</accession>
    <name>K9Z4S4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219137.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1293"/>
    <dbReference type="EnsemblBacteria" id="AFZ53408">
        <property type="protein sequence ID" value="AFZ53408"/>
        <property type="gene ID" value="Cyan10605_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1293"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1366"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_4_2_3"/>
    <dbReference type="OMA" id="DVGMHFL"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="203" mass="23855" checksum="F240FA32F8BA51E1" modified="2013-03-06" version="1">MSKSILTRKENFTIYDRTIDKEISFRPVTLTEDLQRIHQWMNCPHVIPFWKLNFSLEKMHAHLTKAIADPHQTLYIGSLNGVPMSYWESYWAMDDIIANYYPAEKFDQGIHLLIGDTQFLGQGLALPLLRAMTMFQFQTPETQKIITEPDARNQKMIHIFKKCGFEFQKEIDLPDKTGALMKCDRTKFEKLWDQNIFSPANFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W9</accession>
    <name>K9Z4W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219936.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2123"/>
    <dbReference type="EnsemblBacteria" id="AFZ54211">
        <property type="protein sequence ID" value="AFZ54211"/>
        <property type="gene ID" value="Cyan10605_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2123"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2258"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_2_3"/>
    <dbReference type="OMA" id="FNGSTHL"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="177"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="423" mass="48522" checksum="1B3137FF964DC55E" modified="2013-03-06" version="1">MTITLNKPQSLHLPTITTLPENNLTIIAEQIPVAAVTLNIWFNMGSAVEADNINGMAHFLEHMIFKGSRKLGLGEFERLLEARGAMTNAATSQEYTHFYFTCAPQDFVDILPLQLDLVSNPSLPPEEFTREKKVVLEEIRRSHDNPRRRVFDKMMNLCFPNLPYHRPILGTEEIIENLKLEQMQSFHHSWYQPSGMTIVAVGNLPVEELTENILNTLSLKSNQLQPPSPEYSPELPFTDIITEEYTDSNLQQARLMMLWRVPGLNHLEETIALDVLAVILGRGKLSRLFRDLRENRRLVTRISASNTTYKIQGEFYVSAQLSQENIEIVQAEIIKHIQEIQQFGVTEAELNRVKQNVASQFIFQSEKPSDRTNLYGYYYSQLRTITPALEYSEKVKHITVEKIQETAIKYLSLDAYGVLIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z506</accession>
    <name>K9Z506_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219934.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2120"/>
    <dbReference type="EnsemblBacteria" id="AFZ54209">
        <property type="protein sequence ID" value="AFZ54209"/>
        <property type="gene ID" value="Cyan10605_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2120"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2254"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_2_3"/>
    <dbReference type="OMA" id="NDEIWQT"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938623" evidence="1">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="35763" checksum="C5C25BF05EAED94E" modified="2013-03-06" version="1" precursor="true">MNIHFSKLFLCLSLISLFSWSCQSANSPPVITNQNCHQVNHSQGVTCIPNDWQTLVALDSVTTEGAIALGITPLGTTFSGISKHLEDRLTNVNNIGITGEPNIEKILALKPDLIVGIDGQENIYPHLSQIAPTALIKFSHSGHWKAVFQEFSTLIGKKELGEEVMAKYDGRIAEFRAKIGDNPPVVSVVRIYPDSINLYLRDSFVGTILTDAGLPRPESQNLSAEEARKIAGNEIQMTISKELLTKADGDVIFIWTGENDPKINEELQQKIIALQKDPLWQNLKAVQNGRVYQVPSYWIGSGLIAANLVLDDLFKYLIDEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z577</accession>
    <name>K9Z577_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin)</fullName>
            <ecNumber evidence="4">1.17.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ordered locus">Cyan10605_1795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:26119"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219624.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1795"/>
    <dbReference type="EnsemblBacteria" id="AFZ53897">
        <property type="protein sequence ID" value="AFZ53897"/>
        <property type="gene ID" value="Cyan10605_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1795"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1903"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_3"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="44583" checksum="E16DB97989DE16BC" modified="2013-03-06" version="1">MQTIDKPLRDLDNNLFDTTIHRRKTRPVKVGNVTVGGNNPVVVQSMINEDTLDVDASVAAIRRLHEIGCEIVRVTVPSLAHAKAVGEIKAKLAQTYQPVPLVADVHHNGMKIALEVAKHVDKVRINPGLYVFEKPSSDRTSYSAEEFAQIGEKIKETLEPLVVSLREQGKAMRIGVNHGSLSERMLFTYGDTPEGMVESALEFIKICESLDFRNLVISMKASRVPVMLAAYRLMVKRMDELGMDYPLHLGVTEAGDGEYGRIKSTAGIGTLLAEGIGDTIRVSLTEAPEKEIPVCYSILQALGLRKTMVEYVACPSCGRTLFNLEEVLHQVREATKHLTGLDIAVMGCIVNGPGEMADADYGYVGKQPGYISLYRGREEIKKVPETEGVKELINLIKADGKWVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z588</accession>
    <name>K9Z588_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219634.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1805"/>
    <dbReference type="EnsemblBacteria" id="AFZ53907">
        <property type="protein sequence ID" value="AFZ53907"/>
        <property type="gene ID" value="Cyan10605_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1805"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1915"/>
    <dbReference type="eggNOG" id="COG3688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101326_1_0_3"/>
    <dbReference type="OMA" id="VFDAHQV"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="182" mass="20866" checksum="29EDE24CB636BA5F" modified="2013-03-06" version="1">MNATISQAILLVDGYNVIGSWAYLQSIRDQKGLEYARNSLIESLINYSGYKELETKIVFDAHYQKTVKNEEKYSKSLSVHYTSYSETADTYIEKFCASFVRQNPESRTRIIVATSDQAQRHTVVGYGAEWMSAQKLAKEVDFTSIRQKKNLRYRPKSQGRFLFNSLDSKTQQALVKMRFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z589</accession>
    <name>K9Z589_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hopene-associated glycosyltransferase HpnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219442.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1607"/>
    <dbReference type="EnsemblBacteria" id="AFZ53715">
        <property type="protein sequence ID" value="AFZ53715"/>
        <property type="gene ID" value="Cyan10605_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1607"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1707"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_2_0_3"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="43597" checksum="8AC0ABD3618A8862" modified="2013-03-06" version="1">MIIFATLSLIIWIYLITARGNFWLCNQFLESQILKEKLNITIIIPARNEAENISICLESLLNQDYQGDFKIILVNDQSEDNTAQIAENLARKKNQTHRLIILNGKPLPQGWSGKLWAMSQGVEWARQNLSTDYFLFTDADIKHSVDNLSQLLAKAEKDNLDLVSLMVKLHCQSFWEKLLIPAFIFFFQKLYPFPLINNPRSKVSGAAGGCILIREKALTRIGGIEALKQALIDDCTLASLVKKSLPPNHGIWLGLSNNTVSLRKYPTLNPIWNMVARTAFTQLNYSTLLLIGTILGMFITYLISPIAFLYSLYTLNIPLLIISLITLLLMALSYYPTVKLYQLPIFYSFCLSAIAFLYTLMTIDSAFRHWQGKGGQWKGRVYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C1</accession>
    <name>K9Z5C1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219332.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1492"/>
    <dbReference type="EnsemblBacteria" id="AFZ53603">
        <property type="protein sequence ID" value="AFZ53603"/>
        <property type="gene ID" value="Cyan10605_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1492"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1584"/>
    <dbReference type="eggNOG" id="ENOG5031YA1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118481_0_0_3"/>
    <dbReference type="OMA" id="QELYTIR"/>
    <dbReference type="OrthoDB" id="1695288at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="16254" checksum="468238CFE6EADB22" modified="2013-03-06" version="1" precursor="true">MNQKFLSLFLLIGSLITTPIPLVGGQGSTVTKTVSTPTIPAPFGINITRNNWNTDWAVPSNNNTFRRYLVEISSNDGGPFDIRIYLKYSDQTADQFFNQEAVNIVTNKPLKIESTPRPDAQPYQVNLFVGGLESLGKTYTATVMGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C7</accession>
    <name>K9Z5C7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219487.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53760">
        <property type="protein sequence ID" value="AFZ53760"/>
        <property type="gene ID" value="Cyan10605_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1654"/>
    <dbReference type="eggNOG" id="ENOG502ZCIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828243_0_0_3"/>
    <dbReference type="OMA" id="HLSEDIC"/>
    <dbReference type="OrthoDB" id="1110541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="335" mass="40099" checksum="E0794CEB0801090A" modified="2013-03-06" version="1">MADKTSNSNLQPWWNRPLWGDKSMLEKLESIIHKPHDSIPEEVIEHHQRVFGELKILTPIAKALDNNEFNNPEFLEFVHISKLFAYEIGEYKGLKNYIALFRVAVEARNSFLKIEQIELSYRSSKQQEMYRFLLGLLEQQLNSEEFIKKLEQKQQEILPEIHSEEGKDAINVYTETLKKLARQDELGIKLMYLFKKYQLENFSLLRIISEIVQYLLKRNLLDFNDIKILVRANQDLFDQLGKVIELPIDKTREEDYARMLQYIAMKQKYQDIYIQFLRLLEVMTSWSHFYLILKEIREHYDPDEFEIPEEFNTPIPGIEIYNKYQSVITKKYKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D6</accession>
    <name>K9Z5D6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Photosystem II reaction center protein Ycf12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycf12</name>
        <name evidence="9" type="ordered locus">Cyan10605_2269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A core subunit of photosystem II (PSII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cellular thylakoid membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Ycf12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220078.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2269"/>
    <dbReference type="EnsemblBacteria" id="AFZ54354">
        <property type="protein sequence ID" value="AFZ54354"/>
        <property type="gene ID" value="Cyan10605_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2269"/>
    <dbReference type="HOGENOM" id="CLU_196761_0_1_3"/>
    <dbReference type="OrthoDB" id="2095415at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01329">
        <property type="entry name" value="PSII_Ycf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010284">
        <property type="entry name" value="PSII_Ycf12_core-subunit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05969">
        <property type="entry name" value="PSII_Ycf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="43" mass="4818" checksum="E3D04BB5CE86AA27" modified="2013-03-06" version="1">MDFISNFFSNLNLEVILQLTSVSFILIAGPVIVFILYALRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F5</accession>
    <name>K9Z5F5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysozyme</fullName>
            <ecNumber evidence="1">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 24 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220140.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2332"/>
    <dbReference type="EnsemblBacteria" id="AFZ54416">
        <property type="protein sequence ID" value="AFZ54416"/>
        <property type="gene ID" value="Cyan10605_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2332"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2476"/>
    <dbReference type="eggNOG" id="COG4678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089878_0_0_3"/>
    <dbReference type="OMA" id="GYGIETN"/>
    <dbReference type="OrthoDB" id="1505765at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="1" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="229" mass="26498" checksum="6A3D83EE0AE42497" modified="2013-03-06" version="1">MTNINRSHSFSTQIVNFFKLIILLIILTGIGNVIFREKKAEIKTAGQHLISSIYGSPPLVMEGGDPYIRALMRTISFSESNYLNPYYVIYSGEYVDDLSEHPNICMTIINGPNKGKCSTASGRYQFLNTTWAEKAAKYHPHPSKFLVWEDYSFEPEYQDKVLYNWLKDTTAWEKDIAELLREEKIDDVLRMLSPTWTSLGYGIEDNNMTKFLPKVYKKLLQEELTLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5J6</accession>
    <name>K9Z5J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microcin-processing peptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219562.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53835">
        <property type="protein sequence ID" value="AFZ53835"/>
        <property type="gene ID" value="Cyan10605_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1732"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1839"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_3"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="157"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="257"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="489" mass="53661" checksum="429B60F351C95932" modified="2013-03-06" version="1">MSPTLLISREIPNLSYHPTGDRFDLTWEKPLSTLLGIGRASGADFIEFFLEKANYISCLAEDDIITSITPRLSTGAGVRVFRGKQDCYVSTNDLTFNGLKQALEKALSILGLTIPQGTAFIPEINLEIFRDYATAKNKDIWLGNCSNMQEMGDILLSANHQLNKIANHVQSRRAAYFRDWQEVLVASSDGTFARDIRLTQSVGYNLLCADGEHRSSIGKRDGDTSNPDFLRNWNYDTVAEEVAESAGKMLYADYVESGQYPVIMANQFGGVIFHEACGHLLETTQIERKSTPFMDKKGEKIAHENLTAWDEGLTEQAFGSIDMDDEGMPPQRTLLIENGILKNFLADRAGSIRTNHPRTGSGRRQSYSFPAASRMRNTYIAPGEYTLDEVFASVDKGIYCKKMGGGSVGPTGEFNFGVDEAYLIENGKITKPLKGATLIGEAKEIMTKISMSSQDLGLAAGFCGSVSGSIYVTVGQPHIKVDSITVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L4</accession>
    <name>K9Z5L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe(3+)-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220205.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2399"/>
    <dbReference type="EnsemblBacteria" id="AFZ54481">
        <property type="protein sequence ID" value="AFZ54481"/>
        <property type="gene ID" value="Cyan10605_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2399"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2545"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="36011" checksum="F2B497BF00BF01FB" modified="2013-03-06" version="1">MQQIIAPESAITTLGLTKRFDKHIAVNDVDLQIKKGDVYGLIGPNGAGKTTLIRMLAAAETPTKGEIYLYGDRLLTDNSNSHLKKYLGYLPDDFPLYDDLTVIDYLEYFGRLYNIPASERYRRLSDVLELVQLEYKRNAEIATLSRGMKQRLSLARTIIHQPVVLLLDEPVSGLDPIARMEFRETIKQLQQAGMTILISSHVLSDLAELCTSVGIMELGFLVESTSLAQLYERLSRQLILITILEGEDKLIGELRNCPSVRAWEKLADGQRYKLEFTGNQKDSALLLKNLIIAGVAIADFHCEKEDLETIFLKLGHKQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5M1</accession>
    <name>K9Z5M1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220210.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2404"/>
    <dbReference type="EnsemblBacteria" id="AFZ54486">
        <property type="protein sequence ID" value="AFZ54486"/>
        <property type="gene ID" value="Cyan10605_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2404"/>
    <dbReference type="HOGENOM" id="CLU_2842444_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7634" checksum="12787197F1740B08" modified="2013-03-06" version="1" precursor="true">MFFGKIFIVFSLLITFLFLLILLALFGFIDGSYINHQGLGWEQTGKPILFFIFICFLLLLLFFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5N4</accession>
    <name>K9Z5N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0754 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219777.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1957"/>
    <dbReference type="EnsemblBacteria" id="AFZ54052">
        <property type="protein sequence ID" value="AFZ54052"/>
        <property type="gene ID" value="Cyan10605_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1957"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2078"/>
    <dbReference type="eggNOG" id="COG4399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042384_0_1_3"/>
    <dbReference type="OMA" id="DTIMGSL"/>
    <dbReference type="OrthoDB" id="373600at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016991">
        <property type="entry name" value="UCP032178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032178">
        <property type="entry name" value="UCP032178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="412" mass="47350" checksum="D04BDE76792BB579" modified="2013-03-06" version="1">MPIEFDYWWRIILPPVAGGVIGYFTNDLAIKMLFRPYKPIHLWGRRLPFTPGLIPRNQERLAKRVSDTIMNSLLTPEELQKLAKRLLQIDRVKSAILWLLQLALKQIKEDKQQKTAKILADILRDLFGDSIPKLLKTLSRRGDFLETQINQIFDRILLELRMNESQARQLSDWLLKVVFSPDLIRQALINFLTDRNINVIDEGFKEKTSGTYWVVANLFGVKNALSRLRSFCLDDKETANTRIQELLLSLEIRTRLKEFFLDLSLQNLPVATVKQLRETTNNAVRDYLQEKGAELLHEFSYSIDWDKISVLIVNRLQSSSVVNSSLEVISEELALILERYLEEDLEKIVTEAIPILSIDQVIIDRVNATSPEQLEVATQSIVKNELQAIVNLGGVLGVFIGALQSLILWFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z9</accession>
    <name>K9Z5Z9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="7" type="ordered locus">Cyan10605_1710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1710"/>
    <dbReference type="EnsemblBacteria" id="AFZ53813">
        <property type="protein sequence ID" value="AFZ53813"/>
        <property type="gene ID" value="Cyan10605_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1710"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1817"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_3"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="210"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="384"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="563" mass="64641" checksum="40B509EB82AA5A2E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z659</accession>
    <name>K9Z659_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.24" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219615.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1786"/>
    <dbReference type="EnsemblBacteria" id="AFZ53888">
        <property type="protein sequence ID" value="AFZ53888"/>
        <property type="gene ID" value="Cyan10605_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1786"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1894"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_3"/>
    <dbReference type="OMA" id="PFIMYLG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04189">
        <property type="entry name" value="G1P_TT_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005908">
        <property type="entry name" value="G1P_thy_trans_l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01208">
        <property type="entry name" value="rmlA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="357" mass="39411" checksum="69ABAF49EE2783CC" modified="2013-03-06" version="1">MKALILSGGKGTRLRPLTYTGAKQLVPVANKPILWYGIEAIVRAGITDIGIIISPETGEEIQKKTGDGSRFGAKITYIHQDSPDGLAHAVKIAQPFLTDSPFVMYLGDNLIAEDLDLYLQDFKEKQLDALILLRKVSNPTAFGVAKINEKGEVLELIEKPKNPPSNLALVGIYFFSSAIHEVINHLKPSARGELEITDAIQSLIENKKPVSAQELKNWWLDTGKKDDLLEANRIILDTNLTADYKYEITDNSQIIGRVKIGKNTTIINSTIRGPVIIGDNCHLENCFIGPYSSIADNVHLSEIDLEHSVILKSAEVKGIEQRIVDSVIGQRAKIHFVPKRPKALSFMIGDDSQIELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N6</accession>
    <name>K9Z6N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219935.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2121"/>
    <dbReference type="EnsemblBacteria" id="AFZ54210">
        <property type="protein sequence ID" value="AFZ54210"/>
        <property type="gene ID" value="Cyan10605_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2121"/>
    <dbReference type="eggNOG" id="COG5469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125446_2_0_3"/>
    <dbReference type="OMA" id="EKLFICK"/>
    <dbReference type="OrthoDB" id="1599787at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012863">
        <property type="entry name" value="DUF1636"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07845">
        <property type="entry name" value="DUF1636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14217" checksum="0FC0C50AD6A9717D" modified="2013-03-06" version="1">MKKEKLFICKSCQISVNQEILEGKSGGYYLHQNLIKNAENSSIEIVKSGCLWTCNQPCAVSFLASNKYTYHFVNIPPLDEKYHQALLEFGELYADSENGYILPAKVPEILQEKLLVRIPAVDTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z7</accession>
    <name>K9Z6Z7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="4 6">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-S-lactoylglutathione = glutathione + methylglyoxal</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="6">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220636.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2847"/>
    <dbReference type="EnsemblBacteria" id="AFZ54914">
        <property type="protein sequence ID" value="AFZ54914"/>
        <property type="gene ID" value="Cyan10605_2847"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2847"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3026"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_8_1_3"/>
    <dbReference type="OMA" id="NWGTESY"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="14850" checksum="E54F673AB23BADF5" modified="2013-03-06" version="1">MRILHTMLRVGNLEKSLEFYCQVLGMKLLRQKDYPNGKFTLAFVGYGDESDNTVIELTHNWDTDSYDIGNGYGHIALGVDDIYGTCEQIRSLGGKVTREPGPMKHGSTVIAFVEDPDGYKIELIQLGTQGSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z712</accession>
    <name>K9Z712_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 8">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 8">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220079.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2270"/>
    <dbReference type="EnsemblBacteria" id="AFZ54355">
        <property type="protein sequence ID" value="AFZ54355"/>
        <property type="gene ID" value="Cyan10605_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2270"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2411"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_3"/>
    <dbReference type="OMA" id="TGQLWGT"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="504" mass="58085" checksum="B0A500F081F0B2CE" modified="2013-03-06" version="1">MLNRRLSGVLLHPTSLPNAYGIGDLGNSAYRFVDFLNESDQGVWQILPLGPTGAGNSPYLAYSALAGNPLLISVDILFGDGLITQEDLDSLSNAFASHSPTHIDYDLVIQTKYPILRKAFNAFQEREKDEYTKEFIDFCQTHKDWLENYSLYMALKDYYQDKPWFQWDEDIARRKPEAIKTWQKKLAEEMLFHQFLQFSFFRQWRNLKDYANERGIHIFGDIPIYVAHDSVDVWANQSIFCLDEETGEAASMAGVPPDYFSATGQLWGNPVYNWQKLQETQFAWWIKRIKGMLEYVDVMRIDHFRGFEAYWAVPQGETTAMNGEWKEAPGDEFFAVLKQELGTLPIVAEDLGVITPEVEALRDKYGFPGMKVLHFAFDSDRDNPFLPYNYQNNCVVYTGTHDNDTTIGWFEKRSHEDKQKVIDYLGAVCDRGIHWSMIQLALSSVANWAIFPLQDLLGLGSDAKMNTPGTIENNWTWRFPEGALNLDVTGHFRYLTYLYGRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z731</accession>
    <name>K9Z731_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220275.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2471"/>
    <dbReference type="EnsemblBacteria" id="AFZ54552">
        <property type="protein sequence ID" value="AFZ54552"/>
        <property type="gene ID" value="Cyan10605_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2471"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2620"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583577_0_0_3"/>
    <dbReference type="OMA" id="SNENYHE"/>
    <dbReference type="OrthoDB" id="433196at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="207"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="468" mass="52753" checksum="E4188D7C384AB9AE" modified="2013-03-06" version="1">MAKKVIIFKIGEGSFDIGFPFSLRLSHDETRELLVETEGKLPPAPNLYKSYIDWQCSYRNLANCLRLGANQTQVTNVAIDECLGYINALEINLNQWLQDSLVQSVLFDLFPHLDQQDLIRFVIQTADVRLWQLPWYLWDVWQRYPHTEFALSKPNCQKPSRSSDINTKGKVRILAILGDRRGIDVDRDRRVLNSLPNAEVVFLDQPNLAELTPLWEQSWQILFFAGHSSSNNNTQSGLLQINPYETIDIQKLKNTLAKAVYNGLELAIFNSCDGLGLGFNLADLQLPQAIIMREPVPDEVAQEFLKFFLQAYANGETLYQAVKEAKAKIQELYHLEQKAPGSSWLPVICQNLAVNPPLWSDLTNYTSKVPNFSLQSLWKTIFSPILLWAGGAFGIAALSVTAFLLLGLFIFNTFGGRQSPILEPVRKPLIGVCECPYDIDTMGRECGNKSAYSRPGGTTPVCYRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z796</accession>
    <name>K9Z796_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220169.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2362"/>
    <dbReference type="EnsemblBacteria" id="AFZ54445">
        <property type="protein sequence ID" value="AFZ54445"/>
        <property type="gene ID" value="Cyan10605_2362"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2362"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2508"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_2_0_3"/>
    <dbReference type="OMA" id="NYGEQRF"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10882" checksum="057091A5F1974B1D" modified="2013-03-06" version="1">MKFEWDENKRQTNITKHGIDFIDARKIFDYDTVTIEDNRFNYGEQRFIAIGLLNGKIIVVVYTEISNKIRIISARKATKNEQQIYFNEIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A8</accession>
    <name>K9Z7A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220748.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2967"/>
    <dbReference type="EnsemblBacteria" id="AFZ55029">
        <property type="protein sequence ID" value="AFZ55029"/>
        <property type="gene ID" value="Cyan10605_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2967"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3158"/>
    <dbReference type="eggNOG" id="ENOG50330AI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203210_0_0_3"/>
    <dbReference type="OMA" id="MMVVYFL"/>
    <dbReference type="OrthoDB" id="2073619at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="64" mass="7078" checksum="6BD0DC8376F3A394" modified="2013-03-06" version="1">MLIPILILDIALVAWSLHLMQQAFDSREFSLMLAGTLVALAAAAMMVVYFLVHNCLAYFAHIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7C1</accession>
    <name>K9Z7C1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf_CopZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220360.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2557"/>
    <dbReference type="EnsemblBacteria" id="AFZ54637">
        <property type="protein sequence ID" value="AFZ54637"/>
        <property type="gene ID" value="Cyan10605_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2557"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115326_0_0_3"/>
    <dbReference type="OMA" id="CEVNNPQ"/>
    <dbReference type="OrthoDB" id="1244231at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040890">
        <property type="entry name" value="Znf_CopZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18423">
        <property type="entry name" value="zf_CopZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf_CopZ" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="154" mass="17809" checksum="04AC4E2E53FF7519" modified="2013-03-06" version="1">MSNCFVCQQKGKPVKIVTLQNLLKTEVLAKLNTTLNYFFCGEENCPIVYFNQQGQIFIIEELKVPVYQKDKSKNIPVCYCFNWTRESIYQKIKETQQNDVENSIKAKMKAQLCACEIKNPQGSCCLTNVHQTIDNYSSEFELLNDDEMIVLTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E8</accession>
    <name>K9Z7E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220385.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2587"/>
    <dbReference type="EnsemblBacteria" id="AFZ54662">
        <property type="protein sequence ID" value="AFZ54662"/>
        <property type="gene ID" value="Cyan10605_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2587"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2747"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_3"/>
    <dbReference type="OMA" id="SHNWIRK"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13847" checksum="F46C0680AEDC597C" modified="2013-03-06" version="1">MDIYQRLNTDRTYVNRICQQWQIVELALFGSVLRDDFNQNSDIDLLVTFAEDAKITFFDLDTIEHQFSLLFNRAVDVVTKRSIENSHNWIRKNNILNNSQIIYEQKSGSNLRFNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7N6</accession>
    <name>K9Z7N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase type I</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220137.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2329"/>
    <dbReference type="EnsemblBacteria" id="AFZ54413">
        <property type="protein sequence ID" value="AFZ54413"/>
        <property type="gene ID" value="Cyan10605_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2329"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2473"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_3"/>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="54878" checksum="F683B0A9B11AA4B7" modified="2013-03-06" version="1">MIIFWHRRDLRINDNIGLAKAYTRDKKVIGVFCLDPNILNRDDIAPARVKYLLGCLEALKTKYQKLGSDLLIFHNTPEEIIPSLAEKLKADAVYWNLDVEPFSRHRDKNVSQALKEKSIETQTFWDQLLHSPGEILSKSNQTAYTVYTPFWRNWEAQPKSSPVDSPQQLTGLNDLEKTIVKELGTINIPSLNDLGFPWDADLPLSPGEESALERLEYFCQSLIYNYECDRNYPFLDGTSQLSAALKFGAISVRTIWKKSQAELTNCNSDEARENIIAWQKEIAWREFYQHCLYFFPQLAEGAYREQFKQFPWENDEKKFQAWCEGKTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTKDLIIDWRWGEKYFMQKLYDGDLAANNGGWQWSASSGMDPKPLRIFNPASQAQKFDPEAEYIRTWLPEIRHLDTKDLVTGKISPLEASSCGYPLPIVDHSQQQREFKRLYQLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q8</accession>
    <name>K9Z7Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220485.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2689"/>
    <dbReference type="EnsemblBacteria" id="AFZ54762">
        <property type="protein sequence ID" value="AFZ54762"/>
        <property type="gene ID" value="Cyan10605_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2689"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2853"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_0_0_3"/>
    <dbReference type="OMA" id="PCFLWSG"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="262" mass="29306" checksum="2068D237D8E6CAE2" modified="2013-03-06" version="1">MIHGFIPPHRFFAYLTWQEIEKMSNKENTVIIQPIGAIEQHGYHLPLVVDSAISEGVLGKALALLSDKIPAFALPTLYYGKSNEHDGFAGTITISSQTLYTLILEMAESIYKAGFRKIVLMNSHGGQPQVMEIVARDLHQKFPDLDVFPFFTWRVPNITNELLTEEEQEWGIHAGDAETSLMLALLPQQVKMDLAVKEYPRNLAPNSLLSMEGKLPFAWLTKELSDSGVMGDATSATKEKGDRILASLAQGWVRVIEDVYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R8</accession>
    <name>K9Z7R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220944.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55226">
        <property type="protein sequence ID" value="AFZ55226"/>
        <property type="gene ID" value="Cyan10605_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3175"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3384"/>
    <dbReference type="eggNOG" id="ENOG502ZSD3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157818_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15528" checksum="CF8D9CEDD008AD8D" modified="2013-03-06" version="1">MDKKGDKISFLNIYIDSEWKEKLIDIAQQKNISLEKLIASIIGNYLGESLEHEKLEKLTQDYEKLNQRLSVLEAKNLELEKIEAKFHILEKLVENLQYQINPRHIDKGNITHSLDDEDIYDEPDEILTDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V6</accession>
    <name>K9Z7V6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="17" type="ordered locus">Cyan10605_2748</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2748"/>
    <dbReference type="EnsemblBacteria" id="AFZ54817">
        <property type="protein sequence ID" value="AFZ54817"/>
        <property type="gene ID" value="Cyan10605_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2748"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2918"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_3"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ54817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="451" mass="49276" checksum="8B7567D6457B0519" modified="2013-03-06" version="1">MTMLAVAILAAGKGTRMKSQLPKVLHKLGSKSLVERALNSCDLIKPDRSLVIIGYQGEKVKSALNHLSGVEFVEQTEQLGTGHAIQQLMPPLDDFEGDLLVLNGDVPLLRSQTIEELVKTHQENKNDATLLTANMPNPKGYGRVFCDSNNIVTQIVEDRDCNRAQKQNNRINAGVYCFNWQKLKAVLPKLSTNNDQKEYYLTEVFDYLHRVMALDVDDHLEISGINDRCQLAVAYDILQARIKEAWMMAGVTMIDPDSITIEESAQLGIDVIIEPQTHIRGNTIIGNGCHIGPACLVENSQLGKNVRALYSVISDSQVANDTKIGPFAHLRGGVVLGESCRVGNFVEIKKSNIGHKTNIAHLSYIGDATLGNQVNIGAGTITANYDGVNKHPTIIGDRTKTGSNSVFVAPVNIGEDVTIAAGSVITHDVPDDSLAIAREKQKVIKGWRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W2</accession>
    <name>K9Z7W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220545.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2753"/>
    <dbReference type="EnsemblBacteria" id="AFZ54822">
        <property type="protein sequence ID" value="AFZ54822"/>
        <property type="gene ID" value="Cyan10605_2753"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2753"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2923"/>
    <dbReference type="eggNOG" id="ENOG5031DJN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139155_0_0_3"/>
    <dbReference type="OMA" id="RATAVNW"/>
    <dbReference type="OrthoDB" id="1734836at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014952">
        <property type="entry name" value="DUF1823"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08853">
        <property type="entry name" value="DUF1823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="14012" checksum="11DCC41048C45EFF" modified="2013-03-06" version="1">MLENLPPLTNETIWDILGEKIDDETVNKLVWYHLGYRYNHESQTWDNSKVEDSWKKEYPIPPDFIANRPPNVKLTRSIPKEKKQLLKEKLGFKGYKIGEFTPRHTRRATMANWLLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z899</accession>
    <name>K9Z899_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221092.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3330"/>
    <dbReference type="EnsemblBacteria" id="AFZ55374">
        <property type="protein sequence ID" value="AFZ55374"/>
        <property type="gene ID" value="Cyan10605_3330"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3330"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3545"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_3"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="12">
        <location>
            <begin position="180"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="270"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="455" mass="51232" checksum="821842EB454AD80D" modified="2013-03-06" version="1">MSNNPRQVAFQALEDIYQNHAYTDIALDRALKNNSLSRSGLHSKSFQDRALVSELVYGIVRRKRTLDSIINQFASKKASQQPLKLRIILQLGLYQIRYLDKIPASAAVNTSVELAKKNGLSKISGVVNGILRSYLRQSADGDPLILPSDKIAYLGVKYSFPDWIVKLFIDQFSYQKTEALLDWFNNTHHIDLRTNIIKINRENLQNKLLENNIETFLLKEAQGLRLSKAVGNIGNLEEFKQGLFTIQDASAQLVTHLLNPQAGETIIDACAAPGGKTTHIAELMGDKGKVIAIDTYAKRLEKIKENATRLGLTCIEVKEGDSSELTEWENQADRVLVDVPCSGLGTLHTNPDIRWRKKPEEIEKLTRLQQKILTNASKWVKNGGILVYATCTLNQKENENIVTEFLANHPQWQLDTKNNNFLDNYSLPSKGMIKIFPPDDNMDGFFIAKLIKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B6</accession>
    <name>K9Z8B6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="15" type="ordered locus">Cyan10605_2910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220691.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2910"/>
    <dbReference type="EnsemblBacteria" id="AFZ54972">
        <property type="protein sequence ID" value="AFZ54972"/>
        <property type="gene ID" value="Cyan10605_2910"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2910"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3097"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_0_3"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="31"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="705"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="613"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="937"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="960"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="968" mass="109737" checksum="9E7E3399269587E6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E8</accession>
    <name>K9Z8E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoB--CoM heterodisulfide reductase</fullName>
            <ecNumber evidence="2">1.8.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.98.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2788"/>
    <dbReference type="EnsemblBacteria" id="AFZ54855">
        <property type="protein sequence ID" value="AFZ54855"/>
        <property type="gene ID" value="Cyan10605_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2788"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2963"/>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052147_1_0_3"/>
    <dbReference type="OMA" id="YMPGASC"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051912">
        <property type="term" value="F:CoB--CoM heterodisulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="153"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="296" mass="32652" checksum="7D4365B4261AB31B" modified="2013-03-06" version="1">MKTMIKPTTTQYAYYPGCSLHTTAREFDISTRVVMKELGIDLQELQDWSCCGGSIAASVSHDMGMAMAGRNVALAQKQNLDLLASCSGCYNKSARAMKVLKDDNEKDKIMAIMSEMGIDVKDYNIQVRNVVDVLVNDIDIASRVVKPLTGLKVACYYGCLLTRPGDITGWDSPRFPTSMDKLSRICGAEVVDFQSKTSCCGGPILVSQEERAFHLTKQILDEAKSLNADCIVLACPLCDTNLELRQADIEKKFNVTYNLPIIYITELIGLALGIKPNKLGMNKHIVSVKPILEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8M8</accession>
    <name>K9Z8M8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221237.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3484"/>
    <dbReference type="EnsemblBacteria" id="AFZ55519">
        <property type="protein sequence ID" value="AFZ55519"/>
        <property type="gene ID" value="Cyan10605_3484"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3484"/>
    <dbReference type="eggNOG" id="ENOG50346GG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2329053_0_0_3"/>
    <dbReference type="OMA" id="SPIFFTM"/>
    <dbReference type="OrthoDB" id="2172016at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11120" checksum="5F32301C0CC2989A" modified="2013-03-06" version="1">MNQTIEVNIADILVRLEGKIDKLENKIDHLTNEVNEVKINVAKLDEKLNSVESNFKTNFEGLDKRLVNLEFVYRGAGVAIIGGILLAIFRFLFPDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P7</accession>
    <name>K9Z8P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220446.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2649"/>
    <dbReference type="EnsemblBacteria" id="AFZ54723">
        <property type="protein sequence ID" value="AFZ54723"/>
        <property type="gene ID" value="Cyan10605_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2649"/>
    <dbReference type="eggNOG" id="ENOG5032VIT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2205712_0_0_3"/>
    <dbReference type="OMA" id="PYTQEMS"/>
    <dbReference type="OrthoDB" id="1831485at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12276" checksum="C82D7A21D3846C1C" modified="2013-03-06" version="1">MKQKTYTINPAKIGNQQGFRLSSAFYKENPQFAEATGEIEVLSEDTLLLRINPKNDIDEEEEEKLMMSLFLDFLSKDAVKNPEQLIPYTQEMSDEIDNLLSGVDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S1</accession>
    <name>K9Z8S1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220714.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2933"/>
    <dbReference type="EnsemblBacteria" id="AFZ54995">
        <property type="protein sequence ID" value="AFZ54995"/>
        <property type="gene ID" value="Cyan10605_2933"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2933"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3121"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_2_0_3"/>
    <dbReference type="OMA" id="FFLHARM"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="154" mass="17883" checksum="672CC5B76403BCCE" modified="2013-03-06" version="1">MQGNQEVKQQLNNVLKLKLTAINQFFLHARMCKSWGLNKLNEYEYRYSIKLMKQADKIIERVFFLEGLPNLQNLGKLLIGESVPEILANDLTIATEIADCLRSVINLCESLQDYVSRDLLTELLEETEEEIDWLESQQWLIANSGLENYLQSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U1</accession>
    <name>K9Z8U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220501.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2705"/>
    <dbReference type="EnsemblBacteria" id="AFZ54778">
        <property type="protein sequence ID" value="AFZ54778"/>
        <property type="gene ID" value="Cyan10605_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2705"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2870"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042399_4_0_3"/>
    <dbReference type="OMA" id="GRTYGIH"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22798" checksum="8B15D1A3B3252434" modified="2013-03-06" version="1" precursor="true">MKLLSYRRHLRRNFLLCLITFCFSLTGVSPSFSSESVNYIHNIQRQLLEINAPSLPPLRDSSVYLYSPDEVSNFQLVLRLKKRVVEVYEQDQVIASFPVAVGREGWETPQGEFEIIQMVENPSWQNPWTGKVIPPGPTNPLGERWIGFWTDGKNFIGFHGTPGEHLIGQAVSHGCVRMRNKDIKELFKLVSMGTPVKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8X4</accession>
    <name>K9Z8X4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220769.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2990"/>
    <dbReference type="EnsemblBacteria" id="AFZ55050">
        <property type="protein sequence ID" value="AFZ55050"/>
        <property type="gene ID" value="Cyan10605_2990"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2990"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3185"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_3"/>
    <dbReference type="OMA" id="FLRTYMY"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33899" checksum="862D56128C99E706" modified="2013-03-06" version="1">MIQATLHQLKVFETTARLGSFTKAAEELEITQPTVSSQVKQLTKTVGLPLFEQIGKQLYLTDAGKELLKTCQDVFSQLENFEMKVADLKGTKEGKLRLSVITTATYFMPRILGAFCQLYPNIDVALQVTNHEQMQQRMSNNQDDLYILSQPPEDMDLKSQPFIDNPLVMIARKDHPLASRQNISLEDLQSYPFIMRESGSGTRQAVQNLFKEHNISVKVRLELGSNEAIKQAILGDLGISVLSKHTLTTACHEDLTILDVQHFPISRHWYINYLSGKQLSVIAQTFLDFLLDRTQLMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Y5</accession>
    <name>K9Z8Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220891.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3121"/>
    <dbReference type="EnsemblBacteria" id="AFZ55172">
        <property type="protein sequence ID" value="AFZ55172"/>
        <property type="gene ID" value="Cyan10605_3121"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3121"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3327"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_2_3"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="653" mass="75129" checksum="34DFBE3F2BE55F4A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z951</accession>
    <name>K9Z951_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220854.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3078"/>
    <dbReference type="EnsemblBacteria" id="AFZ55135">
        <property type="protein sequence ID" value="AFZ55135"/>
        <property type="gene ID" value="Cyan10605_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3078"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037734_0_0_3"/>
    <dbReference type="OMA" id="NESIQAN"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="526" mass="61021" checksum="7B1BBDB0F3080439" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z964</accession>
    <name>K9Z964_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ordered locus">Cyan10605_2867</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220655.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2867"/>
    <dbReference type="EnsemblBacteria" id="AFZ54933">
        <property type="protein sequence ID" value="AFZ54933"/>
        <property type="gene ID" value="Cyan10605_2867"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2867"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3047"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_3"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="222"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="421"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="617"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="701"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="858" mass="97936" checksum="3291BA78428E797B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9F7</accession>
    <name>K9Z9F7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3154"/>
    <dbReference type="EnsemblBacteria" id="AFZ55205">
        <property type="protein sequence ID" value="AFZ55205"/>
        <property type="gene ID" value="Cyan10605_3154"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.3361"/>
    <dbReference type="eggNOG" id="COG4636">
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    </dbReference>
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    <dbReference type="OMA" id="YSMPCLL"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nuclease_put_TT1808"/>
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    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="188" mass="21422" checksum="A9BACA40AC9F8B87" modified="2013-03-06" version="1">MATLINVDSLTKLTSEAFYRLCLANPDISMERSPQGELIIMSPVGGESGNREANLITYLNVWNLKYNLGLVFSSSTVFKLPKGGDRSPDVAWVSREKWDSLTIEEKKKFPPLCPDFVIELSSESDRIKPLQEKMQEYLDSGLRLGWLINPQDREVEVYQPEKTVEIYSMPCLLLGKDVLPNFELEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9I1</accession>
    <name>K9Z9I1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220948.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3179"/>
    <dbReference type="EnsemblBacteria" id="AFZ55230">
        <property type="protein sequence ID" value="AFZ55230"/>
        <property type="gene ID" value="Cyan10605_3179"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3179"/>
    <dbReference type="eggNOG" id="ENOG5032S2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170272_0_0_3"/>
    <dbReference type="OMA" id="DYQYSAL"/>
    <dbReference type="OrthoDB" id="1954686at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042651">
        <property type="term" value="C:thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041601">
        <property type="entry name" value="FRP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18032">
        <property type="entry name" value="FRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12675" checksum="7EB2A4C12810011F" modified="2013-03-06" version="1">MSTTINTTGWSHTEIEISQKVLKKAYQRETETLMAQVRNQIEDMSDMEQLWQIHDLLSAKRYDLDGKYDTREGMLVFTFAQLLKEGWISLEELTGLDSAKLGKISSLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P1</accession>
    <name>K9Z9P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpt protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220817.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3041"/>
    <dbReference type="EnsemblBacteria" id="AFZ55098">
        <property type="protein sequence ID" value="AFZ55098"/>
        <property type="gene ID" value="Cyan10605_3041"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3041"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3237"/>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062015_0_0_3"/>
    <dbReference type="OMA" id="IIEANEH"/>
    <dbReference type="OrthoDB" id="1298097at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="306" mass="34059" checksum="8AF12DF428CE1B9B" modified="2013-03-06" version="1">MDSANNEKIVGYFIEEAKEHLETIEKGILDLESAINDEERINELFRAAHSIKGGAAMLNFTSIQKTSHRLEDAFKILRDETIEPDSTLESLFLKAYDILQDLLERLQGPFGLSEDEGEEIMKEAEPHFVELLNYIEQLVAGESPDVQKITSASVRSSTPSLTAIPSDEITMQVRQILQQMLVIFKQDATPNNRQQLQGMCDKLVKLAPAENGWQNLLKCARLAIGNPKHSYRLLAPVIIKEVKLAGDCLEVGKGSEITPSQGLEQLAHSKLPQVLVTVDPVIAAETIHKVFNPEQISKLVNLLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9Q2</accession>
    <name>K9Z9Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221170.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3410"/>
    <dbReference type="EnsemblBacteria" id="AFZ55452">
        <property type="protein sequence ID" value="AFZ55452"/>
        <property type="gene ID" value="Cyan10605_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3410"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3633"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_3"/>
    <dbReference type="OMA" id="FIGPHVY"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="160"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="369" mass="40838" checksum="28A8BAF179864A99" modified="2013-03-06" version="1" precursor="true">MNWWRRLRKNPLAKLGAVTLLLFYFMVIGADFIAPYNPYSVQENGSLLPPTTIYWRNSQRQFIGPHVYPTIQGATDLQTGDRILEIDYSKPSPLRLFPKTEPYQLFALKLPLPPKFEEREIFSGFTINRKLFGTTGEGKINLLGTDEQGRDQFSRILYGGRISLFIGIIGILISFPLGMFIGGIAGYFGGIIDSILMRLVEVLMTIPGIYLLVALAAILPPSLSSAQRFLLIVMITSFIGWSGLARVIRGQVLAIKEQEFVQSARAIGANSFYIIVKHILPQTATYIIISATLSIPSFIVAESVLSLIGLGIQQPDPSWGNLLSLATNASVLVLQPWLIFPPALLIILTVLSFNLLGDGLRDSLDPKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA19</accession>
    <name>K9ZA19_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220912.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3142"/>
    <dbReference type="EnsemblBacteria" id="AFZ55193">
        <property type="protein sequence ID" value="AFZ55193"/>
        <property type="gene ID" value="Cyan10605_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3142"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3349"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_0_3"/>
    <dbReference type="OMA" id="KTHERYA"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="436" mass="50602" checksum="49DB46926C4936E0" modified="2013-03-06" version="1">MYGSQQVLLNPDKDTKSVLEYICIEANKLYNIGLYYARQIYFKEHRYITKFELDKEIKTNLHYRALRSCVAQQTLRSVYEGMSSYKTLKSKANKGDLHFKPKLPNYRKKGLYQAVYPARWVKLAKNNQLKFTLGKQTKVWFGIDHFYLQMPSNLNYKDIKEYRIIPRNGCFYLEFVYEQKIEPISLCQDNVLGIDHGINNWLTCVSNVGTSFIVDGKQVKSMNNWYNKKVAILKENRTQGFWSKRLMRITEKRNRQMRDAVNKSARIVINHCLQNNIGTIVFGWNQGQKQEANMGKKTNQKFVVIPTARLKDRIKDLSELYSIQFIEQEESYTSKASFLDLDFIPTHGEKPEIWKSSGKRVKRGLFRTANNLYINADCNGSANIIRKKVTAKSSILSNVNLDGVSMGALIHPQRIRLWSAKIKRSNVDLSHCVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA86</accession>
    <name>K9ZA86_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="14" type="ordered locus">Cyan10605_3232</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220996.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3232"/>
    <dbReference type="EnsemblBacteria" id="AFZ55278">
        <property type="protein sequence ID" value="AFZ55278"/>
        <property type="gene ID" value="Cyan10605_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3232"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3446"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_3"/>
    <dbReference type="OMA" id="LATCNSP"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="12">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="13">
        <location>
            <begin position="155"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="312" mass="33725" checksum="7A84BCDB55EF72C6" modified="2013-03-06" version="1">MTQHPKITIIGSGAWGTTLAYLLDRANHSYTIWSRKSSQSLESVIVDTDIIISAVSMKGVRPIIEQLKQIKMKDNALIVTATKGLDFETTKTPSQILQEAFPDHPIIVLCGPNLSKEIKRGLPAATVVSSTSIESAELVQAMFASDIFRVYVNNDPIGTELGGTLKNVMAIASGVCDGLELGTNAKAALLTRALPEMIRVGTHLGASVETFFGLSGLGDLLATCDSPLSRNYQVGAGLAQGKSLEEIIEDLEGTAEGVNTATVLIKLAHQQKIPVPISYQVYLLLKGKITPQEAVQNLMARELKEEFWFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAK4</accession>
    <name>K9ZAK4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3386"/>
    <dbReference type="EnsemblBacteria" id="AFZ55428">
        <property type="protein sequence ID" value="AFZ55428"/>
        <property type="gene ID" value="Cyan10605_3386"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3386"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3604"/>
    <dbReference type="eggNOG" id="COG4398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055814_0_0_3"/>
    <dbReference type="OMA" id="HLYGYTG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016741">
        <property type="entry name" value="UCP018953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018953">
        <property type="entry name" value="UCP018953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FIST" evidence="7">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="8">
        <location>
            <begin position="244"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="414" mass="44715" checksum="7F45B0A018061F8A" modified="2013-03-06" version="1">MQWINALSINPSLEKAIDEVVDKIKSKLDGNADLGIIFISSAFASDYPRLMPILLDKLPLPCVIGCGGGGIVGMKNDYQPQEIEGNPALSLTVASLPDVEITPFHIIPDDLPDLDSPPSAWCSMIGVEIQKEPNFILLSDPFSAKINELLEGLDFAYPGAVKIGGLASTSTMGVGSGLFYYDGSNSDQLFRTEGTVGIALTGNIQVESIVAQGCRPIGETYQVTKGQRNVILEMSDREGKIDSPLNLLRELINSLSGEDQELAQYALFMGIARDEFKLELGAGDFLIRNLVGVDPKYGAIAVGDKIRTGQRIKFHLRDAKASADDLETLLATYYNNKQSLDQTIGALMFSCLGRGEGLYGKPNFDSQLFLDYVTDIPIAGFFCNGEIGPVAGNTFLHGYTSVFGIFSSKDTVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAZ9</accession>
    <name>K9ZAZ9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221275.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3525"/>
    <dbReference type="EnsemblBacteria" id="AFZ55558">
        <property type="protein sequence ID" value="AFZ55558"/>
        <property type="gene ID" value="Cyan10605_3525"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3525"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112932_1_0_3"/>
    <dbReference type="OMA" id="FTINAYP"/>
    <dbReference type="OrthoDB" id="1865810at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021256">
        <property type="entry name" value="DUF2808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10989">
        <property type="entry name" value="DUF2808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="186" mass="21315" checksum="9642A94389C12F1E" modified="2013-03-06" version="1">MKLTLKKYLSYSFFSIILFSLVLSIYKSSPRFVYAEEISFFRASPRLARTHTTFTLPNVISTYIFEIEIPQNAVNSLQKIVINQQTNMETIDFFPDQTKAFIINNNQQKINVTAINNLSDNKNELIIELEPSIPSGNTLKLEVKTRNPLYGGIYQYGVTTYPQGNNPRGLYLGIARFHFDQPGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZB35</accession>
    <name>K9ZB35_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221303.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3555"/>
    <dbReference type="EnsemblBacteria" id="AFZ55588">
        <property type="protein sequence ID" value="AFZ55588"/>
        <property type="gene ID" value="Cyan10605_3555"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3555"/>
    <dbReference type="eggNOG" id="ENOG5033G18">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132131_0_0_3"/>
    <dbReference type="OrthoDB" id="2116024at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="27938" checksum="C8CE6ED0D38AF6A8" modified="2013-03-06" version="1">MNIITENGFAVRIPEIPSRYRANCSKDYGCFVHGDTKGKSSRQAEKEGLTKGHFVEMALCWVDKKVLTFEPNYINEPFTEIWGIPVAGEMKTQFPDNASELSTFLIHRQSKDKLSALIELFSREAFTQWVSEGMNGDANEFAINKAKEAFFTNIFRFEMTQNECKYGVYYYLKSSCRKAENELENKALIIAKEIHEEQLKGLGYCTDSRLEINQEKSLLISAENKEEIEIGQLNGKAKKALTNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZB8</accession>
    <name>K9YZB8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217981.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0090"/>
    <dbReference type="EnsemblBacteria" id="AFZ52249">
        <property type="protein sequence ID" value="AFZ52249"/>
        <property type="gene ID" value="Cyan10605_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0090"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.92"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034788_0_1_3"/>
    <dbReference type="OMA" id="QFTIMPL"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="32044" checksum="E11176BDA4D5BA74" modified="2013-03-06" version="1" precursor="true">MESNFLTAIFLPLALFIIMLGMGLSLTLDDFKRVFVEPKAVIIGLIAQLFMLPIIGYFLALAFQLAPELAVGVMILATCPGGSTSNMITYLIKGNVALSITLTAITSLVTIFTIPLLINLSMTKFMGEGVTLQLPVGKTILQIAVITLIPISLGMLIHYYSPKLARVFDKGVKWLSLFFLGIIIFGLLLKEKENVSNFFVQVGGVTLTLNILTMILGYTLATISNLDQSSRKSITVEVGIQNGTLAIAIATTLLNMPNMAIPAAIYSLIMFVTSAVFGWLLGKNPILDYKKFPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZJ5</accession>
    <name>K9YZJ5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52371">
        <property type="protein sequence ID" value="AFZ52371"/>
        <property type="gene ID" value="Cyan10605_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0216"/>
    <dbReference type="eggNOG" id="COG5450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250295_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="42" mass="4814" checksum="107CE250A41EAB8F" modified="2013-03-06" version="1">MLCRLFAIMKTNIDLDEKLEKKGFAITGLRTKKELVNFALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z023</accession>
    <name>K9Z023_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="5" type="synonym">rps12</name>
        <name evidence="9" type="ordered locus">Cyan10605_0412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218287.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0412"/>
    <dbReference type="EnsemblBacteria" id="AFZ52556">
        <property type="protein sequence ID" value="AFZ52556"/>
        <property type="gene ID" value="Cyan10605_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0412"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.435"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_3"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="13831" checksum="61C56D53C18F67AA" modified="2013-03-06" version="1">MPTIQQLIRSERILSTKKTKSPALKECPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGTLDATGVKDRKQGRSKYGAKRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z056</accession>
    <name>K9Z056_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein, PhoT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218317.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0442"/>
    <dbReference type="EnsemblBacteria" id="AFZ52586">
        <property type="protein sequence ID" value="AFZ52586"/>
        <property type="gene ID" value="Cyan10605_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0442"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.468"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="AFMYMGD"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="269" mass="30010" checksum="C5C77E8C088CEF97" modified="2013-03-06" version="1">MNNLSSSDFYEDVVLRAENVDVYYGSHKAVAGVNLDIPKNNAIAFIGPSGCGKSTILRCFNRMNDLVASARIKGRITFKDKDIYAKNVDPVLVRSRIGMVFQKPNPFPKSIYENIAWGARINGYKGNMDDLVEESLRKAALWDEVKDKLRQSGLALSGGQQQRLCIARTIALQPEVILMDEPCSALDPISTLKVEESIHELKRNFTIVIVTHNMQQASRVSDYTAFFNAKSIEGGSGKLGYLVEYDQTDRIFQNPAEEATQEYVSGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0D0</accession>
    <name>K9Z0D0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218355.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0482"/>
    <dbReference type="EnsemblBacteria" id="AFZ52624">
        <property type="protein sequence ID" value="AFZ52624"/>
        <property type="gene ID" value="Cyan10605_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0482"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.510"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126578_1_1_3"/>
    <dbReference type="OMA" id="YVAFWRG"/>
    <dbReference type="OrthoDB" id="2063459at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10664" checksum="8AFF36B5DEC93FEC" modified="2013-03-06" version="1">MTKAIWKGVIVAESDNCEIVEGNSYFPPDSIKSEYFISSDTHTTCGWKGVASYYTLKVNGEENKDAAWYYPNPKEKALNIKGYVAFWRGVKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I5</accession>
    <name>K9Z0I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218422.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0550"/>
    <dbReference type="EnsemblBacteria" id="AFZ52691">
        <property type="protein sequence ID" value="AFZ52691"/>
        <property type="gene ID" value="Cyan10605_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0550"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_28_0_3"/>
    <dbReference type="OMA" id="APIGEWI"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="25996" checksum="23F86E7741068773" modified="2013-03-06" version="1">MKHIFITGVSSGLGGYLTKKLVEVGDFQITGISRNKPVYLTSEYPIQWQKFDLNQTEKINSTISKILNNQIMDALILNVGIWEKTAFSSDYSFEEIEYGEIYQLIQVNITANIELIRSILKQGFLKKGGKIIFIGSTWGLENHGGKEVVFSATKFALRGMVHSLREILKHQMISPSVLNLGYLSESEYPQPQETQIPLIDVWEAIKFLLSTSPYSCVKEIDMPGMFDSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0P3</accession>
    <name>K9Z0P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein, APE2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218450.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0580"/>
    <dbReference type="EnsemblBacteria" id="AFZ52719">
        <property type="protein sequence ID" value="AFZ52719"/>
        <property type="gene ID" value="Cyan10605_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0580"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.612"/>
    <dbReference type="eggNOG" id="COG4006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081312_0_0_3"/>
    <dbReference type="OMA" id="SAETNTY"/>
    <dbReference type="OrthoDB" id="1813188at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02619">
        <property type="entry name" value="TIGR02619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="2">
        <location>
            <begin position="59"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="35666" checksum="8C743DEAA5C47322" modified="2013-03-06" version="1">METIIMTVGTSLRTNKDDTLPPEKKRPWHNKPKSLDQSLIDNIESAIAWMKATDLELISAETKTFYHLNLREKDEIILLYSATKSGEECAKILKLFFTELGQEDVTIKQIPEVNYEIDVNGSILEKMANLLAELIKNAKGNVTLAATGGFKAQSMIMALSGNIYQVPVCYIHEQYKSLIYLPFLSSDGKVSYGNYKAELPHSTRDRKDIFNLQEGTEHHRPKTWKKAQKILSEIPWIEKIYFDKKAFSAPINNFKLSNYKTKDNCYIFWLYLYEGEKHKIGVSIETTGYNEKHLEEAMRELRERLGHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q4</accession>
    <name>K9Z0Q4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218502.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0632"/>
    <dbReference type="EnsemblBacteria" id="AFZ52771">
        <property type="protein sequence ID" value="AFZ52771"/>
        <property type="gene ID" value="Cyan10605_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0632"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.668"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_3"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="179"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="52224" checksum="A5F10B0137EB7B3E" modified="2013-03-06" version="1">MTKRTFGVIGLAVMGENLALNVESRGFPIAVYNRTASKTEEFMATKAQGKDIKPAYSLEEFVQTLERPRKILVMVKAGAPVDAVIQQLKPLLEEGDMIIDGGNSLYEDTERRTNELEPTGLGFMGMGVSGGEEGALHGPSLMPGGTASAYQELEPILTKIAAQVDDGPCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLKKGLNLSNEQLHEVFADWNQTDELNSFLIEITADIFRKKDDQTDGHLIDYILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVISGYKDERISASKELTGITGKFDGDVNEYINKIRDALYCSKMCSYAQGMALIAKASAEYDYNINLPEVARIWKGGCIIKAGFLGKINKAFSDNPSLPNLLLAPEFKQSILDRQQAWRDVLILANSLGIPIPAFSASLDYFDSYRSDRLPQNLTQAQRDYFGAHTYERTDKPRGEFFHTEWMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R8</accession>
    <name>K9Z0R8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218054.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52322">
        <property type="protein sequence ID" value="AFZ52322"/>
        <property type="gene ID" value="Cyan10605_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0165"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.173"/>
    <dbReference type="eggNOG" id="COG5611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203745_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="55" mass="6260" checksum="057605D8E8EC897D" modified="2013-03-06" version="1">MAIADGNIILRYLLNDHEKLSNKAEEILENNKIILLLPVACEVVFVLQKVYSSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0S3</accession>
    <name>K9Z0S3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">Cyan10605_0615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218485.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0615"/>
    <dbReference type="EnsemblBacteria" id="AFZ52754">
        <property type="protein sequence ID" value="AFZ52754"/>
        <property type="gene ID" value="Cyan10605_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0615"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.649"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_3_0_3"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="329" mass="36557" checksum="DF4863CBE04B5D4D" modified="2013-03-06" version="1">MYIKDIGEHQLLSIINQYCDQTINGDDGAIIAFDSDRNLVVTTDILVENVHFSDRTTPPESIGYRGVTANLSDIAAMGGMPIGITVGLSLRGDTEINWVEKLYQGMKKCLAPYNINIVGGDITKSETNTISITALGKVSASHSIYRHQAQVGDVILVTGNHGLSRAGLEILLFPEKYSHLPPQIREKVIFAHQYPKPRLEVIKYLYELCQYGYRIAGMDSSDGLADAILQICHQSKVGARLDRTSIIVDEAITTIIGRKTAFEWVLYGGEDFELVLCLPLNLAKKIQQEFGEKCQIIGQITSSLEVQIIEQQNSNLQLSLNQKKTFQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X1</accession>
    <name>K9Z0X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218540.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52809">
        <property type="protein sequence ID" value="AFZ52809"/>
        <property type="gene ID" value="Cyan10605_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0671"/>
    <dbReference type="eggNOG" id="ENOG5034201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932913_0_0_3"/>
    <dbReference type="OrthoDB" id="2163998at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="298" mass="35076" checksum="4D4046321473F7F5" modified="2013-03-06" version="1">MLKFADYVLTIHESLLNFEAEKQETYGNIEDLREFLVETDTTIEEIWDNLTETTELLLNEITTLEDNFTNEVEKMLTELDDLEVKIEDFVTENEELTVEIKEDIINLAEKINSNDQDIAEELEEFEEIVNLFNKNVQEIEPSLTENLTNTHRFLDEIILRAISHYQEVIDKESENFVRFYDDYLNNFIEENIAEIPSTLDNIISTITDVNEENKEIIEEATETLITLYSSDSGEISEEYQNLFNLIEEKLIECLNDYQEKIGDRTQEIEEKLEESMEIYKNSNDNAESLIRIFEKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z154</accession>
    <name>K9Z154_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218667.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0803"/>
    <dbReference type="EnsemblBacteria" id="AFZ52936">
        <property type="protein sequence ID" value="AFZ52936"/>
        <property type="gene ID" value="Cyan10605_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0803"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.845"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_0_3"/>
    <dbReference type="OMA" id="CLMAVGA"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="36"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="9">
        <location>
            <begin position="379"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="75"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="511" mass="56227" checksum="70EFCE9A39C16766" modified="2013-03-06" version="1">MNSKITEILPSDQYNQQLISLVHPHDWINPNPQKQYDLVVIGAGTAGLVVAAGAAGLDLGLKIALIEKHLMGGDCLNFGCVPSKAIIRSGKIIGEILKAEKLGIKTQENEIDFAYIMERMRKIRAGISHHDSAQRFKNLGIDVFFGSAHFFDQNTIEVEGLKLHYKKAVIATGAKPIIPNIEGINDVNFYTNETIFSLTKLPPSLAVMGGGAIGSELAQVFNRLGSQVTLLHKHDYILNKEDKQAREIIQNTFLQEGINLILNSQILKVELTENGKKIDYISNGQKNSITVSDILVCIGREPNIKELNLEKVGVEYDLKKGVKINDYLQTTNPRIFAAGDVCLGEKFTHTADAAARIVIKNTLFSPFGLGKAKFSDLIIPRVTYTDPEVAHVGKSPHQLVTEGLDFNTITVLMDKVDRAITDEETEGFVKIYHQKNSDKILGATIVASHAGEMISEITLAMVNNIGLNGISKVIHSYPTQAEAIKKAADAYRRTLLTPQSRRILKLLSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E8</accession>
    <name>K9Z1E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-glycerol phosphate synthase</fullName>
            <ecNumber evidence="2">2.4.1.213</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.213" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218288.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0413"/>
    <dbReference type="EnsemblBacteria" id="AFZ52557">
        <property type="protein sequence ID" value="AFZ52557"/>
        <property type="gene ID" value="Cyan10605_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0413"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.437"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_3"/>
    <dbReference type="OMA" id="YYGFSNR"/>
    <dbReference type="OrthoDB" id="556566at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033828">
        <property type="term" value="F:glucosylglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051473">
        <property type="term" value="P:glucosylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012764">
        <property type="entry name" value="Gluc_glyc_Psyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02398">
        <property type="entry name" value="gluc_glyc_Psyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="496" mass="57392" checksum="15A1A8EB6EE23EDE" modified="2013-03-06" version="1">MKSSLVILYHRQPYDEVIEDGKVVYRQKKSPNGIVPTLKGFFSYAEKGTWIAWREVDESEKEEFEPRITSDEEETNYTVLRIGLTKEQVKDFYHITSKEAFWPILHSFPYHFTYESSNWENFREVNRLFAEAACNEAADDALIWIHDYNLWLVPHYIRQIKPDARIAFFHHTPFPSVDIFNILPWREEIINSLLSCDVVGFHIPRYSENFVNVARSLLPVEIVERQPVSGHIIPVGTALAEPEMVTKLKYKNQYVKVDAFPVGTNPDFFLSVLNQPETQQRLKELEAEFEGKKLIIAAGRVDYVKGNKEMLEAFGRLLERRPDLHGNIHFIVSCVSPAAGMRVYEEAQSQIEQLVGQINGHFGRLDWTPILLFTQVIPISELLCYYKISDVCWTTPLRDGLNLVAKEYIITHQGENGVLILSEFVGAAVELANAIQTNPYSTDLMDKAIDRALAMSVEEQKERMQKMYEVVTKYDVKYWGDRLLEVFKELSHEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N3</accession>
    <name>K9Z1N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218847.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0986"/>
    <dbReference type="EnsemblBacteria" id="AFZ53116">
        <property type="protein sequence ID" value="AFZ53116"/>
        <property type="gene ID" value="Cyan10605_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0986"/>
    <dbReference type="eggNOG" id="ENOG50335IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176022_3_1_3"/>
    <dbReference type="OMA" id="INTRPTD"/>
    <dbReference type="OrthoDB" id="2089632at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="7835" checksum="90F4C013A0D02960" modified="2013-03-06" version="1">MLNNVGRSDRFFRLIFASILGYLGLFIYDGTALGLGLATASVLLTISGVFGFCFLYTVLGINTNNARESSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R7</accession>
    <name>K9Z1R7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="5" type="synonym">rpl3</name>
        <name evidence="9" type="ordered locus">Cyan10605_0525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218398.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0525"/>
    <dbReference type="EnsemblBacteria" id="AFZ52667">
        <property type="protein sequence ID" value="AFZ52667"/>
        <property type="gene ID" value="Cyan10605_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0525"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.555"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_3"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="226" mass="24382" checksum="16E2F54D6DD1835D" modified="2013-03-06" version="1">MSLGVLGTKLGMTTVFDPETGNAIPVTVIQAGPCRVTQIKTPEKDGYTALQIGYDELPDRKRTLNTKEPREINKYLTSPEAGHLATKGLPALRHLKEYRLDDVSGYELGQTIGADLFSEGQLVDVGGKTIGRGFAGYQKRHNFKRGNMTHGSKNHRLPGSTGAGTTPGRTYPGKRMAGRYGNTQIKVRKLTVVKIDSERNLILVKGSIPGKPGNLVSVTPATIVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y3</accession>
    <name>K9Z1Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218331.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0458"/>
    <dbReference type="EnsemblBacteria" id="AFZ52600">
        <property type="protein sequence ID" value="AFZ52600"/>
        <property type="gene ID" value="Cyan10605_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0458"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.484"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_3"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="39722" checksum="B8AFD1D8C97AC6CA" modified="2013-03-06" version="1">MKNQRLSTDNLPIQKNNYNKPLKIGVIGVGNMGQHHTRVLSLLKDVELVGIADVNVERGLDIASKYRVHFYENYLELLPHVEAVCIAAPTRLHHQVGLECLSRGVHVLIEKPIAASIAEAESLVNTAAASNCILQVGHIERFNPAFQELSKVLKTENLLALEAHRMSPYSQRANDVSVVLDLMIHDLDLLLELAASPVTKLSATGSRAPESQYLDYVTATLNFANGIVATVTASKVTHRKIRRIVAHCRNSLTEADFLNNEILIHRQTTANYTTDYGQILYRQDGLIEKVYTSNIEPLHAELEHFVSCVRGGNKPSVGGEQALKALRLASYIEQLALDGKVWQDSSLDLGQLNDEIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Z1</accession>
    <name>K9Z1Z1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin synthesis protein P47K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218140.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0258"/>
    <dbReference type="EnsemblBacteria" id="AFZ52408">
        <property type="protein sequence ID" value="AFZ52408"/>
        <property type="gene ID" value="Cyan10605_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0258"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.268"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_1_1_3"/>
    <dbReference type="OMA" id="GWIKELN"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="270"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="362" mass="41150" checksum="E3A836B8C0A103C9" modified="2013-03-06" version="1">MTTVESVTNSAHGIDAPKHGLPVTIITGFLGSGKTTLLNHILQNQQGVKTAVLVNEFGEIGIDNDLIIASDDSMVELSNGCICCTINTDLIDAVYRVLEREEKIDYLVVETTGVADPLPVALTFLGTELRDMTRLDSIVTVVDSENFSLDLFNSEAAYNQIAYGDIILLNKTDLVDSADVDLLEVRLRDIKKDARILRTTKSQVPLPLILSVGLFESDKYYNSDNSSHDHEHDHHDHDHEHHHHEEHNHHHHDHDHDHHHHSDHLENDGFMSVSFVSDKPFYIRKLQDFLDNKLSANVFRAKGVLWFKESPDRHIFHLSGKRFTIEDDVWKPNQTKQNKLVFIGQDIDCDRILTQLQQCLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z205</accession>
    <name>K9Z205_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218947.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1094"/>
    <dbReference type="EnsemblBacteria" id="AFZ53216">
        <property type="protein sequence ID" value="AFZ53216"/>
        <property type="gene ID" value="Cyan10605_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1094"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1158"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_3"/>
    <dbReference type="OMA" id="TRQMATM"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="69"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="404" mass="44059" checksum="09E78AF96A814883" modified="2013-03-06" version="1">MATFIVQVKDKTGNVLEERVVANSQDEARRILRKRYAAVGKIRKAGMDFDLASIEAALSKVSVKDKAIFSRQFAVLVNAGVAIVRSLSVLAEQSGNPKFKKALTTIGEDVQQGVNLSEAMAKHPDCFDRLYVSMVEAGETGGVLDEVMNRLAKLLEDVARLQNQIKSAMAYPVTVGIFAVIAFLGMTIFLIPVFAGIFDQLGAELPALTQFMVTLSDFLRSWKAIIPVGVIIGVVFAFRQYYKTPAGRLQIDTIALKAPIFGDLNEKSAVARFCRIFGTLTRSGVPILQCLEISQETIPNKVISNAIGAAKDSILEGGMLSVAISERKVFPSMAIQMMMIGEETGELDAMMMKVADFYEDEVEQAVKALTSVIEPLMMVLIAGMVGTILLSMYLPMFSIFDQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B0</accession>
    <name>K9Z2B0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="9">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219070.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1222"/>
    <dbReference type="EnsemblBacteria" id="AFZ53341">
        <property type="protein sequence ID" value="AFZ53341"/>
        <property type="gene ID" value="Cyan10605_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1222"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1289"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_2_3"/>
    <dbReference type="OMA" id="SIYWWGS"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="205" mass="23043" checksum="5D733A3A95BC4A93" modified="2013-03-06" version="1">MQSSAIENQVTVGYEAESGHHHGHPDYRMFGLVLFLVAESMIFFGLFSAYMIYYATLPEWPMDGIELELGLPAINTIILVSSSFVMHKGQSAIRNNDVKGLQFWFALTAIMGIIFLVGQGYEYMHTGFGLTDNLFASCFYVLTGFHGLHVTAGLLFTLAVLVRSRSEGHYTASKHFGVEASELYWHFVDVIWIILFVLVYLLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C0</accession>
    <name>K9Z2C0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="11" type="ordered locus">Cyan10605_1232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219080.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1232"/>
    <dbReference type="EnsemblBacteria" id="AFZ53351">
        <property type="protein sequence ID" value="AFZ53351"/>
        <property type="gene ID" value="Cyan10605_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1232"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1300"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_3"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="124"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="290" mass="31381" checksum="B4C2EAFC0B7ED4D7" modified="2013-03-06" version="1">MVAQILDGKNLAKKIQSRLQADIEKQVAIKNRRPGLAVLMVGDNPASAVYVRNKEKACQKIGMESFGKHFPDTVSQKELENVIEELNCDRNVDGILVQLPLPEKFDAVGLLHKIAPEKDADGLHPENLGKLVRGEKGLRSCTPAGVMEILADNNIDLEGKKAVVVGRSILVGKPLALMLLEKNATVTIAHSRTENLAAVTREADILIAAVGKPEMITADMVKPSAVVIDVGINRLETEDGKGYLVGDVAYEQVKEVASYITPVPGGVGPMTVAMLLQNTYDSYLNRVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D8</accession>
    <name>K9Z2D8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WbqC-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219038.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1190"/>
    <dbReference type="EnsemblBacteria" id="AFZ53309">
        <property type="protein sequence ID" value="AFZ53309"/>
        <property type="gene ID" value="Cyan10605_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1190"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1255"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079350_0_0_3"/>
    <dbReference type="OMA" id="MQPYFLP"/>
    <dbReference type="OrthoDB" id="1451657at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014985">
        <property type="entry name" value="WbqC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08889">
        <property type="entry name" value="WbqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="27452" checksum="0B90757B2D06B401" modified="2013-03-06" version="1">MKLAIMQPYFFPYIGYFQLIHAVDKFIILDDVNYINRGWINRNKIIINGEAKWFTLSLDKASQNKLIKEINISSKDVFHEKLLKTLKIFYGKAPYFNQVYDLLNKLFKIENYNLSSFLYRSLIYLKDYIGLNTEIVETSSIYPKNNLKGQDRILDICIREKTTHYINLPGGKDLYDQDFFQNNGIELSFLQPIITPYNQGIKNFIPNLSIIDVLMWNSPEDILTMVNQYELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G4</accession>
    <name>K9Z2G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219120.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1275"/>
    <dbReference type="EnsemblBacteria" id="AFZ53391">
        <property type="protein sequence ID" value="AFZ53391"/>
        <property type="gene ID" value="Cyan10605_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1275"/>
    <dbReference type="HOGENOM" id="CLU_203089_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="61" mass="7464" checksum="53700ACD8430119F" modified="2013-03-06" version="1">MFQLPNIYQQHLKNQFNLPQYLALYLLLNLLQNLKTIRLEEIARRFPYLIKLRSRVALLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I3</accession>
    <name>K9Z2I3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219140.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1296"/>
    <dbReference type="EnsemblBacteria" id="AFZ53411">
        <property type="protein sequence ID" value="AFZ53411"/>
        <property type="gene ID" value="Cyan10605_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1296"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1369"/>
    <dbReference type="eggNOG" id="COG4264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018524_1_1_3"/>
    <dbReference type="OMA" id="HPWQWWN"/>
    <dbReference type="OrthoDB" id="856726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="143"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="607" mass="70658" checksum="AC8DCB5681E24873" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N2</accession>
    <name>K9Z2N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFZ52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0855"/>
    <dbReference type="EnsemblBacteria" id="AFZ52987">
        <property type="protein sequence ID" value="AFZ52987"/>
        <property type="gene ID" value="Cyan10605_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0855"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.898"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_3"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="771" mass="84303" checksum="86D334A973D9227F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N4</accession>
    <name>K9Z2N4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218364.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0491"/>
    <dbReference type="EnsemblBacteria" id="AFZ52633">
        <property type="protein sequence ID" value="AFZ52633"/>
        <property type="gene ID" value="Cyan10605_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0491"/>
    <dbReference type="eggNOG" id="ENOG5033746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145926_0_0_3"/>
    <dbReference type="OMA" id="QEIRTEW"/>
    <dbReference type="OrthoDB" id="1969402at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13044" checksum="EFD38FC4747843C2" modified="2013-03-06" version="1">MADLSPENKRIINHLKDKLLDILNEAKKVEFLLLQRFGENLDTYDSLEQLTEISEQARTRFTKLSNLQIHIAESQPEISSSLLQFIHQAIVSSEVKIPALEQSIKEIKTDWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2N7</accession>
    <name>K9Z2N7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219195.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1352"/>
    <dbReference type="EnsemblBacteria" id="AFZ53466">
        <property type="protein sequence ID" value="AFZ53466"/>
        <property type="gene ID" value="Cyan10605_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1352"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1426"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080569_0_0_3"/>
    <dbReference type="OMA" id="NPIYHMN"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="28916" checksum="B169A885016DF277" modified="2013-03-06" version="1">MKLYEQTIAIFQRILQELLKRKRNLIFWSVFPLTILVLNSYIIAERAKIDVSLAMKISAPPSLMGAALFFSCLGGTIATIVGEREQKTLIRLFISPLMGIAYFLGILLAHSAIAFCQAILIYGLLFLLGKPIEGSFFLGLIIIILSIISYVGVGFIFGTQLAKRTEDVNSIVATFGVPLLILGGTFFPSSLFPEKMKQLAQFNPIFHMNEALIQIWGKGALFSDIKIHFWFLFVFSFIVILLGWWCYEKMLKSETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U1</accession>
    <name>K9Z2U1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4115 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219203.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1360"/>
    <dbReference type="EnsemblBacteria" id="AFZ53474">
        <property type="protein sequence ID" value="AFZ53474"/>
        <property type="gene ID" value="Cyan10605_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1360"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047530_1_1_3"/>
    <dbReference type="OMA" id="RVYLDGF"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4115" evidence="2">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="272" mass="31380" checksum="66519E0CEB6B91FF" modified="2013-03-06" version="1">MLFLRFFASKSSSETVDYDAVRKTILEEIGQTLKQKRLELNYTEELVSNQVHIPITTVKAIENADFTHLPEPIFIKQIINKYANYLKINGEELSNCFPLENNKKAQKQYLKKSSNFKFNIQLSPKYLYLIYLFLILFSIRSLSNILEFREFQETKLPQTEIVETDTSKQNQQPQAIPAVEKKEESVKSEPEELSLKLTVKQDAWVKIIVDGKPVYEGILDQGTEKEWIAKEKLTIRTGNAGGVMISLNEQKAKELGKLGQIEEVTFELPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X3</accession>
    <name>K9Z2X3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenite methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.137</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.137" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219290.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1450"/>
    <dbReference type="EnsemblBacteria" id="AFZ53561">
        <property type="protein sequence ID" value="AFZ53561"/>
        <property type="gene ID" value="Cyan10605_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1450"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1538"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_2_0_3"/>
    <dbReference type="OMA" id="MQEMNYG"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="150"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="43335" checksum="2A006F6ECBEB53A4" modified="2013-03-06" version="1">MNYNVENSVLERYELGAKEHQPSLCCPTEYDQSYLAVIPEEIIKKDYGCGDPTRYVNLGETVLDLGSGAGKNCYILAQKVGKNGQVIGVDFNDEMLNLAQKYQSEIANKIGYNNTAFVKGKIQDLQLPLSKVESYLNLNPIQNLSHLRNFEAECDRLRQEETLIKDNSIDVVISNCVLNLVKTADKKQLFAEIYRVLKKGGRAIISDIVCDEDLPSEITNDSELWSGCIAGAFREDLFLEMFAEAGFYGIEILTRQDTPWQVIDGIEFRSLTVRAYKGKEGECLERNQAIIYKGPWKKVEDDDGNTFYRGERMAVCDKTFQIMTKENSPYSSSIIGINPLEEIPLEKAKNFNEHSQIKRDPKITKGNFYQENKTTNKKQSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Y3</accession>
    <name>K9Z2Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219300.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1460"/>
    <dbReference type="EnsemblBacteria" id="AFZ53571">
        <property type="protein sequence ID" value="AFZ53571"/>
        <property type="gene ID" value="Cyan10605_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1460"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1548"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131526_1_0_3"/>
    <dbReference type="OMA" id="EQQMGRN"/>
    <dbReference type="OrthoDB" id="1941800at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008769">
        <property type="entry name" value="PhaF_PhaI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38664">
        <property type="entry name" value="PTHR38664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05597">
        <property type="entry name" value="Phasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="12532" checksum="7D8B486A8C072139" modified="2013-03-06" version="1" precursor="true">MENNDWLKQILMIGVGTTSLAAEKIKEVSEQWVKEGKINPDQAKNMVDDIMKQIQSDQGNLQAQMERQIRNVLQDLGVSRQSEVDELRGRIDRLERQVRELENKLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z380</accession>
    <name>K9Z380_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218776.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0915"/>
    <dbReference type="EnsemblBacteria" id="AFZ53045">
        <property type="protein sequence ID" value="AFZ53045"/>
        <property type="gene ID" value="Cyan10605_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0915"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.962"/>
    <dbReference type="eggNOG" id="ENOG502Z8S0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632829_0_0_3"/>
    <dbReference type="OMA" id="AINGIFW"/>
    <dbReference type="OrthoDB" id="416680at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="405" mass="47273" checksum="91D9FFE1A1273010" modified="2013-03-06" version="1">MKSLQCSTNEINRPSLTPESKTYRQLQLNYKRAKQTDHSPDLDQLAANFNYEECKNCYWNPPEFSLLYGTPFWEQASESQKIILNQLYWVAYYSQIISAEIATIFFNQTSATGLYSIEGFRLICDTLDLETRQERSHISAFRRVIDEVENKLFGERIFSFPMRSPFRETMIFADTNSFKNWWKSLQLHCFGLLSAGNTFLACQYLTVRGIRTLNGKLVQHRLSNFHLQHPNQEKSPIPAQISYHHFLDESFHFNTSTILSHDVSKCLKPPTYFERYVTNLGIRGCQKDHYHVSVAINGIFWYEPALYGAILKIMRSPLFGFSMEEAKAMLKDCFTKETEGLHRSFQTHDEAISSYQLYLEPLDFISAQNKTMKIMASNSIEKYLKTQKQALAKFFRLTQLQNSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z390</accession>
    <name>K9Z390_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1514"/>
    <dbReference type="EnsemblBacteria" id="AFZ53624">
        <property type="protein sequence ID" value="AFZ53624"/>
        <property type="gene ID" value="Cyan10605_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1514"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1607"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_4_3"/>
    <dbReference type="OMA" id="VWLADTE"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="475"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="511" mass="56528" checksum="14CC532DBE236A63" modified="2013-03-06" version="1">MIFITGRRIMILMIGWFEWAEYLSIVLTIIGLCLSLTIDNQILFIIAITFTLILSLINRFRSENRTKARIAGALSLQMRRFSAEVAEVKETIDEYIEKQKAVITPPKLASNTPKSDNQIIASLQDDLESINKSVTSIIEYIKEHKLELRLKTLEQLYQTNQNINKSQNFPSSSIKLPDKNALTKTVNYDLEAPPKIAWKCIHIINAHQQSVTDLKITKDNNYLLTTSWDQYLRLWSLETGVEIDGVEISDQGVVAVCVNNLDYINYGIATGGLDQDVKIWSLKGDKNKSWRLSLEHTMSLHEGSINGLAIANEQKILLSGSSDQTLKQWDLETGRLLSSSFDESGAIGAVAVCEKHEYVAVGGGDGVISLWQLAGENKLGALIGNMSSLDAIAVNSTGELIAGGCADGSIKIWRLPTTTFSLYLEIEPFLELKGHQGQVMDLCFSPDDKLLYSAGTDGLIKIWHPSSESELGHLKISDDNRIFSLSLSKDGTILAAGGVDGTVKVWQQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B3</accession>
    <name>K9Z3B3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd3</name>
        <name evidence="2" type="ordered locus">Cyan10605_1567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:25347"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="Rhea" id="RHEA-COMP:9872"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58570"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. DTD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219403.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1567"/>
    <dbReference type="EnsemblBacteria" id="AFZ53676">
        <property type="protein sequence ID" value="AFZ53676"/>
        <property type="gene ID" value="Cyan10605_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1567"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1664"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_3"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02048">
        <property type="entry name" value="Deacylase_DTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033665">
        <property type="entry name" value="Deacylase_DTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
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    <sequence length="258" mass="29414" checksum="65BD6C6CD246EAEB" modified="2013-03-06" version="1">MQLIDTHVHINFDVFQEDLDLVSSRWQSVGVNKLIHSCVEPQEFDRIKELSEKFPELYCSVGLHPLSANKWEGETTYQQLLEFAQSSPKVVAIGEMGLDFYKDNQPELQKEVFWKQLEIAYQLNKPVIIHCRDAATALRDILVRFNQEHGKITGVMHCWAGNPEETQWFLDLGMYVSFSGVVTFKNAKTVHQSASIVPDDRLLIETDCPFLAPTPHRGKRNEPSYVLHVAEKLAQIRGQSVEAIASQTTKNACKLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="13">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
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                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">PCC 10605</strain>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="51"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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        <location>
            <begin position="650"/>
            <end position="702"/>
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    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
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            <begin position="720"/>
            <end position="930"/>
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    </evidence>
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    </evidence>
    <sequence length="1390" mass="158744" checksum="5CA64970CD06D73C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G3</accession>
    <name>K9Z3G3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219458.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1624"/>
    <dbReference type="EnsemblBacteria" id="AFZ53731">
        <property type="protein sequence ID" value="AFZ53731"/>
        <property type="gene ID" value="Cyan10605_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1624"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1724"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_2_2_3"/>
    <dbReference type="OMA" id="MLVNKRE"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="205" mass="22301" checksum="D6CD8872C5861C24" modified="2013-03-06" version="1" precursor="true">MEIAQSVQFVAFVILSLLMIGGALGVVLFENIVYSAFLLGGVFLSISGLYILLNADFVAAAQILIYVGAINVLILFAIMLVNKTEVYQQVRGRLIRQVSTALVCVGLFALLGTMVLATPWQLSETSPAVVENTIVAIGKHFFSDYLLPFEIASVLLLMAMVGAIILARRDLIPEAQKTTEVYTTSFTLPEQPRELITTGNDNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G6</accession>
    <name>K9Z3G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219006.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1155"/>
    <dbReference type="EnsemblBacteria" id="AFZ53277">
        <property type="protein sequence ID" value="AFZ53277"/>
        <property type="gene ID" value="Cyan10605_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1155"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_4_3"/>
    <dbReference type="OMA" id="EDLIAWQ"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13564" checksum="0DDA2A1B83ECF990" modified="2013-03-06" version="1">MANYKDQFIWQKAKNLAVIVYKLTNNYPKKELYGLVSQMNRCAISIPSNIAEGYGRKSTKEYLQFLHIALGSSRELETQLIISKEVKIIENIEWIDLTIDKVNEVQALLVSTINTLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J4</accession>
    <name>K9Z3J4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219493.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1660"/>
    <dbReference type="EnsemblBacteria" id="AFZ53766">
        <property type="protein sequence ID" value="AFZ53766"/>
        <property type="gene ID" value="Cyan10605_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1660"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1762"/>
    <dbReference type="eggNOG" id="COG4735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060840_0_0_3"/>
    <dbReference type="OMA" id="WKIGAKG"/>
    <dbReference type="OrthoDB" id="1118795at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="32030" checksum="2EB81E7BF5DF7240" modified="2013-03-06" version="1">MDELREVLELASEEEIHQVTQILFCRRFNPLDYWQTPTPHDVQSLDWQTSLDYIENRFRFLAADGFTVLRGQYHSLRYKDILIRVCRYLQISYSRSMDAIALESEIFLHLLQKAWEKMSPREQYSLRQKVINSLANHPQPQPLPVSLQHDPLKILVRGGGLVAVNSLFKPWLLQKIAQQFAIHFATYQVTKNTLIKGSLATANQLQGYVSLQMAKRGMVMASARYTAVRSFFAFLTPALWACFFADLGWRAIATNYTRIIPVVFALAQIRLTRGDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3J6</accession>
    <name>K9Z3J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219498.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1666"/>
    <dbReference type="EnsemblBacteria" id="AFZ53771">
        <property type="protein sequence ID" value="AFZ53771"/>
        <property type="gene ID" value="Cyan10605_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1666"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1767"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_3"/>
    <dbReference type="OMA" id="DPHIWFD"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36494" checksum="A77EA05CE088D726" modified="2013-03-06" version="1" precursor="true">MIRFSQSQNKLLIFTVLLGFALIGCNGSSEINQSSNPESEQINNTELNNEQGKKKVLTSFTILADMAKNVAGDKLIVESITRVGAEIHGYEPTPSDLVKAESADLVLYNGMNLERWMEQFLGNVQDVPSVVLTEGIEPIPIKEGAYINKPNPHAWMSPQNALIYVENIRQAFVELDPENADTYNNNAKVYSDKIKELDRILESDLARIPEDKRYLVSCEGAFSYLARDYDLKEIYLWPINAEQQFTPKQVQSVIEKVEANNIPTIFCETTVNDEGQKQVAKTTGARFGGNLYVDSLSSEEGAVPTYLDLLEYDIRTITNGLLAGVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3X3</accession>
    <name>K9Z3X3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218999.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1148"/>
    <dbReference type="EnsemblBacteria" id="AFZ53270">
        <property type="protein sequence ID" value="AFZ53270"/>
        <property type="gene ID" value="Cyan10605_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1148"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_3"/>
    <dbReference type="OMA" id="WMTLDRE"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="226"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="449" mass="51370" checksum="43245EFDA9D24F04" modified="2013-03-06" version="1" precursor="true">MKRNRLFHQTKISLTCWYASVFSGIISLGAFFVYEAIAHAHYITINQELKTVAGTFHDTLEPLLIQPNKLEKNVKEIILDLCLIDEKCGNQSYKNRYIKGLIQQGKYYLKFYDLSGNLLGNAGVKIDNLSLNYSLEEFTSIQDNQNNNYRQISLLLHTKENKEWGYLQIGRSLEDFDRYVNNIKWLLLLGLPLLIILVIIASWYLAEKAIQPLAQSYQQMQQFGSDVAHELRTPLSAIKATIDSVFLSHNLTLEDSQETFKIIHRQNDRLINLVNDLLILTRLDSGLENTDKIKKNKINLADLINDLTEELSYLALKNQVNLTKEIKESKVFILGNEEQIYRLLANLTINAINYNQKNGQVTIFLETTKKEVIIKVIDTGIGINKEEQKLIFNRFYRINKARNREKGSCGLGLAIANAIALNHGGRIILESQENQGSIFTVYLPKIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4D5</accession>
    <name>K9Z4D5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ordered locus">Cyan10605_1335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1335"/>
    <dbReference type="EnsemblBacteria" id="AFZ53450">
        <property type="protein sequence ID" value="AFZ53450"/>
        <property type="gene ID" value="Cyan10605_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1335"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1410"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_3"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="379" mass="42337" checksum="698155CA778F8463" modified="2013-03-06" version="1" precursor="true">MLNLFKPFYPLFFASLKGNPESAHNQALHILHNIQSQRDKTWGRWIIQQLENSFCVNYPHLSQSLWNFNFAHPLGLAPGFDKNAQGAGIWSSFGFSFAELGAVTYHSQEGNPKPRMFRLPADKALLNRMGANNQGAEAIALRLQETWQKQERTIPIGINLCKSKITELNDAKEDYLKSFQVLKAHADYFVINVSSPNTPGLRSLQGGEQLEPILDTLQSHNQGEKPILVKIAPDLENEQIRSIIKVSQQYQLSGLIATNTTIKKEGLHTKILNETGKPITEEAGGISGLPLRQRSTEVIRFIYRETEGKLPIIGVGGIFDTESAWEKITAGATLLQFYSGWVYQGPWIVPDILQGLSQKLEENNLDNLSQAVGIGVNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4E4</accession>
    <name>K9Z4E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219189.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1346"/>
    <dbReference type="EnsemblBacteria" id="AFZ53460">
        <property type="protein sequence ID" value="AFZ53460"/>
        <property type="gene ID" value="Cyan10605_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1346"/>
    <dbReference type="eggNOG" id="ENOG503328M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192953_0_0_3"/>
    <dbReference type="OMA" id="HMTLQAR"/>
    <dbReference type="OrthoDB" id="2044254at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7588" checksum="65B91E28D4E1E3C1" modified="2013-03-06" version="1">MNLPSSAFHQHKKEDVSDYVAHLQIHMSLQSRNLLPQIDQVKDSRDNLLYQTQANIEKLTSRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J0</accession>
    <name>K9Z4J0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solanesyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219826.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2007"/>
    <dbReference type="EnsemblBacteria" id="AFZ54101">
        <property type="protein sequence ID" value="AFZ54101"/>
        <property type="gene ID" value="Cyan10605_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2007"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2133"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_2_3"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="35293" checksum="B3D234E62D2F1E2C" modified="2013-03-06" version="1">MTTATSIFTPVEKDLSILIDNLTSLVQAQHPILGAAAEHLFTAGGKRIRPAIVLLVSRATMKGDDLTPRHRRLAEITEMIHTASLVHDDVVDEAELRRQVATVNSLFGNRVAVLAGDFLFAQSSWYLANLDNLQVVKLLSEVIRDFAEGEIQQGLSCFDTNVSLEKYLQKSYFKTASLIANSAKAAAILSDAGEGIANQIYSYGRNIGLAFQIVDDILDFTSPTEVLGKPAGSDLACGNLTAPVLFAMEEKPSLSILIEREFSEEGDLDQALALVYDSNGIEKARDLAHQHSQLALKELQYLPSCPATDSLRELTDYVLSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4J4</accession>
    <name>K9Z4J4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">Cyan10605_1393</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219234.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1393"/>
    <dbReference type="EnsemblBacteria" id="AFZ53505">
        <property type="protein sequence ID" value="AFZ53505"/>
        <property type="gene ID" value="Cyan10605_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1393"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1471"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_3"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="356"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ53505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="432" mass="45693" checksum="6A78440857468A8B" modified="2013-03-06" version="1">MAFKIGLLGLGTVGTGTADILFNPDGRHPLLQNITISQVGVKSLEKKRNIDLPSEILTTDLEAIVTNPEIDIVVELIGGLEPARSLILKAIAHGKHVVTANKAVIARYGGEIFAAANEAKVYVLSEAAVGGGIPIVEPLKQSLGANRLENIIGIVNGTTNYILTEMTEKGSDFGQVLKVAQDLGYAEADPTADVEGYDAADKIAILASLAFGCLVKREDVYCEGITKITSSDINYAEKLGFVIKLLAIAHKVQSTTETQLQLRVHPTFVPTSHPLANVNGVNNAILVEGSPLGQVMFYGPGAGSGPTASAVVADIMNIVGVLNTDKTGDNLDSLLSCSPQGQGQISPIEEVFSRFYARFLCADVPGVIGHLGTAFGENNVSLESVVQIGFQGDLAEIVVVTHHVREGNFREAIAEIRSLNAIKNIPSIIRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N2</accession>
    <name>K9Z4N2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219087.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1240"/>
    <dbReference type="EnsemblBacteria" id="AFZ53358">
        <property type="protein sequence ID" value="AFZ53358"/>
        <property type="gene ID" value="Cyan10605_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1240"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1307"/>
    <dbReference type="eggNOG" id="ENOG5032Z2Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161929_3_0_3"/>
    <dbReference type="OMA" id="DEDIWSV"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10741" checksum="2A4B49A97B8D2FC2" modified="2013-03-06" version="1">MKSFTLPSFWNCYKTLDLKIRQQARKSYFLWKENPFHPSLHFKCINSRENIWSVRITKNYRALGIFENHSVTWFWIGSHDDYERFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4S9</accession>
    <name>K9Z4S9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219896.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2082"/>
    <dbReference type="EnsemblBacteria" id="AFZ54171">
        <property type="protein sequence ID" value="AFZ54171"/>
        <property type="gene ID" value="Cyan10605_2082"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2082"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2213"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_19_2_3"/>
    <dbReference type="OMA" id="QFFFFLY"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023222">
        <property type="entry name" value="PsbQ-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101112">
        <property type="entry name" value="SSF101112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="374" mass="41788" checksum="5ADD6E1C40031A26" modified="2013-03-06" version="1" precursor="true">MKLNWWKRLLKNAITKWRCAIATLLIAIITIINPVGLHPAQAILAQGDAITDPEAILRYALPIDNDIIRQIQGDIEKISRNLRAKRWAPVEKDVRNAAFLLKLHQDDLVQSVPEELQPKAKELVTAITEDVAKLQELVEKQDKEQVYLTRARILDNITELEEDMVTGYPFTVPEEYANLPQLLGRATVEVETTQGNLTIVVDGYSAPVTGGNFVDLVERKFYDGLPFIRAEDYYVLQTGDPEGEEVGFIDPDTNKYRAIPLEVLVKGESEPLYGFTTEDVGMYLAQPVLPFNAYGAVALARPSTDPNGGSSQFFFFKFDTEVTPPGYNLMDGRFAVFGYVTEGADVLEKLTAEDKIISAHVIEGKENLVEPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U1</accession>
    <name>K9Z4U1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219157.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1313"/>
    <dbReference type="EnsemblBacteria" id="AFZ53428">
        <property type="protein sequence ID" value="AFZ53428"/>
        <property type="gene ID" value="Cyan10605_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1313"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1386"/>
    <dbReference type="eggNOG" id="ENOG5032WJZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088685_0_0_3"/>
    <dbReference type="OMA" id="NRFRFAP"/>
    <dbReference type="OrthoDB" id="1793797at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3887" evidence="1">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="1">
        <location>
            <begin position="153"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="28557" checksum="2AC79483FB107233" modified="2013-03-06" version="1" precursor="true">MKISRFIAVGTLSVLLGGFSYQTSGYAQKLHLPFLTAQSNTQDTSAILKEKAETMIELFFAQDFEKITPYATPELRDDLSQERMERLWNRVNTKNGKFKARKQTQVIETPGSDLVFVTLEFENVTEDWIVIFNDSQEVVGVDFPNIENIETIAQRFVEDIAEGNYSEARGFLHPFLKESIFSTQIETEWNQIIAQNGDFKGIKDMRVRLGSSIDSTDIVVMDLQFNRADEQIVIIFDSSRSIIGLDFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U3</accession>
    <name>K9Z4U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219334.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1494"/>
    <dbReference type="EnsemblBacteria" id="AFZ53605">
        <property type="protein sequence ID" value="AFZ53605"/>
        <property type="gene ID" value="Cyan10605_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1494"/>
    <dbReference type="eggNOG" id="COG5350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120986_0_0_3"/>
    <dbReference type="OrthoDB" id="1382311at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="163" mass="18696" checksum="35206C3B12264BD5" modified="2013-03-06" version="1">MEIIICGVSEVNDYIDEADGVISIMNPAWRIYAPLSITEKKEENRHSVLELEFDDIWSEEDELGLEIVTKDIIYQVLNFADNFQESYKGEGKLLIHCHEGISRSSGMALTILTYLTKNIQEAINIVNEIRPQAMPNIEIIRLTDEILNLNGELLDKVFQEYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U5</accession>
    <name>K9Z4U5_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53747">
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        <property type="gene ID" value="Cyan10605_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1640"/>
    <dbReference type="HOGENOM" id="CLU_3308338_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="39" mass="4470" checksum="5CE974B012BF8D21" modified="2013-03-06" version="1">MDKSITYADILTKVLRQQSAIQPRLQNLKISSGEMEYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4U6</accession>
    <name>K9Z4U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219162.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1318"/>
    <dbReference type="EnsemblBacteria" id="AFZ53433">
        <property type="protein sequence ID" value="AFZ53433"/>
        <property type="gene ID" value="Cyan10605_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1318"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1391"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606425_0_0_3"/>
    <dbReference type="OMA" id="NHAYGTN"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="439" mass="49907" checksum="6BF5E04EFAEEE808" modified="2013-03-06" version="1">MINYKIVQEELGNIKQITEEEKIKKLSQDYYYFSPILSEKLADKTGDLVLQPTSEDEILHIAKICVKHQIPITIRGAGTGNYGQCIPLNGGIILDMTEMNKIQWIKSGIARVEAGVKMSILEREANKQGWELRMIPSTYKIATLGGFIGGGSGGIGSINYGQLRDRGNVHKVKVVTLEKEPRIIELIGDETQQINHAYGTNGIITEIEIPLAPAYNWSDFIVVFDDFMNAVKFGQVLSDSDGIIKKLVSIHAYPIPNYFLALKPYLPQGKSCAFLTIADNSFLPLQELVKEFRGEITYNPQDKQEKPLQLIEFTWNHTTFHARNIDPNLTYLQTFFWNLEQVEKMYKHFGDEVMIHLEFLRVGGKAIPAGLQLVKFTSEKRLNEIIKYHEDNGANIANPHTYILEDGGRKKVEPEQLKFKRMVDPFGLMNQGKMRAWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V1</accession>
    <name>K9Z4V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219484.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1651"/>
    <dbReference type="EnsemblBacteria" id="AFZ53757">
        <property type="protein sequence ID" value="AFZ53757"/>
        <property type="gene ID" value="Cyan10605_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1651"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012615_0_0_3"/>
    <dbReference type="OMA" id="WMIDILP"/>
    <dbReference type="OrthoDB" id="177044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="PTHR20961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="749" mass="87800" checksum="EEF0EA3FF4373463" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V4</accession>
    <name>K9Z4V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219172.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1328"/>
    <dbReference type="EnsemblBacteria" id="AFZ53443">
        <property type="protein sequence ID" value="AFZ53443"/>
        <property type="gene ID" value="Cyan10605_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1328"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1402"/>
    <dbReference type="eggNOG" id="ENOG503318T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173065_0_0_3"/>
    <dbReference type="OMA" id="QCELEDN"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="11154" checksum="508057EF0EF89BB0" modified="2013-03-06" version="1">MKDKNKIQCELEDNLREEYDLTELKNPVRGKYYQQYQKGHSVTIHYEDGTRKTEYFPPENNSDIIILDPDVKKYFPDSESVNSTLRSLIKLIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4V7</accession>
    <name>K9Z4V7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219921.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2107"/>
    <dbReference type="REBASE" id="58403">
        <property type="entry name" value="M.Cap10605ORF2107P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54196">
        <property type="protein sequence ID" value="AFZ54196"/>
        <property type="gene ID" value="Cyan10605_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2107"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2240"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_0_1_3"/>
    <dbReference type="OMA" id="AGYRKGF"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="40499" checksum="DF7C4ACFB3CB57AC" modified="2013-03-06" version="1">MTYKFIDLFAGIGGFRLGFEKAGFNCVFSSEIDIHAREMYLANFQEKPDGDIRKINHKNIPNFDVLLAGFPCQPFSIAGEKKGFNDIRGTLFFEIAKIIEYHQPKVIVLENVKHFKNHDNGKTLITVLNTLNNLGYTTSWTLLNAKDFGVPQNRERTIIIGCLEQIQFDFDKLETKPQKKLKDILENEHEKLEYLQEDEYTLIENPKQQLSGLIFAGYRNKNIRKKGTRPNTEHLSRVHKQPNRIYSSEGTHPTLSSQESSGRYYIYHNGKVRKLTLRECYRLMGFPDSFKLIGSSSKLYNRVGNSIVIPMVEEIAQQVKKQLLEKNFDSPTPLFKPRQMSLFDFNLFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z558</accession>
    <name>K9Z558_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminopeptidase P</fullName>
            <ecNumber evidence="7">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219277.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1437"/>
    <dbReference type="EnsemblBacteria" id="AFZ53548">
        <property type="protein sequence ID" value="AFZ53548"/>
        <property type="gene ID" value="Cyan10605_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1437"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1521"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_3"/>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="431" mass="48791" checksum="CD89B70D0FFF3607" modified="2013-03-06" version="1">MISPLEYKQRRQKLMSAIGKGVAVFNSAPYAVMHNDVEYVYRQDSDFYYLTGFNESSAVAVLAPNHSEHQFILFVQPKDLAKEIWTGYRVGVEGAKDLYGADAVYSIEELDEILPKYLVSGDRIYYHLGRDLNFNARIIHYWQKLTESYPKRGTGPTGIEDSNFVLHPLRMIKSPAEIEMIRKATEISVKAHKKAQEIAQPGKYEYEIQAEIEHTFRSLGGDGVAYPSIVASGANACILHYIENNRRMEAGDLLLIDAGCSYGYYNGDITRTFPVDGKFDPRQKDIYQLVLEAQLAAIEMVKPGNTYNQYHDKAVEVLVEGLKELKLLQGDSKEIIEEKKYEPFYMHRTGHWLGLDVHDVGNYKQDKENWTTFQAGHIVTVEPGIYISPYITPAEGQPEIPDYWKGIGVRIEDDVLVTESGNEVLTAGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z565</accession>
    <name>K9Z565_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hslO</name>
        <name evidence="7" type="ordered locus">Cyan10605_1581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219417.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1581"/>
    <dbReference type="EnsemblBacteria" id="AFZ53690">
        <property type="protein sequence ID" value="AFZ53690"/>
        <property type="gene ID" value="Cyan10605_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1581"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1678"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_3"/>
    <dbReference type="OMA" id="DMQCECC"/>
    <dbReference type="OrthoDB" id="1406579at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="31784" checksum="7C70B41937D7EDC1" modified="2013-03-06" version="1">MADHLIRATAADGGIRAVGVITTKAVQEARDRHKLSYVATAALGRAMSSGLLLVSNMKKEGSRVNIKIKGNGPLGGLLVDARLDGTVRGYVSNPFVELPPNEKGKLDVGGAVGKEGYLYVVRDMGYGYPYSSTVELISGEVGEDIAHYLGTSEQTPSALLVGVFVGKQGVTASGGILLQVLPKAAEDPQLVETLESRVSQLTGFTPLLRQGKTLPDIFTDLLGDFGLNIFPEIQMVRFDCGCSFDRVLGALKMLGTDELADMIEKDGGAEATCQFCGEVYHANVDHLHDLIEDLKTGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5C2</accession>
    <name>K9Z5C2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54381">
        <property type="protein sequence ID" value="AFZ54381"/>
        <property type="gene ID" value="Cyan10605_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2297"/>
    <dbReference type="eggNOG" id="ENOG502ZUG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3006624_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="56" mass="6380" checksum="C23A34717D845FCB" modified="2013-03-06" version="1">MKFCLKCKNTGRILEQRLSDYVNSFDYYPVPCPDCQVNQGTKNGRDSSPSTFSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5D8</accession>
    <name>K9Z5D8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219497.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1664"/>
    <dbReference type="EnsemblBacteria" id="AFZ53770">
        <property type="protein sequence ID" value="AFZ53770"/>
        <property type="gene ID" value="Cyan10605_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1664"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1766"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2422001_0_0_3"/>
    <dbReference type="OMA" id="DHWSWRN"/>
    <dbReference type="OrthoDB" id="1895822at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="11184" checksum="717AE5729EFD0105" modified="2013-03-06" version="1">MNELLNNNGEEQNLTRDERVKQLKNMIDTLHIAEDISRNGYLITSSELADLMDINASAVTSRGEEWSWRNWIVSRVRREGNQILWQLERVEKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L7</accession>
    <name>K9Z5L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219400.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1564"/>
    <dbReference type="EnsemblBacteria" id="AFZ53673">
        <property type="protein sequence ID" value="AFZ53673"/>
        <property type="gene ID" value="Cyan10605_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1564"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1661"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_3"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="228"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="462" mass="50468" checksum="14875CE8D29DA468" modified="2013-03-06" version="1">MKEKDYPQFLSQLIHSYKDNVDFLSIRLESSQGSNIKMRNGQIENISEGTSIGGQVRACRKGGWGFATFNDLTQIADCISDAISAAQLIGDDETVLAEVEPVVTSCKLPLTGTNPRLIHLSQKKDLVGKCDRILNSYHKDITSTTVRYSDIQQKIVLATSEGSLIEQTWIDSEMRFSATAKRGELVQTGRETTGTRRGFEDLLNLDKQIESAAKRAVNALDLPTVKGGTYTVVIDPILAGLFVHEAFGHLSEADMAYENPDLLEVMTMGRKFGGEFLQIFDGAQPEGHRGSYYYDDEGVPATTTQLIKDGVLVGRLHSRETAGKLGEKPTGNARCLNYHYPPIVRMTNTWIGKGNTPVKDLFSNIKEGVYARNWLGGMTNGEMFTFTAGEAWMIRDGIIAEPVKNVTLSGNVFKTLANIEAIGDDFYWDESGGCGKGGQNGLAVGCGSPSLRIKDVVIGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T1</accession>
    <name>K9Z5T1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1828"/>
    <dbReference type="EnsemblBacteria" id="AFZ53930">
        <property type="protein sequence ID" value="AFZ53930"/>
        <property type="gene ID" value="Cyan10605_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1828"/>
    <dbReference type="eggNOG" id="ENOG502ZM4Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212582_2_0_3"/>
    <dbReference type="OMA" id="KRTHREN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="50" mass="5825" checksum="5DA48053060B4841" modified="2013-03-06" version="1">MISQKTLENARQAHRTNLIKSLERRIEVAKAKGQIALVEQLEAEKLYYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X2</accession>
    <name>K9Z5X2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.13" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219505.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1673"/>
    <dbReference type="EnsemblBacteria" id="AFZ53778">
        <property type="protein sequence ID" value="AFZ53778"/>
        <property type="gene ID" value="Cyan10605_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1673"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1776"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_3"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="354" mass="40242" checksum="666EFFFA1222CBC9" modified="2013-03-06" version="1">MRNNKFIPVILAGGKGERFWPLSRLQRPKQFLCLDNSDESLLQTTANRLLNLAGGWQNLLVITSELLAEGVKQQLPSLPPDNILVEPTAKDTAPAVTWASLEVKRRYGEDAITAFFPADHYIGNQEQFEKIIETGIKYAQEKQGIITLGIKPDYPSTGYGYIEQGEKQEENDGISFYRVTRFTEKPDEKTAKEFIATQKYSWNSGMFIFPVEVVLEELQKHAPQILQPLQEKGKSAYTQLEKISIDYALMEKTDLAYVIRAEFGWDDLGDWNALERLLAKENNNILVGDSLNQDSENNIIYNNQSDEIVMTIGVEDLVIVREGNATLIAHKNKTQDIKKALKLLQQRENKDNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z0</accession>
    <name>K9Z5Z0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 10">Transaldolase</fullName>
            <ecNumber evidence="5 9 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tal</name>
        <name evidence="12" type="ordered locus">Cyan10605_2478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 10">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9 10">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="5 9 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220282.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2478"/>
    <dbReference type="EnsemblBacteria" id="AFZ54559">
        <property type="protein sequence ID" value="AFZ54559"/>
        <property type="gene ID" value="Cyan10605_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2478"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2627"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_3"/>
    <dbReference type="OMA" id="KFGYKTL"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="392" mass="43461" checksum="7ECCC512AE884753" modified="2013-03-06" version="1">MTNLLDQLKRYTTVVADTGDIQAIKTFTPQDATTNPSLITAAAQMSEYQSIVDDTLTEARRELGADAKVDEVVKLAIDWLAVAFGRKILDIVPGRVSTEVDARLSYDTEATIEKARYLISQYEKAGISRKRILIKIASTWEGIRAAEVLEKEGIHCNLTLLFGFHQAVACAEAGVTLISPFVGRILDWYKKETGREDFPGAEDPGVQSVTEIYNYYKKFGYKTEVMGASFRNISEICELAGCDLLTISPKLLEQLQNTEEELPLKLSVEKAQKMDIEKITVDKATFDKMHSEDRMANEKLDEGIKGFTKALETLEQLLASRLARLEGEETLAHAVDDIFHVYDLDGDGFITREEWAGADVVFDALDANHDGKITPEEMACGLGAVVYLAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z656</accession>
    <name>K9Z656_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2113"/>
    <dbReference type="EnsemblBacteria" id="AFZ54202">
        <property type="protein sequence ID" value="AFZ54202"/>
        <property type="gene ID" value="Cyan10605_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2113"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533937_0_0_3"/>
    <dbReference type="OrthoDB" id="768880at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="57282" checksum="58B746D47D9CDB1F" modified="2013-03-06" version="1">MNPEITLTWNILEEAFEIVNISSITVNPQDAIATYKSADDPNQEGDNEIPDEVWVDYTPPLPYVKNTTRNLQFNESQFLASPGEEIGVTTYVTTSDGYTWAAMSTAINAMWPYDATDYSGIASQSPYYAGNIVITPPEGVVKVTANYKGQNMKFWANEDGLTSDNPEAIKLDRYFVIDEWGNEYIMHASGQLEQSQVATAFEEAILPEGWTKETRQLSEDLILTPAEGADGSFHYLVFRDSADNTYHQTKWSDTGSLSAQIEDFPIWGGQDDNILSGDVNGEIRDDLIHGAGGNDTIIPGLGNDEIWGDADIDTVILTGDSSDYSIEEISSEEINTFTVSGFGYTKTLYDVENLQFDNETISLNNNDSLLNTQIYRFRTGEGTYLYVADEERQAILANNYNFVEEGEVFQVSMEMEDDLIPIYRFRNTNVTGAYLYVEEEERQAILQGDYGFAEEGLAFYTYGAMSEQGQEIYRFQTNPGSYIFVEKEERQNILQNYSSFTEEGIAFNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z665</accession>
    <name>K9Z665_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo-dependent nitrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219625.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1796"/>
    <dbReference type="EnsemblBacteria" id="AFZ53898">
        <property type="protein sequence ID" value="AFZ53898"/>
        <property type="gene ID" value="Cyan10605_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1796"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1904"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096128_0_0_3"/>
    <dbReference type="OMA" id="PQCPFER"/>
    <dbReference type="OrthoDB" id="1680519at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009717">
        <property type="entry name" value="Mo-dep_Nase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06967">
        <property type="entry name" value="Mo-nitro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mo-nitro_C" evidence="1">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="223" mass="25231" checksum="D69A8D206ABBEF32" modified="2013-03-06" version="1" precursor="true">MTNNERLNQYSDKQISAWLRGLLTVAYADGNFDPEEKEFIASLTQDELAPNTNLGDLEPITPQELAEALGDELDTKENFLRTAVMMAIANGVYSQSEADAVHAFQEALGLDIEALKSLEATLWNPEKEEDTSQEESHPPDLLKPVKNWLDDMNVQDPRLARFICKMVPSQCPFERDIVLFGKKIVHIPPMCKLNPLYEQLVGLRFRSLSFLADECKEDVTPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z666</accession>
    <name>K9Z666_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1975"/>
    <dbReference type="EnsemblBacteria" id="AFZ54070">
        <property type="protein sequence ID" value="AFZ54070"/>
        <property type="gene ID" value="Cyan10605_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1975"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_3"/>
    <dbReference type="OMA" id="SEYWPIT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="11">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="291"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="540"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="662" mass="76066" checksum="0EBFF8F32F952C70" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C5</accession>
    <name>K9Z6C5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219855.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2041"/>
    <dbReference type="EnsemblBacteria" id="AFZ54130">
        <property type="protein sequence ID" value="AFZ54130"/>
        <property type="gene ID" value="Cyan10605_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2041"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2168"/>
    <dbReference type="eggNOG" id="ENOG5032YN6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200298_0_0_3"/>
    <dbReference type="OMA" id="EIHWYEA"/>
    <dbReference type="OrthoDB" id="1930113at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="9137" checksum="E9B2F11DBA640417" modified="2013-03-06" version="1">MDFEIISNITEIENIAVGNSIRDLDRLRKIYGGKRWRKLKGIATIRLTNGKIRKAEIHWYEAHGIGKREIKRKRYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D4</accession>
    <name>K9Z6D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-regulated ABC transporter membrane component SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220402.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2604"/>
    <dbReference type="EnsemblBacteria" id="AFZ54679">
        <property type="protein sequence ID" value="AFZ54679"/>
        <property type="gene ID" value="Cyan10605_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2604"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2766"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_0_3"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="479" mass="52909" checksum="5A5163A3F8C3BD38" modified="2013-03-06" version="1">MSATVKNLVNQPYKYGFITDIESDTIAKGLNEDVIRLISAKKNEPEFMLEFRLKAYRQWLQMNEPKWAHVGYPAIDYQNIIYYCAPKQQKKKLNSLDEVDPTLLETFEKLGIPLSEQKRLSNVAVDAIFDSVSIATTFKEKLAEVGVIFCSISEALHEHPELVQKYLGTVVPTADNYFAALNSAVFSDGSFVFIPKGVKCPMELSTYFRINNGETGQFERTLIVAEEGASVSYLEGCTAPMYDSNQLHAAVVELVALDNAEIKYSTVQNWFAGDENGKGGIYNFVTKRGLCKGVNSKISWTQVETGSAITWKYPSCVLVGDNSVGEFYSIALTNNMQQADTGTKMVHIGKNTRSTIISKGISAGKSKNSYRGLVKMGNKATGARNYSQCDSMLIGDNAEANTFPYIQVDNNTAKLEHEASTSKIGEDQLFYFAQRGISEEDAISMLVSGFCKDVLNELPMEFAAEADKLLSLKLEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6D8</accession>
    <name>K9Z6D8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HtrA2 peptidase</fullName>
            <ecNumber evidence="3">3.4.21.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219700.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1873"/>
    <dbReference type="EnsemblBacteria" id="AFZ53973">
        <property type="protein sequence ID" value="AFZ53973"/>
        <property type="gene ID" value="Cyan10605_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1873"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1988"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_2_3"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="289"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="42708" checksum="3DCD10E7A09150C5" modified="2013-03-06" version="1" precursor="true">MVNKFIQRLTTGASLLLLGAGIGVGTNYLVNTPQLFAFTRDGENSLLKEDKVYNDDSTVSALPNNDNLNFVSQVVREVGPGVVRINASRKVATNVPPMFNDPFFRQFFGDRVPQIPDEQIQRGTGSGFIISEDGKILTNAHVVDGATEVTVNLKDGRVFEGKVLGSDPLTDLAVIQINAENLPVLEIGNSDDLVIGEWAIAIGNPLGLDNTVTTGIISATGRSSSEIGVGDKRLDFIQTDAAINPGNSGGPLLNANGEVIGINTAIIQNAQGLGFAIPINRAAQIAQTLIADGKVEHPYIGISMVSLNEQTKERLQEMNKPNLVDEEGVLIVNVMPNSPAAQAGLKSGDVIQGVEGEKIQDSTQVQKIVESRKVGSELTLNLRRDDQDLSVAVKLGILPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E7</accession>
    <name>K9Z6E7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ordered locus">Cyan10605_2061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219875.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2061"/>
    <dbReference type="EnsemblBacteria" id="AFZ54150">
        <property type="protein sequence ID" value="AFZ54150"/>
        <property type="gene ID" value="Cyan10605_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2061"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2190"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_0_0_3"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="31716" checksum="739DFD7778BA5FFD" modified="2013-03-06" version="1">MSKKIVESEYYREQEATRVRILSEALPYIQKFSGRTIVVKYGGAAMKDGTLKEYVIRDIVFLASVGVNPVVVHGGGPEINTWLTKLNIEPQFKDGLRVTDATTMDVVEMVLVGRVNKELVSMINRAGGSAVGICGKDGNLVKARSVDQENVGFVGEVTNVDISLVDALVKSGYVPIISSVAADNEGQAHNINADTFAGEIAAALGAEKLILLTDTPGILKDYHDHSTLLYKLTIQEARDLIDNDIVSGGMIPKVNCCVRSLAQGVKAAHIIDGRIPHALLLEIFTDDGIGSMIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H8</accession>
    <name>K9Z6H8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220452.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2655"/>
    <dbReference type="EnsemblBacteria" id="AFZ54729">
        <property type="protein sequence ID" value="AFZ54729"/>
        <property type="gene ID" value="Cyan10605_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2655"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_8_0_3"/>
    <dbReference type="OMA" id="VWQVYRG"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="201" mass="23147" checksum="05FEBF64A83C37FA" modified="2013-03-06" version="1">MLLGYPSNHNLKTQLRSGERRLHFYERGEEIPLIAQGIWQVNRGVVQLFKVGALGEETLLGWSQTGNFFGLWFTNLDTFQAKALSDIYLQWFSLEEIENNPNLAQKILTETVTRIRQTEELLAIATLKRIEERLLKLLNLLGAYLGETKEDKIRIKVRFTHQNLADAIGTTRVTVTRLLGDMQKQKLISLDSSRHLLLHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M6</accession>
    <name>K9Z6M6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein P-II</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PII signal transducing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219925.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2111"/>
    <dbReference type="EnsemblBacteria" id="AFZ54200">
        <property type="protein sequence ID" value="AFZ54200"/>
        <property type="gene ID" value="Cyan10605_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2111"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2245"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_3"/>
    <dbReference type="OMA" id="HQIEVNF"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12582" checksum="549C5AB59F0C06F7" modified="2013-03-06" version="1">MKKIEAIIRPFKLDEVKIALVNAGIVGMTVSEVRGFGRQKGQTERYRGSEYTVEFLQKLKLEIVVEDDQVDMVVDKVVQASRTGEIGDGKIFISPVDETIRIRTGEKNLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N0</accession>
    <name>K9Z6N0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220131.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z6N0"/>
    <dbReference type="STRING" id="755178.Cyan10605_2323"/>
    <dbReference type="EnsemblBacteria" id="AFZ54407">
        <property type="protein sequence ID" value="AFZ54407"/>
        <property type="gene ID" value="Cyan10605_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2323"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066336_3_0_3"/>
    <dbReference type="OMA" id="TNAMLMQ"/>
    <dbReference type="OrthoDB" id="1706668at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939136" evidence="1">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="17705" checksum="9D4B2D24BD42A7F3" modified="2013-03-06" version="1" precursor="true">MKVFSCIVGFILSILLLLTPNHVLAASSSAVTSTIDNKDLSQQDFSSQNLQSMEFSNVKLNGANFSNSDLRGAVFNAARLEEANFHGADLTNGFIYVTSLNRADLTDAILREAIMKRTTLKGANVDGADFTFAVLDNEQVIELCKNAQGINPVTGASTRQSLGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q5</accession>
    <name>K9Z6Q5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219960.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2149"/>
    <dbReference type="EnsemblBacteria" id="AFZ54235">
        <property type="protein sequence ID" value="AFZ54235"/>
        <property type="gene ID" value="Cyan10605_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2149"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2283"/>
    <dbReference type="eggNOG" id="COG2370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088877_1_0_3"/>
    <dbReference type="OMA" id="PFGMGES"/>
    <dbReference type="OrthoDB" id="1908275at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007038">
        <property type="entry name" value="HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04955">
        <property type="entry name" value="HupE_UreJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016919">
        <property type="entry name" value="HupE_UreJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938634" evidence="2">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="22388" checksum="A3E0C47BD5D83DDD" modified="2013-03-06" version="1" precursor="true">MKKSLSINSRLILSTILLLLIATPAYAHHAMGGETPNSFLAGLISGLAHPIIGLDHLAFVIGVGFLASFFSWGMTIPLSFVLTSILGTVVHLMNIDLPLPELIISLSVFVTGILLTRDRILPQFVVISLAVVAGIFHGYAYGESIIGAQTTPLISYLAGFAITQSFISFTAYQLGKYWQKNSSSALNLKFVGYLICGMGIIFTAGFFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V8</accession>
    <name>K9Z6V8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220201.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2395"/>
    <dbReference type="EnsemblBacteria" id="AFZ54477">
        <property type="protein sequence ID" value="AFZ54477"/>
        <property type="gene ID" value="Cyan10605_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2395"/>
    <dbReference type="HOGENOM" id="CLU_2080880_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="117" mass="13904" checksum="FDF995E8679C4D9A" modified="2013-03-06" version="1">MLKEIKEECLKENINISKYPITLDSWDVSKQLKEQLDELGFTKIIMAGKSSYVFEGEDFKGKGSEWKKRVDYQENQWGIDVPCVRKQLSNPTFGELNLWFFYSDYDKLTENNFHNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Z3</accession>
    <name>K9Z6Z3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2431"/>
    <dbReference type="EnsemblBacteria" id="AFZ54512">
        <property type="protein sequence ID" value="AFZ54512"/>
        <property type="gene ID" value="Cyan10605_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2431"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2575"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066389_0_0_3"/>
    <dbReference type="OMA" id="EWTDIND"/>
    <dbReference type="OrthoDB" id="119621at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="5">
        <location>
            <begin position="68"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="34247" checksum="E666AED23BB102A6" modified="2013-03-06" version="1">MEKPQSPDIQAQLNQARENLQRLGNAVSELVNLSPDVFNDEAIKARLQDFQQAYKEATQRLANPSFRIATIGTTSSGKSTIVNALMGRRIAPMEAGEMSGGVLTLKHSVDRTLVIEATENAVWETGEWTDINDRELYDRIQIAMHSYHEARKKKEYIAPQITAHIPLLPACDANLSGLPEGINVEFLDLPGLKSVQDKTNLAILQPLVGKAFSLVALDYMQVDEQHRQKLLTELKKVVEYLQGRTDSMIFILNRVDQRGSDDKPLDVRLQHLKKEIQEQLNLPSLKVINVDFCRYQKISYNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z715</accession>
    <name>K9Z715_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220656.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2868"/>
    <dbReference type="EnsemblBacteria" id="AFZ54934">
        <property type="protein sequence ID" value="AFZ54934"/>
        <property type="gene ID" value="Cyan10605_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2868"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3048"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_3"/>
    <dbReference type="OMA" id="RAQIVQH"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="25754" checksum="D2D75CAA7062D72D" modified="2013-03-06" version="1">MTNLEFIIRITVAFTLGASLGFERQWRQRMAGLLTNTLVSVGACLFVMLSVLIEGDSSPSRISAQVVSGIGFLAGGVILSEGLNVRGLNTAATLWCAAAIGSLTGSGFMSQAFLGAIAVLVAHLILPPLGEMINQQPLENTELYLCYQCKVICNSKHETQIRALLLQSLRENGTFKLRSMYREFLEDETKGKVKIEAEIVSKSNNDQLIEQVISRLSLEPKVISASWRLTEKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z767</accession>
    <name>K9Z767_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220708.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2927"/>
    <dbReference type="EnsemblBacteria" id="AFZ54989">
        <property type="protein sequence ID" value="AFZ54989"/>
        <property type="gene ID" value="Cyan10605_2927"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2927"/>
    <dbReference type="eggNOG" id="ENOG5032RX8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169737_1_0_3"/>
    <dbReference type="OMA" id="DWHRLKA"/>
    <dbReference type="OrthoDB" id="2034336at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045511">
        <property type="entry name" value="DUF6439"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20035">
        <property type="entry name" value="DUF6439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="93" mass="10543" checksum="2EA9FD8327ABA08D" modified="2013-03-06" version="1">MNSSLEIKSNIEDMSNLEIAQVLAQRMMISSYDWHKLKNNRKAQAAQQLTASLVYLLNDETEEALARINQAQGWLNHTVNPLPCPTHGHKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D4</accession>
    <name>K9Z7D4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-Ig-H3/fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220773.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2994"/>
    <dbReference type="EnsemblBacteria" id="AFZ55054">
        <property type="protein sequence ID" value="AFZ55054"/>
        <property type="gene ID" value="Cyan10605_2994"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2994"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3190"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_4_2_3"/>
    <dbReference type="OMA" id="YPSKNIV"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="133" mass="14104" checksum="9B36A0399BB5ABB7" modified="2013-03-06" version="1">MPTIVDIAVNNDNFKTLVAAVQAANLVDVLQSEGPFTVFAPTDDAFAKLPPGTVTTLVQNPPQLARILTYHVVAGKLMKADLEKVDSVISVEGSPITIDCSDSFEVKNATVIMADIEADNGVIHVIDNVILMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7F8</accession>
    <name>K9Z7F8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2429"/>
    <dbReference type="EnsemblBacteria" id="AFZ54510">
        <property type="protein sequence ID" value="AFZ54510"/>
        <property type="gene ID" value="Cyan10605_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2429"/>
    <dbReference type="HOGENOM" id="CLU_867964_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="320" mass="37724" checksum="AB872074412DD548" modified="2013-03-06" version="1">MTSKFTEKDRKLVIETLEKIQQTKITPVNRFRKLFKDENGLLYLVSGGTDDWHGINSNIMETLKDLEQESVFIIAKKYETRIDIFAGSLIEFIKYKDKLIKTKKNSYQFHFILTGNGLYLKEVPDFYCNEITKIDLEQNKKYLSRLKEIAKIINIEIQSNHQFTHSDIQAKLLLIGSYLNYRTYTPDQSKKSEIFNKTLGELCSEKQIPEGAIPSLSINTVKYIDVIWFDEEGYPTHAFEVEHTTDITKGLLRLYQIHKLRVKMFIIANENSRNKFDKEVNKSPFRKLNKEFIFKNYDELDSFFESVKNFSKLQQDFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G3</accession>
    <name>K9Z7G3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220803.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55084">
        <property type="protein sequence ID" value="AFZ55084"/>
        <property type="gene ID" value="Cyan10605_3025"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3025"/>
    <dbReference type="eggNOG" id="ENOG502ZI86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2786925_0_0_3"/>
    <dbReference type="OrthoDB" id="2212458at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="68" mass="7864" checksum="F175C330FF40E6D1" modified="2013-03-06" version="1">MSSIKILKAKNKDANYYRKKIGIKKKDPEKLKKLFDSLNKDLEEMAKSSNMTVEELVNILDPSNPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G4</accession>
    <name>K9Z7G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54323">
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        <property type="gene ID" value="Cyan10605_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2237"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2378"/>
    <dbReference type="eggNOG" id="COG4371">
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    </dbReference>
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    <dbReference type="OMA" id="IINLHYQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010903">
        <property type="entry name" value="DUF1517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07466">
        <property type="entry name" value="DUF1517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="22356" checksum="8DE8CCE36AF7C700" modified="2013-03-06" version="1">MSIGDRINEFIGKTRYVVSRIFVHLEGEEVAPFLGILNQNARRAVDADGEMDTMGECLVNICEGLLQYEFYWKSASNEGDVFWNEGDAGDYVTELFTDSAQRYLSQPDLEDDEENDGLSLPVTDNIIVMITVAFEGEVPEIETDLAQRDSLKDGLKALISLHYKQRYRAIAIHFSPARLGEQLNSEQILINFSELIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L7</accession>
    <name>K9Z7L7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_3088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3088"/>
    <dbReference type="EnsemblBacteria" id="AFZ55144">
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    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3088"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3290"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11809" checksum="F247FBB5237004FA" modified="2013-03-06" version="1">MINIPTHRQPTHPGEMLLKEFLEPMGISQRELADKIRVPYQRVNEIVNCRRGISPSTALRLAKFFGTSADFWLNLQLRWDLFHTQTKEKEVLAQIKEYIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S6</accession>
    <name>K9Z7S6_CYAAP</name>
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        <recommendedName>
            <fullName evidence="2">Cellulase</fullName>
            <ecNumber evidence="2">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="2"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFZ54640">
        <property type="protein sequence ID" value="AFZ54640"/>
        <property type="gene ID" value="Cyan10605_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2560"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309666_0_0_3"/>
    <dbReference type="OrthoDB" id="1691at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CalX-like_sf"/>
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        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
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        <property type="entry name" value="Glyco_hydro_5"/>
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    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="222"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="829"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="951" mass="105000" checksum="266B75D9E4D8FB95" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S9</accession>
    <name>K9Z7S9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220510.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2714"/>
    <dbReference type="EnsemblBacteria" id="AFZ54787">
        <property type="protein sequence ID" value="AFZ54787"/>
        <property type="gene ID" value="Cyan10605_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2714"/>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111097_0_0_3"/>
    <dbReference type="OMA" id="WIEEDQA"/>
    <dbReference type="OrthoDB" id="1911206at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="21572" checksum="F531ECEB9462C961" modified="2013-03-06" version="1">MSNLFTFILLKNLKNIYSHKLSQDPTFCLKNEKWEEGFSILEVLVTILVITGFVLGSLQATVLATLLRVQAQDKQEATNWVQQDLELIRYQAFILDNPTETSGLTPSQANACDNSKYGTRLQDFIDGTYPNTSDIDINGKSYDVARAYTAPENILQVSYTISYDSTHPRYKSGGDNVVTTLSTEVLPNAALSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T3</accession>
    <name>K9Z7T3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Forkhead-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2720"/>
    <dbReference type="EnsemblBacteria" id="AFZ54792">
        <property type="protein sequence ID" value="AFZ54792"/>
        <property type="gene ID" value="Cyan10605_2720"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2720"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2886"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128707_0_0_3"/>
    <dbReference type="OMA" id="YYRIVDG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="167" mass="19094" checksum="A11FAB773D464CFC" modified="2013-03-06" version="1">MQVKMILSNSIINDLPREGSTMTKHPAQPHKAHILIVEDDKGRRELLLRKSKYTIGRAQQCDIRIHSPFVSRYHATLIRQFDNQGYIYYQICDGDGKSNFSANGILVNGKKIANQELKHGDKVIFGPQVSITYQHCQRDIFPSLPPDDPFDITLIDPAMMVSEWEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T9</accession>
    <name>K9Z7T9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensin subunit ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220373.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2572"/>
    <dbReference type="EnsemblBacteria" id="AFZ54650">
        <property type="protein sequence ID" value="AFZ54650"/>
        <property type="gene ID" value="Cyan10605_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2572"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2732"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070251_1_0_3"/>
    <dbReference type="OMA" id="GEIDPWD"/>
    <dbReference type="OrthoDB" id="909213at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="259" mass="29688" checksum="0D125BC466705B0A" modified="2013-03-06" version="1">MVLTKSPASEAIEQLIELAQTGEIDPWDVKVIEIIDRFLAELGINDSDNLSVQETDLSQSGQVMLWASKLVLLKAETLARISELNPEDEESAETNIEDNLELETKRYQINELDKKIKRRTSALPVAKRKVTLGEFIAQLQSIEKELQGKSKTIDHNLPLNKTKRGYTRKQALKTITDLAHNENLTELAEQINNFLRDNLITVNENKIKLEQLISHWQSHKQETKSDKVGVFWALLLLSSQSKVELHQQEFYQDIDVYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z861</accession>
    <name>K9Z861_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221052.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3288"/>
    <dbReference type="EnsemblBacteria" id="AFZ55334">
        <property type="protein sequence ID" value="AFZ55334"/>
        <property type="gene ID" value="Cyan10605_3288"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3288"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3503"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_2_0_3"/>
    <dbReference type="OMA" id="ICRGQLR"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="56323" checksum="1DC295E4DAABB1FD" modified="2013-03-06" version="1">MELVILFLILSAIGYVAIKKSVGKLTKTPIWLLWLALMSPPFIWVGWYLANGNQSSMPRSLILMPLILSPLVYLWLIEIGRPKNHKIEQELSTPESSEDNNSTTPIILNTDENHQQALEKSTVKVKPINSEEEKALRDCFPWGVYYLQKVDYLPQGVLCLGKLMTAPEKAYTTIKANLEKVFHDRFLIIFQETLQGQPFFALIPNPNSQAEKEKQKEEEKLTRPLMALGLLLLTFVTTTIIGAEISGVTTTELETHPELVLQGLPYSLSLIAILGVHELSHYLFAVYYQIKTTLPYFIPIPFFLGTFGAFISIRSPMPNRKAVFDVAIAGPIGGFLVALPVLVWGLAYSDIVPLADDSSMLSFQALDPRFSLLLATISKLVLGSKLVAEKAIALHPAAVAGYIGIIVTALNLVPVGQLDGGHIVHAMFGQGKALVIGQITRLLMILLAFVRGEFLIWAIILMFMPIADQPALNDVTELDNGRDFLGLVAIALLVAILLPLPPTLAQWLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E0</accession>
    <name>K9Z8E0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221137.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3377"/>
    <dbReference type="EnsemblBacteria" id="AFZ55419">
        <property type="protein sequence ID" value="AFZ55419"/>
        <property type="gene ID" value="Cyan10605_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3377"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3595"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_3"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="262" mass="29485" checksum="4FEBDF356CFABF78" modified="2013-03-06" version="1">MLISVQNPLVKQVRKLHNSKERHRQNLHLLEGTNLISVALEVSYPLVTVLTTELWQKKNPFLWEKLQSQGERVETVSEEVMTKLATTVNPDGVVATAKRDSVVSHPRQNLQLGLILDRIQDPGNLGTIIRSSVAMGVDFIWLSRDCVDLDNPKVMRASVGEWFKIKAKVEDNLSLLITEYQEKGYQIIATDLQGDIKPWQVDLTAPTIILMGNESRGLSANLKNLATHKLKIPLFNDVESLNVGIASSLILHERMRQIEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E9</accession>
    <name>K9Z8E9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">Cyan10605_3387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221147.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3387"/>
    <dbReference type="EnsemblBacteria" id="AFZ55429">
        <property type="protein sequence ID" value="AFZ55429"/>
        <property type="gene ID" value="Cyan10605_3387"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3387"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3606"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_3"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="343" mass="36974" checksum="9F784EB7FBB27C2D" modified="2013-03-06" version="1">MGLFELFSESQDMGIDLGTANTLIYMPGKDIVLDEPSVIAIDEQTKEAIAVGKEAQRMLGRTPKNVRTIRPLKDGVITDVKETEMMLKEFIKKVRGNSNLTRSRIIIGVPSGITSVERRAIEEAMETSGAIDNIEFIDEPVAAAIGAGLPVDEPVGSMIVDIGGGTTDVAVLSLQGIVLSDSVRIAGDEITESIKRHLKRNYNVIVGERSAEQLKTEIGSAYPMDDEPQGMEIRGLNVVSGLPKTVNITTVEIRECIADTVGLIVDAIKKTLEQTPPELAGDIIDRGIMLAGGGALLRGLDSLIANETGIITHVAPNPLRCVVYGTGKVLEEYERLNRSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K6</accession>
    <name>K9Z8K6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220647.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2859"/>
    <dbReference type="EnsemblBacteria" id="AFZ54925">
        <property type="protein sequence ID" value="AFZ54925"/>
        <property type="gene ID" value="Cyan10605_2859"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2859"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3039"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929570_0_0_3"/>
    <dbReference type="OMA" id="RYLLLEM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="295" mass="33093" checksum="93CD42FAFCA4342B" modified="2013-03-06" version="1">MSNHVYQILLVEDNTDNAQLIENLLSSAHHSPLAEGSNFCLCCVQNLAGALQVIKEKDFEAIILDLTLPDGKGFESLLKLKENAPDTPIIIQTDSTDEAVIVRAFQMGANGYLRKIDLDCNSLVYAIRLAIERQQYVERLSALKQQKQQQEEFAGLENLAQSIQPSITARMFASSALKDSIPDVFSQLTVKYGHLLDLSLEERALKVDYNIAEQLRQLAAKLGFFKASPRDVVDIHTKALKERCKNVNLAKVQAYVDEGRLRLLELMGYLTSYYRKYYIGLSNLTILSSSDSDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P9</accession>
    <name>K9Z8P9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55102">
        <property type="protein sequence ID" value="AFZ55102"/>
        <property type="gene ID" value="Cyan10605_3045"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3045"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147397_1_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="95" mass="10946" checksum="DC28A05547F1BE00" modified="2013-03-06" version="1">MNKAQNLFKNIPFLVEGEEFLELLKCRNIAIERIVSSEKPDNKIYKQLQDEWVILIRGEATLKINDNVINIKAGDYVFIQAQTPHQVLTTSNNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U3</accession>
    <name>K9Z8U3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221294.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3546"/>
    <dbReference type="EnsemblBacteria" id="AFZ55579">
        <property type="protein sequence ID" value="AFZ55579"/>
        <property type="gene ID" value="Cyan10605_3546"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3546"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096820_0_0_3"/>
    <dbReference type="OMA" id="PRNNIGF"/>
    <dbReference type="OrthoDB" id="1401325at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="122" mass="13527" checksum="3AB670B72729D93C" modified="2013-03-06" version="1">MTIVMISGSRSVSELPSPALDSLNKIMDLGFDVVVGDCSGVDKLIQEYLYNHNYQNVTVYHINNKPRNNIGFQTVKVKGRSYSAKDIAMSEIADYGLAIWDGKSKGTKANIERIKKTKVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W8</accession>
    <name>K9Z8W8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3114"/>
    <dbReference type="EnsemblBacteria" id="AFZ55167">
        <property type="protein sequence ID" value="AFZ55167"/>
        <property type="gene ID" value="Cyan10605_3114"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3114"/>
    <dbReference type="eggNOG" id="ENOG5033E5W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136080_0_0_3"/>
    <dbReference type="OMA" id="EQSASHY"/>
    <dbReference type="OrthoDB" id="2027298at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="166" mass="19234" checksum="19970514CECFF6F1" modified="2013-03-06" version="1">MIALFLMPVLVFTWIFSVLKKERDLKKVLPKEIRVSKIISTYEKIGLGEGCGITIYKISPHTIGQINKQGLDFFKNLKVARGSELLEKQSPYYFYQDWRKTPIQENKNNKNFWFGLSCVNQKDLNKSLFEKIIQEANEANSYYTGHKEGQLVVIPSMRIVIFAYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z919</accession>
    <name>K9Z919_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3043"/>
    <dbReference type="EnsemblBacteria" id="AFZ55100">
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        <property type="gene ID" value="Cyan10605_3043"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3043"/>
    <dbReference type="eggNOG" id="ENOG5032U7I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1863173_0_0_3"/>
    <dbReference type="OMA" id="QIVPLEC"/>
    <dbReference type="OrthoDB" id="1951606at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="145" mass="16164" checksum="8FEB6796A84FD4A2" modified="2013-03-06" version="1">MSDNVNNQQKNQESSPDKNVFAPSETVETKESGNLFNQIKSFIFSWQLKVIIAAIALISSLWVIFFWKHIIALQSLKGWANHAQAEAIDCMMQDSNDDKYISCSAKLDNQIVPLECGTSLFNMGCRVNYGSASPSVKLQEKSIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z928</accession>
    <name>K9Z928_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3053"/>
    <dbReference type="EnsemblBacteria" id="AFZ55110">
        <property type="protein sequence ID" value="AFZ55110"/>
        <property type="gene ID" value="Cyan10605_3053"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3053"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3253"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_2_0_3"/>
    <dbReference type="OMA" id="NPKLNNC"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017835">
        <property type="entry name" value="Hopen-assoc_HpnI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03472">
        <property type="entry name" value="HpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="42380" checksum="CDD2F4B03DB0BCB3" modified="2013-03-06" version="1">MGAIAFYVYSIYGVKSFFEEEIDINESFSPGISILKPLCGLEDNLRENLTSFIQQNYPQYQIIFCVRDVNDPVIILVQELIASFPEKDLQLIVCDRIFGYNYKASNLVNGLPHCDYDFILIADSDIEVKADYLKTIIQPFQEEKIAVVTCLYESIGNHLVSILESLNMSGNFIPRVITAKKLEGVKFAFGSTIVIRKKVLEEIGNFDQLINNIADDFLLGNLPTKLGYQVKLVNYIVTHHVGKETFINYLTRQIRWLKCIRVQRFWGYIGMIFTQGIATSTIFLCISNFKFFAFLLLIITYFLRLNLAYQVGIKYLKNSTCYQYLGLTILVDFINLYIWIKALFGNQIKWRDNEFIVNKDGELSKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9E4</accession>
    <name>K9Z9E4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220732.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2951"/>
    <dbReference type="EnsemblBacteria" id="AFZ55013">
        <property type="protein sequence ID" value="AFZ55013"/>
        <property type="gene ID" value="Cyan10605_2951"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2951"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3140"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007027_0_1_3"/>
    <dbReference type="OMA" id="YTNDLQN"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="589"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="645"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="919" mass="101639" checksum="5A433539BE99CA0E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA32</accession>
    <name>K9ZA32_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220926.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3157"/>
    <dbReference type="EnsemblBacteria" id="AFZ55208">
        <property type="protein sequence ID" value="AFZ55208"/>
        <property type="gene ID" value="Cyan10605_3157"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3157"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_3"/>
    <dbReference type="OMA" id="DSHAVYW"/>
    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="128" mass="14675" checksum="13BE2F22DC3540E5" modified="2013-03-06" version="1">MNILLDTHCWLWWLVEPEKLSQTAMATIQNNQNKLYLSVASIWEIGIKYKLGKLDLPISPEILIPQQMQIDKISSLSISVAHALNASILPSYHKDPFDRMLIAQSQLESMTIISNDSMFNSYNVQVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA38</accession>
    <name>K9ZA38_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase CbiC/CobH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220936.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3167"/>
    <dbReference type="EnsemblBacteria" id="AFZ55218">
        <property type="protein sequence ID" value="AFZ55218"/>
        <property type="gene ID" value="Cyan10605_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3167"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3375"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_3"/>
    <dbReference type="OMA" id="DLAWQAY"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="213" mass="23680" checksum="B281F4712D6F2FD8" modified="2013-03-06" version="1">MEWNLLTVQNFSIIDREIDKSVFSPAEYEIVKRVVFSTGDLEYASVINFANNPLSNGFAALETRVPIMVDTPVIQAGVLPFLQQTFMNPVYCLEDFALPASVTATKSKIWQKLSKNYPSAIYIIGENPVSLFSLLDLIESVQVKPSLIIATPSGFTRKEIINKMLQKSGVSHIRFDSYKGGVTVAIAIFQGLIELGWLAKNSTMPMKNPKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA39</accession>
    <name>K9ZA39_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221178.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3418"/>
    <dbReference type="EnsemblBacteria" id="AFZ55460">
        <property type="protein sequence ID" value="AFZ55460"/>
        <property type="gene ID" value="Cyan10605_3418"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3418"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3642"/>
    <dbReference type="eggNOG" id="COG5450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179376_3_0_3"/>
    <dbReference type="OMA" id="KLKWEGD"/>
    <dbReference type="OrthoDB" id="2064132at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="6839" checksum="BB23FE282FC19624" modified="2013-03-06" version="1">MKKQKLINEAMKITGLKTEAEVIELSLKTLINLKKQEEIKHFKGKLKWEGNLEEMRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA57</accession>
    <name>K9ZA57_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Group 1 truncated hemoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="3">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the truncated hemoglobin family. Group I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220961.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9ZA57"/>
    <dbReference type="STRING" id="755178.Cyan10605_3194"/>
    <dbReference type="EnsemblBacteria" id="AFZ55243">
        <property type="protein sequence ID" value="AFZ55243"/>
        <property type="gene ID" value="Cyan10605_3194"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3194"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103526_2_1_3"/>
    <dbReference type="OMA" id="HQKAFLT"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016339">
        <property type="entry name" value="Hemoglobin_trunc_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002030">
        <property type="entry name" value="Globin_Protozoa/Cyanobacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002030-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="13995" checksum="824AC940F6F3B38F" modified="2013-03-06" version="1">MSSLYEKLGGKEAVDIAVDKFYDKVLKDDRVNYFFANTDMKKQKAHQKAFMTYAFGGPDTFSGRDMRESHKHLVDNMGLTDVHFDAIAENLINTLKELGIEQNLIDEVGAIVGAVSHRNDVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAC6</accession>
    <name>K9ZAC6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Cmr4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221262.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3512"/>
    <dbReference type="EnsemblBacteria" id="AFZ55545">
        <property type="protein sequence ID" value="AFZ55545"/>
        <property type="gene ID" value="Cyan10605_3512"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3512"/>
    <dbReference type="eggNOG" id="COG1336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047795_0_0_3"/>
    <dbReference type="OMA" id="LMEHSLW"/>
    <dbReference type="OrthoDB" id="972874at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="299" mass="33123" checksum="5C3C1003203CA339" modified="2013-03-06" version="1">MSDFRVGYLYSLSPVHCGGEGDLGNILEIAREVHTNFPYIPGSTLRGNIRDELESIDETIAEKLFGRKLDDNGQMGVHQVWFGDARILWIPMRTMSHNNQDVFTWVSCHSLIRDHALIAHLPPVSLPNCAVGTSGGTYHVADAQINVTPISTLSDAQKGAITLSGDWSPSLGDSVKTAWENSHLILPDADFQILMEHSLWTQVRNKIQDSGDQAGSAEVFWTDVCIPRDTIFYYSWGYKLKTNHQITSEYHDKLMEIIQGLIQVGGQANVGRGWVQSWVANSASPVDDSQAKQTANINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAL7</accession>
    <name>K9ZAL7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3396"/>
    <dbReference type="EnsemblBacteria" id="AFZ55438">
        <property type="protein sequence ID" value="AFZ55438"/>
        <property type="gene ID" value="Cyan10605_3396"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3396"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042265_0_0_3"/>
    <dbReference type="OMA" id="YLQEVCY"/>
    <dbReference type="OrthoDB" id="454779at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="492" mass="58651" checksum="71AC42D877F52689" modified="2013-03-06" version="1">MVKNHWKSTFMKMQKRTNLVMQFSSFLCLKEESSSLITYWKITPELEQNMRQLLDQQEILAEEDDLIAQEFLEWLRDNQDNLKKKHLIAYLQESCFFATKKVYQRFKNCWNIFTWQDYFQWANLLLASPTKLLAKYNQSLRYKLTTYARSKIESQLIDRAYQYMGWERASDWGLLRQLKSGTRKKCLQIIGGLKDSDLEKYLLVWECFNVVYSSKTIKKNQKLPPPSANHFLKITQEYNFIVKNKGANLPNINQEECNLIISNCIEFARQYCSPKILNSGEYTENLVDQVNVNVREEKELQKEEYNQVDTILTNAFYELDLTQKILFELWKGLQLTQTEIAEIMGVNYGEFVREQYQVTRQINSTRQELLEKLVREILADSQITITKQKFKELKNPLDQWLQEYCKEVLSQKITEIYQLLSDNEKSTIMNNFQEKNFTDSDTLNHDLNPLAKNLKTKLIEDYQLFFPETNHINLCFVHLVEDWFINNYPNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAQ4</accession>
    <name>K9ZAQ4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ordered locus">Cyan10605_3433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221191.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3433"/>
    <dbReference type="EnsemblBacteria" id="AFZ55473">
        <property type="protein sequence ID" value="AFZ55473"/>
        <property type="gene ID" value="Cyan10605_3433"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3433"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3658"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_3"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20651" checksum="5A8703079F013D7C" modified="2013-03-06" version="1">MTLIDEIQNLMLKSVEKTQQDLNTIRTGRANASLLDKIMVDYYGAETPLKSLANISTPDATTLMIQPFDKGSISLLEKAISMSDIGLTPNNDGQIIRLNIPPLTAERRQEFVKIASKYAEEGKVAIRNIRRDAIDKVRKQEKASEISEDESRDLQDEIQKVTDKYTAKIDDILKVKEKELTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ63</accession>
    <name>K9YZ63_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217921.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0028"/>
    <dbReference type="EnsemblBacteria" id="AFZ52189">
        <property type="protein sequence ID" value="AFZ52189"/>
        <property type="gene ID" value="Cyan10605_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0028"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.30"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_3"/>
    <dbReference type="OMA" id="VIMPDEA"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9377" checksum="74E40FB8C4DC024D" modified="2013-03-06" version="1">MSIYVGNLSYDISENDLQSVFADYGEVKRVYLPLDRETKRKRGFGFVEMSNDDEEIKAIETLDGAQWMGRQIKVNKAKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZB7</accession>
    <name>K9YZB7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218013.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0124"/>
    <dbReference type="EnsemblBacteria" id="AFZ52281">
        <property type="protein sequence ID" value="AFZ52281"/>
        <property type="gene ID" value="Cyan10605_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0124"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.126"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036032_1_0_3"/>
    <dbReference type="OMA" id="HFEVCYY"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="47617" checksum="AF1AFF418F4B2775" modified="2013-03-06" version="1">MKEQILAQKQYPYYTIRWCEKMADIPQSAWNAMALPLKTPFLEWEWLHNLETSGSVKPRAGWQSCHLTVWRDNNLVAGAPLYIKGHSYGEFVFDHQWADLAYRLGIQYYPKLLGMTPFTPAVGYRFLIAEGENELQITELMVNAIDHFCINNKLSGCNFLFVDPQWKELISQLGYSAWMHHSYIWSDQNFHNFEDFLKIFKSNQRKNIKRERKVVEKAGLILKTLVGDEIPHYLYPYIYRFYSSTCDKFYWGSKYLTKKFFEQLYPNYSHRLMLAVVHRENDDHHPVAMSFCVRKGENLYGRYWGCLEEYDSLHFETCYYKPIEWAIAHGVKMYDPGAGGSHKRRRGFPATPNYSLHRFYHPRMNTILNHYIDEINMATEEEIRAINEDLPFNKKEIKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZK0</accession>
    <name>K9YZK0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="9" type="ordered locus">Cyan10605_0222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218108.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0222"/>
    <dbReference type="EnsemblBacteria" id="AFZ52376">
        <property type="protein sequence ID" value="AFZ52376"/>
        <property type="gene ID" value="Cyan10605_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0222"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.231"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024913_1_1_3"/>
    <dbReference type="OMA" id="QTKAPGH"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="7"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ThiG" evidence="8">
        <location>
            <begin position="393"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="578"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="600"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="649" mass="70376" checksum="036C0D242BC27668" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B8</accession>
    <name>K9Z0B8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218372.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0499"/>
    <dbReference type="EnsemblBacteria" id="AFZ52641">
        <property type="protein sequence ID" value="AFZ52641"/>
        <property type="gene ID" value="Cyan10605_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0499"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.529"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_3"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="153"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="31126" checksum="998EAEFCD8E5EE7E" modified="2013-03-06" version="1">MVDSSSTNKQRIALVIQYVGTNFHGWQRQPHYRSVQAEIEDAIASIVGHKVTIYGAGRTDSGVHASAQVAHFEVCSPIPAQKWAKVLNSCLPDGILIRASSEVAPHWHACFTATYRRYRYTIYTGKIPNLFLQPFTWHYYYQPLNENLMAEALKPMLGHHDMSAFRRAGSKRSHSLLEVQEVSCVRYEQDLINIEIQASGFLYGMVRLLVGMLVEVGAGTKSLTQFQDIWMNCRREEVKYSAPAKGLCLLRVGYPEFPFPESVWFNAQPIFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0N3</accession>
    <name>K9Z0N3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218440.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0568"/>
    <dbReference type="EnsemblBacteria" id="AFZ52709">
        <property type="protein sequence ID" value="AFZ52709"/>
        <property type="gene ID" value="Cyan10605_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0568"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737158_0_0_3"/>
    <dbReference type="OMA" id="NIKLAPR"/>
    <dbReference type="OrthoDB" id="1888699at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="42706" checksum="8ABEADBC63AF3ED6" modified="2013-03-06" version="1">MTDNSEKNIYSVIELKKSLKRTMIQLQKAIDILNQNSPDDLPNLTVVENLVKSSNALVDYLQLKNSSGEADINTIQSQEEKTETSEPKKVRTSNKKQKSFVKINQNFLLVLVLIISISFNIIALTNNSIFPKKNVSVASNVKDEEIISQTDNDENINIGDNIFLEPQIEEKVEQKNDETEEQEAYQIGENIFQEEENNQELDTPVSEKNDNNNEQNNNNPSEPEIISSEDETDLIKENQIDTPKSSNLNSTESQETSEPKQQIEENDQEDEGISLLTLNPEQYIIKNIENQIENITQKYGENLIVRVKANFSNNSLIITVGEKWYELSSNKQNNFAEEVFKQVKSLDFYKFKLENTEGKILARNAVVGEGIILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R1</accession>
    <name>K9Z0R1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="4" type="synonym">rps18</name>
        <name evidence="6" type="ordered locus">Cyan10605_0155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218044.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0155"/>
    <dbReference type="EnsemblBacteria" id="AFZ52312">
        <property type="protein sequence ID" value="AFZ52312"/>
        <property type="gene ID" value="Cyan10605_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0155"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.161"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_3_3"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="71" mass="8349" checksum="C096901242E0F16B" modified="2013-03-06" version="1">MAYFRKRLSPIPLNQKIDYKDLELLHKFVTERGKMLPRRITGLTARQQRDLTNAVKRARQLALLPFLNVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0R2</accession>
    <name>K9Z0R2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulose bisphosphate carboxylase small subunit</fullName>
            <shortName evidence="3">RuBisCO small subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbbS</name>
        <name evidence="3" type="synonym">rbcS</name>
        <name evidence="5" type="ordered locus">Cyan10605_0642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexadecamer of 8 large and 8 small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuBisCO small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218512.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0642"/>
    <dbReference type="EnsemblBacteria" id="AFZ52781">
        <property type="protein sequence ID" value="AFZ52781"/>
        <property type="gene ID" value="Cyan10605_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0642"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.678"/>
    <dbReference type="eggNOG" id="COG4451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098114_2_0_3"/>
    <dbReference type="OMA" id="KQCQVLS"/>
    <dbReference type="OrthoDB" id="1708389at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03527">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00859">
        <property type="entry name" value="RuBisCO_S_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024681">
        <property type="entry name" value="RuBisCO_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262">
        <property type="entry name" value="PTHR31262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00152">
        <property type="entry name" value="RUBISCOSMALL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="SSF55239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="2 3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="3" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_small" evidence="4">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="13158" checksum="42B8D9A11A699060" modified="2013-03-06" version="1">MQTLPKERRYETLSYLPPLTDQQIVKQVQYLLDQGFIPAVEFEKDPQPKDHHWTLWKLPLFNASSAQEVLNEVRECKAQYSDSYIRVIGFDNIKQCQTMSFIVYKPNSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X6</accession>
    <name>K9Z0X6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217932.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0039"/>
    <dbReference type="EnsemblBacteria" id="AFZ52200">
        <property type="protein sequence ID" value="AFZ52200"/>
        <property type="gene ID" value="Cyan10605_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0039"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.41"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_0_2_3"/>
    <dbReference type="OMA" id="QFFHPLN"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="24128" checksum="D3D1D3E6E2C0B63C" modified="2013-03-06" version="1">MKILVVGATGQTGRRIVAELVKRKIPVMAMVRDKAKARDVLPACVDLIIADVLNPSSFASAMDECDIVICAAGATPSLDPTVFYWVDYEGTKNLINVAKKKQIEKFILVTSLCVSRFFHPLNLFGLVLFWKKQAENYLIDSGLTYTIIRPGGLRNEDNQYSLIVGEADTLFEGSISRQEVAKVCIESIFYPETNNRILEIIQAESAPAKDWQELLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Y9</accession>
    <name>K9Z0Y9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 12">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_0252</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 12"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218134.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0252"/>
    <dbReference type="EnsemblBacteria" id="AFZ52402">
        <property type="protein sequence ID" value="AFZ52402"/>
        <property type="gene ID" value="Cyan10605_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0252"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.261"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_3"/>
    <dbReference type="OMA" id="YMDIIWR"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="36332" checksum="0B5622D67089A88F" modified="2013-03-06" version="1" precursor="true">MFPINRPRRLRASVGLRRMVQETVLTPNDLIYPLFAVPGNAIAKEVKSMPGVYQLSVDKIVEEAKEVYDMGIPAIILFGIPEDKDNEATGAWHDCGIVQKATTAVKEAVPDLIVMNDTCLCEYTPHGHCGYLEVGDLVGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVKVIREALDENGFSHIPIMSYAAKYASAYYGPFRDAAESAPSYGDRRTYQMNPANSLEALKEIELDIAEGADMLMVKPALSYMDIIWRVKEATNLPVAAYNVSGEYSMVKAAALNGWIDEKKVTIETLMSFKRAGADLILTYHAKDAVRWLNEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Z6</accession>
    <name>K9Z0Z6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="5" type="synonym">rps6</name>
        <name evidence="7" type="ordered locus">Cyan10605_0064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217957.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0064"/>
    <dbReference type="EnsemblBacteria" id="AFZ52225">
        <property type="protein sequence ID" value="AFZ52225"/>
        <property type="gene ID" value="Cyan10605_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0064"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.66"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_4_2_3"/>
    <dbReference type="OMA" id="ETIFLVK"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="149" mass="17001" checksum="850C47EE3F6783C8" modified="2013-03-06" version="1">MTNTYEMMFVLRPDLTQEQVNGQMRKYRDFLKENGAEKVSLEVWGKRRLAYPIQKFQEGIYILTYYTGDGSQVASIERDMRLGEEVLRYLTIKLDSDFDFEEKDIPSAPSTASESPIELPTPAAADSSPTEESSEEEVEVEETETPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z104</accession>
    <name>K9Z104_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0748"/>
    <dbReference type="EnsemblBacteria" id="AFZ52881">
        <property type="protein sequence ID" value="AFZ52881"/>
        <property type="gene ID" value="Cyan10605_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0748"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.785"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_3"/>
    <dbReference type="OMA" id="QQMINAN"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017848">
        <property type="entry name" value="RNA_pol_sigma_RpoD_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02997">
        <property type="entry name" value="Sig70-cyanoRpoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="399" mass="45753" checksum="6270309A2F4367A0" modified="2013-03-06" version="1">MTNFDVKPLKDRPSTSPTSSSSGHNSRATYSPPSTQNSPYINSRDLMRLYLRDIGRIPLLTKEEEITLAKEIKASQNLLAIRDKNRELPVLAKYLEIMTIFDSLVANHSEAVKIGKIAQQLNLTPKKVESIITEGKETWANLAQVKLSELETILANGIKAKQKMINANLRLVVSIAKKYQNRGLELLDLIQEGTLGLEKAVEKFDHTKGYHFSTYAYWWIRQGMTRAIATQARTIRLPIHITERLNQLKKVQRQLSQKLGRIATVDEIAKEMDMTSLDLRQFLNQIPRSISLEMKVGEDYNTELVELIETESATPEENLMRVSMQKDLRSMLSLLNEREQKILRLRYGFENGKIYSLSDTASIMNLSRERVRQIQAKAIQKLRQPNQKKSLRDYLEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z172</accession>
    <name>K9Z172_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0335"/>
    <dbReference type="EnsemblBacteria" id="AFZ52482">
        <property type="protein sequence ID" value="AFZ52482"/>
        <property type="gene ID" value="Cyan10605_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0335"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810667_0_0_3"/>
    <dbReference type="OrthoDB" id="355416at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="39344" checksum="228A4AF16E761209" modified="2013-03-06" version="1">MCQEKLKLIFFSFTYSIFYKLAFLLLLILIFYRVQIKFNVITKNACFISILPLFVTQFVITLSCYYKFGLSSLPRQLSFKSALIGLLLVIIALIIASNLSYKSKKFRFKSILNNSINLLITFSLTFILLINLQFKYLKQDLNNLSNIVASNTQNWQENLNSDQPIAIYTTILTHYVGRTYLDDGFYPSCDKEEGFNVFAERYANYFNKNKLYVIPFNSESPNFNLNILQKKANKINFICSHSSDLGNVDSINQSEIKNSVFELVENQEIVLTGWAINPDKSKGKKVLITMGDDNKIVKETQVNLPRPDVADYFNNPIYLNSGWLLSFIPTINASQDPVKFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D3</accession>
    <name>K9Z1D3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218705.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z1D3"/>
    <dbReference type="STRING" id="755178.Cyan10605_0842"/>
    <dbReference type="EnsemblBacteria" id="AFZ52974">
        <property type="protein sequence ID" value="AFZ52974"/>
        <property type="gene ID" value="Cyan10605_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0842"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.885"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_3"/>
    <dbReference type="OMA" id="LSTMDHC"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="593"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="801" mass="91104" checksum="452D59634A335402" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F7</accession>
    <name>K9Z1F7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photosystem I reaction center subunit IX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">psaJ</name>
        <name evidence="10" type="ordered locus">Cyan10605_0260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-40</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May help in the organization of the PsaE and PsaF subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cellular thylakoid membrane</location>
            <topology evidence="2 8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PsaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218142.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="8/J/j=2-40"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z1F7"/>
    <dbReference type="STRING" id="755178.Cyan10605_0260"/>
    <dbReference type="EnsemblBacteria" id="AFZ52410">
        <property type="protein sequence ID" value="AFZ52410"/>
        <property type="gene ID" value="Cyan10605_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0260"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.270"/>
    <dbReference type="eggNOG" id="ENOG5033A5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212133_1_1_3"/>
    <dbReference type="OrthoDB" id="2064773at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00522">
        <property type="entry name" value="PSI_PsaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002615">
        <property type="entry name" value="PSI_PsaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036062">
        <property type="entry name" value="PSI_PsaJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36082">
        <property type="entry name" value="PTHR36082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01701">
        <property type="entry name" value="PSI_PsaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81544">
        <property type="entry name" value="SSF81544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="42" mass="4671" checksum="DB8F4C14FC33CF09" modified="2013-03-06" version="1" precursor="true">MKGLTTFLSTAPVLITALLVFTAGLLIEFNRFYPDLLFHPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G0</accession>
    <name>K9Z1G0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218777.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0916"/>
    <dbReference type="EnsemblBacteria" id="AFZ53046">
        <property type="protein sequence ID" value="AFZ53046"/>
        <property type="gene ID" value="Cyan10605_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0916"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.963"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_8_1_3"/>
    <dbReference type="OMA" id="TGLCGTC"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10443" checksum="CE70113CCE7A95DF" modified="2013-03-06" version="1">MLCKISFTNNEFPPLELPAHQSLADHLTAQNSPILFGCRTGLCGTCLVEIIGNIPPPKEEEKEVLQILAPENPRVRLACQLDLTQDITIKTYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1J4</accession>
    <name>K9Z1J4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218182.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0302"/>
    <dbReference type="EnsemblBacteria" id="AFZ52450">
        <property type="protein sequence ID" value="AFZ52450"/>
        <property type="gene ID" value="Cyan10605_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0302"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270713_0_0_3"/>
    <dbReference type="OMA" id="LQGHHYE"/>
    <dbReference type="OrthoDB" id="56732at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="817"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1212" mass="141399" checksum="A720D66DBDEF0209" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K4</accession>
    <name>K9Z1K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218192.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0312"/>
    <dbReference type="EnsemblBacteria" id="AFZ52460">
        <property type="protein sequence ID" value="AFZ52460"/>
        <property type="gene ID" value="Cyan10605_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0312"/>
    <dbReference type="eggNOG" id="ENOG502ZU7W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776527_0_0_3"/>
    <dbReference type="OMA" id="RYWVLGD"/>
    <dbReference type="OrthoDB" id="1468927at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="18142" checksum="BC0E6F0EDCAE379F" modified="2013-03-06" version="1">MTHTFLLESGSWIIKGTWLDKNQQSNPFKGAIIINWEQSNWFSMQMKIVFPQNVPQSGSFQNRPEIIFEYKGLIPSNRSRYAYVLKRSDLEKIEGEGWISNDSIIQRYWVLGNTRRLNGFETFFCLDENTYHLTSGMMTGNNLLYTFEGILDRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P1</accession>
    <name>K9Z1P1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218810.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53079">
        <property type="protein sequence ID" value="AFZ53079"/>
        <property type="gene ID" value="Cyan10605_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0949"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056539_0_1_3"/>
    <dbReference type="OMA" id="LAMYVLV"/>
    <dbReference type="OrthoDB" id="1179665at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="34138" checksum="32C046F584D57D35" modified="2013-03-06" version="1" precursor="true">MTKLRQLIPILFVIILLSISVAAIASELKKYNINSVWQYLQNISQQRKMLALLVTGFGYALMTGYDILGFIHIKQKLSVLKIAFTAFVSYAVGNTVGFTAFSGTAIRYRYYGLWGVNKIKIGELIVFTHLTFWLGLLSISGIVSILDPLTLPSAIKLPFASIHPLGFIFLSLVLIYFIISVTIKHSVTIAGEEITFPKPIISLGTIIVAGLDWGLAALVLYLLLPPNLSMTYIGFFGIYIVALTAGLISTVPGGLGVFETVMLYLRPESISAPQMLGGLIAYRFVYYLLPLIFAVVLILLEAWKKRHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U1</accession>
    <name>K9Z1U1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="6" type="synonym">rps7</name>
        <name evidence="10" type="ordered locus">Cyan10605_0411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218286.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0411"/>
    <dbReference type="EnsemblBacteria" id="AFZ52555">
        <property type="protein sequence ID" value="AFZ52555"/>
        <property type="gene ID" value="Cyan10605_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0411"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.434"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_3"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17514" checksum="0773EA1C65AD59F1" modified="2013-03-06" version="1">MSRRSKAKTVEVPPDPVYNSRLVNMTVRRIMKDGKKSLAAKILYDALSIIGERTGAEPMETFEKAIKNLTPLVEVKARRVGGATYQVPMEVRPGRGTSLALRWLTQFARKRSGKSMSMKLANEIMDAANETGAAIKKREETHKMAEANKAFAHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1U7</accession>
    <name>K9Z1U7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218865.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1005"/>
    <dbReference type="EnsemblBacteria" id="AFZ53134">
        <property type="protein sequence ID" value="AFZ53134"/>
        <property type="gene ID" value="Cyan10605_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1005"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1062"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_5_3"/>
    <dbReference type="OMA" id="VKFLDYV"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="365" mass="41840" checksum="465F54947FC9097C" modified="2013-03-06" version="1">MEKPLLVNLSMLLAKPTGIANYVINILPYFDSLEYISLVAKQYYQENIYKNPYFVSEKYSPDYGSKGHFLRLLWTQLKVPNIYQQSGSNLLFSPVPEMPLFSKVKSVIMVHDLIPLRFPKKNSPLTPYFRYYIPQVCQQAEHIICNSKATADDIINFFGINADKITPIYLGYNPETFKVIDKIKPINKKPFFLYLGRHDPHKNVERIVSAFAQFKHHQKYELWLAGPTDSRYTPLLKQQAKELNIAHLVKFLDYVKREDLPIILNQAQALVFPTLWEGFGFPVLEAIASGTPVITSNISSLPEVVGDAGILVNPLEVKEIASAMNLMAEDDKLRQQLRELGLKQAQKFSWQKTAQATIELLFNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1W9</accession>
    <name>K9Z1W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antidote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218907.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1050"/>
    <dbReference type="EnsemblBacteria" id="AFZ53176">
        <property type="protein sequence ID" value="AFZ53176"/>
        <property type="gene ID" value="Cyan10605_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1050"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1111"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179961_1_0_3"/>
    <dbReference type="OMA" id="KRYHNAL"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013432">
        <property type="entry name" value="Doc_partner"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02609">
        <property type="entry name" value="doc_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8529" checksum="E60E27FAF35D61CE" modified="2013-03-06" version="1">MFRLKVTTVGNSTGVILPKEVLAKMHVEKGDNLYLTPTPNGFEITPYNPEFEQEMETAREIMKQYRNALRELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2A7</accession>
    <name>K9Z2A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218598.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0733"/>
    <dbReference type="EnsemblBacteria" id="AFZ52867">
        <property type="protein sequence ID" value="AFZ52867"/>
        <property type="gene ID" value="Cyan10605_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0733"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.769"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068871_0_0_3"/>
    <dbReference type="OMA" id="SQFKAGF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="29349" checksum="1D1D211C7F873263" modified="2013-03-06" version="1">MSDIDNLKIELNKTKIAYQEALQNSRLKAGFMGRIAHEIRSPLSSLMGLHQLIINDLCESREEEREFIVEAYQYAKKLMAIIDQFVEVSKLETGRINPEIEIVNLQELLLDIHSLIYLEAANKNLKIKLEATENSQILTVKTDREKLINIIFLLLEIIIDYSEMGEILLSTSQNNEGVNININFPCKSFNMSENIDLLKSPIEELKQLNKLPQLSNGMKLMLVENVLNILGGYSTLKQIQETETTQWQLFLPTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B7</accession>
    <name>K9Z2B7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">Cyan10605_0744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218608.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0744"/>
    <dbReference type="EnsemblBacteria" id="AFZ52877">
        <property type="protein sequence ID" value="AFZ52877"/>
        <property type="gene ID" value="Cyan10605_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0744"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.781"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_1_3"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16541" checksum="7FAEFCCB80746596" modified="2013-03-06" version="1">MTKLNLQLENQYSEALEHLPTVDSKELALMIAEAADDRKADNIVLLNVEKLSYVADYFVIVTGFSQPQLRAISTSIEDKIEEKFQRLPVRVEGKTDGNWILHDYGDVIAHIFLPEAREFYNLEAFWGGAEKIIYNSEYQSQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C8</accession>
    <name>K9Z2C8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219028.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1178"/>
    <dbReference type="EnsemblBacteria" id="AFZ53299">
        <property type="protein sequence ID" value="AFZ53299"/>
        <property type="gene ID" value="Cyan10605_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1178"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1244"/>
    <dbReference type="eggNOG" id="ENOG5033F7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199748_0_0_3"/>
    <dbReference type="OMA" id="MLTLQIT"/>
    <dbReference type="OrthoDB" id="2070402at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8504" checksum="2929A621F573B18E" modified="2013-03-06" version="1">MVTLTITKNQILNLIDQLSLSEQEEILKYLMQKTNLDPDDTPNEIVIEGIKQGLNEAFTGQTIPLSQMWEGIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H6</accession>
    <name>K9Z2H6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sbcD</name>
        <name evidence="8" type="ordered locus">Cyan10605_0626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218496.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0626"/>
    <dbReference type="EnsemblBacteria" id="AFZ52765">
        <property type="protein sequence ID" value="AFZ52765"/>
        <property type="gene ID" value="Cyan10605_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0626"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.660"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038682_0_0_3"/>
    <dbReference type="OMA" id="GNHDQHS"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="411" mass="45815" checksum="B48A6E90BC7F5B51" modified="2013-03-06" version="1">MKILHLSDIHLGSSFSHGKINPETGLNTRLEDFTRSLSACIDDAIASEVDLVLFGGDAFPDSTPAPYIQAAFANQFRRLVDKNIPTVLLIGNHDQHSQGMGGASLSIYDRLGVPNFIVGEKLKTHTINTKSGDIQVITLPWLTPNVLFTSLETEGESMDKIYGLLIQKIELILEAEVRKLNPNIPTILLGHLMAERATLGAERYLAVGKGFQVPLSLLIRPEFDYVALGHVHKHQNLNPKNNPPVVYPGSIERVDFSEEKEEKGYVLIDIIEKEVNWQFCPLPTRPFVTIEVDVTASDNPLQTIINAIAHKSKKIESAVVRLIYRLRSEQIELINIKEIHQALSMAHTYTIKAESVSELARARLPELGIGRSLDPLEALSTYLNNREDLRDLVPEMLEAANQLLNNVTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K2</accession>
    <name>K9Z2K2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Late competence development protein ComFB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219108.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1263"/>
    <dbReference type="EnsemblBacteria" id="AFZ53379">
        <property type="protein sequence ID" value="AFZ53379"/>
        <property type="gene ID" value="Cyan10605_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1263"/>
    <dbReference type="eggNOG" id="ENOG502Z8SJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467558_0_0_3"/>
    <dbReference type="OMA" id="GRICDNA"/>
    <dbReference type="OrthoDB" id="1627466at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019657">
        <property type="entry name" value="ComFB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10719">
        <property type="entry name" value="ComFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="19791" checksum="AD5EBABE25BDA73E" modified="2013-03-06" version="1">MDIEKIVEQALETGYLTPSMEAEVGRLCDASGELSAEEYKALDKLMGALLTGEITATPKKQFINVMEELVVSEVISRVAEIETTSDTLLDVGDISAYALNRLPPLYATTEEGAEFQRKKAKEELHGLILEQVEQAIALYLDRPSFYPERQAINKTGVTGGVFEQVSKLLQSQASLYEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2L9</accession>
    <name>K9Z2L9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type III effector Hrp-dependent outer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218546.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0677"/>
    <dbReference type="EnsemblBacteria" id="AFZ52815">
        <property type="protein sequence ID" value="AFZ52815"/>
        <property type="gene ID" value="Cyan10605_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0677"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.713"/>
    <dbReference type="eggNOG" id="COG3395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044742_0_0_3"/>
    <dbReference type="OMA" id="VHETEFA"/>
    <dbReference type="OrthoDB" id="771666at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
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        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
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        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="265"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="442" mass="49169" checksum="C30C9CE1A1CA6C9E" modified="2013-03-06" version="1">MTQAPKIIVLDDDPTGSQTVHSCLLLMKWDIDTLRDGLRDSCPIFFILTNTRALTPETAQQVTQEVCRNLKSAIALEGIQEYLVVSRSDSTLRGHYPLETDVIAQELGEFDAHFLIPAFFEGGRITRDSIHYLMIDGKPTPVHETEFAQDSVFGYSYSYLPDYVEEKTKGKIKAHQVQRFLLDDIRNDTKNRLRELKDNQCVVVDGEKQSDLDQLSTDILTVAQEGKKFLFRSAASILTSLAQLGEQPVKAEAMAEYKPNTNNGVIIVGSHVKKTTQQLKQLLSQPDIFGVEIDVNLLKDDLKNRESLIKSALDKVETILKENKTPVVYTSRQELSFPDIDTRLEFGKQVSAVLMDIVRGLPKDIGFLISKGGITSNDVLSDGLALKEARLLGQILAGCSVIITPDNHHLFPSLPVVLFPGNVGDENGLVTVYQRLNNNKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z328</accession>
    <name>K9Z328_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plasma-membrane proton-efflux P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0858"/>
    <dbReference type="EnsemblBacteria" id="AFZ52990">
        <property type="protein sequence ID" value="AFZ52990"/>
        <property type="gene ID" value="Cyan10605_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0858"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.902"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_3"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="842" mass="91505" checksum="FB67D88EAEB29025" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z382</accession>
    <name>K9Z382_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219393.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1557"/>
    <dbReference type="EnsemblBacteria" id="AFZ53666">
        <property type="protein sequence ID" value="AFZ53666"/>
        <property type="gene ID" value="Cyan10605_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1557"/>
    <dbReference type="eggNOG" id="ENOG5031C9S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000659_0_0_3"/>
    <dbReference type="OMA" id="AACPLTC"/>
    <dbReference type="OrthoDB" id="1833150at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="13772" checksum="DAA1065FC5B68455" modified="2013-03-06" version="1" precursor="true">MHISNQNTWHDSYLLSMTKSFLVWNLTLTVCFLVVGFPLVVVLMTVGVLAAVVLQSVFPASALVLVSSGMLGVILSCILFSSIILTLKGVHPNEVKWLGWLQDNEKVTRRALYASCPLTCSITQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C9</accession>
    <name>K9Z3C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219386.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1550"/>
    <dbReference type="EnsemblBacteria" id="AFZ53659">
        <property type="protein sequence ID" value="AFZ53659"/>
        <property type="gene ID" value="Cyan10605_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1550"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1645"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_1_3"/>
    <dbReference type="OMA" id="QEDPTDA"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="351" mass="37817" checksum="5A4808DED76AAB01" modified="2013-03-06" version="1" precursor="true">MSISFRNIALVAITVLLILLLWQLRSLLVILMISVVLAATLAPIVDCGEKMRIPRWLGVILAYLSIILIITGGGLVIGPTVIAQIERLLQKLPGYLDIITNLTQSLIIRFGITEPQALNLIDQWLDLQALASWAVRSSQKVILSSLGLTRGIVGAIFNILLSIILSGYLLAGSKKLIKDFVSIFPSPWDAKLEAQFPPMSDRMGKYIQGRILVSLILGVAITIGLKFIGISEFALGLGVIAGFTNLIPFFGPVIGSIPALIVAIAQGGLTFWWVLLLFVIIQNVETYVLDPLLVGSSVEIEPLYQLLAVLGGVQVLGIIGALIVPPWVAGAGVVLENLYLKPKLTKENASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3E5</accession>
    <name>K9Z3E5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b6-f complex iron-sulfur subunit</fullName>
            <ecNumber evidence="13">7.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein</fullName>
            <shortName evidence="13">ISP</shortName>
            <shortName evidence="13">RISP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">petC</name>
        <name evidence="15" type="ordered locus">Cyan10605_0985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]</text>
            <dbReference type="Rhea" id="RHEA:22148"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="7.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rieske protein, while the 4 small subunits are PetG, PetL, PetM and PetN. The complex functions as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cellular thylakoid membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="13">The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The Rieske iron-sulfur protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.6" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218846.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0985"/>
    <dbReference type="EnsemblBacteria" id="AFZ53115">
        <property type="protein sequence ID" value="AFZ53115"/>
        <property type="gene ID" value="Cyan10605_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0985"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1040"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_8_0_3"/>
    <dbReference type="OMA" id="WGIVDNC"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045158">
        <property type="term" value="F:electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009496">
        <property type="term" value="F:plastoquinol--plastocyanin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01335">
        <property type="entry name" value="Cytb6_f_Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023960">
        <property type="entry name" value="Cyt_b6_f_Rieske"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ53115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="178" mass="19362" checksum="7060FDCF438D9300" modified="2013-03-06" version="1" precursor="true">MEQSFPYDESASMSRRNLLNFITGAAIAVTAGGVLYPVGKFFIPPSDVGEDGSILAKDVNGNLIPASQILAEPIGTRALVAGLAGEPTYLTIKDDGTLHPWGIVDNCTHLGCTFPWNGNENQFQCPCHGSRYDEEGRVVRGPAPLPLKLAHINVDGDYIRISPWTENDPRTGEKPWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3G9</accession>
    <name>K9Z3G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nickel-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218871.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1012"/>
    <dbReference type="EnsemblBacteria" id="AFZ53140">
        <property type="protein sequence ID" value="AFZ53140"/>
        <property type="gene ID" value="Cyan10605_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1012"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1070"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_3"/>
    <dbReference type="OMA" id="RVCVMQR"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="345"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="598" mass="67539" checksum="F3BD267D90B776F8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P4</accession>
    <name>K9Z3P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219096.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1249"/>
    <dbReference type="EnsemblBacteria" id="AFZ53367">
        <property type="protein sequence ID" value="AFZ53367"/>
        <property type="gene ID" value="Cyan10605_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1249"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1317"/>
    <dbReference type="eggNOG" id="ENOG50306UD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702265_0_0_3"/>
    <dbReference type="OMA" id="DDYCVFG"/>
    <dbReference type="OrthoDB" id="1848533at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17090" checksum="D8DD45B33D5E81FE" modified="2013-03-06" version="1">MTNQVITQGIATQDYCVFGLATYFLREEGETKEVKIIEPIPSAALEALFKGIPTSYEKAIALTIGEIIKEDKLIKPSLFPSESLFCEDFINRTFAATRTYQNKPSAKELINLGDCKTDLNYSTERKRMLNNTNIVSDDDNVKQHPNTHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R7</accession>
    <name>K9Z3R7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin (2Fe-2S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218759.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0898"/>
    <dbReference type="EnsemblBacteria" id="AFZ53028">
        <property type="protein sequence ID" value="AFZ53028"/>
        <property type="gene ID" value="Cyan10605_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0898"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.943"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_7_3_3"/>
    <dbReference type="OMA" id="DCHIRTI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="11379" checksum="F23A7298EB93E7A4" modified="2013-03-06" version="1">MSNTYTVKIHNAGQSYTIQVSEDQKILDVAQQQNIELPSSCNAGVCTTCAAKIITGKVEQGEGMGLSPELQGEGYALLCVSYPRSDLELETGKEDEVYDRQFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W8</accession>
    <name>K9Z3W8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="5" type="synonym">rpl34</name>
        <name evidence="7" type="ordered locus">Cyan10605_1143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218994.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1143"/>
    <dbReference type="EnsemblBacteria" id="AFZ53265">
        <property type="protein sequence ID" value="AFZ53265"/>
        <property type="gene ID" value="Cyan10605_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1143"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1210"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_1_3"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="45" mass="5362" checksum="94D95EBE36229E67" modified="2013-03-06" version="1">MSKYTLNGTRRKQKRTSGFRARMRTKNGRKVIQARRNKGRKRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z407</accession>
    <name>K9Z407_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alaninecarboxypeptidase/D-alanyl-D-al anine-endopeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219658.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1829"/>
    <dbReference type="MEROPS" id="S13.002"/>
    <dbReference type="EnsemblBacteria" id="AFZ53931">
        <property type="protein sequence ID" value="AFZ53931"/>
        <property type="gene ID" value="Cyan10605_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1829"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1941"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_3"/>
    <dbReference type="OMA" id="DGTMRKR"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="493" mass="55861" checksum="E38916BA915207C5" modified="2013-03-06" version="1" precursor="true">MIKKNIFYRVLLSILIGFYNIFFYSLSSKAEVKELSEYNQSQVCIQGLESAINSILNQSERSRENWGILIEKLNKNQTLYKLNENKYFIPASNVKLFTTASFLLNFGENFTIKTPIYIKGKEEFIDELIIIGKGDPTITKSDLEDIAKKLQQLNINHVKNLILVNSSPIKYPFNNSWEFSDLYFYYAVPINSFILEENTVTLSLTPSQVGKQILLKWSDKLAGKQWLITNEGVTVSEDEEYSINLNPMGLESRLRIEGNLPVNNHDDNWWLSIPNPEQYFQDSLIAILQNNGIQVEKTEIIDQKNIDLSDANLLLEINSPNSNNLIAEINQNSNNLYAEILLSYLATNQDTKFISQTKILENIGLLSNDYSLKDASGLSRQNLVTPKSLVTLLKLMDKTEYAKTFRNSLSLAGVNGTLKNRFQNEDIIDNNLWGKTGTLTGVSALSGYLRTKDDDVVFSIMVNNSSALSKELRDVIDKLLVIVAQSQHCANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z452</accession>
    <name>K9Z452_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219641.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1812"/>
    <dbReference type="EnsemblBacteria" id="AFZ53914">
        <property type="protein sequence ID" value="AFZ53914"/>
        <property type="gene ID" value="Cyan10605_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1812"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1923"/>
    <dbReference type="eggNOG" id="COG4956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050839_0_1_3"/>
    <dbReference type="OMA" id="TMPTDLL"/>
    <dbReference type="OrthoDB" id="940436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="289"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="39281" checksum="6AD881569F23C552" modified="2013-03-06" version="1">MIDIIIITIFVLAFGGVGFDIVELLPSEIQNQVSNIQALRWLVAGFASIIGLAIGLVAQTTYRRLEQKIRQTPIEVIITRAIGLAMGLLLANLLLAPIFLLPVPNNFSFIKPMIAILGSVMFTVLGVSLADTHGRTFLRLINPNSIESMLVAEGTLTPVATKILDTSCIIDGRIQQLLATGFIEGQILVPQFILAELQQLADATNDQKRVRGRRGLDILNQMQEEYPDKIVIHPEEYEEVTTVDAKLLHLAHDINAVLITNDFNLSKVATLQKITILNVNDLAQAVRPIYLPGDYIDLKILKHGKEPTQGIGYLDDGTMVVVEEANGHVGEELRVVVTSALQTSAGRMIFAKTYASAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z481</accession>
    <name>K9Z481_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hopanoid-associated sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1274"/>
    <dbReference type="EnsemblBacteria" id="AFZ53390">
        <property type="protein sequence ID" value="AFZ53390"/>
        <property type="gene ID" value="Cyan10605_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1274"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1345"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_3"/>
    <dbReference type="OMA" id="RYILGHQ"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017829">
        <property type="entry name" value="Hopanoid-assoc_sugar_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03466">
        <property type="entry name" value="HpnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="331" mass="36987" checksum="ED72906615EC0C1B" modified="2013-03-06" version="1">MKGRVFVTGATGFVGANLVRLLLQENYQVRALVRKNADLTNVKNLDIELVEGSLNDENLYNKMIGCDYLFHVAALYSLWSKDKELLYQTNVLGTKNVFHAARKANIKRTIYTSSVAAIGVRKDGVLADENYQSPVENLIGNYKKSKYYAEQEAHLAIKSGQDIVIVNPSTPIGAYDLKPTPTGEIIVRFLRGKMPGFVNTGLNFIDVQDVAKGHILALEKGKTGERYILGNQNLTLAEFLDKLARIANKSAPKVKFPVWFPLAVAYLDEYVLSKLGKNPSVAVEAVKMSSQYMFYNSQKAVKELGLPQTDIDKAIRDAVNWLWGRQGSWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z488</accession>
    <name>K9Z488_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="7" type="ordered locus">Cyan10605_1285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219129.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1285"/>
    <dbReference type="EnsemblBacteria" id="AFZ53400">
        <property type="protein sequence ID" value="AFZ53400"/>
        <property type="gene ID" value="Cyan10605_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1285"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1358"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_0_0_3"/>
    <dbReference type="OMA" id="MNQRHLW"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="6">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="303" mass="32978" checksum="70567942A02C381A" modified="2013-03-06" version="1" precursor="true">MDNKNCQRAVKTALSTIIGLSISGVLIAPTVRANGYQAQDGEVTSPIHNVLAKTSTAPVKEFLVTKLYQHQWDDQDAVTLHYNNIPLLTFLDTPDGKAINNATNFAKKLEQLSSNSAQASEINVAWNAKTEDYVITFANNELVRINEYVILPDSTEDLAHDALQATNRLRRLMGNATPLKEVKGQPKVVAKKQTQKATFAGVKNLRKAAQGIASWYGPGFHGRKTASGERFNQNALTAAHRSLPFGTRVKVTNLNNGRSVVVRINDRGPFTRGRIVDLSAGAARVIGLKSSGVAPVRIQILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F1</accession>
    <name>K9Z4F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219344.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53617">
        <property type="protein sequence ID" value="AFZ53617"/>
        <property type="gene ID" value="Cyan10605_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1507"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1599"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_3"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="28729" checksum="2A605CCFE04DCAD8" modified="2013-03-06" version="1">MITLLTDFGLQDIYVGVMKGIIKTINPDIDIIDLTHNIPPQNIIAASFALASAVDFFPDDTIHLAIVDPTVGSDRKIVAIAFEKGYIICPNNGIITGVLNKYQPQQVYELTNSNYWLNHNPSNTFHGRDIFAPMTAYLSKGIGLETLGHNLNQEDLVILDDINPIIKEKEIIGSIQYVDIYGNLITNIPSKMLENKSWYVQEGDNKIFPQSTYSNIKKKELLTLIGSHGYVEIAINQGNAKMILNKEYGDFITVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4M7</accession>
    <name>K9Z4M7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219861.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2047"/>
    <dbReference type="EnsemblBacteria" id="AFZ54136">
        <property type="protein sequence ID" value="AFZ54136"/>
        <property type="gene ID" value="Cyan10605_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2047"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2175"/>
    <dbReference type="eggNOG" id="COG5469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125446_2_0_3"/>
    <dbReference type="OMA" id="VECLWAC"/>
    <dbReference type="OrthoDB" id="1599787at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012863">
        <property type="entry name" value="DUF1636"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07845">
        <property type="entry name" value="DUF1636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11806" checksum="611CA75FF4198703" modified="2013-03-06" version="1">MAKHTLFVCKSCHRASQERPENPPFDDDIFLDKLNALCSEQFLDDEIEIRSIGCLWACDRGCVVSVGSVDKPTYLFVNLTPEESSLPLMEFLQLYLHSKKGNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R4</accession>
    <name>K9Z4R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219304.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1464"/>
    <dbReference type="EnsemblBacteria" id="AFZ53575">
        <property type="protein sequence ID" value="AFZ53575"/>
        <property type="gene ID" value="Cyan10605_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1464"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1552"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561170_0_0_3"/>
    <dbReference type="OMA" id="YVEWLGT"/>
    <dbReference type="OrthoDB" id="189605at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="54590" checksum="89E34AA6450D1EA4" modified="2013-03-06" version="1">MPTQTTFMPPICGSEARILSIVNHQDPIFLPHSNINPHQIKSAFACALHMHQPTIPAGHDGSLICNLQYMFEHQGEGDNHNAGTFAWCYSRMGDFIPELVGNGCSPRIMLDYSGNLLWGFQQMNRNDIIDNLKKITCDPHYNRYVEWLGTMWSHAVAPSTPIPDLKLQILAWQHHFASIFGDDALRRVKGFSPPEMHLPNHPDTAYEYIKALKDCGYRWLLVQEHSVERPEGGGLYHDDKYLPNRLVAKNSRGESVSIVALIKTQGSDTKLVAQMQPFYEAKGRGRQNIGDISVPSCVSQIADGENGGVMMNEFPGGYHPVWYQIKDSGEGVVGLNGTEYIELVESLGVKEEDFPVCQPVGQHKIWNAIGDDISPESVQNAIAHLQENDHQFHMDGASWTNDLSWVKGYENVLEPMNKLSAMFHQKFDRAVAEDPSVTQRHDYQEALLYTMLVETSCFRYWGQGTWTDYARELYRRGEEFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R9</accession>
    <name>K9Z4R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219132.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1288"/>
    <dbReference type="EnsemblBacteria" id="AFZ53403">
        <property type="protein sequence ID" value="AFZ53403"/>
        <property type="gene ID" value="Cyan10605_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1288"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_3_0_3"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="318" mass="35296" checksum="87AD2A7382960199" modified="2013-03-06" version="1" precursor="true">MLKKISRFLGLIFFVSIISIFIINKATVAHEKPLVDNGQIVSQNSEAINVRIIPLKDNIYMLTGEGGNIGLSVGDDGVLMIDSQFAYLSDKIKDEIKLINRRPVNYLINTHYHFDHVGGNENFANDGAVIIAHDNTFKQMQKDHSYPVLGMDVKASPASALPKITFNDVSNFHVNGNHIKAFAVPPAHTNSDIVIHFAKENIIHTGDLFFNGFYPFIDTEAGGSIDGMISAIDQILALSNEQTIIIPGHGERGDRASLIKFQEMLKTVNERVKERIAQNMTLDDIISEKPLADLDQEWGDGFLTSDQFLTIAYQGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W6</accession>
    <name>K9Z4W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219352.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1515"/>
    <dbReference type="EnsemblBacteria" id="AFZ53625">
        <property type="protein sequence ID" value="AFZ53625"/>
        <property type="gene ID" value="Cyan10605_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1515"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517526_0_0_3"/>
    <dbReference type="OrthoDB" id="906801at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="460"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="526" mass="61138" checksum="CF617E7628E78422" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Y6</accession>
    <name>K9Z4Y6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2144"/>
    <dbReference type="EnsemblBacteria" id="AFZ54231">
        <property type="protein sequence ID" value="AFZ54231"/>
        <property type="gene ID" value="Cyan10605_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2144"/>
    <dbReference type="HOGENOM" id="CLU_150570_0_0_3"/>
    <dbReference type="OMA" id="HYPRHIP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025458">
        <property type="entry name" value="DUF4278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14105">
        <property type="entry name" value="DUF4278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="15041" checksum="3A935A7B05F1C3D0" modified="2013-03-06" version="1">MKYRGNVYKSENNFLEVKETDIVGGKYRGCQWNHKLPRHVTQLRPKLGLQYRGVSYCTNPTMSNSVDSNTNVAPINNKSRKVIVCEKIHSIHLENMRRNLERRIKAAQEENNETLLLMLKKESLELELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z504</accession>
    <name>K9Z504_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219976.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2165"/>
    <dbReference type="EnsemblBacteria" id="AFZ54251">
        <property type="protein sequence ID" value="AFZ54251"/>
        <property type="gene ID" value="Cyan10605_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2165"/>
    <dbReference type="eggNOG" id="ENOG5032S41">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172539_1_0_3"/>
    <dbReference type="OMA" id="MNSIGKR"/>
    <dbReference type="OrthoDB" id="1847473at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11238" checksum="7E760B96A61BFA16" modified="2013-03-06" version="1">MITIQEIEKYSENHPQEVLILRARDNQEEVEIMIFKGFSSNLTGSTAFDPDMPILSPDGEIISCDRILSPYNPNNPQYIEKNISPSELLKLLRENESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z505</accession>
    <name>K9Z505_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHPM bacteriocin system secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1719"/>
    <dbReference type="EnsemblBacteria" id="AFZ53822">
        <property type="protein sequence ID" value="AFZ53822"/>
        <property type="gene ID" value="Cyan10605_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1719"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1826"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028453_1_0_3"/>
    <dbReference type="OMA" id="IPLFRSW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022275">
        <property type="entry name" value="NHPM_bacteriocin_SS_HylD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03794">
        <property type="entry name" value="NHLM_micro_HlyD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="531" mass="59903" checksum="EE9FBFCD31E86E93" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z548</accession>
    <name>K9Z548_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="12" type="ordered locus">Cyan10605_1427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219267.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1427"/>
    <dbReference type="EnsemblBacteria" id="AFZ53538">
        <property type="protein sequence ID" value="AFZ53538"/>
        <property type="gene ID" value="Cyan10605_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1427"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1508"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_3"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
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    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
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    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
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    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="594"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="671" mass="75956" checksum="60F19577D3C0E653" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z556</accession>
    <name>K9Z556_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53680">
        <property type="protein sequence ID" value="AFZ53680"/>
        <property type="gene ID" value="Cyan10605_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1571"/>
    <dbReference type="HOGENOM" id="CLU_3381472_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="33" mass="3722" checksum="CB7D35BEF7AE6317" modified="2013-03-06" version="1">MQYCLNIFLLVGNNTHPTIFEAISTLIEVTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A3</accession>
    <name>K9Z5A3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phycobilisome degradation protein nblA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219317.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1477"/>
    <dbReference type="EnsemblBacteria" id="AFZ53588">
        <property type="protein sequence ID" value="AFZ53588"/>
        <property type="gene ID" value="Cyan10605_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1477"/>
    <dbReference type="eggNOG" id="ENOG503318Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185251_0_0_3"/>
    <dbReference type="OMA" id="YLLEMFR"/>
    <dbReference type="OrthoDB" id="2046146at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007574">
        <property type="entry name" value="NblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036904">
        <property type="entry name" value="NblA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04485">
        <property type="entry name" value="NblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109859">
        <property type="entry name" value="SSF109859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="55" mass="6462" checksum="D4E09B9E37E9A6F5" modified="2013-03-06" version="1">MDISASLTLEQQFKLEVLKDQVKALSKEQAQDYLIEVFRQMMVKDNMIKKIMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5A8</accession>
    <name>K9Z5A8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein PatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls heterocyst pattern formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nitrogen starvation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219654.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1825"/>
    <dbReference type="EnsemblBacteria" id="AFZ53927">
        <property type="protein sequence ID" value="AFZ53927"/>
        <property type="gene ID" value="Cyan10605_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1825"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1936"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031371_0_0_3"/>
    <dbReference type="OMA" id="QRFLITK"/>
    <dbReference type="OrthoDB" id="806256at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043158">
        <property type="term" value="P:heterocyst differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024186">
        <property type="entry name" value="Sig_transdc_resp-reg_PatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005897">
        <property type="entry name" value="RR_PatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0364">Heterocyst</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="270"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="47079" checksum="A505DF6F0791529C" modified="2013-03-06" version="1">MSSSGVFKKALLSLKGKKFTGRIDVKKADGKEWRVYFCLSRLVWADGGYHPYREWQRLLEKNCPDLDTHLLDIQKSKEFECWNYHLIVSLLQRFLITKEQALSLIKIKIKQALFDIYQAEFIEKLKYDVITIEDNFPEESGLKTSVSLLKIESILMELEVEWQHWQKFGLTHLIPHYAPVIKNPVLLQQHFKGKEKTYKKLVSLLNGKYPLTEIADKLNLTIFKITVWLKPYFEQDLITLIEIEDQPVAITLIGVTNQNYKITKTTYQQLIVCVDDSSQICEIMEHIITDAGYQYLSIREPLKALSQILKRKPDLIFLDLVMPIINGYELCSQIRRVSALKDVPIIILTSNDGMIDRLRSKLVGANGFLGKPIDQEKVLAKIKSCLSGKKTTSTLDSPEILQLTTDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5E7</accession>
    <name>K9Z5E7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219507.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1675"/>
    <dbReference type="EnsemblBacteria" id="AFZ53780">
        <property type="protein sequence ID" value="AFZ53780"/>
        <property type="gene ID" value="Cyan10605_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1675"/>
    <dbReference type="eggNOG" id="ENOG5032U0G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152016_1_0_3"/>
    <dbReference type="OMA" id="YYPLQPP"/>
    <dbReference type="OrthoDB" id="1950874at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="13874" checksum="B9627F72133DB2A7" modified="2013-03-06" version="1">MYYFPEPPLGLLFFGFFIGVTCGLAFESTLKQQVNIWMKRGQKNRTSDMSAMSRLTLPFFGVCLGICIFLAAGLEIFTYNRVISYLISGALTLLIGGLIWNQLQKLIIQLLEGGSKALDLDAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K6</accession>
    <name>K9Z5K6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220153.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2345"/>
    <dbReference type="EnsemblBacteria" id="AFZ54429">
        <property type="protein sequence ID" value="AFZ54429"/>
        <property type="gene ID" value="Cyan10605_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2345"/>
    <dbReference type="eggNOG" id="ENOG5032Y28">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089632_1_0_3"/>
    <dbReference type="OMA" id="AGVFYMA"/>
    <dbReference type="OrthoDB" id="1991946at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="24777" checksum="C616A4D36BF21652" modified="2013-03-06" version="1">MSQFYSTKTTYNRLFYNLLIFMVVTPFLQYFDRFNIWFPIIFFSTIILAINTLGFSKKFIYIFRGIAIFAYLSSIISHLQMLNHIDTIEIFSDVLSALFMILSIVAIALRILSETEINGDVIKGAICIYLMIGILWGIFYKILVNINANSFELSIFIDASPQYQLFYFSFTTLTTLGYGDISPLNSVGMMLSNIEALLGQLFPAIFISKLVSLSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L1</accession>
    <name>K9Z5L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220158.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2350"/>
    <dbReference type="EnsemblBacteria" id="AFZ54434">
        <property type="protein sequence ID" value="AFZ54434"/>
        <property type="gene ID" value="Cyan10605_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2350"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101369_0_0_3"/>
    <dbReference type="OMA" id="CASNTIL"/>
    <dbReference type="OrthoDB" id="1786010at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025478">
        <property type="entry name" value="COP23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14218">
        <property type="entry name" value="COP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="211" mass="23343" checksum="0D2446B0D1123C9C" modified="2013-03-06" version="1" precursor="true">MKNQFFIQFFIFGLLTIANGFFSQDSLAQTKNSYKCIQLNGKPTTIVDTARGRIQLIVWQNDFFRDSGWTPQKRCNEVTKRFQQFSDSGSLRYIATGTMNQQPVICVAEKKSSGFKCRGDGLLLTLQPKDNPSKVLTDLFNMSARTSTGGLSRGGVLDLDSFLATASTISSDNNDNLPTYNNNSPPPTIISNPETNQKPKDNPSCPPILCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5L9</accession>
    <name>K9Z5L9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219592.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1763"/>
    <dbReference type="EnsemblBacteria" id="AFZ53865">
        <property type="protein sequence ID" value="AFZ53865"/>
        <property type="gene ID" value="Cyan10605_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1763"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1871"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_2_0_3"/>
    <dbReference type="OMA" id="VYTEHRI"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21358" checksum="6044591780D3FA5F" modified="2013-03-06" version="1">MLTLPRKKFAIEEYHQIIASGVLKEDYLIELINGEIFEMSPVGFRHASCVNKLNQLLSLKLGNKAIISIQNPIKLNDNSEPQPDIVLLKPRHDFYANQHPTVEDIFLLIEVADSSIEYDRTFKIPIYAENKVQEVWLVDLNQNLLEVYQNPQTNYYQSIKKLSSQDSITLTQPETIAVKLDRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q8</accession>
    <name>K9Z5Q8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin (2Fe-2S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220249.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2445"/>
    <dbReference type="EnsemblBacteria" id="AFZ54526">
        <property type="protein sequence ID" value="AFZ54526"/>
        <property type="gene ID" value="Cyan10605_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2445"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2590"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_7_3_3"/>
    <dbReference type="OMA" id="MVIETHK"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10635" checksum="9ECFC09A36BB62CA" modified="2013-03-06" version="1">MATYNVTLITPDGEQTIEVPDDEYILDVAEEQGIDLPYSCRAGACSTCAGKLVEGTVDQSDQSFLDDDQIEAGYVLTCVAYPTSDCKIETHKEEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X9</accession>
    <name>K9Z5X9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219515.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1685"/>
    <dbReference type="EnsemblBacteria" id="AFZ53788">
        <property type="protein sequence ID" value="AFZ53788"/>
        <property type="gene ID" value="Cyan10605_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1685"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1788"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2478118_0_0_3"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="9580" checksum="46BC71AA3035B68F" modified="2013-03-06" version="1">MSKKNINSENQLLNNLPLSEYQRLLPHLQEVMLVSGSVLHEPYDAINYAYFPVSAMISLVSIMEDGSTTKIGLIGNEGMIGVPIFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z622</accession>
    <name>K9Z622_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="ordered locus">Cyan10605_1929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219750.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1929"/>
    <dbReference type="MEROPS" id="M41.017"/>
    <dbReference type="EnsemblBacteria" id="AFZ54025">
        <property type="protein sequence ID" value="AFZ54025"/>
        <property type="gene ID" value="Cyan10605_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1929"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2050"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_3"/>
    <dbReference type="OMA" id="QVMQFGQ"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="626" mass="68337" checksum="36FA95991E8973B7" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z653</accession>
    <name>K9Z653_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1960"/>
    <dbReference type="EnsemblBacteria" id="AFZ54055">
        <property type="protein sequence ID" value="AFZ54055"/>
        <property type="gene ID" value="Cyan10605_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1960"/>
    <dbReference type="HOGENOM" id="CLU_3006623_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="56" mass="6767" checksum="0B1406EFF35270EC" modified="2013-03-06" version="1">MTEKITDLEKQENSDKTDKKRKRKQRHKFNFFGLFIDILCEIVTSIFSFFNQFFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C6</accession>
    <name>K9Z6C6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase subunit MoaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220022.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2211"/>
    <dbReference type="EnsemblBacteria" id="AFZ54297">
        <property type="protein sequence ID" value="AFZ54297"/>
        <property type="gene ID" value="Cyan10605_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2211"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2350"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_3"/>
    <dbReference type="OMA" id="CPGIKAR"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="9810" checksum="59F2406C620993CD" modified="2013-03-06" version="1">MSVKVLIPTPLQKFTKDQATIECSASNIQELIDALEANCPGIKARLCDEAGVPRRFLNFYVNSEDIRFLDNTATPLSDGDEVSIVPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E1</accession>
    <name>K9Z6E1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ordered locus">Cyan10605_2226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220037.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2226"/>
    <dbReference type="EnsemblBacteria" id="AFZ54312">
        <property type="protein sequence ID" value="AFZ54312"/>
        <property type="gene ID" value="Cyan10605_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2226"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2366"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_1_3"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="376" mass="40422" checksum="B204AB8ED2D03ED9" modified="2013-03-06" version="1">MAGDYYEILGVSRNASKDEIKSAYRKMARKYHPDVNQDPGAEERFKEISRAYEVLSDPETKARYDRFGEAGVGGAGSGGVGFDPTDMGGFADIFETFFGGGFGGGTSTQTRRRGPTRGDDLRLDLRLKFREAVFGGEKEIKIPHLETCSSCNGSGAKKGSSAKTCGTCGGTGQVRRATRTPFGSFAQVSTCPTCNGEGQIIEEKCDSCGGQGRKQVNKKLKITIPAGVDNGTRLRVSSEGDAGTRGGPAGDLYVYLTVESDSHFRREGINILSEISISYLQAILGCKIKVPTIDGDFEVQIPAGLQPNTVLTLEDKGVPKLGNSVSRGDHLLTVKVDIPTKISGEERDLLEKLAQIKGEHTSKKGFEGFLESIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6E2</accession>
    <name>K9Z6E2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219870.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2056"/>
    <dbReference type="EnsemblBacteria" id="AFZ54145">
        <property type="protein sequence ID" value="AFZ54145"/>
        <property type="gene ID" value="Cyan10605_2056"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2056"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2154170_0_0_3"/>
    <dbReference type="OMA" id="WCQENGW"/>
    <dbReference type="OrthoDB" id="1785936at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="11945" checksum="0DF43768C891A3AE" modified="2013-03-06" version="1">MKHFCDDWIQEWCDHNGWTDWFLECRDYWAFPPHSVMPLPIPKETLMEIKAEKGFSPEEKIWLSISVAISIAGGVFSYFLNCPMPVVLAFAFTAIIIANFELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G8</accession>
    <name>K9Z6G8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photosystem II protein Y</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psbY</name>
        <name evidence="8" type="ordered locus">Cyan10605_2640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cellular thylakoid membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PsbY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220437.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2640"/>
    <dbReference type="EnsemblBacteria" id="AFZ54714">
        <property type="protein sequence ID" value="AFZ54714"/>
        <property type="gene ID" value="Cyan10605_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2640"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2805"/>
    <dbReference type="HOGENOM" id="CLU_218393_1_0_3"/>
    <dbReference type="OrthoDB" id="2091521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00717">
        <property type="entry name" value="PSII_PsbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009388">
        <property type="entry name" value="PSII_PsbY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06298">
        <property type="entry name" value="PsbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="40" mass="4338" checksum="D594CF7B64EC570A" modified="2013-03-06" version="1" precursor="true">MDWRVLIVLLPLGVAAGWALFNIGAAAIAQFQKVLNKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H1</accession>
    <name>K9Z6H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2257"/>
    <dbReference type="EnsemblBacteria" id="AFZ54342">
        <property type="protein sequence ID" value="AFZ54342"/>
        <property type="gene ID" value="Cyan10605_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2257"/>
    <dbReference type="eggNOG" id="ENOG5032RRG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179865_0_0_3"/>
    <dbReference type="OMA" id="HFIITAY"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12655" checksum="995A4E198538A083" modified="2013-03-06" version="1">MNNSEKDSILFEIITPLGFVVRTTVGYWNIISTVKHPIMQNRLEDVMQTLMSPDEIRVSKNDEKVFLFYRADGNKRWVCAVSKKLEIDGFLITAYRTSAIKEGILLWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Q9</accession>
    <name>K9Z6Q9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220542.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2750"/>
    <dbReference type="EnsemblBacteria" id="AFZ54819">
        <property type="protein sequence ID" value="AFZ54819"/>
        <property type="gene ID" value="Cyan10605_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2750"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_0_3"/>
    <dbReference type="OMA" id="GGMLGWK"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="12598" checksum="0F1F23E9DE7A201E" modified="2013-03-06" version="1">MVCIPVKNEKIILISPLQLYAKLSQESVTLVDVRELSEYNQGHITGAVLKPTSLLTTQELHNLAQQDNLIIYCRSGKRSSDVAQKLIAMGKNFVFDLEGGILGWQSHHLPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6S2</accession>
    <name>K9Z6S2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220613.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2824"/>
    <dbReference type="EnsemblBacteria" id="AFZ54891">
        <property type="protein sequence ID" value="AFZ54891"/>
        <property type="gene ID" value="Cyan10605_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2824"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3001"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050686_0_2_3"/>
    <dbReference type="OMA" id="EKVQDRQ"/>
    <dbReference type="OrthoDB" id="1750212at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019169">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="371" mass="41164" checksum="BC012E825489413B" modified="2013-03-06" version="1">MLSFLDNFMGGKTNGVGIEIGPDKVTLAQISKKGQQYKLLKYYSLEVPEEIFEEGQIVDSPALAELIDQLLKEAKVKPKQIATAVPMKDAVMRIIPIPAELNDQELRDMVLNHEAALYLPYPREEVDIDYQKLGYFVDEDGIEKVQVLLVATRREVTDLYLETFQQAGLKVSVLEINSFALIRTIKEQLKQFSSSEAVVLVDIEFDTTEIAIICEGVPQFTRTIPIGTYQMQTALAQAMNLPTSKNTELLQEITIPNNPEQTTSASTTSSQTWINPGMDSLLRVLGELVDELRRSINFYLNQSGDVEVVQMLLSGPGAGLAQIDEFFTKKLSLPTMQVDPISALSLSLKEDLSPMQRAGLGTVLGLGMRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z734</accession>
    <name>K9Z734_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220104.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2296"/>
    <dbReference type="EnsemblBacteria" id="AFZ54380">
        <property type="protein sequence ID" value="AFZ54380"/>
        <property type="gene ID" value="Cyan10605_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2296"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2438"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_1_3"/>
    <dbReference type="OMA" id="CIFIGLE"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="370" mass="41589" checksum="C7762AE73C2C0F51" modified="2013-03-06" version="1">MKDNFKFFELWNKIPQWLKIFFLFPLLFLNGFLLFVLIDYLQPLVSFLIIASIIAFLLELVIKLLIKQGVNRSIAITIVLLSALIFLIVNSFILIPLLIQQLNELIINSPTWIKQANQYLISLSDLPIFEKFSINLDGIIQEITNKISSILKTLGTQTLNIVVTTINSVFDVLFIVIFTIFLLIGGDKFWQGLYSFFPEPWNVKIPRYFRQTFKDYFFSRLILVGIASVVRLVVFILLGVPSALLFAFGIGIASLVPLLGGFLTILCTLIIVFKSGKLALFFFVSATIIDQVTDNVVAPRLMGELIGLNPIWLIISLFLGAKIGGLLGIFLAVPVASVIKKIIDDLRPPKMILDESSLKLSANLDDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B0</accession>
    <name>K9Z7B0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6x reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2377"/>
    <dbReference type="EnsemblBacteria" id="AFZ54460">
        <property type="protein sequence ID" value="AFZ54460"/>
        <property type="gene ID" value="Cyan10605_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2377"/>
    <dbReference type="eggNOG" id="COG2099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068627_0_1_3"/>
    <dbReference type="OMA" id="THPYAAQ"/>
    <dbReference type="OrthoDB" id="1726104at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="32091" checksum="630C5C4BE00E9C5F" modified="2013-03-06" version="1">MSGVRCQVSGCRLQVVGVEYIERQFGLMIWLIGGTSESVIIARLLSDLKQDFVVTVTTDSACKLYENINDIQVVVTKLSLAQMRYFISVWQVFAIIDASHPFALEVSQNAIHLVTSSQGLCLSYLRYERETVTTNNHKNVFYYPDLQSLLSDNWILKQKKVLLTIGAKYLHLFKPYHHQAQFYARILPYQSSLELAEKAGFGCDRIIAIRPPLSLELEKALWQLWDIEIVVTKAGGKAGGEDIKYQLAEELKIPLVVIKRPSLNYPLMAKSVEDVKEFLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K9</accession>
    <name>K9Z7K9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2489"/>
    <dbReference type="EnsemblBacteria" id="AFZ54570">
        <property type="protein sequence ID" value="AFZ54570"/>
        <property type="gene ID" value="Cyan10605_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2489"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2638"/>
    <dbReference type="eggNOG" id="ENOG5032S5S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177754_0_0_3"/>
    <dbReference type="OMA" id="WMAVIFV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="11575" checksum="1CDD21B128315234" modified="2013-03-06" version="1">MENQQKYRMICTLTFGDIYGQIIVWLGVIFISLASTLALWSSTRQIYAFATVAIVLVLSLPFLLFAFVTTLFNHIEFVPMEQTESSKSSNRAKFSGKTAQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M0</accession>
    <name>K9Z7M0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220117.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2309"/>
    <dbReference type="EnsemblBacteria" id="AFZ54393">
        <property type="protein sequence ID" value="AFZ54393"/>
        <property type="gene ID" value="Cyan10605_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2309"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2453"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_2_0_3"/>
    <dbReference type="OMA" id="ENLMDMY"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="40871" checksum="6D4CA0A1DCF8D6C6" modified="2013-03-06" version="1">MGQLEVKPNIRTCGINPNHWYVVARSVEVTDKPYCVTLWHENIVIFRNAQGKIKALEDRCPHRQVKLSDGVVVGDDIECAYHGWRFNGEGKCSFVPYLQENQRLPSCKLKAYPVQELDGFIWLFLGDGDSEKIKPMGLPEWEHLNYIASVTTINCPGHFSYLIENLMDMYHGHLHDNYQAWAEANLKEIETTSQRIDVLYTAQSYYRIDKIWSVSQLFFPALRRLHPEPLRVSYIYPHWSSSLGEDFKIYCLFCPIDETTTKAYLIHFTSLQAFWRLHKLPVWFRRFVKNSLFNAAKGLLDGLVEQDIAMIKQEQEAFNRNPLRRNYELNGAIAPVQKLIINQWQSVNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q3</accession>
    <name>K9Z7Q3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XisI protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220480.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2683"/>
    <dbReference type="EnsemblBacteria" id="AFZ54757">
        <property type="protein sequence ID" value="AFZ54757"/>
        <property type="gene ID" value="Cyan10605_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2683"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2848"/>
    <dbReference type="eggNOG" id="ENOG5032GPC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149829_1_0_3"/>
    <dbReference type="OMA" id="ETCLVFD"/>
    <dbReference type="OrthoDB" id="1754843at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16382">
        <property type="entry name" value="XisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014968">
        <property type="entry name" value="XisI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035943">
        <property type="entry name" value="XisI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08869">
        <property type="entry name" value="XisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143847">
        <property type="entry name" value="SSF143847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="113" mass="13467" checksum="0381152563D23F96" modified="2013-03-06" version="1">MGKIIKYRELIKNILTEYDQLVHKSPDYQSETCLVFDENHDHYLWLTVDWKEDKRLKSTHIHIRIKNEKIYIEEDWTEAGIANELLEKGVPKEDIVLAFHDPETRKLTDFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S3</accession>
    <name>K9Z7S3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3182"/>
    <dbReference type="EnsemblBacteria" id="AFZ55231">
        <property type="protein sequence ID" value="AFZ55231"/>
        <property type="gene ID" value="Cyan10605_3182"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3182"/>
    <dbReference type="HOGENOM" id="CLU_212582_0_0_3"/>
    <dbReference type="OMA" id="QTRFKAN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="54" mass="6040" checksum="9DBDE68FDCE16830" modified="2013-03-06" version="1">MGLFGKSKSSGTSVKAHRENLKKNLEHRLTVARSNGDEKLVKQLEQEAAYLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V0</accession>
    <name>K9Z7V0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220922.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3153"/>
    <dbReference type="EnsemblBacteria" id="AFZ55204">
        <property type="protein sequence ID" value="AFZ55204"/>
        <property type="gene ID" value="Cyan10605_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3153"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3360"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_0_3"/>
    <dbReference type="OMA" id="PYECCGL"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18172" checksum="445F0F2F8CC18E08" modified="2013-03-06" version="1">MTVIISEQNLDIIRQQGIKNYPYECCGLLLGVINNCEKKVIKVVPVENDWENQKHLFTKKYDGLKRNLRDSFAINPFTLLKIQKEARNENLNIVGIYHSHPDHSAIPSEFDRDVAHSVYSYLILSVQKKEVTDICSWLLDEDIKFIQEDLIIQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V9</accession>
    <name>K9Z7V9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220989.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55271">
        <property type="protein sequence ID" value="AFZ55271"/>
        <property type="gene ID" value="Cyan10605_3224"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3224"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3437"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259497_0_0_3"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144237" checksum="E493DBB2581AE682" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W9</accession>
    <name>K9Z7W9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221004.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3240"/>
    <dbReference type="EnsemblBacteria" id="AFZ55286">
        <property type="protein sequence ID" value="AFZ55286"/>
        <property type="gene ID" value="Cyan10605_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3240"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_0_3"/>
    <dbReference type="OMA" id="SHEIWFN"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="73" mass="8771" checksum="5CBE7C56F7C54C36" modified="2013-03-06" version="1">MGRLFDFFYQKITQKLNKLGFEFYPMAKEDHEIWFNPKTKAKTTIPHHREIKEGTLRNILKQAKIDVDTFLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z3</accession>
    <name>K9Z7Z3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220982.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3217"/>
    <dbReference type="EnsemblBacteria" id="AFZ55264">
        <property type="protein sequence ID" value="AFZ55264"/>
        <property type="gene ID" value="Cyan10605_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3217"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3429"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_3_2_3"/>
    <dbReference type="OMA" id="GCTMTNM"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939148" evidence="1">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="346" mass="37766" checksum="9EE1514C8E1EBD0B" modified="2013-03-06" version="1" precursor="true">MKRKSFLSYLVVFFATLTLAVACNNPASNIDTNTNAGGGTNGETPVRLGFSAWPGWFPWQVAYDQGIFEQNNVNVDLKWFDGYLESINTLIAEQIDANSQTLGDTVSSIAGGADQVIVLVNDNSTGNDKIIVSEEINTIQDLKGKKVAAEEGTVDHFLLLLGMKEAGLSPEDIEFVPLETGSAAAAFVAGQVDAVAVFAPFTTQALTRPNSKELFSSKDFPGSISDHLVFTRKFVEENPEQVQAMVDSWFATMDYIQANPDQANEIMAQRAGVSVDEYEEYAGGTKLFTIEENLEAFTPGDTMKSLYYSAEQMNKFLVDVGLASQEADLSNIFDDRFVKAYAEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z805</accession>
    <name>K9Z805_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220589.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2800"/>
    <dbReference type="EnsemblBacteria" id="AFZ54867">
        <property type="protein sequence ID" value="AFZ54867"/>
        <property type="gene ID" value="Cyan10605_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2800"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2976"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082867_2_0_3"/>
    <dbReference type="OMA" id="RSYTKQD"/>
    <dbReference type="OrthoDB" id="1228034at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021325">
        <property type="entry name" value="CCB2/CCB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044705">
        <property type="entry name" value="CCB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34943">
        <property type="entry name" value="PTHR34943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11152">
        <property type="entry name" value="CCB2_CCB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="24320" checksum="7529E53BAA1EDB5B" modified="2013-03-06" version="1">MSQKKENQWLKNFPLIAGVIGGFLLMINRLTTVTVLDSQARSDALGVILCAALLLTSVLMRQINPNPPESVTLKGKEAFFLVQDLSSNIKTELAWASHLILTNTVTKSIIIYYQGKTLLRRGILGEMDEFKVGSIVKRVMETQKPVYLVDLKHYPGKIEFDYFPSNIQGLICFPLNRDGVLMVATNIPRSYTKQDETWIQGISEKIALELESCAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z807</accession>
    <name>K9Z807_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220997.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3233"/>
    <dbReference type="EnsemblBacteria" id="AFZ55279">
        <property type="protein sequence ID" value="AFZ55279"/>
        <property type="gene ID" value="Cyan10605_3233"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3233"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3447"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_3"/>
    <dbReference type="OMA" id="ASTDHWR"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="308" mass="35007" checksum="FA37E540EC7694D3" modified="2013-03-06" version="1">MTTINPIHNVEAIAGNYWRWRGQDIYYVQGGENNEKPPLLLVHGFGASTDHWRKNIYQLKKDFQVWAIDLLGFGRSGKPAWEYSGLLWQEQLNDFVSEVIKKPTVIAGNSLGGYACLCVAANSPENIAGVILLNSAGPFSDTIKKSPNLTQKISSWVLKQPLITYFLFQRLRNKKNIRKTLEKVYFDTTAITDQLIEDIYRPSCDEGALQVFASVFRSPQGEKVDRLLEKMQCPLLNIWGDKDPWMRVSERSGKFIQHYDNLTQIHLNAGHCPHDEVPEEVNSLITSWVNETVLPEFKIKLSVKVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z815</accession>
    <name>K9Z815_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ordered locus">Cyan10605_2810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2810"/>
    <dbReference type="EnsemblBacteria" id="AFZ54877">
        <property type="protein sequence ID" value="AFZ54877"/>
        <property type="gene ID" value="Cyan10605_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2810"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2987"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_3_3"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="26452" checksum="AB81A6F47DA0C3D0" modified="2013-03-06" version="1">MMLESQSPQFSIDSYFHFQMTSQKEEKIYNSAVPMVVESSGMGEKVFDIYSRLLRERIIFLGTAIDDKLADSIVAQLLYLEADDPEKDIYIYINSPGGSVYAGMAIYDTMQQIKPDVSTICYGIAASMGAFLLSGGAKGKRLGLPNSRIMIHQPLGGAQGQASDIEIQAKEILYIKNKLNQLLADHTGQPLEKISLDTERDFYMSSTEAQEYGLIDEVIIREGISLPLSRSSVDLSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z823</accession>
    <name>K9Z823_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221012.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3248"/>
    <dbReference type="EnsemblBacteria" id="AFZ55294">
        <property type="protein sequence ID" value="AFZ55294"/>
        <property type="gene ID" value="Cyan10605_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3248"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3462"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_3"/>
    <dbReference type="OMA" id="VHDHERI"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="409"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="499" mass="56516" checksum="B6D592FA0BB5CCD2" modified="2013-03-06" version="1">MNIPLVKEAEKYLDRIAIIDQEKEFTYSDLLFTSHQIASLLLTEKQDLKEERIAYLIPSEFNHVATQWGIWRAGGISVPLCISHPLPELEYVIQDAQVSIIIAHPNFENIAKCLAENNNCRFVSTKEIASVDTLVTLPQIEISRRALILYTSGTTGKPKGVVITHKNILSQVQSLVKAWGWQESDSILHTLPLHHIHGIINVLTCALYSGAKCHLLPKFDPESVWNKIIEGKLTIYMAVPTIYVKLINYWQRCDRILREQMSAGCRKMRLMVSGSAALPVKVLQQWQEISGHFLLERYGMTEIGMALSNPLEGKRFAGYVGKPLPGVTVRLVDEQGNILKENTAGEIQIKGNNVFLEYWQKPEATEKAFKDGWFCTGDLGIIENKNYRILGRLSVDIIKTGGYKVSALEIEEVLRTHPEIKDCAVVGVKDEHWGERVCVAIIAIKDDKLTLDNLRQWAKEKLAVYKIPSKMLMVDDFPRNAMGKVMKPKIIDLFLQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z849</accession>
    <name>K9Z849_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="12" type="ordered locus">Cyan10605_3327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cellular thylakoid membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221089.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3327"/>
    <dbReference type="EnsemblBacteria" id="AFZ55371">
        <property type="protein sequence ID" value="AFZ55371"/>
        <property type="gene ID" value="Cyan10605_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3327"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3542"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_2_3"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="10">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="134" mass="14592" checksum="C3B58AEE913A5CB5" modified="2013-03-06" version="1">MTLTVRVITPDKIVWDQTAQEVILPSSTGQLGILTDHAPLLTSLDVGVMRVRPDNKEWKSIAVMGGFAEVENNEIKVLVNGAQLGETIDKEQAQIAVNEAQTALDQATAKGDRREQMKATQQLKKAKARLQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F1</accession>
    <name>K9Z8F1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220371.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2570"/>
    <dbReference type="EnsemblBacteria" id="AFZ54648">
        <property type="protein sequence ID" value="AFZ54648"/>
        <property type="gene ID" value="Cyan10605_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2570"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_4_3"/>
    <dbReference type="OMA" id="SHMAHWM"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="32316" checksum="76CD8BD77385D03F" modified="2013-03-06" version="1">MPNQVIVNSPSIVHESVHRIIQVYQNYHSTGEDPKPKILDRHLIGLTTNQICYLTLKHNSDKLKEIRYSTEELMIFPAGINHWASWKNSTGIFLSIDNKLFDSYAQKLLDGQTFQLISHLKMRDNFLRELIGAIALVSKKSSEIDDLYLESLFSTLSLHLISNYTEKKTINKSNYGGLAPHKLSIVIDYIKSNLNEKITIATLANLLALSEYHFIRCFKESTGISPYQYILKERLKKAVEMIKKTDENLAHISLICGFSSQSQMSVMLKKHFNLIPKDLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H9</accession>
    <name>K9Z8H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotase, multifunctional complex type</fullName>
            <ecNumber evidence="7">3.5.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220751.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2970"/>
    <dbReference type="EnsemblBacteria" id="AFZ55032">
        <property type="protein sequence ID" value="AFZ55032"/>
        <property type="gene ID" value="Cyan10605_2970"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2970"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3161"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_3"/>
    <dbReference type="OMA" id="WVTAEVT"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="52"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="437" mass="48132" checksum="1B604436CBB0C354" modified="2013-03-06" version="1">MTSDLLIKQAEIVLPEGELLLGDVLVQQGKIAEIGTALHSESARIIDGKGLTLLPGVIDPQVHFREPGLEHKEDLFTASCACAKGGVTSFLEMPNTKPLTTTQAALDDKLNRAKEKCLVNYGFFMGATADNLDDLREASPACGIKIFMGSQHGALLVSTEEEIEPIFAKGDRIIAVHAEDQARIMERRKEFAGISDPAIHSQIQDEEAALNATKLAVKLANKYQRRLHILHLSTGIEAEYLRTHKTPWISTEVTPQHLLLNTEAYEKIGTLAQMNPPLRSPQNNEILWKALLDGVIDCIATDHAPHTLEEKAKPYPHSPSGMPGVETSLVLMLTEAKKGRCSVEQVVKWMCTNPAKLYKIPNKGEIKIGYDADLILVDLNNYRPVLKENLSTKCGWSPFEGWELTGWPVYTIVNGNIALDNGQLCTDVRGKALTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J8</accession>
    <name>K9Z8J8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220771.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2992"/>
    <dbReference type="EnsemblBacteria" id="AFZ55052">
        <property type="protein sequence ID" value="AFZ55052"/>
        <property type="gene ID" value="Cyan10605_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2992"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3188"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_3"/>
    <dbReference type="OMA" id="TCFGRLD"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="3" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="129"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="504" mass="54812" checksum="A8397D61C22454C2" modified="2013-03-06" version="1" precursor="true">MINLLLILPILGAILIAIFPSQKESNIPKKIALITSAIAFFISIIIGLNFDYQAVGLQESLSLDWLTFLGLNYTVGIDGLSLPLIILNCLIVTLTFYNGELDSKTLNKPKLYYILILLLTTCVNGALIAQNLLLFFIFYEIKLVPIYLLISIWGRDKRNYAATKYLLYTAFSGIFVLTGFLGLNFLTNANTFDMEMISSGVLPQAKQILLLLTIVIGFAIKIPIFPLHTWLPDAYTESSTPLSMLLGGVISKLGTYGLIRFGLQLFPDVWGDISPYLAILAVFSAIYGSLVAISQTDIKKMVAYASLAHINFVVLATAAGSSLSILGAICQMFAHGLIVALLFHLVGIIEAKTGTRELSELHGLMNPYRGLPFVGGLMIAAVMASAGIPGMIGFIGEFLSFQGSFSVFPIYTLVCLIATGLTAVYFVILLNRVFFGRMENKTGYLPKVESFERLPAVILAVMIIFFGLQPSFLTNLSVNTSSAISINVPSATAQSVAPQTALFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K9</accession>
    <name>K9Z8K9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="9" type="ordered locus">Cyan10605_2603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220401.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2603"/>
    <dbReference type="EnsemblBacteria" id="AFZ54678">
        <property type="protein sequence ID" value="AFZ54678"/>
        <property type="gene ID" value="Cyan10605_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2603"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2765"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_3"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="621"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="723" mass="82881" checksum="F9B48F47D84D6F61" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P4</accession>
    <name>K9Z8P4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2903"/>
    <dbReference type="EnsemblBacteria" id="AFZ54965">
        <property type="protein sequence ID" value="AFZ54965"/>
        <property type="gene ID" value="Cyan10605_2903"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2903"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3090"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017620_0_0_3"/>
    <dbReference type="OMA" id="TYGEVWF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="720" mass="83593" checksum="961C1EF292C2457B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8P6</accession>
    <name>K9Z8P6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221281.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3533"/>
    <dbReference type="EnsemblBacteria" id="AFZ55566">
        <property type="protein sequence ID" value="AFZ55566"/>
        <property type="gene ID" value="Cyan10605_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3533"/>
    <dbReference type="HOGENOM" id="CLU_2842446_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="65" mass="7650" checksum="86097A7DC1C55457" modified="2013-03-06" version="1">MSKYGIFTEENDSEYYFQIVKPSNGEKKEIITIEKLDMRYPPKFQIEGILKEGLGDLLIFIPFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q2</accession>
    <name>K9Z8Q2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2654"/>
    <dbReference type="EnsemblBacteria" id="AFZ54728">
        <property type="protein sequence ID" value="AFZ54728"/>
        <property type="gene ID" value="Cyan10605_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2654"/>
    <dbReference type="eggNOG" id="ENOG5033QW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690227_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="399" mass="46786" checksum="398B4F4BCD85E213" modified="2013-03-06" version="1">MNKPDFSQKINAKAFERNTKPKPIINKQKNPVSQAELASSPWGKLTFFLDRALGDITPRSFGKKRQYSELAVIQIKCLEKLLNYKTNNWDDLLDELEELDDEEYNKAENFYYHLSRKYSIRPDKFITFWHQKISEFVDLFEKIVNSDQLDLIKLENFANIIDNFNRSRERSFWFLHQLPYYLDEKNKYFLLNSESYQTIIQFGASEYISKFGYQLQKEFNLTRTDIKEKAAQNLVQELGETENNLRAEISRLENENQELEREIQDIKENSLQEAVCTLAKSLQDEQQQPVLDQLFSLYKKIDKLLENNEGLSTQDTLTCFINLENLFKAFSTLNIQPFPPDTEAILEITGEDLDNNKYNYVSGSQFISKEEVKKVKCVACGWKVGEEIVTPAKVEEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8S3</accession>
    <name>K9Z8S3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221306.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3558"/>
    <dbReference type="EnsemblBacteria" id="AFZ55591">
        <property type="protein sequence ID" value="AFZ55591"/>
        <property type="gene ID" value="Cyan10605_3558"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3558"/>
    <dbReference type="eggNOG" id="COG4474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140896_0_0_3"/>
    <dbReference type="OrthoDB" id="1578245at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025475">
        <property type="entry name" value="DUF4326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14216">
        <property type="entry name" value="DUF4326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="13163" checksum="8D54ADD3CBFF2DF7" modified="2013-03-06" version="1">MIKIIKINKYKRLVNEYYIGRNFGNLEGSVLGNKFKINRDGDRKEVIEKYRKWLWKEVKKKEGKVWNELMMLVKEVKAGKDIYLSCWCKPLECHGDVIKSCIEWLIKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8T1</accession>
    <name>K9Z8T1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">Cyan10605_2943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220724.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2943"/>
    <dbReference type="EnsemblBacteria" id="AFZ55005">
        <property type="protein sequence ID" value="AFZ55005"/>
        <property type="gene ID" value="Cyan10605_2943"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2943"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3132"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_3"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="199"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="203"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="412" mass="45055" checksum="27FDF60BB254296B" modified="2013-03-06" version="1">MTNRDGSKSSLHKIHVLVAIGGGIAAYKVCELISQLFKKEAKVKVILTESAQKFITPLTVSTLSRHQAYTDEDFWQPTHSRPLHIALGEWADLMIIAPLTANTLAKLVYGLGDNLLTNTVLASTCPIIVAPAMNTEMWLQKSVQNNWQKLGEDKRYFSLHTNTGLLACDRYGQGRMAEATEIITAIESVIITNGKRDLVGKNVLISAGNTREYLDYVRFIGNPATGKMGIALACACYYRGANVTLVAGNISNELLQYTPPIQIISVVTAQQMEKAMLSNFVQADIILMAAAVADVKPKHYFPDKLGKKSLPQSIELEYVTDIVAQLGEKKKPSQKLIGFAAQTKDIVTPAMSKLIRKKLDAIVTNPIDKDNAGFGSDTNEAIFISKDGTQTVIPSTSKLLLAHRILDLALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8V3</accession>
    <name>K9Z8V3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 4, conserved region-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220516.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2721"/>
    <dbReference type="EnsemblBacteria" id="AFZ54793">
        <property type="protein sequence ID" value="AFZ54793"/>
        <property type="gene ID" value="Cyan10605_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2721"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2887"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_3_1_3"/>
    <dbReference type="OMA" id="WRLLGHF"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="36467" checksum="8A59BAEEA73CB1CA" modified="2013-03-06" version="1">MAFTLTFLVGSFFLSLLLVFIIIQNFSKQLLDIPNERSSHVRPTPRGGGLGFIISFIVAILCLQFVPTLYFTVDPFLLVIILPLAIVGFLDDRLNLPSLVRYGVQLVTAILGVIHYGIFPQPWLTNIGLVGVIIAGILTVIGFTALINFYNFMDGLDGFVVSITIIQLSFIAFYLNQPIWWLLIGALFGFLWWNWSPAKIFMGDVGSTVLGAMIAIALIQVQDTTIAWSTLAITLPITADTIYTLIVRLRRKENIFQAHRTHIYQRLQQSGWSHRQVALTYSILTGAIALLIINLQVIGSWLSLMLVIGLIFFAQSYISRKTTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z934</accession>
    <name>K9Z934_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3176"/>
    <dbReference type="EnsemblBacteria" id="AFZ55227">
        <property type="protein sequence ID" value="AFZ55227"/>
        <property type="gene ID" value="Cyan10605_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3176"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3385"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042257_1_0_3"/>
    <dbReference type="OMA" id="WVEAFGN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="352" mass="39150" checksum="C37ED0847269D454" modified="2013-03-06" version="1" precursor="true">MMKKVLILSTPVGALSSGIGGGVELTIYNLIQEMQGRGHIIKVIAPKGSFFDHADIIEIEGNLHTPAQTQSRQTPVIMPDNSVLANMLDYAYQIQSEYDVIVNFAFDWLPFYLTPFFSTAIAHFISMGSLSDSLDQIMGKIATRFPYQFGVYTKSQADTFPFADKCQCLGSGIDLSLYQFQPQPKKQLAWLGRIAPEKALEDAVKASEITNIPLLIFGKIQDQEYWQTIQNQHPSAPIKYQGFLSTKDLQAQLRDCLGLIMTPRWVEAFGNVAIEALACGVPVISYARGGPAEIVTDGKTGFLVTPDSVEDLAIAIQRLPEINRYDCRQVAEDVYSLTAWGNRFESWLDSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L6</accession>
    <name>K9Z9L6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ordered locus">Cyan10605_3223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220988.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3223"/>
    <dbReference type="EnsemblBacteria" id="AFZ55270">
        <property type="protein sequence ID" value="AFZ55270"/>
        <property type="gene ID" value="Cyan10605_3223"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3223"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3435"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_3"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="344"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="494" mass="54789" checksum="9B18508EEFF1716B" modified="2013-03-06" version="1">MTTATQTKYEAIIGLETHCQLNTNSKIFCSCSTNFDSPPNTNVCPVCLGHPGVLPVLNQEVLNSAIKMGLALQGKIARYSKFDRKQYFYPDLPKNYQISQYDLPIVENGQLEIEIVDPKTQEVTKKIIGITRLHMEEDAGKLVHAGSDRLAGSTHSLVDFNRTGVPLLEIVSEPDLRTGQEAAEYAQELRRLVRYLGISDGNMQEGSLRCDVNISVRPVGQKEFGVKVEIKNMNSFSAIQKAIEYEIERQIEAINEGEAIIQETRLWEEGSQRTISMRSKEGSSDYRYFPEPDLPPLVINEAQLEEISKTLPELPANKRSRYEAEFGLSAYDARVLSDDKDVALYFEAVVANGASVKGAANWITQDIAAYLNSNPDLDINKIALKPEMLAELIKLIEEGTISGKIAKEILPELLEKGGSPKEIVESKGLVAISNPDELSTIIDKILSENPDKLEQYRAGKTKLQGFFVGQIMKATSGRADPKLANQILNQKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9P7</accession>
    <name>K9Z9P7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pheophorbide a oxygenase</fullName>
            <ecNumber evidence="8">1.14.15.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.15.17" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221023.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3259"/>
    <dbReference type="EnsemblBacteria" id="AFZ55305">
        <property type="protein sequence ID" value="AFZ55305"/>
        <property type="gene ID" value="Cyan10605_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3259"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3474"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003927_1_1_3"/>
    <dbReference type="OMA" id="EPPCRLE"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010277">
        <property type="term" value="F:chlorophyllide a oxygenase [overall] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032441">
        <property type="term" value="F:pheophorbide a oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013626">
        <property type="entry name" value="PaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08417">
        <property type="entry name" value="PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="444" mass="52143" checksum="921C5F2479D3D38E" modified="2013-03-06" version="1">MSSEFNFFQNWYPIFPLEDLEINKPQSFTLLGQRLVIWKGEKQKKFQVFLDLCPHRLAPLSEGRIDEETGNLMCSYHGWQFNEKGICTCIPQAENQELVVKNQHNFAVKVFPTREENDLLWVWADANTPDLAEKKPLPLSPQIDKERGFVWSSMVRDLEYDWQTFIENVADPSHVPFAHHGLQGNRKQAQPIAIEIVKSSVNLIEAKVSRLFTTTITFEPPSRLEYAIGFGDKGQQLGLITYCIPIEPGKCRIVAQFARNFAYSLHKITPRWWEHIKTRNAVLDGDMILLHQQERFLQQKLAGENWKNSYKMPTKADRLVIEFRRWFDIYCEGKLPWEKVGFSNFENLKISDNRQQILDRYSQHTKYCKSCRNALKTNYILQIVSIIYFILSLSITAILPDTYRISWGIYLIITGLISVGFFSWLKFWFEPQFYFVDYIHADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W6</accession>
    <name>K9Z9W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221230.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3476"/>
    <dbReference type="EnsemblBacteria" id="AFZ55512">
        <property type="protein sequence ID" value="AFZ55512"/>
        <property type="gene ID" value="Cyan10605_3476"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3476"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3702"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_3"/>
    <dbReference type="OMA" id="LHVEMDV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="356" mass="40451" checksum="EDA77826D91FEC4B" modified="2013-03-06" version="1">MPKKQVILIVDDDPNNFDVIEGLLYKYDYKLFYTSSGKSALAQIDSIKPDLILLDVMMPEMNGMEVCQIVKEKKEWQCIPIIMVTALNDKNDLAQCLEMGADDFISKPVNGIELAARVQSMLRIKSQYDSLQEMLKLREEMTSIIVHDLRNPLTNIILCAGILKMPNLSQEVYRQKLEEINNSGDVLNNQIDTLLQMAKIQSGKMVLAYKETNLSELLNIELKSFHNIAKANNINLILKVPDTTKYFFLDSQLIRRVIQNLLSNAVKFSSENSNIICELNYFDHSFEIKIIDSGKTISDQQKEFIFKKYQIGESVKGVKQIGLGLSFCKMAIEAHNGTIRVENNPEGRGNVFIISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA42</accession>
    <name>K9ZA42_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221302.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3554"/>
    <dbReference type="EnsemblBacteria" id="AFZ55587">
        <property type="protein sequence ID" value="AFZ55587"/>
        <property type="gene ID" value="Cyan10605_3554"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3554"/>
    <dbReference type="eggNOG" id="ENOG5033M47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537541_0_0_3"/>
    <dbReference type="OMA" id="MPLAISE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="20171" checksum="D3A6686546BF62B9" modified="2013-03-06" version="1">MLNIPHHKVRNQNSEVRTNSNKSKLEELIELRKKVNQLEQLIQEIMPLAISEAIDIMGNEETVNGKNVVYSQKNKGKITVTFRKQYPTIKDNTTLKRLDEDIKAELQLLTQKHSSQLSNLDTQLAELDNTIAQLETEKEKLMTNKRLINLKTRFNTERENGMELVPNLSVYIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA44</accession>
    <name>K9ZA44_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221183.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3425"/>
    <dbReference type="EnsemblBacteria" id="AFZ55465">
        <property type="protein sequence ID" value="AFZ55465"/>
        <property type="gene ID" value="Cyan10605_3425"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3425"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3650"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032040_0_0_3"/>
    <dbReference type="OMA" id="YLIAAND"/>
    <dbReference type="OrthoDB" id="267291at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="629" mass="73536" checksum="2193201B43BEE829" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA61</accession>
    <name>K9ZA61_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein PatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls heterocyst pattern formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nitrogen starvation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220966.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3200"/>
    <dbReference type="EnsemblBacteria" id="AFZ55248">
        <property type="protein sequence ID" value="AFZ55248"/>
        <property type="gene ID" value="Cyan10605_3200"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3200"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031371_1_1_3"/>
    <dbReference type="OMA" id="PFANTIG"/>
    <dbReference type="OrthoDB" id="1201182at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043158">
        <property type="term" value="P:heterocyst differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024186">
        <property type="entry name" value="Sig_transdc_resp-reg_PatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005897">
        <property type="entry name" value="RR_PatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0364">Heterocyst</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="317"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="48750" checksum="785A972EA38847CC" modified="2013-03-06" version="1">MNQEYPPLEILRKICQNKQTGHLQIQTNSVRWNIYLVEGKIQYAQHNLQSIETVKNYLIHLQIPFANTIGSDLRNLSKPFLLLAIVKELVEQNQINREQKNILLRKLTEDAIESFICLPEGQTKWEVNNNLSLMGAPKIFENNGIEGDQIIDSLKGKISQWQKLKPFISSPHQRPSCPNISLLSTKVSGGSLTPSVLQKLVKTMTGESLRNISFLLKQDDFKLAQVLYPYIKHRIIILDPPKSPLDKLPLIPSVSNLSSLRVRNVRGNYFTEKAENISSSVKSTIVSSTNTVNTVKNNLPVSSTIKPSPSIGSKTHKIICIDDSQVMLDTIKDYLGSENYDTLTVANPMQCLPSLFASKPDLILLDLSMPNINGNRLCQILRSSPTFKQVPIIIVSGNINMLTQEKIEAIGANDFLPKPFTKEELLVIVNKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA68</accession>
    <name>K9ZA68_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_3452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221208.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55490">
        <property type="protein sequence ID" value="AFZ55490"/>
        <property type="gene ID" value="Cyan10605_3452"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3452"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3676"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="CRALTGW"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ55490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="397" mass="45512" checksum="97F52A035D68C67F" modified="2013-03-06" version="1">MLKAYKYRIYPTDEQKVLLAKTFGCCRWFYNFALDLTNETYKATGKGLSRDEIINKLPQLKKEKEWLSEVPSQALQQVALDLSSAFLNFFEKRAKFPKFKKKGNKQSVRFPQGIKLDGDYLTLPKLKKVYCKVSRLPEGKLKSVTISMTSSGKYFASCLYDDGQDLPEQNSEGKAVGIDLGVKDFAITSDGSKYGNLNYYRKYEQKLAKKQKRLAKKQKGSNNRHKARKAVAKVHEKITRCREDFLHKLSRKLVDENQVIVVENLAVKNMVRNHKLAKSINDCGWGQFCTMLKYKAEWEGKTYIEVDRFFPISKTCNHCLYQVDSLTLDIRRWQCPKCETIHDRDVNAAKNIRDEGLRILAVGHIASASGERVRPSKGTAFVRHLSVKEESPVTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAF0</accession>
    <name>K9ZAF0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221076.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3313"/>
    <dbReference type="EnsemblBacteria" id="AFZ55358">
        <property type="protein sequence ID" value="AFZ55358"/>
        <property type="gene ID" value="Cyan10605_3313"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3313"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3527"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_1_0_3"/>
    <dbReference type="OMA" id="ICGIPTW"/>
    <dbReference type="OrthoDB" id="1961680at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010086">
        <property type="entry name" value="Flavodoxin_lc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038996">
        <property type="entry name" value="FldA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01752">
        <property type="entry name" value="flav_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="18733" checksum="8D605CB710CF72BC" modified="2013-03-06" version="1">MAKIGLFFGTQTGNTETIAESIFEALGGDSIVDLYDVADVDINTLGEYQYLIIGCPTWNVGELQSDWEGLYEDLDEIDFNGKKIAYFGAGDQIGYADNFQDAMGILEEKISSLGGQTVGYWSTEGYDFNESQAVKNGKFVGLALDEDNQSELTEERISSWVAQIKNEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZF9</accession>
    <name>K9YZF9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0179"/>
    <dbReference type="EnsemblBacteria" id="AFZ52336">
        <property type="protein sequence ID" value="AFZ52336"/>
        <property type="gene ID" value="Cyan10605_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0179"/>
    <dbReference type="HOGENOM" id="CLU_2896549_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="6836" checksum="6762DB4860C062B5" modified="2013-03-06" version="1">MSKEDSRCVRPELVILITTPCRLVISTTSPRGKHFITKRGHTLVSNETGGMQTPNVAEAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZK9</accession>
    <name>K9YZK9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ordered locus">Cyan10605_0232</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218118.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0232"/>
    <dbReference type="EnsemblBacteria" id="AFZ52386">
        <property type="protein sequence ID" value="AFZ52386"/>
        <property type="gene ID" value="Cyan10605_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0232"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.241"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_3"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFZ52386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30986" checksum="F4050EA59D3BAD99" modified="2013-03-06" version="1">MPELPEVETVCRGLNYVTSGLVIMGADVLLSRSVAFPDSDSTFVQEVKSQKILQWHRRGKYLLAQLSEGYLGVHLRMTGQLLWVKQDSPLQKHTRVRFFFADNQELRFVDTRTFGKVWLVNQDVAPDSIITGLQKLGYEPFDAQFSVTYFQDKLKRCRRPIKTVLLDQGIVAGIGNIYADEALFVSNIHPQTLACDLSSSQIERLHSAILEVLETAIASGGTTFSDFLHITGVNGNYGGKAWVYGRKGQPCRICSNIIEKIKLGGRSSHFCPQCQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZL8</accession>
    <name>K9YZL8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218091.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0203"/>
    <dbReference type="EnsemblBacteria" id="AFZ52359">
        <property type="protein sequence ID" value="AFZ52359"/>
        <property type="gene ID" value="Cyan10605_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0203"/>
    <dbReference type="HOGENOM" id="CLU_1755807_0_0_3"/>
    <dbReference type="OrthoDB" id="2048602at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938532" evidence="1">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="14790" checksum="9173E78D69790C38" modified="2013-03-06" version="1" precursor="true">MKKTLLALGVAGLGSLLATPAFAQTYSSGSSTIVLMNGASQSVGAEVSLPSGTYFTGGFANELATPAQVDGAVVVTPALEDETEFLAVNEQAFAELVVDPGLPDSIGNLAGFVPSSFTQAAADALVNAADLQEQVSIIRAGAGVDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZY1</accession>
    <name>K9YZY1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin (2Fe-2S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218242.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0366"/>
    <dbReference type="EnsemblBacteria" id="AFZ52511">
        <property type="protein sequence ID" value="AFZ52511"/>
        <property type="gene ID" value="Cyan10605_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0366"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_7_3_3"/>
    <dbReference type="OMA" id="CKAYATS"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11226" checksum="38C0C8B074AFF93D" modified="2013-03-06" version="1">MANSYKIKLINEEKGIDNVIEVNADEYILDAAERQGFNLPYSCRAGVCVSCTAKIVEGTVNHDYDFLKDKEIEAGFFLTCKAYATSDGVIKTHQEDALLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZZ9</accession>
    <name>K9YZZ9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218225.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0347"/>
    <dbReference type="EnsemblBacteria" id="AFZ52494">
        <property type="protein sequence ID" value="AFZ52494"/>
        <property type="gene ID" value="Cyan10605_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0347"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.363"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050695_0_0_3"/>
    <dbReference type="OMA" id="IYDCDFN"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="DUF3641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_SeCys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="PTHR43728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3641" evidence="6">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="329" mass="37658" checksum="AC181279A25E07A2" modified="2013-03-06" version="1">MSFSDSIMSFSERVKHNLPKEKIDILQINLGRKCNISCTHCHVEASPKRTEELSEIACQKILKIIELFPQIKTVDLTGGAPEMNYGFAEIVRVARKFNKEVIVRTNLTIFFENNYEYLPEYFADNQLRVVASLPCYLEGNVDKQRGNGVYNKSVLALQKLNQLGYGYDPNLILDLVYNPVLPQEKKFNLTPRQDNLEENYKKYLKDNFQIKFNNLFTITNLPIGRTKFYLDKFNLTQDYLRFLEANFNSATLPFLMCRNQLSIDYLGNIYDCDFNQMSGLNAVNHQGKKLTLDDILDSNSLDLISQIRTEDYCYGCTAGSGSSCGGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0A7</accession>
    <name>K9Z0A7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218330.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0457"/>
    <dbReference type="EnsemblBacteria" id="AFZ52599">
        <property type="protein sequence ID" value="AFZ52599"/>
        <property type="gene ID" value="Cyan10605_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0457"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.483"/>
    <dbReference type="eggNOG" id="COG1169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_8_4_3"/>
    <dbReference type="OMA" id="WTPIYAE"/>
    <dbReference type="OrthoDB" id="1469584at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="215"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="476" mass="54629" checksum="467877DA0F902CB8" modified="2013-03-06" version="1">MAIIPNHLSVLDYIQEFKKLIFSSSFNIKNNSSPSPIFSISCEVEPIDPLIFISVLQTDKQPVFYWQNQRKKEAIAAIGAIKSLNIDKNICQQDKDIDRFQKCQEFINNNQKLIHILNKDQDNYQPHFFTYFRFFEQSHNFDNKSFPLATIFLPFIQLIKKDNKYSVTINTYNQNKKEILDYLKDNFSEKIELNYKVNYSQENKINSHLENAKYQGFIDKVNKGLEAIKSEKLTKIVVAHALEIKTENKFNIVKSLENLRNNHPDCYIFSIGNEDQEYFIGASPERLLSIKDNQLVSDALAGSAPRGKNEDEDFLIGNNLLDSEKEKREHQAVSNFIFNQLSAMGLQPKKASLQLLKLSNIQHLWTPIYAEIKEEINPLEIVRQLHPTPAVAGVPIEVACQEIETSEKFDRSLYAAPIGWLDLQGNCEFIVGIRSALIKENYARLYAGAGIVTGSKPEQELTEIKLKFQALLQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0G5</accession>
    <name>K9Z0G5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="4" type="synonym">rpl2</name>
        <name evidence="7" type="ordered locus">Cyan10605_0522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218395.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0522"/>
    <dbReference type="EnsemblBacteria" id="AFZ52664">
        <property type="protein sequence ID" value="AFZ52664"/>
        <property type="gene ID" value="Cyan10605_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0522"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.552"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_3"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="30987" checksum="18F51B2DC5571308" modified="2013-03-06" version="1">MGVRTYRPYTPGRRQAVSSDFSEITKSTPEKSLTKYIHRKKGRNNRGVITSRHRGGGHKKLYRIIDFKRDKRDIKAEVLAIEYDPNRNARIALVQYEDGEKRYILAPAGIQVGATIIASETAPYEIGNALPLEKIPLGTEVHNIELTRGKGGQIVRAAGGFAQLMAKDGDYVTLRLPSKEVRMVRKECYATIGRVGNIEARNLKLGKAGKSRHLGIRPHVRGSAMNPCDHPHGGGEGRAPIGRSGPVSPWGQPALGKKTRKKKKLSNKYIVRRRNAGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J3</accession>
    <name>K9Z0J3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0560"/>
    <dbReference type="EnsemblBacteria" id="AFZ52701">
        <property type="protein sequence ID" value="AFZ52701"/>
        <property type="gene ID" value="Cyan10605_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0560"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.591"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="NYEFFGD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="239" mass="27667" checksum="9D719C26DE8AA102" modified="2013-03-06" version="1">MSMRILLVEDEIELATTLQGILQQEGYHVEISHDGEQGLNLALKQNYDLLILDWMLPHKSGLEICQQIRHQPFFIKTPVLFLTAKDTLDDRVLGLDAGADDYLVKPFELRELLARVRALLRRVSTITDSQEEQNKLETRIKVADLEIEVESQIAYRNGKMIKLSEKEVKLLQFFSQNLHQLVTQEEIYNYLWTTEEAPSSNVVAAMVRLLRKKIESNQEPPLIHTIYGKGYWFGLEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z127</accession>
    <name>K9Z127_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS/PAC sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0101"/>
    <dbReference type="EnsemblBacteria" id="AFZ52260">
        <property type="protein sequence ID" value="AFZ52260"/>
        <property type="gene ID" value="Cyan10605_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0101"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276568_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="421"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="623"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="693"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="946"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1150" mass="133111" checksum="177BEF8BED202108" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z152</accession>
    <name>K9Z152_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218022.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0133"/>
    <dbReference type="EnsemblBacteria" id="AFZ52290">
        <property type="protein sequence ID" value="AFZ52290"/>
        <property type="gene ID" value="Cyan10605_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0133"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050982_0_1_3"/>
    <dbReference type="OMA" id="FARHKND"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="350" mass="38625" checksum="8F8887A933EF6D0A" modified="2013-03-06" version="1">MQNSLNRIILGSVFFCVTIVVAIVGYMTFGWTLLESTYMVVITIFGVGYGEVKPLQTPAEKIFTISVIIAGTSSAIYGLGGFISMITEGEINRALEAQRQRKTISNLENHVIICGFGHIGQVLAQQLEEVAENFVVIDNNHEIIELAKSRNYLTEEGDATDENILTKVGIDKARVLVTVLASDASNVFITLTARELNHNLIIIARGEFPSTEKKLRLAGANHVVLPASVSGMRMANLITSPNTNDFFQHPEEQSYLNDLLKQLEVQIEELSLADTSPLVGKTVKELEIRGKGSFLVVAIRRYSGDLISHPASTLILNRGDILIVLGHQADLPQFARYYRLNRFLSTNQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z156</accession>
    <name>K9Z156_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218027.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0138"/>
    <dbReference type="EnsemblBacteria" id="AFZ52295">
        <property type="protein sequence ID" value="AFZ52295"/>
        <property type="gene ID" value="Cyan10605_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0138"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.142"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057297_2_0_3"/>
    <dbReference type="OMA" id="QGVHLMA"/>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="293" mass="32371" checksum="AAAD3DB9050AD26D" modified="2013-03-06" version="1">MTKLENAIASKEFIITAEVTPPKGGNPERMLEVARLLKDRVHGVNITDGSRAVLRMSSIASCVLLQREGIEPICQMTGRDRNSIALQADLMGAYSLGIRNILALTGDPLKAGDHPQAKAVFELESVRLLKLIGQLNEGFDLNNKTLPDGNLNLFAGAAVDPQLKSWSGLQRRFEQKIKAGAKFFQSQLITDFDKLDRFMNEIAKGCDRPILAGIFLLKSAKNARFINKNVPGVEIPEHIINRLEKAENPLLEGMTIAAEQIKDAQQICQGVHLMAVKREDLIPQILDLAKIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z198</accession>
    <name>K9Z198_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218238.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0362"/>
    <dbReference type="EnsemblBacteria" id="AFZ52507">
        <property type="protein sequence ID" value="AFZ52507"/>
        <property type="gene ID" value="Cyan10605_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0362"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.381"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_3"/>
    <dbReference type="OMA" id="GKQPELC"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="310" mass="34631" checksum="304CD5AD7664A4D4" modified="2013-03-06" version="1">MRIEQIRAFVAVSETGSFGQAAKLCGVTQSTISRQVQGLESHLNTALFHRQAQAKLTVSGEKLLPHAKRICQEWDKIEYKIQQLLQGEQPELCVAGIHSVCAYFLPPILQSFCQSHPQVQLRVTALGSDRALKVLRDGLVDVAVVMNNKYLTSTSEMVCKHLYYEPIQVLVSSTHPLATKDSVTIVDLAPYSQVIFKDGYGMQRIVQEVFAGHGFDLEVAMELNTLDAFRGVIRQGNFIALLPESALQESKSDPSLSIIPITLKSHQSQIQQLTREVVLITTKDRLQIPTVKDFFNLVYDYAKAMKNQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1A5</accession>
    <name>K9Z1A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218717.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0854"/>
    <dbReference type="EnsemblBacteria" id="AFZ52986">
        <property type="protein sequence ID" value="AFZ52986"/>
        <property type="gene ID" value="Cyan10605_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0854"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_3"/>
    <dbReference type="OMA" id="HAKVPET"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="5">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="240"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="52587" checksum="E9DC6D73C25D2B79" modified="2013-03-06" version="1">MTQKWEDSQPKNGKLFVTSNDSKKNDFPNREISPQTQEKKQGNNLILGLLLGVIGTFIIMKVIETKTSTTANNVSTPQTQIPATSSSQTITTVKAQITQIANKVETTGTVSAFELIPVMSSASNLQIKEVLVDEGDIVAQGDILLRLDDTILKAELAQAQAGVSQSQARLAELKAGTRKEELARAKENVTFAQAEVNQAQSDLQLAVTRLERNKQLEAEGAIPRDRLDEFINNKLSQESNLIQARARLAEAKQRLQELEAGEREEVITQAEANLREAKARVKLIQARLAETIITAPTGGKIAERNARVGDVTSSFNSQKLFTIIEDKRLELQLKVPENQLKDIKTGQVVNIYSSANDNIQLKGKVRDINPIIDSESRQGIVNVDLPPDTNLQPGMFVQATIITSIKPSLTVPMAAVLPQVDGKGLVYTLQTDNTVKSQPVTLGEIIGNDRVEILSGLEVGDTIALQGVNYLQDGSQVKVVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B5</accession>
    <name>K9Z1B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ52360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="Cyan10605_0204"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005355005" evidence="1">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="529" mass="53392" checksum="400B4AAC7B89693F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0876"/>
    <dbReference type="EnsemblBacteria" id="AFZ53006">
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        <property type="gene ID" value="Cyan10605_0876"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5032YVY">
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    <dbReference type="OMA" id="EARVEYH"/>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="101" mass="11660" checksum="901F962483C42D85" modified="2013-03-06" version="1">MANITENKQAYQEKVKAQIDKINAQIEQMSAKAKEAKADVAVEYNNQLEKLYAQRDAVQSKFKELQDAGEEAWGEIQKGFDKAWNELNDSFNQAWSKFQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D2</accession>
    <name>K9Z1D2_CYAAP</name>
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        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
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    <dbReference type="STRING" id="755178.Cyan10605_0226"/>
    <dbReference type="EnsemblBacteria" id="AFZ52380">
        <property type="protein sequence ID" value="AFZ52380"/>
        <property type="gene ID" value="Cyan10605_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0226"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.235"/>
    <dbReference type="eggNOG" id="COG1132">
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    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
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    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="589" mass="65641" checksum="084BE7FC0D1F1918" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1P6</accession>
    <name>K9Z1P6_CYAAP</name>
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        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ordered locus">Cyan10605_0505</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFZ52647">
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    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0505"/>
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    <dbReference type="eggNOG" id="COG0361">
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    <dbReference type="HOGENOM" id="CLU_151267_1_0_3"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="75" mass="8578" checksum="C9C0607F752A71C0" modified="2013-03-06" version="1">MSKKDLIEMEGTVTESLPNAMFRVDLDNGFNVLAHIAGKIRRNYIKILPGDRVKVELTPYDLTKGRITYRLKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1X1</accession>
    <name>K9Z1X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218115.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0229"/>
    <dbReference type="EnsemblBacteria" id="AFZ52383">
        <property type="protein sequence ID" value="AFZ52383"/>
        <property type="gene ID" value="Cyan10605_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0229"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.238"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_3_3"/>
    <dbReference type="OMA" id="HIKAYVV"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="27215" checksum="94FD31F33BE40FEA" modified="2013-03-06" version="1">MKLNTDTVQILNQDLLISAYLAQPDSSEELPAVIVVQEIFGVNDHIQDITRRIANEGYIAIAPAIYQRQAPNFTAGYTPEDVKIGREYKNQTKADELLSDIQATINFLYQLPRVKKTGVGAIGFCFGGHVTYLTAILPEIKATASFYGAGIANWCPGSNVPTIARTKDIKGKIYCFFGEKDASIPPEQVTQIESELQKYQIPHQIFRYGEAEHGFMCDRRSSYHQESAQDAWEKALELFKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z252</accession>
    <name>K9Z252_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218205.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0326"/>
    <dbReference type="EnsemblBacteria" id="AFZ52473">
        <property type="protein sequence ID" value="AFZ52473"/>
        <property type="gene ID" value="Cyan10605_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0326"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.339"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_3_3"/>
    <dbReference type="OMA" id="YHVSGLM"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="349"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="433" mass="49842" checksum="17AB4F0B5BEBCCC7" modified="2013-03-06" version="1">MFEQRLFEKYLSIINKFNQEENIIIFLGENDFCNFVSAFFACINSNVSLFLVNPNWGKQEWQQVEKIVTPDLIFGKINYKFSRNKQKKQTRLKGIMIPTGGTSGQIKFAIHTWETLTNSALSFYQFFGNLPINSFCCLPLYHVSGLMQVVRSFISEGDFVFNTFNYLKNNHQSIVNYQDYFISLVPTQLQFFLDKNPFFLQQFKTILVGGASISPQQINLARTYNLPLALTYGMTETASGITILKPEYFTNNNNSSGQVLPHANIISSEKTKDIDEVRQKGFLQYSTYQQNIIAIKATSLFKGYYPHYEEKEIYLTDDVGYFDQEGFLCILGRNSQKIITGGENVFPQEIEKAILNTNLVQDVVIKAEKDPYWGDAIASFYVPKNKGIKPEQIKAKLRGEISNYKIPKIWYCVTEIPRNSQGKVEINKLNRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z258</accession>
    <name>K9Z258_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218945.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1092"/>
    <dbReference type="EnsemblBacteria" id="AFZ53214">
        <property type="protein sequence ID" value="AFZ53214"/>
        <property type="gene ID" value="Cyan10605_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1092"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1156"/>
    <dbReference type="eggNOG" id="COG2954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109545_1_0_3"/>
    <dbReference type="OMA" id="WEVDEFF"/>
    <dbReference type="OrthoDB" id="1469073at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012042">
        <property type="entry name" value="NeuTTM/CthTTM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40114">
        <property type="entry name" value="PTHR40114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016487">
        <property type="entry name" value="CYTH_UCP016487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="156" mass="18271" checksum="F89F2998284AFE11" modified="2013-03-06" version="1">MGIEIERKFLVNLDKWFPPDNGLVYRQGYIYTISGNTVRVRIVGAQGYLTLKGKTKGQTRSEFEYSIPVEEAEEMLQTLCDRPFIEKIRYKILVGNLTWEVDEFLGENKGLTMAEVELTEENQDIILPEWIGEEVTDDLRYYNSYLVNNPFSQWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z278</accession>
    <name>K9Z278_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218229.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0352"/>
    <dbReference type="EnsemblBacteria" id="AFZ52498">
        <property type="protein sequence ID" value="AFZ52498"/>
        <property type="gene ID" value="Cyan10605_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0352"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_3"/>
    <dbReference type="OMA" id="GQLMAIH"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939069" evidence="3">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="174"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="414" mass="44877" checksum="143A37F6E60C6747" modified="2013-03-06" version="1" precursor="true">MNIYSNFIKFSCLLLFLLPLASCGNPPETTAQEEESLPPSARIPSVDIQAVSREFLTPTREYIGTTEPLKEVIIRSQAEGQLLELTVDVGDRILKGQTIASLDDTLLNASLARAQAELISLNSAVTEAQSDVISAQAEVESARVRFQQAQVDANRLQQLYEEGAIAKREVELAQTEAKTAEQTLKSAQSQVKVREAAVETAKGRITSQKAVIAEEKKRLAFTKIKSPSDGYVLERLTEEGNLIQTGGEIISIGDFSQAIVNVAVSELDLAKVALGKTVNVKLDAFPNQTFTGIINQISPAAQGDSRQIPLEILLSNPEGKIKQGLLARVKFTADNPSLTIPESALQVGERDNIVFVVNNQSSETKVIAKEVTLGKRRNGKVEVLTGLNEADKIVSRSSNSLKDNQKVKLSAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z285</accession>
    <name>K9Z285_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase AroH</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0706"/>
    <dbReference type="EnsemblBacteria" id="AFZ52842">
        <property type="protein sequence ID" value="AFZ52842"/>
        <property type="gene ID" value="Cyan10605_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0706"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.739"/>
    <dbReference type="eggNOG" id="COG4401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133236_0_0_3"/>
    <dbReference type="OMA" id="CIRVMMT"/>
    <dbReference type="OrthoDB" id="2021052at2"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="144" mass="16607" checksum="B6778E1960457813" modified="2013-03-06" version="1">MENWQQIGAMSKPLMTKVRAIRGATTADANTIESMREAVAELLTEIETRNQLDYEEIISVIFTVTSDLDATFPAAIARENPQWENVPLLDLQQMQVRGSLEKCIRVLIYFNTDKPQAEIYHPYLRKARNLRPDWNLTHMIMGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D1</accession>
    <name>K9Z2D1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroE</name>
        <name evidence="7" type="ordered locus">Cyan10605_0575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218446.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z2D1"/>
    <dbReference type="STRING" id="755178.Cyan10605_0575"/>
    <dbReference type="EnsemblBacteria" id="AFZ52715">
        <property type="protein sequence ID" value="AFZ52715"/>
        <property type="gene ID" value="Cyan10605_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0575"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.607"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_3"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="287" mass="31847" checksum="2697270E0EDD10F1" modified="2013-03-06" version="1">MQITGKTKLLGIIGNPIEHSMSPVFQNSAIASLNLDYIYVPFAVEKENLQELFNTFKAVKIRGFNVTIPHKENVLPFLDYITETAKIIGAVNTVWLTENNQWHGTNTDIDGFISPLKSLDKNWANITPLVLGNGGASRAVIVGCSELGCREIKIVGRNLDKLKQFKASFANTTLKAEISIYTWDELTDLIPHSQLIVNTTPMGMYPHISQSPLTSSQAQLICEDAIAYDLIYNPRPTLFLQQAEKQGAKIIDGSEMLVQQGAVAFEIWTHHPAPVAVMRESLLQILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E8</accession>
    <name>K9Z2E8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52907">
        <property type="protein sequence ID" value="AFZ52907"/>
        <property type="gene ID" value="Cyan10605_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0774"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157332_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15816" checksum="588C5A70FDD8CC28" modified="2013-03-06" version="1">MIKAIIADTIPLYALVDSSDQYYGKARSELLKIQQLKIQVIIPYPIALECYSLVLYRLGNQNAHRFAQQIKDSAQLIQPTNEDYHLAWQKIKQYSDQKITLFDAVTATISQRLNYPVWTYDYHFDLMSIPIWRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J2</accession>
    <name>K9Z2J2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219098.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1251"/>
    <dbReference type="EnsemblBacteria" id="AFZ53369">
        <property type="protein sequence ID" value="AFZ53369"/>
        <property type="gene ID" value="Cyan10605_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1251"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1319"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_6_0_3"/>
    <dbReference type="OMA" id="NCDGAIM"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="3">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="4">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="513" mass="56913" checksum="710806189AED4D20" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2K0</accession>
    <name>K9Z2K0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxysome assembly protein CcmM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbon dioxide concentrating mechanism protein CcmM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_0825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218688.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0825"/>
    <dbReference type="EnsemblBacteria" id="AFZ52957">
        <property type="protein sequence ID" value="AFZ52957"/>
        <property type="gene ID" value="Cyan10605_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0825"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.868"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019008_0_0_3"/>
    <dbReference type="OMA" id="RFKTKSW"/>
    <dbReference type="OrthoDB" id="448757at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017156">
        <property type="entry name" value="CcmM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037250">
        <property type="entry name" value="CcmM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="SSF55239"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RuBisCO_small" evidence="10">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_small" evidence="10">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_small" evidence="10">
        <location>
            <begin position="455"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_small" evidence="10">
        <location>
            <begin position="581"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="189"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037250-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="672" mass="72880" checksum="7631B973E4A9B740" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2X5</accession>
    <name>K9Z2X5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">Cyan10605_0557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218429.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0557"/>
    <dbReference type="EnsemblBacteria" id="AFZ52698">
        <property type="protein sequence ID" value="AFZ52698"/>
        <property type="gene ID" value="Cyan10605_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0557"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.588"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_2_1_3"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="280" mass="30765" checksum="6AF9E4B540CF1C37" modified="2013-03-06" version="1">MTLKFSKYHGLGNDFILIDNRHQSQPLVSQEDAVKMCDRHFGIGADGVIFVLAGEGDTDYTMRIFNSDGSEPEMCGNGIRCFAQFITELEGKEEIGKTYRIHTLAGLICPTIMGNGQVKVDMGEPQLEAEKIPTTLGKTGEKVVNESLIVGDRTYHVSCVSMGNPHCLVFVEDIEQINLNEIGSKFENHPVFPQKTNTEFIQIISHNYLKMKVWERGAGITLACGTGACATVVAGVLNERCDRISTVELPGGCLEIEWSEKDNHVYMTGPATKVFSGQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z342</accession>
    <name>K9Z342_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218868.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1008"/>
    <dbReference type="EnsemblBacteria" id="AFZ53137">
        <property type="protein sequence ID" value="AFZ53137"/>
        <property type="gene ID" value="Cyan10605_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1008"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1066"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_7_2_3"/>
    <dbReference type="OMA" id="TLNRITW"/>
    <dbReference type="OrthoDB" id="2079628at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8172" checksum="12DD368AF83EEFB3" modified="2013-03-06" version="1">MTVYQLVQIVWLVSAFLLILLVLLHSPKGDGLGGIGGQAQLFSSTKSAEATLNRVTWILSLTFISLTVVLSAGWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z350</accession>
    <name>K9Z350_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein (LYSE/YGGA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1527"/>
    <dbReference type="EnsemblBacteria" id="AFZ53636">
        <property type="protein sequence ID" value="AFZ53636"/>
        <property type="gene ID" value="Cyan10605_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1527"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_2_2_3"/>
    <dbReference type="OMA" id="PQFINPH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="209" mass="23074" checksum="F7711338B8C6B385" modified="2013-03-06" version="1" precursor="true">MMNISLTFSSAIALFTAMVILASIPSMSVLTVSTRTITHGLTHGIWTAMGIVSGDILFLIVAIYGLSIFAGINIFFSLIKYIGALYLLWLGLSLWRKTPVNQILVKSNEKSSFIASFLMGFVITTADLKAILFYLSFLPAFLDLSSVSLMDTFIIILITIIAVGGIKFIYAFFSYKTGSVLKKNNNFKYINYVAGTMMIAIAFFLLFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z351</accession>
    <name>K9Z351_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na-Ca exchanger/integrin-beta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218878.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1021"/>
    <dbReference type="EnsemblBacteria" id="AFZ53147">
        <property type="protein sequence ID" value="AFZ53147"/>
        <property type="gene ID" value="Cyan10605_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1021"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1082"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226274_0_0_3"/>
    <dbReference type="OMA" id="SAPHIMN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="844"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2534"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2641"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2552"/>
            <end position="2575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="2954" mass="309717" checksum="20E908883FAC1CC6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z356</accession>
    <name>K9Z356_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218883.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1026"/>
    <dbReference type="EnsemblBacteria" id="AFZ53152">
        <property type="protein sequence ID" value="AFZ53152"/>
        <property type="gene ID" value="Cyan10605_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1026"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_4_3"/>
    <dbReference type="OMA" id="WSTPQAT"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="200" mass="22909" checksum="39CA8751A65EFA76" modified="2013-03-06" version="1">MTWQILVADDDLIIRNLLKECLELQNYSVILAGNGQEAISLAKIYHPHLLISDIIMPLKNGFELVKELRDIKEFELLPVIFLTNKDGIQDRVNGYQAGCDIYLEKPFNPPELIAIIKHLFTRHNVQLSQTKSDVKLDISLTNRERQVLRLLIKGFSNLRIGEELYLSSKTVEKYVSNLLRKTGSTNRTELASFACKNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z358</accession>
    <name>K9Z358_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAB/ELIP/HLIP superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218751.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0890"/>
    <dbReference type="EnsemblBacteria" id="AFZ53020">
        <property type="protein sequence ID" value="AFZ53020"/>
        <property type="gene ID" value="Cyan10605_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0890"/>
    <dbReference type="eggNOG" id="ENOG50334GG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171075_6_0_3"/>
    <dbReference type="OrthoDB" id="2072465at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="47" mass="5058" checksum="E851A1FB6273FFEB" modified="2013-03-06" version="1">MENKEGKLGFTAFAENWNGRLAMLGFLIGIATELMTGKGILAQLGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z399</accession>
    <name>K9Z399_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218579.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0712"/>
    <dbReference type="EnsemblBacteria" id="AFZ52848">
        <property type="protein sequence ID" value="AFZ52848"/>
        <property type="gene ID" value="Cyan10605_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0712"/>
    <dbReference type="eggNOG" id="ENOG502ZW5U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140918_0_0_3"/>
    <dbReference type="OMA" id="AGNFNYN"/>
    <dbReference type="OrthoDB" id="1418281at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="245" mass="27236" checksum="9FB951C676C17FDF" modified="2013-03-06" version="1">METTSNIQTQPQGTPVLQDIEELTISLVIKNFNPTLLSYEFLTMSGIVPNTWELARQPVVNPRASQISFKNGVNIVAQGNSLSFIEGLGNKEVSQLQFAKVAQLYVEKMPNAEYQGLSISPKVIIPFGEGEEEGKNFINDTFLNAGSWRNFGNTTPQASLNLFYQLDKCRLTVNINPARLQQPNNVAISAVLFAGSFNYLLGENPVASLTSQINQWEADLTTFRELVYQQILQKAPKTNVSLFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A9</accession>
    <name>K9Z3A9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218933.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1079"/>
    <dbReference type="EnsemblBacteria" id="AFZ53202">
        <property type="protein sequence ID" value="AFZ53202"/>
        <property type="gene ID" value="Cyan10605_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1079"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1142"/>
    <dbReference type="eggNOG" id="ENOG502ZB7Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_4_0_3"/>
    <dbReference type="OMA" id="HLFFTYQ"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="261" mass="31438" checksum="F833ABA9BA152A50" modified="2013-03-06" version="1">MNYFSRQQLFSKIYSHAVGVLGFKNQDVILTSFPKSGNTWVRFFFCNLISLIYWDGKIVNFKILDETMPEFGVNNLLNPWKYTKLPRIIKTHKSYLPFFSDKKTILIMRDPRDVMVSYYYFASNKKTTNFDGSFSEFIRNKKFGLQSWFRYHKSWEHINKETIFYEELKNNDKNEFFRMLNFLEISLPESIISEAIILSRFEKVKHNEEKTKHYKEKENKEGFAFTRKGSVGDWINYFSEQDLSYYHGLADQYCLQNFRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D2</accession>
    <name>K9Z3D2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Thf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thf1</name>
        <name evidence="3" type="ordered locus">Cyan10605_1582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in photosynthetic membrane biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1582"/>
    <dbReference type="EnsemblBacteria" id="AFZ53691">
        <property type="protein sequence ID" value="AFZ53691"/>
        <property type="gene ID" value="Cyan10605_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1582"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1680"/>
    <dbReference type="eggNOG" id="ENOG502Z86M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079763_1_0_3"/>
    <dbReference type="OMA" id="MVEMHLL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01843">
        <property type="entry name" value="Thf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017499">
        <property type="entry name" value="Thf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34793">
        <property type="entry name" value="PTHR34793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11264">
        <property type="entry name" value="ThylakoidFormat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03060">
        <property type="entry name" value="PS_II_psb29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="234" mass="27409" checksum="C7AAC82F3A605A74" modified="2013-03-06" version="1">MLTKLLSNILFFVDKNRTVSDTKRSFYQHHQRPINSIYRRVVEELMVEMHLLAVNVDFNPDPIYYLGVYQSFQQFMQGYKPESDKESIFNALCQSIENNPQEYISKSQTLLNFVEGKSAQEILDWLLNPSGEGDLEAVASHWRSNLENPRFKYSRLFAIGFYTLIEKGDGEFIKDESKFTDFIQPLIDKLQLPVEKLKKDLDLYRSNLEKMNQMLSVMADVLEAERKKKQAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K8</accession>
    <name>K9Z3K8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219513.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1681"/>
    <dbReference type="EnsemblBacteria" id="AFZ53786">
        <property type="protein sequence ID" value="AFZ53786"/>
        <property type="gene ID" value="Cyan10605_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1681"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066014_0_0_3"/>
    <dbReference type="OMA" id="KFWPAIN"/>
    <dbReference type="OrthoDB" id="1652111at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939074" evidence="2">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="282" mass="31618" checksum="EFD20F2ACC324E82" modified="2013-03-06" version="1" precursor="true">MLFRSKIFSILLSLGVVSVCPSVVKAQTLLPYTPELNSEYLDNYGFQLIQDAVKLIHFREFDLASSRARLAVQLSPNHYETWFILGTLEIQTGQIEQGVNALLEAKKLAPEESEVLFSLGNAYFQLAEYESAVKELKAGLKISDEVPQAYFDLGNAYLKLNQYGEAITAYQESIKLESQFWPAINNIGLVEYEQGKTNEAIASWRKALEIDSQQAEPTLAIAVAMYSQGKQQEGIKLAQQALSLDNSYGEIDFLIENLWGENLIEDTRKLFANSEIASLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V1</accession>
    <name>K9Z3V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Allophycocyanin, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_1307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cellular thylakoid membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219151.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1307"/>
    <dbReference type="EnsemblBacteria" id="AFZ53422">
        <property type="protein sequence ID" value="AFZ53422"/>
        <property type="gene ID" value="Cyan10605_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1307"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1380"/>
    <dbReference type="eggNOG" id="ENOG502Z8IM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="LRDMDYF"/>
    <dbReference type="OrthoDB" id="1652060at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12126">
        <property type="entry name" value="APC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006245">
        <property type="entry name" value="ApcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34011:SF3">
        <property type="entry name" value="PTHR34011:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01337">
        <property type="entry name" value="apcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="11 12" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="8 12" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 12" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ53422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="19001" checksum="12284B237302F871" modified="2013-03-06" version="1">MLVDAVTSLIKNYDVTGRYLDRNALDSLKSYFQSGTTRIKLATMINGNSPDIVKNASRQLFEEVPELIRAGGNAYTTRRYSACLRDMDYYLRYASYALVAGDNAILDERVLQGLKETYNSLGVPVGPTVRGIQIMKEMIKDMAFQAGMDDVNLVDAPFDHLTRELSDISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3W4</accession>
    <name>K9Z3W4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219551.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1721"/>
    <dbReference type="EnsemblBacteria" id="AFZ53824">
        <property type="protein sequence ID" value="AFZ53824"/>
        <property type="gene ID" value="Cyan10605_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1721"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1828"/>
    <dbReference type="eggNOG" id="ENOG502Z9A3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721370_0_0_3"/>
    <dbReference type="OMA" id="HECTHYF"/>
    <dbReference type="OrthoDB" id="1568365at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="390" mass="45574" checksum="F1AB2E0CF5AF7D56" modified="2013-03-06" version="1">MDKIQSRYKTLTKFKLNESEIEELLTYNENKFKQNSNINDFISFPLKSEPHVKIWQNYKTLADKIGTNNSLTFPLVQLKFPVREGMSQNEQYLRAVRKGECEENFRFEGGLQLTDPDNLQLEIKDTLAGAIPIIIAPNRQDFELLIQAITKKNEPVTIPPSMGACIIGGYNNWDRIKQYRLEWEKNNPNHCTQEDWNQEFKRLIPQKSLYQDRFIILSQGFYSNVSATQLGLTEQQWQKLSLTIRLEHECTHYFTRRVLNYMGNNLLDELIADYQGIVAALGYFRADWFLHFVGLESFPNYRQGGRLENYRGNPPLSDQAFKILQNLVKTAAENLEQFHNKYFNSTPTKQESISLLMALTTLTLEELASDDFETLVQESINYQKKFFKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z400</accession>
    <name>K9Z400_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219591.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1762"/>
    <dbReference type="EnsemblBacteria" id="AFZ53864">
        <property type="protein sequence ID" value="AFZ53864"/>
        <property type="gene ID" value="Cyan10605_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1762"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1870"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_2_0_3"/>
    <dbReference type="OMA" id="CIERPIA"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="185" mass="21456" checksum="48B3349D22D35000" modified="2013-03-06" version="1">MLTLPRKKFALEEYHQIIASGVLKEDYLIELINGEIFEMSPVGFRHASCVKKINYLFAEKLGSKVIIGVQDPIKLNDNSEPQPDIVLLKPRHDFYANQHPTVEDIFLLIEVADSSIEYDRTFKIPIYAENKVQEVWLVDLNQNLLEVYQNPQTNYYQNIKKLSSQDSITLTQPETITVKLDRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z422</accession>
    <name>K9Z422_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219049.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1201"/>
    <dbReference type="EnsemblBacteria" id="AFZ53320">
        <property type="protein sequence ID" value="AFZ53320"/>
        <property type="gene ID" value="Cyan10605_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1201"/>
    <dbReference type="HOGENOM" id="CLU_2421989_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10632" checksum="8BCD3075BBE83FEB" modified="2013-03-06" version="1">MNSITAIPQLSESQSYQQSESFYKNLVESELHKILHYYNLVNGKEEKAQGVWFTVIFGTKNLDYKSHLEEAGFKVKVIPYLNNFTEQQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z446</accession>
    <name>K9Z446_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219079.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1231"/>
    <dbReference type="EnsemblBacteria" id="AFZ53350">
        <property type="protein sequence ID" value="AFZ53350"/>
        <property type="gene ID" value="Cyan10605_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1231"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1299"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025669_0_0_3"/>
    <dbReference type="OMA" id="IWELFPG"/>
    <dbReference type="OrthoDB" id="416080at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="661" mass="76217" checksum="00848CC9EBBC779B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z448</accession>
    <name>K9Z448_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219636.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1807"/>
    <dbReference type="EnsemblBacteria" id="AFZ53909">
        <property type="protein sequence ID" value="AFZ53909"/>
        <property type="gene ID" value="Cyan10605_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1807"/>
    <dbReference type="eggNOG" id="ENOG5032YB3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180777_0_0_3"/>
    <dbReference type="OMA" id="ELTCEKQ"/>
    <dbReference type="OrthoDB" id="2054552at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="9900" checksum="6D071DA200572A7E" modified="2013-03-06" version="1">MITIDLLVRYIPVPLSVEKKEESEAQTLYNQIIEAMKSSETQIVELTCDKQTDKKIAVISDQITGVVISQKDGTSKGNNVPGFFAALAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4I5</accession>
    <name>K9Z4I5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219821.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2002"/>
    <dbReference type="EnsemblBacteria" id="AFZ54096">
        <property type="protein sequence ID" value="AFZ54096"/>
        <property type="gene ID" value="Cyan10605_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2002"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2126"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509783_0_0_3"/>
    <dbReference type="OMA" id="QSEVMWD"/>
    <dbReference type="OrthoDB" id="494208at2"/>
    <dbReference type="Proteomes" id="UP000010480">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ54096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="535" mass="62673" checksum="A6659467AC6B83AD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Q6</accession>
    <name>K9Z4Q6_CYAAP</name>
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        </submittedName>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1272"/>
    <dbReference type="EnsemblBacteria" id="AFZ53388">
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        <property type="gene ID" value="Cyan10605_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1272"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="PFGTICM"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="121"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="580" mass="67447" checksum="E44C256788489244" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4R3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1594"/>
    <dbReference type="EnsemblBacteria" id="AFZ53702">
        <property type="protein sequence ID" value="AFZ53702"/>
        <property type="gene ID" value="Cyan10605_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1594"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1693"/>
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    </dbReference>
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    <dbReference type="OMA" id="IGPAFGW"/>
    <dbReference type="OrthoDB" id="1893911at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021262">
        <property type="entry name" value="DUF2839"/>
    </dbReference>
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        <property type="entry name" value="DUF2839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="8106" checksum="2397F3EBBABDBD1E" modified="2013-03-06" version="1">MGESKRRKENLGDDYGKEEKLYPWLPLTKKQAEDAYKLTTRGAWIGIGLLAFTWITIRFIGPGFGWWSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T7</accession>
    <name>K9Z4T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp fold domain protein, DUF201-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219329.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1489"/>
    <dbReference type="EnsemblBacteria" id="AFZ53600">
        <property type="protein sequence ID" value="AFZ53600"/>
        <property type="gene ID" value="Cyan10605_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1489"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1581"/>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008013_0_0_3"/>
    <dbReference type="OMA" id="PGIPFSH"/>
    <dbReference type="OrthoDB" id="416036at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041356">
        <property type="entry name" value="PGM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="PTHR14465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18105">
        <property type="entry name" value="PGM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="182"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="507" mass="57573" checksum="9CDEFC56BAECEEC9" modified="2013-03-06" version="1">MVITSSEKERFKELQDKLRNCWQDRDILDEDDTDILVIPSFSIDQRVGRKVAGFLHYEERLLFSLIRLRNPHTRLIYITAQPLSPIIVDYYLQLLPGIPFSHARERLLLLTTYDSSLKPLTQKILERPRLVTKIKNSLRPNKSYMVCFNSTPLEEELSIKLDIPLLASSPELSYWGSKSGSREIFSQCNLLHPEGSQLVFTVDDLIRETAQLLIKKSHLKKVVIKLNEGFSGEGNAVLDISGISPLFSLDISLVKAENLIAQIIHEAKVQGEEETWQSYCDRIPELGVIVEEFIEGEEKFSPSVQGYITPNGKVEILSTHDQILGGDEQQIYLGCSFPAHSGYRLRLQELGIKVGEALAKKGAMERFGVDFLAVKENNKWQLYAIEINLRKGGTTHPFMTLKFLTNGTYNYQDGLFYSPEEKVKYYLASDNLQKPNYHGLLPNDLMDIVTKHRLHFDSSTKTGTIFHLMGALSEFGKLGLTSIGNTREEAVNIYKNIETVLDSETLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W5</accession>
    <name>K9Z4W5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phycobilisome linker polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cellular thylakoid membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phycobilisome linker protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219931.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2117"/>
    <dbReference type="EnsemblBacteria" id="AFZ54206">
        <property type="protein sequence ID" value="AFZ54206"/>
        <property type="gene ID" value="Cyan10605_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2117"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2250"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075505_0_0_3"/>
    <dbReference type="OMA" id="YNSFQTR"/>
    <dbReference type="OrthoDB" id="920849at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008213">
        <property type="entry name" value="CpcD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001297">
        <property type="entry name" value="PBS_linker_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038255">
        <property type="entry name" value="PBS_linker_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016470">
        <property type="entry name" value="Phycobilisome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01383">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00427">
        <property type="entry name" value="PBS_linker_poly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005898">
        <property type="entry name" value="Phycobilisome_CpeC/CpcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01094">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51441">
        <property type="entry name" value="CPCD_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51445">
        <property type="entry name" value="PBS_LINKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="PBS-linker" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CpcD-like" evidence="7">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="286" mass="32409" checksum="548CF2DE453B804F" modified="2013-03-06" version="1">MAITAAASRLGVSAFNDFKPVELRPNWTKEEAQVAINAVYKQVLGNDYIMKSERLSNAESLLCNGSITVRDFVRMVAKSELYKNKFLYNNFQTRVIELNIKHLLGRAPYDESEVIEHLDLYQNEGYEADIDSYIDSEEYSRSFGENVVPYYRGFNTQTDQKTVGFTRMFQLYRGYANSDRAQVGGNKSRLASELGRNGVSAVVNPSGSGEGWAYRPSSKGVTPNQTFRNSTREGRVYRIEVAAMNLPRYPKVRRISREWLVPYEDLSTTLQKIQKMGGKVASITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z4</accession>
    <name>K9Z4Z4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrnC</name>
        <name evidence="4" type="ordered locus">Cyan10605_2155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2155"/>
    <dbReference type="EnsemblBacteria" id="AFZ54241">
        <property type="protein sequence ID" value="AFZ54241"/>
        <property type="gene ID" value="Cyan10605_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2155"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2290"/>
    <dbReference type="eggNOG" id="COG1939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091169_2_1_3"/>
    <dbReference type="OMA" id="AYMGDAI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15232" checksum="645145EE7E59BEEA" modified="2013-03-06" version="1">MFESDDISKVLSQVSPDALAYIGDAVYELYIRTSYLLPSKKIADYHHVVVSKVRAESQATYLQNIYPLLNDIEKDWVRRGRNAVNKSPRRLPLQTYQAASGFETLLGYLYISEPERLEFLLSHLTDVTQKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z559</accession>
    <name>K9Z559_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54316">
        <property type="protein sequence ID" value="AFZ54316"/>
        <property type="gene ID" value="Cyan10605_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2230"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2371"/>
    <dbReference type="HOGENOM" id="CLU_2952686_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="59" mass="7039" checksum="F691D58E73255FEA" modified="2013-03-06" version="1">MFIVREKLKVYKLLFNNRLLPIAYCLLPTLINNLHTQSDKAIFFNHIILTTVEKNLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5G9</accession>
    <name>K9Z5G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219370.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1534"/>
    <dbReference type="EnsemblBacteria" id="AFZ53643">
        <property type="protein sequence ID" value="AFZ53643"/>
        <property type="gene ID" value="Cyan10605_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1534"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1629"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_3"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="34977" checksum="22BB9A60A88D840A" modified="2013-03-06" version="1">MDIKNGFVGTIGNTPLIRLNSFSEETGCEILGKAEFLNPGGSVKDRAALYIIQEAEKQGLLKPGGTVVEGTAGNTGIGLAHICNAKGYKCVIVIPETQSQEKMDLLRTLGAEVRAVPAVPYKDPNNYVKLSGRIAEEMDNAIWANQFDNLANRQAHYETTGKEIWQQTDGKVDGWVAATGTGGTFAGVSLFLKEKNPNIQCVLADPMGSGLYSYVKTGEIKIEGNSITEGIGNSRITANMEGVPIDDAVQIHDNEALRVIYQLLYKEGLFMGGSVGINVAGAIALAKQLGPGHTIVTVLCDGGARYQSRLYNPQWLKSKGLTIPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P8</accession>
    <name>K9Z5P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220198.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2392"/>
    <dbReference type="EnsemblBacteria" id="AFZ54474">
        <property type="protein sequence ID" value="AFZ54474"/>
        <property type="gene ID" value="Cyan10605_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2392"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2539"/>
    <dbReference type="eggNOG" id="ENOG5033KYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181367_2_0_3"/>
    <dbReference type="OMA" id="GIAKYGQ"/>
    <dbReference type="OrthoDB" id="2052925at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="8691" checksum="D576A1902FA840A4" modified="2013-03-06" version="1" precursor="true">MNGKRILFSAIITGMIGFVAGVGIAKYGQANETSLKYDRVVYRNWVRSYGRAGFAIGFVVGAGQEYLRQAKKQRDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z3</accession>
    <name>K9Z5Z3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2068"/>
    <dbReference type="EnsemblBacteria" id="AFZ54157">
        <property type="protein sequence ID" value="AFZ54157"/>
        <property type="gene ID" value="Cyan10605_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2068"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2197"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_3"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="453" mass="51098" checksum="8523D337BF8E918D" modified="2013-03-06" version="1">MPLVFFSVEYNSCICKKSEIIAVIERYTLPEMGAIWTDEYRLKTWLQVEIAVCEAQAELGKIPAEAVEEIKAKANFDVKRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGMTSSDMLDTALALQMVASLNLILECVEETIQAIRYQAQKHRYTIMVGRSHGIHAEPITFGFKLAGWLAEMRRHRDRLVKLRQDVAVGQISGAVGTYANIDPQIEAIACSKLGLQPDTASTQVISRDRHGEFVQQLALLAASLERFAVEIRNLQRTDVLEVEEYFSKGQKGSSAMPHKRNPIRSERITGMARIIRGNAVAALENVALWHERDISHSSVERVILPDTCILTHFMLKETTNLVQNLLVYPENMARNMNVYGGVIFSQKVLLALVSKGMSREDAYRVVQGCAHQAWNTENGNFRKLIENNNEVTELLSQEDINTCFDPNQHLANLDVIYERLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Z7</accession>
    <name>K9Z5Z7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54611">
        <property type="protein sequence ID" value="AFZ54611"/>
        <property type="gene ID" value="Cyan10605_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2530"/>
    <dbReference type="eggNOG" id="ENOG503344V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138991_0_0_3"/>
    <dbReference type="OMA" id="PTHADNI"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17791" checksum="B3D07F37CA3E9278" modified="2013-03-06" version="1">MGHYNGNIKNKIQYKFFTLLLLLIMNNNVDINSINEQRQLRRILAVCRVLDLDHKFLGFTLDLNRSGIKIIVDKNFPSGDEFKIILSPVKEDEEISPDIVVKVEQKWRTSTNEEFDQIGGVIIEVDSPEYIEELIDYCDRRAKERYQLDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z631</accession>
    <name>K9Z631_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Light-independent protochlorophyllide reductase subunit N</fullName>
            <shortName evidence="1">DPOR subunit N</shortName>
            <shortName evidence="1">LI-POR subunit N</shortName>
            <ecNumber evidence="1">1.3.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chlN</name>
        <name evidence="3" type="ordered locus">Cyan10605_1751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:28202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10002"/>
            <dbReference type="Rhea" id="RHEA-COMP:10004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83348"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.3.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Protochlorophyllide reductase is composed of three subunits; ChlL, ChlN and ChlB. Forms a heterotetramer of two ChlB and two ChlN subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BchN/ChlN family.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219580.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1751"/>
    <dbReference type="EnsemblBacteria" id="AFZ53853">
        <property type="protein sequence ID" value="AFZ53853"/>
        <property type="gene ID" value="Cyan10605_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1751"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1858"/>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037170_0_0_3"/>
    <dbReference type="OMA" id="ISCVAWL"/>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016636">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036068">
        <property type="term" value="P:light-independent chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019685">
        <property type="term" value="P:photosynthesis, dark reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00352">
        <property type="entry name" value="ChlN_BchN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005970">
        <property type="entry name" value="Protochl_reductN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000162">
        <property type="entry name" value="P_chlorophyll_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01279">
        <property type="entry name" value="DPOR_bchN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="2">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="53230" checksum="5AD0045973FD7E42" modified="2013-03-06" version="1">MTFTPEKTATPELNFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDISAQLNDYNELKRLCDQIKRDRNPSVIVWIGTCTTEIIKMDLEGIAPQLEQEIGIPIVVARANGLDYAFTQGEDTVLAAMANRCPKEAEVKQIEDKQERNAIQKLLNFGKKQEETVHNEYHEHPPLVLFGSLPDPVVTNLTLELKKQGVKIDGWLPAKRYTELPIIDEGYYVAGVNPFLSRTATTLMRRRKCKLIGAPFPIGPDGTRAWIEKICSVLGVEPQGLEEREAKIWENLQDYVDLIKGKSVFFMGDNLLEISLARFLIRCGMTVPEIGIPYMDKRYQKAELEFLAQTCQEMGVSLPTIVEKPDNYNQLQRIKKIQPDLVITGMAHANPLEARGISTKWSVEFTFAQIHGFTNARDILELVTRPLRRNNNLKDLGWSKLVKEEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z667</accession>
    <name>K9Z667_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219942.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2129"/>
    <dbReference type="EnsemblBacteria" id="AFZ54217">
        <property type="protein sequence ID" value="AFZ54217"/>
        <property type="gene ID" value="Cyan10605_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2129"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2265"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072455_1_0_3"/>
    <dbReference type="OMA" id="NRMFYQK"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="214" mass="24899" checksum="921EFFB32356D9F4" modified="2013-03-06" version="1">MLLQPHQRTKLDQSDDNLFYSFPRFVTHVDENFISQLTDLYRQLLQPQTRILDLMSSWVSHLPPEMEFAHVEGHGMNEEELIRNPRLNSYFIQNLNENPKLPLNDADFDGVLCAVSVQYLQYPEAIFSEIARILKPNGVAIFSFSNRMFYQKAIAVWRDATDRQRIHLVKSYFQSVKEFNTPQIVATQPELPAILQMFGIGGKDPFYGIFARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z682</accession>
    <name>K9Z682_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219810.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1991"/>
    <dbReference type="EnsemblBacteria" id="AFZ54085">
        <property type="protein sequence ID" value="AFZ54085"/>
        <property type="gene ID" value="Cyan10605_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1991"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2112"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602339_0_0_3"/>
    <dbReference type="OrthoDB" id="663180at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="454" mass="50509" checksum="073FC4E038F72317" modified="2013-03-06" version="1">MTINIDPIDNISVDISNIRTVVNLFDNFDDPFTTGKVANFNLTDNSIGNGEINIVLFDQTGEGAPITVNNFINYVNGGRYDYSIIHRSVVTPTPFVIQGGGFTVNNLTLNRVPTNSPIQNEFSEERSNVRGTIAMAKLGDDPNSATSQWFFNLGDNSGNLDNQNGGFTVFGQVLSQRDLNTVDAIASLPVVNASSLNSAFNTLPVNPKNVDVNNPSLNQDEDFIRFESITVQDVAELTFTVERNTNPEVVTATIDTEGNLILDYGSFFKTPLYRFQNQDLPGTYLFVGEEERQNILRNFRNFKEEGLAFKTASQADGDTIATGETDITIKATNLLGESVRDTFNINVTGNIPENENQDQLIRFNRFQNRDIPGTYLYAAEEESRNIRQNYTNFIEEGIAFYTYGADANLGQDIYRFQNTSQPGTYLFVGEEEKNSILANYPQFVLEGVAFEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C3</accession>
    <name>K9Z6C3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219850.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2034"/>
    <dbReference type="EnsemblBacteria" id="AFZ54125">
        <property type="protein sequence ID" value="AFZ54125"/>
        <property type="gene ID" value="Cyan10605_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2034"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2161"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_1_3"/>
    <dbReference type="OMA" id="PIRFIYC"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="242"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="39629" checksum="F4FEED8FEE9F4CD2" modified="2013-03-06" version="1">MDDSFQFDPNTIIFLPNYSQKSERVVNWNEFSFENNNEETIIHLPPRVGKGYNRQINLRGGLTIEIIKVQLKDTMYLERRHESAFPLTAHFYLSGMSMVETLNTSEIKSEYTESKGENYLYHLPDLTEIEKWSCKTEIRIISIYAPIHYFHSFCTEEKTTSLQKLIRGDRTSKFHLSLGKNSPEIVRALHQIYQCPYHGLTRQVYLESKALELFSLQFNSCDLSSVSSQKLSIKKEDLDRVEYAKDILIKSYLNPPSLKELSQKVGLNDRTLKQGFKQLFGTTVFGYLYNYRMEQAQELLRNSNLTIAQIAHSVGYSNPEAFSTAFRRKFAQSPKSYQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K8</accession>
    <name>K9Z6K8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220549.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54826">
        <property type="protein sequence ID" value="AFZ54826"/>
        <property type="gene ID" value="Cyan10605_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2757"/>
    <dbReference type="eggNOG" id="ENOG502ZBXR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014600_0_0_3"/>
    <dbReference type="OMA" id="RGKWIQN"/>
    <dbReference type="OrthoDB" id="1430476at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="286" mass="33136" checksum="2440045B4E2D2B16" modified="2013-03-06" version="1">MAKNYFILNSNQDLEKAYQAIILWFKGQLYEVEGIKQDTYYLIQARKTGTIRTLLGSNLAFKIKIYISSESLNGKKEFVIETGRGKWIQNIAGASFASIFTAGLTIWTGIAMAGWGLWLENQLISYLEKDANFVRVKPKEEGTIKESNNTDYVYEINIEKNSDQQQIINELQTEIDKLEIAFTDEILTEEEFVRKKAILEKQLDDYEVNLLIEEKVKKLQDAFSQGILDQIEYEKKVHDLEANVREKFLTQRKAERNKTKIVKLKEALKNGIITQQEFDRKIAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K9</accession>
    <name>K9Z6K9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">Cyan10605_2096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219910.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2096"/>
    <dbReference type="EnsemblBacteria" id="AFZ54185">
        <property type="protein sequence ID" value="AFZ54185"/>
        <property type="gene ID" value="Cyan10605_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2096"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2228"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_3"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="327" mass="36235" checksum="F3307C1020B03EB6" modified="2013-03-06" version="1">MTATPWTRKHIISLEDFTIDEYDAVLTTASSFKSVLKSRTKKVPALQGQVVANMFFEPSTRTRSSFELAAKRLSADILNFAPGTSSLTKGETILDTAKTYWAMGANIMVIRHSNSGVPLNVAMEMDRLNSGVSIFNGGDGLHQHPSQALLDLFTICSLLDEKNPQLSLLKGKKVAIVGDILHSRVARSNINSLLAGGCEVHLAAPPTLLPSLFLETINSSQKKRLFVHWHLKPALENADFVMTLRLQKERMTDYLLPSLREYHQLFGITHERLQWCNPEVKVLHPGPVNRGVELSSELMDDGKYSLIGEQVTNGVAVRMALLYLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L3</accession>
    <name>K9Z6L3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Phycobilisome 7.8 kDa linker polypeptide, allophycocyanin-associated, core</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_1947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Rod linker protein, associated with allophycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">This protein occurs in the rod, it is associated with allophycocyanin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phycobilisome linker protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219768.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1947"/>
    <dbReference type="EnsemblBacteria" id="AFZ54043">
        <property type="protein sequence ID" value="AFZ54043"/>
        <property type="gene ID" value="Cyan10605_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1947"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2069"/>
    <dbReference type="eggNOG" id="ENOG5032S63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770063_0_0_3"/>
    <dbReference type="OMA" id="LFKITAC"/>
    <dbReference type="OrthoDB" id="1939400at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011134">
        <property type="entry name" value="Allophyco_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011064">
        <property type="entry name" value="Allophyco_linker_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008213">
        <property type="entry name" value="CpcD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01383">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000083">
        <property type="entry name" value="Allophyco_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01094">
        <property type="entry name" value="CpcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54580">
        <property type="entry name" value="SSF54580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51441">
        <property type="entry name" value="CPCD_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 9 10" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="CpcD-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="67" mass="7792" checksum="487CC4E2F642E8F9" modified="2013-03-06" version="1">MRMFKVTACVPSQTRIRTQRELQNTYFTKLVPYENWFKEQQRIQKMGGSIVKVELATGRPGTNTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6N9</accession>
    <name>K9Z6N9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220522.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54799">
        <property type="protein sequence ID" value="AFZ54799"/>
        <property type="gene ID" value="Cyan10605_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2727"/>
    <dbReference type="eggNOG" id="ENOG5033DUB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175491_1_0_3"/>
    <dbReference type="OMA" id="RAESEMI"/>
    <dbReference type="OrthoDB" id="2068484at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="62" mass="7207" checksum="21491DFF65CC4F0D" modified="2013-03-06" version="1">MSEDTQKLRKMIENALADGVLSRAESEMIKREIYADKKVTPEEARLWQDLQRKISDGEVEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6R9</accession>
    <name>K9Z6R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219975.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2164"/>
    <dbReference type="EnsemblBacteria" id="AFZ54250">
        <property type="protein sequence ID" value="AFZ54250"/>
        <property type="gene ID" value="Cyan10605_2164"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2164"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2299"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094955_0_0_3"/>
    <dbReference type="OMA" id="DYNYGAR"/>
    <dbReference type="OrthoDB" id="1439632at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="2" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="218" mass="23555" checksum="FC3ABB5B1A70C5A7" modified="2013-03-06" version="1">MTQTLETSVQQLINAVNEADSAVKLLQAVQKLAAAQSPEAIPTLIQVLGFNNPGAAVAATEGLINLGEIAIAPLMKNLDDYNYGARAWALRVFAGIGDIRALDLLISAATTDFSLSVRRAATKGLGNIQLSSLPPEDIAPTQEKIFRTLCLTIQDGEWVVRYASIVALENLTQSLKAFNNNYLIPQIVEQLTLLSQKDDEIGVQTRAKLALTKIKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6W6</accession>
    <name>K9Z6W6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220211.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2405"/>
    <dbReference type="EnsemblBacteria" id="AFZ54487">
        <property type="protein sequence ID" value="AFZ54487"/>
        <property type="gene ID" value="Cyan10605_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2405"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813607_0_0_3"/>
    <dbReference type="OMA" id="KAWSQKG"/>
    <dbReference type="OrthoDB" id="1511263at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="347" mass="40670" checksum="D603152466E218DD" modified="2013-03-06" version="1">MTKEKNLFTISEEELTNALEISLERLDEIIDFFDSDPDDEWDLQENQDYIFLNKNKKIRKYSTNGALKIATYLDTHENRGIIAQIKEFITGHHRKIRNALAKKVILEELSDDDKIIQVNGRSMIQKQSLRRILATSGARLNKAIEDLRQSEKPLEANVDFTERESPKNKIKKRRNNQDSSENTVFELWFSGKGSVRIARELGENLKDKSRQKMCMAVSQQIEPVLQEKERKKLRFNKDIESAKNKAKKRDKNTCQITLVHKNDKKINAIAAHHLYSINKYPHLATSIDNLITIDERIHKEFHLTWMGGYDVECTVQDFIDFITERYPEQVTEELLDRLFHIQKTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y5</accession>
    <name>K9Z6Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220050.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54325">
        <property type="protein sequence ID" value="AFZ54325"/>
        <property type="gene ID" value="Cyan10605_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2239"/>
    <dbReference type="HOGENOM" id="CLU_173981_0_0_3"/>
    <dbReference type="OMA" id="WEIRQRA"/>
    <dbReference type="OrthoDB" id="2045566at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="10002" checksum="98288871DBD6A606" modified="2013-03-06" version="1">MITEQLLLIKWQSLDTEKKAKVLALIDDLIKDNEENDSEPLNYQPKTELGKKLWALRQKSLGSQPLLNNWDEVEKELADRRGGIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z705</accession>
    <name>K9Z705_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220695.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2914"/>
    <dbReference type="EnsemblBacteria" id="AFZ54976">
        <property type="protein sequence ID" value="AFZ54976"/>
        <property type="gene ID" value="Cyan10605_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2914"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_1_0_3"/>
    <dbReference type="OMA" id="RMYTHYE"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="86" mass="10370" checksum="CD603CBFFCD85F84" modified="2013-03-06" version="1">MWEVILSKKAQEDLEKLKNIGLFEKIKQLIAILRENPFLNPPSYEKLVGNLKGCYSRRINLKHRLVYRVIRETKTVEILRMWSHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z719</accession>
    <name>K9Z719_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ordered locus">Cyan10605_2873</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220661.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2873"/>
    <dbReference type="EnsemblBacteria" id="AFZ54939">
        <property type="protein sequence ID" value="AFZ54939"/>
        <property type="gene ID" value="Cyan10605_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2873"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3053"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_3"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="26370" checksum="23AC8B448743108C" modified="2013-03-06" version="1">MQIDVITLFPDFFSSPLSCGLLGKALNKGIASVNLVNPRDFTTDKHHQVDDEPYGGGVGMVLKPEPIFAAVESLPILESREVILLSPQGQTMDQPLLRELANFEQLVLICGHYEGIDERVQNIVTREVSLGDFVLTCGEIPALALINGVIRLLPGTVGKVESLYADSFEDGLLDYPHYTRPAVFRGWEVPPVLRSGNHKKIAQWRKEKQLEVTKKKRPDLMEKYYLELKNKNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z752</accession>
    <name>K9Z752_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2316"/>
    <dbReference type="EnsemblBacteria" id="AFZ54400">
        <property type="protein sequence ID" value="AFZ54400"/>
        <property type="gene ID" value="Cyan10605_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2316"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2460"/>
    <dbReference type="eggNOG" id="ENOG5032S1W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164107_0_0_3"/>
    <dbReference type="OMA" id="LTHENKP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13938" checksum="69E341A6586BF627" modified="2013-03-06" version="1">MASSKMLTTKKETVKIVPLPELTSEEKLFQKQRMRDVYLLLENLTLKEEATIKLIIDCLYDVGIINLINKKIQNRPLNKLAKIMASTPKPIFKILAWRWVRKNLSNKVANWLNNKVKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I2</accession>
    <name>K9Z7I2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220072.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2263"/>
    <dbReference type="EnsemblBacteria" id="AFZ54348">
        <property type="protein sequence ID" value="AFZ54348"/>
        <property type="gene ID" value="Cyan10605_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2263"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2403"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_0_3"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="21401" checksum="AC81CE8FA9B4F093" modified="2013-03-06" version="1">MSERTVITGKGLPLVGNDIDTDRIIPARFLRCVTFDGLGEQVFADDRKALNGQHPFDLPQYQNAKILVVNGNFGCGSSREHAPQAIARWGIDAIIGESFAEIFFGNCLAMGIPCVTSSAENIKSIQNLLQENPDIQMTLDLESLKVKCGHYSSAIKIDSGARNMLVTGKWDTCSLLIKNISQIKNTAEKLPYLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J4</accession>
    <name>K9Z7J4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220405.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2607"/>
    <dbReference type="EnsemblBacteria" id="AFZ54682">
        <property type="protein sequence ID" value="AFZ54682"/>
        <property type="gene ID" value="Cyan10605_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2607"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2770"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_3"/>
    <dbReference type="OMA" id="SMRHSFI"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="187" mass="21086" checksum="FE51DA8FC9056AE2" modified="2013-03-06" version="1" precursor="true">MFKHLLRNILVFSFIFIASFNFMPSAMALGGIQPSLNESAPDFTLPTNLGDGEVSLHDYRGKWVVLYFYPQDFTPGCTLEAKRFQQDLQKYHDLNAEIVGVSVDDVNSHQNFCDEEGLKFPLLADTEGKVSKAYGSWLSGRSLRHTYIINPEGILVAKFLGVRPAIHSQEVLSELNKLTSVQFKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L6</accession>
    <name>K9Z7L6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DevC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220112.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2304"/>
    <dbReference type="EnsemblBacteria" id="AFZ54388">
        <property type="protein sequence ID" value="AFZ54388"/>
        <property type="gene ID" value="Cyan10605_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2304"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2447"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_9_3"/>
    <dbReference type="OMA" id="YATLMAM"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005891">
        <property type="entry name" value="DevC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031773">
        <property type="entry name" value="DevC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01185">
        <property type="entry name" value="devC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="42386" checksum="1EA3E40E3A6A7753" modified="2013-03-06" version="1" precursor="true">MKTPLAWLQLSKEKIRLLIAIAGISFADILMFMQLGFKTALLNSAVRIHENIKGDIFLISPQSDALIGMKSFSSRRLYEALAVKEVESINPLYIGFTTWKNPLNQKTRQIMIMGFNPKEPIFNLSGVQKNLDKLKQPDQVLFDTDSRPEFGPIPELFQEGKTVKTEISNRQIEVAGLFTIGATFGADGNIITSDLNFLRIFAQRDKGLIDVGVINLEEDANTEAVIKTLKNKLSSGDVLVLSRDEFVNYERSYWENTTAVGFVFTLGTVMGLIVGTVIVYQILYTDVADHLPEYATLKAMGYTNNYLLVLVFQQAIILACIGFLPGLGFSAFLYSVTAKATGLPIFLSKSLIISVFLLTLFMCGFSGAIAVNKLKSADPADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L8</accession>
    <name>K9Z7L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220303.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2499"/>
    <dbReference type="EnsemblBacteria" id="AFZ54580">
        <property type="protein sequence ID" value="AFZ54580"/>
        <property type="gene ID" value="Cyan10605_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2499"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102554_0_0_3"/>
    <dbReference type="OMA" id="IHIHWEL"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="26807" checksum="A923108BA73EE35B" modified="2013-03-06" version="1">MSSRNRINYETFGTSVIGPFHQQKNRLNEDAWGRINNNSGVGIVVSDGMGSKSNARMGAKMACLAVKQSLLAWVKAPSAFPSLLLRLIHIHWELNILPALKKDSVATCLFAVVIPNGQLIMAQLGDGIAILRENNGQLTILSEKNKTFGNQTTGLGVAKSTQEWSFFTVPNFPPNSAVLLATDGIADDLKSDTLGDFVQFILDDFGTLAPQKRWRSLTKELKNWPTPKHLDDKTLAVLWHRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M8</accession>
    <name>K9Z7M8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Photosystem II reaction center protein T</fullName>
            <shortName evidence="9">PSII-T</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psbT</name>
        <name evidence="11" type="ordered locus">Cyan10605_2319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Seems to play a role in the dimerization of PSII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PsbT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220127.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2319"/>
    <dbReference type="EnsemblBacteria" id="AFZ54403">
        <property type="protein sequence ID" value="AFZ54403"/>
        <property type="gene ID" value="Cyan10605_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2319"/>
    <dbReference type="HOGENOM" id="CLU_217078_1_0_3"/>
    <dbReference type="OrthoDB" id="2094719at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009539">
        <property type="term" value="C:photosystem II reaction center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00808">
        <property type="entry name" value="PSII_PsbT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001743">
        <property type="entry name" value="PSII_PsbT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037268">
        <property type="entry name" value="PSII_PsbT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01405">
        <property type="entry name" value="PsbT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161029">
        <property type="entry name" value="SSF161029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="31" mass="3527" checksum="2E424C3CE0F5E074" modified="2013-03-06" version="1" precursor="true">MESVAYILVLAMMIAVLFFAVAFREPPKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7P3</accession>
    <name>K9Z7P3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220142.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2334"/>
    <dbReference type="EnsemblBacteria" id="AFZ54418">
        <property type="protein sequence ID" value="AFZ54418"/>
        <property type="gene ID" value="Cyan10605_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2334"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_2_0_3"/>
    <dbReference type="OMA" id="DWQAIQE"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="9983" checksum="E5AFF429A7620830" modified="2013-03-06" version="1">MKIINISTARNNLFSLIEQVNQDHHPRIISSKKGDVVILSKEDWDSLQETLYLQSIPNLVSSIKTAEKDNEWVSEEEFLGVLNDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R5</accession>
    <name>K9Z7R5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220939.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55221">
        <property type="protein sequence ID" value="AFZ55221"/>
        <property type="gene ID" value="Cyan10605_3170"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3170"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3378"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_3"/>
    <dbReference type="OMA" id="DTMVAGN"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="214"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="432" mass="47490" checksum="CB8CFFF3EBEBB674" modified="2013-03-06" version="1">MQPENLLDLVKKQGIKNAEVYQVESYSRPICFSANRLKQIESSQVSGVALRLWRDNKPGLALAYGEFTADDLIAKALAVSDLNDPEEIFLNGTNNLIYSNDDGNSKRFVDQDKKIIKEGGDAIASILDLYPEAIVNLDVEWERETTTLINTQGLYCQQKDISQSASVGLELVREEDFLGIYDGEYSHGHIDLSRIIESVLRRLEWAEKNVAVKTGKFPVLFTPNAVVTLWDTVTEALNGKYILDKSSPWSESLGKVVISPCLTLKQQPDLKPYDCPFDDEGSMTQNLTLIEAGVLKNFYTDKKTASKLGISNTGNGFRTGLGAYPSPDLVNLVISEGNKSFPEIVKNMDHGIIVDQILGGGADISGDFSFNIDLGYLVHNGKIQGRIKDTMLAGNVYQCLQKVNAIASDIVWSGACYTPSIVVDNISVVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V1</accession>
    <name>K9Z7V1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220535.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54812">
        <property type="protein sequence ID" value="AFZ54812"/>
        <property type="gene ID" value="Cyan10605_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2740"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2907"/>
    <dbReference type="eggNOG" id="ENOG5033Y8Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060581_0_0_3"/>
    <dbReference type="OrthoDB" id="1651813at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="262" mass="31103" checksum="DD9BE19D098A275D" modified="2013-03-06" version="1">MIKSTVDNLFTSIFCHETNSASLIIKFLLVLETEKLIPLFNISTNENNQSPIDAVVTNRQNEILLVRDIIQETQEKPNLPTLFFGSNFSVNLAQGWRLGVVDNLKFNTFLIFTQEGFILENPEPYLSFLPHHRQEYYAQLSEKYSFIPWDYWQNITLKFAEDKPECTLILHHDKNHYLQINLSNNSNSEAEQIESQLPLIFCYFILKRFWRYVEEFRQKSFFIFNPHDFLYLDCDRLSYFITNVLKNIDITEEDLDQLIRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W1</accession>
    <name>K9Z7W1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ordered locus">Cyan10605_2401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220207.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2401"/>
    <dbReference type="EnsemblBacteria" id="AFZ54483">
        <property type="protein sequence ID" value="AFZ54483"/>
        <property type="gene ID" value="Cyan10605_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2401"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2547"/>
    <dbReference type="eggNOG" id="COG1054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038878_0_0_3"/>
    <dbReference type="OMA" id="CDTHTNC"/>
    <dbReference type="OrthoDB" id="684577at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="252" mass="28973" checksum="8E2D4CB9AD434766" modified="2013-03-06" version="1">MNLIFASFYRFLPLENLEDLQAEFLQWCQEGEIKGTILIAKEGINANIVGEKEPLKEVIEKIQKKLNCDEWEIKYSDVEIMPFARMKVKIKKEIITFGIPDADPNKQVGTYIKPKDWNNLISQPDVKLVDTRNEYEVQIGTFKGAENPHIDSFTELNKYIEEHLNPEKDQKVAMFCTGGIRCEKVTALMLSKGFKEVYHLQGGILKYLQEIPPEESLWEGECFVFDERVAVKHGLEKGSYKLCPETGEPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7X8</accession>
    <name>K9Z7X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Photosystem II CP43 reaction center protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PSII 43 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein CP-43</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">psbC</name>
        <name evidence="13" type="ordered locus">Cyan10605_3250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.</text>
    </comment>
    <comment type="cofactor">
        <text evidence="11">Binds multiple chlorophylls and provides some of the ligands for the Ca-4Mn-5O cluster of the oxygen-evolving complex. It may also provide a ligand for a Cl- that is required for oxygen evolution. PSII binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cellular thylakoid membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the PsbB/PsbC family. PsbC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221014.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3250"/>
    <dbReference type="EnsemblBacteria" id="AFZ55296">
        <property type="protein sequence ID" value="AFZ55296"/>
        <property type="gene ID" value="Cyan10605_3250"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3250"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3464"/>
    <dbReference type="eggNOG" id="ENOG502Z7VA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028310_1_1_3"/>
    <dbReference type="OMA" id="WKDKNKM"/>
    <dbReference type="OrthoDB" id="166907at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01496">
        <property type="entry name" value="PSII_PsbC_CP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005869">
        <property type="entry name" value="PSII_PsbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044900">
        <property type="entry name" value="PSII_PsbC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33180">
        <property type="entry name" value="PTHR33180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="SSF161077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01153">
        <property type="entry name" value="psbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="8 11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="458" mass="50023" checksum="CF0B8AF98C042B46" modified="2013-03-06" version="1" precursor="true">MVTLSNPIGGRDLESTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWAGAMTLFETAHFIPEKPMYEQGLILLPHIATLGWGVGPGGEVVDTFPFFVVGVLHIISSAVLGVGGLYHALRGPETLEEYSSFFGYDWKDKNQMTNIIGYHLILLGIGALLLVFKAMFFGGVYDTWAPGGGDVRIITNPTLNPAIIFGYLIKAPFGGEGWFISVNNMEDIIGGHIWVGLICISGGIWHILTKPFGWVRRAFIWSGEAYLSYSLGALSLMGFIASVMVWYNNTAYPSEFYGPTGAEASQAQALTYLIRDQRLGANVGSAQGPTGLGKYLMRSPTGEIIFGGETMRFWDFRGPWLEPLRGPNGLDLDKIRNDIQPWQVRRAAEYMTHAPLGSLNSVGGVITDVNSFNYVSPRAWLATSHFVLGFFFLVGHLWHAGRARAAAGGFEKGIERETEPVLAMPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z806</accession>
    <name>K9Z806_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220251.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2447"/>
    <dbReference type="EnsemblBacteria" id="AFZ54528">
        <property type="protein sequence ID" value="AFZ54528"/>
        <property type="gene ID" value="Cyan10605_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2447"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2592"/>
    <dbReference type="eggNOG" id="ENOG5031HP9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093094_1_1_3"/>
    <dbReference type="OMA" id="FMIDERR"/>
    <dbReference type="OrthoDB" id="2003497at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021374">
        <property type="entry name" value="DUF2996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36341">
        <property type="entry name" value="PTHR36341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11210">
        <property type="entry name" value="DUF2996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="141" mass="16132" checksum="4B0D8C39E3525830" modified="2013-03-06" version="1">MTEETKTTPTKPAKKAKPPALEDKPFEEFMSEHFTPSLEKALTEKGLSEVALEFKKAKIPITGYESSPECWQIIGDLGDRTFYLYFLEEDISGQKGFSCTAKGEKPSTLESFMIDERRVNLDLMVLYTLQRLNGQKWLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z846</accession>
    <name>K9Z846_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-N1-methyladenine dioxygenase</fullName>
            <ecNumber evidence="2">1.14.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.11.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220281.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2477"/>
    <dbReference type="EnsemblBacteria" id="AFZ54558">
        <property type="protein sequence ID" value="AFZ54558"/>
        <property type="gene ID" value="Cyan10605_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2477"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2626"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_5_2_3"/>
    <dbReference type="OMA" id="TQHHWQH"/>
    <dbReference type="OrthoDB" id="1391445at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="22663" checksum="614808899CD12CFA" modified="2013-03-06" version="1">MIIDLPHSEISYHKNFWSEKEATLLLEKLKSEIQWQQKTITLFGKTHLEPRLTAWYGDEGKIYTYSNSTMFPHKWNKTLITIKNRIENIIGIEFNSVLLNYYRHGKDSMGWHSDNEPELGKNPVIASASFGGERRFLLKPRDKNQSQRKEIILRHGSLLIMAGETQHYWLHQIPKTSKPVSERINLTFRWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z874</accession>
    <name>K9Z874_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220654.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2866"/>
    <dbReference type="EnsemblBacteria" id="AFZ54932">
        <property type="protein sequence ID" value="AFZ54932"/>
        <property type="gene ID" value="Cyan10605_2866"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2866"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3046"/>
    <dbReference type="eggNOG" id="ENOG502Z81T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061685_0_0_3"/>
    <dbReference type="OMA" id="KFCEYTG"/>
    <dbReference type="OrthoDB" id="955117at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="30320" checksum="8C7EBE152959F4D2" modified="2013-03-06" version="1">MNDLNTNTVEQSNIYSFLKTTKRVRVSDGKEISIFNGTSSANYILLLVLPQLGDFDSLEYAWWLNKYQDILHEKKIALRAIAIGNLKSGEKYCQYTGFNPENLFLDETAEIHQQLNLYQGLNWQFPTFNCSQNQWLNLILMCAGIGSKGTLKEVLRGYFGDKKAPSLLQENEIVNIKFLPPIKGSLFNKVGKNYQRPFELATIRLKNMIEVLTNWRTYVPNDNYLTQRGGTFLFNNQGKIIYQHRDEGILGFAENKSNPLAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B8</accession>
    <name>K9Z8B8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221112.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3352"/>
    <dbReference type="EnsemblBacteria" id="AFZ55394">
        <property type="protein sequence ID" value="AFZ55394"/>
        <property type="gene ID" value="Cyan10605_3352"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3352"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3570"/>
    <dbReference type="eggNOG" id="ENOG5031E25">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170157_0_0_3"/>
    <dbReference type="OMA" id="RGYLASC"/>
    <dbReference type="OrthoDB" id="1867947at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014943">
        <property type="entry name" value="DUF1815"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08844">
        <property type="entry name" value="DUF1815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="118" mass="13424" checksum="651A721AD6A990FA" modified="2013-03-06" version="1">MFIRLAQQYREFVKDLVLNLQALAIVLEKRGYIASCYTCGTQLNSASFMVSLGDNHLIRFLVSDYGITWTEMQDDRELMKLEGAEAISQLQELADLVKYQIKASESKIPTYDHSLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D1</accession>
    <name>K9Z8D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221169.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3409"/>
    <dbReference type="EnsemblBacteria" id="AFZ55451">
        <property type="protein sequence ID" value="AFZ55451"/>
        <property type="gene ID" value="Cyan10605_3409"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3409"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3632"/>
    <dbReference type="eggNOG" id="ENOG5031FXK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133138_0_0_3"/>
    <dbReference type="OMA" id="WRAVICE"/>
    <dbReference type="OrthoDB" id="1936622at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="129" mass="14640" checksum="2FEF0CDFB6318A4C" modified="2013-03-06" version="1">MQLTSQEISYYRDQLSDCEPAMKSLDMIEDAEGDLEDAATSIALAIGQTPDRVDWLDGWAKRCRVAICEVSFRSDLEDNYIENAVKYLLEKKICPPLLITPLLIYVVKNGIEQFCEPLSYKLGNDNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D3</accession>
    <name>K9Z8D3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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            <dbReference type="EMBL" id="AFZ54633.1"/>
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    </evidence>
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    </evidence>
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</entry>
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
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                <person name="Laurent T."/>
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                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <source>
            <dbReference type="EMBL" id="AFZ54992.1"/>
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        <source>
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    <sequence length="542" mass="59207" checksum="C0C4B7B3EBFD0A95" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Cai F."/>
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                <person name="Goodwin L."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
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            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221194.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3436"/>
    <dbReference type="EnsemblBacteria" id="AFZ55476">
        <property type="protein sequence ID" value="AFZ55476"/>
        <property type="gene ID" value="Cyan10605_3436"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3436"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3661"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_3_3"/>
    <dbReference type="OMA" id="CGWVHGR"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="294"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="500" mass="58040" checksum="19CA6DD349B82B68" modified="2013-03-06" version="1">MYIVQIASECAPVIKAGGLGDVVYGLSRDIERRNHTLEVILPMYDCLKYDKIWNLHIAYEHLNVPWYGGTIHTSVYCGWVDGLQCFFIQPHSNDNFFNRGCYYGNNDDYMRFTFFSKAALEFLLATGKRPDIIHCHDWQTGLVPVMLFEQYSWLGMGDVRVCFTIHNFKHQGVAGKDILWATRLNNEPHFFSYDRLRDNFNPFGLNLMKGGIVYSNHVNTVSPHHAWEARYTDVSYGLGHTLDVHQSKFNGILNGIDYKTWNPEEDTHVPHHFSIDDLSGKLKNKKALRDRLLLRDEKKPIVAFIGRLDQQKGVELVHHSIYYCLRNNAQFVLLGSPTGREINEHFWREKHNLNDSPDCHLELGFDEDLAHLIYAGADMIVVPSSFEPCGLTQMIGLRYGTVPVVRGVGGLVDTVFDKDYDQFHEEEERNGYVFYQNDRPALESALERAIGLWHHYPLEFQKLQKQGMKYDYSWKRSGQEYIDLYDKIRHKEEVVEDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G2</accession>
    <name>K9Z8G2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221162.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3402"/>
    <dbReference type="EnsemblBacteria" id="AFZ55444">
        <property type="protein sequence ID" value="AFZ55444"/>
        <property type="gene ID" value="Cyan10605_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3402"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3622"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_5_0_3"/>
    <dbReference type="OMA" id="HAIAYMT"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="373" mass="40769" checksum="344225D22A27E3B8" modified="2013-03-06" version="1">MYDCIVVGAGPAGATSAYHLAKKGYSVLILEKASLPRYKPCGGGVSPLIQSWFDFDLSPAISLKSHTVYCTWEQKDAIAVDLGNNPIWMVRRDVFDYFLVTQAVKQGATLKDTTKVRGVEFVSNGWIVKTENESFKGRYLIGADGAKGSMAKWLGFGKQKKSVVGALELEIPVQKVENKETYLEFGLVQHGYAWNFPKADGYSIGAGGFAKNRKAQSFHKIIENYTGLFNLNAKDGCEHGHPLALWNGVQKLHTENAVLAGESACVVDPFTAEGIRPSIYSGLKASEAVANALAGEANALAKYSEIMAQEWGKEMLWAQRLASIFYRFPRLSYQLGVKHPSGGKTMMKIFAGEKTYSQVAQKGIKLLTNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8H8</accession>
    <name>K9Z8H8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220612.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2823"/>
    <dbReference type="EnsemblBacteria" id="AFZ54890">
        <property type="protein sequence ID" value="AFZ54890"/>
        <property type="gene ID" value="Cyan10605_2823"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2823"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3000"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_2_3"/>
    <dbReference type="OMA" id="AAFQYWV"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="443" mass="49452" checksum="832B6E47DDCAC149" modified="2013-03-06" version="1" precursor="true">MFLSLFGSRLQSLFVYLSWFIAGLLLTFLVSCTTSVSNPSESIEFWTMQLQPQFTSYFQELNSSFEQENPPSKVEWIDVPWNAMESKILTAVSAKTAPDVVNLNPDFASQLASRNAWLNLDTQIPSEVKDKYLGKIWDGNSINLCSAENQCEKIIFGIPWYLTTTITVYNEDLLNQAGVSQPPQTFADLAVVAQQVKEKTGKYAFFVPFVANDSNEVLQSFVQMGVSLLDENGKATFNTPEGLKVFQYWVDLYQRDLLPPEILTQGHRHAIELYQAGELALLGTGAEFLKTIATNAPTIYEKSNVTSQITGDTGKKNVAVMNLVIPKDTDKSEEALKYALFVTNGENQLKFTQQANVLPSHKDAIASYISSLEKENSNDILIQGRKISAQQLEEAEVLIPPVKNIGQLKKIIYDNIQQAMLGEKTVEQAINDAANQWDNSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K2</accession>
    <name>K9Z8K2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220642.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2853"/>
    <dbReference type="EnsemblBacteria" id="AFZ54920">
        <property type="protein sequence ID" value="AFZ54920"/>
        <property type="gene ID" value="Cyan10605_2853"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2853"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3032"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476279_0_0_3"/>
    <dbReference type="OMA" id="PGQNYIP"/>
    <dbReference type="OrthoDB" id="514542at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938654" evidence="1">
        <location>
            <begin position="21"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="392"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="572" mass="63010" checksum="B079E0D164EBA350" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8L8</accession>
    <name>K9Z8L8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220791.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3012"/>
    <dbReference type="EnsemblBacteria" id="AFZ55072">
        <property type="protein sequence ID" value="AFZ55072"/>
        <property type="gene ID" value="Cyan10605_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3012"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170530_0_0_3"/>
    <dbReference type="OMA" id="DMCEVFF"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="12813" checksum="F72416CA358992B7" modified="2013-03-06" version="1">MEYISLKNLPNQSVSHNQSIKKKTILSKGKLPHITNFSQAIFAPQQIAYVHNHDDMWEVFYVEQGTGIIKINEREYILEKGVCVLVEPKENHEIINNSDDNLIINYFGVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U4</accession>
    <name>K9Z8U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heavy metal translocating P-type ATPase</fullName>
            <ecNumber evidence="7">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220861.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3086"/>
    <dbReference type="EnsemblBacteria" id="AFZ55142">
        <property type="protein sequence ID" value="AFZ55142"/>
        <property type="gene ID" value="Cyan10605_3086"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3086"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3288"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_3"/>
    <dbReference type="OMA" id="DTRMANY"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="739" mass="80674" checksum="9B51E6A7A1679B4B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8W2</accession>
    <name>K9Z8W2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220526.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2731"/>
    <dbReference type="EnsemblBacteria" id="AFZ54803">
        <property type="protein sequence ID" value="AFZ54803"/>
        <property type="gene ID" value="Cyan10605_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2731"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2897"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_0_3"/>
    <dbReference type="OMA" id="GPVFYVQ"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="41"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="240" mass="27966" checksum="8145E95A893CAA9B" modified="2013-03-06" version="1">MTANSQLVSVKVIQSLARRGLIRLSRQSNRDRIKFTREFYKRTFDIVFSASVLILFSPLYAILAILVALSSPGPIFYAQERVGKNYRHFKCIKFRTMVVNADQVLEKMLAECPEKRREFEENFKLKEDPRITWIGKFLRLTSLDEFPQFWNVLMGDMSVVGPRPLVPDELHKYGSKMERVLTVKPGITGLWQVSGRNDIPYPQRVLIDVYYVNHHNWLLDLWIIIKTIGVVLFPQNNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z906</accession>
    <name>K9Z906_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxysome shell protein CcmK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Carbon dioxide-concentrating mechanism protein CcmK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmK</name>
        <name evidence="6" type="ordered locus">Cyan10605_3136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer. Interacts with CcmN and CcmO in the carboxysome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Carboxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The tight homohexamer forms a small pore which is positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial microcompartments protein family. CcmK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220906.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3136"/>
    <dbReference type="EnsemblBacteria" id="AFZ55187">
        <property type="protein sequence ID" value="AFZ55187"/>
        <property type="gene ID" value="Cyan10605_3136"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3136"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3342"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_0_3"/>
    <dbReference type="OMA" id="ITHYIVP"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00854">
        <property type="entry name" value="CcmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046380">
        <property type="entry name" value="CcmK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="4" id="KW-1282">Carboxysome</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="5">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11336" checksum="F4D926AA0B00FF1C" modified="2013-03-06" version="1">MPEAVGVIETLGFPSILATADAVVKAARVTIVYFDKAEKGDFIIAFRGPVSEVKRAMEEGIREGANVFGGVIQSHYIVPNPPPNVVDVLPIHYTEASEPYRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z980</accession>
    <name>K9Z980_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3236"/>
    <dbReference type="EnsemblBacteria" id="AFZ55282">
        <property type="protein sequence ID" value="AFZ55282"/>
        <property type="gene ID" value="Cyan10605_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3236"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3450"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_3"/>
    <dbReference type="OMA" id="AKITQPF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="368" mass="41566" checksum="EA6FC5FB8E522442" modified="2013-03-06" version="1">MNNILTTTILIVEDELIAAESLALDLKKLGYHISAVVNSGEKAISQVEKSPPDLILMDIMLKGKMDGISAAQQIYHQWKIPIIYLSAYADTDTLQRAKATPVYGYLVKPYKIADISTTISMALAKYREDKHTEEELCAEKKINELKSRALATASHDLRTPLTNILGYTELIRDYGDRISPDKKERYFNFIKSAVGKMKDSLEDLLLISRAEEGKVTLYPQNFNLVEYLEILVEEYKNLSDEHQIKLCTNDNQYDVCLDQKILNHILHNLLSNAIKYSPQGGEVRLKLDKNEEEIILEIEDDGIGIPEDYQDKLFHLFERGNNVGNIKGNGLGLSIVKKAVELCQGNIFVESEENKGSKFTVVLPRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9F5</accession>
    <name>K9Z9F5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">Cyan10605_2961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2961"/>
    <dbReference type="EnsemblBacteria" id="AFZ55023">
        <property type="protein sequence ID" value="AFZ55023"/>
        <property type="gene ID" value="Cyan10605_2961"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2961"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3151"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_3"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ55023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="568" mass="59848" checksum="CE4D2DC0A56AFADB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9I8</accession>
    <name>K9Z9I8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_3191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220958.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3191"/>
    <dbReference type="EnsemblBacteria" id="AFZ55240">
        <property type="protein sequence ID" value="AFZ55240"/>
        <property type="gene ID" value="Cyan10605_3191"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3191"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3401"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298045_0_0_3"/>
    <dbReference type="OMA" id="VYLETCY"/>
    <dbReference type="OrthoDB" id="36006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="203"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="616"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="990" mass="115837" checksum="DB0B7D837A4D235E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9X7</accession>
    <name>K9Z9X7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221108.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3348"/>
    <dbReference type="EnsemblBacteria" id="AFZ55390">
        <property type="protein sequence ID" value="AFZ55390"/>
        <property type="gene ID" value="Cyan10605_3348"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3348"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3566"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067698_2_0_3"/>
    <dbReference type="OMA" id="NPEWGVR"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="PTHR20974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="206" mass="23377" checksum="A6A4F6CC07A54FCB" modified="2013-03-06" version="1">MKKHAPATINNRKPILEVLKSIIANNDTGNILEVASGTGEHSIFFAPHFPQQKWIPSDQNPESIASIKAWREEYPCANLQSPLMIDVMESDWYLSLKTEKISTIICINMIHIAPWEACLGLMEGAGDLLPLNGILYLYGAYKLNNQHTAPSNEEFDYYLRSQNPAWGVRNLEDVEKVANKYQLELEQKIAMPANNFSLIFRKTNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAC4</accession>
    <name>K9ZAC4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221041.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3277"/>
    <dbReference type="EnsemblBacteria" id="AFZ55323">
        <property type="protein sequence ID" value="AFZ55323"/>
        <property type="gene ID" value="Cyan10605_3277"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3277"/>
    <dbReference type="HOGENOM" id="CLU_1515449_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938725" evidence="1">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="177" mass="18137" checksum="BAA17F89D068B9AE" modified="2013-03-06" version="1" precursor="true">MNIKNYSAKLAVASVALVSSVITFAPKAIAQTATFSFTREIETGCVFIGGTDAGSGSVTTESELTEDLVNNTLSGNNTDISVECNFDGGTLQITGVTEGTNEVTLNSDNNLTATLGLNNNASVPSLTANRGGSSTTSELDAGTTDMTLQLLADFGAGSQTLQAGSYSYEVQVTLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAJ1</accession>
    <name>K9ZAJ1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221131.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3371"/>
    <dbReference type="EnsemblBacteria" id="AFZ55413">
        <property type="protein sequence ID" value="AFZ55413"/>
        <property type="gene ID" value="Cyan10605_3371"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3371"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087351_0_3_3"/>
    <dbReference type="OMA" id="RIALFYC"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="162" mass="18915" checksum="BA2F1AABAFE8C338" modified="2013-03-06" version="1">MEELSFSMATERDFDTLQQIYRYTVQKLAPSLYSPAQVEAWSAAPNNFNCFQYFIFDPDTYLLLIKQQIVGFCGLRKNGHIASLYIHPDYTRQGYGTKLLNYVLNIGVNRQIKRFFTEASFFSYPVFTRCGFTVIEMETVNYGDVAFDRYKMEKIIPYTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZD2</accession>
    <name>K9YZD2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ordered locus">Cyan10605_0105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217996.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0105"/>
    <dbReference type="EnsemblBacteria" id="AFZ52264">
        <property type="protein sequence ID" value="AFZ52264"/>
        <property type="gene ID" value="Cyan10605_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0105"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.108"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_3"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="172" mass="18845" checksum="2B7341E2B7CD9100" modified="2013-03-06" version="1">MDLKALIRDIPDFPQPGVIFRDITTLLKEPKGLKYVIDSLALECEKLENTPDYIIGIESRGFIFAPALAYHLDAGFVPVRKKGKLPADVHSIEYQLEYGTDTLEIHQDAIPSGSKVMIVDDVIATGGTAKATSDLVQQIGSELVAFGFIVELTGLEGRKKLPDLPCISLVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZI5</accession>
    <name>K9YZI5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218093.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0205"/>
    <dbReference type="EnsemblBacteria" id="AFZ52361">
        <property type="protein sequence ID" value="AFZ52361"/>
        <property type="gene ID" value="Cyan10605_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0205"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.215"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028023_0_0_3"/>
    <dbReference type="OMA" id="NWTWGND"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938975" evidence="3">
        <location>
            <begin position="29"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="681" mass="76686" checksum="C038F8A9ED97D0DE" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZU3</accession>
    <name>K9YZU3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218203.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0323"/>
    <dbReference type="EnsemblBacteria" id="AFZ52471">
        <property type="protein sequence ID" value="AFZ52471"/>
        <property type="gene ID" value="Cyan10605_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0323"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.337"/>
    <dbReference type="eggNOG" id="ENOG502Z9RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178660_0_0_3"/>
    <dbReference type="OMA" id="QRVDWEW"/>
    <dbReference type="OrthoDB" id="1256705at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="27790" checksum="171FD7B85CEAFB19" modified="2013-03-06" version="1">MELKREFFPLVRKTVMPRPYYTEETDVLGQKGTALAVNAAIYGDNWYLDREAGLIEIYGAGAAICFRNILPRKNKYEKEGLYLRLKLAYRTTENANVNIRTFSGRHITIPNSLEGAMYDDSETYWYVTDDLTLNINSIYTDEKMWIQRVDWEWVSKEVIYEDEAVEERKLFIPRNPKDIEKLYVPQKVNPTTIKEFLVKKIQNDDYFAKRCLSMLCEDKLMAKDMVELFKETGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z028</accession>
    <name>K9Z028_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218292.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0417"/>
    <dbReference type="EnsemblBacteria" id="AFZ52561">
        <property type="protein sequence ID" value="AFZ52561"/>
        <property type="gene ID" value="Cyan10605_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0417"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_2_3"/>
    <dbReference type="OMA" id="MVIVANS"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="110" mass="12442" checksum="2EDD62C4DB2670FF" modified="2013-03-06" version="1">MINISKRAIAELKRIQKNQYPDCNHIRVGINQGGCLNYAYNIEFAQEINEADLTFNHDSGMVIVANSEIYSRLQNLTIDYLEDLMGGAFQFKNPNIAHHCSCGLSFDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0A6</accession>
    <name>K9Z0A6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (NADH) large subunit</fullName>
            <ecNumber evidence="16">1.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_0489</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="16"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218362.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0489"/>
    <dbReference type="EnsemblBacteria" id="AFZ52631">
        <property type="protein sequence ID" value="AFZ52631"/>
        <property type="gene ID" value="Cyan10605_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0489"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.518"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_3"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1552" mass="170908" checksum="A9FA5387C2F33B17" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B2</accession>
    <name>K9Z0B2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Photosystem I P700 chlorophyll a apoprotein A1</fullName>
            <ecNumber evidence="20">1.97.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">PsaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">psaA</name>
        <name evidence="23" type="ordered locus">Cyan10605_0462</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>The structure of photosystem I from a high-light-tolerant cyanobacteria.</title>
            <authorList>
                <person name="Dobson Z."/>
                <person name="Ahad S."/>
                <person name="Vanlandingham J."/>
                <person name="Toporik H."/>
                <person name="Vaughn N."/>
                <person name="Vaughn M."/>
                <person name="Williams D."/>
                <person name="Reppert M."/>
                <person name="Fromme P."/>
                <person name="Mazor Y."/>
            </authorList>
            <dbReference type="PubMed" id="34435952"/>
            <dbReference type="DOI" id="10.7554/elife.67518"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 10-750</scope>
    </reference>
    <comment type="function">
        <text evidence="2 20">PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.</text>
    </comment>
    <comment type="function">
        <text evidence="21">PsaA and psaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:30407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10039"/>
            <dbReference type="Rhea" id="RHEA-COMP:10040"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.97.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="20">PSI electron transfer chain: 5 chlorophyll a, 1 chlorophyll a', 2 phylloquinones and 3 4Fe-4S clusters. PSI core antenna: 90 chlorophyll a, 22 carotenoids, 3 phospholipids and 1 galactolipid. P700 is a chlorophyll a/chlorophyll a' dimer, A0 is one or more chlorophyll a, A1 is one or both phylloquinones and FX is a shared 4Fe-4S iron-sulfur center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20 21">Cellular thylakoid membrane</location>
            <topology evidence="20 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the PsaA/PsaB family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.12" evidence="20"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218335.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VPV">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="1/A/a=10-750"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z0B2"/>
    <dbReference type="STRING" id="755178.Cyan10605_0462"/>
    <dbReference type="EnsemblBacteria" id="AFZ52604">
        <property type="protein sequence ID" value="AFZ52604"/>
        <property type="gene ID" value="Cyan10605_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0462"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.488"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016126_1_0_3"/>
    <dbReference type="OMA" id="TWAFFHA"/>
    <dbReference type="OrthoDB" id="32023at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00458">
        <property type="entry name" value="PSI_PsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006243">
        <property type="entry name" value="PSI_PsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001280">
        <property type="entry name" value="PSI_PsaA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020586">
        <property type="entry name" value="PSI_PsaA/B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036408">
        <property type="entry name" value="PSI_PsaA/B_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30128:SF60">
        <property type="entry name" value="PTHR30128:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00223">
        <property type="entry name" value="PsaA_PsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002905">
        <property type="entry name" value="PSI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00257">
        <property type="entry name" value="PHOTSYSPSAAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81558">
        <property type="entry name" value="SSF81558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01335">
        <property type="entry name" value="psaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00419">
        <property type="entry name" value="PHOTOSYSTEM_I_PSAAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="25" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 20 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20 21" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="15 20 21" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13 20 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="17 20 21" id="KW-0408">Iron</keyword>
    <keyword evidence="18 20 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 20 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 20 21" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11 20 21" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 20 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>chlorophyll a'</name>
            <dbReference type="ChEBI" id="CHEBI:189419"/>
            <label>A1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>A3</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>A3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>phylloquinone</name>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <label>A</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AFZ52604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="6VPV"/>
        </source>
    </evidence>
    <sequence length="750" mass="82600" checksum="3B246BDDFB9838BE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0U5</accession>
    <name>K9Z0U5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0684"/>
    <dbReference type="EnsemblBacteria" id="AFZ52821">
        <property type="protein sequence ID" value="AFZ52821"/>
        <property type="gene ID" value="Cyan10605_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0684"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.719"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_3"/>
    <dbReference type="OMA" id="GEGEKMP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="642" mass="72245" checksum="4F95DA8E607C9B42" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z107</accession>
    <name>K9Z107_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0753"/>
    <dbReference type="EnsemblBacteria" id="AFZ52886">
        <property type="protein sequence ID" value="AFZ52886"/>
        <property type="gene ID" value="Cyan10605_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0753"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.791"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_0_1_3"/>
    <dbReference type="OMA" id="WIDFATC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="89" mass="9688" checksum="339B1C8E7629E524" modified="2013-03-06" version="1">MFSTEKDSQSGEKTLPHTIVTDVCEGIADCVSACPVACIHEGPSKNIKGTDWYWIDFDTCIDCGICLQVCPVEGAILAEERPELQKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z164</accession>
    <name>K9Z164_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="11" type="synonym">atpI</name>
        <name evidence="13" type="ordered locus">Cyan10605_0771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218635.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0771"/>
    <dbReference type="EnsemblBacteria" id="AFZ52904">
        <property type="protein sequence ID" value="AFZ52904"/>
        <property type="gene ID" value="Cyan10605_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0771"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.812"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_4_3"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="28056" checksum="E438A624DD0DB6C5" modified="2013-03-06" version="1">MDFANTLNLFHQFNLAAIEVGEHFYWEIGKYKVHGQVFMVSWFVIGVLLIASIAATRNIQRIPSGFQNFMEYVLDFLRGLAKDQIGEKEYRPWVPFIGTLFLFIFVSNWSGALIPWKLIEIPEGELSAPTVDINTTVAFALLTSLAYFYAGISKKGLGYFADYAQPSPIMVPFRAIEDFTRPLSLSFRLFGNILADELAVGVLVLLVPLIIPLPLMILGLFTSAIQALIFATLAASYIGEAMEGHGEEHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1B1</accession>
    <name>K9Z1B1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52355">
        <property type="protein sequence ID" value="AFZ52355"/>
        <property type="gene ID" value="Cyan10605_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0199"/>
    <dbReference type="HOGENOM" id="CLU_3327047_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="38" mass="4842" checksum="CEDF61674DAD4B69" modified="2013-03-06" version="1">METLRYILQYRFFHKQQIIKLELGYREQDELDIRLPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1C9</accession>
    <name>K9Z1C9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polynucleotide adenylyltransferase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217895.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0002"/>
    <dbReference type="EnsemblBacteria" id="AFZ52163">
        <property type="protein sequence ID" value="AFZ52163"/>
        <property type="gene ID" value="Cyan10605_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0002"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_0_3"/>
    <dbReference type="OMA" id="FDEAIYK"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="254"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="404" mass="46465" checksum="C74D225CF26A0BCB" modified="2013-03-06" version="1">MILHNFLKQNLPFDVNLLPDNCYLVGGAVRDILLKRSRSYLDLDFVLPHKPIETAKIIAREYQAGFVVLDPVRYIARVVFPHATIDFAGQEGDSIYQDLARRDYTINAIAFHCREGVIIDPFQGEIDIKKGILKMISRDNLADDPLRLMRGYRQASQLDFTIESFTRATIKDLKELLKNVAMERVNQELAYLFETKKGSYWLKEAFKDGLLDLCFPSADEKMVNLLANIDESAQFLSSKYRSNFPDNYSWYKEAKLACLTNQNPSIAETELINLKYSRQEIKSVLTILQFTNNLTEIDFQKNKRKQYFFFQSVGDYFPNLAVFALAHNVSKDLILQLMELYQNPEDAIAHPQPLLSGKDIMKYLNIAPSPLIGKILTEIQIAYIEGKINNKETAIDFIKNNFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1E1</accession>
    <name>K9Z1E1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0238"/>
    <dbReference type="EnsemblBacteria" id="AFZ52390">
        <property type="protein sequence ID" value="AFZ52390"/>
        <property type="gene ID" value="Cyan10605_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0238"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.247"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_5_3"/>
    <dbReference type="OMA" id="PIFYNAC"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="379" mass="43877" checksum="6037E23D119C80DD" modified="2013-03-06" version="1">MKVLFDCTSVRDRISGIGYYTYSLMKALQKGNFPDLELNFCRQPSMKQWLKHQQDLPDVLKQFPSIQFLPFPVTVSDFLGKSAGYFTNNIGHFDIIHGTDHYVYPFKEGKKIMNIHDLTFLKYPQFCTNIVKQYTRRIKKCLPWTDLIITFAESTKKDIIDYLGVKEEKIFITSEASRYDFNYLKTINIDLIKSKTNYDFSQKYLLFVSTIEPRKNIISLIKAFNICKEKYHLHHHLILIGNKGWQYEPIFAEIENSPFSDQIHHLGYLTDAQLAIFYAHADMFIYPSFYEGFGLPILEAMTLGTPVITSSVSSMPEVGGDAAIYVNPHDVDALANRIYQLGLDPILRQSLIEKGKNRAKLYSWQRVAQETLKAYSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G1</accession>
    <name>K9Z1G1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolysaccharide synthesis ExoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218147.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0265"/>
    <dbReference type="EnsemblBacteria" id="AFZ52415">
        <property type="protein sequence ID" value="AFZ52415"/>
        <property type="gene ID" value="Cyan10605_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0265"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.275"/>
    <dbReference type="eggNOG" id="COG3932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093444_0_1_3"/>
    <dbReference type="OMA" id="FGLKPWL"/>
    <dbReference type="OrthoDB" id="2077544at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010331">
        <property type="entry name" value="ExoD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41795">
        <property type="entry name" value="PTHR41795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06055">
        <property type="entry name" value="ExoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033239">
        <property type="entry name" value="ExoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="207" mass="22784" checksum="EBB1A4F9302A8A66" modified="2013-03-06" version="1">MSKLSQELNDYFFVQEREEKITLEEILSLAGERIFGFLLVILSLPSALPIPAPGYSIPFGILIFLLAIQLVIGHKTPWLPDKMLKGAMKTSTARKFVQMGLPWLKRIENLTKPRLTYICTSFSGRIVIGIAIALMAISMMIPIPGTNTAPAMGIFVTAFGMQEDDGFIVLAGLSLCLIAGVVSASIIFATIWGGLSIIDWIEQYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G4</accession>
    <name>K9Z1G4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Cyan10605_0921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218782.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0921"/>
    <dbReference type="EnsemblBacteria" id="AFZ53051">
        <property type="protein sequence ID" value="AFZ53051"/>
        <property type="gene ID" value="Cyan10605_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0921"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="YNACATG"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="13">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="14">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="406" mass="46091" checksum="9FEDA9FB7F0114B9" modified="2013-03-06" version="1">MHRAIKVRIYPNKTQAKKLSQVMGCCRWWYNYALNLCVDTYKATGKTLKQVALNKYLPKLKKEEDTAWLGDCYSQCLQSTTLNLTKAFKNFFEGRAKYPRYKSYQGRQSCQYPQNVSIVDGCLKIPQLGLVKAVIHRIFEGEIKTVTVSKTPTGKYYASILFDTKQTFPEVTITGKVCGIDLGIKDFAIVHDGRKTSKYANPRHIKKHEKNLARKQQKLARKQKGSKNREKARKLVAKVHERISNARQDFLHKLSRKIVNNNQVVVIEQLNIKGMVRNHNLAKAISDVGWGTLINFLDYKLKQKGGLLVEIDRWFPSSKTCSHCHYQMSEMPLEIREWTCPSCGSHHDRDENASKNIRAEGIRKIQTDGTAVSASGGSVRPKGGRKSVLRHEPVKDEAPDSAIAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1H2</accession>
    <name>K9Z1H2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_0438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218313.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0438"/>
    <dbReference type="EnsemblBacteria" id="AFZ52582">
        <property type="protein sequence ID" value="AFZ52582"/>
        <property type="gene ID" value="Cyan10605_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0438"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.463"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250009_0_0_3"/>
    <dbReference type="OMA" id="TCEVICA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="8">
        <location>
            <begin position="327"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="518"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="599"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="721"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="774"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="847"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ52582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1474" mass="168675" checksum="28DC611E543D86A9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1K3</accession>
    <name>K9Z1K3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218775.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0914"/>
    <dbReference type="EnsemblBacteria" id="AFZ53044">
        <property type="protein sequence ID" value="AFZ53044"/>
        <property type="gene ID" value="Cyan10605_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0914"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.961"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923532_0_0_3"/>
    <dbReference type="OMA" id="GWGLSHY"/>
    <dbReference type="OrthoDB" id="906284at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="304" mass="34243" checksum="B8DAD7FCA6B35F2B" modified="2013-03-06" version="1">MSEISNKISGFTLNHVDLESKTQRLLTSALKRANICTSCQPQSLFWDANYFGLNQVKYFCSATPQQQQQILQFANKDLLEEIYWVEQAGVGYMAKMVILAQTHEERLLYSLFSADEATHLATITPFLKEVPVFSGDTFLSYMAKAIESDDKLLLMVLVQVVLEGWGMGHYRSLAKYCLNPHLGEVLQGFLDAEARHHALGVTLVKNSTDYCQESLGNIYSALTYFLHIVQVGPQRLLINIERVLGYLSANDKVEILTELETEKHSSKKLDLLRSLLVGTVPDSIIESLEKQGSFHPYSPSQCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Q2</accession>
    <name>K9Z1Q2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CP12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218820.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0959"/>
    <dbReference type="EnsemblBacteria" id="AFZ53089">
        <property type="protein sequence ID" value="AFZ53089"/>
        <property type="gene ID" value="Cyan10605_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0959"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1012"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137076_2_1_3"/>
    <dbReference type="OMA" id="DAAECRI"/>
    <dbReference type="OrthoDB" id="2023682at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039314">
        <property type="entry name" value="CP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003823">
        <property type="entry name" value="CP12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33921">
        <property type="entry name" value="PTHR33921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01093">
        <property type="entry name" value="CP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP12" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="74" mass="8343" checksum="7BF365F6681AF12A" modified="2013-03-06" version="1">MSNIQDQIQEELKHAREVCDSPDSNSGECAAAWDAVEELQAEASHQKTKEPKKNSLEQYCSENPEAAECRLYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R1</accession>
    <name>K9Z1R1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ordered locus">Cyan10605_0141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218030.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0141"/>
    <dbReference type="EnsemblBacteria" id="AFZ52298">
        <property type="protein sequence ID" value="AFZ52298"/>
        <property type="gene ID" value="Cyan10605_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0141"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.146"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_3"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="435" mass="46532" checksum="BD8A061E73FD8B6E" modified="2013-03-06" version="1">MVNTVSFKTTKSDEIFAAAQKLMPGGVNSPVRAFKSVGGQPIVFDRVKGAYIWDVDENKYIDYVGTWGPAICGHAHPEVIKSLSEALEKGTSFGAPCYLENILAEMVIDAVPSIEMVRFVNSGTEACISVLRLMRAYTGRNKIIKFEGCYHGHGDMFLVKAGSGVATLGLPDSPGVPKSVTSDTLTAPYNDLEAVKKLFADHPDEIAGVILEPVVGNSGFIVPDAGFLEGLRLITEQNGALLVFDEVMTGFRISYGGAQAKFGITPDLTTLGKVIGGGLPVGAYGGKKEIMAMVAPSGPMYQAGTLSGNPLAMTAGIKTLELLQKPGTYEYLEEITHKLISGLLTIAKNTGHKVTGGNISGMFGMFFTGEEVHNYDDAKKADTSKFARFHRGMLERGVYLAPSQFEAGFTSIAHTEEDINQTLAMAEEVLKEIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R2</accession>
    <name>K9Z1R2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="8" type="synonym">rpl22</name>
        <name evidence="12" type="ordered locus">Cyan10605_0520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0520"/>
    <dbReference type="EnsemblBacteria" id="AFZ52662">
        <property type="protein sequence ID" value="AFZ52662"/>
        <property type="gene ID" value="Cyan10605_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0520"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.550"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_3"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="124" mass="14069" checksum="892EA34EB37D5405" modified="2013-03-06" version="1">MAKSKTNIEVDTSQEVKAIARYIRMSPFKVRRVLNQIRGRSYREALILLEFMPYRACEPIVKVLRSAVANAEHNQGLDPNDLVISQAFADGGPTLKRYRPRAQGRAYQIRKRTCHITVAVAPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1T7</accession>
    <name>K9Z1T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218065.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0176"/>
    <dbReference type="EnsemblBacteria" id="AFZ52333">
        <property type="protein sequence ID" value="AFZ52333"/>
        <property type="gene ID" value="Cyan10605_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0176"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.185"/>
    <dbReference type="eggNOG" id="COG0435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_2_3"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="780709at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="177"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="319" mass="37101" checksum="C7634F561063A351" modified="2013-03-06" version="1">MTDLKNKSTSLPQSWLIITGKWVWHTLWRIMMSQLAPTEKQGNYQRPSSQFRHQVKSEVNYLYQPEKGRYRLYVGMSCPWAHRTLIVRSLKGLEDVIDIEILIPSVNQGGWIMETESENCRTLAQLYRLSQSSYRGRNTVPVLWDKQTKTIVNNESADIILLLNSEFNQYAKNPNLNLYPSSLVRQIDQWNEKIYHNVNNGVYRCGFAQTQEAYELACRSLFDTLAQIEIHLASNRYLCGDSFTLADVRLFTTLIRFDMVYYPLFKCSLNAIASYPHLSRYVEDINNLPNIKNTYDLNAIKQDYYGNLFPLNPSGIIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z214</accession>
    <name>K9Z214_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H-quinone oxidoreductase subunit 1</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(P)H dehydrogenase I subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndhA</name>
        <name evidence="7" type="ordered locus">Cyan10605_0623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of at least 11 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218493.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0623"/>
    <dbReference type="EnsemblBacteria" id="AFZ52762">
        <property type="protein sequence ID" value="AFZ52762"/>
        <property type="gene ID" value="Cyan10605_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0623"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.657"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_3"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="372" mass="40302" checksum="12CB4A6168916632" modified="2013-03-06" version="1">MSAGIDLQGSFITSLTDLGLPPELAKTLWIPLPLGLMIIGATVGVLVSVWLERKISAAAQQRIGPEYAGPLGVLQPVADGIKLVFKEDIIPSKADGLLFTLGPAIVVIPVFLSYLIVPFGQNLVITDLNMGIFIWISLSSIAPIGLLMSGYASNNKYSLLGGLRAAAQSISYEIPLALAVLAIAMMSNSLSTIDIVEQQSGYGILGWNIWRQPVGFLIFWIAALAECERLPFDLPEAEEELVAGYQTEYAGMKFGLFYVGSYVNLVLSALVFAVLYLGGWEFPIPLNNLASWLGVSENTPWLQVITASLGITMMVLKAYFLVFIAILLRWTVPRVRIDQLLDLGWKFLLPVALVNLLLTAALKLAFPVAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z222</accession>
    <name>K9Z222_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase alpha (Molybdopterin) subunit</fullName>
            <ecNumber evidence="4">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218503.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0633"/>
    <dbReference type="EnsemblBacteria" id="AFZ52772">
        <property type="protein sequence ID" value="AFZ52772"/>
        <property type="gene ID" value="Cyan10605_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0633"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.669"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_16_1_3"/>
    <dbReference type="OMA" id="DCSDLCH"/>
    <dbReference type="OrthoDB" id="50471at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="2">
        <location>
            <begin position="108"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="3">
        <location>
            <begin position="638"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="748" mass="82167" checksum="8216D4B3FE6053FB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C3</accession>
    <name>K9Z2C3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6Y C5,15-methyltransferase (Decarboxylating)</fullName>
            <ecNumber evidence="8">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218269.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0394"/>
    <dbReference type="EnsemblBacteria" id="AFZ52538">
        <property type="protein sequence ID" value="AFZ52538"/>
        <property type="gene ID" value="Cyan10605_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0394"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.417"/>
    <dbReference type="eggNOG" id="COG2241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031955_1_2_3"/>
    <dbReference type="OMA" id="MPVTQWS"/>
    <dbReference type="OrthoDB" id="1706318at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="7">
        <location>
            <begin position="261"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="414" mass="46662" checksum="90F7254FDEA64464" modified="2013-03-06" version="1">MTIKVVGIGLEGKKSLNDQVLEIVCSANILVGGDRHLSYFPEHKGERIKIGDLNQVIFEIKEKKKEEINIVILASGDPLFFGIGRILLANFAQEELEFYPNLSCVQLAFNKLKTSWQDCKVISLHGRDIELLIKELKKGSEKIALLTDNNNNPLVIWRLYQQIKIGEDYDIWLCESLGDKSQEKLTKINSEKDINLDNISHLNIVIFLKQKIEDNAININQLPIIGIPDNYFKTFPDRPSLITKNEIRLLILGKLALQEKQVIWDVGAGTGSVSIEMARIAKNSQIYAIEKKAIAISLIRENCQKFMVNNINIIHNSAEKVMATLPSPDRVFIGGSSGNLKLLLNIIKDKINPEGKIVIALATIENLGIAVEWFKENKWDYEIINSQINKSLSIGKMTRFNPLNPVNIITAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U8</accession>
    <name>K9Z2U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP-like extracellular</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0922"/>
    <dbReference type="EnsemblBacteria" id="AFZ53052">
        <property type="protein sequence ID" value="AFZ53052"/>
        <property type="gene ID" value="Cyan10605_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0922"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584897_0_0_3"/>
    <dbReference type="OrthoDB" id="749338at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="467" mass="52324" checksum="31FE2455F33B84D8" modified="2013-03-06" version="1">MENREPSAIDQLMLELINVARANPQQEADRLLNGQLNEGVSPNSLITLAPKQPLAFNYYLIDSAYNHSSWMLANDIFSHTGIDNTTSQQRMARAGYEFTAPWGSGENIAWKGTTGDLDFNEFVIDNYTNLFVDENYPNRGHRVSLMRDEFQEVGIASLEGIFSLNGRDYNAVMTTQNFAYSKKDGAFLTGVIYTDEIIDDNFYSLGEGIANVRILAENLDTGDRIETVNFSTGGYSLFLPSGTYEISFIGNLDQDPADDIVKSKVTISDVNIKLDLATDDPNLATGILASPTENNETENPVEENNVGNESETNQSTDDLSMFMDTPIYRLQNLDRPGTYLYAGEEEVRNIGRNYPQFQLEGLAFNVSETADEDLLTIYRFRNQNIAGTYLFVGEEEKNNILDNYPNFILEGTAFHVIPPSSNQGNSIYRFQNSDLLGTYLFVGETEKNTILQDYSNFILEGTAFNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2U9</accession>
    <name>K9Z2U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219265.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1425"/>
    <dbReference type="EnsemblBacteria" id="AFZ53536">
        <property type="protein sequence ID" value="AFZ53536"/>
        <property type="gene ID" value="Cyan10605_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1425"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_3"/>
    <dbReference type="OMA" id="SSKIEHM"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="250" mass="28930" checksum="96F20E85AC201034" modified="2013-03-06" version="1">MSISPILQAKNISLLTKIHQNHLLDNISFDVNEGEKIALIGGNGAGKSTLLKVLNHLCTSSKGDLYFRGKLVHHWDVLKFRRQVMLIPQESKLLGMNVKSALSYPLQLQSLSEKEIQTRLIYCLQEFNFIESWLEKRENELSLGQKQLVAIARAIIMQPSVLLLDEPTSALDKGNAHWLREKLQVWNEEKKMTIIVINHDLEWVKNFAQRVIWLDKGRIKKDLSAKLVDWEMIEKHLLILNQEMNIDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2Z8</accession>
    <name>K9Z2Z8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen-dependent coproporphyrinogen-III oxidase</fullName>
            <shortName evidence="4">CPO</shortName>
            <shortName evidence="4">Coprogen oxidase</shortName>
            <shortName evidence="4">Coproporphyrinogenase</shortName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemF</name>
        <name evidence="5" type="ordered locus">Cyan10605_1423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219263.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1423"/>
    <dbReference type="EnsemblBacteria" id="AFZ53534">
        <property type="protein sequence ID" value="AFZ53534"/>
        <property type="gene ID" value="Cyan10605_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1423"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1504"/>
    <dbReference type="eggNOG" id="COG0408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_3"/>
    <dbReference type="OMA" id="WFGGITD"/>
    <dbReference type="OrthoDB" id="1086432at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00333">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for dimerization" evidence="4">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="39435" checksum="E5838F971AC28D6A" modified="2013-03-06" version="1">MSSLVNQPLINNDTKRVLPPSDAREKAKRFVMDLQDKICQGLEEIDGKARFREDKWEREEGGGGRTRVIRDGGIFEQGGVNFSEVWGDTLPPSILMQRPEGAGYGFYATGTSMVLHPKNPYIPTVHLNYRYFEAGPIWWFAGGADLTPYYAFEEDAIHFHQVHKDACDRHHKEYYPTFKRWCDEYFYLKHRKEARGIGGIFFDYQDDSGILYAGSNADGEANAYSEKVGKVSRNWEDLFAFAQSCGDAFLPAYLPIIERRRNTEYGERERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLTRWEYCYTPEKGSPEARLTDYFLTGRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z323</accession>
    <name>K9Z323_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218484.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0614"/>
    <dbReference type="EnsemblBacteria" id="AFZ52753">
        <property type="protein sequence ID" value="AFZ52753"/>
        <property type="gene ID" value="Cyan10605_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0614"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.648"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071416_2_0_3"/>
    <dbReference type="OMA" id="KGTAQEY"/>
    <dbReference type="OrthoDB" id="1375827at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="175" mass="20426" checksum="92D1AA555134CED2" modified="2013-03-06" version="1">MKENLPIIYISILLGLLLIVAILLFRQIIKSRRTESRFSKLQNKLQSQKGTAQEYYELAGIYLDKKLFVQAIQLLQRGLKSDEEIEPENKALMYNALGFAYFSQEQYDIAIRNYKEAIKLYPEYTIALNNLGNVYEKKQLITQAFECYKKTLEFDPKNTVATKRVQSLEKRLVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z345</accession>
    <name>K9Z345_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219358.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1522"/>
    <dbReference type="EnsemblBacteria" id="AFZ53631">
        <property type="protein sequence ID" value="AFZ53631"/>
        <property type="gene ID" value="Cyan10605_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1522"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1617"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_3"/>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="148" mass="16463" checksum="B42DC2B2AEA6FAAC" modified="2013-03-06" version="1">MTLAVGTKAPNFTTKDDQGNTVSLSDFAGKVVVLYFYPKDDTPGCTKEAQSFRDNYTEYQGKDMVVLGVSNDDEASHKMFKEKYGLPFQLLADTDRSITKAYDVEMTYNGQIYPQRVTYIIDGEGTITHVDDKVQTATHAQDILAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z357</accession>
    <name>K9Z357_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">Cyan10605_1532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1532"/>
    <dbReference type="EnsemblBacteria" id="AFZ53641">
        <property type="protein sequence ID" value="AFZ53641"/>
        <property type="gene ID" value="Cyan10605_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1532"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1627"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_0_3"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="175" mass="19273" checksum="3984CD4C8943D13F" modified="2013-03-06" version="1">MSIFAHQIRQKYLLVNMAIFEGNFQDTSNLRFALVIGRFNDLITNKLLSGCQDCLKRHGVDINPEGNQVDYAWVPGSFEVSLVAKKLALTGRYDAIICLGAVIRGDTPHFDYVCNEAAKGIASVGLNTGVPIVFGIVTTDTMQQALERAGIKSNLGWNYAMNALEMATLMKQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z362</accession>
    <name>K9Z362_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisC</name>
        <name evidence="7" type="ordered locus">Cyan10605_0895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218756.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0895"/>
    <dbReference type="EnsemblBacteria" id="AFZ53025">
        <property type="protein sequence ID" value="AFZ53025"/>
        <property type="gene ID" value="Cyan10605_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0895"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.940"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_3"/>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="33"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="42880" checksum="48FE9882B3C55C32" modified="2013-03-06" version="1">MTDFIPSFIREDLLKLSAYIPTPISDNQKQLTRLDANESPYNLPSELRIKLASFYEQEIETNRYPDGSHSVLKRLIVNYVNESINKEGLFNVNNISIGNGSDELIRSILMATCLNNQGSILVANPTFSMYKILAESLGINTISIERNEIDFSWDIDKANQAIRETNNPPIKVIFVVHPNSPTANCLNDSEIAWLKNLPSDILVVIDEAYYEFSKKTLAIELKNYPNWLVLRTFSKAFRLAAHRVGYAIASPAIINVLEKLRLPYNLPTFSQLAAQFAMENRQLILPAVEETIKEKERVFQELNKIKNLKIWRSDANFIYCRLKENGNYENHQNILNQLKEKNILIRHTGGGLRISIGTPEENDYLLSTIQSLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z365</accession>
    <name>K9Z365_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="15" type="ordered locus">Cyan10605_0665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218534.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0665"/>
    <dbReference type="EnsemblBacteria" id="AFZ52803">
        <property type="protein sequence ID" value="AFZ52803"/>
        <property type="gene ID" value="Cyan10605_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0665"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.701"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_3"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="361"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="714"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="970" mass="109311" checksum="1E4B063146B44BB2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3B7</accession>
    <name>K9Z3B7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Valine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
            <shortName evidence="9">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">valS</name>
        <name evidence="16" type="ordered locus">Cyan10605_1540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1540"/>
    <dbReference type="EnsemblBacteria" id="AFZ53649">
        <property type="protein sequence ID" value="AFZ53649"/>
        <property type="gene ID" value="Cyan10605_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1540"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1635"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_3"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025564">
        <property type="entry name" value="CAAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14159">
        <property type="entry name" value="CAAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="635"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="CAAD" evidence="15">
        <location>
            <begin position="788"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="542"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121165" checksum="E5A443920E6AEB9A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3C5</accession>
    <name>K9Z3C5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218826.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0965"/>
    <dbReference type="EnsemblBacteria" id="AFZ53095">
        <property type="protein sequence ID" value="AFZ53095"/>
        <property type="gene ID" value="Cyan10605_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0965"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1019"/>
    <dbReference type="eggNOG" id="COG2314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158532_0_0_3"/>
    <dbReference type="OMA" id="LGQPLWG"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="130" mass="14980" checksum="30765AC6E6999379" modified="2013-03-06" version="1">MVSQLFNFYQQPKKKIFSVVLALIGTVTPLVGLHKLYLGQPLWGLIYFILSWESPMARIACAIDAVLYLAQDSNYFYSRFNPELPLTENNSIDAKQITEVAQAIRELEKLRQDGLISENEFEQKRRKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N1</accession>
    <name>K9Z3N1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sat</name>
        <name evidence="10" type="ordered locus">Cyan10605_1708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219538.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1708"/>
    <dbReference type="EnsemblBacteria" id="AFZ53811">
        <property type="protein sequence ID" value="AFZ53811"/>
        <property type="gene ID" value="Cyan10605_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1708"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1814"/>
    <dbReference type="eggNOG" id="COG2046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_3"/>
    <dbReference type="OMA" id="LQHMIIR"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="174"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="388" mass="44192" checksum="94272DE0F6703B8E" modified="2013-03-06" version="1">MSNIIETIAPHGGHLVNRVATPAERDEFMAQADSLPRIELDDRALSDLVMIAIGGFSPLNGFMAQDDYERVVEEMRLMNGLPWAVPVTLSVSAEVAEPLKEGSWVRLDDHTGRFVGVLELTQKYRYNKTHEAVNVYRTDEEKHPGVKVVYEQGEINLAGPIWLLQRDDHPYFPKYQIDPAESRKMFVERGWKTVVGFQTRNPIHRAHEYIIKCALEIVDGLFLHPLVGATKSDDIPADVRMRCYEIMVDNYFPQNRVILAINPSAMRYAGPREAIFHALIRKNYGCTHFIVGRDHAGVGDYYGTYDAQHIFDEFKPEELGITPLKFEHAFYCTRTNQMATSKTSPATKEERIHLSGTKVREMLRRGELPPPEFSRPKVAAELAKAMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3P8</accession>
    <name>K9Z3P8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219101.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1256"/>
    <dbReference type="EnsemblBacteria" id="AFZ53372">
        <property type="protein sequence ID" value="AFZ53372"/>
        <property type="gene ID" value="Cyan10605_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1256"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1327"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049858_0_0_3"/>
    <dbReference type="OMA" id="KAEINYC"/>
    <dbReference type="OrthoDB" id="1254910at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="143"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="367" mass="42590" checksum="7ACF9979B0D02106" modified="2013-03-06" version="1">MTKKINRDHAQKKHHPLSENDAIVSHLSELLTPSIFAQQSLFRDLGMRNRVLNLSLMTAAILTLLWRNVPSVNELTRILNREGFLWVDPTKVSQKALSDRFLTFPSILFEQVFKQLLPKFKERWQKRTNHPLPDSVCFSLTKFKQIWIVDGSTLEALFRKLDSLKDIPTGKLAGKMAVVMDLATRLPVEIWVEENPSISEVKFEENILNLVKSQTLLLLDRGFYHFLFWQELITRNIDFITRIKKGASIEILKRFTNSHDLRDSLINIGDGRKKTPIVTLRLVEIRSKNKWHSYLTSVTSPEILPPHVVVNLYGKRWRIEEAFNTVKRLLGLSYLWTGSINEIEKTKAEINYCSVSRIGKKSKKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z414</accession>
    <name>K9Z414_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">Cyan10605_1777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219606.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1777"/>
    <dbReference type="MEROPS" id="M41.017"/>
    <dbReference type="EnsemblBacteria" id="AFZ53879">
        <property type="protein sequence ID" value="AFZ53879"/>
        <property type="gene ID" value="Cyan10605_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1777"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1886"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_3"/>
    <dbReference type="OMA" id="LPGCKAH"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939086" description="ATP-dependent zinc metalloprotease FtsH" evidence="7">
        <location>
            <begin position="40"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="623" mass="68350" checksum="CD9FC7404DD3B63F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z425</accession>
    <name>K9Z425_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1206"/>
    <dbReference type="EnsemblBacteria" id="AFZ53325">
        <property type="protein sequence ID" value="AFZ53325"/>
        <property type="gene ID" value="Cyan10605_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1206"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1273"/>
    <dbReference type="eggNOG" id="COG4627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655222_0_0_3"/>
    <dbReference type="OMA" id="GMPYMAH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="422" mass="47641" checksum="4FB4959B0ED70545" modified="2013-03-06" version="1">MDSQKFVQLIPEIFDFDNIESIEAKKNQIASILKKVDSTINPYVFLLLNTAISCLEENEIYCEILKQSSTTLIPILESNPQLMAYGIIDNETIDIDNINYTLESSNYSDQVCIYEGDITSFCEDLQSLDSEDKIGLFHLNGNRPYREILLALMNIRPLLAEEAFIIISQTENGATKNAISDFQNFNNSDNIHELLVVNPETKSYHFMEQELVILLYRNNVINKQIKRINNAGLTKLNQATENHKKTLLHVGCGPSNPNALPQDFRGDDWVEIRLDINPNVQPDIIGTITDLSGVPNNSVDAVYSSHNLEHIYNFEVPIALAEFKRVLKNGGCVMFVVPDMQTAAEWVMRGEMEDSPLYQSPAGPVPALWMFYGMGTTYPGMPYMAHKTGFTTKNLAKQLGEAGFNNLKLIRRSFDIIAYGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z429</accession>
    <name>K9Z429_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219059.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1211"/>
    <dbReference type="EnsemblBacteria" id="AFZ53330">
        <property type="protein sequence ID" value="AFZ53330"/>
        <property type="gene ID" value="Cyan10605_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1211"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1278"/>
    <dbReference type="eggNOG" id="COG3914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022025_0_0_3"/>
    <dbReference type="OMA" id="NTEFISH"/>
    <dbReference type="OrthoDB" id="370520at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="341"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="521"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="724" mass="85431" checksum="3D07A5040DB34C24" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z430</accession>
    <name>K9Z430_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219678.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1849"/>
    <dbReference type="EnsemblBacteria" id="AFZ53951">
        <property type="protein sequence ID" value="AFZ53951"/>
        <property type="gene ID" value="Cyan10605_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1849"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1962"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_3"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="473" mass="53209" checksum="941278888B0E2358" modified="2013-03-06" version="1">MPGTPQEVLKMIQDQNIKIIDLKFIDLPGTWQHCSFYYDQIDESSFVDGVPFDGSSIRGWKAINESDMAMVPDPTTAWIDPFCKEPTLSMICSIKEPRTGEWYSRDPRSIAQKAVEYLAQSGIGDTAYFGPEAEFFVFDDVRFDQTENKGYYYVDSVEGRWNSGKEEEGGNLGYKPGYKQGYFPVPPTDTMQDMRTEMLLTMAECGVPIEKHHHEVATGGQNELGFRFATLIEAADYLMTYKYVIKNVAKKYGRTVTFMPKPLFNDNGSGMHTHQSIWKDGQPLFWGDGYANLSKMALHYIGGILKHAPAILAFSNPSTNSYKRLVPGFEAPVNLAYSQGNRSASVRIPLSGTNPKAKRLEFRCPDATSNPYLAFAAMLCAGIDGIKNEIDPGEPLDVDIYDLSPEELSKIPSTPGSLEQALEALEQDNAFLTEGGVFTEDFINNWIEYKLDNEINPMRLRPHPYEFALYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z447</accession>
    <name>K9Z447_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219246.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1405"/>
    <dbReference type="EnsemblBacteria" id="AFZ53517">
        <property type="protein sequence ID" value="AFZ53517"/>
        <property type="gene ID" value="Cyan10605_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1405"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_3"/>
    <dbReference type="OMA" id="ITYFMDG"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="36"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="36"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="257" mass="28950" checksum="3CDFF167F63E116C" modified="2013-03-06" version="1" precursor="true">MTIIKSFLFSITLCLYLLSSPLVKSAEWEEIQARGKIIVGVKDNLPPLGFTDQNGNLQGFEIDLAHKLAEELLGDKQAIKFVPLLNQDRLNAVIEDDVDIAIASITFNSSRQRLVDFSDIYYFSGTGIIVKKNQFLSNIRDISGKIGILNNSRAIAEIQYQFPQLSLQGVSSYQEALELMEKGEMQGFAGDVMVLTGITQQTSNYQLLPQIIGAYPIAIALPKGRQYQSLRNQVNQVMRKLRQEDWFKEKAKFWGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z455</accession>
    <name>K9Z455_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219089.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1242"/>
    <dbReference type="EnsemblBacteria" id="AFZ53360">
        <property type="protein sequence ID" value="AFZ53360"/>
        <property type="gene ID" value="Cyan10605_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1242"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023355_0_0_3"/>
    <dbReference type="OMA" id="FYGTFFN"/>
    <dbReference type="OrthoDB" id="264427at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="592" mass="63594" checksum="1F8A398F131A864F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z476</accession>
    <name>K9Z476_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219114.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1269"/>
    <dbReference type="EnsemblBacteria" id="AFZ53385">
        <property type="protein sequence ID" value="AFZ53385"/>
        <property type="gene ID" value="Cyan10605_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1269"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1340"/>
    <dbReference type="eggNOG" id="ENOG502Z8MN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098312_0_0_3"/>
    <dbReference type="OMA" id="FPELKFM"/>
    <dbReference type="OrthoDB" id="1461558at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1995" evidence="1">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="251" mass="27881" checksum="9F4A30BA61DA64C1" modified="2013-03-06" version="1">MTVTVIPQSLEEAIIQAKSALKVALESGCTRITIDLVIPEIALKAQYLAQEFADFFSEYGAGLKLFFPDTGAAALARRDWGETEFQVTDIGSSRSPIERKISDTDQVFLVISPSAVEVNLVEKLCNIAGDRPVILLIPQLEDVSIVGIGYAARQLRERFISILESAYYFRPLESAVVLRSYPQLWQVWQQNEENEDYELIAEVPQKPLGENLDRILQGQTEDDSDNNNNTPPPSASGLFASLKSFLKALNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4C7</accession>
    <name>K9Z4C7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="5" type="synonym">rpl27</name>
        <name evidence="7" type="ordered locus">Cyan10605_1096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218949.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1096"/>
    <dbReference type="EnsemblBacteria" id="AFZ53218">
        <property type="protein sequence ID" value="AFZ53218"/>
        <property type="gene ID" value="Cyan10605_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1096"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1160"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_3"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9113" checksum="1960F762A743B3E9" modified="2013-03-06" version="1">MAHKKGTGSTRNGRDSNSKRLGVKRYSGETVTAGSILVRQRGTKVYPGNNVGIGKDDTLFALIEGVVKFENKTTSRKKVSVYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G2</accession>
    <name>K9Z4G2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall hydrolase/autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219354.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1518"/>
    <dbReference type="EnsemblBacteria" id="AFZ53627">
        <property type="protein sequence ID" value="AFZ53627"/>
        <property type="gene ID" value="Cyan10605_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1518"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1613"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031959_0_0_3"/>
    <dbReference type="OMA" id="YGVFWNN"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="470"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="591" mass="65565" checksum="25278558A795F276" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G3</accession>
    <name>K9Z4G3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219754.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1933"/>
    <dbReference type="EnsemblBacteria" id="AFZ54029">
        <property type="protein sequence ID" value="AFZ54029"/>
        <property type="gene ID" value="Cyan10605_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1933"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2054"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_2_3"/>
    <dbReference type="OMA" id="YIVGCFM"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="388" mass="41590" checksum="C5177D411AC2553F" modified="2013-03-06" version="1">MLPLIEAILNGISIGSVLLIAALGLAIVFGLMGVINLAHGELMMIGAYTTFVIQNIFKPLGEPFFDWYIIVAIPVAFIVTALAGLILEKGVIKFLYGRPLETLLATWGVSLILRQFVRSVNGSMAIGLTIFSLLFFGAMFFFSRRQNWLQIRNLFLYITLPLTGAIAITTGILINQSQNKSLTTPWFSARNVDVTAPEWLRGGIPLGDFQFPTARIFIIVLTLLCLAGVYWFLNVTDWGLKIRAVTQNRTMSSCLGIPTATVDALTFALGSGLAGIAGVAISLLGSVGPNTGQNYIVDAFMVVVVGGVGNLLGSIIAAFAIGTVSYIVGSGTLGLIIMSQESLTPLLDIVNFFATTSMAKVLVFVIIIGFLQVKPSGIFPQKGRTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4T1</accession>
    <name>K9Z4T1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1400 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2065"/>
    <dbReference type="EnsemblBacteria" id="AFZ54154">
        <property type="protein sequence ID" value="AFZ54154"/>
        <property type="gene ID" value="Cyan10605_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2065"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2194"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107447_0_0_3"/>
    <dbReference type="OMA" id="YSIFSRT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010802">
        <property type="entry name" value="DUF1400"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07176">
        <property type="entry name" value="DUF1400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1400" evidence="2">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="193" mass="21632" checksum="166463017966AB43" modified="2013-03-06" version="1" precursor="true">MDIKYIKTSRTNSKYRLSSMQLLFFRCLGIVAFSSTMLGFVFPVNASEKVILKYGMWQESLPVSDMTVFCDTGEISTTLSYYIRLSNQSSDRINNVLCKPIAVNGVTLSKMLNNPVGGFILDLFGEVITTPSKKASRESLRGALVTSALENDDISIIEVLNNYPTNEVHLNGDRLVEFYRQVEDVLKIIPVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W1</accession>
    <name>K9Z4W1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219499.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1667"/>
    <dbReference type="EnsemblBacteria" id="AFZ53772">
        <property type="protein sequence ID" value="AFZ53772"/>
        <property type="gene ID" value="Cyan10605_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1667"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1768"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_3"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="263" mass="29156" checksum="E9AF41725C4EE829" modified="2013-03-06" version="1">MMKTPTQPLNINFENLSVTYSNGKLALYNASSSVKQGSITALVGPNGGGKSTLFKAIMGFLKPTVGKVSIGNLSVSEAQKSQLMAYVPQADEVDWDFPVSVFDVVMMGRYGYMNFLRIPSQKDRRLVMESLERVNLVDFRHRQIGELSGGQKKRAFLARALAQEGKVILLDEPFTGVDVKTEKNIIDLLIQLREEGHTILISTHDLASIATFCGHRRCGYADRTILLNRTILAEGVTEETFTEENLTMTFGGLPMNSVKQIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z5</accession>
    <name>K9Z4Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219539.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1709"/>
    <dbReference type="EnsemblBacteria" id="AFZ53812">
        <property type="protein sequence ID" value="AFZ53812"/>
        <property type="gene ID" value="Cyan10605_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1709"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1816"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_1_0_3"/>
    <dbReference type="OMA" id="IDVENWE"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012824">
        <property type="entry name" value="Cbl_biosynth_CobW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02475">
        <property type="entry name" value="CobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="253"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="347" mass="39036" checksum="34F12D0809CB3B3F" modified="2013-03-06" version="1">MHKIPVTVITGFLGAGKTTLLRHLLQNNQGRKIAVLVNEFGEVGIDGDLLRSCQVCDTEEEENNIIELTNGCLCCTVQEEFYPTMQELLTRKDAIDSIIIETSGLALPKPLVQAFKWQEIRTHATVDGVVTVVDAQALANGTLVGDLEALEAQRADDPSLDHETPIEELFEDQLACADLVLLTKTDLISETDLTQVKSWLEKELRQGVKVIPCHQGKINPDILLGFNAAVEDDLNNRPSHHDTEEDHDHDDDINSLELVIPETSNPQDLIQELHRLITKFEIYRIKGFVNVPDKPMRMVLQGVGDRIETFFDRLWKPEDNRVTRLVIIGKNLEKQKINQELNNLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z520</accession>
    <name>K9Z520_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219949.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2136"/>
    <dbReference type="EnsemblBacteria" id="AFZ54224">
        <property type="protein sequence ID" value="AFZ54224"/>
        <property type="gene ID" value="Cyan10605_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2136"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2271"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011736_2_0_3"/>
    <dbReference type="OMA" id="WSDIVEL"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="8"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="405"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="664" mass="79334" checksum="9EB05A338CF824A9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z563</accession>
    <name>K9Z563_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase/aspartoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219282.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1442"/>
    <dbReference type="EnsemblBacteria" id="AFZ53553">
        <property type="protein sequence ID" value="AFZ53553"/>
        <property type="gene ID" value="Cyan10605_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1442"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1527"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_1_3"/>
    <dbReference type="OMA" id="GRTNMLH"/>
    <dbReference type="OrthoDB" id="632656at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="35841" checksum="6848FBCD48632B83" modified="2013-03-06" version="1">MDEKNKEYKIKVAGEIIKPGQVKQIEIPVARLPTQTLICLPVTVINGLEKGARLWVNAAIHGDEINGVEIIRQVANHVNPRLLKGTLITVPIVNVFGFIEQSRYLPDRRDLNRCFPGSETGSLASRLANIFMREVVGKCTHGIDIHTAAIHRINLPQIRANLDDPETMRIAKAFNSPIMIHATTRDGSLRQAASSEGIPTLLYEGGEALRFDQDAIAVGVRGIFRVMKTLGMYDNPVENGKEETSVRVNQSKWLRASQSGIFQLRTKLGAKVEKKQLVGTITDAFGNKTIAVKSNIEGIVISHVQNPLVNQGDALIHIAMTPINPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5F0</accession>
    <name>K9Z5F0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220135.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2327"/>
    <dbReference type="EnsemblBacteria" id="AFZ54411">
        <property type="protein sequence ID" value="AFZ54411"/>
        <property type="gene ID" value="Cyan10605_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2327"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2471"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_3_0_3"/>
    <dbReference type="OMA" id="WRIIGTG"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="19384" checksum="1EA197405C9C284B" modified="2013-03-06" version="1">MGKVLVLNASYEPLNITNWKRAVILLLKGKAEQLEHYENFIYPTFPFPSVIRLRHYVKVPYKDIPLTRRNILERDRHSCQYCGYRGDQLTLDHILPRSRGGADSWENLVTACVRCNIKKGNRTPKEAHMPLHKSPRKPYSSLHFEIVKCTKDNLNHEWRKYVIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I0</accession>
    <name>K9Z5I0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220165.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54441">
        <property type="protein sequence ID" value="AFZ54441"/>
        <property type="gene ID" value="Cyan10605_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2358"/>
    <dbReference type="HOGENOM" id="CLU_2478119_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="87" mass="10238" checksum="F7EE6CBBA55360C4" modified="2013-03-06" version="1">MRDNYDFSQGVKNPYFDCLKTRSKKHMNLKSLFQNEKTRIILGDAITLLNEYIEDESISYLSILLIISAKNSPNFQDRREDEGNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5S9</accession>
    <name>K9Z5S9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_2003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219822.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2003"/>
    <dbReference type="EnsemblBacteria" id="AFZ54097">
        <property type="protein sequence ID" value="AFZ54097"/>
        <property type="gene ID" value="Cyan10605_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2003"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2127"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_3"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="76"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="497" mass="52029" checksum="A6BCA470E1311A9E" modified="2013-03-06" version="1" precursor="true">MVTIPRKRGLRRSLKENQDSIILNFISKITSRISPYWLACIPLTAIIVAVWDGAAMAQGYDGPEDLEQVKIVLDTVFLLFCSVLVIFMNAGFAMLETGFCRQKNAVNILAKNLIVFAIATIAYWAIGFGLMYGEGNGFIGLQGFFFNGDGTPYGDANYPEAVPAAISFLFQVAFAATAATIVSGAVAERVRFDAFLIFSALLVAISYAVTGHWVWDGGWLSELGFSDFAGSTVVHSVGGWAALVGAAVLGPRQGKYSSDGKVSAIPGHNMSIATLGCLILWIGWFGFNPGSELAATANVPYIAVTTNLAAAAGGITATFTSWLKDGKPDLSMIINGILAGLVGITAGCASVGYFSSIIIGAIAGIIVVYSVAMFDQVLKIDDPVGATSVHLVCGIWGTLAVGIFATEGGLLTGGGVALLINQIIGILSIGGFTVAFSFIVWYALQATVGIRVSGEEEVKGLDIGEHGMEAYSGFVKEADILSGGFSSSYSDEVGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U8</accession>
    <name>K9Z5U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1647"/>
    <dbReference type="EnsemblBacteria" id="AFZ53753">
        <property type="protein sequence ID" value="AFZ53753"/>
        <property type="gene ID" value="Cyan10605_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1647"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1749"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022181_1_0_3"/>
    <dbReference type="OMA" id="GINEETN"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="490" mass="53406" checksum="D585A33AB79B21C4" modified="2013-03-06" version="1" precursor="true">MVKMSLTKIAFIFIFNVSPLFVISISKPVQAQTPSSSSDSLLHNALPPLKPTSQRSILPENKAYTLDTGDVIQVTVFGLPDQGGVAQVFNDGTVTFPLIGTVNVRGKTIMEVNDLLASLYSRYLKRPSITVILQQPRPLEVAIVGEVNVPGNYNLSGGTQIQQKEGQTQIASNTPSLPKVSDLFTLAGGLTVSADVRQIQLKRREKGKEVFYVLDFWQLLQEGDLAQDVKLKDGDVIIVPKKDVIDPNEYRQLADATFGIKYVEPPNVTIVGEVNRPGSYTVPIEQGLPRLTTAIQQSGGIRELADIRNIVISRTTRDAKQQKIEVNLWEMLESGDINRDVLLRDGDTIFIPTAKELEPSEAQRLASANFAPDEIVVNVVGSVRNPGSTVLKPNTSLNNAILAAGGFDERRADSSTVELIRVNPNGTVTKRNIPVNLAAEVNEQTNPILKNNDVIVINRSAIAAFGDSVESVLGPIGRSFSLLGFFNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5W0</accession>
    <name>K9Z5W0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1859"/>
    <dbReference type="EnsemblBacteria" id="AFZ53960">
        <property type="protein sequence ID" value="AFZ53960"/>
        <property type="gene ID" value="Cyan10605_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1859"/>
    <dbReference type="eggNOG" id="ENOG503452G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2616075_0_0_3"/>
    <dbReference type="OrthoDB" id="2145772at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="78" mass="9634" checksum="61AD55BBB544A143" modified="2013-03-06" version="1">MKKSTMDNIKEIRDYLYNELCNLESKDKHNRDLMRRKINQLNLLLEMLDNFEEELTRYELMNNTQLKLNHIETQEYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z620</accession>
    <name>K9Z620_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">Cyan10605_2083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219897.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2083"/>
    <dbReference type="EnsemblBacteria" id="AFZ54172">
        <property type="protein sequence ID" value="AFZ54172"/>
        <property type="gene ID" value="Cyan10605_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2083"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2214"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_2_3"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="264" mass="28364" checksum="F95E752BFE568BF4" modified="2013-03-06" version="1">MSSISQRFAELKKQNKCALIPFITAGDPNLATTEKAIQILVEKGADFIELGVPYSDPLADGPVIQAAATRALKKGVCLEDVLRIVRNLKGKIEIPIILFTYYNPIFYRGAENFLGMIAEAGVKGLVVPDLPLEEAEGFLNTAQKKGIEVILLVAPTSPMERIKHIAEKSQGFIYLVSVTGVTGVRSEVQSRVKDLIAQLKTVTDKPIGVGFGISEPSQATQIKDWGADGVIVGSAFVKKLNNGNQEEGLSAIASLCSDLKQAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z647</accession>
    <name>K9Z647_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1954"/>
    <dbReference type="EnsemblBacteria" id="AFZ54050">
        <property type="protein sequence ID" value="AFZ54050"/>
        <property type="gene ID" value="Cyan10605_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1954"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2076"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023909_0_0_3"/>
    <dbReference type="OMA" id="VFHFSGY"/>
    <dbReference type="OrthoDB" id="601140at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011189">
        <property type="entry name" value="UCP_caspase_lke"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007398">
        <property type="entry name" value="Sll0148_caspase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="712" mass="80079" checksum="53B6D44D96AA690F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z691</accession>
    <name>K9Z691_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ordered locus">Cyan10605_2581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220382.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2581"/>
    <dbReference type="EnsemblBacteria" id="AFZ54659">
        <property type="protein sequence ID" value="AFZ54659"/>
        <property type="gene ID" value="Cyan10605_2581"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2581"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2742"/>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041273_1_2_3"/>
    <dbReference type="OMA" id="YHGKLIK"/>
    <dbReference type="OrthoDB" id="1282567at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="39697" checksum="6984C25161010662" modified="2013-03-06" version="1" precursor="true">MLSSFGYTLPVFATASAVAGIRYLDNNLEDNSVEIDLINPPEKAIIPIEQIAKISSNQVLAITRSQPGTNLDITRNTPIWGLVTLTPSQETKIIIEGGEGVGKIIDLGGKSAIYNYAHKLLEFNILNNLKNHSLVEVKIILPEGKKLAEKTSNSAFGVIEGLSLLGTSGISQPLTSKEQLELYQEELINKSKNHDQLIFCIGENGLDLAVKLGFNPSQLVKTANWLGSMLVTASHAKVKSIILLGYHGKLIKLAGNIFHTHHHLADGRLEILTAIASFLGLNQDVCRLLFTAKTTESALEILREFDRNNNSNWTEKIYNYIAEKIAKNSEKYILNHSDFPVKIGVILFNRQRNIIAKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z693</accession>
    <name>K9Z693_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219977.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2166"/>
    <dbReference type="EnsemblBacteria" id="AFZ54252">
        <property type="protein sequence ID" value="AFZ54252"/>
        <property type="gene ID" value="Cyan10605_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2166"/>
    <dbReference type="eggNOG" id="ENOG50338A7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142310_0_0_3"/>
    <dbReference type="OMA" id="EDEWIDI"/>
    <dbReference type="OrthoDB" id="1862646at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="153" mass="18006" checksum="F9E83B1E2B150C28" modified="2013-03-06" version="1">MFSLRLRFQTVASKLKISDLNAPDLNEEHLLEVATKYCQGKLRWAKGKRYDLSDYLILWEIIGIDNIITLENQEGQSLRVAITLRESESKAQSIFYDLKSKQRASIRQELNIDQHWVIAVKWKNFPEEDEWIDILYREIDDDSSSSDCRLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z697</accession>
    <name>K9Z697_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219825.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2006"/>
    <dbReference type="EnsemblBacteria" id="AFZ54100">
        <property type="protein sequence ID" value="AFZ54100"/>
        <property type="gene ID" value="Cyan10605_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2006"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2130"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_4_1_3"/>
    <dbReference type="OMA" id="VLNPYHI"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="171" mass="19466" checksum="93634E276F962C1E" modified="2013-03-06" version="1">MSKAKILQPDLVLGDIVIHITPDVIQRHNLKGLILDVDETLVPWNERIISPELLTWVEEIRPYVDLWLVSNNLSQNRIATIAQYLNLPFIYGAGKPSRRKLREAVKAMNLPLEQIAMVGDRLFTDVLAGNRLGVFTILVEPMISPHAPKKFSIRNFEVWISQQLGVSLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6C2</accession>
    <name>K9Z6C2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220449.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2652"/>
    <dbReference type="EnsemblBacteria" id="AFZ54726">
        <property type="protein sequence ID" value="AFZ54726"/>
        <property type="gene ID" value="Cyan10605_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2652"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2817"/>
    <dbReference type="eggNOG" id="COG0033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_3"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="295"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="435"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="544" mass="59291" checksum="4904AD83343C2314" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J1</accession>
    <name>K9Z6J1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219748.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1927"/>
    <dbReference type="EnsemblBacteria" id="AFZ54023">
        <property type="protein sequence ID" value="AFZ54023"/>
        <property type="gene ID" value="Cyan10605_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1927"/>
    <dbReference type="eggNOG" id="ENOG50343QC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692565_0_0_3"/>
    <dbReference type="OMA" id="VTRIAWE"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938631" evidence="1">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="155" mass="18064" checksum="F07129DB8A0E4C62" modified="2013-03-06" version="1" precursor="true">MSKKNIVCFLLILLLCFIPVQEAHAGNLSLFSSLEWNQEQTNFSKNPQNFSQEIQNRLNSTRDSIGQLALLISHPWGTYDYTRPIFVAPRDGGGIIFEVDIHWHRNLNSRNHVTRIAWEIVNNKHYKASVIWDDSTFSPIHEEEVNDFFRQLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L2</accession>
    <name>K9Z6L2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase subunit A</fullName>
            <ecNumber evidence="11">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220553.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2763"/>
    <dbReference type="EnsemblBacteria" id="AFZ54831">
        <property type="protein sequence ID" value="AFZ54831"/>
        <property type="gene ID" value="Cyan10605_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2763"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2934"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_3"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="458"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="583" mass="64790" checksum="8285DFE16175FAD7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L4</accession>
    <name>K9Z6L4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220497.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2701"/>
    <dbReference type="EnsemblBacteria" id="AFZ54774">
        <property type="protein sequence ID" value="AFZ54774"/>
        <property type="gene ID" value="Cyan10605_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2701"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2866"/>
    <dbReference type="eggNOG" id="COG2268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394190_0_0_3"/>
    <dbReference type="OMA" id="RDNIRAD"/>
    <dbReference type="OrthoDB" id="387521at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <dbReference type="Pfam" id="PF15975"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">PCC 10605</strain>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
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                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
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                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">PCC 10605</strain>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="588" mass="65753" checksum="807EC6771C35FDC7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X3</accession>
    <name>K9Z6X3_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2224"/>
    <dbReference type="EnsemblBacteria" id="AFZ54310">
        <property type="protein sequence ID" value="AFZ54310"/>
        <property type="gene ID" value="Cyan10605_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2224"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2364"/>
    <dbReference type="eggNOG" id="ENOG502ZR3M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="AHCDGPC"/>
    <dbReference type="OrthoDB" id="1789560at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:superoxide dismutase activity"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AFZ54310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="18019" checksum="964C2F647A498E8A" modified="2013-03-06" version="1">MMKLSQAIAQQIKNWFPAQTVSAHCDGPCGVYDPASARITAEAVLSMTKKILALDAPAPGASPAEVVAYNNTLSRYIAIKEEQAQKTKEDLLILWTDYFKPVHLEKYPDLHDTFWKAAKLCSACKVEVSLQHAEELMAAVEKIHNMFWASKERDVTFYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X4</accession>
    <name>K9Z6X4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54889">
        <property type="protein sequence ID" value="AFZ54889"/>
        <property type="gene ID" value="Cyan10605_2822"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1812561_0_0_3"/>
    <dbReference type="OMA" id="REINDYC"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="142" mass="16202" checksum="1973BF1D97F16834" modified="2013-03-06" version="1">MNILEKFTILIVLIIANLTVISCTSQKTLTCRQIKNIITDLNSKIEPALASDNVLEIKAIAQEFEMTREKLLQVEINDNFLSQSTKNLASTYQEYGEVTYDFLQAFTTKNTENAIASKQAVNQLFTKQQQLVREINDYCYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z710</accession>
    <name>K9Z710_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2446"/>
    <dbReference type="EnsemblBacteria" id="AFZ54527">
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        <property type="gene ID" value="Cyan10605_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2446"/>
    <dbReference type="eggNOG" id="ENOG5032YVY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142668_1_0_3"/>
    <dbReference type="OMA" id="KSRDEHI"/>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="98" mass="11201" checksum="7F77D45B58480BC3" modified="2013-03-06" version="1">MNNREAYQGEMEKKLQEWGAKLDELKAKADNIGDNVRAEYDKQMQDLQAKKDNLEEKLAELKSTSDDAWTSVQSGFQSAWEELSAGFEEAFSKFSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z729</accession>
    <name>K9Z729_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_2944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2944"/>
    <dbReference type="EnsemblBacteria" id="AFZ55006">
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        <property type="gene ID" value="Cyan10605_2944"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2944"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3133"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_10_3"/>
    <dbReference type="OMA" id="RLAIVHQ"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="364"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ55006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="605" mass="69331" checksum="3EEAE55887452484" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z738</accession>
    <name>K9Z738_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hopanoid biosynthesis associated radical SAM protein HpnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220735.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2954"/>
    <dbReference type="EnsemblBacteria" id="AFZ55016">
        <property type="protein sequence ID" value="AFZ55016"/>
        <property type="gene ID" value="Cyan10605_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2954"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3143"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052502_0_0_3"/>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="38475" checksum="80C9378FB1EBBC56" modified="2013-03-06" version="1">MAVQLQQAIAVGTYILRQKLQGKKRFPLVLMLEPLFRCNLACPGCGKIQHPLEILKQYLNPEDCFRAVEECGAPIVSIPGGEPLLHPQIAEIVQGLVERRKFVYLCTNGILLEEKLSLFEPSPYLTFSVHLDGLKETHDKCVNREGVFDTAVKAIKTAKAQGFRVSTNTTVFEGTDPQQMQEFFDFLESLNTDGLMISPGYSYEWAPDQEHFLKREQTKALFRQILSPWKNGKKRWNFNHNPLFLDFLMGEKDYDCTPWGSPSYSVLGWQKPCYLMNEGYYQTFQELLDNTNWENYGHKSGNPKCADCMVHCGYEPTAAMDALNMENTGRAITSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z760</accession>
    <name>K9Z760_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ordered locus">Cyan10605_2114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219928.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2114"/>
    <dbReference type="EnsemblBacteria" id="AFZ54203">
        <property type="protein sequence ID" value="AFZ54203"/>
        <property type="gene ID" value="Cyan10605_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2114"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2247"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_3"/>
    <dbReference type="OMA" id="MVSVRIF"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="44266" checksum="4FF388A47CB54BC8" modified="2013-03-06" version="1">MRAQPFPPEMEIQEEDYFDYYYDEPGSEPGSIIIDPEALPTHINLIEYNPIKAYKKSDIQPKDCQSCLNNDLVSWADIQGLGSEKILREIAEVFRLHPLILEDVVNVPQRPKLEDCQNQLLIILHCIKPNSNEMGFTSEQISLVLGKNYLLTFQEDAIDDFSKLRDRIKNNQGKVRNLGADYLAYLILDTLIDNYFPVLEDYGERIELLEDLIVADPTQKTLKEIYNIRRELLALRRSIWPLRNLFNQLTREENELISKEVYIYFRDCYYHTIQILDILETYRELASSLMDVLMSSMSNKMNEVVTLLTIISSIFIPLTFIAGIYGMNFEFMPELEWHWGYFLCLLLMLSIALLMLFFFWQRGWFKFYFSKKTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7B5</accession>
    <name>K9Z7B5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219988.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2177"/>
    <dbReference type="EnsemblBacteria" id="AFZ54263">
        <property type="protein sequence ID" value="AFZ54263"/>
        <property type="gene ID" value="Cyan10605_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2177"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2313"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_3"/>
    <dbReference type="OMA" id="TCLGLDW"/>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="394" mass="43654" checksum="9D1344747F715820" modified="2013-03-06" version="1">MSKIAYLQCTTGIAGDMFLGALVSAGVPLGYLEKSLESLNIIQEYKLQEETVTRNGLGATKIHVHLTSHSHHHHRHLADIEHIINQSNLAPQIKANSLAIFRQLAIAEAKVHNTTIDKVHFHEVGAVDAIVDIVGTCIGLDYLGIEKLYCSSLPTGGGTVKVAHGILPVPVPAVLELLRSRKIPIYSNGIEKELVTPTGAAIVATLTESFGQPPKMSLEKIGNGAGSQDLSLPNILRLWIGEMELSNLEEVAVLETQIDDCNPQILAYVLEELLNIGAKDVFTQPVMMKKSRLGVLLTVICDLDKINICENLIFRETTTLGIRRQIQQRSILEREMTTIKSKYGDIRLKIAKKQGKVVNIHPEYKDCATIARQLDIPINRIQWEVVREFYEKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E7</accession>
    <name>K9Z7E7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220224.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2418"/>
    <dbReference type="EnsemblBacteria" id="AFZ54500">
        <property type="protein sequence ID" value="AFZ54500"/>
        <property type="gene ID" value="Cyan10605_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2418"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2562"/>
    <dbReference type="eggNOG" id="ENOG5031GDF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112658_0_0_3"/>
    <dbReference type="OMA" id="RIYDANN"/>
    <dbReference type="OrthoDB" id="1713217at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="146" mass="15817" checksum="45115DDAFA296156" modified="2013-03-06" version="1" precursor="true">MFYRLIVTFTFSLFLLLSSFIITPPVEALVQIKITDVSYKDCPPGVGEGSVTSGGSALPATCYLVTGKTNNTSGKTLYDADVFGRVYDANNEPALQNRTRLGALPEVPPGISSFELRISVPSNQPTPLKLKQFKATGFTSKVYPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7J5</accession>
    <name>K9Z7J5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55166">
        <property type="protein sequence ID" value="AFZ55166"/>
        <property type="gene ID" value="Cyan10605_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3113"/>
    <dbReference type="eggNOG" id="ENOG502ZXSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2259089_0_0_3"/>
    <dbReference type="OrthoDB" id="2100503at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="103" mass="12163" checksum="6059C719A5F5A6BA" modified="2013-03-06" version="1">MESLFNIWNSSYLDNVNFEILERKNRYANFDEFLAKHPNCCEVDPGGPYDMGAPFFIDRITGYDSGKVISFEFKEEYIYPDGNIRTEKIHILDRLQNCGESYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7K5</accession>
    <name>K9Z7K5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220288.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2484"/>
    <dbReference type="EnsemblBacteria" id="AFZ54565">
        <property type="protein sequence ID" value="AFZ54565"/>
        <property type="gene ID" value="Cyan10605_2484"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2484"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2633"/>
    <dbReference type="eggNOG" id="ENOG502Z8CZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024921_0_0_3"/>
    <dbReference type="OrthoDB" id="109118at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="737" mass="86782" checksum="8E85496122814F16" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T5</accession>
    <name>K9Z7T5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220187.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2380"/>
    <dbReference type="EnsemblBacteria" id="AFZ54463">
        <property type="protein sequence ID" value="AFZ54463"/>
        <property type="gene ID" value="Cyan10605_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2380"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2527"/>
    <dbReference type="eggNOG" id="ENOG502ZAA4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086048_0_0_3"/>
    <dbReference type="OMA" id="FVQAPWV"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021468">
        <property type="entry name" value="DUF3120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11318">
        <property type="entry name" value="DUF3120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="28217" checksum="F5BECCE23C4A6A41" modified="2013-03-06" version="1">MLNHTLLSQLTTLLPSVGEIIFDFLVGWWWDKEKRKRILLFSSSAFLVSIPVFFQAPLVRIFPWLSLLLTFVWVALSFHWRKQPETYIWGDLLWGFSWSWLCGSIYWGWLRYYPSIHIPIEAIGLPFAIWGIRKGWGLIGNYFYLGSLIGTAITDLYFYIDGLIPYWKELMVTDPTLVKPLLQGAIAQVQTIWGISWAILLANTLLGISLWGLVKKKTHHIVFASAVLSTIFTDALFLVAAYLGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U4</accession>
    <name>K9Z7U4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220974.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3209"/>
    <dbReference type="EnsemblBacteria" id="AFZ55256">
        <property type="protein sequence ID" value="AFZ55256"/>
        <property type="gene ID" value="Cyan10605_3209"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3209"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3421"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_0_3"/>
    <dbReference type="OMA" id="QSAVKEY"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="180"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="301"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="403" mass="46480" checksum="A73F032A1CF586B8" modified="2013-03-06" version="1">MKLVQRHLIKPNNQFYQDIDKLTFLSKNLYNCGIYLCRQAFFKGEKIPSQNQLYHQLKGGIDYRLLPSKVSQLVLKQVEKTFKSYQSAVKEYKQNPSKFTGKPKLPRYKDKVKGRNIVTYNYQAISVKYLKKGLVNPSKSNILIKTDIKEILEVRLIPKTGVYLVEIVYEKPEKETIIFDNSAYIDLGLNNLAVLTSNKKGFQPKLICGRALKSCNHYYNKRIAQLKSQLNDKQKTSKRIQSLILKRNNKVDYYLHTASRYIINNLLENNISLLVIGQNKNWKQGIKLGKKNNQNFVNIPHDKLIQQLTYKAQLVGIKVITTEESYTSKCSFLDLEPVKKQEKYLGKRLNRGLFSASNGYLYSADVNGSLNIGRKVVGESVFNRDSIVRFVVDPLRVKSYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V3</accession>
    <name>K9Z7V3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220927.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3158"/>
    <dbReference type="EnsemblBacteria" id="AFZ55209">
        <property type="protein sequence ID" value="AFZ55209"/>
        <property type="gene ID" value="Cyan10605_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3158"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_3_0_3"/>
    <dbReference type="OMA" id="IQANMHE"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9050" checksum="0ED603322C538B0A" modified="2013-03-06" version="1">MNIVNIHQAKTQLSQLLSRVEKGEKIIIANRGKPVAFLTPYTDESLFHQRIPGRLKGQFTVSENFYESDEEIISLFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7V7</accession>
    <name>K9Z7V7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase IS891/IS1136/IS1341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Cyan10605_2590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220388.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2590"/>
    <dbReference type="EnsemblBacteria" id="AFZ54665">
        <property type="protein sequence ID" value="AFZ54665"/>
        <property type="gene ID" value="Cyan10605_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2590"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2751"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_3"/>
    <dbReference type="OMA" id="EDINFRM"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="200"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ54665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="409" mass="47441" checksum="E5ABBE67D4C4D0B1" modified="2013-03-06" version="1">MLNLSYEYKLKPSKFQIEQIEHTLDVCRSIWNFALLERIDWMRSRKSPVNACSIQQEYILSPETKYPNYNEQAKSLTLARKQNKKIADVNAQVEQQVLRTLERAFADREKKNLGFPRFKNLNRMRSFVFPQMLKNCIKGNQIKLPQLGWVKFRQSRPIPDGFLVKQARIVRKATGYFVILSLQSDVDIPQPIPHGHPKGLDIGFICAVVTSDNESIPRPRFLNKYLRELKRLQRMLKKKQKGSCGWKKLQKRIARLHFKTTSHRKDYHFKLSHHLVKDAGMIFVEDINFRMWQRSFLSKSSADFGFGQFIDILEWVCFRTDTYLCKVDHRYTSQGCPECGARTGKKDLKERVHQCPECGYITGRDHASALVIRNRGLDLVAVGQSVQEKASGDGRGGGEFTRLATNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z5</accession>
    <name>K9Z7Z5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220579.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2790"/>
    <dbReference type="EnsemblBacteria" id="AFZ54857">
        <property type="protein sequence ID" value="AFZ54857"/>
        <property type="gene ID" value="Cyan10605_2790"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2790"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2965"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020302_1_0_3"/>
    <dbReference type="OMA" id="NHLNYCS"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="347" mass="37680" checksum="C3E69D396C318E81" modified="2013-03-06" version="1" precursor="true">MSNNNVIVIGAGPAGLAAAGKLQGFGFDVVLIEKQAQVGGHLNKWFKVFPDFTDASEITANLKAGLGSTQILTDTTVTEIKGSAPDFWVTTSHGDTINAQAILVSTGYKHFDASLKEEYGYDIYDNAITSVELDAMLKAGKVTTAQGKVPKKVAMIHCVGSRDEKVNNNYCSRVCCTNAIKVAIEVKEQNPDCQIYCLYMDIRVFGRGYEELYRTSQESHGIQFLRGRLSEASEKPDRSLLLRLEDTLTAKPMRLSVDLMVLMVGMEGNPDLLDVAGLQLGCDRFFATAHQQYSNNHSQRPGIFLAGAATGPKAIMESITDGRSAAAEIAGFLLQQRGISLNKLVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z886</accession>
    <name>K9Z886_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221077.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3314"/>
    <dbReference type="EnsemblBacteria" id="AFZ55359">
        <property type="protein sequence ID" value="AFZ55359"/>
        <property type="gene ID" value="Cyan10605_3314"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3314"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_3"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="43802" checksum="9CCB0555110D33BE" modified="2013-03-06" version="1">MKILVVTHYFPEHKGGVEVVAGEIINQLSKNRVEIKWFASNTDSPPQNNQFLECISIPTSNIIEKKFGFAYPLWSLTIYRQLWRQIKQVDLVHLHEYIYIGNLIAFYIAKKQGKPVIITQHIGFIPFSNKLFSFLLKLVNNTLGKYILSRCDRTVFCSKVIEDYWDSLKTKYKKKPAFIPNGVDTNIFYPVKLEKRLHIKKELNLDSNKLTILFVGRFVEKKGLKLLEKLARNYQEIEWLFAGWGSLNPKQWNLNNVHVWENLQKSQLTPLYQCADLLILPSVGEAFPLVIQEAMACGTPAFVSDESANQYPQLEGLIFSASVNYSHSEDEWSRKLEEIVSQGEYLASLREAVSEFAQNYWSWEKTSSSYHSLFQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8A5</accession>
    <name>K9Z8A5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220681.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2900"/>
    <dbReference type="EnsemblBacteria" id="AFZ54962">
        <property type="protein sequence ID" value="AFZ54962"/>
        <property type="gene ID" value="Cyan10605_2900"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2900"/>
    <dbReference type="eggNOG" id="ENOG5033J3N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2382875_0_0_3"/>
    <dbReference type="OMA" id="QAKWEYL"/>
    <dbReference type="OrthoDB" id="1973059at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="88" mass="10347" checksum="8BF7083FF77B0D9A" modified="2013-03-06" version="1">MEATKVIGMIDNQGQLIIKEKINLSPGKVEIVILKSENINIQDNEKKESKIKFKNQTFRDLLENQNPTDENYDVDEQKWSYLKEKHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D5</accession>
    <name>K9Z8D5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lpxD</name>
        <name evidence="7" type="ordered locus">Cyan10605_3414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221174.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3414"/>
    <dbReference type="EnsemblBacteria" id="AFZ55456">
        <property type="protein sequence ID" value="AFZ55456"/>
        <property type="gene ID" value="Cyan10605_3414"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3414"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3638"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_3"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="6">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="348" mass="37464" checksum="7FCFDBFFE33EB384" modified="2013-03-06" version="1">MKFSDLIHRLSPQYHSFDSHPHLNPELTNIAPIDQADVNSLSYIEGDKFANMIAITKASALILPLDSALQTQATEKGIAWLASPYPRLTFAQAIDIFYKPYKPSAQIHSTAVIADDVQLGENVSIGAHVVIEKGCKIGDDVCIFPNVVVYPDVTIGDRTLLHANCTIEERTHIGKDCVIHSGAVIGGEGFGFVPTQEGWYKMQQSGYVILEDGVEIGCNSTIDRPAVGVTKIGKNTKLDNLVHIGHNGDIGENCAFAAQVGLAGGVKIGNRVILAGQVGVANQVQIEDNAIASAQTGIHHNVKAGETVSGSPAVSNKLYLKVSAIYKKLPEIYKNVKELQKKFNQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8D7</accession>
    <name>K9Z8D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221132.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3372"/>
    <dbReference type="EnsemblBacteria" id="AFZ55414">
        <property type="protein sequence ID" value="AFZ55414"/>
        <property type="gene ID" value="Cyan10605_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3372"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3590"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067823_2_0_3"/>
    <dbReference type="OMA" id="PSYHIGA"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="58"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="21482" checksum="00A8C081962E6E1A" modified="2013-03-06" version="1">MSDENLKALAKEIKIQFTILGVFVIIFWLIEIINLTFFGDRLDSLGIMPRSLIGLRGIILAPFLHGDIPHLIANTFPFVILGFLTMLRKTSDFFIVTFFSMIISGLGVWLFASPNSITVGASGVIFGFLGFLMFRGLFQKNIPSIAVSLIVIFLYGGMVWGVLPTDPRISWLAHLFGFFGGVLAAKFIADNQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8E6</accession>
    <name>K9Z8E6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ordered locus">Cyan10605_3382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221142.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3382"/>
    <dbReference type="EnsemblBacteria" id="AFZ55424">
        <property type="protein sequence ID" value="AFZ55424"/>
        <property type="gene ID" value="Cyan10605_3382"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3382"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3600"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_3"/>
    <dbReference type="OMA" id="SMEMTIE"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017848">
        <property type="entry name" value="RNA_pol_sigma_RpoD_cyanobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02997">
        <property type="entry name" value="Sig70-cyanoRpoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="386" mass="44705" checksum="5DB2CB4435643896" modified="2013-03-06" version="1">MTQAREILATISPVNDLEEMFDYNSSVSGREGELSEMIVEADSIGVADVSSKKSRKLSATPRRRGQSKKKPFTEDSIRVYLQEIGRIRLLRAEEEIELARQIADLLDLEYIRSTLIEHLGRVPTDEEWAIASDMPNMRQFNRRLHIGRKAKDKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFSTYATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKMLSQKMGRKPTEEEIAEDMEMTIEKLRFIAKSAQLPISLETPIGKEEDSRLGDFIEADGETPEDEVSKNLLREDLENVLDSLSPRERDVLRLRYGLDDGRMKTLEEIGQIFNVTRERIRQIEAKALRKLRHPNRNSILKEYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J0</accession>
    <name>K9Z8J0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220627.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2838"/>
    <dbReference type="EnsemblBacteria" id="AFZ54905">
        <property type="protein sequence ID" value="AFZ54905"/>
        <property type="gene ID" value="Cyan10605_2838"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2838"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3016"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_3"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="274" mass="30989" checksum="4A2C60D7DC8B66E1" modified="2013-03-06" version="1">MIQDKLTSLKKIFQEMGQALVAYSGGIDSTLVAKIAYDCLGDRTLAITAVSPSLLPEELDEAQQQAEFMGINHELIETEEMNNPNYTSNPVNRCYFCKSELHDKLKQIAQERGYPYIIDGVNADDLQDYRPGIQAAKERGVRSPLAEVGITKMEVREISKQLGLPWWEKPSQPCLSSRFPYGEEITYEKLHRVGRAEIYLRKLGYSNLRVRSDGNTARIELLPEQISHFVVNVNIPDLVKDFQNLGFTYVTLDLEGYRSGKLNQILGVQGSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8K1</accession>
    <name>K9Z8K1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
            <plasmid evidence="8">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221244.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3491"/>
    <dbReference type="EnsemblBacteria" id="AFZ55526">
        <property type="protein sequence ID" value="AFZ55526"/>
        <property type="gene ID" value="Cyan10605_3491"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3491"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034823_0_0_3"/>
    <dbReference type="OMA" id="NAPLVEW"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="567" mass="65004" checksum="6376192DEDF299C3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z994</accession>
    <name>K9Z994_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photosystem II D2 protein</fullName>
            <shortName evidence="13">PSII D2 protein</shortName>
            <ecNumber evidence="13">1.10.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Photosystem Q(A) protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psbD</name>
        <name evidence="16" type="ordered locus">Cyan10605_3251</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2</text>
            <dbReference type="Rhea" id="RHEA:36359"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.10.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <text evidence="13">The D1/D2 heterodimer binds P680, chlorophylls that are the primary electron donor of PSII, and subsequent electron acceptors. It shares a non-heme iron and each subunit binds pheophytin, quinone, additional chlorophylls, carotenoids and lipids. There is also a Cl(-1) ion associated with D1 and D2, which is required for oxygen evolution. The PSII complex binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cellular thylakoid membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.9" evidence="13"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221015.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3251"/>
    <dbReference type="EnsemblBacteria" id="AFZ55297">
        <property type="protein sequence ID" value="AFZ55297"/>
        <property type="gene ID" value="Cyan10605_3251"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3251"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3465"/>
    <dbReference type="eggNOG" id="ENOG502Z8JK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077965_0_0_3"/>
    <dbReference type="OMA" id="VNIFRAF"/>
    <dbReference type="OrthoDB" id="410807at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010242">
        <property type="term" value="F:oxygen evolving activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01383">
        <property type="entry name" value="PSII_PsbD_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036854">
        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005868">
        <property type="entry name" value="PSII_PsbD/D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PTHR33149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00256">
        <property type="entry name" value="REACTNCENTRE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="SSF81483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01152">
        <property type="entry name" value="psbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="11 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 13" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="13" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="7 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>ChlzD2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pheophytin a</name>
            <dbReference type="ChEBI" id="CHEBI:136840"/>
            <label>D2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>PD2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a plastoquinone</name>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <label>Q(A)</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ55297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="351" mass="39424" checksum="BD65E19FD5893185" modified="2013-03-06" version="1" precursor="true">MTIAVGRVPERGWFDVLDDWLKRDRFVFVGWSGILLFPCAYLALGGWLTGTTFVTSWYTHGLASSYLEGANFLTVAVSSPADVFGHSLLFLWGPEAQGDFTRWCQIGGLWPFVALHGAFGLIGFMLRQFEIARLVGIRPYNAIAFSAPIAVFVSVFLMYPLGQSSWFFAPSFGVAGIFRFILFFQGFHNWTLNPFHMMGVAGVLGGALLCAIHGATVENTLFQDGEQANTFRAFEPTQAEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLGFNLRAYDFVSQELRAAEDPEFETFYTKNILLNEGLRAWMAPQDQPHEKFVFPEEVLPRGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9B6</accession>
    <name>K9Z9B6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220702.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2921"/>
    <dbReference type="EnsemblBacteria" id="AFZ54983">
        <property type="protein sequence ID" value="AFZ54983"/>
        <property type="gene ID" value="Cyan10605_2921"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2921"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3108"/>
    <dbReference type="eggNOG" id="ENOG50330CE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180541_1_1_3"/>
    <dbReference type="OMA" id="GYWGVRF"/>
    <dbReference type="OrthoDB" id="1974067at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010258">
        <property type="term" value="P:NADH dehydrogenase complex (plastoquinone) assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021495">
        <property type="entry name" value="CRR42-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11347">
        <property type="entry name" value="DUF3148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="76" mass="8533" checksum="7C74E0DB424C1ABA" modified="2013-03-06" version="1">MEKKLPIFKTGDRVRIIALPPYLKTADPMPMLRPNSAIALGEEGIIIKQNFGGYYSIRFTQGAYLLESKYIALADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9F9</accession>
    <name>K9Z9F9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circadian clock protein kinase KaiC</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kaiC</name>
        <name evidence="4" type="ordered locus">Cyan10605_3317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The interaction with KaiA enhances its phosphorylation status, while the interaction with KaiB decreases it. A KaiA dimer is sufficient to enhance KaiC phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer; hexamerization is dependent on ATP-binding. Core component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. Interacts directly with SasA.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The KaiC domains mediate the interaction with KaiA.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated on serine/threonine residues by autocatalysis. Both phosphorylated and unphosphorylated forms exist. Can probably autophosphorylate and autodephosphorylate. Phosphorylated form correlates with clock speed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KaiC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221080.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3317"/>
    <dbReference type="EnsemblBacteria" id="AFZ55362">
        <property type="protein sequence ID" value="AFZ55362"/>
        <property type="gene ID" value="Cyan10605_3317"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3317"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3531"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_1_3"/>
    <dbReference type="OMA" id="MGSHSIT"/>
    <dbReference type="OrthoDB" id="271085at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01836">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013503">
        <property type="entry name" value="Circadian_KaiC_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02655">
        <property type="entry name" value="circ_KaiC"/>
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    </dbReference>
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        <property type="entry name" value="KAIC"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="256"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="514" mass="57618" checksum="146A38CC0FEB235D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="Cyan10605_3239"/>
    </dbReference>
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    <dbReference type="OMA" id="IINIHIE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08972">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1902" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="79" mass="9211" checksum="B2BE8E1B8442289C" modified="2013-03-06" version="1">MKTLIRLKIEMFKEDNITYFVATSDDLEGLVAEGETIEQVLEIAQDVAKILLEFEQNNNNKNIIKDIPNEFEYPLFMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9N1</accession>
    <name>K9Z9N1_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3029"/>
    <dbReference type="EnsemblBacteria" id="AFZ55088">
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        <property type="gene ID" value="Cyan10605_3029"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1624383_0_0_3"/>
    <dbReference type="OMA" id="LAIMNEM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="163" mass="19457" checksum="3636B7D269B99ADC" modified="2013-03-06" version="1">MDITTKEIEQLEYALFEEEVRLKREHIELKKELKLLSEKLPQTLLSSHKFNIMMQMENIEKKIKNDLIMLARKKDEIERKKSYQRILDYKRQEQLYKAKEALAKIKSEINQKKSHPSYSINSRVVVNSKISKYEELYSEIKNNLSSLSIDQKLELAELLLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55148.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AFZ55148"/>
        <property type="gene ID" value="Cyan10605_3092"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3092"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="94" mass="10020" checksum="BB7024F11C06DAF6" modified="2013-03-06" version="1">MLDKIKNMYQNDPLKTIAIGVGAVIIAPTVASLLKPVAKATIKTGVILYQKTKETIAETGEQLGDLVAEAQAEVLAEKAENRDNITVLNPSSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9V5</accession>
    <name>K9Z9V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase assembly chaperone hypC/hupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221220.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3466"/>
    <dbReference type="EnsemblBacteria" id="AFZ55502">
        <property type="protein sequence ID" value="AFZ55502"/>
        <property type="gene ID" value="Cyan10605_3466"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3466"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3691"/>
    <dbReference type="eggNOG" id="COG0298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_2_2_3"/>
    <dbReference type="OMA" id="EYTIVHA"/>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="9120" checksum="E3E1E0A5BD408FE9" modified="2013-03-06" version="1">MCLAVPGKVIEIISSDNLLDLKGKISFAGIIKEVCLAYVPEVKINDYVIVHAGFALSIIDEQEAKQTLDDLATIKNFDEGVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA35</accession>
    <name>K9ZA35_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220931.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3162"/>
    <dbReference type="EnsemblBacteria" id="AFZ55213">
        <property type="protein sequence ID" value="AFZ55213"/>
        <property type="gene ID" value="Cyan10605_3162"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3162"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3370"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_3"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="353" mass="37827" checksum="A88FEFE7D878FC36" modified="2013-03-06" version="1">MLTQESILEILKPVQDPELQKSLVELNMIRNVSVEDGNVSFTLVLTTPACPLREFIVEDCEKAVKQLEGVKSVTVDVTAETPQQKPLPDRQSVNQVKNIIAISSGKGGVGKSSVSVNVAVALAQSGAKVGLLDADIYGPNAPTMLGLNDVPINVEKSPQGDILQPAFNHGIKMVSMGFLINPDQPVMWRGPMLNGIIRQFLYQVNWGELDYLIVDMPPGTGDAQLTLAQSVPLAGAVIVTTPQNVSLQDARRGLKMFEQLGINILGIVENMSYFIPPDMPDKSYDLFGSGGGEKASKELNVPLLGCIPLEISLREGGDRGIPIVALQPQSASAQALKKIAQQIAGKVSVMALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAB0</accession>
    <name>K9ZAB0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221248.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3496"/>
    <dbReference type="EnsemblBacteria" id="AFZ55530">
        <property type="protein sequence ID" value="AFZ55530"/>
        <property type="gene ID" value="Cyan10605_3496"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3496"/>
    <dbReference type="HOGENOM" id="CLU_120435_3_0_3"/>
    <dbReference type="OMA" id="TAYPAIY"/>
    <dbReference type="OrthoDB" id="2025638at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="115" mass="12356" checksum="CF95768B239F8DB0" modified="2013-03-06" version="1">MDKLITNIASLGVSGLILLFLMFFSGYTGAAAITTALATLGGPLGMLGGIGVLLLLTKISEGIAEYGFENIAKGVVTEMRNKGKTKLEIVLEIEQFPLISVELKQKLIKFAKEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAC2</accession>
    <name>K9ZAC2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221257.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3507"/>
    <dbReference type="EnsemblBacteria" id="AFZ55540">
        <property type="protein sequence ID" value="AFZ55540"/>
        <property type="gene ID" value="Cyan10605_3507"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3507"/>
    <dbReference type="eggNOG" id="ENOG5032XGI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157259_0_0_3"/>
    <dbReference type="OMA" id="QRFRLWG"/>
    <dbReference type="OrthoDB" id="1744332at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="105" mass="12419" checksum="5CBDE56AF5045B22" modified="2013-03-06" version="1">MTILYEDEYIICDDDALTILYYYFPFGDKRIPYKKINQVSTQEMTWWTGKARIWGGSLSYWLNLDPKRPCKDKLIIIDEGELTKPVITPDNPEQVYQILLSEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ29</accession>
    <name>K9YZ29_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="12" type="ordered locus">Cyan10605_0020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217913.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0020"/>
    <dbReference type="EnsemblBacteria" id="AFZ52181">
        <property type="protein sequence ID" value="AFZ52181"/>
        <property type="gene ID" value="Cyan10605_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0020"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.21"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_3"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="297" mass="32444" checksum="A852AC2256943BAC" modified="2013-03-06" version="1">MSNYIFGRVLTAMVTPFNGDGSVNYGVAEKLADHLVNNGSDGLVICGTTGESPALESDEKYQLLKVVKNAVGDRAKIVMGTGSNSTQKAITETKKASQIGIDGSLQVVPYYNKPPQEGLYQHFGAIARSCPDVPIMLYNIPGRTGKNLEAETTAQLAQDFDNIVAVKEASADLDQTAKINRIAPPDFLIYSGEDFLTLPMMTVGCVGVVSVASHLVGKQMQMMIQSYEKGDNFQAQKIQKQLYPLFKVLFCNTNPIPVKYALQLQGWDIGGFRLPLCNLPPHQQKEVEEVLNNLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZS6</accession>
    <name>K9YZS6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218188.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0308"/>
    <dbReference type="EnsemblBacteria" id="AFZ52456">
        <property type="protein sequence ID" value="AFZ52456"/>
        <property type="gene ID" value="Cyan10605_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0308"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.320"/>
    <dbReference type="eggNOG" id="ENOG502Z8TC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353512_0_0_3"/>
    <dbReference type="OMA" id="FTAYQDF"/>
    <dbReference type="OrthoDB" id="1199790at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="22796" checksum="EAC1A3C6A371AB47" modified="2013-03-06" version="1">MTYTTEELIHFLELELRATWGGKRLIFNAEEKLDNPVVAKAVDLEKMSRVFVFRDFRQQIHEYQQKHQVSGVVWRKVTFKGQTISFPEIHNQLIPIEGDKEILIDAKFPVIEFWQKVTEGLKYYLSGDRTSPITESILEELYQEAQWAEIDAGKEEVYLGLCWGNPKEYIYKWAKPESGFHRIIAAENTPSTINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z019</accession>
    <name>K9Z019_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mg chelatase, subunit ChlI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218245.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0369"/>
    <dbReference type="EnsemblBacteria" id="AFZ52514">
        <property type="protein sequence ID" value="AFZ52514"/>
        <property type="gene ID" value="Cyan10605_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0369"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.388"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_3"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="212"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="507" mass="55542" checksum="7BA2663AD6D0AA2E" modified="2013-03-06" version="1">MLSRVWSATIIGIEGVKVGVEVDVSGGLPKTTVVGLPDTAVQESRERVKAALKNSGFAFPVRQITINLSPADLRKEGPIFDLPISIGILAASEQVDPTYLEQFLFLGEVSLDGSLRAIAGVLPMAVTASKLGFKGIVVPKDNAQEASVVEQIEVYGLNNINEVADFLQNPSAFSPTIPELNFDDSFHQSNYNLRDVKGQHHARRALEIAAAGGHNLIFVGPPGAGKTMLARRMASILPPLSFSEALEVSQIYSVAGLLKNQGKLIQERPFRSPHHSASGVALVGGGSFPKPGEISLSHRGILFLDELTEFKRSVLEFLRQPLEDGFVTISRARQSVAFPAQFTLVASTNPCPCGYYGDTIQPCSCSPRQREQYWAKLSGPLLDRIDLQVVVSRLKPEEMTQQKVGEDSEVVKERVAKARIKAQNRFHNAKISCNAQMRSQHLREYCSLDDTSRTLLENAIRKLGLSARAMDRILKVSRTIADLAGENNIQPPHIAEAIQYRTIDRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0H9</accession>
    <name>K9Z0H9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52686">
        <property type="protein sequence ID" value="AFZ52686"/>
        <property type="gene ID" value="Cyan10605_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0545"/>
    <dbReference type="HOGENOM" id="CLU_3268863_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="41" mass="4695" checksum="7F20DB43EBBDEE19" modified="2013-03-06" version="1">MPKAFLLLMTNLLLMTKSLNLVNKLTAILSLNDKFFDENPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q6</accession>
    <name>K9Z0Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0150"/>
    <dbReference type="EnsemblBacteria" id="AFZ52307">
        <property type="protein sequence ID" value="AFZ52307"/>
        <property type="gene ID" value="Cyan10605_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0150"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108522_0_0_3"/>
    <dbReference type="OMA" id="SSDRHWT"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="25118" checksum="32D8D9C378E25B2E" modified="2013-03-06" version="1">MIERILEPEVMNDDLEAQEYDQMDFTEVNTDFALLASKLGKEQSKVLDVGTGTARIPLILADFCPQWHITAIDLASSMLKIAEKNIQEKNKSSQISLQLVDGKKMPYPDNSFDLIISNSLIHHIPQPLELLKEINRVVKTNGAILIRDLFRPESEDDIEKIVQEANLDYSPRQKQLFKDSLRAALTVDEIKDLAHEMEWHSAKVYQSSPRHWTLRHSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0X0</accession>
    <name>K9Z0X0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CO2 hydration protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218114.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0228"/>
    <dbReference type="EnsemblBacteria" id="AFZ52382">
        <property type="protein sequence ID" value="AFZ52382"/>
        <property type="gene ID" value="Cyan10605_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0228"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.237"/>
    <dbReference type="eggNOG" id="COG2441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707219_0_0_3"/>
    <dbReference type="OMA" id="LMQDMRH"/>
    <dbReference type="OrthoDB" id="322270at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010220">
        <property type="entry name" value="CO2_hydration"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10216">
        <property type="entry name" value="ChpXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01964">
        <property type="entry name" value="chpXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="376" mass="43135" checksum="DD27AE7633414103" modified="2013-03-06" version="1">MVTTPLQPSKHPLAKYIHRLESGKALLKNSPDNLIEVVGILKSYGVVLDRYSINLNYIAENQFLVLFPFFKYFDGQFSWNKLFRHWWHDRINYEYAEYCMRGMLWHGGGKLDDYLDSPEFNRYCQDAIAAKIKGNLLVSSLNGLFPEFLPEQVKMLAYYSALGQFWRVMSDMFLSLSDRYDNGEIESISDVVKHILDGLVESANKPITYAVEIKGKTYQLIPESAGLTFLMDTAVPYVEAVFFRGTPFLGTISYNAQANQIPSDQGSFNYGALYADPLPVGSAGIPPTLLMQDMRHFIPDYLHEFYRQTPRQEDDLLVKICISFQKSMYCVTTAALQGLAPYPLTTENPKEKLANRQYLEQWMNRFTTSRILDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z129</accession>
    <name>K9Z129_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218600.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0735"/>
    <dbReference type="EnsemblBacteria" id="AFZ52869">
        <property type="protein sequence ID" value="AFZ52869"/>
        <property type="gene ID" value="Cyan10605_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0735"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="235" mass="26722" checksum="FD7F064E954AD097" modified="2013-03-06" version="1">MSRILVIDDDPAITELVSINLEMAGYTTAQAEDGIKGQALALQMQPDLIMLDLMLPKVDGLTVCQRLRRDERTANIPVLMLTALGQTQDKVDGFNAGADDYLTKPFEVEEMLARVKALLRRSERTSPVAKHSEILSYGPLTLVPERFEAIWFEKTIKLTHLEFELLHCLLQRHGQTVPPSDILKEVWGYDPDDDIETIRVHVRHLRTKLEPDPRKPRYIKTVYGAGYCLELNTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z137</accession>
    <name>K9Z137_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">Cyan10605_0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0299"/>
    <dbReference type="EnsemblBacteria" id="AFZ52447">
        <property type="protein sequence ID" value="AFZ52447"/>
        <property type="gene ID" value="Cyan10605_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0299"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.311"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_1_2_3"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="204" mass="23189" checksum="E3CDBF53008D44E0" modified="2013-03-06" version="1">MKGNNIKSKIIGLTGGIATGKSTVSNYLRDKYYIPVFDADIFARDAVKVDSPIFVSIIERYGSDILLDNNTLNRSKLGTIIFNDIREKEWLESQIHPFVYNCFRSLIPTLTEEINIFTIPLLFEANMTDLVSEIWVVTCDYEQQLTRLQSRNNLSKKDAIARINSQMSLTEKVQLADVVIDNNGNLTQLIAQIDGIMSSYFHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z166</accession>
    <name>K9Z166_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_0330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218209.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0330"/>
    <dbReference type="EnsemblBacteria" id="AFZ52477">
        <property type="protein sequence ID" value="AFZ52477"/>
        <property type="gene ID" value="Cyan10605_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0330"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.344"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039914_2_0_3"/>
    <dbReference type="OMA" id="IPMYICA"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="37976" checksum="0E22B95A2318AE0D" modified="2013-03-06" version="1">MTQIYSAFTLFTSLLVEAMPFLLMGVLLSSSLILFFDEGNLIKRIPNHPFLGSIIGSLFGFFFPVCECGNIPVARRLLLQGLPTSVAISFLLAAPTINPIVLWSTYVAFRGQPEVFWLRIIFSLTIAIAVGCIFSLQKDPRPLLKPLLAKRLTVIFEQMEAKKSLQTSPSQPEYSLLQSGSFLLSPQGQTVKMDQTLLKSPVNPKSQVSKSYKWNLFISNVTNELRELGGVLILGSAIAASIQVFVPREIILNLGQDTITSIISMMILAAVVSICSTVDSFFVLSFASTFTTASLVAFLVFGPMIDIKAIGLMLSIFKPRMIVYLMVIVAQLTFILTLSYNYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1F9</accession>
    <name>K9Z1F9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytoene dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_0874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This enzyme converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol</text>
            <dbReference type="Rhea" id="RHEA:30287"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:48717"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <cofactor evidence="6">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carotenoid biosynthesis; lycopene biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218735.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0874"/>
    <dbReference type="EnsemblBacteria" id="AFZ53004">
        <property type="protein sequence ID" value="AFZ53004"/>
        <property type="gene ID" value="Cyan10605_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0874"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.919"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022687_1_0_3"/>
    <dbReference type="OMA" id="HSMIFNQ"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="UniPathway" id="UPA00803"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014102">
        <property type="entry name" value="Phytoene_desaturase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02731">
        <property type="entry name" value="phytoene_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="52696" checksum="D5157EEE50F03607" modified="2013-03-06" version="1" precursor="true">MRVAIAGAGLAGLSCAKYLADAGHTPIVLERRDVLGGKVAAWKDEDGDWYETGLHIFFGAYPNMLQLFHELGIEDRLQWKEHTMIFNQPEKPGTYSRFDFPDIPAPLNGLVAILRNNDMLTWGEKIKFGMGLLPAIIQGQDYVEEMDKYSWSEWMAKQNIPPRIEKEVFIAMSKALNFINPDEISATILLTALNRFLQEKNGSKMAFLDGSPTERLCQPIVDYITERGGEVRLNAPLKEILLNEDGSVKGFLIRGLNGEADEVFEADLYVSAMPVDPLKVILPASWKEISFFQKLEGLEGVPVINLHLWFDRKLTDIDHLLFSRSPLLSVYADMSNTCKEYSNPDRSMLELVLAPAAEWISKSDEEIIEATMQELRQLFPQHFTGENQAKLLKSHVVKTPRSVYKATPGRQAYRPDQKTPISNFYLAGDYTMQRYLGSMEGAVLSGKQAAQVISKDFPATVAKPEASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G7</accession>
    <name>K9Z1G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218308.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0433"/>
    <dbReference type="EnsemblBacteria" id="AFZ52577">
        <property type="protein sequence ID" value="AFZ52577"/>
        <property type="gene ID" value="Cyan10605_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0433"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.456"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102570_0_0_3"/>
    <dbReference type="OMA" id="TCGTDSH"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="236" mass="26876" checksum="7B764A7C45EDA0D6" modified="2013-03-06" version="1">MLLKAETNPFQLLDERPQDTVRLANVWERVDNNSCPYQYNFHLHTSCSDGQLTPESLIEQAIALGLKGLAISDHHSVKGFYRAYKWLQEKSKFNPRVSLPYLWTGIEITSELNGTNVHILGYGFDPESEHLQKYLTGENPEGKNAKAEKVIKSLHRAGGLVVLAHPFRYRRSAEELIREAYEVGIDGVEVYYAYGNPQPWIPSVKQTTQALKLARRYNLYTTCGTDTHGNNILIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1L1</accession>
    <name>K9Z1L1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218348.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0475"/>
    <dbReference type="EnsemblBacteria" id="AFZ52617">
        <property type="protein sequence ID" value="AFZ52617"/>
        <property type="gene ID" value="Cyan10605_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0475"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.503"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_4_3"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="30333" checksum="E8A3AC6E2C39B4F5" modified="2013-03-06" version="1">MSESSNLLKKQKLLDIAILAAQEGGAILKQYWGKQLDIREKGRSGDLITEVDQKSEEKVLSVIKRHYPDHGILAEESGTIGIQESEYLWVIDPLDGTTNYAHGYPQAAVSIGLLASGKPLVGVVYNPIREELWSAADGLGATLNRVPIRVSRTNNLTNSLLVTGFAYDRRETEDNNYAEFCYLTHLTQGVRRGGSASLDLCDVATGRLDGYWERGLKPWDLLAGVVIVKEAGGFVTAYDGSEFDLDSGRILATNGYIHSQLSNALGNTPHNTAFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M1</accession>
    <name>K9Z1M1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFZ52248"/>
        <property type="gene ID" value="Cyan10605_0089"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.91"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glucose metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
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        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <position position="159"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="39"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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            <position position="83"/>
        </location>
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        </ligand>
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        <location>
            <position position="125"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
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        <location>
            <position position="241"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="323"/>
        </location>
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        </ligand>
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        <location>
            <position position="186"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AFZ52248.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="37159" checksum="EF0380E42733C50C" modified="2013-03-06" version="1">MESSMSKVKVAINGFGRIGRLVFRAGLANPNIEFVGINDLVPPKNIAYLLKYDSTHGRFQGKVETTEEGILVDDKLIPCYSIRNPEELPWKDNQAEYVVESTGLFTDYEGAKKHLIAGAKKVVISAPTKTPEQIPTLLVGVNHHNYDPTKDDIVSNASCTTNCLAPIAKVIDDNFGLAEGLMTTVHAMTATQPTVDGMSKKDLRGGRSAAQNIIPASTGAAKAVALVLPQLKGKLTGMAFRVPTPNVSVVDLTFRTEKPTSYEEICLRMKEASEGELKGVLGYTDEPVASSDFISDAHSSIFDAGAGIELNSHFFKVVSWYDNEWGYSNRMIDLILSMAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1N4</accession>
    <name>K9Z1N4_CYAAP</name>
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        <submittedName>
            <fullName evidence="10">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0343</name>
    </gene>
    <organism evidence="10 11">
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            <taxon>Chroococcales</taxon>
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        </lineage>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="sensory_box"/>
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    </dbReference>
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        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="505"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="832" mass="94728" checksum="78C8822B23949FE6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1Y9</accession>
    <name>K9Z1Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218927.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1072"/>
    <dbReference type="EnsemblBacteria" id="AFZ53196">
        <property type="protein sequence ID" value="AFZ53196"/>
        <property type="gene ID" value="Cyan10605_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1072"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1134"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_3"/>
    <dbReference type="OMA" id="PLGAIHN"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="35746" checksum="70E24662E13EECA6" modified="2013-03-06" version="1">MSQSILITGATGFVGQYLVKELVKDNCSMSAIIRKAEDKNKLPENVNSFIVNSLNDTLPSDFLQNQEVIIYLAARVHQMNDRTFSSLEAYREINTYAPISLAKQGVKNGVKRFIYLSSIKVNGEGTFKTPYREDDKPNPVDPYGQSKWEAEQELLKLAEKTSLEVVIIRPPLVYGAGVKANFLQLMKIISKGLPLPLGGINNSRSLVYVGNLVDAIITCIDSPQAQNQTFIVSDGEDLSTPELIRCIGKAMNKTPLLLPIPSSLIKIGTKLLGKGEAGDRLLGSLQVDSGKIRKILNWQPPYTVDEGIKMTADWFNEMIKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z223</accession>
    <name>K9Z223_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="4" type="synonym">rpl13</name>
        <name evidence="7" type="ordered locus">Cyan10605_0498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218371.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0498"/>
    <dbReference type="EnsemblBacteria" id="AFZ52640">
        <property type="protein sequence ID" value="AFZ52640"/>
        <property type="gene ID" value="Cyan10605_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0498"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.528"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_3"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="16847" checksum="8000F030D6F6284E" modified="2013-03-06" version="1">MNKTIVPAIDSIEKKWYVVDAENQRLGRLATEIANVLRGKNKASYTPHLDTGDYVIVVNAEKVVVTGRKSEQKLYRRHSGRPGGMKVETFAQLQKRIPERIIEKAVKGMLPKNSLGRSLFTKLKVYTGPNHPHEAQQPETLTVNTIAGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z239</accession>
    <name>K9Z239_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome bd plastoquinol oxidase subunit 2 apoprotein</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218985.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1134"/>
    <dbReference type="EnsemblBacteria" id="AFZ53256">
        <property type="protein sequence ID" value="AFZ53256"/>
        <property type="gene ID" value="Cyan10605_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1134"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1201"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_1_0_3"/>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="333" mass="37074" checksum="F6F57E811E25C876" modified="2013-03-06" version="1">MESLNYLLPLVWFAILALFLFMYVMLDGFDLGVGILSLTSSSEERRSVLMTSLSNVWDANATWLILMGGSLFGSFPLAYSTILNALYIPIMIMILGLVVRTVSFEFRENSRRKLFWNLAFGIGSFVATLGQGFALAGVIEGIHVDASGHFIGSTWDWFNWRSVVVALTLIQGYVLIGSCYLIMKTTGSLQETHYKTAKIAAITTLIGAIAITTVTPIFSIFARNRLFDKPFIYVFSAIPILGVILVILLLRSLAKKREVTPFIYTILIFLLTFVGLALVVFPYIIPPSVTIFDAAASPSSLVFMLTFIGFLIPIMLFYNVYNYFVFRGKITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z251</accession>
    <name>K9Z251_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="7" type="synonym">rpl23</name>
        <name evidence="10" type="ordered locus">Cyan10605_0523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218396.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0523"/>
    <dbReference type="EnsemblBacteria" id="AFZ52665">
        <property type="protein sequence ID" value="AFZ52665"/>
        <property type="gene ID" value="Cyan10605_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0523"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.553"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_0_3"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="112" mass="12761" checksum="0CC5655022B94753" modified="2013-03-06" version="1">MANSRYGKTTKVRKTTAELADIVIRPIVTEKATYMMEDNKYVFEVVKTSTKPEIRAAIESLFDVKVVKVNTMNQPRKQRRVGQNVGYKPQYKKAIVTLAEGDSLQSTFFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z286</accession>
    <name>K9Z286_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218983.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1132"/>
    <dbReference type="EnsemblBacteria" id="AFZ53254">
        <property type="protein sequence ID" value="AFZ53254"/>
        <property type="gene ID" value="Cyan10605_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1132"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1199"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_1_3_3"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="31618" checksum="02C2904E47314954" modified="2013-03-06" version="1">MTKTAWVFPGQGSQTQGMGMDLIEVAQDKFKQAEEILGWSIIQRCQGDEETLSRTLYTQPCLYTIEAILVDLLKDKGKNADFVAGHSLGEYVALYAANVYDFATGLNLVKMRSQFMDQAQGGKMVALMKFNREILEKTIENTENVVLANDNSDGQVVISGEPNAVDEVVEAVKAKLAVPLKVSGAFHSPLMAIAAAEFAKVLDEAEFKDAQIPVLANVDPNPSIDGQEIKERLKQQMTGGVRWREIMAQMPSLGVQEVIEIGPGKVLTGLFKRSVKDVSLVNINGLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B9</accession>
    <name>K9Z2B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219018.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1168"/>
    <dbReference type="EnsemblBacteria" id="AFZ53289">
        <property type="protein sequence ID" value="AFZ53289"/>
        <property type="gene ID" value="Cyan10605_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1168"/>
    <dbReference type="eggNOG" id="ENOG5033SHT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563508_0_0_3"/>
    <dbReference type="OrthoDB" id="2124478at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938643" evidence="4">
        <location>
            <begin position="29"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="55086" checksum="CAA5029D7443DD9F" modified="2013-03-06" version="1" precursor="true">MKNQILKSIILSSLIPSIITNFSYPVFAQSKSNNSPSSPNFQGLLIDIKNSYDNFNDSNQLLLTKLEEESKKNPPTTDIEGVETKIKENYDKLVTSVSNLKNQLSEEEKRELNNLLSPLQTEKEKGLSVEAFTKLLEDGRLDKTEICESIQIPLGLFLSKNDANCGNFNNKTYGKLSGFINTQIEAIDKEIKTVEKLPRFGNNSGETSGQNNSSQEDNSSFLILWIVNLIIALGLIGAFIGIYLLNKKIEKENHKLYNHIEKTENKIEELSERNQNQSKQVTKQDAQIKNLKNKNDSLQKEIENLTSQINNILLKVNPLEKQYSSNQTQPQNEIITDENNELKPELEEQTKSEPEPEYLRLARSYQENPHNLVQNAIRVSMTKETLNKILAGTWEGIVELEENNRQGEFYIINNNSGQFYLFLDPDTKFNVPTLQNINKSQLFICKGNMSQGFKGNEIHIIKPAVVQENNNNWRLAESGEIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2D7</accession>
    <name>K9Z2D7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218628.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0764"/>
    <dbReference type="EnsemblBacteria" id="AFZ52897">
        <property type="protein sequence ID" value="AFZ52897"/>
        <property type="gene ID" value="Cyan10605_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0764"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.804"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017255_0_0_3"/>
    <dbReference type="OMA" id="RQLNWLW"/>
    <dbReference type="OrthoDB" id="912631at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="258"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="620" mass="71143" checksum="49E57F1BF407CE1B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2J5</accession>
    <name>K9Z2J5_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219150.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1306"/>
    <dbReference type="EnsemblBacteria" id="AFZ53421">
        <property type="protein sequence ID" value="AFZ53421"/>
        <property type="gene ID" value="Cyan10605_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1306"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1379"/>
    <dbReference type="eggNOG" id="COG4448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062004_0_0_3"/>
    <dbReference type="OMA" id="DDCGAPT"/>
    <dbReference type="OrthoDB" id="1434447at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="317" mass="34932" checksum="54E2A8E8E60DA28C" modified="2013-03-06" version="1">MTKLKRPSYPRLEIHLLREGIVESIHQAEVVVADDRGRVLAVAGDAETFSFMRSAMKPFQALAVTSTGVIERFDLDDQDLAIICSSHQGTIEQARQVFNILWRADIEPSFLKCPIPAGKNSALQHNCSGKHAGMLATCKQRNWNLDTYYYKSNPIQELILHKIAELLSIPADEIMSARDDCGVPTYALELSQMATLYAKLASGNSIDLERIVRAMTNHPTMVAGEGAFDTELMNLTDGRLVSKSGAEGIQCVGNIGQNMGLAIKVLDGAKRAKYATAIHVLKQMGWITPAVAENLGEMFLRIDDYRRLEVAGELTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2V4</accession>
    <name>K9Z2V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219270.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1430"/>
    <dbReference type="EnsemblBacteria" id="AFZ53541">
        <property type="protein sequence ID" value="AFZ53541"/>
        <property type="gene ID" value="Cyan10605_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1430"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1511"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017738_0_0_3"/>
    <dbReference type="OMA" id="NALFIPY"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="5">
        <location>
            <begin position="423"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="5">
        <location>
            <begin position="564"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="694" mass="75620" checksum="1405239500E361C4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z308</accession>
    <name>K9Z308_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0838"/>
    <dbReference type="EnsemblBacteria" id="AFZ52970">
        <property type="protein sequence ID" value="AFZ52970"/>
        <property type="gene ID" value="Cyan10605_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0838"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.881"/>
    <dbReference type="eggNOG" id="ENOG5032Y9X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201023_0_0_3"/>
    <dbReference type="OMA" id="RPDFVPK"/>
    <dbReference type="OrthoDB" id="1940926at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="7859" checksum="4D60DF5FDACFA703" modified="2013-03-06" version="1">MINHLSLEFLAVAGEFPVYFVAVYVVGFIAAVVIGSIAWYSSKRPVGWEDAEKPKFIPEVKAKENEENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z322</accession>
    <name>K9Z322_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharop_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFZ52985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0853"/>
    <dbReference type="EnsemblBacteria" id="AFZ52985">
        <property type="protein sequence ID" value="AFZ52985"/>
        <property type="gene ID" value="Cyan10605_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0853"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.896"/>
    <dbReference type="eggNOG" id="COG1834">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392230_0_0_3"/>
    <dbReference type="OMA" id="TSLGVDM"/>
    <dbReference type="OrthoDB" id="127899at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHP00300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00300">
        <property type="entry name" value="TIGR00300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharop_dh_N" evidence="1">
        <location>
            <begin position="286"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="705" mass="78461" checksum="A127DBE6BA2418AA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z361</accession>
    <name>K9Z361_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1031"/>
    <dbReference type="EnsemblBacteria" id="AFZ53157">
        <property type="protein sequence ID" value="AFZ53157"/>
        <property type="gene ID" value="Cyan10605_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1031"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1093"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_1_3"/>
    <dbReference type="OMA" id="FPIDQSR"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="15332" checksum="4E6C766F280D828E" modified="2013-03-06" version="1">MSLEVSAMFKNILFPIDQSREAREAVAVVSNIVKTYESKLYLLSVVETNQEEDAVMSDMKTVAQLLKNAQDLFFQAEIIAEVIEREGMPPFVICDVADEIEANLIIMGCRGLGLTQEGVEDSVTNRVINLAPCPVLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z370</accession>
    <name>K9Z370_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0670"/>
    <dbReference type="EnsemblBacteria" id="AFZ52808">
        <property type="protein sequence ID" value="AFZ52808"/>
        <property type="gene ID" value="Cyan10605_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0670"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.706"/>
    <dbReference type="eggNOG" id="COG3329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032027_0_0_3"/>
    <dbReference type="OMA" id="YKFIVFM"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010293">
        <property type="entry name" value="Sbt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40400">
        <property type="entry name" value="PTHR40400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05982">
        <property type="entry name" value="Sbt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="382" mass="40683" checksum="8B3F23DAED3B19C1" modified="2013-03-06" version="1">MRRQKEVFVDFLSNFVSDFIGQLQSPTLGFLIGGMIIAALGSQLQIPDSIYKFIVFMLLIKVGLSGGIAIRKANLGEIFLPALFAVLLGILIVFIARYTLAQLPNIKTVDALATGGLFGAVSGSTLAAGLTALEAQGIEYEAWAAALYPFMDIPALVTAIVMASVYLSKRRNDKEEEFSKVEYVSKQAVAAGDYSSMEYPTTRQEYLSQQRGTPKRVEIWPIVKESLQGSALSALLLGLALGLFTQPESVYESFFNPLFRGLLSILMLIMGMEATARLSELRKVAQWYAVYAFIAPLVHGFIAFGFGMIAHALTGFSLGGVVILAVIACSSSDISGPPTLRAGIPSANPSAYVGSSTAIGTPVAIGIGIPLYIGLAQAIMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3A2</accession>
    <name>K9Z3A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219361.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1525"/>
    <dbReference type="EnsemblBacteria" id="AFZ53634">
        <property type="protein sequence ID" value="AFZ53634"/>
        <property type="gene ID" value="Cyan10605_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1525"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_3"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="27350" checksum="F3F20C6F73FBE881" modified="2013-03-06" version="1">METQKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEDAIATFHETQPDLVVLDVMMPKLDGYGVCQELRKESDIPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRVDKTGVAGIPSSGVISINSIRIDTNKRQVYKGDQRIRLTGMEFSLLELLVSKSGEPFSRSEILQEVWGYTPERHVDTRVVDVHVSRLRAKLEDDPSNPELILTARGTGYLFQRILEPGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3D1</accession>
    <name>K9Z3D1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_0970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218831.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0970"/>
    <dbReference type="EnsemblBacteria" id="AFZ53100">
        <property type="protein sequence ID" value="AFZ53100"/>
        <property type="gene ID" value="Cyan10605_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0970"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1024"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_0_3"/>
    <dbReference type="OMA" id="SFRYAAQ"/>
    <dbReference type="OrthoDB" id="2028997at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01069">
        <property type="entry name" value="DAGK_PROKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ53100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="180" mass="20005" checksum="0FA11750C7838341" modified="2013-03-06" version="1">MPKFQLISNDQPITSKPITSKSDFPQFLAQQPVHHNFSSEKTYHYKSEKRYLAWKVATNLGLSFRYAWQGVKYAFTTQRNFRIHTVMTSVALALGFYLHATTVEMALISLTCAMVMVLELLNTALESVVDLTVKQTYHELAKIAKDCAAGAVLIGSLASLLVAGFILLPHGIDLIISILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3H8</accession>
    <name>K9Z3H8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GUN4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219478.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1645"/>
    <dbReference type="EnsemblBacteria" id="AFZ53751">
        <property type="protein sequence ID" value="AFZ53751"/>
        <property type="gene ID" value="Cyan10605_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1645"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067449_2_1_3"/>
    <dbReference type="OMA" id="WWKSPYG"/>
    <dbReference type="OrthoDB" id="1524839at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16383">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008629">
        <property type="entry name" value="GUN4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037215">
        <property type="entry name" value="GUN4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34800">
        <property type="entry name" value="PTHR34800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05419">
        <property type="entry name" value="GUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140869">
        <property type="entry name" value="SSF140869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GUN4" evidence="2">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="22124" checksum="77DA5D03792E85F6" modified="2013-03-06" version="1">MNDIEVRVQKLETEISRLTNLIEELQEQFILLPDIARYGTLQKFLKNKDFREADIETTRIMLEVAGEQRETLSPEDVSKYPCNSLQVIDQMWYKYSSGKFSFGVQLKNYYEAGGDIDTIRAQDVKVLTKFADKVGWLNENKQPRFSEYDDWDFSLSAPDGCFPAHWWKSPYGLKMVTFFFSRLISCNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I8</accession>
    <name>K9Z3I8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219488.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1655"/>
    <dbReference type="EnsemblBacteria" id="AFZ53761">
        <property type="protein sequence ID" value="AFZ53761"/>
        <property type="gene ID" value="Cyan10605_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1655"/>
    <dbReference type="eggNOG" id="ENOG5031MCC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141604_0_0_3"/>
    <dbReference type="OMA" id="KRVIYAF"/>
    <dbReference type="OrthoDB" id="1920675at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="159" mass="17864" checksum="1EB012CE9C8B4CBB" modified="2013-03-06" version="1">MNLDQQLRNLIQEAPNYGVPAVIMENGVIPIINAFAQQLGHQEYYLRQTLDNNLVLTILGSDQHPELEKKVIYAFPSVQSAAQFPDSKIDSPDIVAQQVPVSQILFQMFTMKGVDSVIFVDEPNQYQQSKEVYCDKLQSAIRQNLSNLINSATSPNRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3M5</accession>
    <name>K9Z3M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">REG-2-like, HAD superfamily (Subfamily IA) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219456.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1622"/>
    <dbReference type="EnsemblBacteria" id="AFZ53729">
        <property type="protein sequence ID" value="AFZ53729"/>
        <property type="gene ID" value="Cyan10605_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1622"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1722"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_3"/>
    <dbReference type="OMA" id="CDYQGAR"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="215" mass="25161" checksum="1883E79F68E29DE3" modified="2013-03-06" version="1">MNQPKVIFLDAVGTIFGVKNSVGDAYIKISSQYGVIRNCQEINQYFYECFKSSPPLAFKTQNKQEIQQLEYQWWEKIAYDTFAKANALGEFTDFKAFFAQLYDYFTTAEPWFIYDEVVSCLKKWQNQDIQLAMISNFDTRIYDVLKNLNLATYFQTITISSLTGVAKPHPQIFLKALEKHDCQPQEAWYIGDSKQEDYWGAKSVGMQSFWLNRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z408</accession>
    <name>K9Z408_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218844.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0983"/>
    <dbReference type="EnsemblBacteria" id="AFZ53113">
        <property type="protein sequence ID" value="AFZ53113"/>
        <property type="gene ID" value="Cyan10605_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0983"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1038"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_0_1_3"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="35"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="243" mass="26401" checksum="03756DEFC0A62C00" modified="2013-03-06" version="1">MLESFSNQLYYLQQFANELVNNQLHQVSIFSFLIIFVTGLITSLTPCMLSMLPLTIAYIGGYETKGRLSSFLQSAYFALGLATTLTLLGVFAALLGRVYGQIGTGLPIFVSAIAILMGLNLLEIVPLKFPNWDASNWVKDNFPNSLKSYLLGLTFGLIASPCSTPVLITLLAFVASSENIFLSSLLLVSYAIGYVFPLILAGTFTGTLKSLLNLRVITQWINPISGGILLIFGIYSLGSYLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z413</accession>
    <name>K9Z413_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219039.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1191"/>
    <dbReference type="EnsemblBacteria" id="AFZ53310">
        <property type="protein sequence ID" value="AFZ53310"/>
        <property type="gene ID" value="Cyan10605_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1191"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1256"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059313_0_0_3"/>
    <dbReference type="OMA" id="PIGGEFW"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="328" mass="38891" checksum="A1AE42D338A1932E" modified="2013-03-06" version="1">MKPIGGYFELELNQQQKNWHPNANLTLKSGRSCLQFLIKSQSLKQVFIPYYTCDALIEPLENYNVNYSFYELNEKLEIKADNLVVNPNDILIYINYFGLKNKYLETLVKKHNKQLWVDNTQSFFYQPKMKTSVYFNSARKFFGVPDGAYLYTPDNIYLSSLNNLKRNQNYRCEHLLLRHQGILEEGYKIFQDNEKLNGDEIALISELSEIILSQIDYNDVAQKRCQNYLYLDQILGSHNQLSSEVIKLDNNSIPFCYPYLPVKSIKHEYFWEKLIFVPILWRECVNRITEGFEWEKHLTSQLLPLPIDQRYSFEEMDLIIKAIMDYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z428</accession>
    <name>K9Z428_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218864.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1004"/>
    <dbReference type="EnsemblBacteria" id="AFZ53133">
        <property type="protein sequence ID" value="AFZ53133"/>
        <property type="gene ID" value="Cyan10605_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1004"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1061"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_2_1_3"/>
    <dbReference type="OMA" id="WFIGDIL"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="181" mass="20501" checksum="899C30C532F73FCD" modified="2013-03-06" version="1">MKALFLDRDGVVIDYIPYLSKPEQVKIPENAPFALKQWQNQGYRLVIVTNQSGISRGYFTLEEVKAIHERLIAEYANFGVYFADILICPHQPADKCLCRKPSPFLIKTYAENHGIDLSQSYFIGDAPSDIECAINAKCQPVLLLTGRGKETLTHLSQYSLSIPVFEQMKDTILLLKTFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z432</accession>
    <name>K9Z432_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ordered locus">Cyan10605_1792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219621.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1792"/>
    <dbReference type="EnsemblBacteria" id="AFZ53894">
        <property type="protein sequence ID" value="AFZ53894"/>
        <property type="gene ID" value="Cyan10605_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1792"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1900"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_1_1_3"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="115"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="313"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="450" mass="48915" checksum="2932152EE10F72DF" modified="2013-03-06" version="1">MKTFANVDFIREITEAKCSSFSSQILAENCLGISTDTRTLKRGEIFLALEGENFNGHDFLDNAFEKGAIASIVNEKYSNLINKNSPILQVKNTLEAYQKIAQWWRQNLGLPVIGVTGSVGKTTTKELISAVLKTQGKVLKTEANYNNEIGVPKTLLQIDETDNYAVIEMAMRGKGQIALLTEIAQPNIGVITNVGTAHIGLLGSREAIAEAKCELLANMDNSGVAIINGDNDLLVATATKVWTGETITYGLKSGNFRGELINDSTLKVDNQLYPLPLLGEHNALNYLGAIATAKVLGLDLTLLQQGIEVNLPKGRAKRYSLPNDILVLDETYNAGYESMLASLKLLAQTDGKRKIAVLGTMKELGDYAPILHRQVGETIKELNLDLVLILADEEATKQIAEGANGIPSQIYSNHKDLISALQNITKEGDRILFKASNSVGLSKVVEVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z434</accession>
    <name>K9Z434_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ordered locus">Cyan10605_1009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218869.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1009"/>
    <dbReference type="EnsemblBacteria" id="AFZ53138">
        <property type="protein sequence ID" value="AFZ53138"/>
        <property type="gene ID" value="Cyan10605_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1009"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1067"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_2_3"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="192" mass="22081" checksum="15E71900737BDA42" modified="2013-03-06" version="1">MKLLIQGNNIEVTESIHDYVEEKLEKAVKHFQNLATKVDVHLSVARNARISNKHKAEVTVYANGTIIRAQEHSENLYASIDLVSDKITRQLRKYKERNLAKKTHTAEKTSDAVEEKTVGTDLIGDREPELPSEVVRMKYFAMTPMTIDQALEQLQLVDHDFYMFRNEETGEINVIYQRNHGGYGVIQPRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z435</accession>
    <name>K9Z435_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein HSR1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1855"/>
    <dbReference type="EnsemblBacteria" id="AFZ53956">
        <property type="protein sequence ID" value="AFZ53956"/>
        <property type="gene ID" value="Cyan10605_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1855"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345718_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="320"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="817" mass="95009" checksum="B901696B51924AD9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z451</accession>
    <name>K9Z451_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1236</name>
        <name evidence="4" type="ordered locus">Cyan10605_1874</name>
        <name evidence="5" type="ordered locus">Cyan10605_3530</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of plasmid of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
            <plasmid evidence="5">pCYAN10605.01</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
            <plasmid evidence="6">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1236"/>
    <dbReference type="EnsemblBacteria" id="AFZ53355">
        <property type="protein sequence ID" value="AFZ53355"/>
        <property type="gene ID" value="Cyan10605_1236"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53974">
        <property type="protein sequence ID" value="AFZ53974"/>
        <property type="gene ID" value="Cyan10605_1874"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55563">
        <property type="protein sequence ID" value="AFZ55563"/>
        <property type="gene ID" value="Cyan10605_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1236"/>
    <dbReference type="KEGG" id="can:Cyan10605_1874"/>
    <dbReference type="KEGG" id="can:Cyan10605_3530"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1304"/>
    <dbReference type="HOGENOM" id="CLU_056788_6_0_3"/>
    <dbReference type="OMA" id="PEMNPID"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="170" mass="20390" checksum="D3BB4080D385B06C" modified="2013-03-06" version="1">MWAEDEHRLGLKPVLRRVWVEKGYQPIATVNWRFQWLWLYGFVEPNTGETYWWLLPYVNTELFNRVLKDFAQHYEIGKNKRVILAMDQAGWHPIKETTEIPEGIHVMLMPSHSPELQPAERLWPLINEAIANRTFKNLEELEEVVISRCKKIMEEKEIVKGIANFYWWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z499</accession>
    <name>K9Z499_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer DM13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219301.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1461"/>
    <dbReference type="EnsemblBacteria" id="AFZ53572">
        <property type="protein sequence ID" value="AFZ53572"/>
        <property type="gene ID" value="Cyan10605_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1461"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1549"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089192_0_0_3"/>
    <dbReference type="OMA" id="AGWHVFD"/>
    <dbReference type="OrthoDB" id="1551664at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="160" mass="17715" checksum="43722B22E61828E5" modified="2013-03-06" version="1" precursor="true">MKRTAIIAFSVVPAIVAMMLPDVCAMIKPTQRLSNHIDTSGQLIAMKMPMFVSGEHPTSGSVSVVREGENKYIEFGEDFKTDSGPDLFVILHKNKDVIGTTKAPTHSIKEGDYVTLEPLKKVKGKQRYKIPSEVNLENYKSVAIWCRQFNATFGAATLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4A7</accession>
    <name>K9Z4A7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219306.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1466"/>
    <dbReference type="EnsemblBacteria" id="AFZ53577">
        <property type="protein sequence ID" value="AFZ53577"/>
        <property type="gene ID" value="Cyan10605_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1466"/>
    <dbReference type="HOGENOM" id="CLU_2245468_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="104" mass="11953" checksum="E1DF64645764EC51" modified="2013-03-06" version="1">MKQKKDDSPLDIILDAIFDLFKAAFGKKKENKPSQYFLYGFLFLIIALAINYFFSIFLGIFTVQENLNSSLNNILSLLKIIIWIINAIFIGSGLMCFYRGLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4G7</accession>
    <name>K9Z4G7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin reductase domain protein FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mediates electron transfer from NADH to oxygen, reducing it to water. This modular protein has 3 redox cofactors, in other organisms the same activity requires 2 or 3 proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the flavodoxin reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219759.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1938"/>
    <dbReference type="EnsemblBacteria" id="AFZ54034">
        <property type="protein sequence ID" value="AFZ54034"/>
        <property type="gene ID" value="Cyan10605_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1938"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2059"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_2_1_3"/>
    <dbReference type="OMA" id="AFGLHYC"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="266"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="573" mass="63953" checksum="4554FC7DDEE718D2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4H1</accession>
    <name>K9Z4H1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic-acid-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219214.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1372"/>
    <dbReference type="EnsemblBacteria" id="AFZ53485">
        <property type="protein sequence ID" value="AFZ53485"/>
        <property type="gene ID" value="Cyan10605_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1372"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1449"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_3"/>
    <dbReference type="OMA" id="AVDAEFM"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ53485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="256" mass="28804" checksum="35DC8A6B760FF7AD" modified="2013-03-06" version="1">MTQEVIRLDQVSLWRRTQEEFSYDLKRTIFSFLQGKHIKPAKKQVLQDVDFSVSAGEKVGIIGSNGAGKSTLLKVICGILPPTEGSVRVRGRIAPLIELGAGFNMEMSVQDNIILYGVLLGYRKEDMKVRIREILEFAELEDYAEIPVKALSSGMKARLGFSVATDVEPDILILDEVLSVGDARFTQKSRQRIQDLWEKSSTILFVSHSLDYVQDLCDRSIWLNKGQVAFAGDTEEAIKRYLDYVGIKEYIAPPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K5</accession>
    <name>K9Z4K5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c biogenesis protein CcsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccsA</name>
        <name evidence="8" type="ordered locus">Cyan10605_1403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">May interact with Ccs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cellular thylakoid membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219244.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1403"/>
    <dbReference type="EnsemblBacteria" id="AFZ53515">
        <property type="protein sequence ID" value="AFZ53515"/>
        <property type="gene ID" value="Cyan10605_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1403"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1482"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_3"/>
    <dbReference type="OMA" id="WLVMHVS"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01391">
        <property type="entry name" value="CytC_CcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="68"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="328" mass="35969" checksum="AEA76C3DBAD7AE4A" modified="2013-03-06" version="1" precursor="true">MDLVSLENILDNVSFAVLFITMLFYWVGTAFPNFSILPKLGTMGMIIGNLSIASLLLARWIEGGYFPISNLYESLFFLGWGVTTVHLIAESMSGSRLVGVVSAPTAMGIAAFATLSLPPEMQHSEPLVPALKSNWLMMHVSVMMFSYSALMVGSLVAIAFLILTQGKEIQLRGSSVGTGAYRNVKALKLNYQGEKITEVENQGGTAVLTQEKTIVNQLSPERLSLVDTLDNISYRIIGLGFPLLTIGIVSGAVWANEAWGSYWSWDPKETWALITWLVFAAYLHARITKGWQGRKPALLAAGGFLVVWICYLGVNLLGKGLHSYGWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4K6</accession>
    <name>K9Z4K6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_1558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1558"/>
    <dbReference type="EnsemblBacteria" id="AFZ53667">
        <property type="protein sequence ID" value="AFZ53667"/>
        <property type="gene ID" value="Cyan10605_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1558"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1655"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065784_2_0_3"/>
    <dbReference type="OMA" id="WVASADC"/>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ53667.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="255" mass="28462" checksum="1AB7DB61953EC146" modified="2013-03-06" version="1">MWQWRETEKGRFLTCDLLRNWQHGFFTCHFQGDSPDILVSYLNPNASVYRLKQIHSDILFSTATLDSHYLSGADLLEGDGIISSKSLDSVWCASADCTPVLIADKGTGGVMAIHSGWRGTSTAIVPKAIALLQSQGAKLEDLLFALGPAIHGKVYQVNEEVAVEVLKTIFPSDTPSELIIEKALQIENQPILPDEEENKVRLNVTQVISLQIQQQGINLNQIAIAPYCTYQTPEDFFSYRRTKEKKIQWSGIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4L1</accession>
    <name>K9Z4L1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1209"/>
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        <property type="protein sequence ID" value="AFZ53328"/>
        <property type="gene ID" value="Cyan10605_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1209"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1276"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022025_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="237"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_41" evidence="1">
        <location>
            <begin position="416"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="617" mass="72424" checksum="4148DF31723B45E9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N4</accession>
    <name>K9Z4N4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ordered locus">Cyan10605_1568</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">In cyanobacteria the RNAP catalytic core is composed of 2 alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219404.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1568"/>
    <dbReference type="EnsemblBacteria" id="AFZ53677">
        <property type="protein sequence ID" value="AFZ53677"/>
        <property type="gene ID" value="Cyan10605_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1568"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1665"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_3"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="365"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="443"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="572"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ53677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122449" checksum="A538B806C3A85E26" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N6</accession>
    <name>K9Z4N6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease YjgP/YjgQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219092.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1245"/>
    <dbReference type="EnsemblBacteria" id="AFZ53363">
        <property type="protein sequence ID" value="AFZ53363"/>
        <property type="gene ID" value="Cyan10605_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1245"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1313"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_1_3"/>
    <dbReference type="OMA" id="FISSQWL"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ53363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="378" mass="42776" checksum="5F321AC9D418E0FB" modified="2013-03-06" version="1">MRPFKFSILDSYLFQELIPPFIFSVAIFSTLGVAIATLSDLSYKIVNANLPFIYALQIFFLKIPEYVAYALPISVLLTTLMTYSRLSKDSELIAFYNCGLSLYRLITPALILSLIVTGLTFIFNELIVPNANYKATTILVEQINEQRKFLLRQDIFYPEYVNVKEKNGKNNKYLKTLFYAQEFDGENMQSLTILDTEKKGLNKVIISEKGTWNNQDKVWDLFNGFIYDITKNQIKAEGKFFEKTQISLPKTPLELASKSRDPYEMNIIQSLEYIKLLRLLGDDKTVLMFQVRTAQKISFPFVCVIFGLVGSSLGSRPNNASKATSFGLCVGIVFFYYLGSFMISSLGLIGIISPLMAAWIPNFIGLLIGGFLLAKENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4N8</accession>
    <name>K9Z4N8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">Cyan10605_1439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219279.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1439"/>
    <dbReference type="EnsemblBacteria" id="AFZ53550">
        <property type="protein sequence ID" value="AFZ53550"/>
        <property type="gene ID" value="Cyan10605_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1439"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_3_0_3"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15218" checksum="33DDB1B7F6D2CA43" modified="2013-03-06" version="1">MVKNPQIRIPIIISLGAIAGVLCRYYIGLWLLQNFKTQFPIDIFLINISGCFFMGFLSTILARKYPLHPELVLLLITGFLGTYTTFSTYELNTAVNLNNLSRDLLYWIGSPILGLFCLEIGIKLAQITLSIKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4P0</accession>
    <name>K9Z4P0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219097.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1250"/>
    <dbReference type="EnsemblBacteria" id="AFZ53368">
        <property type="protein sequence ID" value="AFZ53368"/>
        <property type="gene ID" value="Cyan10605_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1250"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1318"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_7_2_3"/>
    <dbReference type="OMA" id="YNAKQQL"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028351">
        <property type="entry name" value="CyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001892">
        <property type="entry name" value="CyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939103" evidence="4">
        <location>
            <begin position="26"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="484" mass="54271" checksum="E75CBA0005B42CF2" modified="2013-03-06" version="1" precursor="true">MYSKKRSSLLLTTYLLLSCVTPSQAQDVETNTSPQNPSSAQVQSTDKFNSSGNPLLFPTKTQEVEIEEQQPVTLNQAIEIALNNNKDLEVARLQLDRSRDSLNASLATQLPTLNGQLEFNQRGDDTPGEDDFIMRDRSLLLGQIELSYNVYDGGRRNANIARSSREVYLNQLEVERISEDVRFRATNAYYELQNADAQVAIAQAAIEDFSQTLRDAQLLEQAGLGTRFDVLQAEVDLANANQALTRAIAEQRNARRNLAQVLSVGQNVELTAADEIQENGEWPYDLEQSIIMAYKNRAELQQLLVQREINEQDREIALAATRPTVNLFANYNFTNTFTDTFDSTGYANGYNVGARLNWEIFDGGEASARADVETRNIEIDETNFAKQRDEIRLNIETAYNNMIANKENISTTETAVTTAVESLRLARLRFQAGVGTQTDVINAQRSLTEARGNFLQAIIGYNQSLNELQRAVSNLPDNKLFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X8</accession>
    <name>K9Z4X8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdxJ</name>
        <name evidence="3" type="ordered locus">Cyan10605_2133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219946.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2133"/>
    <dbReference type="EnsemblBacteria" id="AFZ54221">
        <property type="protein sequence ID" value="AFZ54221"/>
        <property type="gene ID" value="Cyan10605_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2133"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2268"/>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074563_0_0_3"/>
    <dbReference type="OMA" id="SNAGWDT"/>
    <dbReference type="OrthoDB" id="1159993at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="1-deoxy-D-xylulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="240" mass="26583" checksum="81AA1F26369C0FB3" modified="2013-03-06" version="1">MLTLGVNIDHVATIRQARRTVEPDPVAAAVLAELGGADGITTHLREDRRHIQDRDVRILRETVRTHLNLEMAPTEEMVAIALSLKPDYVTLVPEKREEVTTEGGIDIVNNLEKFTAIVDKMQSADIPVSWFIDADEAQIEAAAKTKAIFIELHTGKYADAENESTRQQELSALKKGTKQALELGLRVNAGHGLTYWNVYPVACIEGMEELNIGHSIISRAVLVGLERAVKEMKLAMKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4Z0</accession>
    <name>K9Z4Z0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2281 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219372.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1536"/>
    <dbReference type="EnsemblBacteria" id="AFZ53645">
        <property type="protein sequence ID" value="AFZ53645"/>
        <property type="gene ID" value="Cyan10605_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1536"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1631"/>
    <dbReference type="HOGENOM" id="CLU_198141_0_0_3"/>
    <dbReference type="OrthoDB" id="2045566at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018739">
        <property type="entry name" value="DUF2281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10047">
        <property type="entry name" value="DUF2281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2281" evidence="1">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="77" mass="8883" checksum="55F1808E49EC9F87" modified="2013-03-06" version="1">MTLEQLLISKFQTLSPHRKQELLDFAEFLAQKSDSQSQGKLSNNKTTIRGLWKDVVVTDEDLDEAKKAVFKNISEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z535</accession>
    <name>K9Z535_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219969.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2158"/>
    <dbReference type="EnsemblBacteria" id="AFZ54244">
        <property type="protein sequence ID" value="AFZ54244"/>
        <property type="gene ID" value="Cyan10605_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2158"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2293"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_2_3"/>
    <dbReference type="OMA" id="WAGELSK"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="178" mass="20422" checksum="D12F5A3A6A8D046C" modified="2013-03-06" version="1">MSVRLYVKLPKAEIEKEGLEKMFSDFEPSFTTKLIKERKKKECRGFGFVTVPSDEAAEDFINRYNEKPLVYNGETYKDEEGKDFLLVIEKALPRNKGSKEEGEQQEEAETTNNNQVEANTDNKPSRRNNNNKKPKKNRKGGKAKTQKAVSVSESIQPDPRWANELNKLKEMFAAQTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z557</accession>
    <name>K9Z557_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219999.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2188"/>
    <dbReference type="EnsemblBacteria" id="AFZ54274">
        <property type="protein sequence ID" value="AFZ54274"/>
        <property type="gene ID" value="Cyan10605_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2188"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2324"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_3"/>
    <dbReference type="OMA" id="EFLMPYE"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="185"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="539" mass="61589" checksum="4A5B8DD2643910CC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z581</accession>
    <name>K9Z581_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chloramphenicol O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219432.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1597"/>
    <dbReference type="EnsemblBacteria" id="AFZ53705">
        <property type="protein sequence ID" value="AFZ53705"/>
        <property type="gene ID" value="Cyan10605_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1597"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1696"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_5_3_3"/>
    <dbReference type="OMA" id="HRMDGPS"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031470">
        <property type="term" value="C:carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043886">
        <property type="term" value="F:structural constituent of carboxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="210" mass="24062" checksum="922F3AD52BC4DC80" modified="2013-03-06" version="1">MTYPNPEQIYPLTNYSRLCFLKNIVKNPNIIVGDFTYYDDFENPLNFEKNVLYHFDFIGDKLIIGKFCAIASNVKFIMNGANHPLNNFTTYPFAIFGNGWEDKMSVEATSKGDTIIGNDVWLGYNTTIMPGVKIGDGVIVATNSMVTKDIPAYHIVGGNPAQIIRKRFDDEIINFLLELKWWDWTLEKITKYIPVLCSNNIQELKKIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z582</accession>
    <name>K9Z582_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220065.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2256"/>
    <dbReference type="EnsemblBacteria" id="AFZ54341">
        <property type="protein sequence ID" value="AFZ54341"/>
        <property type="gene ID" value="Cyan10605_2256"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2256"/>
    <dbReference type="eggNOG" id="ENOG50335QJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203225_0_0_3"/>
    <dbReference type="OMA" id="HEDEVIC"/>
    <dbReference type="OrthoDB" id="1959622at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8293" checksum="E130F2051C2D3016" modified="2013-03-06" version="1">MAEVRQVKVFYDSMGDSLVVWFDNPENEYEVEETGNEVILMKDKNGKVIGFEKLNFFSQNKSLPIAFETLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5P3</accession>
    <name>K9Z5P3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_1967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219787.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1967"/>
    <dbReference type="EnsemblBacteria" id="AFZ54062">
        <property type="protein sequence ID" value="AFZ54062"/>
        <property type="gene ID" value="Cyan10605_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1967"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591495_0_0_3"/>
    <dbReference type="OMA" id="GRSPDCQ"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="462" mass="52456" checksum="34949F64BD3B13B1" modified="2013-03-06" version="1">MDNYSPAHVTLINSKLKEKVEYILSSQSLNLMGRSPDCQVVLDPQEYITVSRYHAQIQLIEKDDNFSWQIEDKGTTNGTFINGEKIVSPYTLKSGDRILLGLKGPEFIFTTEILNPTVLVEDSPSEINQDKDKLENQDINTETLKEDITNKKTNKEKIVTNKIEKEEENNQNLPQEKRTDKPKIEKEKINLDTYLKPISISEKSLFNLLNFQDIATLEIDSKEVQCCVFNPQNQLIAIALSNKNIEIWEWQTKTRILTLENAHRISVNSLNFSHDSKKLISGGSDKIVKIWDIENQVEIASLSGHKMAINTLCFSQDDKLLASSGSDKIIKIWNVENQAEIASLSGHKMAVNSLYFSNDNHYLISGGGDKLIKIWNIEKQEEEKNIKMENKSPIQSLTFSPDNKLIICLLQDGKICIYDREKETELITLTSPDIWGELIAINQNGNLFISKSPDKGIVIGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5X1</accession>
    <name>K9Z5X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1870"/>
    <dbReference type="EnsemblBacteria" id="AFZ53970">
        <property type="protein sequence ID" value="AFZ53970"/>
        <property type="gene ID" value="Cyan10605_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1870"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039153_0_0_3"/>
    <dbReference type="OMA" id="RVGEIAW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="396" mass="46156" checksum="D98335AED92D9805" modified="2013-03-06" version="1" precursor="true">MKLLRYFFLKQLSFFFWLTLLFNPHISVAQEIKKPNPLTTNFSSDLIPSIDREITPFEKKRIRNRIDELNNLAGAELSQGNDDDAFSAWYEAINLSRYLGIEAEIKMINQVGKVAWDKSRNQDINFLTERLNIIESQATENKELDEDFLAILIDAHEVLHNIDQSITLNQSNLEIARNNNDTDQIKSSLEKLGNLYLAKFDYYSAEPIFKELLEIARQNEDYLGEGIYLRKLAEISQALVNPANSVKYKEELVENGLQNQNLASLAMLKIAIGDDYKSLNDPQSASQSYQEAFNTAWSNQQYAIAGDALKKLGKLYQEYEQWDSALQIYQELIKIEQQSYNLYGLMNTYDYMAIIYQQKEEENQALQYWQKALEIARHLNYKEDYFFNKISRVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z661</accession>
    <name>K9Z661_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1791"/>
    <dbReference type="EnsemblBacteria" id="AFZ53893">
        <property type="protein sequence ID" value="AFZ53893"/>
        <property type="gene ID" value="Cyan10605_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1791"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1899"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629843_0_0_3"/>
    <dbReference type="OMA" id="RYPYLYD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="438" mass="51488" checksum="1938154C6282259A" modified="2013-03-06" version="1">MNINSLSKRQYNNIIGDEQYLYDHLLECVKTKSPQQVLDRFRHLFIQARNYDDQKVLEVLAKLIATKRAELNFPSVLNRCCHILINMWQLNPKTQPFIVELVELFNYLPSGVGIGKSYSSRMVQLVRHFLTTDYYKQIQRLAVIIGENQGRKNNLIPTKPKQETVGNLITRYPYLYDHCLLSVDSSSEQQQTVYQVKNQLEKKFETELSQFVTYQIRVAQAGREKMAQQERERIIKPVTNPTLLSDRDLGRSLKHYVGPVENGYSYQDLSRSFLTHTSDVRNYQLFKDDLYEYIIQSVDGKYGKHSFNKRLYDKMQDLYPKYNQTKPDEFLKMRTYSQVFNYLIVESPQNPNHLVFMDMISNMGTTKTIGLMLKLVLVCSKVKPYLEKRFSILFNHYESFTREGAGWLVRSLEKVHVAFSVNFGNVDMSFLRRIYAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6B5</accession>
    <name>K9Z6B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54669">
        <property type="protein sequence ID" value="AFZ54669"/>
        <property type="gene ID" value="Cyan10605_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2594"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2755"/>
    <dbReference type="HOGENOM" id="CLU_129874_0_3_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="97" mass="10885" checksum="5279A7009E06B391" modified="2013-03-06" version="1">MIELKSYRDLTVWQKSMDLVVICYQLTSLFPKTEIYGLSSQIQRAAVSIPANIAEGKGRNHLGDYIRHLSMANSSLKELETHLMIVGRLGYLNLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6G6</accession>
    <name>K9Z6G6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219723.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1900"/>
    <dbReference type="EnsemblBacteria" id="AFZ53998">
        <property type="protein sequence ID" value="AFZ53998"/>
        <property type="gene ID" value="Cyan10605_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1900"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2016"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250835_0_0_3"/>
    <dbReference type="OMA" id="HIHINDY"/>
    <dbReference type="OrthoDB" id="132031at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="663"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1629" mass="178709" checksum="6BFD87E64A0BB8F4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6J6</accession>
    <name>K9Z6J6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219753.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1932"/>
    <dbReference type="EnsemblBacteria" id="AFZ54028">
        <property type="protein sequence ID" value="AFZ54028"/>
        <property type="gene ID" value="Cyan10605_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1932"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_83_3"/>
    <dbReference type="OMA" id="YICADER"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="195"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="420" mass="48808" checksum="35A55E412FCDC05A" modified="2013-03-06" version="1">MSYNIVVEDNDVIDNNQNLDKNNSLLFLLETAENLEDFCNSCVNFISELIEVKNIIVCQQLAENEDEIEIIYDRILMGERENKLEVIKKRIKDELILNSNYSCYSNFPKNEVQKNRENIYIIPLIFKKYHLGYLYIETESNKKFLKNKIKEIDTIAKYITLYLYNQTLEEKQETLKKEEERLKENHRNQSQYISHMNHELRTPIAAVIGFAKMLQQRLYGDLNPKQAQYIDAIYQSGTYLLELISDLLDISKIQAEKEELFIEQILVYELCESSLALIKTKADEKNLNLNLEISSDISYCFADQRRIKQILVNLLSNAVKFTEKGSVTLEVTKEKNNLIFQIIDTGIGIDKESQSKLFKPFSQLQTHLQKKHRGSGLGLVISRELARLHGGDITLTSEKNQGSCFTFYLPMNLKPSVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6K0</accession>
    <name>K9Z6K0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem II protein PsbQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220539.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2747"/>
    <dbReference type="EnsemblBacteria" id="AFZ54816">
        <property type="protein sequence ID" value="AFZ54816"/>
        <property type="gene ID" value="Cyan10605_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2747"/>
    <dbReference type="eggNOG" id="ENOG5032TF7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118956_0_0_3"/>
    <dbReference type="OMA" id="REMLYIN"/>
    <dbReference type="OrthoDB" id="1763867at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009579">
        <property type="term" value="C:thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023222">
        <property type="entry name" value="PsbQ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017487">
        <property type="entry name" value="PSII_PsbQ_cyanobac"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101112">
        <property type="entry name" value="SSF101112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03042">
        <property type="entry name" value="PS_II_psbQ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0793">Thylakoid</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003939134" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="16889" checksum="1672B2F9EE587C89" modified="2013-03-06" version="1" precursor="true">MKNLFRPLLCLILVFTTTLLVSCGSPTKAKIPTVYTPEKIAQLEEYRTPIAEARAQMSTLQELINAENWVDTRTFIHGPLGELRQNMAIVARKLLPKDQKPAQQIARDLFGHFERIDAAAKDRNSVSAKNEFSEAIKDFDAYLNLVPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6L5</accession>
    <name>K9Z6L5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220116.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2308"/>
    <dbReference type="REBASE" id="58400">
        <property type="entry name" value="Cap10605ORF2308P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54392">
        <property type="protein sequence ID" value="AFZ54392"/>
        <property type="gene ID" value="Cyan10605_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2308"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2452"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005831_3_0_3"/>
    <dbReference type="OMA" id="FFAEDTD"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF53335"/>
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        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1171" mass="134259" checksum="E945377A15A16B7D" modified="2013-03-06" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
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                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
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                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
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                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2189"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5033D0Q">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="45" mass="5356" checksum="8D4D472207651696" modified="2013-03-06" version="1">MEQVDKILEKLKEWTQKVIEALFGPESQPEAELIPIPVKDYPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U2</accession>
    <name>K9Z6U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Cyan10605_2019</name>
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    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFZ54113">
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        <property type="gene ID" value="Cyan10605_2019"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="434" mass="50885" checksum="4A1B71D3EF6CF5BE" modified="2013-03-06" version="1">MVSISKKDLFQAKLTGNLINLENQLQNYFTNSNNLSDFTQDETKNNLHTLTKIYLYQRKYDEAKQLINSILEAKITLLGEENHEVVFILENLAFITYLETYYPFFQDATEAKKLYLKLLAIQKQLYGQNSLKIVQTLIVIGVISTQQEAPAFLAQALHICDSTLTDNDIELAYFLWQIGSALFDKCYFFGAESSELEYIEVVLTESLEICQKYLPESHPLFISCMINLAEAKHHLTHYESAEKLLRKSLAEYEKRFYPFHPQIFNLRYNLIVNLQMQSKHEELVELKKIQDNYREYHEKRIKGIVFSVPDVDTTLYPIEDILTEEDQELDFDFANEYQKMIEKQREYLSQDNFYVANSLENSAYENLRKSELFLLNEVETLFLRALQIKGKILGHNHDEVLDILASLAYVYELQQDQDSYELCSQEIAKLKMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6V7</accession>
    <name>K9Z6V7_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">KaiB domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_2860</name>
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        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
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                <person name="Laurent T."/>
                <person name="Goodwin L."/>
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                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2860"/>
    <dbReference type="EnsemblBacteria" id="AFZ54926">
        <property type="protein sequence ID" value="AFZ54926"/>
        <property type="gene ID" value="Cyan10605_2860"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.3040"/>
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    </dbReference>
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        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="91" mass="10429" checksum="4D3EFD08C80919EC" modified="2013-03-06" version="1">MSNYLLRLYITGNSLNSQRAIANLLKLCREELNNKYQVEIIDVLEEPARAEREKILVTPTLIKQLPPPLQRIIGDLSNRENVICGLDLIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6X1</accession>
    <name>K9Z6X1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
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    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="33" mass="3929" checksum="A7064FCF3349723C" modified="2013-03-06" version="1">MLNQIINTDKKIVYMYVKILLVSILNNYIDKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y3</accession>
    <name>K9Z6Y3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220226.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2420"/>
    <dbReference type="EnsemblBacteria" id="AFZ54502">
        <property type="protein sequence ID" value="AFZ54502"/>
        <property type="gene ID" value="Cyan10605_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2420"/>
    <dbReference type="eggNOG" id="ENOG50347AK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034186_0_0_3"/>
    <dbReference type="OMA" id="WVKAIKN"/>
    <dbReference type="OrthoDB" id="2156426at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="121" mass="13343" checksum="F4E3E8A4944143D8" modified="2013-03-06" version="1">MVLNKLFGKKKDNYFFEAENKSTNETETQVEGNQTETTPSEGDAETNATPAVSAPQKDVAYEVPDWVKAIKNYSSQDTSNNAQSQGENYAGKYVTNNVPFSRRRPGPSLKPFKGMASKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z793</accession>
    <name>K9Z793_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ordered locus">Cyan10605_2152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2152"/>
    <dbReference type="EnsemblBacteria" id="AFZ54238">
        <property type="protein sequence ID" value="AFZ54238"/>
        <property type="gene ID" value="Cyan10605_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2152"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2286"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_3"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="408" mass="44930" checksum="01D9C16E39F84318" modified="2013-03-06" version="1">MLGNVNYMSRANKVVLAYSGGVDTSVCIPYLKNEWGVKEVITLAADLGQGEELAPIQEKALKCGAVESLVENATEEFVTNYAFPAIKANALYENRYPLSTALARPLIAKLLVEAAEKYGADAVAHGCTGKGNDQVRFDLGITALNPNLKILAPAREWGMSREETIAYGEKFGIESPVKKSSPYSIDRNLLGRSIEAGPLEDPMTEPPEEIYALTKSITDAPNEPQYVEITFEKGIPVAVDGEALSPVALITKLNEIAGNHGVGRLDMIENRVVGIKSREIYEAPALLVLIKAHEDLESLTLTSDVTHYKRAQIDLMYTRLVYEGLWYSPLKSALDAFIDQTQDRVSGVVRIKFFKGNATIVGRKSHYSLYSPDLSTYGSDDKFDHKAAEGFIYIWGLSSRVWAEKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z794</accession>
    <name>K9Z794_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2952"/>
    <dbReference type="EnsemblBacteria" id="AFZ55014">
        <property type="protein sequence ID" value="AFZ55014"/>
        <property type="gene ID" value="Cyan10605_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2952"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3141"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_5_1_3"/>
    <dbReference type="OMA" id="IIWVADL"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="178" mass="19906" checksum="7B784F47D46B19B5" modified="2013-03-06" version="1">MAENQYYPEVVNNNVPLGAEQTVEQVEAPEGELHLRFVLPSGDEFALSAVGIREVMQQESERITSVPNASPLLLGTINLRGEIIWVADLGQFLGYPNILNTDRAEIPVIAVEEQETILGLAVDKLGAMEWIDVDTLQLPQNLPDHIAPYIQGEWIDDKNKRIRLLDQIAILRSARWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7A2</accession>
    <name>K9Z7A2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ordered locus">Cyan10605_2162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2162"/>
    <dbReference type="EnsemblBacteria" id="AFZ54248">
        <property type="protein sequence ID" value="AFZ54248"/>
        <property type="gene ID" value="Cyan10605_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2162"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2297"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_3"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="44"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="283" mass="31459" checksum="CFBFCF889F6D8410" modified="2013-03-06" version="1">MKQLRELLFPSQNSKKNPPKTKGLPPIKKSRRGIEIKTEAEIEIMRVSGKIVATVLKEIQEIAKPGMTTADLDAYAEKRIREMGATPSFKGYHGFPASICACINDEVVHGIPNPKKVLKMGDIVKVDTGAFYNGYHGDSCISFPIGKIKRQGVKLLEVAEKAMYQGIEQVKAGNYLMDIAGAIQDYVEKNGFSVVENFVGHGVGRNLHEEPSVFNVRTRDLPNVKLRSGMTLAIEPIVNVGSNKTRTLKDRWTVVTIDKCLSAQFEHTVLVTDDGYEILTWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7G9</accession>
    <name>K9Z7G9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220395.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2597"/>
    <dbReference type="EnsemblBacteria" id="AFZ54672">
        <property type="protein sequence ID" value="AFZ54672"/>
        <property type="gene ID" value="Cyan10605_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2597"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2758"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_3"/>
    <dbReference type="OMA" id="RSGFEIC"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="12851" checksum="E72124C12CDA6169" modified="2013-03-06" version="1">MGNALIVDDSSTERKILTGYLQELGISVTTAESGEEALEKIKGNTPDLVVLDVVLPGKSGFEVCREIKSGTNTGKIPIIMCSTKGSEMDKFWGMKQGADAYIPKPVDKEEFLSAVKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7I4</accession>
    <name>K9Z7I4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">Cyan10605_3052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220828.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3052"/>
    <dbReference type="EnsemblBacteria" id="AFZ55109">
        <property type="protein sequence ID" value="AFZ55109"/>
        <property type="gene ID" value="Cyan10605_3052"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3052"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3251"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_3"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="363" mass="39572" checksum="B158D41AB8F290CF" modified="2013-03-06" version="1">MLRAGIVGLPNVGKSTLFNAVVANAKATAANFPFCTIEPNVGVVAVPDERLEVLAKLSKSQKIVPTRIEFVDIAGLVKGASKGEGLGNQFLANIREVDAIVHVVRCFDDDDIIHVSGSVDPLRDMDVINLELSLADLSQVEKRLERQRKQAKKEKEAGEEVEILEKILPILNEGKPARLVELTQEEKAIIKPLGLLTAKPVIYAANVSDEDLATGNDWVNQVKQQAETENAKVVIISAQVESELVELSPEEKTEFLESLGVSEGGLQSLIQATYDLLGLRTYLTTGETETRAWTILAGMTAPQAAGVIHSDFERGFIRAETVSYQDLVDCGSMTAAKEKGLVRSEGKEYIVQEGDVMLFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7L5</accession>
    <name>K9Z7L5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220430.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2633"/>
    <dbReference type="EnsemblBacteria" id="AFZ54707">
        <property type="protein sequence ID" value="AFZ54707"/>
        <property type="gene ID" value="Cyan10605_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2633"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2797"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_3"/>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="577" mass="63747" checksum="C5A1ABBF2F67B4B8" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M5</accession>
    <name>K9Z7M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220445.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2648"/>
    <dbReference type="EnsemblBacteria" id="AFZ54722">
        <property type="protein sequence ID" value="AFZ54722"/>
        <property type="gene ID" value="Cyan10605_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2648"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2813"/>
    <dbReference type="eggNOG" id="ENOG5032PCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137758_0_0_3"/>
    <dbReference type="OMA" id="MQRHGWT"/>
    <dbReference type="OrthoDB" id="1586867at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021679">
        <property type="entry name" value="Toxin_endonuclease_YhaV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11663">
        <property type="entry name" value="Toxin_YhaV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="151" mass="17969" checksum="5E38343B9DFC094D" modified="2013-03-06" version="1">MKLIKINGYLIYFHPLFYQQWLELVNRVKYLKQRSAPENFVTHPDVKLLKALDQGIKDKIPKDPFASYFALKKPLQKYSRLKKMGLPSRYRLFFRVFKEANTIIILWLGFPRKERDKKDCYKVFSKMVINGNFPEDIASFLDLANNSENDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Q1</accession>
    <name>K9Z7Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="81" mass="9436" checksum="BD73E40389388A97" modified="2013-03-06" version="1">MSAYPEILKEVQKMPITEQFKLFNTLKNSLSKYIETEDSEEIILAEEIAESEQAWREYITVKDKGINSQDLKKKLLIAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7R7</accession>
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        </submittedName>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="RWSIGAY"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="267"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="304"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="834" mass="93432" checksum="99698E7A88880A74" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T0</accession>
    <name>K9Z7T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220182.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2375"/>
    <dbReference type="EnsemblBacteria" id="AFZ54458">
        <property type="protein sequence ID" value="AFZ54458"/>
        <property type="gene ID" value="Cyan10605_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2375"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2522"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_2_2_3"/>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="OrthoDB" id="729805at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="233" mass="26206" checksum="EBEBD6EBBA5CFB7C" modified="2013-03-06" version="1">MITIRPSEERGKANLGWLDSKHTFSFGSYYDPNYMGFASLRVINEDKIAPTQGFNTHSHQNMEIITYVLEGELEHKDSIGNGSIIRPGDVQRMSAGRGIAHSEFNPSSQETVHLLQIWIQPNQIGVDPSYEQKYFADDEKQGKLRLIASEDGREGSVKIHQDADLYVMLLGKNEEIKHNIPENRSLWLQIVRGSGKINGHIVNVGDGVAITQEKKLDFIATEDNTEILLFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7T7</accession>
    <name>K9Z7T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220520.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2725"/>
    <dbReference type="EnsemblBacteria" id="AFZ54797">
        <property type="protein sequence ID" value="AFZ54797"/>
        <property type="gene ID" value="Cyan10605_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2725"/>
    <dbReference type="eggNOG" id="ENOG502ZBKN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120364_0_0_3"/>
    <dbReference type="OMA" id="FRLKMRP"/>
    <dbReference type="OrthoDB" id="1559337at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018971">
        <property type="entry name" value="DUF1997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09366">
        <property type="entry name" value="DUF1997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="21611" checksum="537C8C803D2B5916" modified="2013-03-06" version="1">MQICFQAEETVKLEVKQQAIPIQHYLRQPSRLVKAIADRKLMTALKDDCYRLQMHPLSFLDMYHFQPTAVLKVWSGASGNVYVNSVSCEIKGIEYLNRRFSLQLKGKLTPTEIEGKVYLQGKANLTVTVDLPPPLWLTPKSLLLTTGNSLLKGVLVRIKNKLMSQLLNDYYDFVKSEQEKTHSLGWQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7W7</accession>
    <name>K9Z7W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Cyan10605_0779</name>
        <name evidence="16" type="ordered locus">Cyan10605_2759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218643.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ52912">
        <property type="protein sequence ID" value="AFZ52912"/>
        <property type="gene ID" value="Cyan10605_0779"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54827">
        <property type="protein sequence ID" value="AFZ54827"/>
        <property type="gene ID" value="Cyan10605_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0779"/>
    <dbReference type="KEGG" id="can:Cyan10605_2759"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2929"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_0_3"/>
    <dbReference type="OMA" id="SYHCVGI"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ54827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="408" mass="46493" checksum="24C7D8EE82551F47" modified="2013-03-06" version="1">MLKVIKIRIYPDSSQKLALAKAFGSCRWLWNHFLNLMNETYKQTGKGLSGYDVKKLIPELKKQEETSWLSETYSQCLQQVCLNLGVAFNNFFEKRAKYPNFKSKHGKQSLQYPSNVSIKGDCFNVPKIGLVYAKIHRPIDGKIKTVTITKNCCNQYYASVLVDDGKDKPKVSSEGKAIGIDLGLNHFAITSDGSKFDNPKILKKHEVNLKRKQQQLSRKQKGSNNRNKARLKVAKVHKKITNCREDFLHKLSRRIVNENQVIVLEDLNVKGMIKNHCLAKAIQQVGWGQFCTMLKYKAEQEGKTYMEVDRFFPSSKTCHVCLKRVDSLPLDIRHWECPKCKTKHDRDINAAINIRDEGLRILKTGLTRSGNKFRTQPLTSGTGDKAYCPDVRRGRGGRKKSTTPLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y5</accession>
    <name>K9Z7Y5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.88</ecNumber>
            <ecNumber evidence="10">1.5.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="10"/>
    <dbReference type="EC" id="1.5.5.2" evidence="10"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220972.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3206"/>
    <dbReference type="EnsemblBacteria" id="AFZ55254">
        <property type="protein sequence ID" value="AFZ55254"/>
        <property type="gene ID" value="Cyan10605_3206"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3206"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3418"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005682_2_0_3"/>
    <dbReference type="OMA" id="PPWNFPV"/>
    <dbReference type="OrthoDB" id="14333at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041514">
        <property type="entry name" value="PutA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18083">
        <property type="entry name" value="PutA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000197">
        <property type="entry name" value="Bifunct_PutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01237">
        <property type="entry name" value="D1pyr5carbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PutA_N" evidence="9">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="137"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="556"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 4">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114879" checksum="69F6B77D9AD5C7C5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z831</accession>
    <name>K9Z831_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221069.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3306"/>
    <dbReference type="EnsemblBacteria" id="AFZ55351">
        <property type="protein sequence ID" value="AFZ55351"/>
        <property type="gene ID" value="Cyan10605_3306"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3306"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3520"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_0_3"/>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="246" mass="27679" checksum="CB4F792526DE2CBD" modified="2013-03-06" version="1">MCTDCGCSVTPDIVKINHKIEYQHQLKTLNIHQDILSKNNHIANHCRDLFKQKNIYTLNILSSPGSGKTTFIQKTLTDLKDIYKSAVIVGDLATDNDAQRLKQTSAQVVQITTGNICHLEAEMIRQALKEINLDNCQLLMIENVGNLVCPSAYDLGENKRIALLSVTEGEDKPLKYPTLFKSADVVIINKIDIAEAVEFNQKLALKNIHQIAPQAKIFMVSSRKGNGMNNWYHYLHQISTIKTTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z864</accession>
    <name>K9Z864_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220483.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2686"/>
    <dbReference type="EnsemblBacteria" id="AFZ54760">
        <property type="protein sequence ID" value="AFZ54760"/>
        <property type="gene ID" value="Cyan10605_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2686"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2851"/>
    <dbReference type="eggNOG" id="ENOG502Z7RA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058545_0_0_3"/>
    <dbReference type="OMA" id="FFRRQMN"/>
    <dbReference type="OrthoDB" id="1652108at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009472">
        <property type="entry name" value="Tab2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34556">
        <property type="entry name" value="PTHR34556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06485">
        <property type="entry name" value="Tab2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="294" mass="33247" checksum="913288903640F13F" modified="2013-03-06" version="1">MGKIWELDFYSRPIIDENNKKRWEILICESPTTIDTDTSQLFRYSQFCANTEVNSITLQNAIATAIEKAGETPSKIRFFRRQMNNMILKGCEDAGIPALASRHTYTLNQWLEERMTSFYPLQEGYDEKATIAASVQYPQTNPVNLPDALKGDKKDKWALVSLNGKDLEEMPEWDIGFREAFPLKIANISPDTKIPGLIIFSSRALPLAGWMSGLELGYLRLDRGKFPSICLETGVSDSWILVNLTDKNTLSEAEGFENTKKQANGVHFLAIQSSPESQSFEAFWLLLEQSSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B3</accession>
    <name>K9Z8B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_3347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221107.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3347"/>
    <dbReference type="EnsemblBacteria" id="AFZ55389">
        <property type="protein sequence ID" value="AFZ55389"/>
        <property type="gene ID" value="Cyan10605_3347"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3347"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3565"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_3"/>
    <dbReference type="OMA" id="TVCVWTL"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="401" mass="44406" checksum="1B1AD82E6F3196CF" modified="2013-03-06" version="1">MSKLSLNPQVWILAGGRLLLQFGTGFTLFYAPIFFVNELNFSPTMVGIALGSSSVSGIVGRFWGGSWSDSLKWGRKKTLLLSALISAVADIFLILTHNYLFLLLGNLLMGLGIGLYWPPAEAAVADLTTEKQRNSAFALSRLGDNIGLGLGVAVGGWLIALTNNYRLLFIIDGFSFILFYLVIKFTIKESYHGGKEGDEDNWQNWQKALKDKRLWVFCFINILFTTYISQIQSTLPLYLTNFTNSNQFSITNLSGLFSLHIAFAALFQLPVVKILNRLSHLRGLMFSALIWGISFALVWLTGNVNNYAFYWGILAVLLGAIALTTYNPAASAFVVDISPESLRGIYFAINSQCWAIGYLIGPPLGGWVLDQGEVYAHNFWLILALSVAIAVFALQYLISKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8F6</accession>
    <name>K9Z8F6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">Cyan10605_2798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell inner membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2798"/>
    <dbReference type="EnsemblBacteria" id="AFZ54865">
        <property type="protein sequence ID" value="AFZ54865"/>
        <property type="gene ID" value="Cyan10605_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2798"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2974"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_3"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ54865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="342" mass="37363" checksum="9B8F23773CDCC067" modified="2013-03-06" version="1">MYADKGQQPLTQSLLFIFSFMSKSISQSHLYTIASGITGGILLVLFSQSVTLSQPVENIPNNSVSSMNVFQAFILGMVQGLTEFIPISSTAHLKAIPVALGWGDPGVTFTAIIQLGSIVAVLWYFWQDLMDLGVGITKAIRNQNYQTQEFKIGVGIVIGTIPIVIFGLMLKLFVKDLDNSAFRSMTTIAIASIVMAILLALSEKFSQHQRDFEHLSTKDGILMGFAQSLALIPGVSRSGSTITAGLFMNLQRATAARFSFLLGIPAITLAGLVEFKDVFSAGYNSTSIVSLIVALISSGIFSYLAIAWLIRYLQRQDTWVFVWYRLAFGVVILVAIFSKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8I4</accession>
    <name>K9Z8I4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Cyan10605_3429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221187.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3429"/>
    <dbReference type="EnsemblBacteria" id="AFZ55469">
        <property type="protein sequence ID" value="AFZ55469"/>
        <property type="gene ID" value="Cyan10605_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3429"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_1_1_3"/>
    <dbReference type="OMA" id="SSVWIDF"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ55469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="131" mass="15463" checksum="FAA4FFC00ABE7C09" modified="2013-03-06" version="1">MYLIDTSVLVNIFRDKTGIKRKNLENIIQDNPFFLSHFIQMELLQGAKDEKEWQLLEIYLDDQDYLTENSSILIKSARIFYDLRRKGLTVRSTIDCCIAQLAISYNLILIHNDKDFETIKKVRDLQTIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J7</accession>
    <name>K9Z8J7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221239.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55521">
        <property type="protein sequence ID" value="AFZ55521"/>
        <property type="gene ID" value="Cyan10605_3486"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3486"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_3"/>
    <dbReference type="OMA" id="IMPHDFR"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="313" mass="35292" checksum="A6299CC6DF0B7FAD" modified="2013-03-06" version="1">MLSQTNNPESLQLSAPIPLTLHPAAVYLSGLRNNSYRSIRYCLDTVAKILSQGQCDCITIDWSKIRYHHTMALRSALIDKYHPTTINSMLTAFKRVLGETQKLGLMEFEVYQKTVDFKKVVGTAEPKGRALSKKEIGQIIATCDGNSPTDIRDRAIIGILRGGGLRRGELINLELRDLELDTGKLIIRQGKGHKTRHVYIPSSALEFVKQWLQLRGYEDGYLFCRIHRGGHLKMGKMHSDSIWRMLQKRAKMANLKSCCPHDLRRTFCGDLLSAGVDIVTVQKLAGHASPITTASYDRRDDEIRRNAVENLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Q7</accession>
    <name>K9Z8Q7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3543"/>
    <dbReference type="EnsemblBacteria" id="AFZ55576">
        <property type="protein sequence ID" value="AFZ55576"/>
        <property type="gene ID" value="Cyan10605_3543"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3543"/>
    <dbReference type="HOGENOM" id="CLU_2971834_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="58" mass="6994" checksum="E0FC5F8E1196D314" modified="2013-03-06" version="1">MKIELVINGKIIEILEQDKEDKQIWNIESGSWLYGNEIVDYINWRFDNPPVFLDDIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8Z3</accession>
    <name>K9Z8Z3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54843">
        <property type="protein sequence ID" value="AFZ54843"/>
        <property type="gene ID" value="Cyan10605_2775"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2775"/>
    <dbReference type="HOGENOM" id="CLU_3151897_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5445" checksum="3E4B0FD05F332A92" modified="2013-03-06" version="1">MKGLRRLESPIVSYSFCGNILIQVQSAINVVLYNEELWMSAKSDQSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z952</accession>
    <name>K9Z952_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2851"/>
    <dbReference type="EnsemblBacteria" id="AFZ54918">
        <property type="protein sequence ID" value="AFZ54918"/>
        <property type="gene ID" value="Cyan10605_2851"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2851"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3030"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749294_0_0_3"/>
    <dbReference type="OMA" id="KKSVYQP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="393" mass="44731" checksum="BCAF80B4C782AED3" modified="2013-03-06" version="1">MNKLTEKFFSVLKITTSSGEIMTTSEKKDSSINKVISLLIICASLGITYLPIFPIKTNVTIVSGSELKEVLEEISDKFEKDNPHIDLEIEIQGSQDMISNVIDKKNDFIPTILIPANSELITELENRLKAQGETNIFYNPPEVITRTLLVAIAWEERGKVLFPNNKFSWNQLEKALKVRNWQQLGGDKNWGSFDFVTTDPTRSNSGQLTLSLWAKNDLNQNILTVNDINNNQIIDLFTLIKKSVYQPPRSTDILLQEFIARGANDADVATVYESIALYRWSQAKERRNQGYQIYYPNPTIETTISGVVLKQNVNNQEAKSAKKFINYLREKEQQIIFAKYGFRPIIDLNLANLKETPWSNNISGVEIKPNTNIKPSPDSNVINEIEKIWNQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9G9</accession>
    <name>K9Z9G9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="11" type="synonym">atpB</name>
        <name evidence="13" type="ordered locus">Cyan10605_3328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cellular thylakoid membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221090.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z9G9"/>
    <dbReference type="STRING" id="755178.Cyan10605_3328"/>
    <dbReference type="EnsemblBacteria" id="AFZ55372">
        <property type="protein sequence ID" value="AFZ55372"/>
        <property type="gene ID" value="Cyan10605_3328"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3328"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3543"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_3"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="154"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="482" mass="51947" checksum="C3E1D783615F4FCF" modified="2013-03-06" version="1">MVAVQEKTNVGKITQIIGPVVDAEFPSGSLPRIYNALRVEGTNSAGEKVAVTCEVQQLLGDNQVRAVSMSTTDGLVRGMEIVDTGAPISVPVGKATLGRIFNVLGEPVDNKGDVNTSETFPIHRKAPAFTELDTKPTVFETGIKVVDLLTPYRQGGKIGLFGGAGVGKTVIMMELINNIAIQHGGVSVFGGVGERTREGNDLYNEMIESKVIDPDNPENSKIALVYGQMNEPPGARMRVGLSALTMAEYFRDVNKQDVLLFIDNIFRFVQAGAEVSALLGRMPSAVGYQPTLGTDVGDLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDGTTVLSRNLAAKGIYPAVDPLGSTSTMLQASIVGKEHYETARAVQSTLQRYKELQDIIAILGLDELSEEDRIVVDRARKIERFLSQPFFVAEVFTGSPGKYVSLEDTIKGFQKILSGELDDLPEQAFYMVGNIDEAIAKAEKMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9L3</accession>
    <name>K9Z9L3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_3013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220792.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3013"/>
    <dbReference type="REBASE" id="58391">
        <property type="entry name" value="M.Cap10605ORF3013P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55073">
        <property type="protein sequence ID" value="AFZ55073"/>
        <property type="gene ID" value="Cyan10605_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3013"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3210"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_0_1_3"/>
    <dbReference type="OMA" id="YLTEREC"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="344" mass="38650" checksum="067C6FD9B071307F" modified="2013-03-06" version="1">MKVLKYVKFIDLFAGIGGFHQALSYYGAKCVFASEWDKHCQGIYLKNYGILPEGDITIIPENEIPSHDILCAGFPCQAFSISGKQLGFNDTRGTLFFDIVRIAQYHQPSLLILENVKNFARHDEGKTLKVVENSLNEIGYDVFYKVLNASNFGVPQKRERIYILGFRKDLNVKKFIFPHSYSKATSLIDFCLDDSEIKDFIINRSDIKIKNNLEINRDIFGNYPQKPIRIGMINKGGQGERIYHQFGHAITLSAYGGGAGAKTGIYLINGKIRKLASRECARIMGFPDDFVISDSKNIAYKQFGNSVVVNVLKSIVEKIFAVDNLVTFHPKVVSLSSFAGDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9X2</accession>
    <name>K9Z9X2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3115"/>
    <dbReference type="EnsemblBacteria" id="AFZ55168">
        <property type="protein sequence ID" value="AFZ55168"/>
        <property type="gene ID" value="Cyan10605_3115"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3115"/>
    <dbReference type="eggNOG" id="ENOG5032S65">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174734_0_0_3"/>
    <dbReference type="OMA" id="IVVWQAK"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032568">
        <property type="entry name" value="DUF4926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16277">
        <property type="entry name" value="DUF4926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="96" mass="11265" checksum="02B7095823A74EB4" modified="2013-03-06" version="1">MLLQQLVQEEMFINDQIIEKMNKPELLDAIELLVDIAQYSLRKGEQGTIVEDYENEFYEVEFTNRKGEATALCTINQDKFTVVWSAKTQQWLTFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA08</accession>
    <name>K9ZA08_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221274.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3524"/>
    <dbReference type="EnsemblBacteria" id="AFZ55557">
        <property type="protein sequence ID" value="AFZ55557"/>
        <property type="gene ID" value="Cyan10605_3524"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3524"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132565_0_0_3"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="173" mass="19876" checksum="0D049A1092583B0A" modified="2013-03-06" version="1">MSLDSILDKTFKFDFDQTLIDSRQAEIYRKNREWSKVYDLIPQLLPYNGINELLYNLKSNNLKIGIVTSSPKNYCLKVINYWGWQIDSIVAYHDTVYHKPHPESLYKAIQQLSGEANSVIYVGVQEDDIIASSQAGILSVYATWGLTKVNQNINADYIFTQVSQLSQFILDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZA18</accession>
    <name>K9ZA18_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221282.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3534"/>
    <dbReference type="EnsemblBacteria" id="AFZ55567">
        <property type="protein sequence ID" value="AFZ55567"/>
        <property type="gene ID" value="Cyan10605_3534"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3534"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_5_0_3"/>
    <dbReference type="OrthoDB" id="1840421at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="278" mass="31820" checksum="39ACD42D818BC15E" modified="2013-03-06" version="1">MSKGIALHIGINKVDNEYYGVEIPPLLACENDAIEWEKISQSKGFNSQVLLSSSATADNIIKQIKNSAKQLKSGDVFFLTYSGHGSQIPDLNHDEEDSLDECWIAYDKPILDDELEILWTKFNEGVKIVLISDSCHSGTMVKSLKRRKILHPRNLSFTVRNQIWSDHKKYNKLIKKLDKLADKKGNLELKANIICLSACQDYQLAFEGENHGLFTECLLKIIHQNEKPKWGQKPKRLTANYLINTAKKMLKGKQIPMYYKSDNITRTYLLQEIFSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAA5</accession>
    <name>K9ZAA5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
            <plasmid evidence="3">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221243.1">
        <property type="nucleotide sequence ID" value="NC_019777.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3490"/>
    <dbReference type="EnsemblBacteria" id="AFZ55525">
        <property type="protein sequence ID" value="AFZ55525"/>
        <property type="gene ID" value="Cyan10605_3490"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3490"/>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280710_0_0_3"/>
    <dbReference type="OMA" id="VIPINID"/>
    <dbReference type="OrthoDB" id="85942at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="1118" mass="128054" checksum="14D7350BD38468D8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZ73</accession>
    <name>K9YZ73_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">Cyan10605_0038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217931.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0038"/>
    <dbReference type="EnsemblBacteria" id="AFZ52199">
        <property type="protein sequence ID" value="AFZ52199"/>
        <property type="gene ID" value="Cyan10605_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0038"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.40"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_3_3"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="219" mass="24551" checksum="81F346AF7CB833A4" modified="2013-03-06" version="1">MFLFGLGNKKLTLPTPEEALPGRKDKMPIPSKHYVNGNPMKPPYPETMEKAMFGMGCFWGAERKFWQLEKGIFITAVGYSAGLTPNPTYEEVCSGLTGHNEVVLVVYDPKIISYETLLKVFWENHDPTQGMRQGNDKGTQYRSGIYTFSDTQKALAEKSKALYQEELSKAGYTEITTEIIDAPEFYFAEGYHQQYLAKNPNGYCGLGGTKVCLPNTNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZJ7</accession>
    <name>K9YZJ7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADPH-protochlorophyllide oxidoreductase</fullName>
            <ecNumber evidence="6">1.3.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a</text>
            <dbReference type="Rhea" id="RHEA:11132"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83348"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="EC" id="1.3.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. POR subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218071.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0183"/>
    <dbReference type="EnsemblBacteria" id="AFZ52339">
        <property type="protein sequence ID" value="AFZ52339"/>
        <property type="gene ID" value="Cyan10605_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0183"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.190"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_3_3"/>
    <dbReference type="OMA" id="WSWGNRQ"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016630">
        <property type="term" value="F:protochlorophyllide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005979">
        <property type="entry name" value="Prochl_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44419">
        <property type="entry name" value="PTHR44419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01289">
        <property type="entry name" value="LPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0149">Chlorophyll biosynthesis</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="322" mass="35629" checksum="DDB8419A8561B712" modified="2013-03-06" version="1" precursor="true">MTTDNKPTVIVTGASSGVGLQAARALTQKGWFVIMACRNIDKTLKAANEVGIKSGDYQIIHIDLADFDSVRKFVQDFRATGRKLDALVCNAAVYYPLLKEPLRNKDGYEISVATNHLGHFLLCNLMLEDLQKSGNPEPRLVILGTVTANPKELGGKIPIPAPPDLGNLDGFKQGFKPPISMIDGKKFKSGKAYKDSKLCNMLTMRELHRRYHQSTGITFSALYPGCVATTALFRNHYSLFQKIFPLFQKNITGGYVSEELAGERVAMVVADPEYNQSGVYWSWGNRQKEGRKSFAQEISDEASDTDKGVLMWDLSKQLVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZN0</accession>
    <name>K9YZN0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_0256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218138.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0256"/>
    <dbReference type="EnsemblBacteria" id="AFZ52406">
        <property type="protein sequence ID" value="AFZ52406"/>
        <property type="gene ID" value="Cyan10605_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0256"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.265"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039913_0_0_3"/>
    <dbReference type="OMA" id="DYIRYPR"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="103"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ52406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="480" mass="55161" checksum="38CD26DD0B2BEE25" modified="2013-03-06" version="1" precursor="true">MQKLSWLNISLIFISLISQTLFQLPSYGVTNPYCQLDQNSINIKNNLREKAISGDNNAQREYQQLIQQHSQQLNNCRRNHWLKEQAIWLRLYPCDAKAGSIDRVLDQIVNLGYNTVYLEVFYDGRVLLPKNGNFTAWDSVLDAPGYENRDLYAETLEKARQRGLKIYAWLFSLNFGYVYAQRSDRTSVLARNGRGENSIDFVHDQSQAFVDPYSRQARQDYSQMLQAILQRRPDGVLFDYIRYPRGSGNESVVGKVKDLWIYSPASKETLLNRATNRQGRWLLERYITKGSINGNDIEEMKRLYPDEKTPLWQGRNPNAPNNLSNLQIETWYFTVAHAAQGVIDFLDFVSSQVQQRGIPAGAVFFPDGNQVVGEIGFDSRLQPWDSFSPRIEWHPMSYALCGSPNCIIDQVKRVTQASAQDSNVKPVLAGFWGRNDGKRPSLESQMEGIRNSVKGVQSISHFAYSWLEPEHTRERQSCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9YZS1</accession>
    <name>K9YZS1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisZ</name>
        <name evidence="8" type="ordered locus">Cyan10605_0264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218146.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0264"/>
    <dbReference type="EnsemblBacteria" id="AFZ52414">
        <property type="protein sequence ID" value="AFZ52414"/>
        <property type="gene ID" value="Cyan10605_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0264"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.274"/>
    <dbReference type="eggNOG" id="COG3705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_0_2_3"/>
    <dbReference type="OMA" id="ELVMPPM"/>
    <dbReference type="OrthoDB" id="1236894at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-synt_His" evidence="7">
        <location>
            <begin position="8"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="404" mass="45122" checksum="1A581CB313D975B3" modified="2013-03-06" version="1">MIHQAPAGARDLLPLEVAQKSWINDRLQEVFQRWGYKRIVTSTIEWVDTLMAGGAIEPSTVVQLQNIGEGRLGLRPELTASIARAAVNRLSNQTIQRLCYRANVFRNPPAGHHGKQLEFYQAGVELLYAEGVLADGEIILLLINCLQSLGIEGAQLLLGDAGLTRSLLNTFPCAFREQILDAIASLDRVKLQKLDLEDNLKSKALQLFDLRGNPQEVLARVADFDLDETAQKAVNHLQSLMDLINHSCEKPLPITLDLSLIQTFDYYTGIVFEIVQVMGNKPYVLGQGGRYDQLLEVYHPQKKNAPGIGFCFNIQDLHNCLLNSPNLPQSTPPSDWLVIPTNIKASNSAFAYAQKLRNTNHIVRVEIDLKMRTPDEIRNYALEEGISYLAWVDENGNAKIETAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z062</accession>
    <name>K9Z062_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_0449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218322.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0449"/>
    <dbReference type="EnsemblBacteria" id="AFZ52591">
        <property type="protein sequence ID" value="AFZ52591"/>
        <property type="gene ID" value="Cyan10605_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0449"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.475"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_3"/>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="575" mass="64473" checksum="E0457E1C74260ECB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0B0</accession>
    <name>K9Z0B0_CYAAP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217894.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0001"/>
    <dbReference type="EnsemblBacteria" id="AFZ52162">
        <property type="protein sequence ID" value="AFZ52162"/>
        <property type="gene ID" value="Cyan10605_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0001"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1"/>
    <dbReference type="eggNOG" id="ENOG502Z8H2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091325_0_0_3"/>
    <dbReference type="OMA" id="MVHRHIH"/>
    <dbReference type="OrthoDB" id="1700646at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021809">
        <property type="entry name" value="DUF3386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11866">
        <property type="entry name" value="DUF3386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="212" mass="24200" checksum="0D7298D1E8B4FDD6" modified="2013-03-06" version="1">MTQTLTAEQLFRNAYENRYTWDENFPGYTCDITYKTPTATYTAKGKIESNLQFSISDIEDSSAQKAIQQQLWEITIHRVNHSFEKSHGENTFSFGETDADGAVEILVGGASQGNKYKVKDNVVTLVYRKIRDIFVTINTFEVLHTDKGYLSLGYDSIYADAQTGEQKGAKSIFHDKFEKVGDYYVLTNRQIITEENEQPTITEFSFSNIVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0I8</accession>
    <name>K9Z0I8_CYAAP</name>
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        <submittedName>
            <fullName evidence="2">Glutamine synthetase inactivating factor IF7</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Cyan10605_0555</name>
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    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
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        <lineage>
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            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0555"/>
    <dbReference type="EnsemblBacteria" id="AFZ52696">
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        <property type="gene ID" value="Cyan10605_0555"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|755178.3.peg.586"/>
    <dbReference type="eggNOG" id="ENOG5032YXH">
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    </dbReference>
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    <dbReference type="OMA" id="SHYWNPI"/>
    <dbReference type="OrthoDB" id="2052750at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7530" checksum="A533E88A8F72E193" modified="2013-03-06" version="1">MSAESQARSLMMRHHKFIKNRQQSMLGRTASEIGMDINGSEYWNPVQGKPNSSFRVSYDRSHASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0J9</accession>
    <name>K9Z0J9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218410.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0538"/>
    <dbReference type="EnsemblBacteria" id="AFZ52679">
        <property type="protein sequence ID" value="AFZ52679"/>
        <property type="gene ID" value="Cyan10605_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0538"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.569"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081870_0_0_3"/>
    <dbReference type="OMA" id="LIHPIGV"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="301" mass="34496" checksum="C1105F1D0CA49DD6" modified="2013-03-06" version="1">MTITPSTQYYNWNKYKCAYTSYNTESNFPYAIILIHPIGVGLSGIFWHRFLSNSTVSESQIPIYNPDLLGCGESDLVRLAYDPKDWASQLNHFIMNVVKKPVILVVQGASFPIAIYMSAGDLKCDLIKGLILSGPPAWNIMINGGNLRVSEIIWNLFFDSFIGSLFYQYARRRDFIKSFSIKELFGEEKDVDDEWLDMLEKAATNSMSRYAVFSFLAGFWRKDYSKLMAKLDQKILLLMGEKATSVSKEGFKETPDQRIELYQKNIPNLTGKKLKGRNVLPYESTEDFVKETINFCQSFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0Q1</accession>
    <name>K9Z0Q1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218497.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0627"/>
    <dbReference type="EnsemblBacteria" id="AFZ52766">
        <property type="protein sequence ID" value="AFZ52766"/>
        <property type="gene ID" value="Cyan10605_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0627"/>
    <dbReference type="eggNOG" id="ENOG50337J6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189064_0_0_3"/>
    <dbReference type="OMA" id="QWINTRN"/>
    <dbReference type="OrthoDB" id="2047829at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="72" mass="8562" checksum="E4E81D3AD328E0FB" modified="2013-03-06" version="1">MIDPHYPHIVIAFDYRNCRVEVEKDSFQGEEIYSVWVNYGFQCVVLTPCCYSKTEAIRKGKHWIDSQLIFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1D7</accession>
    <name>K9Z1D7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="6" type="synonym">rps4</name>
        <name evidence="11" type="ordered locus">Cyan10605_0231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218117.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0231"/>
    <dbReference type="EnsemblBacteria" id="AFZ52385">
        <property type="protein sequence ID" value="AFZ52385"/>
        <property type="gene ID" value="Cyan10605_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0231"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.240"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_5_3"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ52385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="202" mass="23117" checksum="29BDB220CE324CBB" modified="2013-03-06" version="1">MARYTGPRLRVVRRLGDLPGLTRKNARRSYPPGQHGQNRRKRSEYAIRLEEKQKLRYNYGVSEKQLVRYVKKARRVTGSTGLVLLQLLEMRLDNTVFRLGMAPTIPSARQLVNHGHIMVNGQVVDIASYQCRPGDIISVRNRDKSTNIVKTNLLNPGLANLPSHLEFDKDNLTGKVNGVIEREWVALNINELLVIEYYSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1G5</accession>
    <name>K9Z1G5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="7">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DTB synthetase</fullName>
            <shortName evidence="7">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bioD</name>
        <name evidence="8" type="ordered locus">Cyan10605_0017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity). This cyanobacterium does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction. Thus in this organism BioD has a different substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:63684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149470"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217910.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0017"/>
    <dbReference type="EnsemblBacteria" id="AFZ52178">
        <property type="protein sequence ID" value="AFZ52178"/>
        <property type="gene ID" value="Cyan10605_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0017"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.18"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_3_1_3"/>
    <dbReference type="OMA" id="KMLLISH"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ52178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="221" mass="24295" checksum="43BB4FBF2A30FA1D" modified="2013-03-06" version="1">MQTLLIAGTDTDAGKTIITTAFRAYLQKKKSHLVTALMKLLQTGEIGDEEFYCQYFDDAVIPLRYQAPLAPPLSAKLEGKSIDLNIVRNRLLDLQKSHDFVLVEALGGLGSPITEELIIADIAHDWVLDTILIVPVKLGAIAHTVANVALAKQYNIKLTGIIFNCVQDYTPTQINQWTPKGLIESLTGISVLGYFPYLGDVNSLNLDELANISEPIFSQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1M6</accession>
    <name>K9Z1M6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015217985.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0094"/>
    <dbReference type="EnsemblBacteria" id="AFZ52253">
        <property type="protein sequence ID" value="AFZ52253"/>
        <property type="gene ID" value="Cyan10605_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0094"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.96"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031010_0_0_3"/>
    <dbReference type="OMA" id="IAGLMNF"/>
    <dbReference type="OrthoDB" id="1083610at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007570">
        <property type="entry name" value="Uncharacterised_Ycf23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36895">
        <property type="entry name" value="PTHR36895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04481">
        <property type="entry name" value="DUF561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="25513" checksum="39F4618541E72BC7" modified="2013-03-06" version="1">MINNSKLAQAFASKKALKVISGLNNFDVENVTAVCKSAELGGATFVDIAADMDLIKTVRQLISLPICVSAVSAEILAQAVDNGADLVEIGNFDSFYAQGITFSAEDVLNLTRETRKLLPETTLSVTVPHILALDEQVELAQALVASGADIIQTEGGTSSNPNHSGILGLIEKASPTLAAAYALSRAVEVPVMCASGLSDVTAPMAIASGASGIGVGSAINKLNDQVAMIAVVRSLVEALNTASVKVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1R6</accession>
    <name>K9Z1R6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218035.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0146"/>
    <dbReference type="EnsemblBacteria" id="AFZ52303">
        <property type="protein sequence ID" value="AFZ52303"/>
        <property type="gene ID" value="Cyan10605_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0146"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815634_0_0_3"/>
    <dbReference type="OrthoDB" id="1375508at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="65"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="341" mass="37614" checksum="14063AA35C67C160" modified="2013-03-06" version="1" precursor="true">MVKWFRRDFLSILTLASAGTFFTPMISKAINSDDLEAKIFPLFTNLPGKSTMKIKAVSQGNSMDVSLNSDIPLFCGSSFKVFVLTVFLRQMEEGKVNFEEELVINDEMRVLSSPVFGGVSGKTTALIALEAMMMHSDNTATDLIMAYVTPQAVREFIAEIGLANTLIPDSISVMFSYLLGAKNGEDWGWEKINQEMNSPNLPARSIINQEQSSITEGAATPSASSTDFVNFYSRALQGEFFKQEETLTEFKRILRLPAILDKFIPSGAIGYVKGGSIDLQPQYALCLAGGVNFSADTWAYYSFMINWEDSTGKETANISSNFLNSVKASLKIIENAIYNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1S0</accession>
    <name>K9Z1S0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218835.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0974"/>
    <dbReference type="EnsemblBacteria" id="AFZ53104">
        <property type="protein sequence ID" value="AFZ53104"/>
        <property type="gene ID" value="Cyan10605_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0974"/>
    <dbReference type="eggNOG" id="ENOG5033YMW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764982_0_0_3"/>
    <dbReference type="OMA" id="QENFIDV"/>
    <dbReference type="OrthoDB" id="1751088at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021399">
        <property type="entry name" value="DUF3038"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11237">
        <property type="entry name" value="DUF3038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="147" mass="17004" checksum="6D820E0A8DF8D51B" modified="2013-03-06" version="1">MLEEQDNVQENFIDVEKVNLTPNKIKLIYLGILALGIKLESMVIPISKSELDLVVEYLSKVLQKNEELIRRACSLLEQIENSEQNNYYGIVKEYLDNFFGLSESEETLSLNLTQEQKLSLALKVLTDLLFYSSRSGQRYLHKQLQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z1V5</accession>
    <name>K9Z1V5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218875.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1018"/>
    <dbReference type="EnsemblBacteria" id="AFZ53144">
        <property type="protein sequence ID" value="AFZ53144"/>
        <property type="gene ID" value="Cyan10605_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1018"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1079"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_4_3"/>
    <dbReference type="OMA" id="YYYFFQR"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="375" mass="43263" checksum="0B2DDE251AE2A685" modified="2013-03-06" version="1" precursor="true">MKYRRFGKTELNISVFSLGLMRCCYSQSQLLSTVAKAFELGINHLELARGYGNSEAYLGRALKELNIPREKVIITTKLTPHEDKNTFSQWLDESLLNLQTDYIDCLAIHGINTPSHLDFIQKTDFLEILNKAKNEGKIKHFGFSSHGSLELIKEAILTDLFEFINIHYYYFFQRNYSVLELAKKLDLGVFIISPADKGGLLYQPSPKLEKLCKPFSPLLLTYRFLLCDRRISTLSLGASNPEELIYPLTVADRDEPLNKKEIDTFNHIENTLKQTLKTDHCSQCYQCLPCPENINIPEILRLRNLGVGLEMTEYAKYRYQMFENAGHWFWGRKGDKCTECGECLPKCPEKLNIPALLADSHDRFKGSARRRLWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z207</accession>
    <name>K9Z207_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218356.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0483"/>
    <dbReference type="EnsemblBacteria" id="AFZ52625">
        <property type="protein sequence ID" value="AFZ52625"/>
        <property type="gene ID" value="Cyan10605_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0483"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.511"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686673_0_0_3"/>
    <dbReference type="OMA" id="NTMAGWL"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="383" mass="43152" checksum="BD0E88AFE2675B0D" modified="2013-03-06" version="1" precursor="true">MNHSVSRTKSPLNLIRWLEYHWATPAYGGWVLIGIALSFFGAATNTMAGWLYVLSGMLLSLLGLNFVVAINTLKKLQIKHLAIASVSAGDELTVSLKINNPTQKNKTLISIVEHIPPTLGKEIKHNIETLPPGQEILLTAYLQTNNRGIYHWDYLSLRTAAPFGLFYCSRYYQVKTSAIVYPHILTLQNCPLIDNLGQEEARKRDSNQVYNHATEGVTKALRQYRYGDPIRLIHWRTSARLGELQVRELETITGGEEITICLDNSGDWDRQDFENAVIAVASMYCYASRQQLEVKVWIGDMGLIHGRKVTLETLAGVNYGGIMKNNIPQLPLIWISNNSNYLNSLPLGSRYFLFNKDIVSSSLKGIIYDSENSLVSQLQKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z218</accession>
    <name>K9Z218_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper resistance B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218910.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1053"/>
    <dbReference type="EnsemblBacteria" id="AFZ53179">
        <property type="protein sequence ID" value="AFZ53179"/>
        <property type="gene ID" value="Cyan10605_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1053"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1114"/>
    <dbReference type="eggNOG" id="COG3667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042913_1_0_3"/>
    <dbReference type="OMA" id="MDHTQMD"/>
    <dbReference type="OrthoDB" id="624737at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:cellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007939">
        <property type="entry name" value="Cu-R_B_prcur"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05275">
        <property type="entry name" value="CopB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="309" mass="35973" checksum="76E06A4DF53A254D" modified="2013-03-06" version="1" precursor="true">MLYKSKFIVRSSLISCLILTNFVHQIKAQEIKETIIKKPLIVNNFIDENNYQEKQEFFKQFKDDQYLNQEKNFTFAQHNHNNNNNQENDFGDPIDDNQIFYKILFDQLEYQVNDSQNIFNWDIQGWIGGDYQKLWVKTEGDVSFDDGNGEAELQLLYSKMISPYFDFQTGLRYDQLYGEKGNSRGFAVIGIEGLAPYFVEIDTALFISHQGDISARFKAEKELLLSQRLVLQPKIETNLAIQKVEEFGIGSGFNNLELGLRLRYEINREFAPYIGVSWNKLFDDTAKFAEEEGESSDDIKFVTGVRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z247</accession>
    <name>K9Z247_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_0320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218200.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0320"/>
    <dbReference type="EnsemblBacteria" id="AFZ52468">
        <property type="protein sequence ID" value="AFZ52468"/>
        <property type="gene ID" value="Cyan10605_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0320"/>
    <dbReference type="eggNOG" id="ENOG502ZCIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828243_0_0_3"/>
    <dbReference type="OMA" id="YFRTIRR"/>
    <dbReference type="OrthoDB" id="1110541at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="323" mass="38488" checksum="9D19870A6CE111AD" modified="2013-03-06" version="1">MKSQSELQTKPWWNRPLFGGVSLIERALGALNRQEIPELALSLHDTELEELEKIFPTMKMLDHEQYTDEFLLYIRIRNKVENNLEEYKGLQTFIKIFIFTTKHINYFRTIRRIELDFQGKTQIELYNFIEEQLNLTSDPNLFNQIVIEEIDKLINIIRNEPTKEALLSYKNAIDAISKDEIGLNLLILFKKYNLIDYSIFNVINAILKKLKKQNLETLKALVLVVKVNYDELEKIGRLVGIPNNEDKVIIYAKILQYIALSYRYENLLYRFNQLLEVVKNWNKQYQTLAEIRQEYPSHKYKIPESFLKAIPGEYIYNKYQEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z253</accession>
    <name>K9Z253_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218533.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0664"/>
    <dbReference type="EnsemblBacteria" id="AFZ52802">
        <property type="protein sequence ID" value="AFZ52802"/>
        <property type="gene ID" value="Cyan10605_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0664"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.700"/>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_3"/>
    <dbReference type="OMA" id="QPIQIVC"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28216" checksum="7E3BF90F9ED5FD94" modified="2013-03-06" version="1">MTNRSKPHITAIIATSLNGKISTDVNTRAKFTSVNDFHHLETQVSLCDAVIFGANTLRAYGTSLSIKDPKLIKERQARHQQPQPLHIVCSPSGNLKPDWAFFSQPIPRGLITTKEGLNTWHENINTFPNCNNDIQYSSKEGEKSYFQNIFISESSIINWHFILDNLQNMNINKIAILGGEKLITSFLKDKLIDDLWITICPLLILNSKAPNFCSTFLDENMHSIISLQLLEVINIKEEIFIHYTVDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z255</accession>
    <name>K9Z255_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">Cyan10605_1154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219005.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1154"/>
    <dbReference type="EnsemblBacteria" id="AFZ53276">
        <property type="protein sequence ID" value="AFZ53276"/>
        <property type="gene ID" value="Cyan10605_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1154"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1221"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_0_3"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="202"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ53276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="314" mass="34914" checksum="C1CF0CED3B6A65A1" modified="2013-03-06" version="1">MEVTFLGTSSGVPTKSRNVSSVALRLTQRGEIWLFDCGEGTQHQLLRSDLRTSQLKKIFITHMHGDHVFGLMGLLASCGLGADAKDIELFGPPGIEPYLKSCMKYSYTYFPYGVTIKTVEPGLVYEDEEFTVTCELLKHRVTAYGYRVSEKNKAGIFDVEKAKKAGIPSGPLYGKLKAGETITLEDGKTFSGVDFCGPTEIGRKFVYCTDTVFCENAIALAEDADVLIHEATFAHQDASMAFEKMHSTTTMAAQVALAAQVKKLIMTHFSPRYAPGNPIQMKDLLSEARAIFPETILAYDFFRYDIPRRRDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z279</accession>
    <name>K9Z279_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218973.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1122"/>
    <dbReference type="EnsemblBacteria" id="AFZ53244">
        <property type="protein sequence ID" value="AFZ53244"/>
        <property type="gene ID" value="Cyan10605_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1122"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1186"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019646_0_0_3"/>
    <dbReference type="OMA" id="YWATTKY"/>
    <dbReference type="OrthoDB" id="878207at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="619" mass="70162" checksum="7923AE627E6EAB77" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2B3</accession>
    <name>K9Z2B3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218603.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0739"/>
    <dbReference type="EnsemblBacteria" id="AFZ52872">
        <property type="protein sequence ID" value="AFZ52872"/>
        <property type="gene ID" value="Cyan10605_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0739"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.776"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143452_1_1_3"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="143" mass="16648" checksum="B053065BA46D1A05" modified="2013-03-06" version="1">MNEYYPFILIDTGIIVAFYNKGDCHHQQVINFFASCSSQLITTVGCITEAMWLLAPDVKVQTEFLSALEKGVFIAEHLLSEDYQKIKQLNQIYQDLPADFTDLSLIAISERLNIPAIATLDKDFDIYRRYRNQFFVRVFYPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2C5</accession>
    <name>K9Z2C5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1237</name>
        <name evidence="3" type="ordered locus">Cyan10605_1875</name>
        <name evidence="4" type="ordered locus">Cyan10605_3505</name>
        <name evidence="5" type="ordered locus">Cyan10605_3529</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 6">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of chromosome of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Finished genome of plasmid of Cyanobacterium sp. PCC 10605.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Gugger M."/>
                <person name="Coursin T."/>
                <person name="Rippka R."/>
                <person name="Tandeau De Marsac N."/>
                <person name="Huntemann M."/>
                <person name="Wei C.-L."/>
                <person name="Han J."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Teshima H."/>
                <person name="Chen A."/>
                <person name="Krypides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Szeto E."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Pati A."/>
                <person name="Goodwin L."/>
                <person name="Peters L."/>
                <person name="Pitluck S."/>
                <person name="Woyke T."/>
                <person name="Kerfeld C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
            <plasmid evidence="4">pCYAN10605.01</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
            <plasmid evidence="6">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1237"/>
    <dbReference type="EnsemblBacteria" id="AFZ53356">
        <property type="protein sequence ID" value="AFZ53356"/>
        <property type="gene ID" value="Cyan10605_1237"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53975">
        <property type="protein sequence ID" value="AFZ53975"/>
        <property type="gene ID" value="Cyan10605_1875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55538">
        <property type="protein sequence ID" value="AFZ55538"/>
        <property type="gene ID" value="Cyan10605_3505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ55562">
        <property type="protein sequence ID" value="AFZ55562"/>
        <property type="gene ID" value="Cyan10605_3529"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1237"/>
    <dbReference type="KEGG" id="can:Cyan10605_1875"/>
    <dbReference type="KEGG" id="can:Cyan10605_3505"/>
    <dbReference type="KEGG" id="can:Cyan10605_3529"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1305"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138407_0_0_3"/>
    <dbReference type="OMA" id="ARWHAIW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="1">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ55538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="189" mass="22332" checksum="DEF49ABCA79D4099" modified="2013-03-06" version="1">MPSRIKIEPHLSLQELEQGYRKAKQGIEKIHYQVIWLLAQGKRTSYVSHVTGYSLSWIYELVRSYNRSGAKMLGDQRQHNRGRKPLLDDQQLALLYQRLQSPPDDQGLWNGVKVAKWLTQLLDRTISPQRGWEYLKGLEYRLRCPRPNHQNSSCLEQNEWKNQLAEKKKRFNKNIPTRTFKCGLRMSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2E9</accession>
    <name>K9Z2E9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Ubiquinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218466.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0596"/>
    <dbReference type="EnsemblBacteria" id="AFZ52735">
        <property type="protein sequence ID" value="AFZ52735"/>
        <property type="gene ID" value="Cyan10605_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0596"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.629"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_3"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="454" mass="50146" checksum="8D4153BDD918624F" modified="2013-03-06" version="1">MSNLEKRSSLPHVVIVGGGFAGLYAAKELGNAPVKVTLIDKRNFHLFQPLLYQVATGSLSPAEICSPLRLIVGRNKNTHVVLDEVVDINPEQKQVIMREGVVNYDYLVIGTGVSHHYFGNDHWEQDAPGLKSIENALDIRRRIFLAFEEAEKLSSPQEKQEWLTFAIVGGGPTGVELAGAIAEIAHKSIKKDFKEIDTTKARIVLIEGMNRVLPPYPEDLSAKAQASLEELGVEVLTNRMVTNIDKNTLNIRHGEQEETIKARTILWAAGVKASGLSEIIADRTSAETDRAGRIMVEPDLSIKNHPNIFVVGDLAHFAHQDNKPLPGIAPVAMEEGRYVAGLIVAKEKGRQIESFSYVDKGSLAVIGNNHAVANLGFVKLSGISAWLVWVFAHIYYLIEFDNKLLVMLQWGWNYFTRGRGARLITGEISEKNLVSQSFNHGNSVSNSEKELIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2G8</accession>
    <name>K9Z2G8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photosystem I reaction center subunit PsaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Photosystem I subunit X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psaK</name>
        <name evidence="10" type="ordered locus">Cyan10605_0794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cellular thylakoid membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PsaG/PsaK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218658.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0794"/>
    <dbReference type="EnsemblBacteria" id="AFZ52927">
        <property type="protein sequence ID" value="AFZ52927"/>
        <property type="gene ID" value="Cyan10605_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0794"/>
    <dbReference type="eggNOG" id="ENOG503323W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160496_1_0_3"/>
    <dbReference type="OMA" id="FAIQKTG"/>
    <dbReference type="OrthoDB" id="2053688at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.860.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00474">
        <property type="entry name" value="PSI_PsaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035982">
        <property type="entry name" value="PSI_centre_PsaK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000549">
        <property type="entry name" value="PSI_PsaG/PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017492">
        <property type="entry name" value="PSI_PsaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037101">
        <property type="entry name" value="PSI_PsaK_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01241">
        <property type="entry name" value="PSI_PSAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81563">
        <property type="entry name" value="SSF81563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03049">
        <property type="entry name" value="PS_I_psaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ52927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="90" mass="9533" checksum="F9DE1BC2B0B8A698" modified="2013-03-06" version="1">MTLIELSFLANIPQTVEWNYNVAIVMIAANLVVVFIGRFAIQNAGVGPDLPVGKPALWKNFGLPELLATLSFGHILGAGFILGLSNAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2H2</accession>
    <name>K9Z2H2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyclic oligoadenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Cyan10605_1230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Cas10/Csm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219078.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1230"/>
    <dbReference type="EnsemblBacteria" id="AFZ53349">
        <property type="protein sequence ID" value="AFZ53349"/>
        <property type="gene ID" value="Cyan10605_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1230"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1298"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017487_0_0_3"/>
    <dbReference type="OMA" id="WVSESCY"/>
    <dbReference type="OrthoDB" id="423797at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013408">
        <property type="entry name" value="Cas10/Csm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041062">
        <property type="entry name" value="Csm1_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18211">
        <property type="entry name" value="Csm1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02578">
        <property type="entry name" value="cas_TM1811_Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="10">
        <location>
            <begin position="465"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ53349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="749" mass="85657" checksum="A11CDC04D0D92653" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2I0</accession>
    <name>K9Z2I0_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ordered locus">Cyan10605_0631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218501.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="SMR" id="K9Z2I0"/>
    <dbReference type="STRING" id="755178.Cyan10605_0631"/>
    <dbReference type="EnsemblBacteria" id="AFZ52770">
        <property type="protein sequence ID" value="AFZ52770"/>
        <property type="gene ID" value="Cyan10605_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0631"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.665"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_3"/>
    <dbReference type="OMA" id="GNCYLYW"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ52770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="419" mass="46819" checksum="CD1F279F93BA2324" modified="2013-03-06" version="1">MNDSELQPIDIVTQQAHQAFIEMGSIKGVERSKAVKQMAIKLKECLDDILQANTLDLEISKEMAVPELISDWLKLTPQRLESAIEILETLAELPDPFQKVINSPYQVTYCQNYSQLMPLGVIALIYEALPELAIITAGLAIKTGNSLILRGSSEASNTNSIIAQALQIALEDVDFPSFCLQFLPSEQGFKIEDLVTQDQYINLIIPYGRPSLIQEVTQFATAPVLKSAMGNCYLYWSLCNDLELVKHIITDSYNTIPDPVNAIEKVLINCQQKSNSITRLFNHLQEQKFTLLGDEILVNEYPEHLQLISTPMWGKPFLNHTIAFRVVDDLSSAIAWINNYSSGHANCLITDSYQEGRIFAMETDSALVYVNSSPRFYRYLPGSNSVFLGISNQKGNRRGLISLETFTTVKQIVVGSGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R2</accession>
    <name>K9Z2R2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="3" type="synonym">rps17</name>
        <name evidence="6" type="ordered locus">Cyan10605_0516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218389.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0516"/>
    <dbReference type="EnsemblBacteria" id="AFZ52658">
        <property type="protein sequence ID" value="AFZ52658"/>
        <property type="gene ID" value="Cyan10605_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0516"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.546"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_3"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="82" mass="9542" checksum="1EDF78D4CF593DA5" modified="2013-03-06" version="1">MAVKERVGVVVSNKMDKTAVVAVENRSPHPKYRKIVVKTKKYKAHDEQNQCLEGDRVRIRETRPLSKTKRWEIAEIISRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2R9</accession>
    <name>K9Z2R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219230.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1388"/>
    <dbReference type="EnsemblBacteria" id="AFZ53501">
        <property type="protein sequence ID" value="AFZ53501"/>
        <property type="gene ID" value="Cyan10605_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1388"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1466"/>
    <dbReference type="eggNOG" id="ENOG5033UEE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518483_0_0_3"/>
    <dbReference type="OrthoDB" id="2224512at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="525" mass="58829" checksum="B82BDAE935BE794E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T0</accession>
    <name>K9Z2T0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218763.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53032">
        <property type="protein sequence ID" value="AFZ53032"/>
        <property type="gene ID" value="Cyan10605_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0902"/>
    <dbReference type="eggNOG" id="ENOG50348YI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161237_0_0_3"/>
    <dbReference type="OMA" id="MELIICF"/>
    <dbReference type="OrthoDB" id="2067020at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="127" mass="14097" checksum="926E1D1E85A6FA36" modified="2013-03-06" version="1" precursor="true">MELIICFLAVVSAFTALIISVVGLVNAPTPILLAILVAGMMLTQKSIDKFTEPTVNLTEEKEKNRIEKVELNSSNSNNEKEKTIQSMVYRGSNYSRNSALDKLFSFKNKGVTQYRGAKTNHDGKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T7</accession>
    <name>K9Z2T7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219198.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1355"/>
    <dbReference type="EnsemblBacteria" id="AFZ53469">
        <property type="protein sequence ID" value="AFZ53469"/>
        <property type="gene ID" value="Cyan10605_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1355"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686400_0_0_3"/>
    <dbReference type="OMA" id="PYKGVED"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="43412" checksum="6F60CE6AF6192B75" modified="2013-03-06" version="1">MSEKKISVLIPDLSLHGTTRGYTISQGLQKLGYQVNIYGFLFGGEIYPSPPYGLSITYFHGKPLPSLVKTMFDLSGEIDGDILYVIKPQLSSFGVGLIKAWRGKKPLILDLDDWEMGEWGGDDWQYQGQIFHDVFSQDSDLRKPGHPLYLKWLEKAMNRVGGITVSSKFLEYRYGGTYLPNVRDTQVFNPDNFNGEELREKYGLNNYKLLMVTSTCKAGQGIEDILTALDQLNNPQLRLILVGGNPENKDYYQQLQEKWGKWIITIQPQSFDQIQNAIALSHIMMITPHNLPANIAKCPLELIEAMAMAKPIIATKVGEIPHILSDTGYLINPQSPAEIAQQISLLFSDYEEAKQRGKLARQRCENYYSINNLTHTLAQVLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z2T8</accession>
    <name>K9Z2T8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
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            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
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        </source>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFZ52895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="14059" checksum="3C4A35BB95C4DF40" modified="2013-03-06" version="1">MGESNPTPLEGKELLQKVKELSDIPRRQRAKECGYYTIGKNGKERVNLTAFYDAVLAAKGVPLDPERTKDGRGREATFRVSVHKNGQIVIGSSYTEKMGLKPGDEFEIKLGYKHIHLRQLDEDEA</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
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                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
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                <person name="Sivonen K."/>
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                <person name="Goodwin L."/>
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                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="21"/>
            <end position="42"/>
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            <end position="381"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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    </evidence>
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    <sequence length="415" mass="48021" checksum="844A012DD7BC7867" modified="2013-03-06" version="1">MILLSFIGTGDYKLTSYTWQNQQYETEYVIEAIAHFFNAQEIKVFTTKEAIKIHGNHLRDKIDNKFDLSYIDIPSGTDEDDIWKLFDKVVESVPENSEIIFDITHAFRSIPVIVLLASAFLEKARNVKIKGVYYGQYDPKNNRASIFDLTPAIKLLDWLTATDTFINTGSSQKLGQLLADIQIDFFRSGKAKTEEIKPNKLRNLGSTISTISENIEFIRPVELLTSAHHLTKYSGEEIREEVGIFAKPFELIIDKIEQDYAQFALENQDKADPKLIIKKHYLLIKWYVEKGLGTQAILLAREWLVTTLAILENDNYLDKEARKNIENQLNAMSGNNPERIKFYEQEITKHIEDVKQLDDTWSQLGRNRNNIAHCQMNSEQFSSKVLQRYTQELPQILANLFPQLNLTSVWFKNTR</sequence>
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<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z332</accession>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
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                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
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            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218494.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0624"/>
    <dbReference type="EnsemblBacteria" id="AFZ52763">
        <property type="protein sequence ID" value="AFZ52763"/>
        <property type="gene ID" value="Cyan10605_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0624"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.658"/>
    <dbReference type="eggNOG" id="COG2928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_1_0_3"/>
    <dbReference type="OMA" id="PTTGWYT"/>
    <dbReference type="OrthoDB" id="1305123at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ52763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="230" mass="25541" checksum="343876CACC1982A5" modified="2013-03-06" version="1">MLQRIKQDLKNDLIAGLLVVIPLATTIWLSYVIANWAIKFLTQIPKQINPFDGLHPILTNFLNFFVGLTVPFALILLIGLMARNIVGQWLLDVGERILQAIPLAGSIYKTLKQILETLFQDSQTKFRRVVMVEYPRKGVWSVGFVTGKVSGMIQEHFDKNMLSVFIPTTPNPTSGWYAVIPEEEVINLSISIEDAFKVLISGGIVSPNTNGTTSSNNSSKSLPLKDVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3I3</accession>
    <name>K9Z3I3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219483.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1650"/>
    <dbReference type="EnsemblBacteria" id="AFZ53756">
        <property type="protein sequence ID" value="AFZ53756"/>
        <property type="gene ID" value="Cyan10605_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1650"/>
    <dbReference type="eggNOG" id="ENOG5032SP8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1916042_0_0_3"/>
    <dbReference type="OMA" id="QTNGINC"/>
    <dbReference type="OrthoDB" id="1865036at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="132" mass="15279" checksum="CFDD7662B3B863DE" modified="2013-03-06" version="1">MINLEVIKHYQTNGINCDVTTKDVINKLQDWDRRFGVTISDVEHDQVTVYFQTLPDNLQELAIEIYDFCPDVIDQGYGCMDDMLSMMSESSQEINEEIRALLEGVDMDNPDFGLQILANVLKIEQKVSLWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3K4</accession>
    <name>K9Z3K4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219508.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1676"/>
    <dbReference type="EnsemblBacteria" id="AFZ53781">
        <property type="protein sequence ID" value="AFZ53781"/>
        <property type="gene ID" value="Cyan10605_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1676"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1779"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012555_0_0_3"/>
    <dbReference type="OMA" id="NLGYIIN"/>
    <dbReference type="OrthoDB" id="215562at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024019">
        <property type="entry name" value="CHP04096"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04096">
        <property type="entry name" value="dnd_rel_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="609" mass="71371" checksum="B7FAAB0A1BE9CA4A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3N6</accession>
    <name>K9Z3N6_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219466.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1632"/>
    <dbReference type="EnsemblBacteria" id="AFZ53739">
        <property type="protein sequence ID" value="AFZ53739"/>
        <property type="gene ID" value="Cyan10605_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1632"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1732"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_1_2_3"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="195" mass="21727" checksum="581CFEC60F53548E" modified="2013-03-06" version="1">MTPKFVLASASPARLKLLRMIGIEPIVHKSDYDESLINLPQPIDLVNTLAMKKAEVVAQNYHDSLILGCDSLLLVDGEIYGKPEDEEVAIARWQYMRGKMGRLYTGHGLIDTINNRQIVQCGVTDVYFADVTDEQIRAYVATGEPLKCAGCFALEGKGGVFIEKIEGCHSNVIGLSLPLLRKMLTELSYEISYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3R9</accession>
    <name>K9Z3R9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219121.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53392">
        <property type="protein sequence ID" value="AFZ53392"/>
        <property type="gene ID" value="Cyan10605_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1277"/>
    <dbReference type="HOGENOM" id="CLU_203089_0_0_3"/>
    <dbReference type="OMA" id="INIEEIW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="70" mass="8487" checksum="18557AFB28BE7BED" modified="2013-03-06" version="1">MFQLPNIYQQHLKNQFNLPQYLALYLLLNLLQNLKTIRLEEIARRFPYPIKLRSRVKKLQRFLSLIGFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3U6</accession>
    <name>K9Z3U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219531.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53804">
        <property type="protein sequence ID" value="AFZ53804"/>
        <property type="gene ID" value="Cyan10605_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1701"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1807"/>
    <dbReference type="eggNOG" id="COG1808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056545_1_0_3"/>
    <dbReference type="OMA" id="WIMPLRA"/>
    <dbReference type="OrthoDB" id="1371086at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="384" mass="42869" checksum="1967942EBB6D6DC1" modified="2013-03-06" version="1">MNKINFVRFQQIYSQWCNKKKIKAIFRWLRMLTYRLMPPSHPEEIKTLHLQLSQDSAWSKDFILCTVSSCLIATFGLIANSSAVIIGAMIVAPLMLPLRGLAFSACEGELLLFRRAFLSIVGATLVSLFLSSFIAQLVGLQEVSSEISARTQPNLIDLGIAISAGAISGFGKVRKGISDTLAGTAIAVALMPPLCVVGISLTMDNYSYALGAFLLYATNLLGITLACMIVFIISGYTKPSQALGWTSLLTLLLIIPLSASFYRLIQQQRIEREIRAKLVNETITVGTGVEDTQIQVIWTTQTPTIYVTMETDKEITPNQVRLVQDFLNQRLQREFELVFYVVPLHRITTEIPTDNPQPSDITKPTKDNIRWQIDKNNYLKPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z3V4</accession>
    <name>K9Z3V4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase with Chase2 sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219608.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1779"/>
    <dbReference type="EnsemblBacteria" id="AFZ53881">
        <property type="protein sequence ID" value="AFZ53881"/>
        <property type="gene ID" value="Cyan10605_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1779"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1888"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013805_0_0_3"/>
    <dbReference type="OMA" id="HFSDRYQ"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="455"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="722" mass="81364" checksum="8E5137FAF96280FC" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z491</accession>
    <name>K9Z491_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAB/ELIP/HLIP-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1451"/>
    <dbReference type="EnsemblBacteria" id="AFZ53562">
        <property type="protein sequence ID" value="AFZ53562"/>
        <property type="gene ID" value="Cyan10605_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1451"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1539"/>
    <dbReference type="eggNOG" id="ENOG5032Z0N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171075_4_0_3"/>
    <dbReference type="OMA" id="LPRFGFH"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="56" mass="6219" checksum="52B82CC4CB2008C9" modified="2013-03-06" version="1">MNQPEPTKTPNVEDPKFGFNDYAEKLNGRAAMIGFIITLAIEYFSGQGLLSWLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z496</accession>
    <name>K9Z496_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219741.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1920"/>
    <dbReference type="EnsemblBacteria" id="AFZ54016">
        <property type="protein sequence ID" value="AFZ54016"/>
        <property type="gene ID" value="Cyan10605_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1920"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2040"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537538_0_0_3"/>
    <dbReference type="OrthoDB" id="406282at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="174" mass="19139" checksum="86B296DB7F86EFEF" modified="2013-03-06" version="1">MINKKVKSLKIAIAPYFGGYIGNSNNKDTLISWTKEADGGLSKLFDEINNGGLLSNSPSGGALAKSYQDMSSYLQLAKEQGLSLVAYEGGQHLVDKTATPEIIDLFAKANRDPRMGEIYKEYFQTWFNMGGGEFINFNDVGSYGKYGYWGLTEGLNQSSPKYEAVMDLINNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4B9</accession>
    <name>K9Z4B9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein CapD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_1085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1085"/>
    <dbReference type="EnsemblBacteria" id="AFZ53208">
        <property type="protein sequence ID" value="AFZ53208"/>
        <property type="gene ID" value="Cyan10605_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1085"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1149"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_0_3"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="318"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ53208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="655" mass="73544" checksum="E85CF951C320DD70" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4F4</accession>
    <name>K9Z4F4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_1131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218982.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1131"/>
    <dbReference type="EnsemblBacteria" id="AFZ53253">
        <property type="protein sequence ID" value="AFZ53253"/>
        <property type="gene ID" value="Cyan10605_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1131"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1198"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_3"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="148"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="307" mass="34117" checksum="4F07C27A8794ABFC" modified="2013-03-06" version="1">MVNLKGRDLLSIADLNQQEIRTILDLAADLKSGKKQFQTNKTLGLLFYKASTRTRVSFSVAMYQLGGNVIDLNPSRTQVGRGEPLQDTARVLDRYLDILAIRTFAQEDIQTFADYSDIPIINALTDLEHPCQILADLQTIEESFGSLEGITMTYLGDGNNVAHSLLLGGVLMGMNVRIATPEGYEPNKDIIKQAQALAKKSEQVVITHNAKEAVENTQVLYTDVWASMGQEEESATREPIFQPYQINEELLGIADKSAIVLHCLPAYRGKEITEEVMEGNQSRIWDEAENRMHAQKALMACLLGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4W7</accession>
    <name>K9Z4W7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219187.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1344"/>
    <dbReference type="EnsemblBacteria" id="AFZ53458">
        <property type="protein sequence ID" value="AFZ53458"/>
        <property type="gene ID" value="Cyan10605_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1344"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1418"/>
    <dbReference type="eggNOG" id="COG3304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120384_1_0_3"/>
    <dbReference type="OMA" id="GVYALWP"/>
    <dbReference type="OrthoDB" id="1806532at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="125" mass="13572" checksum="6BD3A9FCF3D671A6" modified="2013-03-06" version="1">MTLLGNIIWLIFGGFVSGLGYIIGGLSLCLTIIGIPFGLQTIKIGIATLTPFGKINVVAEDSSNLLTMIFNVIWVILFGWEIALSHLVHGLILAITIIGIPFAQQHFKLIPIALFPFGRNLQDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z4X5</accession>
    <name>K9Z4X5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219904.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ54179">
        <property type="protein sequence ID" value="AFZ54179"/>
        <property type="gene ID" value="Cyan10605_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2090"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2221"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101320_2_2_3"/>
    <dbReference type="OMA" id="YRRKAIN"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="16019" checksum="9B5FFC740F740636" modified="2013-03-06" version="1">MSSNYNKGFRSVYKLTAHVVLVTKYRKKAISEKILLRLKEIFTETLIKWECDLVEFNGESDHVHLLIDYKPDISLSKLIANLKTVSSRLIRRDFPELASKYFDNKPYFWTGAYFVASCGGVTVSQLKKYVETQKTPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z537</accession>
    <name>K9Z537_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thermitase</fullName>
            <ecNumber evidence="8">3.4.21.66</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_1755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.66" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219584.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1755"/>
    <dbReference type="EnsemblBacteria" id="AFZ53857">
        <property type="protein sequence ID" value="AFZ53857"/>
        <property type="gene ID" value="Cyan10605_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1755"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1863"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_4_3"/>
    <dbReference type="OMA" id="PYSNFGA"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07484">
        <property type="entry name" value="Peptidases_S8_Thermitase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045986">
        <property type="entry name" value="DUF5942"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017295">
        <property type="entry name" value="Pept_S8A_subtilisin_cyanobac-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034084">
        <property type="entry name" value="Thermitase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19366">
        <property type="entry name" value="DUF5942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037851">
        <property type="entry name" value="Subtilisin_cyano"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="135"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5942" evidence="7">
        <location>
            <begin position="398"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="585" mass="63185" checksum="0C8DF975A18367EC" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z544</accession>
    <name>K9Z544_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="7" type="synonym">rps20</name>
        <name evidence="8" type="ordered locus">Cyan10605_1566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219402.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1566"/>
    <dbReference type="EnsemblBacteria" id="AFZ53675">
        <property type="protein sequence ID" value="AFZ53675"/>
        <property type="gene ID" value="Cyan10605_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1566"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1663"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_5_0_3"/>
    <dbReference type="OMA" id="KRCFSAC"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ53675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="99" mass="11137" checksum="525916D126B003A7" modified="2013-03-06" version="1">MANSKSALKRIQINERNRLRNKAYKSAVKTLMKKYFQAVEAYATSPSDELKQAVQTCQSAAYSKIDKAVKRGVYHRNNGARKKARLAKAFSKINQAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z571</accession>
    <name>K9Z571_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220014.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2203"/>
    <dbReference type="EnsemblBacteria" id="AFZ54289">
        <property type="protein sequence ID" value="AFZ54289"/>
        <property type="gene ID" value="Cyan10605_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2203"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2341"/>
    <dbReference type="eggNOG" id="COG1563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336391_0_0_3"/>
    <dbReference type="OMA" id="PYHALVI"/>
    <dbReference type="OrthoDB" id="1909852at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="194" mass="22305" checksum="F36B3AF628D9FB49" modified="2013-03-06" version="1" precursor="true">MDNLYIYLIMALLPISALMLMIQVNPYQALVIRGILGAIAVLSYIILGAADVALTEGLMGTMLGVALYIIAVRSSFVMRLGVIQEDKKNTEKDPNFDNIKNQIKQVINNFYLRLELVYYSEQELLKNSFNDKKIHGYILTSNQLDKKYLLNIRTKRLFDILQQGIKSEQLLIGYQMDIKENQDQYLEYVKNNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5B5</accession>
    <name>K9Z5B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219472.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1638"/>
    <dbReference type="EnsemblBacteria" id="AFZ53745">
        <property type="protein sequence ID" value="AFZ53745"/>
        <property type="gene ID" value="Cyan10605_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1638"/>
    <dbReference type="eggNOG" id="ENOG5033GUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193486_0_0_3"/>
    <dbReference type="OrthoDB" id="1989447at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7873" checksum="F33CF898203BC1BC" modified="2013-03-06" version="1">MTKLQLIQAEIETLTSDDFTYLKNWINELDTQQWEKQIEQDSNDGKLDFLIEEALLEKTKNQLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5H8</accession>
    <name>K9Z5H8_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ordered locus">Cyan10605_2315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220123.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2315"/>
    <dbReference type="EnsemblBacteria" id="AFZ54399">
        <property type="protein sequence ID" value="AFZ54399"/>
        <property type="gene ID" value="Cyan10605_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2315"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2459"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_3"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ54399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="480" mass="52297" checksum="51DBF0CBBD5DF433" modified="2013-03-06" version="1">MFDALAERLEDTWKKLRGQGKISQSNIQEALQEVRKALLEADVNFQVVKSFVAEVEKNALGAEVISGVNPQQQFIKIVYDELVKVMGESNAPLAEADKPPRVVLMAGLQGAGKTTATAKLALYLQKQKRSCLMVATDVYRPAAIQQLITLGTQISVPVFELGTGANPVDIARQGLEEAKNKGIDTVIIDTAGRLQIDQEMMAELAQVKDAVNPDEVLLVVDSMTGQEAANVTRSFHEEIGITGAILTKMDGDSRGGAALSIRTISGQPIKFIGVGEKVEALEPFYPDRMASRILNMGDIVTLVEKAQEELDIADVEKMQKKMMEAKFDFNDFLKQMRLLKNMGSFAGVMKLIPGMNKLGAGALEQGEVQLKRTETMINSMTKEERANPQLLAQSPSRRRRVAKGSGHQEKDVSRLVSDFTRMRSMMQQMSMGGGLPGMGGMPGMGGLGGLLGGGMPRPGYRNQPKKKAKKTKKKRGFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5I3</accession>
    <name>K9Z5I3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photosystem II CP47 reaction center protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PSII 47 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein CP-47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psbB</name>
        <name evidence="11" type="ordered locus">Cyan10605_2320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.</text>
    </comment>
    <comment type="cofactor">
        <text evidence="9">Binds multiple chlorophylls. PSII binds additional chlorophylls, carotenoids and specific lipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Cyanobacterial PSII is composed of 1 copy each of membrane proteins PsbA, PsbB, PsbC, PsbD, PsbE, PsbF, PsbH, PsbI, PsbJ, PsbK, PsbL, PsbM, PsbT, PsbX, PsbY, PsbZ, Ycf12, at least 3 peripheral proteins PsbO, PsbU, PsbV and a large number of cofactors. It forms dimeric complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cellular thylakoid membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PsbB/PsbC family. PsbB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220128.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2320"/>
    <dbReference type="EnsemblBacteria" id="AFZ54404">
        <property type="protein sequence ID" value="AFZ54404"/>
        <property type="gene ID" value="Cyan10605_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2320"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2464"/>
    <dbReference type="eggNOG" id="ENOG502Z7TN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028227_2_0_3"/>
    <dbReference type="OMA" id="MLAAIWH"/>
    <dbReference type="OrthoDB" id="174499at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01495">
        <property type="entry name" value="PSII_PsbB_CP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017486">
        <property type="entry name" value="PSII_PsbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33180">
        <property type="entry name" value="PTHR33180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="SSF161077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03039">
        <property type="entry name" value="PS_II_CP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="7 9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ54404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="510" mass="56184" checksum="FBE2737B5C9E383B" modified="2013-03-06" version="1">MGLPWYRVHTVVINDPGRLIAVHLMHTALVAGWAGSMALYELAVFDPSDPVLNPMWRQGMFVLPFMARLGVTGSWGGWSVTGETGVNPGFWSFEGVAIAHIVLSGLLFLAAVWHWVFWDLELFTDPRTGEPALDLPKMFGIHLFLSGLLCFGFGAFHLTGLWGPGMWVSDPYGLTGHVQPVAPEWGPAGFNPFNPGGVVAHHIAAGIVGIIAGLFHLSVRPPERLYKALRMGNIETVLSSSIAAVFFAAFVVAGTMWYGNATTPVELFGPTRYQWDQGYYQQEIQRRVQASIADGATPEEAWEAIPEKLAFYDYVGNSPAKGGLFRTGAMNKGDGIAQGWLGHPVFQDKEGRELTVRRLPNFFETFPVVLTDADGVVRADIPFRRAESALSIEQTGVTVSFLGGELNGQTFSDPLDVKRYARKAQLGEPFEFDTETLNSDGVFRTSTRGWFAFGHACFALLFFFGHIWHGARTLFRDVFAGIDPDLDPEQVEWGMFQKVGDKSTRRAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5K2</accession>
    <name>K9Z5K2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Cyan10605_2383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="8"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220190.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2383"/>
    <dbReference type="EnsemblBacteria" id="AFZ54466">
        <property type="protein sequence ID" value="AFZ54466"/>
        <property type="gene ID" value="Cyan10605_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2383"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2529"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029435_0_0_3"/>
    <dbReference type="OMA" id="RENNITW"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010802">
        <property type="entry name" value="DUF1400"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07176">
        <property type="entry name" value="DUF1400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938676" description="Poly(ethylene terephthalate) hydrolase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1400" evidence="11">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="560" mass="62564" checksum="8963F1ACBC11817F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Q6</accession>
    <name>K9Z5Q6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219632.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1803"/>
    <dbReference type="EnsemblBacteria" id="AFZ53905">
        <property type="protein sequence ID" value="AFZ53905"/>
        <property type="gene ID" value="Cyan10605_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1803"/>
    <dbReference type="HOGENOM" id="CLU_1841805_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="139" mass="17066" checksum="822087E5D477420E" modified="2013-03-06" version="1">MKEQRIKKRVTTYFKEEDLIKMDDFCKKHNIKRTEFLERALNHFVNSIENDLNLLSLAYYSVSDCNWLRLAVDDFLYDLWDSYYQDEDIEPDKILEEENVKWHEYPEMIEKYGFEKVVSILIKFISAENNLRFKRHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R2</accession>
    <name>K9Z5R2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2407"/>
    <dbReference type="EnsemblBacteria" id="AFZ54489">
        <property type="protein sequence ID" value="AFZ54489"/>
        <property type="gene ID" value="Cyan10605_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2407"/>
    <dbReference type="HOGENOM" id="CLU_3151897_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="48" mass="5369" checksum="D32B0FD05F332A9A" modified="2013-03-06" version="1">MKGLRRLESPIVSYSFCGNILIQVQSAINVVLSNEELWMSAKSDQSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5R4</accession>
    <name>K9Z5R4_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_1987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219807.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1987"/>
    <dbReference type="EnsemblBacteria" id="AFZ54082">
        <property type="protein sequence ID" value="AFZ54082"/>
        <property type="gene ID" value="Cyan10605_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1987"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2108"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_2_3"/>
    <dbReference type="OMA" id="YMADSIV"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="523"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="579"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="490"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="852" mass="94717" checksum="8CB9D3B2BF50283F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5T7</accession>
    <name>K9Z5T7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219465.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1631"/>
    <dbReference type="EnsemblBacteria" id="AFZ53738">
        <property type="protein sequence ID" value="AFZ53738"/>
        <property type="gene ID" value="Cyan10605_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1631"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1731"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_3"/>
    <dbReference type="OMA" id="KCRFHYD"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ53738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="84" mass="10354" checksum="D3EDBD36F2224DEA" modified="2013-03-06" version="1">MKISFLEDGWHDYLYWQSQDKKILKRINQIIKDIKRNPFDGIGKPEPLKFDFSGLWSRRINQEHRLIYQVLDDEVIIIQCRYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5U2</accession>
    <name>K9Z5U2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219470.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1636"/>
    <dbReference type="EnsemblBacteria" id="AFZ53743">
        <property type="protein sequence ID" value="AFZ53743"/>
        <property type="gene ID" value="Cyan10605_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1636"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088683_0_0_3"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="29205" checksum="A78E6C9DA52CF469" modified="2013-03-06" version="1">MKVIIIGGNGFVGSAYKRFCEKNSIDHLIVNRHNYHDYIGTKADILINANGNSKKFLATQEPLVDFDASVRSLRQSLIDFPCDKYVFLSSCDVYSDCSSYESTKEDVVIDISKQSPYGFHKYLAELCVQHCHHDWLIFRMGGFVGEHLKKNAIFDILWGDRLWLHPESKLQYINTDIAAMRVMEIIKKGYSQEIFNLCGNGVIELQEVLNMTNREVEINTEAKPVHYEVNIDKIQSVTDIPSTRDAVIDFVQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5V2</accession>
    <name>K9Z5V2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220247.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2443"/>
    <dbReference type="EnsemblBacteria" id="AFZ54524">
        <property type="protein sequence ID" value="AFZ54524"/>
        <property type="gene ID" value="Cyan10605_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2443"/>
    <dbReference type="HOGENOM" id="CLU_186198_1_0_3"/>
    <dbReference type="OMA" id="WLEATNR"/>
    <dbReference type="OrthoDB" id="2075887at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021481">
        <property type="entry name" value="DUF3134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11332">
        <property type="entry name" value="DUF3134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="83" mass="9752" checksum="9FB1A4E8C42FB57A" modified="2013-03-06" version="1">MKNPALRKEKRYEPAPVIPLKQDGSLLDWLEANDRIIYREEREDRLVETAVTEDEEISDLIEGEEDEFDPDELDDFDDEADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z5Y9</accession>
    <name>K9Z5Y9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219715.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1891"/>
    <dbReference type="EnsemblBacteria" id="AFZ53990">
        <property type="protein sequence ID" value="AFZ53990"/>
        <property type="gene ID" value="Cyan10605_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1891"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2007"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172624_0_0_3"/>
    <dbReference type="OMA" id="RQFTEQV"/>
    <dbReference type="OrthoDB" id="2022753at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="108" mass="12380" checksum="9CD9D605F835592D" modified="2013-03-06" version="1">MTNPINDFYYLSKALTEVLTEKAEDSLTHILSDIGKFDAETRQRLQEFAQEVKARAEKAKQQSSNTDTTITVEANTEVDLQELLDELRAEIARLKAELNNYRQNNEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z613</accession>
    <name>K9Z613_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219740.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1917"/>
    <dbReference type="EnsemblBacteria" id="AFZ54015">
        <property type="protein sequence ID" value="AFZ54015"/>
        <property type="gene ID" value="Cyan10605_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1917"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2035"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_3"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="723" mass="81616" checksum="4C5AFC5E1BF6EDE0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z614</accession>
    <name>K9Z614_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_2503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220307.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2503"/>
    <dbReference type="EnsemblBacteria" id="AFZ54584">
        <property type="protein sequence ID" value="AFZ54584"/>
        <property type="gene ID" value="Cyan10605_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2503"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_2_0_3"/>
    <dbReference type="OMA" id="WILLSHG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ54584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="248" mass="28042" checksum="D230C2A4C82378C3" modified="2013-03-06" version="1">MINSSAYLLVVHGSRNSFYAQQLRDLTFSVRQKLDLLQVTCDLDIAYLELGNQSLSEKIIEFGNQLERKGYKNLKVLPLFLLSGTHVINDIPFEVEVSRQKCSLQIEILPHLGRSLSLISLLCAEYERQENLDHHKDSSIERILFCHGTSLQKGNEEIEGLAGKINAHVAYWSIKPNLHSVIAKLALNDPPKIMIMPYFLFTGKIIDAIASEVEELQKELSCELKLLPPLTQIDGFSDIIVNILLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z642</accession>
    <name>K9Z642_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophycocyanin alpha subunit apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_1949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cellular thylakoid membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phycobiliprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219770.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1949"/>
    <dbReference type="EnsemblBacteria" id="AFZ54045">
        <property type="protein sequence ID" value="AFZ54045"/>
        <property type="gene ID" value="Cyan10605_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1949"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2071"/>
    <dbReference type="eggNOG" id="ENOG502Z7RG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104219_2_0_3"/>
    <dbReference type="OMA" id="GGQLFQK"/>
    <dbReference type="OrthoDB" id="1461468at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030089">
        <property type="term" value="C:phycobilisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012128">
        <property type="entry name" value="Phycobilisome_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00502">
        <property type="entry name" value="Phycobilisome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000081">
        <property type="entry name" value="Phycocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0042">Antenna complex</keyword>
    <keyword evidence="3 4" id="KW-0089">Bile pigment</keyword>
    <keyword evidence="2 4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-0605">Phycobilisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="161" mass="17412" checksum="5A9B66B674EC03B1" modified="2013-03-06" version="1">MSIVTKSIVNADAEARYLSPGELDRIKAFVTSGEARLRIAETLTGARERIVKEAGDRLFQKRPDVVSPGGNAYGEEMTATCLRDMDYYLRLISYGVVAGDVTPIEEIGLVGVKEMYKSLGTDVGAVAQSVREMKEVATALMSAEDAAEAGTYFDYVIGAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z648</accession>
    <name>K9Z648_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2539"/>
    <dbReference type="EnsemblBacteria" id="AFZ54619">
        <property type="protein sequence ID" value="AFZ54619"/>
        <property type="gene ID" value="Cyan10605_2539"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2539"/>
    <dbReference type="HOGENOM" id="CLU_1472874_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20864" checksum="0A15EEE3675BEA3A" modified="2013-03-06" version="1" precursor="true">MKYLTKYIKFFGVKSLILILSLSYFNDVKALPPEQILPERIEDLEYLGGAWIPLNNSEAMYGGNLDEGSYWYHLAQGKNTVFLILQQLQARTSDGKPIMKNLDVVVVPELAKQSTYRIMRGVQENCIYPNGQKLQDSRILIIVKYHQDTATPIRSFLANLQTEKWETPPASTIKGLVCQLEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z671</accession>
    <name>K9Z671_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219630.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53903">
        <property type="protein sequence ID" value="AFZ53903"/>
        <property type="gene ID" value="Cyan10605_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1801"/>
    <dbReference type="HOGENOM" id="CLU_1737507_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="150" mass="17038" checksum="9E2471248DE7CFCE" modified="2013-03-06" version="1">MINVPHESLDLNYIFGDYLAEYIKESAKEIPTNPDAIVTILLPVLASVIGTRSRIIVNPNTRYIVPFIIRSMIFAYIVTKCQEGMLNSQLLKIFELLKKKGEITSTDVKRFIWEFKSVPNGDINELLLSLVELSKAQQIPTKKGIKIKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6A8</accession>
    <name>K9Z6A8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219997.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2186"/>
    <dbReference type="EnsemblBacteria" id="AFZ54272">
        <property type="protein sequence ID" value="AFZ54272"/>
        <property type="gene ID" value="Cyan10605_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2186"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2322"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_3"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="218"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="533" mass="60367" checksum="AC3F1611FE0F18A5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6H6</accession>
    <name>K9Z6H6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmosensitive K channel His kinase sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_2262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220071.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2262"/>
    <dbReference type="EnsemblBacteria" id="AFZ54347">
        <property type="protein sequence ID" value="AFZ54347"/>
        <property type="gene ID" value="Cyan10605_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2262"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2402"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_4_3"/>
    <dbReference type="OMA" id="LNVEREN"/>
    <dbReference type="OrthoDB" id="684949at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KdpD" evidence="4">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="231"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ54347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="41245" checksum="DCEC5F02D5F691DB" modified="2013-03-06" version="1">MLRKQGKHKIFIGMAPGVGKTYKMLQDANILKKQGIDVVIGLLETHNRQETLLQADGLEIIPRKFISQDNLTLTEMDTEAIINRHPQLVLIDELAHTNIPNSRYQKRYQDVEEILKAGIDVYSTVNIQHLESLNDLIAKITGVVVRERIPDRILDEADQVVVIDVTPETLEERLLAGKIYASNKIEQSLQNFFQRKNLIALRELALREVADTVEEEGEESIPFAQSYLIQERVLVCVSTYPNSLRLLRRGARLANYMNAPLFVLFVKNPDHFLSKTEALHIETCQQLCRDFEGTFLRVEDYNVASVIALIAEQEKITQIVIGESRQSRWKQLLRGSFTQKLMRLIWKKQIDLHIIATNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6M9</accession>
    <name>K9Z6M9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219783.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1963"/>
    <dbReference type="EnsemblBacteria" id="AFZ54058">
        <property type="protein sequence ID" value="AFZ54058"/>
        <property type="gene ID" value="Cyan10605_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1963"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2084"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012650_0_0_3"/>
    <dbReference type="OMA" id="ITKAFAM"/>
    <dbReference type="OrthoDB" id="1892293at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="120" mass="13830" checksum="2D10C5755E74653B" modified="2013-03-06" version="1">MIKNDKIIPNPYDVLEVSPAASHAEIVKAFAMAMKKKKYNPKQIAEARKQLMDNQQRLIADFLRPNLPLIQRFKNHDLSALNEPIPVINLVPEFDNLDQAYQESEIISERDRTLGKQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6U4</accession>
    <name>K9Z6U4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2792"/>
    <dbReference type="EnsemblBacteria" id="AFZ54859">
        <property type="protein sequence ID" value="AFZ54859"/>
        <property type="gene ID" value="Cyan10605_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2792"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2967"/>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193875_0_0_3"/>
    <dbReference type="OMA" id="DFFPDWG"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="260" mass="30289" checksum="91961F79F47F20D4" modified="2013-03-06" version="1">MALSEAIFFDSCNYLYISSIAIIFIIMGNLVDELKRDIQYQHGMNACLNCGICTAVCPAAEVYEYSPREVMNICHTEDEEWLIDLLKSDKIWFCGQCYSCKPRCPRGNSTADVILALRRLSVRHGYFAESEKGRQQLFAKRVFGENMLKRGYTLTAENITPEHFPELGDNWEYYFEHMKEMREWWDVPMDKENSAGSHRIIPEKDMDELRAIYKATGAIELMEAVEKGMEKKLGSKEEVERYWQNWVETADSRNYEMKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y2</accession>
    <name>K9Z6Y2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220621.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2832"/>
    <dbReference type="EnsemblBacteria" id="AFZ54899">
        <property type="protein sequence ID" value="AFZ54899"/>
        <property type="gene ID" value="Cyan10605_2832"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2832"/>
    <dbReference type="HOGENOM" id="CLU_2878351_0_0_3"/>
    <dbReference type="OrthoDB" id="1933588at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="63" mass="7347" checksum="355FD2C5932C917B" modified="2013-03-06" version="1">MNNLDYDNLSIDELAMAINLDKEERELLDSIENDEWVSISNEKEEIGVLKSMINKFTKSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z6Y4</accession>
    <name>K9Z6Y4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="13" type="ordered locus">Cyan10605_2059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219873.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2059"/>
    <dbReference type="EnsemblBacteria" id="AFZ54148">
        <property type="protein sequence ID" value="AFZ54148"/>
        <property type="gene ID" value="Cyan10605_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2059"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2188"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064900_0_0_3"/>
    <dbReference type="OMA" id="EEWCRFG"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01327">
        <property type="entry name" value="TMP_synthase_cyanobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041397">
        <property type="entry name" value="ThiD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016229">
        <property type="entry name" value="TMP_synthase_cyanobac_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17792">
        <property type="entry name" value="ThiD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000512">
        <property type="entry name" value="TMP_PPase_Cyanobac_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiD2" evidence="12">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="143"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Unknown" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine-phosphate synthase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="169"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="337" mass="38047" checksum="20966B719374E68A" modified="2013-03-06" version="1">MEQKQAIYRILDANLDRAREGLRIIEEWCRFGLNNQTMAESCKQMRQELSQWHSPEIRAARDTVNDVGTTLTHPKEEKRENLDSVLLANLCRIQEALRVLEEYSKLINGKFALTMKQMRYQVYTLESQLMNKNNHQLLSQSSLYLVTSPVENLYEVVESALQGGLKLVQYRHKDETDVVRYEQASKLKQLCHKYNALFLVNDRIDLALAVNADGVHLGQTDLPISVARQLLGKDKIIGKSTTNPEEMKNAIADQVDYIGVGPVYETPTKAGKKAAGLEYVRYAQENASIPWFAIGGIDETNIEDVVRAGATNVAVVRAIMVADNPKEVTQNLLKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z708</accession>
    <name>K9Z708_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zeta-carotene desaturase</fullName>
            <ecNumber evidence="5">1.3.5.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">9,9'-di-cis-zeta-carotene desaturase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol</text>
            <dbReference type="Rhea" id="RHEA:30955"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:48716"/>
            <dbReference type="ChEBI" id="CHEBI:62466"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carotenoid biosynthesis; lycopene biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the zeta carotene desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.6" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220074.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2265"/>
    <dbReference type="EnsemblBacteria" id="AFZ54350">
        <property type="protein sequence ID" value="AFZ54350"/>
        <property type="gene ID" value="Cyan10605_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2265"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2406"/>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022687_1_1_3"/>
    <dbReference type="OMA" id="MLTIFMM"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="UniPathway" id="UPA00803"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052887">
        <property type="term" value="F:7,9,9'-tricis-neurosporene:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052886">
        <property type="term" value="F:9,9'-dicis-carotene:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016719">
        <property type="term" value="F:carotene 7,8-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014103">
        <property type="entry name" value="Zeta_caro_desat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02732">
        <property type="entry name" value="zeta_caro_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="483" mass="53735" checksum="C84E2B4BFA5E2A61" modified="2013-03-06" version="1">MRVAIVGAGLAGLATAIELVDAGCEVEIFESRPFVGGKVGSWVDNDGNHIEMGLHVFFGCYYNLFALMEKVGAIENLRLKEHTHTFINQGGRVGELDFRFPTGAPFNGLKAFFTTSQLSTVDKIANSLALGTSPIVRGLIDFHGAMRQIRNLDSISFADWFRKHGGNQGSLDKMWNPIAYALGFIDTENISARCMLTIFQFFAAKTEASVLRMLEGSPHEYLHKPIINYLESRGVKIHTRRRVREILYQEGDDTTVTGLLIAKGETEEVIIADTYVCACDVPGIQKLIPDGWRKWSEFDNIYKLTAVPVATVQLRFDGWVTELNDPQKRRQLEKAEGIDNLLYTADADFSCFSDLALSSPADYYREGQGSLLQLVLTPGDPFIKESNENIANHVLKQVHELFPSSRELNMTWYSVVKLAQSLYREAPGMDVYRPSQATPISNFFLAGSYTQQDYIDSMEGATISGLQAARAILKSNQKVAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7D6</accession>
    <name>K9Z7D6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit sodium/proton antiporter, MrpB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Cyan10605_2202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220013.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2202"/>
    <dbReference type="EnsemblBacteria" id="AFZ54288">
        <property type="protein sequence ID" value="AFZ54288"/>
        <property type="gene ID" value="Cyan10605_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2202"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2340"/>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069132_3_0_3"/>
    <dbReference type="OMA" id="VFIRYRG"/>
    <dbReference type="OrthoDB" id="1836204at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ54288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="220" mass="23420" checksum="A8CD706E198D429A" modified="2013-03-06" version="1" precursor="true">MKILYIIASLAMFIKILVMPNTMAELSEMSIVEMVVEDTGVPNAVSGIIFRNRLYDTIFEVIVFTIAILGVGFLLSNEQPTTVVYQFTDQPSIVLARLGATITALVTTELAIRGHLSPGGGFAAGVAGGTAIGLIAITSSSQTMEKVYKRFSAATLEKVSVLLFIILAIATLTGIELPHGNLGYLISGGSIPLLNIIVALKVALGSWAAILLFVRYRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7M9</accession>
    <name>K9Z7M9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine synthetase inactivating factor IF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220895.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3125"/>
    <dbReference type="EnsemblBacteria" id="AFZ55176">
        <property type="protein sequence ID" value="AFZ55176"/>
        <property type="gene ID" value="Cyan10605_3125"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3125"/>
    <dbReference type="eggNOG" id="ENOG50347QB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205891_0_0_3"/>
    <dbReference type="OMA" id="RNRQQSM"/>
    <dbReference type="OrthoDB" id="2052750at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7603" checksum="9485ED3EE58CBD1F" modified="2013-03-06" version="1">MNTNQKSRALMMRHDKMIRNRQQSMLGRVAGEIGMDVNNTEYYENLKSAPLSNFARSYDRSSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U6</accession>
    <name>K9Z7U6_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family. Ycf83 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220917.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3148"/>
    <dbReference type="EnsemblBacteria" id="AFZ55199">
        <property type="protein sequence ID" value="AFZ55199"/>
        <property type="gene ID" value="Cyan10605_3148"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3148"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3355"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_3"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031108">
        <property type="entry name" value="ISCA_plant_cyanobact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47265">
        <property type="entry name" value="PTHR47265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="119" mass="13124" checksum="EBE05AA4855D8E16" modified="2013-03-06" version="1">MTQAVTGSEKGIQISEKALKHLLTLKEQQGNQDLCLRVGVRQGGCSGMSYMMDFENINNVTEHDDIFDYDGFKIICDRKSLLYLYGLMLDYSDAMIGGGFQFTNPNATQTCGCGKSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7U8</accession>
    <name>K9Z7U8_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2391"/>
    <dbReference type="EnsemblBacteria" id="AFZ54473">
        <property type="protein sequence ID" value="AFZ54473"/>
        <property type="gene ID" value="Cyan10605_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2391"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047522_1_2_3"/>
    <dbReference type="OMA" id="LMVGESW"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="340" mass="39754" checksum="251C2A3EEA68B87C" modified="2013-03-06" version="1">MKNLPLVRANSLFPLLKFLHENSIPLENFFYKSTIPENIFSQPENLLSLHQVFNAIDSFAHRQGIDYLGVLASEKLEIEDLGLFGKILRQSFTGYDLLRTIITLLSKTYSSGVRVWLKEENDVIWFNHQYPNLQYDKNRQGGYYAFFLHFQAIRSMIGFDWYPTDLYFQGQTVKGLSDIDLFSRSRIHFNQRYNSIGISKNVLYLPLKRESQNIDYNEEQDLYEHLISSSPDVDFSKALQQLIRSQLLGGNIQIQTIADAIGMSKRSLQRCLGDRGLSYFHLLDQVRFQLAVEWLKDTNIPIGEIAFELHYSEINSFTRSFKRWTGVTPSDYRYRLHSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Y2</accession>
    <name>K9Z7Y2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Cyan10605_3201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220967.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3201"/>
    <dbReference type="EnsemblBacteria" id="AFZ55249">
        <property type="protein sequence ID" value="AFZ55249"/>
        <property type="gene ID" value="Cyan10605_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3201"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3412"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_3"/>
    <dbReference type="OMA" id="YTDLHLI"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="486"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="711"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="870"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ55249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="989" mass="110941" checksum="6B760AFD975E2D56" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7Z4</accession>
    <name>K9Z7Z4_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_2605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220403.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2605"/>
    <dbReference type="EnsemblBacteria" id="AFZ54680">
        <property type="protein sequence ID" value="AFZ54680"/>
        <property type="gene ID" value="Cyan10605_2605"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2605"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2767"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_3"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ54680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="107" mass="11964" checksum="F6BC90F46E612E2E" modified="2013-03-06" version="1">MSEVTEVKEADFKEVVLDSELPVLVDFWAPWCGPCRMVAPVVEEIAQQYEGKVKVVKLNTDENPQIASQYGIRSIPTLMVFKDGEKKDMVVGAVPKTTLSNTLEKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z839</accession>
    <name>K9Z839_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220453.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2656"/>
    <dbReference type="EnsemblBacteria" id="AFZ54730">
        <property type="protein sequence ID" value="AFZ54730"/>
        <property type="gene ID" value="Cyan10605_2656"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2656"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2821"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969133_0_0_3"/>
    <dbReference type="OMA" id="WFIREIM"/>
    <dbReference type="OrthoDB" id="932506at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="116"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="289" mass="34249" checksum="F57D8BE81A25A3ED" modified="2013-03-06" version="1">MTRKNQAVTLSIGEREKKALENLALEFGKTWGDKPNVSKLIKAIALKELKITINDDWNSQRIETLEKARKLLLDLGFILEAEEIGRILRERSELNIFFRDEIEQFLAKPKPLWRKNIENFIQKQQPFKLTYQDASDNLLNFTVIHGQLKIIEKHQYLVCTCRETEGNDDITELKHNWTLRLDRIQEAVVNRVELSWQPELDMIEAEFKVFGNLAFAYGKEEVKIDDTFKGEIEGSPPHRLIRRKVWSSFWFFREIARYWDSCKIISPDSLREKFYEKLLNLNHLYSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z859</accession>
    <name>K9Z859_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_3339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221099.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3339"/>
    <dbReference type="EnsemblBacteria" id="AFZ55381">
        <property type="protein sequence ID" value="AFZ55381"/>
        <property type="gene ID" value="Cyan10605_3339"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3339"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3556"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_3"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ55381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="324" mass="36548" checksum="AFDD7F38089DBEE3" modified="2013-03-06" version="1">MLLYRPRRLRRTEALRSMVQENHLTVNDLIYPIFVMEGENIKQEIPSMPNCYRYSLDLLLKEVQEIYDLGINSIALFPLIEENKKDNEGKESYNPEGLVQRSIKTIKAEIPKITVITDIALDPYSVYGHDGIVRDGEILNDETVEVLVKMALSHAEAGADMVAPSDMMDGRIGAIRQALDKEGWINTGILAYSAKYASAYYGPFRDALESAPQFGDKKTYQMDYANGKEAIKEVALDIKEGADMVMIKPALAYLDIIRRVRDYTNLPVVAYNVSGEYSMIKAASQRGWIDEDKVVLETLTSMKRAGADLILTYFAKQVAQQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z871</accession>
    <name>K9Z871_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="6" type="ordered locus">Cyan10605_3298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221062.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3298"/>
    <dbReference type="EnsemblBacteria" id="AFZ55344">
        <property type="protein sequence ID" value="AFZ55344"/>
        <property type="gene ID" value="Cyan10605_3298"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3298"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3513"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_3"/>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="252"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="494" mass="55160" checksum="328871A5057BEDF5" modified="2013-03-06" version="1">MKAIMVVGTASHTGKSSLVTALCRLMLRKGWLVTPFKGQNMALNAYVTATTGEIGYAQALQAWAAKTIPRVEMNPILLKPQGNMTSQVIIKGESVGVTNAKEYYENYFEKGWQAIIESLDILSREFDLIICEGAGSPVEVNLKHRDLTNMRIAKHLKADTILIADIEKGGVFAHIVGTLELLEPEERSLVKGIVINKFRGDKSILDPGLKWLEEYTKIPVLGVIPWFDSHLPAEDSLGLIERPSRKINYQLKIAVIKLPRISNFTDFDPLEAEESILIEYIEPDQPLGYPDAVIIPGTKTTIPDLIVLENTGMKAQIQEYVESGGTVFGICGGFQMLGHQVLDPDHLENLNESCQGLDLLPIQTTLKVEKITRQREVTANYPQKGLPVDGYEIHQGYTEVIPALSRQRKIGYNNLFDDPTLGLVNDNQSVWGCYLHGIFDNGAWRRAWLNTLRLKRGLPSLPTGIANYRQQREKILDSLADLIDEHLDLTPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z888</accession>
    <name>K9Z888_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Cyan10605_2718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2718"/>
    <dbReference type="EnsemblBacteria" id="AFZ54790">
        <property type="protein sequence ID" value="AFZ54790"/>
        <property type="gene ID" value="Cyan10605_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2718"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376733_0_0_3"/>
    <dbReference type="OMA" id="EIRLWQY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="475"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ54790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="726" mass="82354" checksum="1B68584382EB3D59" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z892</accession>
    <name>K9Z892_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_2723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220518.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2723"/>
    <dbReference type="EnsemblBacteria" id="AFZ54795">
        <property type="protein sequence ID" value="AFZ54795"/>
        <property type="gene ID" value="Cyan10605_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2723"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2889"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015624_0_0_3"/>
    <dbReference type="OMA" id="QKRLIWA"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="6">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="ResIII" evidence="5">
        <location>
            <begin position="241"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="7">
        <location>
            <begin position="613"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="803" mass="92771" checksum="E055CED3E3F265FF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8B2</accession>
    <name>K9Z8B2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_2533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
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            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220336.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2533"/>
    <dbReference type="EnsemblBacteria" id="AFZ54613">
        <property type="protein sequence ID" value="AFZ54613"/>
        <property type="gene ID" value="Cyan10605_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2533"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2688"/>
    <dbReference type="eggNOG" id="ENOG5033ECU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202383_0_0_3"/>
    <dbReference type="OMA" id="FIAVQIF"/>
    <dbReference type="OrthoDB" id="2067554at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="66" mass="7750" checksum="079075EDCC84A044" modified="2013-03-06" version="1">MKVWLVSFFILFALTQFIMWLKNFFMPLPLYIFGGAFLAIASNYDQNISKFISHKTQTFFGSKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C0</accession>
    <name>K9Z8C0_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221159.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3399"/>
    <dbReference type="EnsemblBacteria" id="AFZ55441">
        <property type="protein sequence ID" value="AFZ55441"/>
        <property type="gene ID" value="Cyan10605_3399"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3399"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_2_0_3"/>
    <dbReference type="OMA" id="FWMKNVP"/>
    <dbReference type="OrthoDB" id="1934378at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="183" mass="20442" checksum="5AB0B56EB78769C8" modified="2013-03-06" version="1" precursor="true">MVNFPKILSYPLVISLCFFVSSCDTGENSLSQAQNEENISTLSIADVSSPQNLPINAILSIDNQQIELEVAETPEQQQLGLMFRTDLPPDRGMLFLFQPPTIVNFWMKNVFISLDMLFVRDGVVQNIAHNVPPCTKEPCPLYSSEVEIDQVIELAGGRAKELNIKKGDRISVEFLPSENSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8C9</accession>
    <name>K9Z8C9_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Cyan10605_2767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">PCC 10605</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220557.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2767"/>
    <dbReference type="EnsemblBacteria" id="AFZ54835">
        <property type="protein sequence ID" value="AFZ54835"/>
        <property type="gene ID" value="Cyan10605_2767"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2767"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2938"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_3"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="217"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="414"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="12">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ54835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="622" mass="67435" checksum="78771AF1D852128A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J1</accession>
    <name>K9Z8J1_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide adenylyltransferase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_3480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221234.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3480"/>
    <dbReference type="EnsemblBacteria" id="AFZ55516">
        <property type="protein sequence ID" value="AFZ55516"/>
        <property type="gene ID" value="Cyan10605_3480"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3480"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3706"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_5_0_3"/>
    <dbReference type="OMA" id="ILCHTTA"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="905" mass="102488" checksum="2E09666BB9144ACA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8J2</accession>
    <name>K9Z8J2_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">Cyan10605_3439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221197.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3439"/>
    <dbReference type="EnsemblBacteria" id="AFZ55479">
        <property type="protein sequence ID" value="AFZ55479"/>
        <property type="gene ID" value="Cyan10605_3439"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3439"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3664"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_0_3"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ55479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="255" mass="28130" checksum="E12361C0CE16BECD" modified="2013-03-06" version="1">MTTQQLENSVQDKNSPEYWDEVPNPAEMSFFDHLEELRQRIFVSLIAVLLSAIACFAFVKTIVAWLEVPAQGVKFLQLAPGEFFFVSIQVAGYTGIILAAPVILYQIVQFVLPGLTRKERRFLAPVVFGSSILFFAGLAFAYYVLIPAALKFFIGYGGDVVEQLWSIDKYFKFILLLMFSTGLAFQIPVIQLLLGMLGIVSSQQMLSGWRIVILASLILGAVITPSTDPLTQSLLGGAVLMLYFGGIGMVKLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8U9</accession>
    <name>K9Z8U9_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220866.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3091"/>
    <dbReference type="EnsemblBacteria" id="AFZ55147">
        <property type="protein sequence ID" value="AFZ55147"/>
        <property type="gene ID" value="Cyan10605_3091"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3091"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130309_0_0_3"/>
    <dbReference type="OMA" id="SIVINYH"/>
    <dbReference type="OrthoDB" id="1849170at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="176" mass="19751" checksum="F9C8E97C39BCC749" modified="2013-03-06" version="1">MTNATVTAENSAITTTENKEQIATFLKEHEEVEMIIPVMFGLFVTSQFQLRGAKALLVNLGVATVFRQLFKELKKSPSQDTQSSTTQNQTNVSEDEEEMSILHSVKGRIRLRIPQIKKDALFAKRLERLLNDDDNVLNVRMNRTVSSVVIKYDAGNLSDMDLGFKLMSIIDAAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z900</accession>
    <name>K9Z900_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220799.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3021"/>
    <dbReference type="EnsemblBacteria" id="AFZ55080">
        <property type="protein sequence ID" value="AFZ55080"/>
        <property type="gene ID" value="Cyan10605_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3021"/>
    <dbReference type="eggNOG" id="ENOG5032S9F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171014_0_0_3"/>
    <dbReference type="OMA" id="TFFNYQQ"/>
    <dbReference type="OrthoDB" id="1815435at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="111" mass="13302" checksum="6144E51EC058E130" modified="2013-03-06" version="1">MTYCFDIVGIAPVLDFFYYQQKVEQSPHRSKAYLGSYECTLDSFIQSTEMILQKPDWNWDQVIESIIDFWLHQEKEIEKWRSSFTKTKEEILIIGRIANVNLLRRDFDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z914</accession>
    <name>K9Z914_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ordered locus">Cyan10605_3146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220915.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3146"/>
    <dbReference type="EnsemblBacteria" id="AFZ55197">
        <property type="protein sequence ID" value="AFZ55197"/>
        <property type="gene ID" value="Cyan10605_3146"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3146"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3353"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_3"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="144"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="540"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="597" mass="67934" checksum="7E6D201E11F984F7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9B5</accession>
    <name>K9Z9B5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221035.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3271"/>
    <dbReference type="EnsemblBacteria" id="AFZ55317">
        <property type="protein sequence ID" value="AFZ55317"/>
        <property type="gene ID" value="Cyan10605_3271"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3271"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102563_0_0_3"/>
    <dbReference type="OMA" id="IGCNGGF"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027555">
        <property type="entry name" value="Mo5U34_MeTrfas-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08003">
        <property type="entry name" value="Methyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="244" mass="28408" checksum="F2E3BE4AEA7DC718" modified="2013-03-06" version="1">MNQSKEIDKENLVKEVAKIKYWHHYIDFGAGVETKTGKEGRFCKKFQNWILSGIPQDLTGKTVLDIGAWDGFYSFSAEKRGAKRVLATDSFIWEQRQLYGLDDNFWRDFGAGKQGFELARKMFNSQVEDYNIDVLDFNPEKIGTFDVVFFLGVLYHMKYPLYALEKVRSVTKELLILETHISLFFSLFPVPLMRFYPTNELSKDVTNWTGANIALVKSWLLTAGFSKVELVKWRKDRAIFHAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9C7</accession>
    <name>K9Z9C7_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Cyan10605_3286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221050.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3286"/>
    <dbReference type="EnsemblBacteria" id="AFZ55332">
        <property type="protein sequence ID" value="AFZ55332"/>
        <property type="gene ID" value="Cyan10605_3286"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3286"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3501"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_3"/>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="338" mass="35783" checksum="75ED1832E280BA32" modified="2013-03-06" version="1" precursor="true">MRVSLKSTNSSIPLIILLIVVTVILCLSFLASLTFGVADIHWQDLPKAFTAFDGSTSHLIITTIRLPRAIIALLVGAGLGMAGSLMQGITRNPLADPSILGINSGAVLAVVVTTFVLNEPSLNILAIFAFLGATISSIAVYFFASLSKNGLSPLSLTLAGSAITVFCSSLTSGILILNQRTLDEIRFWLAGSIAGRDIELIKQILPYFVIGLILALILARQITILSLGEETAKGLGQNTLLIKIGAMIAVILLAGASVSLAGPIGFIGLIMPHLVRLLVGNDYRWILPFSMLGGAILLLNADIVSRLILKPQEVPVGLILPILGAPFFIYLIQGKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9M5</accession>
    <name>K9Z9M5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_3234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220998.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3234"/>
    <dbReference type="EnsemblBacteria" id="AFZ55280">
        <property type="protein sequence ID" value="AFZ55280"/>
        <property type="gene ID" value="Cyan10605_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3234"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3448"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_3"/>
    <dbReference type="OMA" id="HDHVILT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ55280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="169" mass="19693" checksum="C974C3B49109C45B" modified="2013-03-06" version="1">MSPDITASIKKKLNSRGWRMTPQREKILEVFQNLPQGNHLSAEELHQMLTESGENISLSTIYRSVKLMTKMRVLRELELAEGHKHYELNHPYPHHHHHIVCIQCNKTIEFQDDSILKHSLKQCQKEEFQLIDCQLTVMTICKEAIEMGWPSTLPTDWCCSRAIAEGHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9R1</accession>
    <name>K9Z9R1_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name evidence="2" type="ordered locus">Cyan10605_3274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3274"/>
    <dbReference type="EnsemblBacteria" id="AFZ55320">
        <property type="protein sequence ID" value="AFZ55320"/>
        <property type="gene ID" value="Cyan10605_3274"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3274"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3489"/>
    <dbReference type="eggNOG" id="COG0603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_1_3"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="217" mass="23176" checksum="7595005651ED1CAB" modified="2013-03-06" version="1" precursor="true">MKKAIVLLSGGLDSATSAAIAVSQGYDTIALSFRYGQKHAKELEIAQNLAPKLGIKEHFVIDVNLSLWGGSSLTDNNLAIPQEGVNPQIIPSTYVPGRNTVFIAIALSLAEAASAEAIYLGINAVDYSGYPDCRPEYLQAFQNLANLSSKVGIEGKTPQLIAPLINLSKVDIIKKALSLNVPIDETWSCYQGGEIPCGVCDSCRIRNEALKQLGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9W3</accession>
    <name>K9Z9W3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(P)H dehydrogenase, subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NADH-plastoquinone oxidoreductase subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
            <shortName evidence="5">NDH-H</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndhH</name>
        <name evidence="8" type="ordered locus">Cyan10605_3331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cellular thylakoid membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221093.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3331"/>
    <dbReference type="EnsemblBacteria" id="AFZ55375">
        <property type="protein sequence ID" value="AFZ55375"/>
        <property type="gene ID" value="Cyan10605_3331"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3331"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3546"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_3"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031676">
        <property type="term" value="C:plasma membrane-derived thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="124"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ55375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="394" mass="45518" checksum="88F2BE1FB4FE48BF" modified="2013-03-06" version="1">MAKIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVIDCEPVIGYLHRGMEKIAENRTNVMFVPYVSRWDYAAGMFNEAITVNAPEKLADIEVPKRAQYIRVIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGMRLINNNYFRIGGVAVDLPYGWVDKCEDFCDYFLPKVDEYEKLITNNPIFRKRVEGVGVITREQAINWSLSGPMLRGSGVKWDLRKVDRYECYDDFDWDVQWETAGDCFARYIVRIREMRESVKIIRQALKGLPGGPYENLEAKRLQEGKKSKWNDFEYQYIAKKVPPTFKIPAGEHYVRMESGKGELGVFIVGNDDVFPWRFKIRAPDFNNLQILPELLRGVKVADIMAILGSIDVIMGSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAB5</accession>
    <name>K9ZAB5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_3502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pCYAN10605.01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
            <plasmid evidence="2">Plasmid pCYAN10605.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003948">
        <property type="protein sequence ID" value="AFZ55535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3502"/>
    <dbReference type="EnsemblBacteria" id="AFZ55535">
        <property type="protein sequence ID" value="AFZ55535"/>
        <property type="gene ID" value="Cyan10605_3502"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3502"/>
    <dbReference type="HOGENOM" id="CLU_2179471_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Plasmid pCYAN10605.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ55535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="109" mass="12814" checksum="6DB1E30A90B884FE" modified="2013-03-06" version="1">MEVPTVNDYTSALRKIEMTELQTELLRIQYSAPHHQIKLEDLAIAVSKPIETINAVYGNLAHKIKDLLAVEIIGEGYWKVLSIGYEQDNRYYWQMRNQVVYALRELNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9ZAD3</accession>
    <name>K9ZAD3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-chelate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_3287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015221051.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3287"/>
    <dbReference type="EnsemblBacteria" id="AFZ55333">
        <property type="protein sequence ID" value="AFZ55333"/>
        <property type="gene ID" value="Cyan10605_3287"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3287"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3502"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_3"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ55333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="270" mass="30093" checksum="2E41EC96E11910D5" modified="2013-03-06" version="1">MKQISARKLSLGYQNIDIINNLNLDIPQGKITILIGANGCGKSTLLKGIGRILKPRQGAVYLDGKAIHQQKSVTVAQSLGILPQNPTAPEGLTVKDLVIQGRYPHQKWWQQWTLEDEAQVNKALAMTGIQEFSHRELDTLSGGQRQRAWIAMTLAQNTEILLLDEPTTFLDLAHQIEVLDLLKELNHKLERTIIIVLHELNQAARYADYLVAMKEGYIYAKGKPEEVMTSEIIKEVFGLESHIISDPITNTPLCIPISGYLPTQINLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0A2</accession>
    <name>K9Z0A2_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_0452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0452"/>
    <dbReference type="EnsemblBacteria" id="AFZ52594">
        <property type="protein sequence ID" value="AFZ52594"/>
        <property type="gene ID" value="Cyan10605_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0452"/>
    <dbReference type="HOGENOM" id="CLU_1608127_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ52594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="165" mass="19898" checksum="1B3D57E7288B5AD9" modified="2013-03-06" version="1">MLESYMKQITNCINSLSSYLRENQEEKRQNYCEKLEQALELVIKFFKKYDTLNNHSFRCQNIDIDLLMNPEREVRLEINTQNKTEDFKKSMTTKELVNYCWDNKMDVKSLITNLFSYINQILSKKKQRMSNEIDRYNSEINCLNEAIDNLNELIEMDIPEEIKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z0F3</accession>
    <name>K9Z0F3_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_0026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0026"/>
    <dbReference type="EnsemblBacteria" id="AFZ52187">
        <property type="protein sequence ID" value="AFZ52187"/>
        <property type="gene ID" value="Cyan10605_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0026"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.28"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_2_3"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="OrthoDB" id="1744995at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ52187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="265" mass="27909" checksum="73AC8832AB226ACF" modified="2013-03-06" version="1">MATISVINNYLELDVMKKYIAEFFGTFWLVLGGCGSAVLAANFGGEGNPLELGFLGVSLGFGLTVLTMAYAVGHISGGHFNPAVSFDLFAGKRFSGSDLLPYIIAQVLGAILAGAVLFIIASGNGALDLSGSNPLATNGYGSHSPGGYNLFAPLITEIIMTFMFLVIIMGATDRLALGGFGPSAIGLALTLIHLISIPVTNTSVNPARSTGVALFCGNMEIIAQLWLFWFAPIVGAVLGGWFYYQFLETGIESRPLQPIESEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z201</accession>
    <name>K9Z201_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Cyan10605_0478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218351.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0478"/>
    <dbReference type="EnsemblBacteria" id="AFZ52620">
        <property type="protein sequence ID" value="AFZ52620"/>
        <property type="gene ID" value="Cyan10605_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0478"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.506"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_3"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ52620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="359" mass="39769" checksum="572F6EB8B12627CF" modified="2013-03-06" version="1">MAQLKLENLKKQFAPNVIPVKDISLTVNDGDFITLLGPSGCGKSTLLRLIAGLEKPTNGKVILDEKELNNIPPGDRNMAMVFQSYALYPHMSVFDNIASALKIRKIPPEEIKNRVSVVSSNLGLTDLLNRKPKQLSGGQRQRVALARALVRKPDVFLLDEPLSNLDALLREKVRAELKQLFANQNKPVIYVTHDQTEAMTLSSKVVVLLDGLIQQIDTPDRIYNQPANKFVAGFVGSPQMNLLNLECKQGSALLGETIIPLPKGNESLSEVDLGIRPEDITLATENHKITVTGKVLLTENFGRELLVSVEIPNSNHFLRILINPELQWNENNIKLALNPNKLHWFCTNTGNSILSGINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z298</accession>
    <name>K9Z298_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Cyan10605_0722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">PCC 10605</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218588.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0722"/>
    <dbReference type="EnsemblBacteria" id="AFZ52857">
        <property type="protein sequence ID" value="AFZ52857"/>
        <property type="gene ID" value="Cyan10605_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0722"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.757"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_3_3"/>
    <dbReference type="OMA" id="EWTRGAY"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003938641" evidence="3">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="469" mass="52826" checksum="1B56F4E61C163F89" modified="2013-03-06" version="1" precursor="true">MINRRFFLIVSSVILAHVVASKNFASNSLKTTKKNKEKIIIIGAGIAGLTAGKTLQNQGFEVILLEARNRIGGRLWTSKKWDNAFVDMGASWIHGEEGNPITKLANTINAQVFSTKSEKSIIYDLNGKEIIEDKEEKLDKLTNKLKEIINKIQNNYYYDISLQKALEKELKWQTLSDVNKQYLEYLLNSNIEQEYAADISQLSAFYFDEGKAFDGDDSLFIKGYNVISDYLAQGLNIKLNHTVEAIGVAAPSVNASNSQGVNVITNKSNFQADRVIVTLPLGVLQKNIVKFSPALPEKKLEAINQLGMGVLNKLYVLFPKRFWQNNYDWIGKISEKKGQWSEWVNLESALKKPILLGFNAGKFGKEIESWSDEEIIADAMKTLRQIYGNSIPQPIDYQLTRWSQDPFTFGSYSYYATNSTPNHRQELAKPINKKVFFAGEATSIDYPATVHGAYFSGLRVSQEIIALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z373</accession>
    <name>K9Z373_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_1493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219333.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1493"/>
    <dbReference type="EnsemblBacteria" id="AFZ53604">
        <property type="protein sequence ID" value="AFZ53604"/>
        <property type="gene ID" value="Cyan10605_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1493"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042265_0_0_3"/>
    <dbReference type="OMA" id="IEDWLQN"/>
    <dbReference type="OrthoDB" id="454779at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ53604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="540" mass="63642" checksum="1CD8ADAE3D58ECBB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z393</accession>
    <name>K9Z393_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-mercaptopyruvate sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015218791.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_0930"/>
    <dbReference type="EnsemblBacteria" id="AFZ53060">
        <property type="protein sequence ID" value="AFZ53060"/>
        <property type="gene ID" value="Cyan10605_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_0930"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.978"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_3"/>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="OrthoDB" id="920668at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="168"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="277" mass="31897" checksum="46BB485130FE37A8" modified="2013-03-06" version="1">MGSTQVTVSAQWLKDNLGRSDLKIIDCRFRLADSQWGYQEYQKSHIENAYYLDLNQDLSDVVQSHGGRHPLPKIDAFTSKLEEFGIIKGETTVIAYDDLRLAFSARLWWLLRYLGHDRIFILDGGWQEWQKLGYPVSNKIPDRVRGSFLPEIRSDLLVDKDYVESRLNFDSTIIIDARSGDRYRGEHEPIDPIAGSIPGAKNIFWQEMTTDDSFLKSEEELTSLWSSYLEYPEIILYCGSGVTACVNLLALFKINISQSKLYAGGWSDWCSYPEHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z415</accession>
    <name>K9Z415_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Cyan10605_1834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219663.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1834"/>
    <dbReference type="EnsemblBacteria" id="AFZ53936">
        <property type="protein sequence ID" value="AFZ53936"/>
        <property type="gene ID" value="Cyan10605_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1834"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1946"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_3"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="562" mass="64993" checksum="11577203637C5351" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z461</accession>
    <name>K9Z461_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ53163">
        <property type="protein sequence ID" value="AFZ53163"/>
        <property type="gene ID" value="Cyan10605_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1037"/>
    <dbReference type="HOGENOM" id="CLU_217153_0_0_3"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ53163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="31" mass="3549" checksum="73D5C5F2FE26F31E" modified="2013-03-06" version="1">MDDGTKYAIFLVISCLLIIGLLWLPDILRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z518</accession>
    <name>K9Z518_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ordered locus">Cyan10605_1396</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015219237.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_1396"/>
    <dbReference type="EnsemblBacteria" id="AFZ53508">
        <property type="protein sequence ID" value="AFZ53508"/>
        <property type="gene ID" value="Cyan10605_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_1396"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.1474"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_1_1_3"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5013998641" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013998640" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="138" mass="15546" checksum="E8F80D1E63131FF2" modified="2013-03-06" version="1">MTTIRLMHAKLHRVRVTSANVDYVGSISIDPDLMEKVGILPLEELDIVNLNNAKRWSTYAIPGERGSKEICPNGGAALLCQEGDILIIYAYEECDRGELIKKGHKAKVLVADENNNIADFFEQTLTPNQDKFHFQERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z678</accession>
    <name>K9Z678_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Cyan10605_2146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2146"/>
    <dbReference type="EnsemblBacteria" id="AFZ54232">
        <property type="protein sequence ID" value="AFZ54232"/>
        <property type="gene ID" value="Cyan10605_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2146"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2280"/>
    <dbReference type="eggNOG" id="ENOG5032RTM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144856_0_0_3"/>
    <dbReference type="OMA" id="GTYGHFP"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014953">
        <property type="entry name" value="DUF1824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08854">
        <property type="entry name" value="DUF1824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ54232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="135" mass="15519" checksum="24770088F68AD41E" modified="2013-03-06" version="1">MMNEKIKQALSLLKSYSCLQLKTIKSEQEKQELESSIKLIVSLSDNQNFGICASNSHEAFNTLKNYLKALGYEENIDTEKVTENKPVYLKFNTEKKSYHLSDYSGDYRGVLITIFADFNEEIIGTYGHFPLNLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7E3</accession>
    <name>K9Z7E3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Cyan10605_2579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220380.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2579"/>
    <dbReference type="EnsemblBacteria" id="AFZ54657">
        <property type="protein sequence ID" value="AFZ54657"/>
        <property type="gene ID" value="Cyan10605_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2579"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2740"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_0_3"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ54657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="168" mass="18339" checksum="270DC13C2BA6CE71" modified="2013-03-06" version="1">MPIDFNQLREFIEAIAKTDISELAIKEGDFELTLQKNSPYSNNAVYSIATPVSPPQSITPVQENNHAVEVDTPSTPPAEKSSASKKTDNWLAITSPMVGTFYRAPAPGEPPFVENGDRISDGQVVCIIEAMKLMNEIEAEVSGQIMEIAVENGEPVEYGQTLMWVAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7H5</accession>
    <name>K9Z7H5_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ordered locus">Cyan10605_2253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ54338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220062.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2253"/>
    <dbReference type="EnsemblBacteria" id="AFZ54338">
        <property type="protein sequence ID" value="AFZ54338"/>
        <property type="gene ID" value="Cyan10605_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2253"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.2394"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_1_0_3"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ54338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="198" mass="21857" checksum="B5F826602ACFEA7A" modified="2013-03-06" version="1">MLSVNDFSKAIRATLILWLITAIIYPLFILIFGQIFLPYQANGSLIKDNQNNIIGSSLIGQSFQSDRYFWSRPSVINYSTGEDGGETGVSGASNLAPSNPDLVKNIEAEITKLKQVGITPTADLVYTSGSGLDPHISIQSAQNQIERIAIARNLDPNQLRELIKSHTEGRFLGIFGEPRINTLKLNIELDEFSKEIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z7S7</accession>
    <name>K9Z7S7_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ordered locus">Cyan10605_3187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015220954.1">
        <property type="nucleotide sequence ID" value="NC_019776.1"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3187"/>
    <dbReference type="EnsemblBacteria" id="AFZ55236">
        <property type="protein sequence ID" value="AFZ55236"/>
        <property type="gene ID" value="Cyan10605_3187"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3187"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3397"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_3"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ55236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="330" mass="36104" checksum="05D1C83D31E171C8" modified="2013-03-06" version="1">MAQMYYDNDAKLELISSKTVAIIGYGSQGHAHALNLKESGVNVIVGLYEGSKSKAKAESAGLKVHSVAEAASLADWIMILLPDEVQRTVYEQEIAPYLTKGKVLSFAHGFNIHFGQIVPPADVDVVMIAPKGPGHLVRRTYEQGQGVPALFAVYQDASGEARDRAMAYAKGIGGTRAGILETSFREETETDLFGEQAVLCGGLSALIKAGFETLVSAGYQPELAYFECLHEVKLIVDLIVEGGLAEMRNSISNTAEYGDYTRGPRVITDETRAEMKKILTEIQSGQFAREFILENQAGKPGFTAMRRRESEETIEEVGKDLRAMFSWLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z8G3</accession>
    <name>K9Z8G3_CYAAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ordered locus">Cyan10605_2955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">PCC 10605</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_2955"/>
    <dbReference type="EnsemblBacteria" id="AFZ55017">
        <property type="protein sequence ID" value="AFZ55017"/>
        <property type="gene ID" value="Cyan10605_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_2955"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3144"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_3"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ55017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="410" mass="43738" checksum="7AA3CDE870C77879" modified="2013-03-06" version="1">MQGEVKISGAKNSALAIMAGTLLCEDECRLNNMPCLVDVNTMGQVLSSLGVKIEKKGTTWDFDCRDIKAVKAPYDLVSQLRASFFVIGPILTRLGVAQVPLPGGCAIGSRPVDLHVRGLQAMGAHVTIEHGVVNASVKGGRLKGTKIFLDYPSVGATETIIMAATLAEGETIIENAAKEPEIVDLANFCNSMGAKIRGAGTDSIVIEGVDRLHTTDYHIIPDRIEAGTFLVAGAITHSEILVTSVNPEHLIPVISKLEEIGCQIKQESATVLRTIPGELKASDIETLPHPGFPTDMQAQFMALLTISEGNSLVTETVFENRLRHVAELQRMGANIKVKGNSALVSGVSRLSGAPVMATDLRASAALVLAGLAADGKTIVQGLQHLDRGYENLEQKFQNLGASIRRISYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K9Z9U5</accession>
    <name>K9Z9U5_CYAAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Cyan10605_3455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cyanobacterium aponinum (strain PCC 10605)</name>
        <dbReference type="NCBI Taxonomy" id="755178"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Cyanobacteria</taxon>
            <taxon>Oscillatoriophycideae</taxon>
            <taxon>Chroococcales</taxon>
            <taxon>Geminocystaceae</taxon>
            <taxon>Cyanobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="1053" last="1058">
            <title>Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.</title>
            <authorList>
                <person name="Shih P.M."/>
                <person name="Wu D."/>
                <person name="Latifi A."/>
                <person name="Axen S.D."/>
                <person name="Fewer D.P."/>
                <person name="Talla E."/>
                <person name="Calteau A."/>
                <person name="Cai F."/>
                <person name="Tandeau de Marsac N."/>
                <person name="Rippka R."/>
                <person name="Herdman M."/>
                <person name="Sivonen K."/>
                <person name="Coursin T."/>
                <person name="Laurent T."/>
                <person name="Goodwin L."/>
                <person name="Nolan M."/>
                <person name="Davenport K.W."/>
                <person name="Han C.S."/>
                <person name="Rubin E.M."/>
                <person name="Eisen J.A."/>
                <person name="Woyke T."/>
                <person name="Gugger M."/>
                <person name="Kerfeld C.A."/>
            </authorList>
            <dbReference type="PubMed" id="23277585"/>
            <dbReference type="DOI" id="10.1073/pnas.1217107110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">PCC 10605</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003947">
        <property type="protein sequence ID" value="AFZ55492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="755178.Cyan10605_3455"/>
    <dbReference type="EnsemblBacteria" id="AFZ55492">
        <property type="protein sequence ID" value="AFZ55492"/>
        <property type="gene ID" value="Cyan10605_3455"/>
    </dbReference>
    <dbReference type="KEGG" id="can:Cyan10605_3455"/>
    <dbReference type="PATRIC" id="fig|755178.3.peg.3679"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_3"/>
    <dbReference type="OMA" id="DVNFPET"/>
    <dbReference type="Proteomes" id="UP000010480">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ55492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010480"/>
        </source>
    </evidence>
    <sequence length="326" mass="36606" checksum="603FBFB945F2D019" modified="2013-03-06" version="1">MEFKDYYSVLGVDKKASGEEIKKAFRKLAVKYHPDRNPDNKAAEEKFKEISEAYEVLGDTEKRKKYDQFIRYGRPMGQRTTSRNTTTWGNTYQTRSSNDMDFDFGKYNSFDEFIADLLGRPFGNTRTQTTGFSDFGGFNTGTTASQGRGNDIEKSITLTYYQAYHGVQTKLDLGSEIVTVKIPAGAKNGTKVRLKGKGQINPISNHKGDLYLKVELKPHDFFSFEDDKLVCEVPITPYEAVLGGEVNVPTPEGEVMVKIPAGIRHGQSLRLKGKGWSNPKGGNGDLLVKIAIATPKNISDQEKEYYEKIRSISQDDPRLSLKNIKL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>